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Nathan Gianneschi

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0343
La Jolla CA 92093
Phone858-246-0857
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    Collapse Research 
    Collapse Research Activities and Funding
    MMP Responsive Nanoparticles for Treating Acute Myocardial Infarction
    NIH/NHLBI R01HL139001Sep 1, 2017 - Aug 31, 2021
    Role: Co-Principal Investigator
    Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
    NIH/NHLBI R01HL117326Sep 20, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Programming Pharmacokinetics in Vivo via In Situ Switching of Nanoscale Particle
    NIH DP2OD008724Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim YK, Huang Y, Tsuei M, Wang X, Gianneschi N, Abbott NL. Multi-Scale Responses of Liquid Crystals Triggered by Interfacial Assemblies of Cleavable Homopolymers. Chemphyschem. 2018 Apr 22. PMID: 29682873.
      View in: PubMed
    2. Smith WJ, Tran H, Griffin JI, Jones J, Vu VP, Nilewski L, Gianneschi N, Simberg D. Lipophilic indocarbocyanine conjugates for efficient incorporation of enzymes, antibodies and small molecules into biological membranes. Biomaterials. 2018 Apr; 161:57-68. PMID: 29421563.
      View in: PubMed
    3. Denny MS, Parent LR, Patterson JP, Meena SK, Pham H, Abellan P, Ramasse QM, Paesani F, Gianneschi N, Cohen SM. Transmission Electron Microscopy Reveals Deposition of Metal Oxide Coatings onto Metal-Organic Frameworks. J Am Chem Soc. 2018 Jan 31; 140(4):1348-1357. PMID: 29268603.
      View in: PubMed
    4. Roloff A, Nelles DA, Thompson MP, Yeo GW, Gianneschi N. Self-Transfecting Micellar RNA: Modulating Nanoparticle Cell Interactions via High Density Display of Small Molecule Ligands on Micelle Coronas. Bioconjug Chem. 2018 Jan 17; 29(1):126-135. PMID: 29286237.
      View in: PubMed
    5. Homyak CC, Fernandez A, Touve MA, Zhao B, Anson F, Hardy JA, Vachet RW, Gianneschi N, Ross JL, Thayumanavan S. Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules. Biomacromolecules. 2018 Jan 08; 19(1):132-140. PMID: 29141403.
      View in: PubMed
    6. Parent LR, Bakalis E, Proetto M, Li Y, Park C, Zerbetto F, Gianneschi N. Tackling the Challenges of Dynamic Experiments Using Liquid-Cell Transmission Electron Microscopy. Acc Chem Res. 2018 Jan 16; 51(1):3-11. PMID: 29227618.
      View in: PubMed
    7. Parent LR, Bakalis E, Ramírez-Hernández A, Kammeyer JK, Park C, de Pablo J, Zerbetto F, Patterson JP, Gianneschi N. Directly Observing Micelle Fusion and Growth in Solution by Liquid-Cell Transmission Electron Microscopy. J Am Chem Soc. 2017 Nov 29; 139(47):17140-17151. PMID: 29145727.
      View in: PubMed
    8. Roloff A, Carlini AS, Callmann CE, Gianneschi N. Micellar Thrombin-Binding Aptamers: Reversible Nanoscale Anticoagulants. J Am Chem Soc. 2017 11 22; 139(46):16442-16445. PMID: 29135251.
      View in: PubMed
    9. Zheng Z, Zhang H, Nam JM, Gianneschi N. Frontiers in Nanointerfaces Research. Small. 2017 Nov; 13(43). PMID: 29136355.
      View in: PubMed
    10. Wang Z, Carniato F, Xie Y, Huang Y, Li Y, He S, Zang N, Rinehart JD, Botta M, Gianneschi N. High Relaxivity Gadolinium-Polydopamine Nanoparticles. Small. 2017 Nov; 13(43). PMID: 29024478.
      View in: PubMed
    11. Adamiak L, Touve MA, LeGuyader CLM, Gianneschi N. Peptide Brush Polymers and Nanoparticles with Enzyme-Regulated Structure and Charge for Inducing or Evading Macrophage Cell Uptake. ACS Nano. 2017 Oct 24; 11(10):9877-9888. PMID: 28972735.
      View in: PubMed
    12. Parent LR, Pham CH, Patterson JP, Denny MS, Cohen SM, Gianneschi N, Paesani F. Pore Breathing of Metal-Organic Frameworks by Environmental Transmission Electron Microscopy. J Am Chem Soc. 2017 Oct 11; 139(40):13973-13976. PMID: 28942647.
