Milan Makale

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentRadiation Medicine and Applied Science
Address9500 Gilman Drive #0819
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    A radiotherapeutic for breast cancer brain metastases
    NIH/NCI R21CA187528Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale M, Kesari S. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2017 Apr 04; 8(14):22370-22384. PMID: 26517684.
      View in: PubMed
    2. Makale M, McDonald CR, Hattangadi-Gluth JA, Kesari S. Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nat Rev Neurol. 2017 Jan; 13(1):52-64. PMID: 27982041.
      View in: PubMed
    3. Mukthavaram R, Ouyang X, Saklecha R, Jiang P, Nomura N, Pingle SC, Guo F, Makale M, Kesari S. Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres. J Transl Med. 2015 Aug 18; 13:269. PMID: 26283544; PMCID: PMC4539675.
    4. Jadin L, Pastorino S, Symons R, Nomura N, Jiang P, Juarez T, Makale M, Kesari S. Hyaluronan expression in primary and secondary brain tumors. Ann Transl Med. 2015 Apr; 3(6):80. PMID: 25992379; PMCID: PMC4416955.
    5. Hartman LL, Crawford JR, Makale M, Milburn M, Joshi S, Salazar AM, Hasenauer B, VandenBerg SR, MacDonald TJ, Durden DL. Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors. J Pediatr Hematol Oncol. 2014 Aug; 36(6):451-7. PMID: 24309609; PMCID: PMC4356196.
    6. Pingle SC, Sultana Z, Pastorino S, Jiang P, Mukthavaram R, Chao Y, Bharati IS, Nomura N, Makale M, Abbasi T, Kapoor S, Kumar A, Usmani S, Agrawal A, Vali S, Kesari S. In silico modeling predicts drug sensitivity of patient-derived cancer cells. J Transl Med. 2014 May 21; 12:128. PMID: 24884660; PMCID: PMC4030016.
    7. Nomura N, Pastorino S, Jiang P, Lambert G, Crawford JR, Gymnopoulos M, Piccioni D, Juarez T, Pingle SC, Makale M, Kesari S. Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases. Cancer Cell Int. 2014 Mar 20; 14(1):26. PMID: 24645697; PMCID: PMC3994554.
    8. Jiang P, Mukthavaram R, Mukthavavam R, Chao Y, Bharati IS, Fogal V, Pastorino S, Cong X, Nomura N, Gallagher M, Abbasi T, Vali S, Pingle SC, Makale M, Kesari S. Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs. J Transl Med. 2014 Jan 17; 12:13. PMID: 24433351; PMCID: PMC3898565.
    9. Jiang P, Xue D, Zhang Y, Ye L, Liu Y, Makale M, Kesari S, Edgington TS, Liu C. The extrinsic coagulation cascade and tissue factor pathway inhibitor in macrophages: a potential therapeutic opportunity for atherosclerotic thrombosis. Thromb Res. 2014 Apr; 133(4):657-66. PMID: 24485401.
      View in: PubMed
    10. Muh CR, Joshi S, Singh AR, Kesari S, Durden DL, Makale M. PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1a suppression. J Neurooncol. 2014 Jan; 116(1):89-97. PMID: 24162827; PMCID: PMC3896301.
    11. Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S. High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile. Int J Nanomedicine. 2013; 8:3991-4006. PMID: 24174874; PMCID: PMC3808212.
    12. De P, Dey N, Terakedis B, Bergsagel PL, Li ZH, Mahadevan D, Garlich JR, Trudel S, Makale M, Durden DL. An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo. Cancer Chemother Pharmacol. 2013 Apr; 71(4):867-81. PMID: 23355037; PMCID: PMC3832139.
    13. Sandoval S, Yang J, Alfaro JG, Liberman A, Makale M, Chiang CE, Schuller IK, Kummel AC, Trogler WC. Europium Doped TiO(2) Hollow Nanoshells: Two-Photon Imaging of Cell Binding. Chem Mater. 2012 Nov 13; 24(21):4222-4230. PMID: 23185106.
      View in: PubMed
    14. Chao Y, Makale M, Karmali PP, Sharikov Y, Tsigelny I, Merkulov S, Kesari S, Wrasidlo W, Ruoslahti E, Simberg D. Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains. Bioconjug Chem. 2012 May 16; 23(5):1003-9. PMID: 22515422; PMCID: PMC3444675.
    15. Corle C, Makale M, Kesari S. Cell phones and glioma risk: a review of the evidence. J Neurooncol. 2012 Jan; 106(1):1-13. PMID: 21853424.
