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Gen-Sheng Feng

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0864
La Jolla CA 92093
Phone858-822-5441
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Shp2 and Pten in Leukemia and Anemia
    NIH/NHLBI R01HL129763Sep 1, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Dissection of Pten-regulated signals in hepatopathogenesis
    NIH/NCI R01CA188506Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Molecular and cellular communications in liver tumorigenesis
    NIH/NCI R01CA176012Mar 1, 2014 - Feb 28, 2019
    Role: Principal Investigator
    Tyrosine Dephosphorylation and Blood Cell Development
    NIH/NHLBI R01HL096125Aug 17, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Coordinated regulation of signaling events for insulin biosynthesis and secretion
    NIH/NIDDK R01DK075916Jan 15, 2009 - Nov 30, 2013
    Role: Principal Investigator
    Regulation of Leptin Signaling
    NIH/NIDDK R01DK073945Jul 1, 2007 - Jun 30, 2011
    Role: Principal Investigator
    Signaling Interactions in Cell Survival and Invasion
    NIH P01CA102583Sep 22, 2004 - Aug 31, 2010
    Role: Co-Investigator
    GAB2 AND A NOVEL CYTOPLASMIC NUCLEAR SIGNALING MECHANISM
    NIH/NHLBI R01HL066208Jan 1, 2001 - Nov 30, 2005
    Role: Principal Investigator
    Tyrosine dephosphorylation and blood cell development
    NIH/NCI R01CA078606May 1, 1999 - Feb 28, 2009
    Role: Principal Investigator
    Role of the Shp-2 tyrosine phosphatase in signal transdu
    NIH/NIGMS R01GM053660Mar 1, 1996 - Jun 30, 2006
    Role: Principal Investigator
    SYP PHOSPHATASE AND SIGNAL TRANSDUCTION
    NIH/NIGMS R29GM053660Mar 1, 1996 - Feb 28, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Liang Y, Feng Y, Zong M, Wei XF, Lee J, Feng Y, Li H, Yang GS, Wu ZJ, Fu XD, Feng GS. ß-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic ß-catenin and MET. Hepatology. 2018 May; 67(5):1807-1822. PMID: 29152756.
      View in: PubMed
    2. Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic ß-Catenin, PIK3CA and MET. J Hepatol. 2018 Mar 02. PMID: 29505847.
      View in: PubMed
    3. Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, Shen Y, Wang X, Feng GS, Sun Y, Xu Q. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017 Dec 18; 8(1):2168. PMID: 29255148.
      View in: PubMed
    4. Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng GS. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Rep. 2017 Nov 14; 21(7):1870-1882. PMID: 29141219.
      View in: PubMed
    5. Cheng J, Zhong Y, Chen S, Sun Y, Huang L, Kang Y, Chen B, Chen G, Wang F, Tian Y, Liu W, Feng GS, Lu Z. Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. FASEB J. 2017 12; 31(12):5530-5542. PMID: 28842424.
      View in: PubMed
    6. Hoople GD, Richards A, Wu Y, Kaneko K, Luo X, Feng GS, Zhang K, Pisano AP. Gel-seq: whole-genome and transcriptome sequencing by simultaneous low-input DNA and RNA library preparation using semi-permeable hydrogel barriers. Lab Chip. 2017 07 25; 17(15):2619-2630. PMID: 28660979.
      View in: PubMed
    7. Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H. Nuclear Shp2 directs normal embryo implantation via facilitating the ERa tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4816-4821. PMID: 28424251.
      View in: PubMed
    8. Liu W, Guo W, Shen L, Chen Z, Luo Q, Luo X, Feng G, Shu Y, Gu Y, Xu Q, Sun Y. T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget. 2017 Jan 31; 8(5):7586-7597. PMID: 27935860.
      View in: PubMed
    9. Liao R, Fu YP, Wang T, Deng ZG, Li DW, Fan J, Zhou J, Feng GS, Qiu SJ, Du CY. Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in China. Oncotarget. 2017 Jan 03; 8(1):1774-1787. PMID: 27662665.
      View in: PubMed
    10. Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng GS. Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. Cell Rep. 2016 12 13; 17(11):2979-2993. PMID: 27974211.
      View in: PubMed
    11. Mathew G, Hannan A, Hertzler-Schaefer K, Wang F, Feng GS, Zhong J, Zhao JJ, Downward J, Zhang X. Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13156-13161. PMID: 27799550.
      View in: PubMed
    12. Gagné-Sansfaçon J, Coulombe G, Langlois MJ, Langlois A, Paquet M, Carrier J, Feng GS, Qu CK, Rivard N. SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development. Oncotarget. 2016 Oct 04; 7(40):65676-65695. PMID: 27582544.
