David Kleinfeld

Title(s)Professor, Physics
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    A web-based framework for multi-modal visualization and annotation of neuroanatomical data
    NIH RF1MH128776Sep 16, 2021 - Sep 14, 2024
    Role: Co-Principal Investigator
    Direct wavefront sensing and adaptive optics to enable two-photon imaging axons and spines throughout all of cortex
    NIH U24EB028942Sep 30, 2019 - Mar 31, 2025
    Role: Principal Investigator
    Reverse Engineering the Brain Stem Circuits that Govern Exploratory Behavior
    NIH U19NS107466Sep 15, 2018 - May 31, 2023
    Role: Principal Investigator
    Resilient versus fragile aspects of blood flow in the mammalian brain
    NIH R35NS097265Dec 1, 2016 - Nov 30, 2024
    Role: Principal Investigator
    Resting state connectivity: Biophysical basis for and improved fMRI measurements
    NIH R01MH111438Sep 16, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Realization of Optical Cell-based Reporters for in vivo Detection of Neuropeptides
    NIH R01MH111499Sep 9, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Ultra-large field two-photon microscope to image transcortical brain dynamics
    NIH R21MH108503May 1, 2015 - Jan 31, 2019
    Role: Principal Investigator
    Optogenetic mapping of synaptic activity and control of intracellular signaling
    NIH U01NS090590Sep 30, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Revealing the connectivity and functionality of brain stem circuits
    NIH U01NS090595Sep 30, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Defining the Logic of Neurovascular Signaling in the Brain
    NIH DP1NS082097Sep 30, 2010 - Jul 31, 2016
    Role: Principal Investigator
    Defining the Logic of Neurovascular Signaling in the Brain
    NIH DP1OD006831Sep 30, 2010 - Jul 31, 2015
    Role: Principal Investigator
    CNiFERs Cell-based Neurotransmitter Fluorescent Engineered Reporters
    NIH R01DA029706Jul 1, 2010 - Apr 30, 2016
    Role: Principal Investigator
    Neuronal Signaling, Network Topology, and Blood Flow Dynamics in Cortex
    NIH R01MH085499Sep 1, 2008 - Jun 30, 2012
    Role: Principal Investigator
    Sentinel cells that report neural and neurovascular signaling
    NIH R21DA024206Sep 20, 2007 - Aug 31, 2010
    Role: Principal Investigator
    Multi-scale mapping of 3D spatial-temporal cortical hemodynamics at the level of
    NIH R21NS059832Jul 1, 2007 - May 31, 2010
    Role: Principal Investigator
    Sensorimotor Loops in Vibrissa Somatosensation
    NIH R01NS058668Mar 1, 2007 - Apr 30, 2018
    Role: Principal Investigator
    Femtosecond Light to Manipulate Neurons and Vasculature
    NIH R21RR021907Sep 15, 2005 - Jul 31, 2009
    Role: Principal Investigator
    All-Optical Histology for 3-D Cortical Reconstructions
    NIH R21MH072570Feb 1, 2005 - Jan 31, 2008
    Role: Principal Investigator
    Manipulating Neural Tissue with Ultra-Short Laser Pulses
    NIH R01EB003832May 1, 2004 - Aug 31, 2017
    Role: Principal Investigator
    NIH R01NS041096Sep 21, 2000 - Aug 31, 2004
    Role: Principal Investigator
    NIH R21RR013419May 15, 2000 - Apr 30, 2003
    Role: Principal Investigator
    NIH R01MH059867May 1, 2000 - Apr 30, 2005
    Role: Principal Investigator
    NIH R13MH057000Jul 25, 1997 - Jun 30, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CellBoost: A pipeline for machine assisted annotation in Neuroanatomy. bioRxiv. 2024 Jan 21. Qian K, Friedman B, Takatoh J, Wang F, Kleinfeld D, Freund Y. PMID: 38293051; PMCID: PMC10827062.
