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Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington's Disease mice. bioRxiv. 2025 Feb 08.
Blumenstock S, Arakelyan D, Del Grosso N, Schneider S, Shao Y, Gjoni E, Klein R, Dudanova I, Komiyama T. PMID: 39974900; PMCID: PMC11839025.
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Learning and Control in Motor Cortex across Cell Types and Scales. J Neurosci. 2024 Oct 02; 44(40).
Economo MN, Komiyama T, Kubota Y, Schiller J. PMID: 39358022; PMCID: PMC11459264.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Author Correction: Meta-reinforcement learning via orbitofrontal cortex. Nat Neurosci. 2024 Aug; 27(8):1632.
Hattori R, Hedrick NG, Jain A, Chen S, You H, Hattori M, Choi JH, Lim BK, Yasuda R, Komiyama T. PMID: 38956167; PMCID: PMC11303241.
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PubMed Mentions: Fields:
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Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning. Neuron. 2024 Jun 05; 112(11):1891.
Ren C, Peng K, Yang R, Liu W, Liu C, Komiyama T. PMID: 38754413; PMCID: PMC11197876.
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PubMed Mentions: Fields:
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Local and global predictors of synapse elimination during motor learning. Sci Adv. 2024 Mar 15; 10(11):eadk0540.
Hedrick NG, Wright WJ, Komiyama T. PMID: 38489360; PMCID: PMC10942101.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Divergent Learning-Related Transcriptional States of Cortical Glutamatergic Neurons. J Neurosci. 2024 Mar 06; 44(10).
Dunton KL, Hedrick NG, Meamardoost S, Ren C, Howe JR, Wang J, Root CM, Gunawan R, Komiyama T, Zhang Y, Hwang EJ. PMID: 38238073; PMCID: PMC10919205.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings. Nat Nanotechnol. 2024 Apr; 19(4):504-513.
Ramezani M, Kim JH, Liu X, Ren C, Alothman A, De-Eknamkul C, Wilson MN, Cubukcu E, Gilja V, Komiyama T, Kuzum D. PMID: 38212523; PMCID: PMC11742260.
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PubMed Mentions:
3 Fields:
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Exponential history integration with diverse temporal scales in retrosplenial cortex supports hyperbolic behavior. Sci Adv. 2023 12; 9(48):eadj4897.
Danskin BP, Hattori R, Zhang YE, Babic Z, Aoi M, Komiyama T. PMID: 38019904; PMCID: PMC10686558.
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PubMed Mentions: Fields:
Translation:
Animals
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Meta-reinforcement learning via orbitofrontal cortex. Nat Neurosci. 2023 Dec; 26(12):2182-2191.
Hattori R, Hedrick NG, Jain A, Chen S, You H, Hattori M, Choi JH, Lim BK, Yasuda R, Komiyama T. PMID: 37957318; PMCID: PMC10689244.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Diversity of primate brain cells unraveled. Sci Adv. 2023 10 13; 9(41):eadl0650.
Komiyama T. PMID: 37824624; PMCID: PMC10569699.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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AlphaTracker: a multi-animal tracking and behavioral analysis tool. Front Behav Neurosci. 2023; 17:1111908.
Chen Z, Zhang R, Fang HS, Zhang YE, Bal A, Zhou H, Rock RR, Padilla-Coreano N, Keyes LR, Zhu H, Li YL, Komiyama T, Tye KM, Lu C. PMID: 37324523; PMCID: PMC10266280.
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PubMed Mentions:
23
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Super-resolution with Binary Priors: Theory and Algorithms. IEEE Trans Signal Process. 2023; 71:3213-3228.
Sarangi P, Hattori R, Komiyama T, Pal P. PMID: 38711845; PMCID: PMC11070749.
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PubMed Mentions:
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Deep learning for neural decoding in motor cortex. J Neural Eng. 2022 09 23; 19(5).
Liu F, Meamardoost S, Gunawan R, Komiyama T, Mewes C, Zhang Y, Hwang E, Wang L. PMID: 36148535.
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PubMed Mentions:
1 Fields:
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Learning binds new inputs into functional synaptic clusters via spinogenesis. Nat Neurosci. 2022 06; 25(6):726-737.
