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Gen-Sheng Feng

Title(s)Professor, Molecular Biology
SchoolHealth Sciences
Phone858-822-5441
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    Collapse Research 
    Collapse Research Activities and Funding
    Shp2 and Pten in Leukemia and Anemia
    NIH/NHLBI R01HL129763Sep 1, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Dissection of Pten-regulated signals in hepatopathogenesis
    NIH/NCI R01CA188506Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Molecular and cellular communications in liver tumorigenesis
    NIH/NCI R01CA176012Mar 1, 2014 - Feb 29, 2020
    Role: Principal Investigator
    Tyrosine Dephosphorylation and Blood Cell Development
    NIH/NHLBI R01HL096125Aug 17, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Coordinated regulation of signaling events for insulin biosynthesis and secretion
    NIH/NIDDK R01DK075916Jan 15, 2009 - Nov 30, 2013
    Role: Principal Investigator
    Regulation of Leptin Signaling
    NIH/NIDDK R01DK073945Jul 1, 2007 - Jun 30, 2011
    Role: Principal Investigator
    Signaling Interactions in Cell Survival and Invasion
    NIH P01CA102583Sep 22, 2004 - Aug 31, 2010
    Role: Co-Investigator
    GAB2 AND A NOVEL CYTOPLASMIC NUCLEAR SIGNALING MECHANISM
    NIH/NHLBI R01HL066208Jan 1, 2001 - Nov 30, 2005
    Role: Principal Investigator
    Tyrosine dephosphorylation and blood cell development
    NIH/NCI R01CA078606May 1, 1999 - Feb 28, 2009
    Role: Principal Investigator
    Role of the Shp-2 tyrosine phosphatase in signal transdu
    NIH/NIGMS R01GM053660Mar 1, 1996 - Jun 30, 2006
    Role: Principal Investigator
    SYP PHOSPHATASE AND SIGNAL TRANSDUCTION
    NIH/NIGMS R29GM053660Mar 1, 1996 - Feb 28, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wen L, Xin B, Wu P, Lin CH, Peng C, Wang G, Lee J, Lu LF, Feng GS. An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity. Hepatology. 2019 Jan 28. PMID: 30693544.
      View in: PubMed
    2. Qiao L, Chu K, Wattez JS, Lee S, Gao H, Feng GS, Hay WW, Shao J. High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice. Int J Obes (Lond). 2019 Jan 08. PMID: 30622311.
      View in: PubMed
    3. Khambu B, Li T, Yan S, Yu C, Chen X, Goheen M, Li Y, Lin J, Cummings OW, Lee YA, Friedman S, Dong Z, Feng GS, Wu S, Yin XM. Hepatic Autophagy Deficiency Compromises FXR Functionality and Causes Cholestatic Injury. Hepatology. 2018 Dec 05. PMID: 30520052.
      View in: PubMed
    4. Liang Y, Feng Y, Zong M, Wei XF, Lee J, Feng Y, Li H, Yang GS, Wu ZJ, Fu XD, Feng GS. ß-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic ß-catenin and MET. Hepatology. 2018 05; 67(5):1807-1822. PMID: 29152756.
      View in: PubMed
    5. Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic ß-Catenin, PIK3CA and MET. J Hepatol. 2018 Jul; 69(1):79-88. PMID: 29505847.
      View in: PubMed
    6. Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, Shen Y, Wang X, Feng GS, Sun Y, Xu Q. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017 12 18; 8(1):2168. PMID: 29255148.
      View in: PubMed
    7. Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng GS. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Rep. 2017 Nov 14; 21(7):1870-1882. PMID: 29141219.
      View in: PubMed
    8. Cheng J, Zhong Y, Chen S, Sun Y, Huang L, Kang Y, Chen B, Chen G, Wang F, Tian Y, Liu W, Feng GS, Lu Z. Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. FASEB J. 2017 12; 31(12):5530-5542. PMID: 28842424.
