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    Hiroshi Kiyono

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0063
    CA La Jolla 92093
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      Collapse Bibliographic 
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. J Clin Invest. 2017 Sep 11. PMID: 28891812.
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      2. Azegami T, Yuki Y, Hayashi K, Hishikawa A, Sawada SI, Ishige K, Akiyoshi K, Kiyono H, Itoh H. Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents. J Hypertens. 2017 Aug 21. PMID: 28832363.
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      3. Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. IL-22 induces Reg3? and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017 Aug 15. PMID: 28811323.
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      4. Takahashi Y, Sato S, Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T, Kiyono H. Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells. EBioMedicine. 2017 Aug 02. PMID: 28789943.
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      5. Ogawa T, Kashima K, Yuki Y, Mejima M, Kurokawa S, Kuroda M, Okazawa A, Kiyono H, Ohta D. Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit. Sci Rep. 2017 Jul 12; 7(1):5196. PMID: 28701756.
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      6. Kim SH, Cho BH, Kiyono H, Jang YS. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches. Sci Rep. 2017 Jun 21; 7(1):3980. PMID: 28638068.
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      7. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med. 2017 Jun 05; 214(6):1607-1618. PMID: 28512157.
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      8. Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H. Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Immunity. 2017 May 16; 46(5):863-874.e4. PMID: 28514691.
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      9. Park EJ, Shimaoka M, Kiyono H. MicroRNA-mediated dynamic control of mucosal immunity. Int Immunol. 2017 Apr 01; 29(4):157-163. PMID: 28383678.
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      10. Nakajima-Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, Murakami H, Hosono A, Nochi T, Wakatsuki Y, Shimojo N, Kaminogawa S, Sato R, Kiyono H, Hachimura S. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy. PLoS One. 2017; 12(2):e0172795. PMID: 28234975.
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      11. Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H. Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nat Commun. 2017 Feb 22; 8:14509. PMID: 28224999.
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      12. Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One. 2017; 12(2):e0172509. PMID: 28225814.
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      13. Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R. The spleen is the site where mast cells are induced in the development of food allergy. Int Immunol. 2017 Feb 08. PMID: 28177443.
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      14. Tada R, Muto S, Iwata T, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y. Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice. BMC Res Notes. 2017 Jan 26; 10(1):68. PMID: 28126014.
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      15. Azegami T, Yuki Y, Sawada S, Mejima M, Ishige K, Akiyoshi K, Itoh H, Kiyono H. Nanogel-based nasal ghrelin vaccine prevents obesity. Mucosal Immunol. 2017 Jan 25. PMID: 28120848.
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      16. Kurashima Y, Kiyono H. Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. Annu Rev Immunol. 2017 Jan 11. PMID: 28125357.
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      17. Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF, Kiyono H. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunol. 2016 Dec 07. PMID: 27924821.
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      18. Nelson S, Kiyono H, Kurashima Y. Epithelial extracellular ATP: an initiator of immunity to parasitic infections. Immunol Cell Biol. 2017 Feb; 95(2):117-118. PMID: 27874014.
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      19. Goto Y, Uematsu S, Kiyono H. Epithelial glycosylation in gut homeostasis and inflammation. Nat Immunol. 2016 Oct 19; 17(11):1244-1251. PMID: 27760104.
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      20. Lee J, Park EJ, Kiyono H. MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation. BMB Rep. 2016 May; 49(5):263-9. PMID: 26923304.
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      21. Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CG, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF. Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism. Immunity. 2016 Mar 15; 44(3):634-46. PMID: 26982365; NIHMSID: NIHMS763185 [Available on 03/15/17].
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      22. Kogure Y, Kurashima Y, Kiyono H. [MAST CELL MEDIATED HOMEOSTATIC AND BARRIER SYSTEM]. Arerugi. 2016 Mar; 65(2):104-12. PMID: 27086955.
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      23. Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H. Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. Regul Toxicol Pharmacol. 2016 Apr; 76:128-36. PMID: 26851506.
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      24. Kunisawa J, Kiyono H. Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy. Front Nutr. 2016; 3:3. PMID: 26858949; PMCID: PMC4728802.
      25. Saito S, Ainai A, Suzuki T, Harada N, Ami Y, Yuki Y, Takeyama H, Kiyono H, Tsukada H, Hasegawa H. The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine. Vaccine. 2016 Feb 24; 34(9):1201-7. PMID: 26802605.
