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Donald Guiney

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0640
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Intestinal Physiology in the Host Response to Enteric Salmonella Infections
    NIH/NIAID R01AI077661Jan 1, 2009 - Dec 31, 2014
    Role: Principal Investigator
    Protection Against Inhalation Anthrax with Inactivated Spores
    NIH/NIAID U01AI077989May 15, 2008 - Apr 30, 2013
    Role: Principal Investigator
    Salmonella-to-Eukaryotic Cell Multi-task Gene Delivery
    NIH/NIAID R03AI064351May 1, 2005 - Apr 30, 2008
    Role: Principal Investigator
    INTERACTIONS OF HELICOBACTER WITH THE GASTRIC MUCOSA
    NIH/NIDDK R01DK053649Sep 30, 1997 - Sep 30, 2003
    Role: Principal Investigator
    HUMAN IMMUNE RESPONSE TO M TUBERCULOSIS LATENCY ANTIGENS
    NIH/NIAID R01AI037005Sep 30, 1994 - Jul 31, 2000
    Role: Principal Investigator
    Plasmid-Mediated Virulence in Salmonella
    NIH/NIAID R56AI032178Sep 1, 1993 - Sep 29, 2011
    Role: Principal Investigator
    Plasmid-Mediated Virulence in Salmonella
    NIH/NIAID R01AI032178Sep 1, 1993 - Nov 30, 2009
    Role: Principal Investigator
    BLACK-PIGMENTED BACTEROIDES--DRUG RESISTANCE &VIRULENCE
    NIH/NIDCR R01DE007344Sep 1, 1985 - Jun 30, 1989
    Role: Principal Investigator
    MECHANISM OF PLASMID DNA TRANSFER IN BACTERIA
    NIH/NIGMS R01GM028924Sep 1, 1980 - Dec 31, 1994
    Role: Principal Investigator
    ANTIBIOTIC RESISTANCE OF BACTEROIDES
    NIH/NIAID R01AI016463Feb 1, 1980 - Apr 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Marchelletta RR, Gareau MG, Okamoto S, Guiney D, Barrett KE, Fierer J. Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation. J Infect Dis. 2015 Jul 01; 212(1):128-36. PMID: 25538271; PMCID: PMC4542593.
    2. Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney D, Corr M, Carson DA, Hayashi T. Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand. J Innate Immun. 2014; 6(3):315-24. PMID: 24192551; PMCID: PMC3972367.
    3. Marchelletta RR, Gareau MG, McCole DF, Okamoto S, Roel E, Klinkenberg R, Guiney D, Fierer J, Barrett KE. Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis. Gastroenterology. 2013 Dec; 145(6):1358-1368.e1-4. PMID: 24001788; PMCID: PMC3899031.
    4. Wanram S, Guiney D, Panomket P, Jearanaikoon P. Activated charcoal enhanced the antigen-expression and dendritic cell maturation of the vaccine using Listeria-platform. Kobe J Med Sci. 2012 Sep 13; 58(3):E63-71. PMID: 23143471.
      View in: PubMed
    5. Preziosi MJ, Kandel SM, Guiney D, Browne SH. Microbiological analysis of nontyphoidal Salmonella strains causing distinct syndromes of bacteremia or enteritis in HIV/AIDS patients in San Diego, California. J Clin Microbiol. 2012 Nov; 50(11):3598-603. PMID: 22933605; PMCID: PMC3486235.
    6. Fierer J, Okamoto S, Banerjee A, Guiney D. Diarrhea and colitis in mice require the Salmonella pathogenicity island 2-encoded secretion function but not SifA or Spv effectors. Infect Immun. 2012 Oct; 80(10):3360-70. PMID: 22778101; PMCID: PMC3457546.
    7. Obonyo M, Rickman B, Guiney D. Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response. Helicobacter. 2011 Oct; 16(5):398-404. PMID: 21923686; PMCID: PMC3535435.
    8. Bowman BN, McAdam PR, Vivona S, Zhang JX, Luong T, Belew RK, Sahota H, Guiney D, Valafar F, Fierer J, Woelk CH. Improving reverse vaccinology with a machine learning approach. Vaccine. 2011 Oct 19; 29(45):8156-64. PMID: 21864619.