      View in: PubMed
    9. Hoople GD, Richards A, Wu Y, Kaneko K, Luo X, Feng GS, Zhang K, Pisano AP. Gel-seq: whole-genome and transcriptome sequencing by simultaneous low-input DNA and RNA library preparation using semi-permeable hydrogel barriers. Lab Chip. 2017 07 25; 17(15):2619-2630. PMID: 28660979.
      View in: PubMed
    10. Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H. Nuclear Shp2 directs normal embryo implantation via facilitating the ERa tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4816-4821. PMID: 28424251.
      View in: PubMed
    11. Liu W, Guo W, Shen L, Chen Z, Luo Q, Luo X, Feng G, Shu Y, Gu Y, Xu Q, Sun Y. T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget. 2017 Jan 31; 8(5):7586-7597. PMID: 27935860.
      View in: PubMed
    12. Liao R, Fu YP, Wang T, Deng ZG, Li DW, Fan J, Zhou J, Feng GS, Qiu SJ, Du CY. Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in China. Oncotarget. 2017 Jan 03; 8(1):1774-1787. PMID: 27662665.
      View in: PubMed
    13. Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng GS. Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. Cell Rep. 2016 12 13; 17(11):2979-2993. PMID: 27974211.
      View in: PubMed
    14. Mathew G, Hannan A, Hertzler-Schaefer K, Wang F, Feng GS, Zhong J, Zhao JJ, Downward J, Zhang X. Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13156-13161. PMID: 27799550.
      View in: PubMed
    15. Gagné-Sansfaçon J, Coulombe G, Langlois MJ, Langlois A, Paquet M, Carrier J, Feng GS, Qu CK, Rivard N. SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development. Oncotarget. 2016 Oct 04; 7(40):65676-65695. PMID: 27582544.
      View in: PubMed
    16. Chen S, Kang Y, Sun Y, Zhong Y, Li Y, Deng L, Tao J, Li Y, Tian Y, Zhao Y, Cheng J, Liu W, Feng GS, Lu Z. Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease. J Mol Cell Biol. 2016 12; 8(6):492-504. PMID: 27282405.
      View in: PubMed
    17. Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). PMID: 27275015.
      View in: PubMed
    18. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. PMID: 26858399; PMCID: PMC4776497.
      View in: PubMed, PubMed Central
    19. Chen WS, Zhu HH, Feng GS. Treating leukemia at the risk of inducing severe anemia. Exp Hematol. 2016 May; 44(5):329-31. PMID: 26826310.
      View in: PubMed
    20. Zhu HH, Luo X, Zhang K, Cui J, Zhao H, Ji Z, Zhou Z, Yao J, Zeng L, Ji K, Gao WQ, Zhang ZY, Feng GS. Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proc Natl Acad Sci U S A. 2015 Oct 27; 112(43):13342-7. PMID: 26460004; PMCID: PMC4629356.
      View in: PubMed, PubMed Central
    21. Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12; 5:12982. PMID: 26265072; PMCID: PMC4533007.
      View in: PubMed, PubMed Central
    22. Kamiya N, Shen J, Noda K, Kitami M, Feng GS, Chen D, Komatsu Y. SHP2-Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice. J Bone Miner Res. 2015 Nov; 30(11):2028-32. PMID: 25919282.
      View in: PubMed
    23. Hanley KL, Feng GS. A new VETC in hepatocellular carcinoma metastasis. Hepatology. 2015 Aug; 62(2):343-5. PMID: 25902918.
      View in: PubMed
    24. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015 Jun; 16(6):642-52. PMID: 25915733; PMCID: PMC4439382.
      View in: PubMed, PubMed Central
    25. Luo T, Fu J, Xu A, Su B, Ren Y, Li N, Zhu J, Zhao X, Dai R, Cao J, Wang B, Qin W, Jiang J, Li J, Wu M, Feng G, Chen Y, Wang H. PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy. 2016 08 02; 12(8):1355-71. PMID: 25905985.