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      26. Kashima K, Yuki Y, Mejima M, Kurokawa S, Suzuki Y, Minakawa S, Takeyama N, Fukuyama Y, Azegami T, Tanimoto T, Kuroda M, Tamura M, Gomi Y, Kiyono H. Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants. Plant Cell Rep. 2016 Mar; 35(3):667-79. PMID: 26661780.
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      27. Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis. Sci Rep. 2015 Dec 09; 5:18174. PMID: 26647826; PMCID: PMC4673535.
      28. Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages. PLoS One. 2015; 10(11):e0142920. PMID: 26575399; PMCID: PMC4648567.
      29. Goto Y, Lamichhane A, Kamioka M, Sato S, Honda K, Kunisawa J, Kiyono H. IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut. Sci Rep. 2015; 5:15918. PMID: 26522513; PMCID: PMC4629126.
      30. Tada R, Hidaka A, Iwase N, Takahashi S, Yamakita Y, Iwata T, Muto S, Sato E, Takayama N, Honjo E, Kiyono H, Kunisawa J, Aramaki Y. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice. PLoS One. 2015; 10(10):e0139785. PMID: 26440657; PMCID: PMC4594917.
      31. Goto Y, Kurashima Y, Kiyono H. [Roles of the gut mucosal immune system in symbiosis and immunity]. Rinsho Ketsueki. 2015 Oct; 56(10):2205-12. PMID: 26458461.
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      32. Fukuyama Y, Okada K, Yamaguchi M, Kiyono H, Mori K, Yuki Y. Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice. PLoS One. 2015; 10(9):e0139368. PMID: 26422280; PMCID: PMC4589288.
      33. Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M, Kiyono H. Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1. Cell Rep. 2015 Oct 6; 13(1):122-31. PMID: 26411688.
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      34. Takeyama N, Kiyono H, Yuki Y. Plant-based vaccines for animals and humans: recent advances in technology and clinical trials. Ther Adv Vaccines. 2015 Sep; 3(5-6):139-54. PMID: 26668752.
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      35. Takeyama N, Yuki Y, Tokuhara D, Oroku K, Mejima M, Kurokawa S, Kuroda M, Kodama T, Nagai S, Ueda S, Kiyono H. Oral rice-based vaccine induces passive and active immunity against enterotoxigenic E. coli-mediated diarrhea in pigs. Vaccine. 2015 Sep 22; 33(39):5204-11. PMID: 26254309.
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      36. Park EJ, Yuki Y, Kiyono H, Shimaoka M. Structural basis of blocking integrin activation and deactivation for anti-inflammation. J Biomed Sci. 2015; 22:51. PMID: 26152212; PMCID: PMC4495637.
      37. Goto Y, Kurashima Y, Kiyono H. The gut microbiota and inflammatory bowel disease. Curr Opin Rheumatol. 2015 Jul; 27(4):388-96. PMID: 26002031.
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      38. Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. Dietary ?3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep. 2015; 5:9750. PMID: 26065911; PMCID: PMC4464255.
      39. Suzuki H, Watari A, Hashimoto E, Yonemitsu M, Kiyono H, Yagi K, Kondoh M, Kunisawa J. C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine. PLoS One. 2015; 10(5):e0126352. PMID: 26018248; PMCID: PMC4446347.
      40. Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H. Central Role of Core Binding Factor ß2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. PLoS One. 2015; 10(5):e0127460. PMID: 26001080; PMCID: PMC4441428.
      41. Kurashima Y, Kiyono H, Kunisawa J. Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation. Mediators Inflamm. 2015; 2015:427125. PMID: 25944982; PMCID: PMC4405224.
      42. Kishida K, Kohyama M, Kurashima Y, Kogure Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H. Negative regulation of DSS-induced experimental colitis by PILRa. Int Immunol. 2015 Jun; 27(6):307-14. PMID: 25710489.
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      43. Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K. The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015 Feb 17; 42(2):279-93. PMID: 25692702.
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      44. Fukuyama Y, Yuki Y, Katakai Y, Harada N, Takahashi H, Takeda S, Mejima M, Joo S, Kurokawa S, Sawada S, Shibata H, Park EJ, Fujihashi K, Briles DE, Yasutomi Y, Tsukada H, Akiyoshi K, Kiyono H. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunol. 2015 Sep; 8(5):1144-53. PMID: 25669148; PMCID: PMC4762909.