      View in: PubMed   Mentions:
    2. Construction and use of an adaptive optics two-photon microscope with direct wavefront sensing. Nat Protoc. 2023 Dec; 18(12):3732-3766. Yao P, Liu R, Broggini T, Thunemann M, Kleinfeld D. PMID: 37914781.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope. Nature. 2023 Nov; 623(7986):387-396. Lovelace JW, Ma J, Yadav S, Chhabria K, Shen H, Pang Z, Qi T, Sehgal R, Zhang Y, Bali T, Vaissiere T, Tan S, Liu Y, Rumbaugh G, Ye L, Kleinfeld D, Stringer C, Augustine V. PMID: 37914931; PMCID: PMC10632149.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    4. Low- and high-level coordination of orofacial motor actions. Curr Opin Neurobiol. 2023 Dec; 83:102784. Kleinfeld D, Deschênes M, Economo MN, Elbaz M, Golomb D, Liao SM, O'Connor DH, Wang F. PMID: 37757586.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. A lone spike in blood glucose can enhance the thrombo-inflammatory response in cortical venules. J Cereb Blood Flow Metab. 2024 02; 44(2):252-271. Shaked I, Foo C, Mächler P, Liu R, Cui Y, Ji X, Broggini T, Kaminski T, Suryakant Jadhav S, Sundd P, Firer M, Devor A, Friedman B, Kleinfeld D. PMID: 37737093; PMCID: PMC10993879.
      View in: PubMed   Mentions: 1     Fields:    
    6. A brainstem circuit for the expression of defensive facial reactions in rat. Curr Biol. 2023 09 25; 33(18):4030-4035.e3. Callado Pérez A, Demers M, Fassihi A, Moore JD, Kleinfeld D, Deschênes M. PMID: 37703878.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Lawrence Baruch Cohen (1939-2023). Neuron. 2023 Jul 19; 111(14):2123-2125. Kleinfeld D. PMID: 37473724.
      View in: PubMed   Mentions:    Fields:    
    8. A change in behavioral state switches the pattern of motor output that underlies rhythmic head and orofacial movements. Curr Biol. 2023 05 22; 33(10):1951-1966.e6. Liao SM, Kleinfeld D. PMID: 37105167; PMCID: PMC10225163.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Reinforcement learning links spontaneous cortical dopamine impulses to reward. Curr Biol. 2021 09 27; 31(18):4111-4119.e4. Foo C, Lozada A, Aljadeff J, Li Y, Wang JW, Slesinger PA, Kleinfeld D. PMID: 34302743; PMCID: PMC8605927.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations. Elife. 2021 05 20; 10. Li W, Tran V, Shaked I, Xue B, Moore T, Lightle R, Kleinfeld D, Awad IA, Ginsberg MH. PMID: 34013885; PMCID: PMC8175082.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Endothelial struts enable the generation of large lumenized blood vessels de novo. Nat Cell Biol. 2021 04; 23(4):322-329. Weijts B, Shaked I, Ginsberg M, Kleinfeld D, Robin C, Traver D. PMID: 33837285; PMCID: PMC8500358.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon. Neuron. 2021 05 19; 109(10):1721-1738.e4. McElvain LE, Chen Y, Moore JD, Brigidi GS, Bloodgood BL, Lim BK, Costa RM, Kleinfeld D. PMID: 33823137; PMCID: PMC8169061.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    13. Brain microvasculature has a common topology with local differences in geometry that match metabolic load. Neuron. 2021 04 07; 109(7):1168-1187.e13. Ji X, Ferreira T, Friedman B, Liu R, Liechty H, Bas E, Chandrashekar J, Kleinfeld D. PMID: 33657412; PMCID: PMC8525211.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    14. Orofacial Movements Involve Parallel Corticobulbar Projections from Motor Cortex to Trigeminal Premotor Nuclei. Neuron. 2019 11 20; 104(4):765-780.e3. Mercer Lindsay N, Knutsen PM, Lozada AF, Gibbs D, Karten HJ, Kleinfeld D. PMID: 31587918; PMCID: PMC7962749.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    15. Can One Concurrently Record Electrical Spikes from Every Neuron in a Mammalian Brain? Neuron. 2019 09 25; 103(6):1005-1015. Kleinfeld D, Luan L, Mitra PP, Robinson JT, Sarpeshkar R, Shepard K, Xie C, Harris TD. PMID: 31495645; PMCID: PMC6763354.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    16. Direct wavefront sensing enables functional imaging of infragranular axons and spines. Nat Methods. 2019 07; 16(7):615-618. Liu R, Li Z, Marvin JS, Kleinfeld D. PMID: 31209383; PMCID: PMC6763395.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    17. An active texture-based digital atlas enables automated mapping of structures and markers across brains. Nat Methods. 2019 04; 16(4):341-350. Chen Y, McElvain LE, Tolpygo AS, Ferrante D, Friedman B, Mitra PP, Karten HJ, Freund Y, Kleinfeld D. PMID: 30858600; PMCID: PMC6736610.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    18. Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen Level-Dependent Functional Magnetic Resonance Imaging. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 06; 4(6):533-542. Desjardins M, Kiliç K, Thunemann M, Mateo C, Holland D, Ferri CGL, Cremonesi JA, Li B, Cheng Q, Weldy KL, Saisan PA, Kleinfeld D, Komiyama T, Liu TT, Bussell R, Wong EC, Scadeng M, Dunn AK, Boas DA, Sakadžic S, Mandeville JB, Buxton RB, Dale AM, Devor A. PMID: 30691968; PMCID: PMC6556427.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    19. Functional brain stem circuits for control of nose motion. J Neurophysiol. 2019 01 01; 121(1):205-217. Kurnikova A, Deschênes M, Kleinfeld D. PMID: 30461370; PMCID: PMC6383659.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent "Resting-State" Connectivity. Neuron. 2017 Nov 15; 96(4):936-948.e3. Mateo C, Knutsen PM, Tsai PS, Shih AY, Kleinfeld D. PMID: 29107517; PMCID: PMC5851777.