Hedrick NG, Lu Z, Bushong E, Singhi S, Nguyen P, Magaña Y, Jilani S, Lim BK, Ellisman M, Komiyama T. PMID: 35654957.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning. Neuron. 2022 07 20; 110(14):2334-2350.e8.
Ren C, Peng K, Yang R, Liu W, Liu C, Komiyama T. PMID: 35584693; PMCID: PMC9308684.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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PatchWarp: Corrections of non-uniform image distortions in two-photon calcium imaging data by patchwork affine transformations. Cell Rep Methods. 2022 05 23; 2(5):100205.
Hattori R, Komiyama T. PMID: 35637910; PMCID: PMC9142688.
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PubMed Mentions:
10 Fields:
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Longitudinal two-photon calcium imaging with ultra-large cranial window for head-fixed mice. STAR Protoc. 2022 06 17; 3(2):101343.
Hattori R, Komiyama T. PMID: 35496806; PMCID: PMC9048142.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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FARCI: Fast and Robust Connectome Inference. Brain Sci. 2021 Nov 24; 11(12).
Meamardoost S, Bhattacharya M, Hwang EJ, Komiyama T, Mewes C, Wang L, Zhang Y, Gunawan R. PMID: 34942857; PMCID: PMC8699247.
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PubMed Mentions:
3
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Context-dependent persistency as a coding mechanism for robust and widely distributed value coding. Neuron. 2022 02 02; 110(3):502-515.e11.
Hattori R, Komiyama T. PMID: 34818514; PMCID: PMC8813889.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Wide-field calcium imaging of cortex-wide activity in awake, head-fixed mice. STAR Protoc. 2021 12 17; 2(4):100973.
Ren C, Komiyama T. PMID: 34849490; PMCID: PMC8608657.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Decoding of cortex-wide brain activity from local recordings of neural potentials. J Neural Eng. 2021 11 15; 18(6).
Liu X, Ren C, Huang Z, Wilson M, Kim JH, Lu Y, Ramezani M, Komiyama T, Kuzum D. PMID: 34706356; PMCID: PMC8643174.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Disengagement of Motor Cortex during Long-Term Learning Tracks the Performance Level of Learned Movements. J Neurosci. 2021 08 18; 41(33):7029-7047.
Hwang EJ, Dahlen JE, Mukundan M, Komiyama T. PMID: 34244359; PMCID: PMC8372014.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging. J Neurosci. 2021 05 12; 41(19):4160-4168.
Ren C, Komiyama T. PMID: 33893217; PMCID: PMC8143209.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
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Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical-hippocampal interactions. Nat Neurosci. 2021 06; 24(6):886-896.
Liu X, Ren C, Lu Y, Liu Y, Kim JH, Leutgeb S, Komiyama T, Kuzum D. PMID: 33875893; PMCID: PMC8627685.
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PubMed Mentions:
26 Fields:
Translation:
Animals
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Autonomous Computing Materials. ACS Nano. 2021 03 23; 15(3):3586-3592.
Bathe M, Hernandez R, Komiyama T, Machiraju R, Neogi S. PMID: 33636971.
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PubMed Mentions:
4 Fields:
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Context-dependent plasticity of adult-born neurons regulated by cortical feedback. Sci Adv. 2020 10; 6(42).
Wu A, Yu B, Chen Q, Matthews GA, Lu C, Campbell E, Tye KM, Komiyama T. PMID: 33067236; PMCID: PMC7567600.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Stability of motor cortex network states during learning-associated neural reorganizations. J Neurophysiol. 2020 11 01; 124(5):1327-1342.
Ma Z, Liu H, Komiyama T, Wessel R. PMID: 32937084; PMCID: PMC8356787.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Evaluation of Durability of Transparent Graphene Electrodes Fabricated on Different Flexible Substrates for Chronic In Vivo Experiments. IEEE Trans Biomed Eng. 2020 11; 67(11):3203-3210.
Ding D, Lu Y, Zhao R, Liu X, De-Eknamkul C, Ren C, Mehrsa A, Komiyama T, Kuzum D. PMID: 32191878; PMCID: PMC8560430.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Plasticity in olfactory bulb circuits. Curr Opin Neurobiol. 2020 10; 64:17-23.