      View in: PubMed
    13. Chen S, Kang Y, Sun Y, Zhong Y, Li Y, Deng L, Tao J, Li Y, Tian Y, Zhao Y, Cheng J, Liu W, Feng GS, Lu Z. Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease. J Mol Cell Biol. 2016 Dec; 8(6):492-504. PMID: 27282405.
      View in: PubMed
    14. Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). PMID: 27275015.
      View in: PubMed
    15. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. PMID: 26858399; PMCID: PMC4776497.
    16. Chen WS, Zhu HH, Feng GS. Treating leukemia at the risk of inducing severe anemia. Exp Hematol. 2016 May; 44(5):329-31. PMID: 26826310.
      View in: PubMed
    17. Zhu HH, Luo X, Zhang K, Cui J, Zhao H, Ji Z, Zhou Z, Yao J, Zeng L, Ji K, Gao WQ, Zhang ZY, Feng GS. Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proc Natl Acad Sci U S A. 2015 Oct 27; 112(43):13342-7. PMID: 26460004; PMCID: PMC4629356.
    18. Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12; 5:12982. PMID: 26265072; PMCID: PMC4533007.
    19. Kamiya N, Shen J, Noda K, Kitami M, Feng GS, Chen D, Komatsu Y. SHP2-Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice. J Bone Miner Res. 2015 Nov; 30(11):2028-32. PMID: 25919282.
      View in: PubMed
    20. Hanley KL, Feng GS. A new VETC in hepatocellular carcinoma metastasis. Hepatology. 2015 Aug; 62(2):343-5. PMID: 25902918.
      View in: PubMed
    21. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015 Jun; 16(6):642-52. PMID: 25915733; PMCID: PMC4439382.
    22. Luo T, Fu J, Xu A, Su B, Ren Y, Li N, Zhu J, Zhao X, Dai R, Cao J, Wang B, Qin W, Jiang J, Li J, Wu M, Feng G, Chen Y, Wang H. PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy. 2016 Aug 02; 12(8):1355-71. PMID: 25905985; PMCID: PMC4968225.
    23. Han T, Xiang DM, Sun W, Liu N, Sun HL, Wen W, Shen WF, Wang RY, Chen C, Wang X, Cheng Z, Li HY, Wu MC, Cong WM, Feng GS, Ding J, Wang HY. PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients. J Hepatol. 2015 Sep; 63(3):651-60. PMID: 25865556.
      View in: PubMed
    24. Su B, Luo T, Zhu J, Fu J, Zhao X, Chen L, Zhang H, Ren Y, Yu L, Yang X, Wu M, Feng G, Li S, Chen Y, Wang H. Interleukin-1ß/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology. 2015 Feb; 61(2):585-97. PMID: 25294684.
      View in: PubMed
    25. Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng GS, Chan RJ. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. J Biol Chem. 2015 Feb 13; 290(7):3894-909. PMID: 25538234; PMCID: PMC4326800.
    26. Li S, Ni A, Feng GS. Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis. Acta Pharmacol Sin. 2015 Jan; 36(1):113-8. PMID: 25500873; PMCID: PMC4571317.
    27. Li J, Kang Y, Wei L, Liu W, Tian Y, Chen B, Lin X, Li Y, Feng GS, Lu Z. Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. PLoS One. 2014; 9(7):e102847. PMID: 25048202; PMCID: PMC4105620.
    28. Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 2014 Aug 05; 20(2):320-32. PMID: 24981838; PMCID: PMC4365973.
    29. Lee B, Qiao L, Kinney B, Feng GS, Shao J. Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One. 2014; 9(6):e99575. PMID: 24911652; PMCID: PMC4049836.
    30. Luo X, Feng GS. VEGFA genomic amplification tailors treatment of HCCs with sorafenib. Cancer Discov. 2014 Jun; 4(6):640-1. PMID: 24891362; PMCID: PMC4633301.
    31. Liu CY, Feng GS. NCOA5, a molecular link between type 2 diabetes and liver cancer. Hepatobiliary Surg Nutr. 2014 Jun; 3(3):106-8. PMID: 25019069; PMCID: PMC4073315.
    32. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. PMID: 24789228; PMCID: PMC4008632.
    33. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027; PMCID: PMC4025063.
    34. Lajiness JD, Snider P, Wang J, Feng GS, Krenz M, Conway SJ. SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):E1374-82. PMID: 24706815; PMCID: PMC3986121.
    35. Kim HK, Feng GS, Chen D, King PD, Kamiya N. Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions. J Bone Miner Res. 2014 Mar; 29(3):761-9. PMID: 23929766; PMCID: PMC4081537.