      View in: PubMed   Mentions: 132     Fields:    Translation:Animals
    21. Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions. Neuroscience. 2018 Jan 01; 368:152-170. McElvain LE, Friedman B, Karten HJ, Svoboda K, Wang F, Deschênes M, Kleinfeld D. PMID: 28843993; PMCID: PMC5849401.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    22. Coordination of Orofacial Motor Actions into Exploratory Behavior by Rat. Curr Biol. 2017 Mar 06; 27(5):688-696. Kurnikova A, Moore JD, Liao SM, Deschênes M, Kleinfeld D. PMID: 28216320; PMCID: PMC5653531.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    23. The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements. Philos Trans R Soc Lond B Biol Sci. 2016 10 05; 371(1705). Uhlirova H, Kiliç K, Tian P, Sakadžic S, Gagnon L, Thunemann M, Desjardins M, Saisan PA, Nizar K, Yaseen MA, Hagler DJ, Vandenberghe M, Djurovic S, Andreassen OA, Silva GA, Masliah E, Kleinfeld D, Vinogradov S, Buxton RB, Einevoll GT, Boas DA, Dale AM, Devor A. PMID: 27574309; PMCID: PMC5003857.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    24. Roger Tsien 1952-2016. Nat Neurosci. 2016 09 27; 19(10):1269-70. Kleinfeld D. PMID: 27669983.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Analysis of Neuronal Spike Trains, Deconstructed. Neuron. 2016 07 20; 91(2):221-59. Aljadeff J, Lansdell BJ, Fairhall AL, Kleinfeld D. PMID: 27477016; PMCID: PMC4970242.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    26. Cell type specificity of neurovascular coupling in cerebral cortex. Elife. 2016 05 31; 5. Uhlirova H, Kiliç K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadžic S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vandenberghe M, Cremonesi JA, Ferri CG, Nizar K, Sridhar VB, Steed TC, Abashin M, Fainman Y, Masliah E, Djurovic S, Andreassen OA, Silva GA, Boas DA, Kleinfeld D, Buxton RB, Einevoll GT, Dale AM, Devor A. PMID: 27244241; PMCID: PMC4933561.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    27. Whisking, Sniffing, and the Hippocampal θ-Rhythm: A Tale of Two Oscillators. PLoS Biol. 2016 Feb; 14(2):e1002385. Kleinfeld D, Deschênes M, Ulanovsky N. PMID: 26890361; PMCID: PMC4758648.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    28. Vibrissa Self-Motion and Touch Are Reliably Encoded along the Same Somatosensory Pathway from Brainstem through Thalamus. PLoS Biol. 2015; 13(9):e1002253. Moore JD, Mercer Lindsay N, Deschênes M, Kleinfeld D. PMID: 26393890; PMCID: PMC4579082.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    29. Juxtacellular Monitoring and Localization of Single Neurons within Sub-cortical Brain Structures of Alert, Head-restrained Rats. J Vis Exp. 2015 Apr 27; (98). Moore JD, Deschênes M, Kleinfeld D. PMID: 25938559; PMCID: PMC4541592.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    30. The Brainstem Oscillator for Whisking and the Case for Breathing as the Master Clock for Orofacial Motor Actions. Cold Spring Harb Symp Quant Biol. 2014; 79:29-39. Kleinfeld D, Moore JD, Wang F, Deschênes M. PMID: 25876629; PMCID: PMC4924579.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    31. Deflection of a vibrissa leads to a gradient of strain across mechanoreceptors in a mystacial follicle. J Neurophysiol. 2015 Jul; 114(1):138-45. Whiteley SJ, Knutsen PM, Matthews DW, Kleinfeld D. PMID: 25855692; PMCID: PMC4507969.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    32. Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome. PLoS One. 2015; 10(3):e0119600. Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT. PMID: 25751149; PMCID: PMC4353702.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    33. Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. J Comp Neurol. 2015 Apr 15; 523(6):921-42. Matthews DW, Deschênes M, Furuta T, Moore JD, Wang F, Karten HJ, Kleinfeld D. PMID: 25503925; PMCID: PMC4329057.