      View in: PubMed
    13. Xiao M, Hu Z, Wang Z, Li Y, Tormo AD, Le Thomas N, Wang B, Gianneschi N, Shawkey MD, Dhinojwala A. Bioinspired bright noniridescent photonic melanin supraballs. Sci Adv. 2017 Sep; 3(9):e1701151. PMID: 28929137.
      View in: PubMed
    14. Huang Y, Li Y, Hu Z, Yue X, Proetto MT, Jones Y, Gianneschi N. Mimicking Melanosomes: Polydopamine Nanoparticles as Artificial Microparasols. ACS Cent Sci. 2017 Jun 28; 3(6):564-569. PMID: 28691067.
      View in: PubMed
    15. Leriche G, Cifelli JL, Sibucao KC, Patterson JP, Koyanagi T, Gianneschi N, Yang J. Characterization of drug encapsulation and retention in archaea-inspired tetraether liposomes. Org Biomol Chem. 2017 Mar 08; 15(10):2157-2162. PMID: 28221378.
      View in: PubMed
    16. Smith BJ, Parent LR, Overholts AC, Beaucage PA, Bisbey RP, Chavez AD, Hwang N, Park C, Evans AM, Gianneschi N, Dichtel WR. Colloidal Covalent Organic Frameworks. ACS Cent Sci. 2017 Jan 25; 3(1):58-65. PMID: 28149954.
      View in: PubMed
    17. Callmann CE, Gianneschi N. Enzyme-Responsive Nanoparticles for the Treatment of Disease. Methods Mol Biol. 2017; 1570:223-238. PMID: 28238140.
      View in: PubMed
    18. Huang Y, Vezeridis AM, Wang J, Wang Z, Thompson M, Mattrey RF, Gianneschi N. Polymer-Stabilized Perfluorobutane Nanodroplets for Ultrasound Imaging Agents. J Am Chem Soc. 2017 01 11; 139(1):15-18. PMID: 28032757.
      View in: PubMed
    19. Li Y, Xie Y, Wang Z, Zang N, Carniato F, Huang Y, Andolina CM, Parent LR, Ditri TB, Walter ED, Botta M, Rinehart JD, Gianneschi N. Structure and Function of Iron-Loaded Synthetic Melanin. ACS Nano. 2016 Nov 22; 10(11):10186-10194. PMID: 27802021.
      View in: PubMed
    20. Johnson ME, Shon J, Guan BM, Patterson JP, Oldenhuis NJ, Eldredge AC, Gianneschi N, Guan Z. Fluorocarbon Modified Low-Molecular-Weight Polyethylenimine for siRNA Delivery. Bioconjug Chem. 2016 08 17; 27(8):1784-8. PMID: 27457882.
      View in: PubMed
    21. Carlini AS, Adamiak L, Gianneschi N. Biosynthetic Polymers as Functional Materials. Macromolecules. 2016 Jun 28; 49(12):4379-4394. PMID: 27375299.
      View in: PubMed
    22. Patterson JP, Parent LR, Cantlon J, Eickhoff H, Bared G, Evans JE, Gianneschi N. Picoliter Drop-On-Demand Dispensing for Multiplex Liquid Cell Transmission Electron Microscopy. Microsc Microanal. 2016 Jun; 22(3):507-14. PMID: 27135268.
      View in: PubMed
    23. Proetto MT, Anderton CR, Hu D, Szymanski CJ, Zhu Z, Patterson JP, Kammeyer JK, Nilewski LG, Rush AM, Bell NC, Evans JE, Orr G, Howell SB, Gianneschi N. Cellular Delivery of Nanoparticles Revealed with Combined Optical and Isotopic Nanoscopy. ACS Nano. 2016 04 26; 10(4):4046-54. PMID: 27022832.
      View in: PubMed
    24. Daniel KB, Callmann CE, Gianneschi N, Cohen SM. Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species. Chem Commun (Camb). 2016 Feb 04; 52(10):2126-8. PMID: 26696280; PMCID: PMC4729588 [Available on 01/26/17].
    25. Wright DB, Patterson JP, Gianneschi N, Chassenieux C, Colombani O, O'Reilly RK. Blending block copolymer micelles in solution; Obstacles of blending. Polym Chem. 2016 Feb 28; 7(8):1577-1583. PMID: 26918033.