      View in: PubMed
    26. Han T, Xiang DM, Sun W, Liu N, Sun HL, Wen W, Shen WF, Wang RY, Chen C, Wang X, Cheng Z, Li HY, Wu MC, Cong WM, Feng GS, Ding J, Wang HY. PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients. J Hepatol. 2015 Sep; 63(3):651-60. PMID: 25865556.
      View in: PubMed
    27. Su B, Luo T, Zhu J, Fu J, Zhao X, Chen L, Zhang H, Ren Y, Yu L, Yang X, Wu M, Feng G, Li S, Chen Y, Wang H. Interleukin-1ß/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology. 2015 Feb; 61(2):585-97. PMID: 25294684.
      View in: PubMed
    28. Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng GS, Chan RJ. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. J Biol Chem. 2015 Feb 13; 290(7):3894-909. PMID: 25538234; PMCID: PMC4326800.
      View in: PubMed, PubMed Central
    29. Li S, Ni A, Feng GS. Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis. Acta Pharmacol Sin. 2015 Jan; 36(1):113-8. PMID: 25500873; PMCID: PMC4571317.
      View in: PubMed, PubMed Central
    30. Li J, Kang Y, Wei L, Liu W, Tian Y, Chen B, Lin X, Li Y, Feng GS, Lu Z. Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. PLoS One. 2014; 9(7):e102847. PMID: 25048202; PMCID: PMC4105620.
      View in: PubMed, PubMed Central
    31. Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 2014 Aug 05; 20(2):320-32. PMID: 24981838; PMCID: PMC4365973.
      View in: PubMed, PubMed Central
    32. Lee B, Qiao L, Kinney B, Feng GS, Shao J. Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One. 2014; 9(6):e99575. PMID: 24911652; PMCID: PMC4049836.
      View in: PubMed, PubMed Central
    33. Luo X, Feng GS. VEGFA genomic amplification tailors treatment of HCCs with sorafenib. Cancer Discov. 2014 Jun; 4(6):640-1. PMID: 24891362; PMCID: PMC4633301.
      View in: PubMed, PubMed Central
    34. Liu CY, Feng GS. NCOA5, a molecular link between type 2 diabetes and liver cancer. Hepatobiliary Surg Nutr. 2014 Jun; 3(3):106-8. PMID: 25019069; PMCID: PMC4073315.
      View in: PubMed, PubMed Central
    35. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. PMID: 24789228; PMCID: PMC4008632.
      View in: PubMed, PubMed Central
    36. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027; PMCID: PMC4025063.
      View in: PubMed, PubMed Central
    37. Lajiness JD, Snider P, Wang J, Feng GS, Krenz M, Conway SJ. SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):E1374-82. PMID: 24706815; PMCID: PMC3986121.
      View in: PubMed, PubMed Central
    38. Kim HK, Feng GS, Chen D, King PD, Kamiya N. Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions. J Bone Miner Res. 2014 Mar; 29(3):761-9. PMID: 23929766; PMCID: PMC4081537.
      View in: PubMed, PubMed Central
    39. Puri P, Phillips BT, Suzuki H, Orwig KE, Rajkovic A, Lapinski PE, King PD, Feng GS, Walker WH. The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase. Stem Cells. 2014 Mar; 32(3):741-53. PMID: 24123360.
      View in: PubMed
    40. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. PMID: 24531262; PMCID: PMC4077285.
      View in: PubMed, PubMed Central
    41. Chen E, Swift RV, Alderson N, Feher VA, Feng GS, Amaro RE. Computation-guided discovery of influenza endonuclease inhibitors. ACS Med Chem Lett. 2014 Jan 09; 5(1):61-64. PMID: 24490002.
      View in: PubMed
    42. Ng GY, Yeh LK, Zhang Y, Liu H, Feng GS, Kao WW, Liu CY. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Invest Ophthalmol Vis Sci. 2013 Dec 03; 54(13):7933-42. PMID: 24204042; PMCID: PMC3850669.