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    34. Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex. Nat Methods. 2014 Dec; 11(12):1245-52. Muller A, Joseph V, Slesinger PA, Kleinfeld D. PMID: 25344639; PMCID: PMC4245316.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    35. Activation and measurement of free whisking in the lightly anesthetized rodent. Nat Protoc. 2014 Aug; 9(8):1792-802. Moore JD, Deschênes M, Kurnikova A, Kleinfeld D. PMID: 24992095; PMCID: PMC4934662.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    36. More than a rhythm of life: breathing as a binder of orofacial sensation. Nat Neurosci. 2014 May; 17(5):647-51. Kleinfeld D, Deschênes M, Wang F, Moore JD. PMID: 24762718; PMCID: PMC4140942.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    37. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. PMID: 24139032; PMCID: PMC3864648.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    38. ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nat Neurosci. 2013 Oct; 16(10):1499-508. Lin JY, Knutsen PM, Muller A, Kleinfeld D, Tsien RY. PMID: 23995068; PMCID: PMC3793847.
      View in: PubMed   Mentions: 367     Fields:    Translation:HumansAnimalsCells
    39. The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow. Nat Neurosci. 2013 Jul; 16(7):889-97. Blinder P, Tsai PS, Kaufhold JP, Knutsen PM, Suhl H, Kleinfeld D. PMID: 23749145; PMCID: PMC4141079.
      View in: PubMed   Mentions: 272     Fields:    Translation:AnimalsCells
    40. Hierarchy of orofacial rhythms revealed through whisking and breathing. Nature. 2013 May 09; 497(7448):205-10. Moore JD, Deschênes M, Furuta T, Huber D, Smear MC, Demers M, Kleinfeld D. PMID: 23624373; PMCID: PMC4159559.
      View in: PubMed   Mentions: 156     Fields:    Translation:Animals
    41. The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nat Neurosci. 2013 Jan; 16(1):55-63. Shih AY, Blinder P, Tsai PS, Friedman B, Stanley G, Lyden PD, Kleinfeld D. PMID: 23242312; PMCID: PMC3952571.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimals
    42. A polished and reinforced thinned-skull window for long-term imaging of the mouse brain. J Vis Exp. 2012 Mar 07; (61). Shih AY, Mateo C, Drew PJ, Tsai PS, Kleinfeld D. PMID: 22433225; PMCID: PMC3460568.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    43. Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. J Cereb Blood Flow Metab. 2012 Jul; 32(7):1277-309. Shih AY, Driscoll JD, Drew PJ, Nishimura N, Schaffer CB, Kleinfeld D. PMID: 22293983; PMCID: PMC3390800.
      View in: PubMed   Mentions: 226     Fields:    Translation:Animals
    44. Prospect for feedback guided surgery with ultra-short pulsed laser light. Curr Opin Neurobiol. 2012 Feb; 22(1):24-33. Jeong DC, Tsai PS, Kleinfeld D. PMID: 22088392; PMCID: PMC3763077.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    45. Large-scale automated histology in the pursuit of connectomes. J Neurosci. 2011 Nov 09; 31(45):16125-38. Kleinfeld D, Bharioke A, Blinder P, Bock DD, Briggman KL, Chklovskii DB, Denk W, Helmstaedter M, Kaufhold JP, Lee WC, Meyer HS, Micheva KD, Oberlaender M, Prohaska S, Reid RC, Smith SJ, Takemura S, Tsai PS, Sakmann B. PMID: 22072665; PMCID: PMC3758571.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    46. Neuronal basis for object location in the vibrissa scanning sensorimotor system. Neuron. 2011 Nov 03; 72(3):455-68. Kleinfeld D, Deschênes M. PMID: 22078505; PMCID: PMC3971931.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    47. Primary motor cortex reports efferent control of vibrissa motion on multiple timescales. Neuron. 2011 Oct 20; 72(2):344-56. Hill DN, Curtis JC, Moore JD, Kleinfeld D. PMID: 22017992; PMCID: PMC3717360.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    48. Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8473-8. Drew PJ, Shih AY, Kleinfeld D. PMID: 21536897; PMCID: PMC3100929.