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    26. Patterson JP, Collins DB, Michaud JM, Axson JL, Sultana CM, Moser T, Dommer AC, Conner J, Grassian VH, Stokes MD, Deane GB, Evans JE, Burkart MD, Prather KA, Gianneschi N. Sea Spray Aerosol Structure and Composition Using Cryogenic Transmission Electron Microscopy. ACS Cent Sci. 2016 Jan 27; 2(1):40-47. PMID: 26878061.
      View in: PubMed
    27. Li Y, Huang Y, Wang Z, Carniato F, Xie Y, Patterson JP, Thompson MP, Andolina CM, Ditri TB, Millstone JE, Figueroa JS, Rinehart JD, Scadeng M, Botta M, Gianneschi N. Polycatechol Nanoparticle MRI Contrast Agents. Small. 2016 Feb 03; 12(5):668-77. PMID: 26681255.
      View in: PubMed
    28. Wang Z, Li Y, Huang Y, Thompson MP, LeGuyader CL, Sahu S, Gianneschi N. Enzyme-regulated topology of a cyclic peptide brush polymer for tuning assembly. Chem Commun (Camb). 2015 Dec 14; 51(96):17108-11. PMID: 26452255.
      View in: PubMed
    29. Blum AP, Kammeyer JK, Gianneschi N. Activating Peptides for Cellular Uptake via Polymerization into High Density Brushes. Chem Sci. 2016 Feb 01; 7(2):989-994. PMID: 26925209.
      View in: PubMed
    30. Veccharelli KM, Tong VK, Young JL, Yang J, Gianneschi N. Dual responsive polymeric nanoparticles prepared by direct functionalization of polylactic acid-based polymers via graft-from ring opening metathesis polymerization. Chem Commun (Camb). 2016 Jan 11; 52(3):567-70. PMID: 26541981.
      View in: PubMed
    31. Ma CD, Adamiak L, Miller DS, Wang X, Gianneschi N, Abbott NL. Liquid Crystal Interfaces Programmed with Enzyme-Responsive Polymers and Surfactants. Small. 2015 Nov 18; 11(43):5747-51. PMID: 26418129.
      View in: PubMed
    32. Nguyen MM, Carlini AS, Chien MP, Sonnenberg S, Luo C, Braden RL, Osborn KG, Li Y, Gianneschi N, Christman KL. Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction. Adv Mater. 2015 Oct 07; 27(37):5547-52. PMID: 26305446; PMCID: PMC4699559 [Available on 10/01/16].
    33. Bell NC, Doyle SJ, Battistelli G, LeGuyader CL, Thompson MP, Poe AM, Rheingold A, Moore C, Montalti M, Thayumanavan S, Tauber MJ, Gianneschi N. Dye Encapsulation in Polynorbornene Micelles. Langmuir. 2015 Sep 08; 31(35):9707-17. PMID: 26305151; PMCID: PMC4921242.
    34. Callmann CE, Barback CV, Thompson MP, Hall DJ, Mattrey RF, Gianneschi N. Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors. Adv Mater. 2015 Aug 19; 27(31):4611-5. PMID: 26178920; PMCID: PMC4699560.
    35. Patterson JP, Abellan P, Denny MS, Park C, Browning ND, Cohen SM, Evans JE, Gianneschi N. Observing the growth of metal-organic frameworks by in situ liquid cell transmission electron microscopy. J Am Chem Soc. 2015 Jun 17; 137(23):7322-8. PMID: 26053504.
      View in: PubMed
    36. Xiao M, Li Y, Allen MC, Deheyn DD, Yue X, Zhao J, Gianneschi N, Shawkey MD, Dhinojwala A. Bio-Inspired Structural Colors Produced via Self-Assembly of Synthetic Melanin Nanoparticles. ACS Nano. 2015 May 26; 9(5):5454-60. PMID: 25938924.
      View in: PubMed
    37. Nguyen MM, Gianneschi N, Christman KL. Developing injectable nanomaterials to repair the heart. Curr Opin Biotechnol. 2015 Aug; 34:225-31. PMID: 25863496; PMCID: PMC4555187.
    38. Blum AP, Kammeyer JK, Rush AM, Callmann CE, Hahn ME, Gianneschi N. Stimuli-responsive nanomaterials for biomedical applications. J Am Chem Soc. 2015 Feb 18; 137(6):2140-54. PMID: 25474531; PMCID: PMC4353031.
    39. Ku TH, Sahu S, Kosa NM, Pham KM, Burkart MD, Gianneschi N. Tapping a bacterial enzymatic pathway for the preparation and manipulation of synthetic nanomaterials. J Am Chem Soc. 2014 Dec 17; 136(50):17378-81. PMID: 25468257.
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    40. Blum AP, Kammeyer JK, Yin J, Crystal DT, Rush AM, Gilson MK, Gianneschi N. Peptides displayed as high density brush polymers resist proteolysis and retain bioactivity. J Am Chem Soc. 2014 Oct 29; 136(43):15422-37. PMID: 25314576; PMCID: PMC4227725.
    41. James CR, Rush AM, Insley T, Vukovic L, Adamiak L, Král P, Gianneschi N. Poly(oligonucleotide). J Am Chem Soc. 2014 Aug 13; 136(32):11216-9. PMID: 25077676; PMCID: PMC4140503.
    42. Rush AM, Nelles DA, Blum AP, Barnhill SA, Tatro ET, Yeo GW, Gianneschi N. Intracellular mRNA regulation with self-assembled locked nucleic acid polymer nanoparticles. J Am Chem Soc. 2014 May 28; 136(21):7615-8. PMID: 24827740; PMCID: PMC4046771.
    43. Thompson MP, Randolph LM, James CR, Davalos AN, Hahn ME, Gianneschi N. Labelling Polymers and Micellar Nanoparticles via Initiation, Propagation and Termination with ROMP. Polym Chem. 2014 Mar 21; 5(6):1954-1964. PMID: 24855496.
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    44. Proetto MT, Rush AM, Chien MP, Abellan Baeza P, Patterson JP, Thompson MP, Olson NH, Moore CE, Rheingold AL, Andolina C, Millstone J, Howell SB, Browning ND, Evans JE, Gianneschi N. Dynamics of soft nanomaterials captured by transmission electron microscopy in liquid water. J Am Chem Soc. 2014 Jan 29; 136(4):1162-5. PMID: 24422495; PMCID: PMC4021868.
    45. Shih YR, Hwang Y, Phadke A, Kang H, Hwang NS, Caro EJ, Nguyen S, Siu M, Theodorakis EA, Gianneschi N, Vecchio KS, Chien S, Lee OK, Varghese S. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):990-5. PMID: 24395775; PMCID: PMC3903237.
    46. Chien MP, Carlini AS, Hu D, Barback CV, Rush AM, Hall DJ, Orr G, Gianneschi N. Enzyme-directed assembly of nanoparticles in tumors monitored by in vivo whole animal imaging and ex vivo super-resolution fluorescence imaging. J Am Chem Soc. 2013 Dec 18; 135(50):18710-3. PMID: 24308273; PMCID: PMC4021865.
    47. Chien MP, Thompson MP, Barback CV, Ku TH, Hall DJ, Gianneschi N. Enzyme-directed assembly of a nanoparticle probe in tumor tissue. Adv Mater. 2013 Jul 12; 25(26):3599-604. PMID: 23712821; PMCID: PMC4108424.
    48. Hahn ME, Randolph LM, Adamiak L, Thompson MP, Gianneschi N. Polymerization of a peptide-based enzyme substrate. Chem Commun (Camb). 2013 Apr 11; 49(28):2873-5. PMID: 23450132; PMCID: PMC3608426.
    49. Rush AM, Thompson MP, Tatro ET, Gianneschi N. Nuclease-resistant DNA via high-density packing in polymeric micellar nanoparticle coronas. ACS Nano. 2013 Feb 26; 7(2):1379-87. PMID: 23379679; PMCID: PMC3608424.
    50. Kammeyer JK, Blum AP, Adamiak L, Hahn ME, Gianneschi N. Polymerization of Protecting-Group-Free Peptides via ROMP. Polym Chem. 2013; 41:3929-3933. PMID: 24015154.
      View in: PubMed
    51. Randolph LM, Chien MP, Gianneschi N. Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles. Chem Sci. 2012 May 01; 3(5). PMID: 24353895.
      View in: PubMed
    52. Chien MP, Thompson MP, Lin EC, Gianneschi N. Fluorogenic Enzyme-Responsive Micellar Nanoparticles. Chem Sci. 2012; 3(9):2690-2694. PMID: 23585924.
      View in: PubMed
    53. Kinsella JM, Jimenez RE, Karmali PP, Rush AM, Kotamraju VR, Gianneschi N, Ruoslahti E, Stupack D, Sailor MJ. X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles. Angew Chem Int Ed Engl. 2011 Dec 16; 50(51):12308-11. PMID: 22028313; PMCID: PMC3530424.
    54. Hahn ME, Gianneschi N. Enzyme-directed assembly and manipulation of organic nanomaterials. Chem Commun (Camb). 2011 Nov 21; 47(43):11814-21. PMID: 21959991; PMCID: PMC3699336.