      45. Kashima K, Mejima M, Kurokawa S, Kuroda M, Kiyono H, Yuki Y. Comparative whole-genome analyses of selection marker-free rice-based cholera toxin B-subunit vaccine lines and wild-type lines. BMC Genomics. 2015; 16:48. PMID: 25653106; PMCID: PMC4320824.
      46. Kunisawa J, Kiyono H. Vitamins mediate immunological homeostasis and diseases at the surface of the body. Endocr Metab Immune Disord Drug Targets. 2015; 15(1):25-30. PMID: 25335990.
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      47. Kiyono H, Azegami T. The mucosal immune system: From dentistry to vaccine development. Proc Jpn Acad Ser B Phys Biol Sci. 2015; 91(8):423-39. PMID: 26460320; PMCID: PMC4729857.
      48. Sato S, Kiyono H, Fujihashi K. Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review. Gerontology. 2015; 61(4):336-42. PMID: 25531743; NIHMSID: NIHMS641158.
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      49. Kurashima Y, Kiyono H, Kunisawa J. [Purinergic signaling mediates mast cell activation in intestinal inflammation]. Seikagaku. 2014 Dec; 86(6):798-802. PMID: 25675821.
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      50. Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K. Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease. J Immunol. 2015 Jan 1; 194(1):398-406. PMID: 25422510.
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      51. Nakajima-Adachi H, Kikuchi A, Fujimura Y, Shibahara K, Makino T, Goseki-Sone M, Kihara-Fujioka M, Nochi T, Kurashima Y, Igarashi O, Yamamoto M, Kunisawa J, Toda M, Kaminogawa S, Sato R, Kiyono H, Hachimura S. Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy. PLoS One. 2014; 9(10):e107492. PMID: 25290461; PMCID: PMC4188560.
      52. Okura H, Sato S, Kishikawa S, Kaneto S, Nakashima T, Yoshida N, Takayanagi H, Kiyono H. Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. PLoS One. 2014; 9(9):e108294. PMID: 25244033; PMCID: PMC4171521.
      53. Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H. Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol. 2014 Dec; 88(23):13699-708. PMID: 25231301; PMCID: PMC4248987.
      54. Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science. 2014 Sep 12; 345(6202):1254009. PMID: 25214634; NIHMSID: NIHMS760966.
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      55. Azegami T, Itoh H, Kiyono H, Yuki Y. Novel transgenic rice-based vaccines. Arch Immunol Ther Exp (Warsz). 2015 Apr; 63(2):87-99. PMID: 25027548.
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      56. Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H. Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. J Immunol. 2014 Aug 15; 193(4):1666-71. PMID: 25031459.
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      57. Azegami T, Yuki Y, Kiyono H. Challenges in mucosal vaccines for the control of infectious diseases. Int Immunol. 2014 Sep; 26(9):517-28. PMID: 24914172.
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      58. Tokuhara D, Nochi T, Matsumura A, Mejima M, Takahashi Y, Kurokawa S, Kiyono H, Yuki Y. Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine. Dig Dis Sci. 2014 Nov; 59(11):2682-92. PMID: 24838500.
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      59. Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T. Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice. Inflamm Bowel Dis. 2014 May; 20(5):790-9. PMID: 24651581.
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      60. Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 2014; 5:3704. PMID: 24718324.
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      61. Kurashima Y, Amiya T, Fujisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. Immunity. 2014 Apr 17; 40(4):530-41. PMID: 24726878.
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      62. Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 2014; 5:3492. PMID: 24637670; PMCID: PMC3959210.
      63. Kurashima Y, Kiyono H. New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development. Exp Mol Med. 2014; 46:e83. PMID: 24626169; PMCID: PMC3972796.
      64. Kotani Y, Kunisawa J, Suzuki Y, Sato I, Saito T, Toba M, Kohda N, Kiyono H. Role of Lactobacillus pentosus Strain b240 and the Toll-like receptor 2 axis in Peyer's patch dendritic cell-mediated immunoglobulin A enhancement. PLoS One. 2014; 9(3):e91857. PMID: 24632732; PMCID: PMC3954862.
      65. Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H. A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. J Biotechnol. 2014 Apr 10; 175:45-52. PMID: 24548461.