      View in: PubMed   Mentions: 153     Fields:    Translation:Animals
    49. A guide to delineate the logic of neurovascular signaling in the brain. Front Neuroenergetics. 2011; 3:1. Kleinfeld D, Blinder P, Drew PJ, Driscoll JD, Muller A, Tsai PS, Shih AY. PMID: 21559095; PMCID: PMC3085135.
      View in: PubMed   Mentions: 47  
    50. Photon counting, censor corrections, and lifetime imaging for improved detection in two-photon microscopy. J Neurophysiol. 2011 Jun; 105(6):3106-13. Driscoll JD, Shih AY, Iyengar S, Field JJ, White GA, Squier JA, Cauwenberghs G, Kleinfeld D. PMID: 21471395; PMCID: PMC3118755.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    51. Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors. PLoS One. 2011 Jan 28; 6(1):e16519. Yamauchi JG, Nemecz Á, Nguyen QT, Muller A, Schroeder LF, Talley TT, Lindstrom J, Kleinfeld D, Taylor P. PMID: 21305050; PMCID: PMC3030600.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    52. Chronic optical access through a polished and reinforced thinned skull. Nat Methods. 2010 Dec; 7(12):981-4. Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai PS, Kleinfeld D. PMID: 20966916; PMCID: PMC3204312.
      View in: PubMed   Mentions: 229     Fields:    Translation:Animals
    53. An in vivo biosensor for neurotransmitter release and in situ receptor activity. Nat Neurosci. 2010 Jan; 13(1):127-132. Nguyen QT, Schroeder LF, Mank M, Muller A, Taylor P, Griesbeck O, Kleinfeld D. PMID: 20010818; PMCID: PMC3992257.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    54. Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci. 2009 Nov 18; 29(46):14553-70. Tsai PS, Kaufhold JP, Blinder P, Friedman B, Drew PJ, Karten HJ, Lyden PD, Kleinfeld D. PMID: 19923289; PMCID: PMC4972024.
      View in: PubMed   Mentions: 271     Fields:    Translation:AnimalsCells
    55. Severe blood-brain barrier disruption and surrounding tissue injury. Stroke. 2009 Dec; 40(12):e666-74. Chen B, Friedman B, Cheng Q, Tsai P, Schim E, Kleinfeld D, Lyden PD. PMID: 19893002; PMCID: PMC2819286.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    56. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest. 2009 Nov; 119(11):3373-83. Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS. PMID: 19809162; PMCID: PMC2769183.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    57. Rapid determination of particle velocity from space-time images using the Radon transform. J Comput Neurosci. 2010 Aug; 29(1-2):5-11. Drew PJ, Blinder P, Cauwenberghs G, Shih AY, Kleinfeld D. PMID: 19459038; PMCID: PMC4962871.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    58. Acute vascular disruption and aquaporin 4 loss after stroke. Stroke. 2009 Jun; 40(6):2182-90. Friedman B, Schachtrup C, Tsai PS, Shih AY, Akassoglou K, Kleinfeld D, Lyden PD. PMID: 19372455; PMCID: PMC2753985.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    59. Phase-to-rate transformations encode touch in cortical neurons of a scanning sensorimotor system. Nat Neurosci. 2009 Apr; 12(4):492-501. Curtis JC, Kleinfeld D. PMID: 19270688; PMCID: PMC2863011.
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    60. Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems. Curr Opin Biotechnol. 2009 Feb; 20(1):90-9. Tsai PS, Blinder P, Migliori BJ, Neev J, Jin Y, Squier JA, Kleinfeld D. PMID: 19269159; PMCID: PMC3123732.
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    61. Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke. J Cereb Blood Flow Metab. 2009 Apr; 29(4):738-51. Shih AY, Friedman B, Drew PJ, Tsai PS, Lyden PD, Kleinfeld D. PMID: 19174826; PMCID: PMC2893883.