      View in: PubMed, PubMed Central
    43. He Z, Feng GS. Control of body weight versus tumorigenesis by concerted action of leptin and estrogen. Rev Endocr Metab Disord. 2013 Dec; 14(4):339-45. PMID: 24142297.
      View in: PubMed
    44. Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X. Frs2a and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 01; 127(Pt 3):571-82. PMID: 24284065; PMCID: PMC4007765.
      View in: PubMed, PubMed Central
    45. Kim HK, Aruwajoye O, Sucato D, Richards BS, Feng GS, Chen D, King PD, Kamiya N. Induction of SHP2 deficiency in chondrocytes causes severe scoliosis and kyphosis in mice. Spine (Phila Pa 1976). 2013 Oct 01; 38(21):E1307-12. PMID: 23873233; PMCID: PMC3864111.
      View in: PubMed, PubMed Central
    46. Lapinski PE, Meyer MF, Feng GS, Kamiya N, King PD. Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice. Dis Model Mech. 2013 Nov; 6(6):1448-58. PMID: 24077964; PMCID: PMC3820267.
      View in: PubMed, PubMed Central
    47. Zheng L, Yang W, Wu F, Wang C, Yu L, Tang L, Qiu B, Li Y, Guo L, Wu M, Feng G, Zou D, Wang H. Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. Clin Cancer Res. 2013 Oct 01; 19(19):5372-80. PMID: 23942093.
      View in: PubMed
    48. Wen W, Han T, Chen C, Huang L, Sun W, Wang X, Chen SZ, Xiang DM, Tang L, Cao D, Feng GS, Wu MC, Ding J, Wang HY. Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. Mol Cancer Ther. 2013 Sep; 12(9):1796-804. PMID: 23804702.
      View in: PubMed
    49. Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F, Zhang X. Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development. 2013 Jul; 140(13):2711-23. PMID: 23720040; PMCID: PMC3678341.
      View in: PubMed, PubMed Central
    50. Coulombe G, Leblanc C, Cagnol S, Maloum F, Lemieux E, Perreault N, Feng GS, Boudreau F, Rivard N. Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Mol Cell Biol. 2013 Jun; 33(11):2275-84. PMID: 23530062; PMCID: PMC3648065.
      View in: PubMed, PubMed Central
    51. Chen H, Luo Z, Dong L, Tan Y, Yang J, Feng G, Wu M, Li Z, Wang H. CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival. PLoS One. 2013; 8(2):e56878. PMID: 23437259; PMCID: PMC3577658.
      View in: PubMed, PubMed Central
    52. Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3137-42. PMID: 23382182; PMCID: PMC3581884.
      View in: PubMed, PubMed Central
    53. Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem. 2013 Feb 08; 288(6):3823-30. PMID: 23269672; PMCID: PMC3567637.
      View in: PubMed, PubMed Central
    54. Broxmeyer HE, Etienne-Julan M, Gotoh A, Braun SE, Lu L, Cooper S, Feng GS, Li XJ, Chan RJ. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. Stem Cells Dev. 2013 Mar 15; 22(6):998-1006. PMID: 23082805; PMCID: PMC3585482.
      View in: PubMed, PubMed Central
    55. He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):E79-88. PMID: 23236157.
      View in: PubMed
    56. Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology. 2012 Dec; 56(6):2255-67. PMID: 22898879.
      View in: PubMed
    57. Haglund E, Sulkowska JI, He Z, Feng GS, Jennings PA, Onuchic JN. The unique cysteine knot regulates the pleotropic hormone leptin. PLoS One. 2012; 7(9):e45654. PMID: 23029163; PMCID: PMC3454405.
      View in: PubMed, PubMed Central
    58. Li S, Hsu DD, Wang H, Feng GS. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis. Front Med. 2012 Sep; 6(3):275-9. PMID: 22869052.
      View in: PubMed
    59. Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, Kapur R. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 2012 Sep 27; 120(13):2669-78. PMID: 22806893; PMCID: PMC3460688.