Wu A, Yu B, Komiyama T. PMID: 32062045; PMCID: PMC7423727.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Corticostriatal Flow of Action Selection Bias. Neuron. 2019 12 18; 104(6):1126-1140.e6.
Hwang EJ, Link TD, Hu YY, Lu S, Wang EH, Lilascharoen V, Aronson S, O'Neil K, Lim BK, Komiyama T. PMID: 31706697; PMCID: PMC6923603.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Disengagement of motor cortex from movement control during long-term learning. Sci Adv. 2019 10; 5(10):eaay0001.
Hwang EJ, Dahlen JE, Hu YY, Aguilar K, Yu B, Mukundan M, Mitani A, Komiyama T. PMID: 31693007; PMCID: PMC6821459.
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PubMed Mentions:
30 Fields:
Translation:
Animals
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Area-Specificity and Plasticity of History-Dependent Value Coding During Learning. Cell. 2019 06 13; 177(7):1858-1872.e15.
Hattori R, Danskin B, Babic Z, Mlynaryk N, Komiyama T. PMID: 31080067; PMCID: PMC6663310.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Real-Time Processing of Two-Photon Calcium Imaging Data Including Lateral Motion Artifact Correction. Front Neuroinform. 2018; 12:98.
Mitani A, Komiyama T. PMID: 30618703; PMCID: PMC6305597.
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PubMed Mentions:
26
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Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen Level-Dependent Functional Magnetic Resonance Imaging. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 06; 4(6):533-542.
Desjardins M, Kiliç K, Thunemann M, Mateo C, Holland D, Ferri CGL, Cremonesi JA, Li B, Cheng Q, Weldy KL, Saisan PA, Kleinfeld D, Komiyama T, Liu TT, Bussell R, Wong EC, Scadeng M, Dunn AK, Boas DA, Sakadžic S, Mandeville JB, Buxton RB, Dale AM, Devor A. PMID: 30691968; PMCID: PMC6556427.
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PubMed Mentions:
40 Fields:
Translation:
Animals
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Ultra-low Impedance Graphene Microelectrodes with High Optical Transparency for Simultaneous Deep 2-photon Imaging in Transgenic Mice. Adv Funct Mater. 2018 Aug 01; 28(31).
Lu Y, Liu X, Hattori R, Ren C, Zhang X, Komiyama T, Kuzum D. PMID: 34084100; PMCID: PMC8172040.
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PubMed Mentions:
23
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Adult-born neurons facilitate olfactory bulb pattern separation during task engagement. Elife. 2018 03 13; 7.
Li WL, Chu MW, Wu A, Suzuki Y, Imayoshi I, Komiyama T. PMID: 29533179; PMCID: PMC5912906.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Brain-Computer Interface with Inhibitory Neurons Reveals Subtype-Specific Strategies. Curr Biol. 2018 01 08; 28(1):77-83.e4.
Mitani A, Dong M, Komiyama T. PMID: 29249656; PMCID: PMC5760288.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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History-based action selection bias in posterior parietal cortex. Nat Commun. 2017 11 01; 8(1):1242.
Hwang EJ, Dahlen JE, Mukundan M, Komiyama T. PMID: 29089500; PMCID: PMC5663966.
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PubMed Mentions:
67 Fields:
Translation:
Animals
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Lack of Pattern Separation in Sensory Inputs to the Olfactory Bulb during Perceptual Learning. eNeuro. 2017 Sep-Oct; 4(5).
Chu MW, Li WL, Komiyama T. PMID: 28955724; PMCID: PMC5615249.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Functions and dysfunctions of neocortical inhibitory neuron subtypes. Nat Neurosci. 2017 Aug 29; 20(9):1199-1208.
Hattori R, Kuchibhotla KV, Froemke RC, Komiyama T. PMID: 28849791; PMCID: PMC7082034.
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PubMed Mentions:
63 Fields:
Translation:
HumansCells
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Reorganization of corticospinal output during motor learning. Nat Neurosci. 2017 Aug; 20(8):1133-1141.
Peters AJ, Lee J, Hedrick NG, O'Neil K, Komiyama T. PMID: 28671694; PMCID: PMC5656286.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Neuromodulation in Chemosensory Pathways. Chem Senses. 2017 Jun 01; 42(5):375-379.