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      66. Fujihashi K, Sato S, Kiyono H. Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. Exp Gerontol. 2014 Jun; 54:21-6. PMID: 24440991; NIHMSID: NIHMS567146.
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      67. Suzuki H, Kondoh M, Yagi K, Kiyono H, Kunisawa J. [The development of mucosal vaccine using bacterial function for targeting mucosal tissues]. Yakugaku Zasshi. 2014; 134(5):629-34. PMID: 24790045.
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      68. Korneychuk N, Ramiro-Puig E, Ettersperger J, Schulthess J, Montcuquet N, Kiyono H, Meresse B, Cerf-Bensussan N. Interleukin 15 and CD4? T cells cooperate to promote small intestinal enteropathy in response to dietary antigen. Gastroenterology. 2014 Apr; 146(4):1017-27. PMID: 24361466.
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      69. Lamichhane A, Kiyono H, Kunisawa J. Nutritional components regulate the gut immune system and its association with intestinal immune disease development. J Gastroenterol Hepatol. 2013 Dec; 28 Suppl 4:18-24. PMID: 24251698.
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      70. Kurashima Y, Goto Y, Kiyono H. Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur J Immunol. 2013 Dec; 43(12):3108-15. PMID: 24414823.
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      71. Kishino S, Takeuchi M, Park SB, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17808-13. PMID: 24127592; PMCID: PMC3816446.
      72. Kurokawa S, Kuroda M, Mejima M, Nakamura R, Takahashi Y, Sagara H, Takeyama N, Satoh S, Kiyono H, Teshima R, Masumura T, Yuki Y. RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds. Plant Cell Rep. 2014 Jan; 33(1):75-87. PMID: 24085308.
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      73. Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. PLoS One. 2013; 8(8):e72050. PMID: 23951282; PMCID: PMC3741198.
      74. Tokuhara D, Álvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, Kuroda M, Oyama M, Kozuka-Hata H, Nochi T, Sagara H, Aladin F, Marcotte H, Frenken LG, Iturriza-Gómara M, Kiyono H, Hammarström L, Yuki Y. Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest. 2013 Sep; 123(9):3829-38. PMID: 23925294; PMCID: PMC3754275.
      75. Kunisawa J, Kiyono H. Vitamin-mediated regulation of intestinal immunity. Front Immunol. 2013; 4:189. PMID: 23874335; PMCID: PMC3708512.
      76. Kurokawa S, Nakamura R, Mejima M, Kozuka-Hata H, Kuroda M, Takeyama N, Oyama M, Satoh S, Kiyono H, Masumura T, Teshima R, Yuki Y. MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of a-amylase/trypsin inhibitor-like protein family as major rice allergens. J Proteome Res. 2013 Jul 5; 12(7):3372-82. PMID: 23763241.
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      77. Obata T, Shibata N, Goto Y, Ishikawa I, Sato S, Kunisawa J, Kiyono H. Critical role of dendritic cells in T cell retention in the interfollicular region of Peyer's patches. J Immunol. 2013 Jul 15; 191(2):942-8. PMID: 23772027.
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      78. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Takahashi Y, Tokuhara D, Nochi T, Katakai Y, Kuroda M, Takeyama N, Kashima K, Abe M, Chen Y, Nakanishi U, Masumura T, Takeuchi Y, Kozuka-Hata H, Shibata H, Oyama M, Tanaka K, Kiyono H. Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol J. 2013 Sep; 11(7):799-808. PMID: 23601492.
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      79. Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert RS, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee JR, Fujihashi K. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One. 2013; 8(4):e60453. PMID: 23565250; PMCID: PMC3615010.
      80. Kong IG, Sato A, Yuki Y, Nochi T, Takahashi H, Sawada S, Mejima M, Kurokawa S, Okada K, Sato S, Briles DE, Kunisawa J, Inoue Y, Yamamoto M, Akiyoshi K, Kiyono H. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun. 2013 May; 81(5):1625-34. PMID: 23460513; PMCID: PMC3647999.
      81. Kunisawa J, Gohda M, Hashimoto E, Ishikawa I, Higuchi M, Suzuki Y, Goto Y, Panea C, Ivanov II, Sumiya R, Aayam L, Wake T, Tajiri S, Kurashima Y, Shikata S, Akira S, Takeda K, Kiyono H. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun. 2013; 4:1772. PMID: 23612313; PMCID: PMC3644083.