      View in: PubMed, PubMed Central
    60. Huang H, Woo AJ, Waldon Z, Schindler Y, Moran TB, Zhu HH, Feng GS, Steen H, Cantor AB. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 2012 Jul 15; 26(14):1587-601. PMID: 22759635; PMCID: PMC3404386.
      View in: PubMed, PubMed Central
    61. Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun. 2012 Jun 19; 3:911. PMID: 22713753.
      View in: PubMed
    62. Yang W, Wang C, Lin Y, Liu Q, Yu LX, Tang L, Yan HX, Fu J, Chen Y, Zhang HL, Tang L, Zheng LY, He YQ, Li YQ, Wu FQ, Zou SS, Li Z, Wu MC, Feng GS, Wang HY. OV6? tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J Hepatol. 2012 Sep; 57(3):613-20. PMID: 22612999.
      View in: PubMed
    63. Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng GS, Hartmann K, Roers A, Craig AW. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol. 2012 Jul; 32(14):2653-63. PMID: 22566685; PMCID: PMC3416204.
      View in: PubMed, PubMed Central
    64. Wen W, Ding J, Sun W, Fu J, Chen Y, Wu K, Ning B, Han T, Huang L, Chen C, Xie D, Li Z, Feng G, Wu M, Xie W, Wang H. Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. Hepatology. 2012 Jun; 55(6):1787-98. PMID: 22271581.
      View in: PubMed
    65. He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol Cell Biol. 2012 May; 32(10):1867-78. PMID: 22431513; PMCID: PMC3347413.
      View in: PubMed, PubMed Central
    66. Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, Wang HY. p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology. 2012 Jun; 142(7):1547-58.e14. PMID: 22387393.
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    67. Zhang X, Zhang Y, Tao B, Teng L, Li Y, Cao R, Gui Q, Ye M, Mou X, Cheng H, Hu H, Zhou R, Wu X, Xie Q, Ning W, Lai M, Shen H, Feng GS, Ke Y. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB J. 2012 Jun; 26(6):2338-50. PMID: 22362894.
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    68. Feng GS. Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. Cancer Cell. 2012 Feb 14; 21(2):150-4. PMID: 22340589; PMCID: PMC3285429.
      View in: PubMed, PubMed Central
    69. Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng GS, Zhang DE. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood. 2012 Mar 29; 119(13):3155-63. PMID: 22223820; PMCID: PMC3321875.
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    70. Sun W, Ding J, Wu K, Ning BF, Wen W, Sun HY, Han T, Huang L, Dong LW, Yang W, Deng X, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells. Hepatology. 2011 Oct; 54(4):1259-72. PMID: 21735473.
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    71. Liu D, Kong G, Chen QC, Wang G, Li J, Xu Y, lin T, Tian Y, Zhang X, Yao X, Feng G, Lu Z, Chen H. Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. Bioorg Med Chem Lett. 2011 Nov 15; 21(22):6833-7. PMID: 21962577.
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    72. Li L, Chen L, Hu L, Liu Y, Sun HY, Tang J, Hou YJ, Chang YX, Tu QQ, Feng GS, Shen F, Wu MC, Wang HY. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology. 2011 Nov; 54(5):1620-30. PMID: 21809356.
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    73. Zhu HH, Feng GS. The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. Cell Cycle. 2011 Jul 15; 10(14):2241-2. PMID: 21701261; PMCID: PMC3322470.
      View in: PubMed, PubMed Central
    74. Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng GS, Corey SJ. G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Blood. 2011 Jul 28; 118(4):1077-86. PMID: 21636860; PMCID: PMC3148159.
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    75. Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng GS. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell. 2011 May 17; 19(5):629-39. PMID: 21575863; PMCID: PMC3098128.
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    81. Fu J, Chen Y, Cao J, Luo T, Qian YW, Yang W, Ren YB, Su B, Cao GW, Yang Y, Yan YQ, Shen F, Wu MC, Feng GS, Wang HY. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1a pathways. Hepatology. 2011 Jan; 53(1):181-92. PMID: 21254169.