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    62. Finding coherence in spontaneous oscillations. Nat Neurosci. 2008 Sep; 11(9):991-3. Drew PJ, Duyn JH, Golanov E, Kleinfeld D. PMID: 18725901.
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    63. Texture coding in the rat whisker system: slip-stick versus differential resonance. PLoS Biol. 2008 Aug 26; 6(8):e215. Wolfe J, Hill DN, Pahlavan S, Drew PJ, Kleinfeld D, Feldman DE. PMID: 18752354; PMCID: PMC2525689.
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    64. Biomechanics of the vibrissa motor plant in rat: rhythmic whisking consists of triphasic neuromuscular activity. J Neurosci. 2008 Mar 26; 28(13):3438-55. Hill DN, Bermejo R, Zeigler HP, Kleinfeld D. PMID: 18367610; PMCID: PMC6670594.
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    65. Wilder Penfield in the age of YouTube: visualizing the sequential activation of sensorimotor areas across neocortex. Neuron. 2007 Dec 06; 56(5):760-2. Kleinfeld D, Waters J. PMID: 18054853.
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    66. Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. J Neurosci. 2007 Apr 18; 27(16):4452-9. Devor A, Tian P, Nishimura N, Teng IC, Hillman EM, Narayanan SN, Ulbert I, Boas DA, Kleinfeld D, Dale AM. PMID: 17442830; PMCID: PMC2680207.
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    67. Active spatial perception in the vibrissa scanning sensorimotor system. PLoS Biol. 2007 Feb; 5(2):e15. Mehta SB, Whitmer D, Figueroa R, Williams BA, Kleinfeld D. PMID: 17227143; PMCID: PMC1769422.
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    68. Large two-photon absorptivity of hemoglobin in the infrared range of 780-880 nm. J Chem Phys. 2007 Jan 14; 126(2):025102. Clay GO, Schaffer CB, Kleinfeld D. PMID: 17228976.
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    69. Penetrating arterioles are a bottleneck in the perfusion of neocortex. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):365-70. Nishimura N, Schaffer CB, Friedman B, Lyden PD, Kleinfeld D. PMID: 17190804; PMCID: PMC1765467.
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    70. Active sensation: insights from the rodent vibrissa sensorimotor system. Curr Opin Neurobiol. 2006 Aug; 16(4):435-44. Kleinfeld D, Ahissar E, Diamond ME. PMID: 16837190.
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    71. Exploratory whisking by rat is not phase locked to the hippocampal theta rhythm. J Neurosci. 2006 Jun 14; 26(24):6518-22. Berg RW, Whitmer D, Kleinfeld D. PMID: 16775139; PMCID: PMC6674030.
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    72. Seeing what the mouse sees with its vibrissae: a matter of behavioral state. Neuron. 2006 May 18; 50(4):524-6. Curtis JC, Kleinfeld D. PMID: 16701202; PMCID: PMC2863010.
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    73. MPScope: a versatile software suite for multiphoton microscopy. J Neurosci Methods. 2006 Sep 30; 156(1-2):351-9. Nguyen QT, Tsai PS, Kleinfeld D. PMID: 16621010.
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    74. Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nat Methods. 2006 Feb; 3(2):99-108. Nishimura N, Schaffer CB, Friedman B, Tsai PS, Lyden PD, Kleinfeld D. PMID: 16432519.
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    75. Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS Biol. 2006 Feb; 4(2):e22. Schaffer CB, Friedman B, Nishimura N, Schroeder LF, Tsai PS, Ebner FF, Lyden PD, Kleinfeld D. PMID: 16379497; PMCID: PMC1324794.
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    76. From art to engineering? The rise of in vivo mammalian electrophysiology via genetically targeted labeling and nonlinear imaging. PLoS Biol. 2005 Oct; 3(10):e355. Kleinfeld D, Griesbeck O. PMID: 16207078; PMCID: PMC1250306.
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    77. Activation of nucleus basalis facilitates cortical control of a brain stem motor program. J Neurophysiol. 2005 Jul; 94(1):699-711. Berg RW, Friedman B, Schroeder LF, Kleinfeld D. PMID: 15728764.
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    78. Positive feedback in a brainstem tactile sensorimotor loop. Neuron. 2005 Feb 03; 45(3):447-57. Nguyen QT, Kleinfeld D. PMID: 15694330.