      82. Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun. 2013; 4:1949. PMID: 23752491.
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      84. Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K. Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol. 2013 Jan 15; 190(2):774-83. PMID: 23241884; PMCID: PMC3539688.
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      86. Nakajima-Adachi H, Koike E, Totsuka M, Hiraide E, Wakatsuki Y, Kiyono H, Hachimura S. Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4?T cells into the Th2 or Th1 phenotype. Biosci Biotechnol Biochem. 2012; 76(10):1979-81. PMID: 23047087.
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      87. Kumagai T, Kiyono H. Summary for symposium I on the development of a more efficacious influenza vaccine held at the 15th Annual Meeting of the Japanese Society for Vaccinology, Tokyo, 2011. Vaccine. 2012 Sep 28; 30(44):6338-9. PMID: 22906723.
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      88. Kunisawa J, Kiyono H. Immune regulation and monitoring at the epithelial surface of the intestine. Drug Discov Today. 2013 Jan; 18(1-2):87-92. PMID: 22897879.
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      89. Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K. Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol. 2012 Sep 15; 189(6):2869-78. PMID: 22869901.
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      90. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K. PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 2012 Oct; 24(10):613-23. PMID: 22836022.
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      91. Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 2012 Jun 8; 336(6086):1321-5. PMID: 22674331; NIHMSID: NIHMS469304.
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      92. Jeon SG, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, Tsuji NM, Kiyono H, Ma JS, Kusu T, Okumura R, Hara H, Yoshida H, Yamamoto M, Nomoto K, Takeda K. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog. 2012; 8(5):e1002714. PMID: 22693446; PMCID: PMC3364948.
      93. Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice. J Immunol. 2012 Jun 15; 188(12):6145-55. PMID: 22611244; NIHMSID: NIHMS372247.
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      94. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Kong IG, Kuroda M, Takahashi Y, Nochi T, Tokuhara D, Kohda T, Kozaki S, Kiyono H. RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine. Vaccine. 2012 Jun 13; 30(28):4160-6. PMID: 22554467.
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      95. Sato S, Kiyono H. The mucosal immune system of the respiratory tract. Curr Opin Virol. 2012 Jun; 2(3):225-32. PMID: 22542216.
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      96. Kunisawa J, Kiyono H. Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses. Front Immunol. 2012; 3:65. PMID: 22566946; PMCID: PMC3342267.
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      98. Fujkuyama Y, Tokuhara D, Kataoka K, Gilbert RS, McGhee JR, Yuki Y, Kiyono H, Fujihashi K. Novel vaccine development strategies for inducing mucosal immunity. Expert Rev Vaccines. 2012 Mar; 11(3):367-79. PMID: 22380827; NIHMSID: NIHMS364849.
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      99. Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 2012; 7(2):e32094. PMID: 22363800; PMCID: PMC3282783.
      100. Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood. 2012 Mar 22; 119(12):2768-77. PMID: 22279057; PMCID: PMC3327455.
      101. Kim DY, Fukuyama S, Nagatake T, Takamura K, Kong IG, Yokota Y, Lee CH, Kiyono H. Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model. Allergy. 2012 Apr; 67(4):502-9. PMID: 22257110.
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      102. Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun. 2012; 3:1034. PMID: 22948816; PMCID: PMC3658010.
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      104. Goto Y, Kiyono H. Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol Rev. 2012 Jan; 245(1):147-63. PMID: 22168418.
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      106. Kim SH, Jung DI, Yang IY, Kim J, Lee KY, Nochi T, Kiyono H, Jang YS. M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery. Eur J Immunol. 2011 Nov; 41(11):3219-29. PMID: 21887786.
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      107. Takeyama N, Yuki Y, Kiyono H. [Current progress in the development of mucosal vaccines]. Nihon Rinsho. 2011 Sep; 69(9):1555-60. PMID: 21922752.
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      108. Okada K, Yamasoba T, Kiyono H. Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine. Adv Otorhinolaryngol. 2011; 72:31-6. PMID: 21865684.
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      109. Stappenbeck T, Kiyono H. Host pathogens. Editorial overview. Curr Opin Immunol. 2011 Aug; 23(4):445-7. PMID: 21856138.