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    85. Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X. Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages. J Immunol. 2010 Jun 01; 184(11):6447-56. PMID: 20435932.
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    87. Cai Z, Feng GS, Zhang X. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. J Neurosci. 2010 Mar 17; 30(11):4110-9. PMID: 20237281; PMCID: PMC2845916.
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    88. Weng T, Mao F, Wang Y, Sun Q, Li R, Yang G, Zhang X, Luo J, Feng GS, Yang X. Osteoblastic molecular scaffold Gab1 is required for maintaining bone homeostasis. J Cell Sci. 2010 Mar 01; 123(Pt 5):682-9. PMID: 20124419.
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    89. McPherson VA, Sharma N, Everingham S, Smith J, Zhu HH, Feng GS, Craig AW. SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells. J Immunol. 2009 Oct 15; 183(8):4940-7. PMID: 19786542.
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    90. Hagihara K, Zhang EE, Ke YH, Liu G, Liu JJ, Rao Y, Feng GS. Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development. Dev Biol. 2009 Oct 01; 334(1):276-84. PMID: 19635473; PMCID: PMC2744846.
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    91. Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7531-6. PMID: 19380737.
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    92. Wu D, Pang Y, Ke Y, Yu J, He Z, Tautz L, Mustelin T, Ding S, Huang Z, Feng GS. A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. PLoS One. 2009; 4(3):e4914. PMID: 19290061; PMCID: PMC2655646.
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    93. Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 2009 Jan 07; 28(1):21-33. PMID: 19057511; PMCID: PMC2633077.
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    94. Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol. 2009 Jan; 29(2):378-88. PMID: 19001090; PMCID: PMC2612510.
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    95. Mitra S, Beach C, Feng GS, Plattner R. SHP-2 is a novel target of Abl kinases during cell proliferation. J Cell Sci. 2008 Oct 15; 121(Pt 20):3335-46. PMID: 18827006; PMCID: PMC2681299.
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    96. Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, Chen Y. Characterization of the topology and functional domains of RKTG. Biochem J. 2008 Sep 15; 414(3):399-406. PMID: 18547165.
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    97. Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, Hobbs PD, Jong L, Waleh N, Chao WR, Feng GS, Pang Y, Su Y. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity. J Med Chem. 2008 Sep 25; 51(18):5650-62. PMID: 18759424; PMCID: PMC4097887.
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    98. Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol. 2008 May; 172(5):1312-24. PMID: 18403587; PMCID: PMC2329840.
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    99. Pan Y, Carbe C, Powers A, Zhang EE, Esko JD, Grobe K, Feng GS, Zhang X. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development. 2008 Jan; 135(2):301-10. PMID: 18077586.
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    100. Ruhul Amin AR, Uddin Biswas MH, Senga T, Feng GS, Kannagi R, Agarwal ML, Hamaguchi M. A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9. Genes Cells. 2007 Sep; 12(9):1023-33. PMID: 17825046.
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    101. Ke Y, Zhang EE, Hagihara K, Wu D, Pang Y, Klein R, Curran T, Ranscht B, Feng GS. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol. 2007 Oct; 27(19):6706-17. PMID: 17646384; PMCID: PMC2099234.
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    102. Amin AR, Thakur VS, Paul RK, Feng GS, Qu CK, Mukhtar H, Agarwal ML. SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5419-24. PMID: 17369354; PMCID: PMC1838507.
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    103. Ni S, Zhao C, Feng GS, Paulson RF, Correll PH. A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection. Mol Cell Biol. 2007 May; 27(10):3708-15. PMID: 17353274; PMCID: PMC1899994.
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    104. Feng GS. Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. Cell Res. 2007 Jan; 17(1):37-41. PMID: 17211446.