    36. Puri P, Phillips BT, Suzuki H, Orwig KE, Rajkovic A, Lapinski PE, King PD, Feng GS, Walker WH. The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase. Stem Cells. 2014 Mar; 32(3):741-53. PMID: 24123360.
      View in: PubMed
    37. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. PMID: 24531262; PMCID: PMC4077285.
    38. Chen E, Swift RV, Alderson N, Feher VA, Feng GS, Amaro RE. Computation-guided discovery of influenza endonuclease inhibitors. ACS Med Chem Lett. 2014 Jan 09; 5(1):61-64. PMID: 24490002.
      View in: PubMed
    39. Ng GY, Yeh LK, Zhang Y, Liu H, Feng GS, Kao WW, Liu CY. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Invest Ophthalmol Vis Sci. 2013 Dec 03; 54(13):7933-42. PMID: 24204042; PMCID: PMC3850669.
    40. He Z, Feng GS. Control of body weight versus tumorigenesis by concerted action of leptin and estrogen. Rev Endocr Metab Disord. 2013 Dec; 14(4):339-45. PMID: 24142297.
      View in: PubMed
    41. Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X. Frs2a and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 01; 127(Pt 3):571-82. PMID: 24284065; PMCID: PMC4007765.
    42. Kim HK, Aruwajoye O, Sucato D, Richards BS, Feng GS, Chen D, King PD, Kamiya N. Induction of SHP2 deficiency in chondrocytes causes severe scoliosis and kyphosis in mice. Spine (Phila Pa 1976). 2013 Oct 01; 38(21):E1307-12. PMID: 23873233; PMCID: PMC3864111.
    43. Lapinski PE, Meyer MF, Feng GS, Kamiya N, King PD. Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice. Dis Model Mech. 2013 Nov; 6(6):1448-58. PMID: 24077964; PMCID: PMC3820267.
    44. Zheng L, Yang W, Wu F, Wang C, Yu L, Tang L, Qiu B, Li Y, Guo L, Wu M, Feng G, Zou D, Wang H. Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. Clin Cancer Res. 2013 Oct 01; 19(19):5372-80. PMID: 23942093.
      View in: PubMed
    45. Wen W, Han T, Chen C, Huang L, Sun W, Wang X, Chen SZ, Xiang DM, Tang L, Cao D, Feng GS, Wu MC, Ding J, Wang HY. Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. Mol Cancer Ther. 2013 Sep; 12(9):1796-804. PMID: 23804702.
      View in: PubMed
    46. Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F, Zhang X. Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development. 2013 Jul; 140(13):2711-23. PMID: 23720040; PMCID: PMC3678341.
    47. Coulombe G, Leblanc C, Cagnol S, Maloum F, Lemieux E, Perreault N, Feng GS, Boudreau F, Rivard N. Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Mol Cell Biol. 2013 Jun; 33(11):2275-84. PMID: 23530062; PMCID: PMC3648065.
    48. Chen H, Luo Z, Dong L, Tan Y, Yang J, Feng G, Wu M, Li Z, Wang H. CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival. PLoS One. 2013; 8(2):e56878. PMID: 23437259; PMCID: PMC3577658.
    49. Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3137-42. PMID: 23382182; PMCID: PMC3581884.
    50. Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem. 2013 Feb 08; 288(6):3823-30. PMID: 23269672; PMCID: PMC3567637.
    51. Broxmeyer HE, Etienne-Julan M, Gotoh A, Braun SE, Lu L, Cooper S, Feng GS, Li XJ, Chan RJ. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. Stem Cells Dev. 2013 Mar 15; 22(6):998-1006. PMID: 23082805; PMCID: PMC3585482.
    52. He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):E79-88. PMID: 23236157; PMCID: PMC3538237.
    53. Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology. 2012 Dec; 56(6):2255-67. PMID: 22898879.
      View in: PubMed
    54. Haglund E, Sulkowska JI, He Z, Feng GS, Jennings PA, Onuchic JN. The unique cysteine knot regulates the pleotropic hormone leptin. PLoS One. 2012; 7(9):e45654. PMID: 23029163; PMCID: PMC3454405.
    55. Li S, Hsu DD, Wang H, Feng GS. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis. Front Med. 2012 Sep; 6(3):275-9. PMID: 22869052.
      View in: PubMed
    56. Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, Kapur R. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 2012 Sep 27; 120(13):2669-78. PMID: 22806893; PMCID: PMC3460688.
    57. Huang H, Woo AJ, Waldon Z, Schindler Y, Moran TB, Zhu HH, Feng GS, Steen H, Cantor AB. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 2012 Jul 15; 26(14):1587-601. PMID: 22759635; PMCID: PMC3404386.