McIntyre JC, Thiebaud N, McGann JP, Komiyama T, Rothermel M. PMID: 28379355; PMCID: PMC5863563.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Transformation of Cortex-wide Emergent Properties during Motor Learning. Neuron. 2017 May 17; 94(4):880-890.e8.
Makino H, Ren C, Liu H, Kim AN, Kondapaneni N, Liu X, Kuzum D, Komiyama T. PMID: 28521138; PMCID: PMC5502752.
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PubMed Mentions:
112 Fields:
Translation:
Animals
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Learning in the Rodent Motor Cortex. Annu Rev Neurosci. 2017 07 25; 40:77-97.
Peters AJ, Liu H, Komiyama T. PMID: 28375768; PMCID: PMC5714655.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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Circuit Mechanisms of Sensorimotor Learning. Neuron. 2016 Nov 23; 92(4):705-721.
Makino H, Hwang EJ, Hedrick NG, Komiyama T. PMID: 27883902; PMCID: PMC5131723.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimals
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Balancing the Robustness and Efficiency of Odor Representations during Learning. Neuron. 2016 Oct 05; 92(1):174-186.
Chu MW, Li WL, Komiyama T. PMID: 27667005; PMCID: PMC5061050.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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Learning enhances the relative impact of top-down processing in the visual cortex. Nat Neurosci. 2015 Aug; 18(8):1116-22.
Makino H, Komiyama T. PMID: 26167904; PMCID: PMC4523093.
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PubMed Mentions:
152 Fields:
Translation:
AnimalsCells
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Subtype-specific plasticity of inhibitory circuits in motor cortex during motor learning. Nat Neurosci. 2015 Aug; 18(8):1109-15.
Chen SX, Kim AN, Peters AJ, Komiyama T. PMID: 26098758; PMCID: PMC4519436.
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PubMed Mentions:
152 Fields:
Translation:
AnimalsCells
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Broadcasting of cortical activity to the olfactory bulb. Cell Rep. 2015 Feb 24; 10(7):1032-9.
Boyd AM, Kato HK, Komiyama T, Isaacson JS. PMID: 25704808; PMCID: PMC4342299.
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PubMed Mentions:
47 Fields:
Translation:
Animals
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Emergence of reproducible spatiotemporal activity during motor learning. Nature. 2014 Jun 12; 510(7504):263-7.
Peters AJ, Chen SX, Komiyama T. PMID: 24805237.
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PubMed Mentions:
243 Fields:
Translation:
AnimalsCells
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Procedures for behavioral experiments in head-fixed mice. PLoS One. 2014; 9(2):e88678.
Guo ZV, Hires SA, Li N, O'Connor DH, Komiyama T, Ophir E, Huber D, Bonardi C, Morandell K, Gutnisky D, Peron S, Xu NL, Cox J, Svoboda K. PMID: 24520413; PMCID: PMC3919818.
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PubMed Mentions:
211 Fields:
Translation:
HumansAnimals
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Parvalbumin-expressing interneurons linearly control olfactory bulb output. Neuron. 2013 Dec 04; 80(5):1218-31.
Kato HK, Gillet SN, Peters AJ, Isaacson JS, Komiyama T. PMID: 24239124; PMCID: PMC3884945.
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PubMed Mentions:
110 Fields:
Translation:
AnimalsCells
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Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience. Neuron. 2012 Dec 06; 76(5):962-75.
Kato HK, Chu MW, Isaacson JS, Komiyama T. PMID: 23217744; PMCID: PMC3523713.
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PubMed Mentions:
145 Fields:
Translation:
HumansAnimalsCells
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Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron. 2011 Dec 08; 72(5):734-47.
Sweeney LB, Chou YH, Wu Z, Joo W, Komiyama T, Potter CJ, Kolodkin AL, Garcia KC, Luo L. PMID: 22153371; PMCID: PMC3365565.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice. Nature. 2010 Apr 22; 464(7292):1182-6.
Komiyama T, Sato TR, O'Connor DH, Zhang YX, Huber D, Hooks BM, Gabitto M, Svoboda K. PMID: 20376005.
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PubMed Mentions:
256 Fields:
Translation:
AnimalsCells
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Vibrissa-based object localization in head-fixed mice. J Neurosci. 2010 Feb 03; 30(5):1947-67.