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    105. An H, Zhao W, Hou J, Zhang Y, Xie Y, Zheng Y, Xu H, Qian C, Zhou J, Yu Y, Liu S, Feng G, Cao X. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity. 2006 Dec; 25(6):919-28. PMID: 17157040.
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    106. Nguyen TV, Ke Y, Zhang EE, Feng GS. Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. J Immunol. 2006 Nov 01; 177(9):5990-6. PMID: 17056523.
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    107. Chan RJ, Feng GS. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood. 2007 Feb 01; 109(3):862-7. PMID: 17053061; PMCID: PMC1785139.
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    108. Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS. Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J Biol Chem. 2006 Nov 10; 281(45):34374-80. PMID: 16959766; PMCID: PMC1761121.
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    109. Dong XP, Li XM, Gao TM, Zhang EE, Feng GS, Xiong WC, Mei L. Shp2 is dispensable in the formation and maintenance of the neuromuscular junction. Neurosignals. 2006-2007; 15(2):53-63. PMID: 16837792.
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    110. Bard-Chapeau EA, Yuan J, Droin N, Long S, Zhang EE, Nguyen TV, Feng GS. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol. 2006 Jun; 26(12):4664-74. PMID: 16738330; PMCID: PMC1489129.
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    111. Feng GS. Shp2 as a therapeutic target for leptin resistance and obesity. Expert Opin Ther Targets. 2006 Feb; 10(1):135-42. PMID: 16441233.
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    112. Xu R, Yu Y, Zheng S, Zhao X, Dong Q, He Z, Liang Y, Lu Q, Fang Y, Gan X, Xu X, Zhang S, Dong Q, Zhang X, Feng GS. Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. Blood. 2005 Nov 01; 106(9):3142-9. PMID: 16030196; PMCID: PMC1895328.
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    113. Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med. 2005 May; 11(5):567-71. PMID: 15821749.
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    114. Zhang EE, Chapeau E, Hagihara K, Feng GS. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A. 2004 Nov 09; 101(45):16064-9. PMID: 15520383; PMCID: PMC528739.
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    115. Sun Y, Yuan J, Liu H, Shi Z, Baker K, Vuori K, Wu J, Feng GS. Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis. Mol Cell Biol. 2004 Feb; 24(4):1531-9. PMID: 14749370; PMCID: PMC344197.
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    116. Chan RJ, You M, Feng GS. Identification of trans-acting factors by electrophoretic mobility shift assay. Methods Mol Biol. 2004; 249:7-20. PMID: 14573887.
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    117. Ruhul Amin AR, Oo ML, Senga T, Suzuki N, Feng GS, Hamaguchi M. SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix metalloproteinase 2 via the extracellular signal-regulated kinase and p38 pathways. Cancer Res. 2003 Oct 01; 63(19):6334-9. PMID: 14559821.
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    118. Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem. 2003 Sep 05; 278(36):34641-53. PMID: 12819203.
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    119. Chan RJ, Johnson SA, Li Y, Yoder MC, Feng GS. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood. 2003 Sep 15; 102(6):2074-80. PMID: 12791646.
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    120. MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP. The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts. J Biol Chem. 2003 Jul 18; 278(29):27190-8. PMID: 12721296.
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    121. Chen Y, Wen R, Yang S, Schuman J, Zhang EE, Yi T, Feng GS, Wang D. Identification of Shp-2 as a Stat5A phosphatase. J Biol Chem. 2003 May 09; 278(19):16520-7. PMID: 12615921.
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    122. Wu TR, Hong YK, Wang XD, Ling MY, Dragoi AM, Chung AS, Campbell AG, Han ZY, Feng GS, Chin YE. SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J Biol Chem. 2002 Dec 06; 277(49):47572-80. PMID: 12270932.
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    123. Shen R, Ouyang YB, Qu CK, Alonso A, Sperzel L, Mustelin T, Kaplan MH, Feng GS. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol Cell Biol. 2002 May; 22(10):3230-6. PMID: 11971956; PMCID: PMC133801.
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