      View in: PubMed
    9. Guiney D, Fierer J. The Role of the spv Genes in Salmonella Pathogenesis. Front Microbiol. 2011; 2:129. PMID: 21716657; PMCID: PMC3117207.
    10. van Sorge NM, Zialcita PA, Browne SH, Quach D, Guiney D, Doran KS. Penetration and activation of brain endothelium by Salmonella enterica serovar Typhimurium. J Infect Dis. 2011 Feb 01; 203(3):401-5. PMID: 21186258; PMCID: PMC3071103.
    11. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney D, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. PMID: 20479237; PMCID: PMC2890829.
    12. Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M. NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH. Chem Biol Drug Des. 2010 Jul; 76(1):10-6. PMID: 20456369; PMCID: PMC2905849.
    13. Cellitti J, Zhang Z, Wang S, Wu B, Yuan H, Hasegawa P, Guiney D, Pellecchia M. Small molecule DnaK modulators targeting the beta-domain. Chem Biol Drug Des. 2009 Oct; 74(4):349-57. PMID: 19694756; PMCID: PMC2858402.
    14. McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Zhang DX, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney D, Friedlander AM, Koehler TM, Nizet V. ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis. J Innate Immun. 2009; 1(5):494-506. PMID: 20375606; PMCID: PMC2920483.
    15. Johnson SL, Chen LH, Barile E, Emdadi A, Sabet M, Yuan H, Wei J, Guiney D, Pellecchia M. Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors. Bioorg Med Chem. 2009 May 01; 17(9):3352-68. PMID: 19359184; PMCID: PMC2730741.
    16. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney D, Webster NJ, Broide DH, Ryan AF, Wasserman SI. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. PMID: 18986247; PMCID: PMC3584630.
    17. van Sorge NM, Ebrahimi CM, McGillivray SM, Quach D, Sabet M, Guiney D, Doran KS. Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis. PLoS One. 2008 Aug 13; 3(8):e2964. PMID: 18698416; PMCID: PMC2493037.
    18. Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney D, Corr M. In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol. 2008 Feb; 251(2):78-85. PMID: 18495099; PMCID: PMC4012540.
    19. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2008 May; 28(5):724. PMID: 18504811.
      View in: PubMed
    20. Le Negrate G, Faustin B, Welsh K, Loeffler M, Krajewska M, Hasegawa P, Mukherjee S, Orth K, Krajewski S, Godzik A, Guiney D, Reed JC. Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses. J Immunol. 2008 Apr 01; 180(7):5045-56. PMID: 18354230.
      View in: PubMed
    21. Woo H, Okamoto S, Guiney D, Gunn JS, Fierer J. A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice. PLoS One. 2008 Feb 13; 3(2):e1603. PMID: 18270590; PMCID: PMC2225501.
    22. Browne SH, Hasegawa P, Okamoto S, Fierer J, Guiney D. Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice. FEMS Immunol Med Microbiol. 2008 Mar; 52(2):194-201. PMID: 18248436.
      View in: PubMed
    23. Johnson SL, Chen LH, Harbach R, Sabet M, Savinov A, Cotton NJ, Strongin A, Guiney D, Pellecchia M. Rhodanine derivatives as selective protease inhibitors against bacterial toxins. Chem Biol Drug Des. 2008 Feb; 71(2):131-9. PMID: 18221310.
      View in: PubMed
    24. Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, David M, Fierer J, Guiney D, Rickert RC. Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS One. 2007 Oct 17; 2(10):e1044. PMID: 17940608; PMCID: PMC2001179.
    25. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney D, Lebl M, Strongin AY. Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20; 282(29):20847-53. PMID: 17537721.
      View in: PubMed
    26. Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney D. Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. Infect Immun. 2007 May; 75(5):2408-14. PMID: 17353291; PMCID: PMC1865764.
    27. Obonyo M, Cole SP, Datta SK, Guiney D. Evidence for interleukin-1-independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori-infected murine dendritic cells deficient in the interleukin-1 receptor. FEMS Immunol Med Microbiol. 2006 Aug; 47(3):414-9. PMID: 16872378.
      View in: PubMed
    28. Sabet M, Cottam HB, Guiney D. Modulation of cytokine production and enhancement of cell viability by TLR7 and TLR9 ligands during anthrax infection of macrophages. FEMS Immunol Med Microbiol. 2006 Aug; 47(3):369-79. PMID: 16872373.
      View in: PubMed
    29. Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney D, Fierer J, Raz E. Vaccination with irradiated Listeria induces protective T cell immunity. Immunity. 2006 Jul; 25(1):143-52. PMID: 16860763.
      View in: PubMed
    30. Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity. 2006 Apr; 24(4):475-87. PMID: 16618605.
      View in: PubMed
    31. Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney D. CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages. FEMS Immunol Med Microbiol. 2005 Aug 01; 45(2):303-10. PMID: 16002269.
      View in: PubMed
    32. Valle E, Guiney D. Characterization of Salmonella-induced cell death in human macrophage-like THP-1 cells. Infect Immun. 2005 May; 73(5):2835-40. PMID: 15845488; PMCID: PMC1087321.
    33. Guiney D, Lesnick M. Targeting of the actin cytoskeleton during infection by Salmonella strains. Clin Immunol. 2005 Mar; 114(3):248-55. PMID: 15721835.
      View in: PubMed
    34. Guiney D. The role of host cell death in Salmonella infections. Curr Top Microbiol Immunol. 2005; 289:131-50. PMID: 15791954.
      View in: PubMed
    35. Schaffner A, King CC, Schaer D, Guiney D. Induction and antimicrobial activity of platelet basic protein derivatives in human monocytes. J Leukoc Biol. 2004 Nov; 76(5):1010-8. PMID: 15316029.
      View in: PubMed
    36. Cole SP, Harwood J, Lee R, She R, Guiney D. Characterization of monospecies biofilm formation by Helicobacter pylori. J Bacteriol. 2004 May; 186(10):3124-32. PMID: 15126474; PMCID: PMC400600.
    37. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney D, Karin M. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5. PMID: 15029200.
      View in: PubMed
    38. Wang JP, Rought SE, Corbeil J, Guiney D. Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection. FEMS Immunol Med Microbiol. 2003 Nov 28; 39(2):163-72. PMID: 14625100.
      View in: PubMed
    39. Guiney D, Hasegawa P, Cole SP. Helicobacter pylori preferentially induces interleukin 12 (IL-12) rather than IL-6 or IL-10 in human dendritic cells. Infect Immun. 2003 Jul; 71(7):4163-6. PMID: 12819109; PMCID: PMC161996.
    40. Obonyo M, Guiney D, Fierer J, Cole SP. Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection. Helicobacter. 2003; 8(5):495-502. PMID: 14535996.
      View in: PubMed
    41. Browne SH, Lesnick ML, Guiney D. Genetic requirements for salmonella-induced cytopathology in human monocyte-derived macrophages. Infect Immun. 2002 Dec; 70(12):7126-35. PMID: 12438395; PMCID: PMC133012.
    42. Paesold G, Guiney D, Eckmann L, Kagnoff MF. Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella-induced apoptosis in intestinal epithelial cells. Cell Microbiol. 2002 Nov; 4(11):771-81. PMID: 12427099.
      View in: PubMed
    43. Sly LM, Guiney D, Reiner NE. Salmonella enterica serovar Typhimurium periplasmic superoxide dismutases SodCI and SodCII are required for protection against the phagocyte oxidative burst. Infect Immun. 2002 Sep; 70(9):5312-5. PMID: 12183590; PMCID: PMC128279.
    44. Libby SJ, Lesnick M, Hasegawa P, Kurth M, Belcher C, Fierer J, Guiney D. Characterization of the spv locus in Salmonella enterica serovar Arizona. Infect Immun. 2002 Jun; 70(6):3290-4. PMID: 12011028; PMCID: PMC127997.
    45. Obonyo M, Guiney D, Harwood J, Fierer J, Cole SP. Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection. Infect Immun. 2002 Jun; 70(6):3295-9. PMID: 12011029; PMCID: PMC127973.
    46. Guiney D. Regulation of bacterial virulence gene expression by the host environment. J Clin Invest. 1997 Feb 15; 99(4):565-9. PMID: 9045855; PMCID: PMC507835.