    58. Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun. 2012 Jun 19; 3:911. PMID: 22713753.
      View in: PubMed
    59. Yang W, Wang C, Lin Y, Liu Q, Yu LX, Tang L, Yan HX, Fu J, Chen Y, Zhang HL, Tang L, Zheng LY, He YQ, Li YQ, Wu FQ, Zou SS, Li Z, Wu MC, Feng GS, Wang HY. OV6? tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J Hepatol. 2012 Sep; 57(3):613-20. PMID: 22612999.
      View in: PubMed
    60. Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng GS, Hartmann K, Roers A, Craig AW. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol. 2012 Jul; 32(14):2653-63. PMID: 22566685; PMCID: PMC3416204.
    61. Wen W, Ding J, Sun W, Fu J, Chen Y, Wu K, Ning B, Han T, Huang L, Chen C, Xie D, Li Z, Feng G, Wu M, Xie W, Wang H. Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. Hepatology. 2012 Jun; 55(6):1787-98. PMID: 22271581.
      View in: PubMed
    62. He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol Cell Biol. 2012 May; 32(10):1867-78. PMID: 22431513; PMCID: PMC3347413.
    63. Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, Wang HY. p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology. 2012 Jun; 142(7):1547-58.e14. PMID: 22387393.
      View in: PubMed
    64. Zhang X, Zhang Y, Tao B, Teng L, Li Y, Cao R, Gui Q, Ye M, Mou X, Cheng H, Hu H, Zhou R, Wu X, Xie Q, Ning W, Lai M, Shen H, Feng GS, Ke Y. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB J. 2012 Jun; 26(6):2338-50. PMID: 22362894.
      View in: PubMed
    65. Feng GS. Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. Cancer Cell. 2012 Feb 14; 21(2):150-4. PMID: 22340589; PMCID: PMC3285429.
    66. Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng GS, Zhang DE. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood. 2012 Mar 29; 119(13):3155-63. PMID: 22223820; PMCID: PMC3321875.
    67. Sun W, Ding J, Wu K, Ning BF, Wen W, Sun HY, Han T, Huang L, Dong LW, Yang W, Deng X, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells. Hepatology. 2011 Oct; 54(4):1259-72. PMID: 21735473.
      View in: PubMed
    68. Liu D, Kong G, Chen QC, Wang G, Li J, Xu Y, lin T, Tian Y, Zhang X, Yao X, Feng G, Lu Z, Chen H. Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. Bioorg Med Chem Lett. 2011 Nov 15; 21(22):6833-7. PMID: 21962577.
      View in: PubMed
    69. Li L, Chen L, Hu L, Liu Y, Sun HY, Tang J, Hou YJ, Chang YX, Tu QQ, Feng GS, Shen F, Wu MC, Wang HY. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology. 2011 Nov; 54(5):1620-30. PMID: 21809356.
      View in: PubMed
    70. Zhu HH, Feng GS. The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. Cell Cycle. 2011 Jul 15; 10(14):2241-2. PMID: 21701261; PMCID: PMC3322470.
    71. Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng GS, Corey SJ. G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Blood. 2011 Jul 28; 118(4):1077-86. PMID: 21636860; PMCID: PMC3148159.
    72. Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng GS. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell. 2011 May 17; 19(5):629-39. PMID: 21575863; PMCID: PMC3098128.
    73. Cai Z, Simons DL, Fu XY, Feng GS, Wu SM, Zhang X. Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul; 31(14):2973-83. PMID: 21576358; PMCID: PMC3133408.
    74. Ruan X, Li Z, Zhang Y, Yang L, Pan Y, Wang Z, Feng GS, Chen Y. Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat. J Cell Mol Med. 2011 Apr; 15(4):763-72. PMID: 20193037; PMCID: PMC3922665.
    75. Zhu HH, Ji K, Alderson N, He Z, Li S, Liu W, Zhang DE, Li L, Feng GS. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood. 2011 May 19; 117(20):5350-61. PMID: 21450902; PMCID: PMC3109710.
    76. Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM, Hamik A, Jain MK, Feng GS, Jin ZG. Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1016-23. PMID: 21372298; PMCID: PMC3094153.
    77. Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Hessling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, Feng GS, Luo J. Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2957-62. PMID: 21282639; PMCID: PMC3041066.
    78. Fu J, Chen Y, Cao J, Luo T, Qian YW, Yang W, Ren YB, Su B, Cao GW, Yang Y, Yan YQ, Shen F, Wu MC, Feng GS, Wang HY. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1a pathways. Hepatology. 2011 Jan; 53(1):181-92. PMID: 21254169.
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