O'Connor DH, Clack NG, Huber D, Komiyama T, Myers EW, Svoboda K. PMID: 20130203; PMCID: PMC6634009.
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PubMed Mentions:
174 Fields:
Translation:
Animals
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Lola regulates Drosophila olfactory projection neuron identity and targeting specificity. Neural Dev. 2007 Jul 16; 2:14.
Spletter ML, Liu J, Liu J, Su H, Giniger E, Komiyama T, Quake S, Luo L. PMID: 17634136; PMCID: PMC1947980.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Intrinsic control of precise dendritic targeting by an ensemble of transcription factors. Curr Biol. 2007 Feb 06; 17(3):278-85.
Komiyama T, Luo L. PMID: 17276922.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell. 2007 Jan 26; 128(2):399-410.
Komiyama T, Sweeney LB, Schuldiner O, Garcia KC, Luo L. PMID: 17254975.
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PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
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Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions. Neuron. 2007 Jan 18; 53(2):185-200.
Sweeney LB, Couto A, Chou YH, Berdnik D, Dickson BJ, Luo L, Komiyama T. PMID: 17224402.
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PubMed Mentions:
86 Fields:
Translation:
AnimalsCells
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Development of wiring specificity in the olfactory system. Curr Opin Neurobiol. 2006 Feb; 16(1):67-73.
Komiyama T, Luo L. PMID: 16377177.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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Development of wiring specificity of the Drosophila olfactory system. Chem Senses. 2005 Jan; 30 Suppl 1:i94.
Jefferis GS, Marin EC, Komiyama T, Zhu H, Chihara T, Berdnik D, Luo L. PMID: 15738213.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions. Nat Neurosci. 2004 Aug; 7(8):819-25.
Komiyama T, Carlson JR, Luo L. PMID: 15247920.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Neuroscience. Calcium and CREST for healthy dendrites. Science. 2004 Jan 09; 303(5655):179-81.
Jefferis GS, Komiyama T, Luo L. PMID: 14715999.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons. Cell. 2003 Jan 24; 112(2):157-67.
Komiyama T, Johnson WA, Luo L, Jefferis GS. PMID: 12553905.
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PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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BET, a novel neuronal transmembrane protein with multiple EGF-like motifs. Neuroreport. 2002 May 07; 13(6):909-15.
Nishizumi H, Komiyama T, Miyabayashi T, Sakano S, Sakano H. PMID: 11997712.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Representation of the glomerular olfactory map in the Drosophila brain. Cell. 2002 Apr 19; 109(2):243-55.
Marin EC, Jefferis GS, Komiyama T, Zhu H, Luo L. PMID: 12007410.
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PubMed Mentions:
189 Fields:
Translation:
AnimalsCells
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Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1410-5.
Lu SM, Lu W, Qasim MA, Anderson S, Apostol I, Ardelt W, Bigler T, Chiang YW, Cook J, James MN, Kato I, Kelly C, Kohr W, Komiyama T, Lin TY, Ogawa M, Otlewski J, Park SJ, Qasim S, Ranjbar M, Tashiro M, Warne N, Whatley H, Wieczorek A, Wieczorek M, Wilusz T, Wynn R, Zhang W, Laskowski M. PMID: 11171964; PMCID: PMC29270.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Cutaneous reflexes during human gait: electromyographic and kinematic responses to electrical stimulation. J Neurophysiol. 1997 Jun; 77(6):3311-25.
Zehr EP, Komiyama T, Stein RB. PMID: 9212277.
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PubMed Mentions:
90 Fields:
Translation:
HumansCells
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A novel yeast gene, RHK1, is involved in the synthesis of the cell wall receptor for the HM-1 killer toxin that inhibits beta-1,3-glucan synthesis. Mol Gen Genet. 1997 Mar 26; 254(2):139-47.
Kimura T, Kitamoto N, Kito Y, Iimura Y, Shirai T, Komiyama T, Furuichi Y, Sakka K, Ohmiya K. PMID: 9108275.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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The differences in human spinal motoneuron excitability during the foreperiod of a motor task. Exp Brain Res. 1990; 79(2):357-64.
Komiyama T, Tanaka R. PMID: 2323381.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells