Loading...

Hiroshi Kiyono

Title(s)Adjunct Professor, Medicine
SchoolHealth Sciences
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Takahashi I, Hosomi K, Nagatake T, Tobou H, Yamamoto D, Hayashi I, Kurashima Y, Sato S, Shibata N, Goto Y, Maruyama F, Nakagawa I, Kuwae A, Abe A, Kunisawa J, Kiyono H. Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. Int Immunol. 2019 Oct 20. PMID: 31630178.
      View in: PubMed
    2. Joo S, Suwanto A, Sato A, Nakahashi-Ouchida R, Mori H, Uchida Y, Sato S, Kurashima Y, Yuki Y, Fujihashi K, Kawaguchi Y, Kiyono H. A role for the CCR5-CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization. Mucosal Immunol. 2019 Sep 24. PMID: 31551493.
      View in: PubMed
    3. Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M. Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. Immunity. 2019 Sep 17; 51(3):508-521.e6. PMID: 31471109.
      View in: PubMed
    4. Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S. Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases. Gastroenterology. 2019 Aug 21. PMID: 31445037.
      View in: PubMed
    5. Hashizume-Takizawa T, Shibata N, Kurashima Y, Kiyono H, Kurita-Ochiai T, Fujihashi K. Distinct roles for Peyer's patch B cells for induction of antigen-specific IgA antibody responses in mice administered oral recombinant Salmonella. Int Immunol. 2019 Jul 30; 31(8):531-541. PMID: 30868152.
      View in: PubMed
    6. Nishida K, Hasegawa A, Yamasaki S, Uchida R, Ohashi W, Kurashima Y, Kunisawa J, Kimura S, Iwanaga T, Watarai H, Hase K, Ogura H, Nakayama M, Kashiwakura JI, Okayama Y, Kubo M, Ohara O, Kiyono H, Koseki H, Murakami M, Hirano T. Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis. Sci Rep. 2019 Jul 25; 9(1):10842. PMID: 31346193.
      View in: PubMed
    7. Kurashima Y, Tokuhara D, Kamioka M, Inagaki Y, Kiyono H. Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells. Front Immunol. 2019; 10:1281. PMID: 31275305.
      View in: PubMed
    8. Hosomi K, Kiyono H, Kunisawa J. Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases. Gut Microbes. 2019 May 23; 1-9. PMID: 31120334.
      View in: PubMed
    9. Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H. Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation. J Allergy Clin Immunol. 2019 Sep; 144(3):698-709.e9. PMID: 31125592.
      View in: PubMed
    10. Tiwari P, Nagatake T, Hirata SI, Sawane K, Saika A, Shibata Y, Morimoto S, Honda T, Adachi J, Abe Y, Isoyama J, Tomonaga T, Kiyono H, Kabashima K, Kunisawa J. Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice. Allergy. 2019 Aug; 74(8):1522-1532. PMID: 30843234.
      View in: PubMed
    11. Tokuhara D, Kiyono H. [MUCOSAL MULTI-ECOSYSTEM FOR THE PREVENTION AND TREATMENT OF MUCOSAL DISORDERS]. Arerugi. 2019; 68(6):675-680. PMID: 31308333.
      View in: PubMed
    12. Kiyono H, Izuhara K. New trends in mucosal immunology and allergy. Allergol Int. 2019 Jan; 68(1):1-3. PMID: 30591151.
      View in: PubMed
    13. Yoshihara S, Kiyono H. [THE MUCOSAL IMMUNE SYSTEM LEADS TO THE DEVELOPMENT OF NOVEL STRATEGY FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES]. Arerugi. 2019; 68(8):933-941. PMID: 31534104.
      View in: PubMed
    14. Sato S, Hisaie K, Kurokawa S, Suzuki A, Sakon N, Uchida Y, Yuki Y, Kiyono H. Human Norovirus Propagation in Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells. Cell Mol Gastroenterol Hepatol. 2019; 7(3):686-688.e5. PMID: 30543870.
      View in: PubMed
    15. Tokuhara D, Kurashima Y, Kamioka M, Nakayama T, Ernst P, Kiyono H. A comprehensive understanding of the gut mucosal immune system in allergic inflammation. Allergol Int. 2019 Jan; 68(1):17-25. PMID: 30366757.
      View in: PubMed
    16. Tada R, Yamanaka D, Ogasawara M, Saito M, Ohno N, Kiyono H, Kunisawa J, Aramaki Y. Polymeric Caffeic Acid Is a Safer Mucosal Adjuvant That Augments Antigen-Specific Mucosal and Systemic Immune Responses in Mice. Mol Pharm. 2018 09 04; 15(9):4226-4234. PMID: 30107747.
      View in: PubMed
    17. Inami A, Kiyono H, Kurashima Y. ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract. Int J Mol Sci. 2018 Aug 12; 19(8). PMID: 30103545.
      View in: PubMed
    18. Nakahashi-Ouchida R, Yuki Y, Kiyono H. Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases. Hum Vaccin Immunother. 2018; 14(9):2189-2193. PMID: 29624474.
      View in: PubMed
    19. Tada R, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y. Intranasal administration of cationic liposomes enhanced granulocyte-macrophage colony-stimulating factor expression and this expression is dispensable for mucosal adjuvant activity. BMC Res Notes. 2018 Jul 13; 11(1):472. PMID: 30005702.
      View in: PubMed
    20. Tada R, Suzuki H, Takahashi S, Negishi Y, Kiyono H, Kunisawa J, Aramaki Y. Nasal vaccination with pneumococcal surface protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice. Int Immunopharmacol. 2018 Aug; 61:385-393. PMID: 29945026.
      View in: PubMed
    21. Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing. Int Immunol. 2018 04 03; 30(4):141-154. PMID: 29617862.
      View in: PubMed
    22. Hirukawa S, Sagara H, Kaneto S, Kondo T, Kiga K, Sanada T, Kiyono H, Mimuro H. Characterization of morphological conversion of Helicobacter pylori under anaerobic conditions. Microbiol Immunol. 2018 Apr; 62(4):221-228. PMID: 29446491.
      View in: PubMed
    23. Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Sci Transl Med. 2018 02 21; 10(429). PMID: 29467297.
      View in: PubMed
    24. Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J. Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. Sci Rep. 2018 02 13; 8(1):2904. PMID: 29440671.
      View in: PubMed
    25. Shibata N, Kunisawa J, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K, Kiyono H. Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity. Mucosal Immunol. 2018 05; 11(3):693-702. PMID: 29411777.
      View in: PubMed
    26. Azegami T, Yuki Y, Hayashi K, Hishikawa A, Sawada SI, Ishige K, Akiyoshi K, Kiyono H, Itoh H. Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents. J Hypertens. 2018 02; 36(2):387-394. PMID: 28832363.
      View in: PubMed
    27. Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2018 08; 142(2):470-484.e12. PMID: 29288079.
      View in: PubMed
    28. Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H. Development of immune and microbial environments is independently regulated in the mammary gland. Mucosal Immunol. 2018 05; 11(3):643-653. PMID: 29346344.
      View in: PubMed
    29. Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H. Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System. Front Immunol. 2017; 8:1787. PMID: 29321781.
      View in: PubMed
    30. Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H. A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. Stem Cell Reports. 2018 01 09; 10(1):314-328. PMID: 29233552.
      View in: PubMed
    31. Shibata N, Kunisawa J, Kiyono H. Dietary and Microbial Metabolites in the Regulation of Host Immunity. Front Microbiol. 2017; 8:2171. PMID: 29163449.
      View in: PubMed
    32. Azegami T, Yuki Y, Nakahashi R, Itoh H, Kiyono H. Nanogel-based nasal vaccines for infectious and lifestyle-related diseases. Mol Immunol. 2018 06; 98:19-24. PMID: 29096936.
      View in: PubMed
    33. Nakahashi-Ouchida R, Yuki Y, Kiyono H. Development of a nanogel-based nasal vaccine as a novel antigen delivery system. Expert Rev Vaccines. 2017 12; 16(12):1231-1240. PMID: 29053938.
      View in: PubMed
    34. Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. J Clin Invest. 2017 Oct 02; 127(10):3784-3795. PMID: 28891812.
      View in: PubMed
    35. Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. IL-22 induces Reg3? and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017 Oct 02; 214(10):3037-3050. PMID: 28811323.
      View in: PubMed
    36. Takahashi Y, Sato S, Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T, Kiyono H. Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells. EBioMedicine. 2017 Sep; 23:34-45. PMID: 28789943.
      View in: PubMed
    37. Ogawa T, Kashima K, Yuki Y, Mejima M, Kurokawa S, Kuroda M, Okazawa A, Kiyono H, Ohta D. Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit. Sci Rep. 2017 07 12; 7(1):5196. PMID: 28701756.
      View in: PubMed
    38. Kim SH, Cho BH, Kiyono H, Jang YS. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches. Sci Rep. 2017 06 21; 7(1):3980. PMID: 28638068.
      View in: PubMed
    39. Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H. Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Immunity. 2017 05 16; 46(5):863-874.e4. PMID: 28514691.
      View in: PubMed
    40. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med. 2017 06 05; 214(6):1607-1618. PMID: 28512157.
      View in: PubMed
    41. Park EJ, Shimaoka M, Kiyono H. MicroRNA-mediated dynamic control of mucosal immunity. Int Immunol. 2017 04 01; 29(4):157-163. PMID: 28383678.
      View in: PubMed
    42. Nakajima-Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, Murakami H, Hosono A, Nochi T, Wakatsuki Y, Shimojo N, Kaminogawa S, Sato R, Kiyono H, Hachimura S. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy. PLoS One. 2017; 12(2):e0172795. PMID: 28234975.
      View in: PubMed
    43. Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One. 2017; 12(2):e0172509. PMID: 28225814.
      View in: PubMed
    44. Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H. Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nat Commun. 2017 02 22; 8:14509. PMID: 28224999.
      View in: PubMed
    45. Tada R, Muto S, Iwata T, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y. Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice. BMC Res Notes. 2017 Jan 26; 10(1):68. PMID: 28126014.
      View in: PubMed
    46. Azegami T, Yuki Y, Sawada S, Mejima M, Ishige K, Akiyoshi K, Itoh H, Kiyono H. Nanogel-based nasal ghrelin vaccine prevents obesity. Mucosal Immunol. 2017 09; 10(5):1351-1360. PMID: 28120848.
      View in: PubMed
    47. Kurashima Y, Kiyono H. Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. Annu Rev Immunol. 2017 04 26; 35:119-147. PMID: 28125357.
      View in: PubMed
    48. Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R. The spleen is the site where mast cells are induced in the development of food allergy. Int Immunol. 2017 01 01; 29(1):31-45. PMID: 28177443.
      View in: PubMed
    49. Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF, Kiyono H. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunol. 2017 07; 10(4):901-911. PMID: 27924821.
      View in: PubMed
    50. Nelson S, Kiyono H, Kurashima Y. Epithelial extracellular ATP: an initiator of immunity to parasitic infections. Immunol Cell Biol. 2017 02; 95(2):117-118. PMID: 27874014.
      View in: PubMed
    51. Goto Y, Uematsu S, Kiyono H. Epithelial glycosylation in gut homeostasis and inflammation. Nat Immunol. 2016 Oct 19; 17(11):1244-1251. PMID: 27760104.
      View in: PubMed
    52. Lee J, Park EJ, Kiyono H. MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation. BMB Rep. 2016 May; 49(5):263-9. PMID: 26923304.
      View in: PubMed
    53. Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF. Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism. Immunity. 2016 Mar 15; 44(3):634-646. PMID: 26982365.
      View in: PubMed
    54. Kogure Y, Kurashima Y, Kiyono H. [MAST CELL MEDIATED HOMEOSTATIC AND BARRIER SYSTEM]. Arerugi. 2016 Mar; 65(2):104-12. PMID: 27086955.
      View in: PubMed
    55. Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H. Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. Regul Toxicol Pharmacol. 2016 Apr; 76:128-36. PMID: 26851506.
      View in: PubMed
    56. Kunisawa J, Kiyono H. Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy. Front Nutr. 2016; 3:3. PMID: 26858949.
      View in: PubMed
    57. Saito S, Ainai A, Suzuki T, Harada N, Ami Y, Yuki Y, Takeyama H, Kiyono H, Tsukada H, Hasegawa H. The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine. Vaccine. 2016 Feb 24; 34(9):1201-7. PMID: 26802605.
      View in: PubMed
    58. Kashima K, Yuki Y, Mejima M, Kurokawa S, Suzuki Y, Minakawa S, Takeyama N, Fukuyama Y, Azegami T, Tanimoto T, Kuroda M, Tamura M, Gomi Y, Kiyono H. Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants. Plant Cell Rep. 2016 Mar; 35(3):667-79. PMID: 26661780.
      View in: PubMed
    59. Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis. Sci Rep. 2015 Dec 09; 5:18174. PMID: 26647826.
      View in: PubMed
    60. Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages. PLoS One. 2015; 10(11):e0142920. PMID: 26575399.
      View in: PubMed
    61. Goto Y, Lamichhane A, Kamioka M, Sato S, Honda K, Kunisawa J, Kiyono H. IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut. Sci Rep. 2015 Nov 02; 5:15918. PMID: 26522513.
      View in: PubMed
    62. Tada R, Hidaka A, Iwase N, Takahashi S, Yamakita Y, Iwata T, Muto S, Sato E, Takayama N, Honjo E, Kiyono H, Kunisawa J, Aramaki Y. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice. PLoS One. 2015; 10(10):e0139785. PMID: 26440657.
      View in: PubMed
    63. Goto Y, Kurashima Y, Kiyono H. [Roles of the gut mucosal immune system in symbiosis and immunity]. Rinsho Ketsueki. 2015 Oct; 56(10):2205-12. PMID: 26458461.
      View in: PubMed
    64. Fukuyama Y, Okada K, Yamaguchi M, Kiyono H, Mori K, Yuki Y. Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice. PLoS One. 2015; 10(9):e0139368. PMID: 26422280.
      View in: PubMed
    65. Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M, Kiyono H. Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1. Cell Rep. 2015 Oct 06; 13(1):122-131. PMID: 26411688.
      View in: PubMed
    66. Takeyama N, Kiyono H, Yuki Y. Plant-based vaccines for animals and humans: recent advances in technology and clinical trials. Ther Adv Vaccines. 2015 Sep; 3(5-6):139-54. PMID: 26668752.
      View in: PubMed
    67. Takeyama N, Yuki Y, Tokuhara D, Oroku K, Mejima M, Kurokawa S, Kuroda M, Kodama T, Nagai S, Ueda S, Kiyono H. Oral rice-based vaccine induces passive and active immunity against enterotoxigenic E. coli-mediated diarrhea in pigs. Vaccine. 2015 Sep 22; 33(39):5204-11. PMID: 26254309.
      View in: PubMed
    68. Park EJ, Yuki Y, Kiyono H, Shimaoka M. Structural basis of blocking integrin activation and deactivation for anti-inflammation. J Biomed Sci. 2015 Jul 08; 22:51. PMID: 26152212.
      View in: PubMed
    69. Goto Y, Kurashima Y, Kiyono H. The gut microbiota and inflammatory bowel disease. Curr Opin Rheumatol. 2015 Jul; 27(4):388-96. PMID: 26002031.
      View in: PubMed
    70. Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. Dietary ?3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep. 2015 Jun 11; 5:9750. PMID: 26065911.
      View in: PubMed
    71. Suzuki H, Watari A, Hashimoto E, Yonemitsu M, Kiyono H, Yagi K, Kondoh M, Kunisawa J. C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine. PLoS One. 2015; 10(5):e0126352. PMID: 26018248.
      View in: PubMed
    72. Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H. Central Role of Core Binding Factor ß2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. PLoS One. 2015; 10(5):e0127460. PMID: 26001080.
      View in: PubMed
    73. Kurashima Y, Kiyono H, Kunisawa J. Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation. Mediators Inflamm. 2015; 2015:427125. PMID: 25944982.
      View in: PubMed
    74. Kishida K, Kohyama M, Kurashima Y, Kogure Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H. Negative regulation of DSS-induced experimental colitis by PILRa. Int Immunol. 2015 Jun; 27(6):307-14. PMID: 25710489.
      View in: PubMed
    75. Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K. The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015 Feb 17; 42(2):279-293. PMID: 25692702.
      View in: PubMed
    76. Fukuyama Y, Yuki Y, Katakai Y, Harada N, Takahashi H, Takeda S, Mejima M, Joo S, Kurokawa S, Sawada S, Shibata H, Park EJ, Fujihashi K, Briles DE, Yasutomi Y, Tsukada H, Akiyoshi K, Kiyono H. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunol. 2015 Sep; 8(5):1144-53. PMID: 25669148.
      View in: PubMed
    77. Kashima K, Mejima M, Kurokawa S, Kuroda M, Kiyono H, Yuki Y. Comparative whole-genome analyses of selection marker-free rice-based cholera toxin B-subunit vaccine lines and wild-type lines. BMC Genomics. 2015 Feb 05; 16:48. PMID: 25653106.
      View in: PubMed
    78. Kunisawa J, Kiyono H. Vitamins mediate immunological homeostasis and diseases at the surface of the body. Endocr Metab Immune Disord Drug Targets. 2015; 15(1):25-30. PMID: 25335990.
      View in: PubMed
    79. Kiyono H, Azegami T. The mucosal immune system: From dentistry to vaccine development. Proc Jpn Acad Ser B Phys Biol Sci. 2015; 91(8):423-39. PMID: 26460320.
      View in: PubMed
    80. Sato S, Kiyono H, Fujihashi K. Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review. Gerontology. 2015; 61(4):336-42. PMID: 25531743.
      View in: PubMed
    81. Kurashima Y, Kiyono H, Kunisawa J. [Purinergic signaling mediates mast cell activation in intestinal inflammation]. Seikagaku. 2014 Dec; 86(6):798-802. PMID: 25675821.
      View in: PubMed
    82. Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K. Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease. J Immunol. 2015 Jan 01; 194(1):398-406. PMID: 25422510.
      View in: PubMed
    83. Nakajima-Adachi H, Kikuchi A, Fujimura Y, Shibahara K, Makino T, Goseki-Sone M, Kihara-Fujioka M, Nochi T, Kurashima Y, Igarashi O, Yamamoto M, Kunisawa J, Toda M, Kaminogawa S, Sato R, Kiyono H, Hachimura S. Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy. PLoS One. 2014; 9(10):e107492. PMID: 25290461.
      View in: PubMed
    84. Okura H, Sato S, Kishikawa S, Kaneto S, Nakashima T, Yoshida N, Takayanagi H, Kiyono H. Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. PLoS One. 2014; 9(9):e108294. PMID: 25244033.
      View in: PubMed
    85. Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H. Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol. 2014 Dec; 88(23):13699-708. PMID: 25231301.
      View in: PubMed
    86. Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science. 2014 Sep 12; 345(6202):1254009. PMID: 25214634.
      View in: PubMed
    87. Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H. Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. J Immunol. 2014 Aug 15; 193(4):1666-71. PMID: 25031459.
      View in: PubMed
    88. Azegami T, Itoh H, Kiyono H, Yuki Y. Novel transgenic rice-based vaccines. Arch Immunol Ther Exp (Warsz). 2015 Apr; 63(2):87-99. PMID: 25027548.
      View in: PubMed
    89. Azegami T, Yuki Y, Kiyono H. Challenges in mucosal vaccines for the control of infectious diseases. Int Immunol. 2014 Sep; 26(9):517-28. PMID: 24914172.
      View in: PubMed
    90. Tokuhara D, Nochi T, Matsumura A, Mejima M, Takahashi Y, Kurokawa S, Kiyono H, Yuki Y. Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine. Dig Dis Sci. 2014 Nov; 59(11):2682-92. PMID: 24838500.
      View in: PubMed
    91. Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T. Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice. Inflamm Bowel Dis. 2014 May; 20(5):790-9. PMID: 24651581.
      View in: PubMed
    92. Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 2014 Apr 10; 5:3704. PMID: 24718324.
      View in: PubMed
    93. Kurashima Y, Amiya T, Fujisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. Immunity. 2014 Apr 17; 40(4):530-41. PMID: 24726878.
      View in: PubMed
    94. Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 2014 Mar 18; 5:3492. PMID: 24637670.
      View in: PubMed
    95. Kotani Y, Kunisawa J, Suzuki Y, Sato I, Saito T, Toba M, Kohda N, Kiyono H. Role of Lactobacillus pentosus Strain b240 and the Toll-like receptor 2 axis in Peyer's patch dendritic cell-mediated immunoglobulin A enhancement. PLoS One. 2014; 9(3):e91857. PMID: 24632732.
      View in: PubMed
    96. Kurashima Y, Kiyono H. New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development. Exp Mol Med. 2014 Mar 14; 46:e83. PMID: 24626169.
      View in: PubMed
    97. Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H. A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. J Biotechnol. 2014 Apr 10; 175:45-52. PMID: 24548461.
      View in: PubMed
    98. Fujihashi K, Sato S, Kiyono H. Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. Exp Gerontol. 2014 Jun; 54:21-6. PMID: 24440991.
      View in: PubMed
    99. Suzuki H, Kondoh M, Yagi K, Kiyono H, Kunisawa J. [The development of mucosal vaccine using bacterial function for targeting mucosal tissues]. Yakugaku Zasshi. 2014; 134(5):629-34. PMID: 24790045.
      View in: PubMed
    100. Korneychuk N, Ramiro-Puig E, Ettersperger J, Schulthess J, Montcuquet N, Kiyono H, Meresse B, Cerf-Bensussan N. Interleukin 15 and CD4? T cells cooperate to promote small intestinal enteropathy in response to dietary antigen. Gastroenterology. 2014 Apr; 146(4):1017-27. PMID: 24361466.
      View in: PubMed
    101. Lamichhane A, Kiyono H, Kunisawa J. Nutritional components regulate the gut immune system and its association with intestinal immune disease development. J Gastroenterol Hepatol. 2013 Dec; 28 Suppl 4:18-24. PMID: 24251698.
      View in: PubMed
    102. Kurashima Y, Goto Y, Kiyono H. Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur J Immunol. 2013 Dec; 43(12):3108-15. PMID: 24414823.
      View in: PubMed
    103. Kishino S, Takeuchi M, Park SB, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17808-13. PMID: 24127592.
      View in: PubMed
    104. Kurokawa S, Kuroda M, Mejima M, Nakamura R, Takahashi Y, Sagara H, Takeyama N, Satoh S, Kiyono H, Teshima R, Masumura T, Yuki Y. RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds. Plant Cell Rep. 2014 Jan; 33(1):75-87. PMID: 24085308.
      View in: PubMed
    105. Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. PLoS One. 2013; 8(8):e72050. PMID: 23951282.
      View in: PubMed
    106. Tokuhara D, Álvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, Kuroda M, Oyama M, Kozuka-Hata H, Nochi T, Sagara H, Aladin F, Marcotte H, Frenken LG, Iturriza-Gómara M, Kiyono H, Hammarström L, Yuki Y. Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest. 2013 Sep; 123(9):3829-38. PMID: 23925294.
      View in: PubMed
    107. Kunisawa J, Kiyono H. Vitamin-mediated regulation of intestinal immunity. Front Immunol. 2013; 4:189. PMID: 23874335.
      View in: PubMed
    108. Kurokawa S, Nakamura R, Mejima M, Kozuka-Hata H, Kuroda M, Takeyama N, Oyama M, Satoh S, Kiyono H, Masumura T, Teshima R, Yuki Y. MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of a-amylase/trypsin inhibitor-like protein family as major rice allergens. J Proteome Res. 2013 Jul 05; 12(7):3372-82. PMID: 23763241.
      View in: PubMed
    109. Obata T, Shibata N, Goto Y, Ishikawa I, Sato S, Kunisawa J, Kiyono H. Critical role of dendritic cells in T cell retention in the interfollicular region of Peyer's patches. J Immunol. 2013 Jul 15; 191(2):942-8. PMID: 23772027.
      View in: PubMed
    110. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Takahashi Y, Tokuhara D, Nochi T, Katakai Y, Kuroda M, Takeyama N, Kashima K, Abe M, Chen Y, Nakanishi U, Masumura T, Takeuchi Y, Kozuka-Hata H, Shibata H, Oyama M, Tanaka K, Kiyono H. Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol J. 2013 Sep; 11(7):799-808. PMID: 23601492.
      View in: PubMed
    111. Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert RS, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee JR, Fujihashi K. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One. 2013; 8(4):e60453. PMID: 23565250.
      View in: PubMed
    112. Kong IG, Sato A, Yuki Y, Nochi T, Takahashi H, Sawada S, Mejima M, Kurokawa S, Okada K, Sato S, Briles DE, Kunisawa J, Inoue Y, Yamamoto M, Akiyoshi K, Kiyono H. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun. 2013 May; 81(5):1625-34. PMID: 23460513.
      View in: PubMed
    113. Kunisawa J, Gohda M, Hashimoto E, Ishikawa I, Higuchi M, Suzuki Y, Goto Y, Panea C, Ivanov II, Sumiya R, Aayam L, Wake T, Tajiri S, Kurashima Y, Shikata S, Akira S, Takeda K, Kiyono H. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun. 2013; 4:1772. PMID: 23612313.
      View in: PubMed
    114. Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun. 2013; 4:1949. PMID: 23752491.
      View in: PubMed
    115. Yuki Y, Nochi T, Kong IG, Takahashi H, Sawada S, Akiyoshi K, Kiyono H. Nanogel-based antigen-delivery system for nasal vaccines. Biotechnol Genet Eng Rev. 2013; 29:61-72. PMID: 24568253.
      View in: PubMed
    116. Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K. Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol. 2013 Jan 15; 190(2):774-83. PMID: 23241884.
      View in: PubMed
    117. Sato S, Kaneto S, Shibata N, Takahashi Y, Okura H, Yuki Y, Kunisawa J, Kiyono H. Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells. Mucosal Immunol. 2013 Jul; 6(4):838-46. PMID: 23212199.
      View in: PubMed
    118. Nakajima-Adachi H, Koike E, Totsuka M, Hiraide E, Wakatsuki Y, Kiyono H, Hachimura S. Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4?T cells into the Th2 or Th1 phenotype. Biosci Biotechnol Biochem. 2012; 76(10):1979-81. PMID: 23047087.
      View in: PubMed
    119. Kumagai T, Kiyono H. Summary for symposium I on the development of a more efficacious influenza vaccine held at the 15th Annual Meeting of the Japanese Society for Vaccinology, Tokyo, 2011. Vaccine. 2012 Sep 28; 30(44):6338-9. PMID: 22906723.
      View in: PubMed
    120. Kunisawa J, Kiyono H. Immune regulation and monitoring at the epithelial surface of the intestine. Drug Discov Today. 2013 Jan; 18(1-2):87-92. PMID: 22897879.
      View in: PubMed
    121. Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K. Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol. 2012 Sep 15; 189(6):2869-78. PMID: 22869901.
      View in: PubMed
    122. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K. PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 2012 Oct; 24(10):613-23. PMID: 22836022.
      View in: PubMed
    123. Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 2012 Jun 08; 336(6086):1321-5. PMID: 22674331.
      View in: PubMed
    124. Jeon SG, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, Tsuji NM, Kiyono H, Ma JS, Kusu T, Okumura R, Hara H, Yoshida H, Yamamoto M, Nomoto K, Takeda K. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog. 2012; 8(5):e1002714. PMID: 22693446.
      View in: PubMed
    125. Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice. J Immunol. 2012 Jun 15; 188(12):6145-55. PMID: 22611244.
      View in: PubMed
    126. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Kong IG, Kuroda M, Takahashi Y, Nochi T, Tokuhara D, Kohda T, Kozaki S, Kiyono H. RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine. Vaccine. 2012 Jun 13; 30(28):4160-6. PMID: 22554467.
      View in: PubMed
    127. Sato S, Kiyono H. The mucosal immune system of the respiratory tract. Curr Opin Virol. 2012 Jun; 2(3):225-32. PMID: 22542216.
      View in: PubMed
    128. Kunisawa J, Kiyono H. Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses. Front Immunol. 2012; 3:65. PMID: 22566946.
      View in: PubMed
    129. Kunisawa J, Kiyono H. Immunological function of sphingosine 1-phosphate in the intestine. Nutrients. 2012 03; 4(3):154-66. PMID: 22666543.
      View in: PubMed
    130. Fujkuyama Y, Tokuhara D, Kataoka K, Gilbert RS, McGhee JR, Yuki Y, Kiyono H, Fujihashi K. Novel vaccine development strategies for inducing mucosal immunity. Expert Rev Vaccines. 2012 Mar; 11(3):367-79. PMID: 22380827.
      View in: PubMed
    131. Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 2012; 7(2):e32094. PMID: 22363800.
      View in: PubMed
    132. Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood. 2012 Mar 22; 119(12):2768-77. PMID: 22279057.
      View in: PubMed
    133. Kim DY, Fukuyama S, Nagatake T, Takamura K, Kong IG, Yokota Y, Lee CH, Kiyono H. Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model. Allergy. 2012 Apr; 67(4):502-9. PMID: 22257110.
      View in: PubMed
    134. Goto Y, Kiyono H. Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol Rev. 2012 Jan; 245(1):147-63. PMID: 22168418.
      View in: PubMed
    135. Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun. 2012; 3:1034. PMID: 22948816.
      View in: PubMed
    136. Yamamoto M, Pascual DW, Kiyono H. M cell-targeted mucosal vaccine strategies. Curr Top Microbiol Immunol. 2012; 354:39-52. PMID: 21688209.
      View in: PubMed
    137. Kiyono H, Okada K. [Mucosal immune systems--frontline of the biological defence mechanism]. Nihon Jibiinkoka Gakkai Kaiho. 2011 Nov; 114(11):843-50. PMID: 22295432.
      View in: PubMed
    138. Kim SH, Jung DI, Yang IY, Kim J, Lee KY, Nochi T, Kiyono H, Jang YS. M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery. Eur J Immunol. 2011 Nov; 41(11):3219-29. PMID: 21887786.
      View in: PubMed
    139. Takeyama N, Yuki Y, Kiyono H. [Current progress in the development of mucosal vaccines]. Nihon Rinsho. 2011 Sep; 69(9):1555-60. PMID: 21922752.
      View in: PubMed
    140. Okada K, Yamasoba T, Kiyono H. Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine. Adv Otorhinolaryngol. 2011; 72:31-6. PMID: 21865684.
      View in: PubMed
    141. Stappenbeck T, Kiyono H. Host pathogens. Editorial overview. Curr Opin Immunol. 2011 Aug; 23(4):445-7. PMID: 21856138.
      View in: PubMed
    142. Kunisawa J, Kurashima Y, Kiyono H. Gut-associated lymphoid tissues for the development of oral vaccines. Adv Drug Deliv Rev. 2012 May 01; 64(6):523-30. PMID: 21827802.
      View in: PubMed
    143. Burggraf M, Nakajima-Adachi H, Hachimura S, Ilchmann A, Pemberton AD, Kiyono H, Vieths S, Toda M. Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy. Mol Nutr Food Res. 2011 Oct; 55(10):1475-83. PMID: 21714123.
      View in: PubMed
    144. Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011 May 19; 9(5):376-89. PMID: 21575909.
      View in: PubMed
    145. Goto Y, Kiyono H. Epithelial cell microRNAs in gut immunity. Nat Immunol. 2011 Mar; 12(3):195-7. PMID: 21321589.
      View in: PubMed
    146. Kim DY, Sato A, Fukuyama S, Sagara H, Nagatake T, Kong IG, Goda K, Nochi T, Kunisawa J, Sato S, Yokota Y, Lee CH, Kiyono H. The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J Immunol. 2011 Apr 01; 186(7):4253-62. PMID: 21357262.
      View in: PubMed
    147. Kunisawa J, Kiyono H. Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. Cell Host Microbe. 2011 Feb 17; 9(2):83-4. PMID: 21320688.
      View in: PubMed
    148. Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H. Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun. 2011 Jan 21; 404(3):822-8. PMID: 21172308.
      View in: PubMed
    149. Takahashi I, Fujihashi K, Kiyono H. Mucosal regulatory cells in the gastrointestinal tract and periodontium. Periodontol 2000. 2010 Oct; 54(1):247-56. PMID: 20712644.
      View in: PubMed
    150. Yuki Y, Nochi T, Harada N, Katakai Y, Shibata H, Mejima M, Kohda T, Tokuhara D, Kurokawa S, Takahashi Y, Ono F, Kozaki S, Terao K, Tsukada H, Kiyono H. In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates. J Immunol. 2010 Nov 01; 185(9):5436-43. PMID: 20881188.
      View in: PubMed
    151. Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010 Dec; 84(24):12703-12. PMID: 20881038.
      View in: PubMed
    152. Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K. High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. J Biol Chem. 2010 Oct 01; 285(40):30427-35. PMID: 20663890.
      View in: PubMed
    153. Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H. Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater. 2010 Jul; 9(7):572-8. PMID: 20562880.
      View in: PubMed
    154. Malamut G, El Machhour R, Montcuquet N, Martin-Lannerée S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest. 2010 Jun; 120(6):2131-43. PMID: 20440074.
      View in: PubMed
    155. Kunisawa J, Kiyono H. Aberrant interaction of the gut immune system with environmental factors in the development of food allergies. Curr Allergy Asthma Rep. 2010 May; 10(3):215-21. PMID: 20424996.
      View in: PubMed
    156. Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H. Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8794-9. PMID: 20421480.
      View in: PubMed
    157. Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7419-24. PMID: 20360558.
      View in: PubMed
    158. Fuglem B, Jirillo E, Bjerkås I, Kiyono H, Nochi T, Yuki Y, Raida M, Fischer U, Koppang EO. Antigen-sampling cells in the salmonid intestinal epithelium. Dev Comp Immunol. 2010 Jul; 34(7):768-74. PMID: 20178814.
      View in: PubMed
    159. Umehara T, Udagawa J, Takamura K, Kimura M, Ishimitsu R, Kiyono H, Kawauchi H, Otani H. Role of interleukin-15 in the development of mouse olfactory nerve. Congenit Anom (Kyoto). 2009 Dec; 49(4):253-7. PMID: 20021484.
      View in: PubMed
    160. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 2009 Nov 12; 462(7270):226-30. PMID: 19907495.
      View in: PubMed
    161. Sato A, Kiyono H. [The mucosal immune system: new strategy for the control of allergic diseases]. Nihon Rinsho. 2009 Nov; 67(11):2194-9. PMID: 19899540.
      View in: PubMed
    162. Nochi T, Yuki Y, Katakai Y, Shibata H, Tokuhara D, Mejima M, Kurokawa S, Takahashi Y, Nakanishi U, Ono F, Mimuro H, Sasakawa C, Takaiwa F, Terao K, Kiyono H. A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity. J Immunol. 2009 Nov 15; 183(10):6538-44. PMID: 19880451.
      View in: PubMed
    163. Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR. RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J Immunol. 2009 Nov 01; 183(9):5738-47. PMID: 19828638.
      View in: PubMed
    164. Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 2009 Oct 26; 206(11):2351-64. PMID: 19822644.
      View in: PubMed
    165. Suzuki R, Nourani MR, Saino-Saito S, Abe H, Nochi T, Kiyono H, Spener F, Kondo H, Owada Y. Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine. Histochem Cell Biol. 2009 Dec; 132(6):577-84. PMID: 19787366.
      View in: PubMed
    166. Mavichak R, Takano T, Kondo H, Hirono I, Wada S, Hatai K, Inagawa H, Takahashi Y, Yoshimura T, Kiyono H, Yuki Y, Aoki T. The effect of liposome-coated recombinant protein VP28 against white spot syndrome virus in kuruma shrimp, Marsupenaeus japonicus. J Fish Dis. 2010 Jan; 33(1):69-74. PMID: 19735346.
      View in: PubMed
    167. Yuki Y, Tokuhara D, Nochi T, Yasuda H, Mejima M, Kurokawa S, Takahashi Y, Kataoka N, Nakanishi U, Hagiwara Y, Fujihashi K, Takaiwa F, Kiyono H. Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine. 2009 Oct 09; 27(43):5982-8. PMID: 19665603.
      View in: PubMed
    168. Yuki Y, Kiyono H. Mucosal vaccines: novel advances in technology and delivery. Expert Rev Vaccines. 2009 Aug; 8(8):1083-97. PMID: 19627189.
      View in: PubMed
    169. Fujihashi K, Kiyono H. Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends Immunol. 2009 Jul; 30(7):334-43. PMID: 19540811.
      View in: PubMed
    170. Takahashi I, Nochi T, Yuki Y, Kiyono H. New horizon of mucosal immunity and vaccines. Curr Opin Immunol. 2009 Jun; 21(3):352-8. PMID: 19493665.
      View in: PubMed
    171. Nochi T, Kiyono H. [Recent progress for the development of mucosal vaccine]. Tanpakushitsu Kakusan Koso. 2009 Jun; 54(8 Suppl):1089-95. PMID: 21089546.
      View in: PubMed
    172. Kim D, Kim SH, Park EJ, Kim J, Cho SH, Kagawa J, Arai N, Jun K, Kiyono H, Kim S. Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta. Int Arch Allergy Immunol. 2009; 150(2):164-71. PMID: 19439982.
      View in: PubMed
    173. Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun. 2009 Jun 05; 383(3):340-6. PMID: 19358828.
      View in: PubMed
    174. Kunisawa J, Nochi T, Kiyono H. Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol. 2008 Nov; 29(11):505-13. PMID: 18835748.
      View in: PubMed
    175. Mestecky J, Nguyen H, Czerkinsky C, Kiyono H. Oral immunization: an update. Curr Opin Gastroenterol. 2008 Nov; 24(6):713-9. PMID: 19122521.
      View in: PubMed
    176. Fehervari Z, Kiyono H. The mucosa: at the frontlines of immunity. Trends Immunol. 2008 Nov; 29(11):503-4. PMID: 18838300.
      View in: PubMed
    177. Yuki Y, Kiyono H. [MucoRice: development of rice-based oral vaccine]. Nihon Rinsho Meneki Gakkai Kaishi. 2008 Oct; 31(5):369-74. PMID: 18974620.
      View in: PubMed
    178. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 2008 Jun 15; 180(12):7840-6. PMID: 18523247.
      View in: PubMed
    179. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 2008 Jul; 9(7):769-76. PMID: 18516037.
      View in: PubMed
    180. Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice. Int Immunol. 2008 Jul; 20(7):881-91. PMID: 18492657.
      View in: PubMed
    181. Ooi EL, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol. 2008; 32(10):1211-20. PMID: 18466972.
      View in: PubMed
    182. Caipang CM, Verjan N, Ooi EL, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis. Fish Shellfish Immunol. 2008 Sep; 25(3):315-20. PMID: 18603448.
      View in: PubMed
    183. Verjan N, Ooi EL, Nochi T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2008 Jul; 25(1-2):170-80. PMID: 18499475.
      View in: PubMed
    184. Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol. 2008 Apr 15; 180(8):5335-43. PMID: 18390715.
      View in: PubMed
    185. Momoi F, Hashizume T, Kurita-Ochiai T, Yuki Y, Kiyono H, Yamamoto M. Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies. Infect Immun. 2008 Jun; 76(6):2777-84. PMID: 18411288.
      View in: PubMed
    186. Chang SY, Cha HR, Igarashi O, Rennert PD, Kissenpfennig A, Malissen B, Nanno M, Kiyono H, Kweon MN. Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. J Immunol. 2008 Apr 01; 180(7):4361-5. PMID: 18354155.
      View in: PubMed
    187. Kunisawa J, Gohda M, Kurashima Y, Ishikawa I, Higuchi M, Kiyono H. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. Blood. 2008 May 01; 111(9):4646-52. PMID: 18292290.
      View in: PubMed
    188. Kurashima Y, Kunisawa J, Kiyono H. [Applicable strategies for the mucosal immune system in the regulation of allergic diseases]. Arerugi. 2008 Feb; 57(2):87-94. PMID: 18349582.
      View in: PubMed
    189. Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol. 2008 Feb 01; 180(3):1609-18. PMID: 18209057.
      View in: PubMed
    190. Brandtzaeg P, Kiyono H, Pabst R, Russell MW. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol. 2008 Jan; 1(1):31-7. PMID: 19079158.
      View in: PubMed
    191. Hashizume T, Togawa A, Nochi T, Igarashi O, Kweon MN, Kiyono H, Yamamoto M. Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp. Infect Immun. 2008 Mar; 76(3):927-34. PMID: 18086815.
      View in: PubMed
    192. Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, Kim DY, Fukuyama S, Iwatsuki-Horimoto K, Kawaoka Y, Kohda T, Kozaki S, Igarashi O, Kiyono H. A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med. 2007 Nov 26; 204(12):2789-96. PMID: 17984304.
      View in: PubMed
    193. Takamura K, Fukuyama S, Nagatake T, Kim DY, Kawamura A, Kawauchi H, Kiyono H. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 2007 Nov 01; 179(9):5897-906. PMID: 17947663.
      View in: PubMed
    194. Ooi EL, Verjan N, Hirono I, Nochi T, Kondo H, Aoki T, Kiyono H, Yuki Y. Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli. Fish Shellfish Immunol. 2008 May; 24(5):506-13. PMID: 18329900.
      View in: PubMed
    195. Kunisawa J, Kurashima Y, Higuchi M, Gohda M, Ishikawa I, Ogahara I, Kim N, Shimizu M, Kiyono H. Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med. 2007 Oct 01; 204(10):2335-48. PMID: 17875673.
      View in: PubMed
    196. Kurashima Y, Kunisawa J, Higuchi M, Gohda M, Ishikawa I, Takayama N, Shimizu M, Kiyono H. Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. J Immunol. 2007 Aug 01; 179(3):1577-85. PMID: 17641024.
      View in: PubMed
    197. Yuki Y, Nochi T, Kiyono H. Progress towards an AIDS mucosal vaccine: an overview. Tuberculosis (Edinb). 2007 Aug; 87 Suppl 1:S35-44. PMID: 17652028.
      View in: PubMed
    198. Nochi T, Takagi H, Yuki Y, Yang L, Masumura T, Mejima M, Nakanishi U, Matsumura A, Uozumi A, Hiroi T, Morita S, Tanaka K, Takaiwa F, Kiyono H. Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10986-91. PMID: 17573530.
      View in: PubMed
    199. Ohka S, Igarashi H, Nagata N, Sakai M, Koike S, Nochi T, Kiyono H, Nomoto A. Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. J Virol. 2007 Aug; 81(15):7902-12. PMID: 17507470.
      View in: PubMed
    200. Nagai S, Mimuro H, Yamada T, Baba Y, Moro K, Nochi T, Kiyono H, Suzuki T, Sasakawa C, Koyasu S. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8971-6. PMID: 17502608.
      View in: PubMed
    201. Tamagawa H, Hiroi T, Mizushima T, Ito T, Matsuda H, Kiyono H. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis. Inflamm Bowel Dis. 2007 May; 13(5):547-56. PMID: 17245768.
      View in: PubMed
    202. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007 Apr 15; 178(8):4937-46. PMID: 17404275.
      View in: PubMed
    203. Fukuyama S, Kiyono H. Neuroregulator RET initiates Peyer's-patch tissue genesis. Immunity. 2007 Apr; 26(4):393-5. PMID: 17459808.
      View in: PubMed
    204. Takayama N, Igarashi O, Kweon MN, Kiyono H. Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea. Clin Immunol. 2007 May; 123(2):199-208. PMID: 17360239.
      View in: PubMed
    205. McGhee JR, Kunisawa J, Kiyono H. Gut lymphocyte migration: we are halfway 'home'. Trends Immunol. 2007 Apr; 28(4):150-3. PMID: 17293162.
      View in: PubMed
    206. Kunisawa J, Gohda M, Kiyono H. [Uniqueness of the mucosal immune system for the development of prospective mucosal vaccine]. Yakugaku Zasshi. 2007 Feb; 127(2):319-26. PMID: 17268152.
      View in: PubMed
    207. Kunisawa J, Takahashi I, Kiyono H. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev. 2007 Feb; 215:136-53. PMID: 17291285.
      View in: PubMed
    208. Kunisawa J, Kurashima Y, Gohda M, Higuchi M, Ishikawa I, Miura F, Ogahara I, Kiyono H. Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. Blood. 2007 May 01; 109(9):3749-56. PMID: 17234743.
      View in: PubMed
    209. Kim N, Kunisawa J, Kweon MN, Eog Ji G, Kiyono H. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin Immunol. 2007 Apr; 123(1):30-9. PMID: 17218154.
      View in: PubMed
    210. Tanaka N, Fukuyama S, Fukuiwa T, Kawabata M, Sagara Y, Ito HO, Miwa Y, Nagatake T, Kiyono H, Kurono Y. Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine. 2007 Mar 30; 25(14):2680-7. PMID: 17270319.
      View in: PubMed
    211. Maddaloni M, Staats HF, Mierzejewska D, Hoyt T, Robinson A, Callis G, Kozaki S, Kiyono H, McGhee JR, Fujihashi K, Pascual DW. Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. J Immunol. 2006 Oct 15; 177(8):5524-32. PMID: 17015739.
      View in: PubMed
    212. Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H. Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J Immunol. 2006 Oct 01; 177(7):4276-80. PMID: 16982861.
      View in: PubMed
    213. Hagiwara Y, Kawamura YI, Kataoka K, Rahima B, Jackson RJ, Komase K, Dohi T, Boyaka PN, Takeda Y, Kiyono H, McGhee JR, Fujihashi K. A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking. J Immunol. 2006 Sep 01; 177(5):3045-54. PMID: 16920941.
      View in: PubMed
    214. Duverger A, Jackson RJ, van Ginkel FW, Fischer R, Tafaro A, Leppla SH, Fujihashi K, Kiyono H, McGhee JR, Boyaka PN. Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J Immunol. 2006 Feb 01; 176(3):1776-83. PMID: 16424208.
      View in: PubMed
    215. Jang MH, Sougawa N, Tanaka T, Hirata T, Hiroi T, Tohya K, Guo Z, Umemoto E, Ebisuno Y, Yang BG, Seoh JY, Lipp M, Kiyono H, Miyasaka M. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol. 2006 Jan 15; 176(2):803-10. PMID: 16393963.
      View in: PubMed
    216. Nochi T, Kiyono H. Innate immunity in the mucosal immune system. Curr Pharm Des. 2006; 12(32):4203-13. PMID: 17100623.
      View in: PubMed
    217. Yuki Y, Hara-Yakoyama C, Guadiz AA, Udaka S, Kiyono H, Chatterjee S. Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes. Biotechnol Bioeng. 2005 Dec 30; 92(7):803-9. PMID: 16142801.
      View in: PubMed
    218. Takagi H, Hiroi T, Yang L, Tada Y, Yuki Y, Takamura K, Ishimitsu R, Kawauchi H, Kiyono H, Takaiwa F. A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17525-30. PMID: 16278301.
      View in: PubMed
    219. Kunisawa J, Fukuyama S, Kiyono H. Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Curr Mol Med. 2005 Sep; 5(6):557-72. PMID: 16178767.
      View in: PubMed
    220. Ohmura M, Yamamoto M, Tomiyama-Miyaji C, Yuki Y, Takeda Y, Kiyono H. Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation. Infect Immun. 2005 Jul; 73(7):4088-97. PMID: 15972497.
      View in: PubMed
    221. Hino A, Fukuyama S, Kataoka K, Kweon MN, Fujihashi K, Kiyono H. Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea. J Immunol. 2005 Jun 01; 174(11):7423-32. PMID: 15905591.
      View in: PubMed
    222. Kunisawa J, Kiyono H. A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. Cell Mol Life Sci. 2005 Jun; 62(12):1308-21. PMID: 15971106.
      View in: PubMed
    223. Ueta M, Hamuro J, Kiyono H, Kinoshita S. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005 May 27; 331(1):285-94. PMID: 15845391.
      View in: PubMed
    224. Yamamoto M, Kiyono H. [Host defence mechanisms offered by the mucosal immune system]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:447-53. PMID: 15861694.
      View in: PubMed
    225. Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, Kiyono H. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J Immunol. 2005 Apr 01; 174(7):4365-72. PMID: 15778401.
      View in: PubMed
    226. Nochi T, Kiyono H. [Mucosal immunology]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:14-9. PMID: 15861629.
      View in: PubMed
    227. Kai Y, Takahashi I, Ishikawa H, Hiroi T, Mizushima T, Matsuda C, Kishi D, Hamada H, Tamagawa H, Ito T, Yoshizaki K, Kishimoto T, Matsuda H, Kiyono H. Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells. Gastroenterology. 2005 Apr; 128(4):922-34. PMID: 15825075.
      View in: PubMed
    228. Kobayashi R, Kohda T, Kataoka K, Ihara H, Kozaki S, Pascual DW, Staats HF, Kiyono H, McGhee JR, Fujihashi K. A novel neurotoxoid vaccine prevents mucosal botulism. J Immunol. 2005 Feb 15; 174(4):2190-5. PMID: 15699151.
      View in: PubMed
    229. Nonaka S, Naito T, Chen H, Yamamoto M, Moro K, Kiyono H, Hamada H, Ishikawa H. Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J Immunol. 2005 Feb 15; 174(4):1906-12. PMID: 15699117.
      View in: PubMed
    230. Nochi T, Yuki Y, Terahara K, Hino A, Kunisawa J, Kweon MN, Yamaguchi T, Kiyono H. Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium. Clin Immunol. 2004 Dec; 113(3):326-39. PMID: 15507398.
      View in: PubMed
    231. Yoshino N, Lü FX, Fujihashi K, Hagiwara Y, Kataoka K, Lu D, Hirst L, Honda M, van Ginkel FW, Takeda Y, Miller CJ, Kiyono H, McGhee JR. A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. J Immunol. 2004 Dec 01; 173(11):6850-7. PMID: 15557179.
      View in: PubMed
    232. Ohmura-Hoshino M, Yamamoto M, Yuki Y, Takeda Y, Kiyono H. Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity. Vaccine. 2004 Sep 09; 22(27-28):3751-61. PMID: 15315856.
      View in: PubMed
    233. Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol. 2004 Sep 01; 173(5):3337-47. PMID: 15322197.
      View in: PubMed
    234. Kiyono H, Fukuyama S. NALT- versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol. 2004 Sep; 4(9):699-710. PMID: 15343369.
      View in: PubMed
    235. Yamamoto M, Kweon MN, Rennert PD, Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity. J Immunol. 2004 Jul 15; 173(2):762-9. PMID: 15240662.
      View in: PubMed
    236. Shikina T, Hiroi T, Iwatani K, Jang MH, Fukuyama S, Tamura M, Kubo T, Ishikawa H, Kiyono H. IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J Immunol. 2004 May 15; 172(10):6259-64. PMID: 15128814.
      View in: PubMed
    237. Mizushima T, Ito T, Kishi D, Kai Y, Tamagawa H, Nezu R, Kiyono H, Matsuda H. Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. Inflamm Bowel Dis. 2004 May; 10(3):182-92. PMID: 15290910.
      View in: PubMed
    238. Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K, Sasakawa C, Suzuki T, Nochi T, Yokota Y, Rennert PD, Hiroi T, Tamagawa H, Iijima H, Kunisawa J, Yuki Y, Kiyono H. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6110-5. PMID: 15071180.
      View in: PubMed
    239. Hino A, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea. Am J Pathol. 2004 Apr; 164(4):1327-35. PMID: 15039220.
      View in: PubMed
    240. Kiyono H. [Disease condition and the mechanism of the development of type 2 diabetes mellitus]. Nihon Naika Gakkai Zasshi. 2004 Feb 20; 93 Suppl:48-51. PMID: 15038121.
      View in: PubMed
    241. Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki J, Kiyono H. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. J Immunol. 2003 Oct 15; 171(8):4131-9. PMID: 14530335.
      View in: PubMed
    242. Yuki Y, Kiyono H. New generation of mucosal adjuvants for the induction of protective immunity. Rev Med Virol. 2003 Sep-Oct; 13(5):293-310. PMID: 12931340.
      View in: PubMed
    243. Tamagawa H, Takahashi I, Furuse M, Yoshitake-Kitano Y, Tsukita S, Ito T, Matsuda H, Kiyono H. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab Invest. 2003 Jul; 83(7):1045-53. PMID: 12861044.
      View in: PubMed
    244. Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K, Akira S. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest. 2003 May; 111(9):1297-308. PMID: 12727921.
      View in: PubMed
    245. Jang MH, Kweon MN, Hiroi T, Yamamoto M, Takahashi I, Kiyono H. Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells. Vaccine. 2003 Apr 02; 21(15):1613-9. PMID: 12639482.
      View in: PubMed
    246. Hagiwara Y, McGhee JR, Fujihashi K, Kobayashi R, Yoshino N, Kataoka K, Etani Y, Kweon MN, Tamura S, Kurata T, Takeda Y, Kiyono H, Fujihashi K. Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. J Immunol. 2003 Feb 15; 170(4):1754-62. PMID: 12574339.
      View in: PubMed
    247. Boyaka PN, Ohmura M, Fujihashi K, Koga T, Yamamoto M, Kweon MN, Takeda Y, Jackson RJ, Kiyono H, Yuki Y, McGhee JR. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. J Immunol. 2003 Jan 01; 170(1):454-62. PMID: 12496431.
      View in: PubMed
    248. Okuda Y, Takahashi I, Kim JK, Ohta N, Iwatani K, Iijima H, Kai Y, Tamagawa H, Hiroi T, Kweon MN, Kawano S, Takeda K, Akira S, Sasaki Y, Hori M, Kiyono H. Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells. Am J Pathol. 2003 Jan; 162(1):263-71. PMID: 12507909.
      View in: PubMed
    249. Kweon MN, Kiyono H. Eosinophilic gastroenteritis: a problem of the mucosal immune system? Curr Allergy Asthma Rep. 2003 Jan; 3(1):79-85. PMID: 12542999.
      View in: PubMed
    250. Sakaue G, Hiroi T, Nakagawa Y, Someya K, Iwatani K, Sawa Y, Takahashi H, Honda M, Kunisawa J, Kiyono H. HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. J Immunol. 2003 Jan 01; 170(1):495-502. PMID: 12496436.
      View in: PubMed
    251. Kawahara M, Matsuo K, Nakasone T, Hiroi T, Kiyono H, Matsumoto S, Yamada T, Yamamoto N, Honda M. Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen. Vaccine. 2002 Dec 13; 21(3-4):158-66. PMID: 12450689.
      View in: PubMed
    252. Yuki Y, Kiyono H. [M cells: development and function]. Tanpakushitsu Kakusan Koso. 2002 Dec; 47(16 Suppl):2325-30. PMID: 12518456.
      View in: PubMed
    253. Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, Kiyono H. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. J Immunol. 2002 Dec 01; 169(11):6187-92. PMID: 12444123.
      View in: PubMed
    254. Watanabe I, Hagiwara Y, Kadowaki SE, Yoshikawa T, Komase K, Aizawa C, Kiyono H, Takeda Y, McGhee JR, Chiba J, Sata T, Kurata T, Tamura S. Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K). Vaccine. 2002 Oct 04; 20(29-30):3443-55. PMID: 12297389.
      View in: PubMed
    255. Kweon MN, Yamamoto M, Watanabe F, Tamura S, Van Ginkel FW, Miyauchi A, Takagi H, Takeda Y, Hamabata T, Fujihashi K, McGhee JR, Kiyono H. A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies. J Infect Dis. 2002 Nov 01; 186(9):1261-9. PMID: 12402195.
      View in: PubMed
    256. Yanagita M, Shimabukuro Y, Nozaki T, Yoshimura N, Watanabe J, Koide H, Terakura M, Saho T, Takedachi M, Jang MH, Kiyono H, Murakami S. IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):329-34. PMID: 12237122.
      View in: PubMed
    257. Ueta M, Kweon MN, Sano Y, Sotozono C, Yamada J, Koizumi N, Kiyono H, Kinoshita S. Immunosuppressive properties of human amniotic membrane for mixed lymphocyte reaction. Clin Exp Immunol. 2002 Sep; 129(3):464-70. PMID: 12197887.
      View in: PubMed
    258. Kunisawa J, Takahashi I, Okudaira A, Hiroi T, Katayama K, Ariyama T, Tsutsumi Y, Nakagawa S, Kiyono H, Mayumi T. Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur J Immunol. 2002 Aug; 32(8):2347-55. PMID: 12209648.
      View in: PubMed
    259. Suenobu N, Kweon MN, Kiyono H. Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis. Vaccine. 2002 Jul 26; 20(23-24):2972-80. PMID: 12126910.
      View in: PubMed
    260. Enose Y, Ui M, Miyake A, Suzuki H, Uesaka H, Kuwata T, Kunisawa J, Kiyono H, Takahashi H, Miura T, Hayami M. Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV. Virology. 2002 Jul 05; 298(2):306-16. PMID: 12127792.
      View in: PubMed
    261. Ohta N, Hiroi T, Kweon MN, Kinoshita N, Jang MH, Mashimo T, Miyazaki J, Kiyono H. IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation. J Immunol. 2002 Jul 01; 169(1):460-8. PMID: 12077277.
      View in: PubMed
    262. Fukuyama S, Hiroi T, Yokota Y, Rennert PD, Yanagita M, Kinoshita N, Terawaki S, Shikina T, Yamamoto M, Kurono Y, Kiyono H. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity. 2002 Jul; 17(1):31-40. PMID: 12150889.
      View in: PubMed
    263. Takahashi I, Matsuda J, Gapin L, DeWinter H, Kai Y, Tamagawa H, Kronenberg M, Kiyono H. Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice. Clin Immunol. 2002 Mar; 102(3):237-48. PMID: 11890710.
      View in: PubMed
    264. Kweon MN, Takahashi I, Yamamoto M, Jang MH, Suenobu N, Kiyono H. Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4(+) CD45RB(+) T cells. Gut. 2002 Mar; 50(3):299-306. PMID: 11839705.
      View in: PubMed
    265. Kweon MN, Kiyono H. CD40L in autoimmunity and mucosally induced tolerance. J Clin Invest. 2002 Jan; 109(2):171-3. PMID: 11805128.
      View in: PubMed
    266. Hamada H, Hiroi T, Nishiyama Y, Takahashi H, Masunaga Y, Hachimura S, Kaminogawa S, Takahashi-Iwanaga H, Iwanaga T, Kiyono H, Yamamoto H, Ishikawa H. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol. 2002 Jan 01; 168(1):57-64. PMID: 11751946.
      View in: PubMed
    267. Ohmura M, Yamamoto M, Kiyono H, Fujihashi K, Takeda Y, McGhee JR. Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin. Vaccine. 2001 Dec 12; 20(5-6):756-62. PMID: 11738739.
      View in: PubMed
    268. Hiroi T, Goto H, Someya K, Yanagita M, Honda M, Yamanaka N, Kiyono H. HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions. J Immunol. 2001 Nov 15; 167(10):5862-7. PMID: 11698461.
      View in: PubMed
    269. Jones HP, Hodge LM, Fujihashi K, Kiyono H, McGhee JR, Simecka JW. The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J Immunol. 2001 Oct 15; 167(8):4518-26. PMID: 11591779.
      View in: PubMed
    270. Yura M, Takahashi I, Terawaki S, Hiroi T, Kweon MN, Yuki Y, Kiyono H. Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE). Vaccine. 2001 Oct 12; 20(1-2):134-9. PMID: 11567757.
      View in: PubMed
    271. Schenck K, Kiyono H, Helgeland K, Steinsvoll S, Taylor B. Immunologic tolerance: the good, the bad, and the ugly. Acta Odontol Scand. 2001 Oct; 59(5):297-300. PMID: 11762300.
      View in: PubMed
    272. Kim JK, Takahashi I, Kai Y, Kiyono H. Influence of enterotoxin on mucosal intranet: selective inhibition of extrathymic T cell development in intestinal intraepithelial lymphocytes by oral exposure to heat-labile toxin. Eur J Immunol. 2001 Oct; 31(10):2960-9. PMID: 11592072.
      View in: PubMed
    273. Fujihashi K, Kato H, van Ginkel FW, Koga T, Boyaka PN, Jackson RJ, Kato R, Hagiwara Y, Etani Y, Goma I, Fujihashi K, Kiyono H, McGhee JR. A revisit of mucosal IgA immunity and oral tolerance. Acta Odontol Scand. 2001 Oct; 59(5):301-8. PMID: 11680650.
      View in: PubMed
    274. Dohi T, Rennert PD, Fujihashi K, Kiyono H, Shirai Y, Kawamura YI, Browning JL, McGhee JR. Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis. J Immunol. 2001 Sep 01; 167(5):2781-90. PMID: 11509623.
      View in: PubMed
    275. Yura M, Takahashi I, Serada M, Koshio T, Nakagami K, Yuki Y, Kiyono H. Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). J Autoimmun. 2001 Aug; 17(1):17-25. PMID: 11488634.
      View in: PubMed
    276. Schenck K, Helgeland K, Kiyono H. New Frontiers in Oral Immunological Diseases. Proceedings of a Conference. Lillehammer, Norway, 23-27 February 2001. Part 2. Acta Odontol Scand. 2001 Aug; 59(4):209-11. PMID: 11699491.
      View in: PubMed
    277. Kunisawa J, Nakanishi T, Takahashi I, Okudaira A, Tsutsumi Y, Katayama K, Nakagawa S, Kiyono H, Mayumi T. Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system. J Immunol. 2001 Aug 01; 167(3):1406-12. PMID: 11466359.
      View in: PubMed
    278. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T. NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport. 2001 Jul 20; 12(10):2079-84. PMID: 11447311.
      View in: PubMed
    279. Yuki Y, Byun Y, Fujita M, Izutani W, Suzuki T, Udaka S, Fujihashi K, McGhee JR, Kiyono H. Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis. Biotechnol Bioeng. 2001 Jul 05; 74(1):62-9. PMID: 11353411.
      View in: PubMed
    280. Shimizu M, Minakuchi K, Tsuda A, Hiroi T, Tanaka N, Koga J, Kiyono H. Role of stem cell factor and c-kit signaling in regulation of fetal intestinal epithelial cell adhesion to fibronectin. Exp Cell Res. 2001 Jun 10; 266(2):311-22. PMID: 11399059.
      View in: PubMed
    281. Kim JK, Takahashi I, Okuda Y, Itakura M, McGhee JR, Kiyono H. T cell receptor dynamism of mucosal and systemic CD4+ T cells in the course of an immune response to Escherichia coli heat-labile enterotoxin. J Infect Dis. 2001 Jul 01; 184(1):43-51. PMID: 11398108.
      View in: PubMed
    282. Kiyono H, Kweon MN, Hiroi T, Takahashi I. The mucosal immune system: from specialized immune defense to inflammation and allergy. Acta Odontol Scand. 2001 Jun; 59(3):145-53. PMID: 11501883.
      View in: PubMed
    283. Schenck K, Kiyono H. Innate and acquired immunity, cytokines, and genetic factors in relation to the mucosal immune system. Acta Odontol Scand. 2001 Jun; 59(3):121-3. PMID: 11501879.
      View in: PubMed
    284. Ohta N, Shimaoka M, Imanaka H, Nishimura M, Taenaka N, Kiyono H, Yoshiya I. Glucocorticoid suppresses neutrophil activation in ventilator-induced lung injury. Crit Care Med. 2001 May; 29(5):1012-6. PMID: 11378614.
      View in: PubMed
    285. Hodge LM, Marinaro M, Jones HP, McGhee JR, Kiyono H, Simecka JW. Immunoglobulin A (IgA) responses and IgE-associated inflammation along the respiratory tract after mucosal but not systemic immunization. Infect Immun. 2001 Apr; 69(4):2328-38. PMID: 11254590.
      View in: PubMed
    286. Fujihashi K, Dohi T, Rennert PD, Yamamoto M, Koga T, Kiyono H, McGhee JR. Peyer's patches are required for oral tolerance to proteins. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3310-5. PMID: 11248075.
      View in: PubMed
    287. Yamamoto M, McGhee JR, Hagiwara Y, Otake S, Kiyono H. Genetically manipulated bacterial toxin as a new generation mucosal adjuvant. Scand J Immunol. 2001 Mar; 53(3):211-7. PMID: 11251876.
      View in: PubMed
    288. Iijima H, Takahashi I, Kiyono H. Mucosal immune network in the gut for the control of infectious diseases. Rev Med Virol. 2001 Mar-Apr; 11(2):117-33. PMID: 11262530.
      View in: PubMed
    289. Kim J, Kiyono H. [The gastrointestinal immune system: cholera toxin and E. coli heat-labile enterotoxin as immunomodulators]. Tanpakushitsu Kakusan Koso. 2001 Mar; 46(4 Suppl):547-55. PMID: 11268659.
      View in: PubMed
    290. Byun Y, Ohmura M, Fujihashi K, Yamamoto S, McGhee JR, Udaka S, Kiyono H, Takeda Y, Kohsaka T, Yuki Y. Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies. Vaccine. 2001 Feb 28; 19(15-16):2061-70. PMID: 11228378.
      View in: PubMed
    291. Imanaka H, Shimaoka M, Matsuura N, Nishimura M, Ohta N, Kiyono H. Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta 1 mRNA upregulation in rat lungs. Anesth Analg. 2001 Feb; 92(2):428-36. PMID: 11159246.
      View in: PubMed
    292. Saito M, Otake S, Ohmura M, Hirasawa M, Takada K, Mega J, Takahashi I, Kiyono H, McGhee JR, Takeda Y, Yamamoto M. Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant. J Infect Dis. 2001 Mar 01; 183(5):823-6. PMID: 11181162.
      View in: PubMed
    293. Kweon M, Takahashi I, Kiyono H. New insights into mechanism of inflammatory and allergic diseases in mucosal tissues. Digestion. 2001; 63 Suppl 1:1-11. PMID: 11173903.
      View in: PubMed
    294. Kiyono H. Mucosal immune system: close encounter in the uncharted world of immunology. Ophthalmologica. 2001; 215 Suppl 1:22-32. PMID: 11276896.
      View in: PubMed
    295. Kunisawa J, Sakaue G, Kiyono H. [NALT immune system for the development of AIDS mucosal vaccine]. Nihon Rinsho Meneki Gakkai Kaishi. 2000 Dec; 23(6):579-81. PMID: 11210747.
      View in: PubMed
    296. Boyaka PN, Wright PF, Marinaro M, Kiyono H, Johnson JE, Gonzales RA, Ikizler MR, Werkhaven JA, Jackson RJ, Fujihashi K, Di Fabio S, Staats HF, McGhee JR. Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. Am J Pathol. 2000 Dec; 157(6):2023-35. PMID: 11106575.
      View in: PubMed
    297. Kishi D, Takahashi I, Kai Y, Tamagawa H, Iijima H, Obunai S, Nezu R, Ito T, Matsuda H, Kiyono H. Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice. J Immunol. 2000 Nov 15; 165(10):5891-9. PMID: 11067950.
      View in: PubMed
    298. Koga T, McGhee JR, Kato H, Kato R, Kiyono H, Fujihashi K. Evidence for early aging in the mucosal immune system. J Immunol. 2000 Nov 01; 165(9):5352-9. PMID: 11046071.
      View in: PubMed
    299. Hiroi T, Yanagita M, Ohta N, Sakaue G, Kiyono H. IL-15 and IL-15 receptor selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses. J Immunol. 2000 Oct 15; 165(8):4329-37. PMID: 11035068.
      View in: PubMed
    300. Kunisawa J, Okudaira A, Tsutusmi Y, Takahashi I, Nakanishi T, Kiyono H, Mayumi T. Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses. Vaccine. 2000 Oct 15; 19(4-5):589-94. PMID: 11027825.
      View in: PubMed
    301. Dohi T, Fujihashi K, Kiyono H, Elson CO, McGhee JR. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology. 2000 Sep; 119(3):724-33. PMID: 10982767.
      View in: PubMed
    302. Kweon MN, Yamamoto M, Kajiki M, Takahashi I, Kiyono H. Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea. J Clin Invest. 2000 Jul; 106(2):199-206. PMID: 10903335.
      View in: PubMed
    303. Yamamoto M, Kiyono H, Kweon MN, Yamamoto S, Fujihashi K, Kurazono H, Imaoka K, Bluethmann H, Takahashi I, Takeda Y, Azuma M, McGhee JR. Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses. J Infect Dis. 2000 Jul; 182(1):180-90. PMID: 10882596.
      View in: PubMed
    304. Yamamoto M, Rennert P, McGhee JR, Kweon MN, Yamamoto S, Dohi T, Otake S, Bluethmann H, Fujihashi K, Kiyono H. Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J Immunol. 2000 May 15; 164(10):5184-91. PMID: 10799877.
      View in: PubMed
    305. Higuchi K, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. Comparison of nasal and oral tolerance for the prevention of collagen induced murine arthritis. J Rheumatol. 2000 Apr; 27(4):1038-44. PMID: 10782834.
      View in: PubMed
    306. Simecka JW, Jackson RJ, Kiyono H, McGhee JR. Mucosally induced immunoglobulin E-associated inflammation in the respiratory tract. Infect Immun. 2000 Feb; 68(2):672-9. PMID: 10639432.
      View in: PubMed
    307. Saitoh-Inagawa W, Hiroi T, Yanagita M, Iijima H, Uchio E, Ohno S, Aoki K, Kiyono H. Unique characteristics of lacrimal glands as a part of mucosal immune network: high frequency of IgA-committed B-1 cells and NK1.1+ alphabeta T cells. Invest Ophthalmol Vis Sci. 2000 Jan; 41(1):138-44. PMID: 10634613.
      View in: PubMed
    308. Fujihashi K, Dohi T, Kweon MN, McGhee JR, Koga T, Cooper MD, Tonegawa S, Kiyono H. gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion. Int Immunol. 1999 Dec; 11(12):1907-16. PMID: 10590256.
      View in: PubMed
    309. Pascual DW, Hone DM, Hall S, van Ginkel FW, Yamamoto M, Walters N, Fujihashi K, Powell RJ, Wu S, Vancott JL, Kiyono H, McGhee JR. Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infect Immun. 1999 Dec; 67(12):6249-56. PMID: 10569734.
      View in: PubMed
    310. Mbawuike IN, Fujihashi K, DiFabio S, Kawabata S, McGhee JR, Couch RB, Kiyono H. Human interleukin-12 enhances interferon-gamma-producing influenza-specific memory CD8+ cytotoxic T lymphocytes. J Infect Dis. 1999 Nov; 180(5):1477-86. PMID: 10515806.
      View in: PubMed
    311. Tori M, Ito T, Yumiba T, Okawa A, Maeda A, Sawai T, Kiyomoto T, Akamaru Y, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. Proliferation of donor-derived NKR-P1+TCR alpha beta + (NKT) cells in the nonrecurrent spontaneous diabetic BB rats transplanted with pancreaticoduodenal grafts of Wistar-Furth donors. Transplant Proc. 1999 Nov; 31(7):2741-2. PMID: 10578272.
      View in: PubMed
    312. Kurono Y, Suzuki M, Mogi G, Yamamoto M, Fujihashi K, McGhee JR, Kiyono H. Effects of intranasal immunization on protective immunity against otitis media. Int J Pediatr Otorhinolaryngol. 1999 Oct 05; 49 Suppl 1:S227-9. PMID: 10577810.
      View in: PubMed
    313. Iijima H, Takahashi I, Kishi D, Kim JK, Kawano S, Hori M, Kiyono H. Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice. J Exp Med. 1999 Sep 06; 190(5):607-15. PMID: 10477546.
      View in: PubMed
    314. Takahashi I, Kiyono H. Gut as the largest immunologic tissue. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct; 23(5 Suppl):S7-12. PMID: 10483885.
      View in: PubMed
    315. Hoft DF, Kemp EB, Marinaro M, Cruz O, Kiyono H, McGhee JR, Belisle JT, Milligan TW, Miller JP, Belshe RB. A double-blind, placebo-controlled study of Mycobacterium-specific human immune responses induced by intradermal bacille Calmette-Guérin vaccination. J Lab Clin Med. 1999 Sep; 134(3):244-52. PMID: 10482309.
      View in: PubMed
    316. van Ginkel FW, Wahl SM, Kearney JF, Kweon MN, Fujihashi K, Burrows PD, Kiyono H, McGhee JR. Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice. J Immunol. 1999 Aug 15; 163(4):1951-7. PMID: 10438931.
      View in: PubMed
    317. Tori M, Ito T, Yumiba T, Ohkawa A, Maeda A, Sawai T, Kiyomoto T, Akamaru Y, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. IL-4 production in IDDM-nonrecurrent pancreas-transplanted BB rats with donor-derived NKR-P1+TCR alpha beta + (NKT) cells, but not in IDDM-recurrent BB rats. Transplant Proc. 1999 Aug; 31(5):1940-1. PMID: 10455925.
      View in: PubMed
    318. Kurono Y, Yamamoto M, Fujihashi K, Kodama S, Suzuki M, Mogi G, McGhee JR, Kiyono H. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. J Infect Dis. 1999 Jul; 180(1):122-32. PMID: 10353870.
      View in: PubMed
    319. Yamamoto M, Kiyono H, Yamamoto S, Batanero E, Kweon MN, Otake S, Azuma M, Takeda Y, McGhee JR. Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant. J Immunol. 1999 Jun 15; 162(12):7015-21. PMID: 10358143.
      View in: PubMed
    320. McGhee JR, Kiyono H, Kubota M, Kawabata S, Miller CJ, Lehner T, Imaoka K, Fujihashi K. Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques. J Infect Dis. 1999 May; 179 Suppl 3:S480-4. PMID: 10099124.
      View in: PubMed
    321. Dohi T, Fujihashi K, Rennert PD, Iwatani K, Kiyono H, McGhee JR. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med. 1999 Apr 19; 189(8):1169-80. PMID: 10209035.
      View in: PubMed
    322. Boyaka PN, Marinaro M, Vancott JL, Takahashi I, Fujihashi K, Yamamoto M, van Ginkel FW, Jackson RJ, Kiyono H, McGhee JR. Strategies for mucosal vaccine development. Am J Trop Med Hyg. 1999 Apr; 60(4 Suppl):35-45. PMID: 10344675.
      View in: PubMed
    323. Yanagita M, Hiroi T, Kitagaki N, Hamada S, Ito HO, Shimauchi H, Murakami S, Okada H, Kiyono H. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. J Immunol. 1999 Mar 15; 162(6):3559-65. PMID: 10092814.
      View in: PubMed
    324. Yamamoto M, Kiyono H. Immunoregulatory functions of mucosal gammadelta T cells. Microbes Infect. 1999 Mar; 1(3):241-6. PMID: 10801236.
      View in: PubMed
    325. Kweon MN, Fujihashi K, Wakatsuki Y, Koga T, Yamamoto M, McGhee JR, Kiyono H. Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions. J Immunol. 1999 Feb 15; 162(4):1904-9. PMID: 9973457.
      View in: PubMed
    326. Takahashi I, Iijima H, Katashima R, Itakura M, Kiyono H. Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain- deficient mice by gut-derived antigens. J Immunol. 1999 Feb 01; 162(3):1843-50. PMID: 9973450.
      View in: PubMed
    327. Nguyen HH, Moldoveanu Z, Novak MJ, van Ginkel FW, Ban E, Kiyono H, McGhee JR, Mestecky J. Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues. Virology. 1999 Feb 01; 254(1):50-60. PMID: 9927573.
      View in: PubMed
    328. Hiroi T, Yanagita M, Iijima H, Iwatani K, Yoshida T, Takatsu K, Kiyono H. Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues. J Immunol. 1999 Jan 15; 162(2):821-8. PMID: 9916704.
      View in: PubMed
    329. Boyaka PN, Marinaro M, Jackson RJ, Menon S, Kiyono H, Jirillo E, McGhee JR. IL-12 is an effective adjuvant for induction of mucosal immunity. J Immunol. 1999 Jan 01; 162(1):122-8. PMID: 9886377.
      View in: PubMed
    330. Tori M, Ito T, Yumiba T, Maeda A, Sawai T, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. Significant role of intragraft lymphoid tissues in preventing insulin-dependent diabetes mellitus recurrence in whole pancreaticoduodenal transplantation. Microsurgery. 1999; 19(7):338-43. PMID: 10586200.
      View in: PubMed
    331. Sugimoto M, Shimaoka M, Taenaka N, Kiyono H, Yoshiya I. Lymphocyte activation is attenuated by stellate ganglion block. Reg Anesth Pain Med. 1999 Jan-Feb; 24(1):30-5. PMID: 9952092.
      View in: PubMed
    332. Takahashi I, Lijima H, Kishi D, Kiyono H. Oligoclonal Th2-biased betabeta T cells induce murine inflammatory bowel disease. Immunol Res. 1999; 20(3):237-42. PMID: 10741863.
      View in: PubMed
    333. Marinaro M, Boyaka PN, Jackson RJ, Finkelman FD, Kiyono H, Jirillo E, McGhee JR. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin. J Immunol. 1999 Jan 01; 162(1):114-21. PMID: 9886376.
      View in: PubMed
    334. Kobayashi T, Yamamoto M, Hiroi T, McGhee J, Takeshita Y, Kiyono H. Arginine enhances induction of T helper 1 and T helper 2 cytokine synthesis by Peyer's patch alpha beta T cells and antigen-specific mucosal immune response. Biosci Biotechnol Biochem. 1998 Dec; 62(12):2334-40. PMID: 9972259.
      View in: PubMed
    335. Shimaoka M, Hosotsubo K, Sugimoto M, Sakaue G, Taenaka N, Yoshiya I, Kiyono H. The influence of surgical stress on T cells: enhancement of early phase lymphocyte activation. Anesth Analg. 1998 Dec; 87(6):1431-5. PMID: 9842843.
      View in: PubMed
    336. Imaoka K, Miller CJ, Kubota M, McChesney MB, Lohman B, Yamamoto M, Fujihashi K, Someya K, Honda M, McGhee JR, Kiyono H. Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues. J Immunol. 1998 Dec 01; 161(11):5952-8. PMID: 9834076.
      View in: PubMed
    337. Iijima H, Takahashi I, Hiroi T, Shimaoka M, Kawano S, Nagano K, Hori M, Kiyono H. Orally administered cholera toxin prevents murine intestinal T cells from staphylococcal enterotoxin B-induced anergy. Gastroenterology. 1998 Nov; 115(5):1197-204. PMID: 9797375.
      View in: PubMed
    338. Harris PR, Ernst PB, Kawabata S, Kiyono H, Graham MF, Smith PD. Recombinant Helicobacter pylori urease activates primary mucosal macrophages. J Infect Dis. 1998 Nov; 178(5):1516-20. PMID: 9780278.
      View in: PubMed
    339. VanCott JL, Chatfield SN, Roberts M, Hone DM, Hohmann EL, Pascual DW, Yamamoto M, Kiyono H, McGhee JR. Regulation of host immune responses by modification of Salmonella virulence genes. Nat Med. 1998 Nov; 4(11):1247-52. PMID: 9809547.
      View in: PubMed
    340. Itoh M, Ishihara K, Hiroi T, Lee BO, Maeda H, Iijima H, Yanagita M, Kiyono H, Hirano T. Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J Immunol. 1998 Oct 15; 161(8):3974-83. PMID: 9780166.
      View in: PubMed
    341. Yamamoto M, Briles DE, Yamamoto S, Ohmura M, Kiyono H, McGhee JR. A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A. J Immunol. 1998 Oct 15; 161(8):4115-21. PMID: 9780183.
      View in: PubMed
    342. Kawabata S, Boyaka PN, Coste M, Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics. Gastroenterology. 1998 Oct; 115(4):866-73. PMID: 9753489.
      View in: PubMed
    343. Hiroi T, Iwatani K, Iijima H, Kodama S, Yanagita M, Kiyono H. Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively. Eur J Immunol. 1998 10; 28(10):3346-53. PMID: 9808204.
      View in: PubMed
    344. Marinaro M, Boyaka PN, Kiyono H, McGhee JR. Novel approaches for the induction of T helper 1 (Th1)- or Th2-type mucosal and parenteral immune responses. Expert Opin Investig Drugs. 1998 Oct; 7(10):1657-66. PMID: 15991907.
      View in: PubMed
    345. Dohi T, Kiyono H. [Dysregulation of mucosal immunity and inflammatory bowel diseases]. Nihon Rinsho. 1998 Jun; 56(6):1619-26. PMID: 9648492.
      View in: PubMed
    346. Salvi GE, Brown CE, Fujihashi K, Kiyono H, Smith FW, Beck JD, Offenbacher S. Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. J Periodontal Res. 1998 May; 33(4):212-25. PMID: 9689617.
      View in: PubMed
    347. Nguyen HH, Boyaka PN, Moldoveanu Z, Novak MJ, Kiyono H, McGhee JR, Mestecky J. Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes. J Virol. 1998 May; 72(5):4534-6. PMID: 9557755.
      View in: PubMed
    348. Sugimoto M, Shimaoka M, Hosotsubo K, Tanigami H, Taenaka N, Kiyono H, Yoshiya I. Up-regulation of Fas ligand (FasL) mRNA expression in peripheral blood mononuclear cells (PBMC) after major surgery. Clin Exp Immunol. 1998 Apr; 112(1):120-5. PMID: 9566799.
      View in: PubMed
    349. Yuki Y, Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Human milk proteins including secretory IgA fail to elicit tolerance after feeding. Int Immunol. 1998 Apr; 10(4):537-45. PMID: 9620610.
      View in: PubMed
    350. Yamamoto M, Fujihashi K, Kawabata K, McGhee JR, Kiyono H. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J Immunol. 1998 Mar 01; 160(5):2188-96. PMID: 9498757.
      View in: PubMed
    351. Kweon MN, Fujihashi K, VanCott JL, Higuchi K, Yamamoto M, McGhee JR, Kiyono H. Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice. J Immunol. 1998 Feb 15; 160(4):1687-93. PMID: 9469425.
      View in: PubMed
    352. Kawabata S, Miller CJ, Lehner T, Fujihashi K, Kubota M, McGhee JR, Imaoka K, Hiroi T, Kiyono H. Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques. J Infect Dis. 1998 Jan; 177(1):26-33. PMID: 9419166.
      View in: PubMed
    353. Wilcox CM, Harris PR, Redman TK, Kawabata S, Hiroi T, Kiyono H, Smith PD. High mucosal levels of tumor necrosis factor alpha messenger RNA in AIDS-associated cytomegalovirus-induced esophagitis. Gastroenterology. 1998 Jan; 114(1):77-82. PMID: 9428221.
      View in: PubMed
    354. Lü X, Kiyono H, Lu D, Kawabata S, Torten J, Srinivasan S, Dailey PJ, McGhee JR, Lehner T, Miller CJ. Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251. AIDS. 1998 Jan 01; 12(1):1-10. PMID: 9456249.
      View in: PubMed
    355. Takahashi I, Kiyono H. Gamma delta T cells: bodyguards and/or sleepers in the gut. Chem Immunol. 1998; 71:77-87. PMID: 9761948.
      View in: PubMed
    356. Kawabata S, Boyaka PN, Coste M, Fujihashi K, Hamada S, McGhee JR, Kiyono H. A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine. Biochem Biophys Res Commun. 1997 Dec 29; 241(3):797-802. PMID: 9434789.
      View in: PubMed
    357. Yamada K, Shimaoka M, Nagayama K, Hiroi T, Kiyono H, Honda T. Bacterial invasion induces interleukin-7 receptor expression in colonic epithelial cell line, T84. Eur J Immunol. 1997 Dec; 27(12):3456-60. PMID: 9464835.
      View in: PubMed
    358. Pascual DW, Coste M, Boyaka PN, Kiyono H, McGhee JR. Spontaneously hypertensive rat: cholera toxin converts suppression to immunity through a Th2 cell-IL-4 pathway. Am J Physiol. 1997 10; 273(4):R1509-18. PMID: 9362318.
      View in: PubMed
    359. Fujihashi K, McGhee JR, Yamamoto M, Peschon JJ, Kiyono H. An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state. Eur J Immunol. 1997 Sep; 27(9):2133-8. PMID: 9341750.
      View in: PubMed
    360. van Ginkel FW, McGhee JR, Liu C, Simecka JW, Yamamoto M, Frizzell RA, Sorscher EJ, Kiyono H, Pascual DW. Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene. J Immunol. 1997 Jul 15; 159(2):685-93. PMID: 9218583.
      View in: PubMed
    361. Kubota M, Miller CJ, Imaoka K, Kawabata S, Fujihashi K, McGhee JR, Kiyono H. Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates. J Immunol. 1997 Jun 01; 158(11):5321-9. PMID: 9164952.
      View in: PubMed
    362. Yamamoto M, Kweon MN, Kiyono H. [The mechanisms of oral tolerance]. Nihon Rinsho. 1997 Jun; 55(6):1444-9. PMID: 9200930.
      View in: PubMed
    363. Takahashi I, Kiyono H, Hamada S. CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice. Gastroenterology. 1997 Jun; 112(6):1876-86. PMID: 9178680.
      View in: PubMed
    364. Ban EM, van Ginkel FW, Simecka JW, Kiyono H, Robinson HL, McGhee JR. Mucosal immunization with DNA encoding influenza hemagglutinin. Vaccine. 1997 Jun; 15(8):811-3. PMID: 9234521.
      View in: PubMed
    365. Yamamoto S, Kiyono H, Yamamoto M, Imaoka K, Fujihashi K, Van Ginkel FW, Noda M, Takeda Y, McGhee JR. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5267-72. PMID: 9144226.
      View in: PubMed
    366. Yamamoto S, Takeda Y, Yamamoto M, Kurazono H, Imaoka K, Yamamoto M, Fujihashi K, Noda M, Kiyono H, McGhee JR. Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. J Exp Med. 1997 Apr 07; 185(7):1203-10. PMID: 9104807.
      View in: PubMed
    367. Marinaro M, Boyaka PN, Finkelman FD, Kiyono H, Jackson RJ, Jirillo E, McGhee JR. Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses. J Exp Med. 1997 Feb 03; 185(3):415-27. PMID: 9053442.
      View in: PubMed
    368. Yanagita M, Hiroi T, Kiyono H. [Mucosal immune system and mucosal vaccine]. Nihon Rinsho. 1997 Feb; 55(2):492-501. PMID: 9046845.
      View in: PubMed
    369. Yamamoto M, McDaniel LS, Kawabata K, Briles DE, Jackson RJ, McGhee JR, Kiyono H. Oral immunization with PspA elicits protective humoral immunity against Streptococcus pneumoniae infection. Infect Immun. 1997 Feb; 65(2):640-4. PMID: 9009325.
      View in: PubMed
    370. Sabbaj S, Kiyono H, McGhee JR. [Not Available]. BioDrugs. 1997 Feb; 7(2):134-57. PMID: 18031087.
      View in: PubMed
    371. Vancott JL, Kweon M, Fujihashi K, Yamamoto M, Marinaro M, Kiyono H, McGhee JR. Helper T subsets and cytokines for mucosal immunity and tolerance. Behring Inst Mitt. 1997 Feb; (98):44-52. PMID: 9382768.
      View in: PubMed
    372. Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodontal Res. 1997 Jan; 32(1 Pt 2):115-9. PMID: 9085220.
      View in: PubMed
    373. Fujihashi K, Kweon MN, Kiyono H, VanCott JL, van Ginkel FW, Yamamoto M, McGhee JR. A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity. Springer Semin Immunopathol. 1997; 18(4):477-94. PMID: 9144866.
      View in: PubMed
    374. Wallace M, Scharko AM, Pauza CD, Fisch P, Imaoka K, Kawabata S, Fujihashi K, Kiyono H, Tanaka Y, Bloom BR, Malkovsky M. Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections. Mol Med. 1997 Jan; 3(1):60-71. PMID: 9132281.
      View in: PubMed
    375. Marinaro M, Boyaka PN, Jackson RJ, Finkelman FD, Kiyono H, McGhee JR. Interleukin-12 alters helper T-cell subsets and antibody profiles induced by the mucosal adjuvant cholera toxin. Ann N Y Acad Sci. 1996 Oct 31; 795:361-5. PMID: 8958955.
      View in: PubMed
    376. Elson CO, Beagley KW, Sharmanov AT, Fujihashi K, Kiyono H, Tennyson GS, Cong Y, Black CA, Ridwan BW, McGhee JR. Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. J Immunol. 1996 Sep 01; 157(5):2174-85. PMID: 8757344.
      View in: PubMed
    377. Nakagawa I, Takahashi I, Kiyono H, McGhee JR, Hamada S. Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches. J Infect Dis. 1996 Jun; 173(6):1428-36. PMID: 8648216.
      View in: PubMed
    378. Okahashi N, Yamamoto M, Vancott JL, Chatfield SN, Roberts M, Bluethmann H, Hiroi T, Kiyono H, McGhee JR. Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect Immun. 1996 May; 64(5):1516-25. PMID: 8613355.
      View in: PubMed
    379. Jackson RJ, Fujihashi K, Kiyono H, McGhee JR. Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses. J Immunol Methods. 1996 Apr 19; 190(2):189-97. PMID: 8621954.
      View in: PubMed
    380. Fujihashi K, Kawabata S, Hiroi T, Yamamoto M, McGhee JR, Nishikawa S, Kiyono H. Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3613-8. PMID: 8622984.
      View in: PubMed
    381. Takahashi I, Kiyono H, Jackson RJ, Fujihashi K, Staats HF, Hamada S, Clements JD, Bost KL, McGhee JR. Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. Infect Immun. 1996 Apr; 64(4):1290-8. PMID: 8606092.
      View in: PubMed
    382. VanCott JL, Kobayashi T, Yamamoto M, Pillai S, McGhee JR, Kiyono H. Induction of pneumococcal polysaccharide-specific mucosal immune responses by oral immunization. Vaccine. 1996 Apr; 14(5):392-8. PMID: 8735550.
      View in: PubMed
    383. Fujihashi K, McGhee JR, Kweon MN, Cooper MD, Tonegawa S, Takahashi I, Hiroi T, Mestecky J, Kiyono H. gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses. J Exp Med. 1996 Apr 01; 183(4):1929-35. PMID: 8666951.
      View in: PubMed
    384. Fujihashi K, Yamamoto M, Hiroi T, Bamberg TV, McGhee JR, Kiyono H. Selected Th1 and Th2 cytokine mRNA expression by CD4(+) T cells isolated from inflamed human gingival tissues. Clin Exp Immunol. 1996 Mar; 103(3):422-8. PMID: 8608641.
      View in: PubMed
    385. Takahashi I, Marinaro M, Kiyono H, Jackson RJ, Nakagawa I, Fujihashi K, Hamada S, Clements JD, Bost KL, McGhee JR. Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin. J Infect Dis. 1996 Mar; 173(3):627-35. PMID: 8627026.
      View in: PubMed
    386. VanCott JL, Staats HF, Pascual DW, Roberts M, Chatfield SN, Yamamoto M, Coste M, Carter PB, Kiyono H, McGhee JR. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J Immunol. 1996 Feb 15; 156(4):1504-14. PMID: 8568254.
      View in: PubMed
    387. Yamamoto M, Vancott JL, Okahashi N, Marinaro M, Kiyono H, Fujihashi K, Jackson RJ, Chatfield SN, Bluethmann H, McGhee JR. The role of Th1 and Th2 cells for mucosal IgA responses. Ann N Y Acad Sci. 1996 Feb 13; 778:64-71. PMID: 8611017.
      View in: PubMed
    388. Fujihashi K, McGhee JR, Yamamoto M, Hiroi T, Kiyono H. Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance. Ann N Y Acad Sci. 1996 Feb 13; 778:55-63. PMID: 8611016.
      View in: PubMed
    389. Shimaoka M, Hiroi T, Kiyono H. [The IgA immune system for mucosal vaccine: role of levels one and two Th2 cytokine producing T cells]. Nihon Rinsho Meneki Gakkai Kaishi. 1996 Feb; 19(1):114-8. PMID: 8681023.
      View in: PubMed
    390. Jackson RJ, Marinaro M, VanCott JL, Yamamoto M, Okahashi N, Fujihashi K, Kiyono H, Chatfield SN, McGhee JR. Mucosal immunity: regulation by helper T cells and a novel method for detection. J Biotechnol. 1996 Jan 26; 44(1-3):209-16. PMID: 8717406.
      View in: PubMed
    391. Simpson SD, Snider DP, Zettel LA, Kiyono H, Unkeless JC, Ernst PB. Soluble FcR block suppressor T cell activity at low concentration in vitro allowing isotype-specific antibody production. Cell Immunol. 1996 Jan 10; 167(1):122-8. PMID: 8548835.
      View in: PubMed
    392. Yamamoto M, Kawabata K, Fujihashi K, McGhee JR, Van Dyke TE, Bamberg TV, Hiroi T, Kiyono H. Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases. Am J Pathol. 1996 Jan; 148(1):331-9. PMID: 8546223.
      View in: PubMed
    393. Kiyono H. [Immune mechanism of mucous membrane and mucous membrane vaccines: Expression of level 1 and 2 Th2-type cytokine and IgA immune response]. Nihon Rinsho Meneki Gakkai Kaishi. 1995 Dec; 18(6):690. PMID: 8963788.
      View in: PubMed
    394. Marinaro M, Staats HF, Hiroi T, Jackson RJ, Coste M, Boyaka PN, Okahashi N, Yamamoto M, Kiyono H, Bluethmann H, Fujihashi K, McGhee JR. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol. 1995 Nov 15; 155(10):4621-9. PMID: 7594461.
      View in: PubMed
    395. Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells. Eur J Immunol. 1995 Oct; 25(10):2743-51. PMID: 7589066.
      View in: PubMed
    396. Bukawa H, Sekigawa K, Hamajima K, Fukushima J, Yamada Y, Kiyono H, Okuda K. Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. Nat Med. 1995 Jul; 1(7):681-5. PMID: 7585151.
      View in: PubMed
    397. Van Ginkel FW, Liu C, Simecka JW, Dong JY, Greenway T, Frizzell RA, Kiyono H, McGhee JR, Pascual DW. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase. Hum Gene Ther. 1995 Jul; 6(7):895-903. PMID: 7578408.
      View in: PubMed
    398. Takahashi I, Nakagawa I, Kiyono H, McGhee JR, Clements JD, Hamada S. Mucosal T cells induce systemic anergy for oral tolerance. Biochem Biophys Res Commun. 1995 Jan 05; 206(1):414-20. PMID: 7818546.
      View in: PubMed
    399. Pascual DW, Beagley KW, Kiyono H, McGhee JR. Substance P promotes Peyer's patch and splenic B cell differentiation. Adv Exp Med Biol. 1995; 371A:55-9. PMID: 8525987.
      View in: PubMed
    400. Novak M, Yamamoto M, Fujihashi K, Moldoveanu Z, Kiyono H, McGhee JR, Mestecky J. Ig-secreting and interferon-gamma-producing cells in mice mucosally immunized with influenza virus. Adv Exp Med Biol. 1995; 371B:1587-90. PMID: 7502861.
      View in: PubMed
    401. Mega J, McGhee JR, Kiyono H. Characterization of cytokine producing T cells, TCR expression, and IgA plasma cells in salivary gland-associated tissues. Adv Exp Med Biol. 1995; 371B:1103-8. PMID: 7502762.
      View in: PubMed
    402. Aicher WK, Eibel H, Fujihashi K, Boehm T, Beagley KW, McGhee JR, Kiyono H. Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenes. Adv Exp Med Biol. 1995; 371A:125-8. PMID: 8525887.
      View in: PubMed
    403. Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues. Eur J Immunol. 1994 Nov; 24(11):2653-8. PMID: 7957557.
      View in: PubMed
    404. Jackson RJ, Staats HF, Xu-Amano J, Takahashi I, Kiyono H, Hudson ME, Gilley RM, Chatfield SN, McGhee JR. Oral vaccine models: multiple delivery systems employing tetanus toxoid. Ann N Y Acad Sci. 1994 Aug 15; 730:217-34. PMID: 8080173.
      View in: PubMed
    405. Staats HF, Jackson RJ, Marinaro M, Takahashi I, Kiyono H, McGhee JR. Mucosal immunity to infection with implications for vaccine development. Curr Opin Immunol. 1994 Aug; 6(4):572-83. PMID: 7946045.
      View in: PubMed
    406. Pascual DW, Kiyono H, McGhee JR. The enteric nervous and immune systems: interactions for mucosal immunity and inflammation. Immunomethods. 1994 Aug; 5(1):56-72. PMID: 7531102.
      View in: PubMed
    407. Xu-Amano J, Jackson RJ, Fujihashi K, Kiyono H, Staats HF, McGhee JR. Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. Vaccine. 1994 Aug; 12(10):903-11. PMID: 7975832.
      View in: PubMed
    408. Yamamoto M, Fujihashi K, Amano M, McGhee JR, Beagley KW, Kiyono H. Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 production, while low density T cells undergo DNA fragmentation. Eur J Immunol. 1994 Jun; 24(6):1301-6. PMID: 8206090.
      View in: PubMed
    409. McGhee JR, Xu-Amano J, Miller CJ, Jackson RJ, Fujihashi K, Staats HF, Kiyono H. The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reprod Fertil Dev. 1994; 6(3):369-79. PMID: 7831485.
      View in: PubMed
    410. McGhee JR, Kiyono H. Effective mucosal immunity. Current concepts for vaccine delivery and immune response analysis. Int J Technol Assess Health Care. 1994; 10(1):93-106. PMID: 8157466.
      View in: PubMed
    411. Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Function of alpha beta TCR+ and gamma delta TCR+ IELs for the gastrointestinal immune response. Int Rev Immunol. 1994; 11(1):1-14. PMID: 8057042.
      View in: PubMed
    412. Di Fabio S, Mbawuike IN, Kiyono H, Fujihashi K, Couch RB, McGhee JR. Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells. Int Immunol. 1994 Jan; 6(1):11-9. PMID: 8148319.
      View in: PubMed
    413. Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses. J Immunol. 1993 Dec 15; 151(12):6681-91. PMID: 7903096.
      View in: PubMed
    414. Fujihashi K, Yamamoto M, McGhee JR, Beagley KW, Kiyono H. Function of alpha beta TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8- and CD4+CD8+ T cells for helper activity. Int Immunol. 1993 Nov; 5(11):1473-81. PMID: 8260458.
      View in: PubMed
    415. McGhee JR, Fujihashi K, Xu-Amano J, Jackson RJ, Elson CO, Beagley KW, Kiyono H. New perspectives in mucosal immunity with emphasis on vaccine development. Semin Hematol. 1993 Oct; 30(4 Suppl 4):3-12; discussion 13-5. PMID: 8303308.
      View in: PubMed
    416. Xu-Amano J, Kiyono H, Jackson RJ, Staats HF, Fujihashi K, Burrows PD, Elson CO, Pillai S, McGhee JR. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med. 1993 Oct 01; 178(4):1309-20. PMID: 8376936.
      View in: PubMed
    417. Jackson RJ, Fujihashi K, Xu-Amano J, Kiyono H, Elson CO, McGhee JR. Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect Immun. 1993 Oct; 61(10):4272-9. PMID: 8406816.
      View in: PubMed
    418. Amano M, McGhee JR, McCutcheon MJ, Fujii K, Kiyono H. Application of the ILISPOT-IDIP system for the enumeration of different sizes of IgA spot forming cells in the murine small and large intestine. J Immunol Methods. 1993 Aug 26; 164(1):79-90. PMID: 8360511.
      View in: PubMed
    419. Beagley KW, Fujihashi K, Black CA, Lagoo AS, Yamamoto M, McGhee JR, Kiyono H. The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. Eur J Immunol. 1993 Aug; 23(8):2049-52. PMID: 8344373.
      View in: PubMed
    420. Fujihashi K, Kono Y, Beagley KW, Yamamoto M, McGhee JR, Mestecky J, Kiyono H. Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues. J Periodontol. 1993 May; 64(5 Suppl):400-6. PMID: 8315562.
      View in: PubMed
    421. Sarawar SR, Carding SR, Allan W, McMickle A, Fujihashi K, Kiyono H, McGhee JR, Doherty PC. Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: consequences of CD4+ and CD8+ T cell depletion. Reg Immunol. 1993 May-Aug; 5(3-4):142-50. PMID: 7902123.
      View in: PubMed
    422. Fujihashi K, McGhee JR, Beagley KW, McPherson DT, McPherson SA, Huang CM, Kiyono H. Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells. J Immunol Methods. 1993 Apr 02; 160(2):181-9. PMID: 8459105.
      View in: PubMed
    423. Fujihashi K, Beagley KW, Kono Y, Aicher WK, Yamamoto M, DiFabio S, Xu-Amano J, McGhee JR, Kiyono H. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol. 1993 Apr; 142(4):1239-50. PMID: 8475996.
      View in: PubMed
    424. McGhee JR, Kiyono H. New perspectives in vaccine development: mucosal immunity to infections. Infect Agents Dis. 1993 Apr; 2(2):55-73. PMID: 8162356.
      View in: PubMed
    425. Yamamoto M, Fujihashi K, Beagley KW, McGhee JR, Kiyono H. Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5. J Immunol. 1993 Jan 01; 150(1):106-14. PMID: 8417116.
      View in: PubMed
    426. Aicher WK, Fujihashi K, Yamamoto M, Kiyono H, Pitts AM, McGhee JR. Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site. Int Immunol. 1992 Sep; 4(9):959-68. PMID: 1390438.
      View in: PubMed
    427. Ogawa T, Kusumoto Y, Kiyono H, McGhee JR, Hamada S. Occurrence of antigen-specific B cells following oral or parenteral immunization with Porphyromonas gingivalis fimbriae. Int Immunol. 1992 Sep; 4(9):1003-10. PMID: 1356427.
      View in: PubMed
    428. Fujihashi K, Kono Y, Kiyono H. Effects of IL6 on B cells in mucosal immune response and inflammation. Res Immunol. 1992 Sep; 143(7):744-9. PMID: 1439148.
      View in: PubMed
    429. McGhee JR, Yamamoto M, Kang DW, Eldridge JH, Mestecky J, Moldoveanu Z, Compans R, Kiyono H, Miller C, Marthas M. Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routes. AIDS Res Hum Retroviruses. 1992 Aug; 8(8):1389. PMID: 1466963.
      View in: PubMed
    430. Miller CJ, Kang DW, Marthas M, Moldoveanu Z, Kiyono H, Marx P, Eldridge JH, Mestecky J, McGhee JR. Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: a comparison between intravenously and genitally inoculated rhesus macaques. Clin Exp Immunol. 1992 Jun; 88(3):520-6. PMID: 1606737.
      View in: PubMed
    431. Aicher WK, McGhee ML, McGhee JR, Moldoveanu Z, Kidd VJ, Tomana M, Mestecky J, Eldridge JH, Meyer TF, Kiyono H. Properties of IgA-binding receptors on murine T cells: relative importance of Fc alpha R, beta-galactosyltransferase and anti-secretory component reactive proteins (ASCP). Scand J Immunol. 1992 Apr; 35(4):469-86. PMID: 1557614.
      View in: PubMed
    432. Mega J, McGhee JR, Kiyono H. Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues. J Immunol. 1992 Apr 01; 148(7):2030-9. PMID: 1545116.
      View in: PubMed
    433. Xu-Amano J, Aicher WK, Taguchi T, Kiyono H, McGhee JR. Selective induction of Th2 cells in murine Peyer's patches by oral immunization. Int Immunol. 1992 Apr; 4(4):433-45. PMID: 1534253.
      View in: PubMed
    434. Pascual DW, Bost KL, Xu-Amano J, Kiyono H, McGhee JR. The cytokine-like action of substance P upon B cell differentiation. Reg Immunol. 1992 Mar-Apr; 4(2):100-4. PMID: 1380278.
      View in: PubMed
    435. Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone JA, Eldridge JH, Kiyono H. Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. J Exp Med. 1992 Mar 01; 175(3):695-707. PMID: 1531495.
      View in: PubMed
    436. Mega J, Fujihashi K, Kiyono H. Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis. Reg Immunol. 1992 Mar-Apr; 4(2):70-8. PMID: 1354470.
      View in: PubMed
    437. Kiyono H, Bienenstock J, McGhee JR, Ernst PB. The mucosal immune system: features of inductive and effector sites to consider in mucosal immunization and vaccine development. Reg Immunol. 1992 Mar-Apr; 4(2):54-62. PMID: 1503889.
      View in: PubMed
    438. Lue C, Kiyono H, Fujihashi K, McGhee JR, Mestecky J. The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigens. Reg Immunol. 1992 Mar-Apr; 4(2):86-90. PMID: 1503891.
      View in: PubMed
    439. Marthas ML, Miller CJ, Sutjipto S, Higgins J, Torten J, Lohman BL, Unger RE, Ramos RA, Kiyono H, McGhee JR. Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV. J Med Primatol. 1992 Feb-May; 21(2-3):99-107. PMID: 1433273.
      View in: PubMed
    440. Xu-Amano J, Beagley KW, Mega J, Fujihashi K, Kiyono H, McGhee JR. Induction of T helper cells and cytokines for mucosal IgA responses. Adv Exp Med Biol. 1992; 327:107-17. PMID: 1295331.
      View in: PubMed
    441. McGhee JR, Mestecky J, Dertzbaugh MT, Eldridge JH, Hirasawa M, Kiyono H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine. 1992; 10(2):75-88. PMID: 1539467.
      View in: PubMed
    442. Mega J, Fujihashi K, Yamamoto M, McGhee JR, Hirasawa M, Kiyono H. Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA response. Adv Exp Med Biol. 1992; 327:119-31. PMID: 1295332.
      View in: PubMed
    443. McGhee JR, Kiyono H. Mucosal immunity to vaccines: current concepts for vaccine development and immune response analysis. Adv Exp Med Biol. 1992; 327:3-12. PMID: 1295349.
      View in: PubMed
    444. Aicher WK, Fujihashi K, Taguchi T, McGhee JR, Yamamoto M, Eldridge JH, Gay S, Kiyono H. Intestinal intraepithelial lymphocyte T cells are resistant to lpr gene-induced T cell abnormalities. Eur J Immunol. 1992 Jan; 22(1):137-45. PMID: 1346108.
      View in: PubMed
    445. Taguchi T, Aicher WK, Fujihashi K, Yamamoto M, McGhee JR, Bluestone JA, Kiyono H. Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol. 1991 Dec 01; 147(11):3736-44. PMID: 1682383.
      View in: PubMed
    446. Pascual DW, McGhee JR, Kiyono H, Bost KL. Neuroimmune modulation of lymphocyte function--I. Substance P enhances immunoglobulin synthesis in lipopolysaccharide activated murine splenic B cell cultures. Int Immunol. 1991 Dec; 3(12):1223-9. PMID: 1723293.
      View in: PubMed
    447. Amano M, Martin JC, McGhee JR, McCutcheon MJ, Kiyono H. Immunofluorescence-digital image processing system for the quantitation of secreted immunoglobulin by single cells. J Immunol Methods. 1991 Nov 05; 144(1):127-40. PMID: 1960401.
      View in: PubMed
    448. Pascual DW, Bost KL, Xu-Amano J, Kiyono H, McGhee JR. The regulation of antibody responses by mini-cytokines. Acta Neurol (Napoli). 1991 Aug; 13(4):343-9. PMID: 1723564.
      View in: PubMed
    449. Fujihashi K, McGhee JR, Lue C, Beagley KW, Taga T, Hirano T, Kishimoto T, Mestecky J, Kiyono H. Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis. J Clin Invest. 1991 Jul; 88(1):248-52. PMID: 2056119.
      View in: PubMed
    450. Pascual DW, Xu-Amano JC, Kiyono H, McGhee JR, Bost KL. Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production. J Immunol. 1991 Apr 01; 146(7):2130-6. PMID: 1706387.
      View in: PubMed
    451. Kono Y, Beagley KW, Fujihashi K, McGhee JR, Taga T, Hirano T, Kishimoto T, Kiyono H. Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva. J Immunol. 1991 Mar 15; 146(6):1812-21. PMID: 2005380.
      View in: PubMed
    452. Beagley KW, Eldridge JH, Aicher WK, Mestecky J, Di Fabio S, Kiyono H, McGhee JR. Peyer's patch B cells with memory cell characteristics undergo terminal differentiation within 24 hours in response to interleukin-6. Cytokine. 1991 Mar; 3(2):107-16. PMID: 1909587.
      View in: PubMed
    453. Ogawa T, Kono Y, McGhee ML, McGhee JR, Roberts JE, Hamada S, Kiyono H. Porphyromonas gingivalis-specific serum IgG and IgA antibodies originate from immunoglobulin-secreting cells in inflamed gingiva. Clin Exp Immunol. 1991 Feb; 83(2):237-44. PMID: 1671564.
      View in: PubMed
    454. Lue C, Kiyono H, McGhee JR, Fujihashi K, Kishimoto T, Hirano T, Mestecky J. Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells. Cell Immunol. 1991 Feb; 132(2):423-32. PMID: 1988161.
      View in: PubMed
    455. McGhee JR, Fujihashi K, Beagley KW, Kiyono H. Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses. Immunol Res. 1991; 10(3-4):418-22. PMID: 1955769.
      View in: PubMed
    456. Kiyono H, Fujihashi K, Taguchi T, Aicher WK, McGhee JR. Regulatory functions for murine intraepithelial lymphocytes in mucosal responses. Immunol Res. 1991; 10(3-4):324-30. PMID: 1955757.
      View in: PubMed
    457. McGhee JR, Fujihashi K, Lue C, Beagley KW, Mestecky J, Kiyono H. Role of IL-6 in human antigen-specific and polyclonal IgA responses. Adv Exp Med Biol. 1991; 310:113-21. PMID: 1808988.
      View in: PubMed
    458. Bost KL, Clarke BL, Xu JC, Kiyono H, McGhee JR, Pascual D. Modulation of IgM secretion and H chain mRNA expression in CH12.LX.C4.5F5 B cells by adrenocorticotropic hormone. J Immunol. 1990 Dec 15; 145(12):4326-31. PMID: 2175328.
      View in: PubMed
    459. Ogawa T, Kusumoto Y, Hamada S, McGhee JR, Kiyono H. Bacteroides gingivalis-specific serum IgG and IgA subclass antibodies in periodontal diseases. Clin Exp Immunol. 1990 Nov; 82(2):318-25. PMID: 1978704.
      View in: PubMed
    460. Fujihashi K, Taguchi T, McGhee JR, Eldridge JH, Bruce MG, Green DR, Singh B, Kiyono H. Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance. J Immunol. 1990 Oct 01; 145(7):2010-9. PMID: 1975820.
      View in: PubMed
    461. Aicher WK, McGhee ML, McGhee JR, Eldridge JH, Beagley KW, Meyer TF, Kiyono H. Mouse IgA Fc receptor on CD3+ T cells. Molecular forms of IgA that bind to a 38-kDa Fc alpha R protein and development of an anti-Fc alpha R antisera. J Immunol. 1990 Sep 15; 145(6):1745-53. PMID: 2144006.
      View in: PubMed
    462. Taguchi T, McGhee JR, Coffman RL, Beagley KW, Eldridge JH, Takatsu K, Kiyono H. Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5. J Immunol. 1990 Jul 01; 145(1):68-77. PMID: 1972722.
      View in: PubMed
    463. Tarkowski A, Lue C, Moldoveanu Z, Kiyono H, McGhee JR, Mestecky J. Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses. J Immunol. 1990 May 15; 144(10):3770-8. PMID: 2110213.
      View in: PubMed
    464. Taguchi T, McGhee JR, Coffman RL, Beagley KW, Eldridge JH, Takatsu K, Kiyono H. Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J Immunol Methods. 1990 Mar 27; 128(1):65-73. PMID: 2139082.
      View in: PubMed
    465. Kiyono H, Taguchi T, Aicher WK, Beagley KW, Fujihashi K, Eldridge JH, McGhee JR. Immunoregulatory confluence: T cells, Fc receptors and cytokines for IgA immune responses. Int Rev Immunol. 1990; 6(4):263-73. PMID: 2102907.
      View in: PubMed
    466. Jirillo E, De Simone C, Covelli V, Kiyono H, McGhee JR, Antonaci S. LPS-mediated triggering of T lymphocytes in immune response against gram-negative bacteria. Adv Exp Med Biol. 1990; 256:417-25. PMID: 2183559.
      View in: PubMed
    467. Aicher WK, McGhee JR, Kiyono H. Candidates for the mouse Fc alpha R: beta-galactosyl transferase, secretory component and a 38-kDa protein. Res Immunol. 1990 Jan; 141(1):90-4; discussion 105-8. PMID: 2111919.
      View in: PubMed
    468. Char D, Aicher WK, McGhee JR, Eldridge JH, Beagley KW, Kiyono H. Induction of Fc alpha receptor expression on T cells from murine Peyer's patch, spleen and thymus. Reg Immunol. 1990-1991; 3(5):228-35. PMID: 2151788.
      View in: PubMed
    469. Fujihashi K, Kiyono H, Aicher WK, Green DR, Singh B, Eldridge JH, McGhee JR. Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance. J Immunol. 1989 Dec 01; 143(11):3415-22. PMID: 2573632.
      View in: PubMed
    470. Beagley KW, Eldridge JH, Lee F, Kiyono H, Everson MP, Koopman WJ, Hirano T, Kishimoto T, McGhee JR. Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J Exp Med. 1989 Jun 01; 169(6):2133-48. PMID: 2786548.
      View in: PubMed
    471. McGhee JR, Mestecky J, Elson CO, Kiyono H. Regulation of IgA synthesis and immune response by T cells and interleukins. J Clin Immunol. 1989 May; 9(3):175-99. PMID: 2671008.
      View in: PubMed
    472. Ogawa T, McGhee ML, Moldoveanu Z, Hamada S, Mestecky J, McGhee JR, Kiyono H. Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissues. Clin Exp Immunol. 1989 Apr; 76(1):103-10. PMID: 2567645.
      View in: PubMed
    473. McGhee ML, Ogawa T, Pitts AM, Moldoveanu Z, Mestecky J, McGhee JR, Kiyono H. Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue. Reg Immunol. 1989 Mar-Apr; 2(2):103-10. PMID: 2701813.
      View in: PubMed
    474. Ogawa T, Tarkowski A, McGhee ML, Moldoveanu Z, Mestecky J, Hirsch HZ, Koopman WJ, Hamada S, McGhee JR, Kiyono H. Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue. J Immunol. 1989 Feb 15; 142(4):1150-8. PMID: 2644350.
      View in: PubMed
    475. Beagley KW, Fujihashi K, Aicher W, Xu J, Kiyono H, Eldridge JH, Bruce MG, Taguchi T, Green DR, Singh B. Mucosal homeostasis: role of interleukins, isotype-specific factors and contrasuppression in the IgA response. Immunol Invest. 1989 Jan-May; 18(1-4):77-89. PMID: 2659524.
      View in: PubMed
    476. Tarkowski A, Lue C, Moldoveanu Z, Kiyono H, McGhee JR, Prchal JT, Halpern NB, Mestecky J. Systemic immunization for the induction of IgA responses. Curr Top Microbiol Immunol. 1989; 146:161-8. PMID: 2731429.
      View in: PubMed
    477. Beagley KW, Eldridge JH, Kiyono H, Everson MP, Koopman WJ, Honjo T, McGhee JR. Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. J Immunol. 1988 Sep 15; 141(6):2035-42. PMID: 3262647.
      View in: PubMed
    478. McGhee JR, Eldridge JH, Beagley KW, Kiyono H. The possible involvement of CD3+, CD4- and CD8- T cells in immune responses. Ann Inst Pasteur Immunol. 1988 Mar-Apr; 139(2):193-9. PMID: 3259429.
      View in: PubMed
    479. Kitamura K, Kiyono H, Fujihashi K, Eldrige JH, Beagley KW, McGhee JR. Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses. J Immunol. 1988 Mar 01; 140(5):1385-92. PMID: 2964473.
      View in: PubMed
    480. Kiyono H, Green DR, McGhee JR. Contrasuppression in the mucosal immune system. Immunol Res. 1988; 7(1):67-81. PMID: 2897412.
      View in: PubMed
    481. Beagley KW, Eldrigde JH, Kiyono H, McGhee JR. The identification of murine Peyer's patch T cell-derived factors which enhance IgA responses. Adv Exp Med Biol. 1988; 237:641-7. PMID: 3267065.
      View in: PubMed
    482. Fujihashi K, Kiyono H, Beagley KW, Eldridge JH, McGhee JR. Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation. Adv Exp Med Biol. 1988; 237:649-53. PMID: 2978205.
      View in: PubMed
    483. Kitamura K, Kiyono H, Fujihashi K, Eldridge JH, Green DR, McGhee JR. Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cells. J Immunol. 1987 Nov 15; 139(10):3251-9. PMID: 3500210.
      View in: PubMed
    484. Kimura S, Kiyono H, Beagley KW, Torii M, Eldridge JH, Hamada S, Michalek SM, Koopman WJ, McGhee JR. Streptococcal serotype carbohydrate represents a novel class of type 2 antigen which is T-independent. J Immunol. 1987 Jun 15; 138(12):4387-94. PMID: 3495591.
      View in: PubMed
    485. Kimura S, Kiyono H, Michalek SM, Hamada S, McGhee JR. Haptenated streptococcal antigens elicit either T cell-dependent type 1 or T cell-independent type 2 immune responses. Immunobiology. 1987 Mar; 174(2):146-61. PMID: 3496265.
      View in: PubMed
    486. McGhee JR, Kiyono H, Michalek SM, Mestecky J. Enteric immunization reveals a T cell network for IgA responses and suggests that humans possess a common mucosal immune system. Antonie Van Leeuwenhoek. 1987; 53(6):537-43. PMID: 3329827.
      View in: PubMed
    487. Kiyono H, McGhee JR. Mucosal T cell networks: role of Fc alpha R+ T cells and Ig BF alpha in the regulation of the IgA response. Int Rev Immunol. 1987 Jan; 2(2):157-82. PMID: 2906958.
      View in: PubMed
    488. Scicchitano R, Stanisz AM, Payan DG, Kiyono H, McGhee JR, Bienenstock J. Expression of substance P and somatostatin receptors on a T helper cell line. Adv Exp Med Biol. 1987; 216A:185-90. PMID: 2825472.
      View in: PubMed
    489. Kitamura K, Suzuki I, Kiyono H, Kurita T, Berry AK, Green DR, McGhee JR. Isotype-specific immunoregulation: T contrasuppressor cells protect IgA responses in oral tolerance. Adv Exp Med Biol. 1987; 216A:143-8. PMID: 2961203.
      View in: PubMed
    490. Eldridge JH, Kiyono H, Suzuki I, Kitamura K, Kurita T, Beagley KW, McGhee ML, Michalek SM, Green DR, McGhee JR. Regulatory T cell networks in the secretory immune system. Adv Exp Med Biol. 1987; 216A:45-55. PMID: 2961206.
      View in: PubMed
    491. Kurita T, Kiyono H, McGhee ML, McGhee JR. Isotype specific immunoregulation: role of Fc alpha R+ T cells and IBF alpha in IgA responses. Adv Exp Med Biol. 1987; 216A:81-7. PMID: 2961213.
      View in: PubMed
    492. Beagley KW, Kiyono H, Alley CD, Eldridge JH, McGhee JR. Isolation of Peyer's patch T cell subsets involved in isotype specific immunoregulation. Adv Exp Med Biol. 1987; 216A:177-83. PMID: 2825471.
      View in: PubMed
    493. Suzuki I, Kitamura K, Kiyono H, Kurita T, Green DR, McGhee JR. Isotype-specific immunoregulation. Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine Peyer's patches. J Exp Med. 1986 Aug 01; 164(2):501-16. PMID: 2941516.
      View in: PubMed
    494. Alley CD, Kiyono H, McGhee JR. Murine bone marrow IgA responses to orally administered sheep erythrocytes. J Immunol. 1986 Jun 15; 136(12):4414-9. PMID: 3519768.
      View in: PubMed
    495. Kurita T, Kiyono H, Komiyama K, Grossi CE, Mestecky J, McGhee JR. Isotype-specific immunoregulation; characterization and function of Fc receptors on T-T hybridomas which produce murine IgA-binding factor. J Immunol. 1986 Jun 01; 136(11):3953-60. PMID: 2939136.
      View in: PubMed
    496. Suzuki I, Kiyono H, Kitamura K, Green DR, McGhee JR. Abrogation of oral tolerance by contrasuppressor T cells suggests the presence of regulatory T-cell networks in the mucosal immune system. Nature. 1986 Apr 3-9; 320(6061):451-4. PMID: 3485772.
      View in: PubMed
    497. Kiyono H, Kitamura K, Kurita T, McGhee JR. T cell networks for regulation of the mucosal immune system. Ann Sclavo Collana Monogr. 1986; 3(1-2):65-76. PMID: 3322344.
      View in: PubMed
    498. Kurita T, Kiyono H, Michalek SM, McGhee JR. An enzyme-linked immunosorbent assay (ELISA) for detection of Fc alpha receptors on isotype-specific T cells. J Immunol Methods. 1985 Dec 27; 85(2):269-77. PMID: 2934484.
      View in: PubMed
    499. Antonaci S, Jirillo E, Kiyono H, Williamson SI, Michalek SM, McGhee JR. Relationship between immune system and gram-negative bacteria. III. Functional analysis of human peripheral blood lymphocyte subpopulations separated by cytoadherence with Salmonella minnesota Rb. Clin Exp Immunol. 1985 Nov; 62(2):248-55. PMID: 2935333.
      View in: PubMed
    500. Jirillo E, Antonaci S, Kiyono H, Michalek SM, McGhee JR. Relationship between immune system and gram-negative bacteria. IV. T lymphocytes from Lpsd mice possess binding site(s) for Rb Salmonella. J Immunol. 1985 Nov; 135(5):3473-8. PMID: 3876386.
      View in: PubMed
    501. Kiyono H, Mosteller-Barnum LM, Pitts AM, Williamson SI, Michalek SM, McGhee JR. Isotype-specific immunoregulation. IgA-binding factors produced by Fc alpha receptor-positive T cell hybridomas regulate IgA responses. J Exp Med. 1985 Apr 01; 161(4):731-47. PMID: 2858511.
      View in: PubMed
    502. Eldridge JH, Yaffe LJ, Ryan JJ, Kiyono H, Scher I, McGhee JR. Expression of Lyb-5 and Mls determinants by Peyer's patch B lymphocytes of X-linked immunodeficient mice. J Immunol. 1984 Nov; 133(5):2308-11. PMID: 6332843.
      View in: PubMed
    503. Kiyono H, Phillips JO, Colwell DE, Michalek SM, Koopman WJ, McGhee JR. Isotype-specificity of helper T cell clones: Fc alpha receptors regulate T and B cell collaboration for IgA responses. J Immunol. 1984 Sep; 133(3):1087-9. PMID: 6235278.
      View in: PubMed
    504. Jirillo E, Kiyono H, Michalek SM, McGhee JR. Murine immune responses to Salmonella lipopolysaccharide: oral administration of whole bacteria to C3H/HeJ mice induces secondary anti-LPS responses, especially of the IgA isotype. J Immunol. 1984 Apr; 132(4):1702-11. PMID: 6366051.
      View in: PubMed
    505. Kiyono H, Cooper MD, Kearney JF, Mosteller LM, Michalek SM, Koopman WJ, McGhee JR. Isotype specificity of helper T cell clones. Peyer's patch Th cells preferentially collaborate with mature IgA B cells for IgA responses. J Exp Med. 1984 Mar 01; 159(3):798-811. PMID: 6230414.
      View in: PubMed
    506. McGhee JR, Michalek SM, Kiyono H, Eldridge JH, Colwell DE, Williamson SI, Wannemuehler MJ, Jirillo E, Mosteller LM, Spalding DM. Mucosal immunoregulation: environmental lipopolysaccharide and GALT T lymphocytes regulate the IgA response. Microbiol Immunol. 1984; 28(3):261-80. PMID: 6234450.
      View in: PubMed
    507. McGhee JR, Kiyono H, Alley CD. Gut bacterial endotoxin: influence on gut-associated lymphoreticular tissue and host immune function. Surv Immunol Res. 1984; 3(4):241-52. PMID: 6438750.
      View in: PubMed
    508. Kiyono H, Mosteller LM, Eldridge JH, Michalek SM, McGhee JR. IgA responses in xid mice: oral antigen primes Peyer's patch cells for in vitro immune responses and secretory antibody production. J Immunol. 1983 Dec; 131(6):2616-22. PMID: 6227659.
      View in: PubMed
    509. Michalek SM, Morisaki I, Gregory RL, Kiyono H, Hamada S, McGhee JR. Oral adjuvants enhance IgA responses to Streptococcus mutans. Mol Immunol. 1983 Sep; 20(9):1009-18. PMID: 6358863.
      View in: PubMed
    510. Michalek SM, McGhee JR, Kiyono H, Colwell DE, Eldridge JH, Wannemuehler MJ, Koopman WJ. The IgA response: inductive aspects, regulatory cells, and effector functions. Ann N Y Acad Sci. 1983 Jun 30; 409:48-71. PMID: 6191614.
      View in: PubMed
    511. Eldridge JH, Kiyono H, Michalek SM, McGhee JR. Evidence for a mature B cell subpopulation in Peyer's patches of young adult xid mice. J Exp Med. 1983 Feb 01; 157(2):789-94. PMID: 6600493.
      View in: PubMed
    512. Kiyono H, Michalek SM, Mosteller LM, Torii M, Hamada S, McGhee JR. Enhancement of murine immune responses to orally administered haptenated Streptococcus mutans. Scand J Immunol. 1982 Dec; 16(6):455-63. PMID: 6186012.
      View in: PubMed
    513. Kiyono H, McGhee JR, Mosteller LM, Eldridge JH, Koopman WJ, Kearney JF, Michalek SM. Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses. J Exp Med. 1982 Oct 01; 156(4):1115-30. PMID: 6218215.
      View in: PubMed
    514. Wannemuehler MJ, Kiyono H, Babb JL, Michalek SM, McGhee JR. Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction. J Immunol. 1982 Sep; 129(3):959-65. PMID: 6980928.
      View in: PubMed
    515. Michalek SM, Kiyono H, Wannemuehler MJ, Mosteller LM, McGhee JR. Lipopolysaccharide (LPS) regulation of the immune response: LPS influence on oral tolerance induction. J Immunol. 1982 May; 128(5):1992-8. PMID: 6460815.
      View in: PubMed
    516. Kiyono H, McGhee JR, Kearney JF, Michalek SM. Enhancement of in vitro immune responses of murine Peyer's patch cultures by concanavalin A, muramyl dipeptide and lipopolysaccharide. Scand J Immunol. 1982 Apr; 15(4):329-39. PMID: 7048508.
      View in: PubMed
    517. Kiyono H, McGhee JR, Wannemuehler MJ, Michalek SM. Lack of oral tolerance in C3H/HeJ mice. J Exp Med. 1982 Feb 01; 155(2):605-10. PMID: 7035600.
      View in: PubMed
    518. Kiyono H, McGhee JR, Wannemuehler MJ, Frangakis MV, Spalding DM, Michalek SM, Koopman WJ. In vivo immune response to a T-cell-dependent antigen by cultures of disassociated murine Peyer's patch. Proc Natl Acad Sci U S A. 1982 Jan; 79(2):596-600. PMID: 6979042.
      View in: PubMed
    519. Frangakis MV, Koopman WJ, Kiyono H, Michalek SM, McGhee JR. An enzymatic method for preparation of dissociated murine Peyer's patch cells enriched for macrophages. J Immunol Methods. 1982; 48(1):33-44. PMID: 7035568.
      View in: PubMed
    520. Michalek SM, Hirasawa M, Kiyono H, Ochiai K, McGhee JR. Oral ecology and virulence of Lactobacillus casei and Streptococcus mutans in gnotobiotic rats. Infect Immun. 1981 Sep; 33(3):690-6. PMID: 6793515.
      View in: PubMed
    521. Babb JL, Kiyono H, Michalek SM, McGhee JR. LPS regulation of the immune response: suppression of immune responses to orally administered T-independent antigen. J Immunol. 1981 Sep; 127(3):1052-7. PMID: 6167615.
      View in: PubMed
    522. Hamada S, McGhee JR, Kiyono H, Michalek SM, Yokogawa K, Kawata S. Streptococcus mutans serotype g carbohydrate antigen is a B-cell mitogen. Immunol Lett. 1981 Aug; 3(3):129-32. PMID: 6974686.
      View in: PubMed
    523. Hamada S, McGhee JR, Kiyono H, Torii M, Michalek SM. Lymphoid cell responses to bacterial cell wall components: mitogenic responses of murine B cells to Streptococcus mutans carbohydrate antigens. J Immunol. 1981 Jun; 126(6):2279-83. PMID: 6262408.
      View in: PubMed
    524. Sakurai H, Tsuda K, Kiyono S, Masaki K, Kiyono H. [Studies on a new radioimmunoassay kit for glucagon (author's transl)]. Horumon To Rinsho. 1981 Feb; 29(2):271-6. PMID: 7261449.
      View in: PubMed
    525. Otake S, Hirasawa M, Brown TA, Kawabata Y, Kiyono H, Michalek SM, McGhee JR, Shiota T. Virulence of Streptococcus mutans: characterization of a serotype g antigen-defective mutants and its revertants. Infect Immun. 1981 Jan; 31(1):151-9. PMID: 6452413.
      View in: PubMed
    526. Mestecky J, McGhee JR, Crago SS, Jackson S, Kilian M, Kiyono H, Babb JL, Michalek SM. Molecular-cellular interactions in the secretory IgA response. J Reticuloendothel Soc. 1980 Dec; 28(Suppl):45s-60s. PMID: 7003139.
      View in: PubMed
    527. Michalek SM, Kiyono H, Babb JL, McGhee JR. Inheritance of LPS nonresponsiveness and elevated splenic IgA immune responses in mice orally immunized with heterologous erythrocytes. J Immunol. 1980 Nov; 125(5):2220-4. PMID: 7430625.
      View in: PubMed
    528. Kiyono H, Babb JL, Michalek SM, McGhee JR. Cellular basis for elevated IgA responses in C3H/HeJ mice. J Immunol. 1980 Aug; 125(2):732-7. PMID: 6967087.
      View in: PubMed
    529. McGhee JR, Kiyono H, Michalek SM, Babb JL, Rosenstreich DL, Mergenhagen SE. Lipopolysaccharide (LPS) regulation of the immune response: T lymphocytes from normal mice suppress mitogenic and immunogenic responses to LPS. J Immunol. 1980 Apr; 124(4):1603-11. PMID: 6965952.
      View in: PubMed
    530. Hirasawa M, Kiyono H, Babb JL, Shiota T, Michalek SM, McGhee JR. Virulence of Streptococcus mutans: in vivo reversion of a low-virulence mutant results in partial displacement and pathogenesis. Infect Immun. 1980 Mar; 27(3):1003-11. PMID: 6445879.
      View in: PubMed
    531. Hirasawa M, Kiyono H, Shiota T, Hull RA, Curtiss R, Michalek SM, McGhee JR. Virulence of Streptococcus mutans: restoration of pathogenesis of a glucosyltransferase-defective mutant (C4). Infect Immun. 1980 Mar; 27(3):915-21. PMID: 6445880.
      View in: PubMed
    532. Hirasawa M, Kiyono H, Shiota T, Michalek SM, McGhee JR. Virulence of Streptococcus mutans: immunochemical characterization of a serotype g-defective mutant (C307). Infect Immun. 1980 Feb; 27(2):697-9. PMID: 7380547.
      View in: PubMed
    533. Kiyono H, McGhee JR, Michalek SM. Lipopolysaccharide regulation of the immune response: comparison of responses to LPS in germfree, Escherichia coli-monoassociated and conventional mice. J Immunol. 1980 Jan; 124(1):36-41. PMID: 6985644.
      View in: PubMed
    534. Otake S, McGhee JR, Hirasawa M, Williams K, Arnold RR, Babb JL, Kiyono H, Cox C, Michalek SM, Shiota T, Ikeda T, Ochiai K. Use of mutants in the elucidation of virulence of Streptococcus mutans. Adv Exp Med Biol. 1978; 107:673-83. PMID: 742506.
      View in: PubMed
    535. Taminato A, Goto Y, Miyamoto Y, Ikeda M, Kiyono H. [Proceedings: Dynamics of insulin secretion in various diseases, with special reference to a comparison of insulin response to stimulation by glucose, arginine and glucagon]. Nihon Naibunpi Gakkai Zasshi. 1974 Feb 20; 50(2):220. PMID: 4476358.
      View in: PubMed
    536. Kurahachi H, Sakurai H, Yoshimi T, Fukase M, Kiyono H. [Proceedings: Effect of glucocorticoids on glucagon secretion]. Nihon Naibunpi Gakkai Zasshi. 1974 Feb 20; 50(2):251. PMID: 4476377.
      View in: PubMed
    537. Kiyono H, Goto Y, Taminato T, Kurahachi H, Sakurai H. [Proceedings: Pancreatic glucagon response in the arginine stimulation test in endocrine diseases]. Nihon Naibunpi Gakkai Zasshi. 1974 Feb 20; 50(2):248. PMID: 4476374.
      View in: PubMed
    538. Imura H, Kiyono H, Miyamato Y, Goto Y, Sakurai H. [Insulin resistant diabetes]. Nihon Rinsho. 1973 Jul; 31(7):2260-6. PMID: 4795324.
      View in: PubMed