    55. Kinsella JM, Ananda S, Andrew JS, Grondek JF, Chien MP, Scadeng M, Gianneschi N, Ruoslahti E, Sailor MJ. Enhanced magnetic resonance contrast of Fe3O4 nanoparticles trapped in a porous silicon nanoparticle host. Adv Mater. 2011 Sep 22; 23(36):H248-53. PMID: 21842475; PMCID: PMC3548421.
    56. Gianneschi N, Ginger DS, Rotello VM. Special issue dedicated to Chad Mirkin: 20 years of influential research. Small. 2011 Jul 18; 7(14):1851. PMID: 21755596.
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    57. Chien MP, Gianneschi N. A morphology-dependent bio-organic template for inorganic nanowire synthesis. Small. 2011 Jul 18; 7(14):2041-6. PMID: 21678554.
      View in: PubMed
    58. Ku TH, Chien MP, Thompson MP, Sinkovits RS, Olson NH, Baker TS, Gianneschi N. Controlling and switching the morphology of micellar nanoparticles with enzymes. J Am Chem Soc. 2011 Jun 08; 133(22):8392-5. PMID: 21462979; PMCID: PMC3756928.
    59. Chien MP, Thompson MP, Gianneschi N. DNA-nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and detection by DNAzyme probes. Chem Commun (Camb). 2011 Jan 07; 47(1):167-9. PMID: 20830351.
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    60. Rubinshtein M, James CR, Young JL, Ma YJ, Kobayashi Y, Gianneschi N, Yang J. Facile procedure for generating side chain functionalized poly(alpha-hydroxy acid) copolymers from aldehydes via a versatile Passerini-type condensation. Org Lett. 2010 Aug 06; 12(15):3560-3. PMID: 20608664.
      View in: PubMed
    61. Thompson MP, Chien MP, Ku TH, Rush AM, Gianneschi N. Smart lipids for programmable nanomaterials. Nano Lett. 2010 Jul 14; 10(7):2690-3. PMID: 20518544; PMCID: PMC2912439.
    62. Chien MP, Rush AM, Thompson MP, Gianneschi N. Programmable shape-shifting micelles. Angew Chem Int Ed Engl. 2010 Jul 12; 49(30):5076-80. PMID: 20533475; PMCID: PMC4671773.
    63. Masar MS, Gianneschi N, Oliveri CG, Stern CL, Nguyen ST, Mirkin CA. Allosterically regulated supramolecular catalysis of acyl transfer reactions for signal amplification and detection of small molecules. J Am Chem Soc. 2007 Aug 22; 129(33):10149-58. PMID: 17655295.
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    64. Gianneschi N, Ghadiri MR. Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme. Angew Chem Int Ed Engl. 2007; 46(21):3955-8. PMID: 17427900; PMCID: PMC2790070.
    65. Oliveri CG, Gianneschi N, Nguyen ST, Mirkin CA, Stern CL, Wawrzak Z, Pink M. Supramolecular allosteric cofacial porphyrin complexes. J Am Chem Soc. 2006 Dec 20; 128(50):16286-96. PMID: 17165783; PMCID: PMC2525615.
    66. Gianneschi N, Masar MS, Mirkin CA. Development of a coordination chemistry-based approach for functional supramolecular structures. Acc Chem Res. 2005 Nov; 38(11):825-37. PMID: 16285706.
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    67. Gianneschi N, Nguyen ST, Mirkin CA. Signal amplification and detection via a supramolecular allosteric catalyst. J Am Chem Soc. 2005 Feb 16; 127(6):1644-5. PMID: 15700991.
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    68. Gianneschi N, Cho SH, Nguyen ST, Mirkin CA. Reversibly addressing an allosteric catalyst in situ: catalytic molecular tweezers. Angew Chem Int Ed Engl. 2004 Oct 18; 43(41):5503-7. PMID: 15484249.
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    69. Gianneschi N, Bertin PA, Nguyen ST, Mirkin CA, Zakharov LN, Rheingold AL. A supramolecular approach to an allosteric catalyst. J Am Chem Soc. 2003 Sep 03; 125(35):10508-9. PMID: 12940719.
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    70. Gianneschi N, Mirkin CA, Zakharov LN, Rheingold AL. A tetranuclear heterobimetallic square formed from the cooperative ligand binding properties of square planar and tetrahedral metal centers. Inorg Chem. 2002 Oct 21; 41(21):5326-8. PMID: 12377025.
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