      View in: PubMed
    16. Mukthavaram R, Wrasidlo W, Hall D, Kesari S, Makale M. Assembly and targeting of liposomal nanoparticles encapsulating quantum dots. Bioconjug Chem. 2011 Aug 17; 22(8):1638-44. PMID: 21786821; PMCID: PMC3160765.
    17. Yang J, Sandoval S, Alfaro JG, Aschemeyer S, Liberman A, Martin DT, Makale M, Kummel AC, Trogler WC. Red-luminescent europium (III) doped silica nanoshells: synthesis, characterization, and their interaction with HeLa cells. J Biomed Opt. 2011 Jun; 16(6):066012. PMID: 21721813.
      View in: PubMed
    18. Wong K, Young GS, Makale M, Hu X, Yildirim N, Cui K, Wong ST, Kesari S. Characterization of a human tumorsphere glioma orthotopic model using magnetic resonance imaging. J Neurooncol. 2011 Sep; 104(2):473-81. PMID: 21240539; PMCID: PMC3161186.
    19. Erten A, Hall D, Hoh C, Tran Cao HS, Kaushal S, Esener S, Hoffman RM, Bouvet M, Chen J, Kesari S, Makale M. Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging. J Biomed Opt. 2010 Nov-Dec; 15(6):066012. PMID: 21198186; PMCID: PMC3014225.
    20. Erten A, Wrasidlo W, Scadeng M, Esener S, Hoffman RM, Bouvet M, Makale M. Magnetic resonance and fluorescence imaging of doxorubicin-loaded nanoparticles using a novel in vivo model. Nanomedicine. 2010 Dec; 6(6):797-807. PMID: 20599526; PMCID: PMC2980586.
    21. Makale M, McElroy M, O'Brien P, Hoffman RM, Guo S, Bouvet M, Barnes L, Ingulli E, Cheresh D. Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue. J Biomed Opt. 2009 Mar-Apr; 14(2):024032. PMID: 19405761; PMCID: PMC3098575.
    22. Murphy EA, Majeti BK, Barnes LA, Makale M, Weis SM, Lutu-Fuga K, Wrasidlo W, Cheresh DA. Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9343-8. PMID: 18607000; PMCID: PMC2453735.
    23. Makale M. Chapter 8. Noninvasive imaging of blood vessels. Methods Enzymol. 2008; 444:175-99. PMID: 19007665.
      View in: PubMed
    24. Makale M. Cellular mechanobiology and cancer metastasis. Birth Defects Res C Embryo Today. 2007 Dec; 81(4):329-43. PMID: 18228263.
      View in: PubMed
    25. Makale M. Intravital imaging and cell invasion. Methods Enzymol. 2007; 426:375-401. PMID: 17697892.
      View in: PubMed
    26. Garmy-Susini B, Makale M, Fuster M, Varner JA. Methods to study lymphatic vessel integrins. Methods Enzymol. 2007; 426:415-38. PMID: 17697894.
      View in: PubMed
    27. Makale M, Chen PC, Gough DA. Variants of the tissue-sensor array window chamber. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H57-65. PMID: 15734882.
      View in: PubMed
    28. Goel V, Makale M, Grafman J. The hippocampal system mediates logical reasoning about familiar spatial environments. J Cogn Neurosci. 2004 May; 16(4):654-64. PMID: 15165354.
      View in: PubMed
    29. Makale M, Jablecki MC, Gough DA. Mass transfer and gas-phase calibration of implanted oxygen sensors. Anal Chem. 2004 Mar 15; 76(6):1773-7. PMID: 15018582.
      View in: PubMed
    30. Makale M, Lin JT, Calou RE, Tsai AG, Chen PC, Gough DA. Tissue window chamber system for validation of implanted oxygen sensors. Am J Physiol Heart Circ Physiol. 2003 Jun; 284(6):H2288-94. PMID: 12598234.
      View in: PubMed
    31. Wood JN, Romero SG, Makale M, Grafman J. Category-specific representations of social and nonsocial knowledge in the human prefrontal cortex. J Cogn Neurosci. 2003 Feb 15; 15(2):236-48. PMID: 12676061.
      View in: PubMed
    32. Xu B, Grafman J, Gaillard WD, Spanaki M, Ishii K, Balsamo L, Makale M, Theodore WH. Neuroimaging reveals automatic speech coding during perception of written word meaning. Neuroimage. 2002 Oct; 17(2):859-70. PMID: 12377160.
      View in: PubMed
    33. Makale M, Solomon J, Patronas NJ, Danek A, Butman JA, Grafman J. Quantification of brain lesions using interactive automated software. Behav Res Methods Instrum Comput. 2002 Feb; 34(1):6-18. PMID: 12060992.
      View in: PubMed