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    79. Developmental regulation of active and passive membrane properties in rat vibrissa motoneurones. J Physiol. 2004 Apr 01; 556(Pt 1):203-19. Nguyen QT, Wessel R, Kleinfeld D. PMID: 14766934; PMCID: PMC1664878.
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    80. Frisking the whiskers: patterned sensory input in the rat vibrissa system. Neuron. 2004 Jan 22; 41(2):181-4. Mehta SB, Kleinfeld D. PMID: 14741099.
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    81. Reversing cerebellar long-term depression. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15989-93. Lev-Ram V, Mehta SB, Kleinfeld D, Tsien RY. PMID: 14671315; PMCID: PMC307680.
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    82. Imaging reveals synaptic targets of a swim-terminating neuron in the leech CNS. J Neurosci. 2003 Dec 10; 23(36):11402-10. Taylor AL, Cottrell GW, Kleinfeld D, Kristan WB. PMID: 14673004; PMCID: PMC6740517.
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    83. Vibrissa movement elicited by rhythmic electrical microstimulation to motor cortex in the aroused rat mimics exploratory whisking. J Neurophysiol. 2003 Nov; 90(5):2950-63. Berg RW, Kleinfeld D. PMID: 12904336.
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    84. All-optical histology using ultrashort laser pulses. Neuron. 2003 Jul 03; 39(1):27-41. Tsai PS, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. PMID: 12848930.
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    85. Rhythmic whisking by rat: retraction as well as protraction of the vibrissae is under active muscular control. J Neurophysiol. 2003 Jan; 89(1):104-17. Berg RW, Kleinfeld D. PMID: 12522163.
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    86. Spectral mixing of rhythmic neuronal signals in sensory cortex. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15176-81. Ahrens KF, Levine H, Suhl H, Kleinfeld D. PMID: 12403828; PMCID: PMC137563.
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    87. Adaptive filtering of vibrissa input in motor cortex of rat. Neuron. 2002 Jun 13; 34(6):1021-34. Kleinfeld D, Sachdev RN, Merchant LM, Jarvis MR, Ebner FF. PMID: 12086648.
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    88. Coherent electrical activity between vibrissa sensory areas of cerebellum and neocortex is enhanced during free whisking. J Neurophysiol. 2002 Apr; 87(4):2137-48. O'Connor SM, Berg RW, Kleinfeld D. PMID: 11929931.
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    89. Cortical imaging through the intact mouse skull using two-photon excitation laser scanning microscopy. Microsc Res Tech. 2002 Feb 15; 56(4):304-5. Yoder EJ, Kleinfeld D. PMID: 11877806.
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    90. Direct evidence for local oscillatory current sources and intracortical phase gradients in turtle visual cortex. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):877-82. Prechtl JC, Bullock TH, Kleinfeld D. PMID: 10639173; PMCID: PMC15424.
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    91. Dendritic Ca(2+)-activated K(+) conductances regulate electrical signal propagation in an invertebrate neuron. J Neurosci. 1999 Oct 01; 19(19):8319-26. Wessel R, Kristan WB, Kleinfeld D. PMID: 10493733; PMCID: PMC6783054.
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    92. Supralinear summation of synaptic inputs by an invertebrate neuron: dendritic gain is mediated by an "inward rectifier" K(+) current. J Neurosci. 1999 Jul 15; 19(14):5875-88. Wessel R, Kristan WB, Kleinfeld D. PMID: 10407027; PMCID: PMC6783099.
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    93. Identification of neural circuits by imaging coherent electrical activity with FRET-based dyes. Neuron. 1999 Jul; 23(3):449-59. Cacciatore TW, Brodfuehrer PD, Gonzalez JE, Jiang T, Adams SR, Tsien RY, Kristan WB, Kleinfeld D. PMID: 10433258.
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    94. Anatomical loops and their electrical dynamics in relation to whisking by rat. Somatosens Mot Res. 1999; 16(2):69-88. Kleinfeld D, Berg RW, O'Connor SM. PMID: 10449057.
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    95. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15741-6. Kleinfeld D, Mitra PP, Helmchen F, Denk W. PMID: 9861040; PMCID: PMC28114.
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    96. Distributed representation of vibrissa movement in the upper layers of somatosensory cortex revealed with voltage-sensitive dyes. J Comp Neurol. 1996 Nov 04; 375(1):89-108. Kleinfeld D, Delaney KR. PMID: 8913895.
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