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      110. Kunisawa J, Kurashima Y, Kiyono H. Gut-associated lymphoid tissues for the development of oral vaccines. Adv Drug Deliv Rev. 2012 May 1; 64(6):523-30. PMID: 21827802.
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      111. Burggraf M, Nakajima-Adachi H, Hachimura S, Ilchmann A, Pemberton AD, Kiyono H, Vieths S, Toda M. Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy. Mol Nutr Food Res. 2011 Oct; 55(10):1475-83. PMID: 21714123.
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      112. Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011 May 19; 9(5):376-89. PMID: 21575909.
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      113. Goto Y, Kiyono H. Epithelial cell microRNAs in gut immunity. Nat Immunol. 2011 Mar; 12(3):195-7. PMID: 21321589.
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      114. Kim DY, Sato A, Fukuyama S, Sagara H, Nagatake T, Kong IG, Goda K, Nochi T, Kunisawa J, Sato S, Yokota Y, Lee CH, Kiyono H. The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J Immunol. 2011 Apr 1; 186(7):4253-62. PMID: 21357262.
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      115. Kunisawa J, Kiyono H. Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. Cell Host Microbe. 2011 Feb 17; 9(2):83-4. PMID: 21320688.
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      116. Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H. Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun. 2011 Jan 21; 404(3):822-8. PMID: 21172308.
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      117. Takahashi I, Fujihashi K, Kiyono H. Mucosal regulatory cells in the gastrointestinal tract and periodontium. Periodontol 2000. 2010 Oct; 54(1):247-56. PMID: 20712644.
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      118. Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010 Dec; 84(24):12703-12. PMID: 20881038; PMCID: PMC3004317.
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      120. Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K. High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. J Biol Chem. 2010 Oct 1; 285(40):30427-35. PMID: 20663890; PMCID: PMC2945535.
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      122. Malamut G, El Machhour R, Montcuquet N, Martin-Lannerée S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest. 2010 Jun; 120(6):2131-43. PMID: 20440074; PMCID: PMC2877946.
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      124. Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H. Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8794-9. PMID: 20421480; PMCID: PMC2889329.
      125. Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7419-24. PMID: 20360558; PMCID: PMC2867693.
      126. Fuglem B, Jirillo E, Bjerkås I, Kiyono H, Nochi T, Yuki Y, Raida M, Fischer U, Koppang EO. Antigen-sampling cells in the salmonid intestinal epithelium. Dev Comp Immunol. 2010 Jul; 34(7):768-74. PMID: 20178814.
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      127. Umehara T, Udagawa J, Takamura K, Kimura M, Ishimitsu R, Kiyono H, Kawauchi H, Otani H. Role of interleukin-15 in the development of mouse olfactory nerve. Congenit Anom (Kyoto). 2009 Dec; 49(4):253-7. PMID: 20021484.
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      128. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 2009 Nov 12; 462(7270):226-30. PMID: 19907495.
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      129. Sato A, Kiyono H. [The mucosal immune system: new strategy for the control of allergic diseases]. Nihon Rinsho. 2009 Nov; 67(11):2194-9. PMID: 19899540.
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      130. Nochi T, Yuki Y, Katakai Y, Shibata H, Tokuhara D, Mejima M, Kurokawa S, Takahashi Y, Nakanishi U, Ono F, Mimuro H, Sasakawa C, Takaiwa F, Terao K, Kiyono H. A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity. J Immunol. 2009 Nov 15; 183(10):6538-44. PMID: 19880451.
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      131. Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR. RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J Immunol. 2009 Nov 1; 183(9):5738-47. PMID: 19828638; NIHMSID: NIHMS220616.
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      132. Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 2009 Oct 26; 206(11):2351-64. PMID: 19822644; PMCID: PMC2768868.
      133. Suzuki R, Nourani MR, Saino-Saito S, Abe H, Nochi T, Kiyono H, Spener F, Kondo H, Owada Y. Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine. Histochem Cell Biol. 2009 Dec; 132(6):577-84. PMID: 19787366.
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      134. Mavichak R, Takano T, Kondo H, Hirono I, Wada S, Hatai K, Inagawa H, Takahashi Y, Yoshimura T, Kiyono H, Yuki Y, Aoki T. The effect of liposome-coated recombinant protein VP28 against white spot syndrome virus in kuruma shrimp, Marsupenaeus japonicus. J Fish Dis. 2010 Jan; 33(1):69-74. PMID: 19735346.
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      135. Yuki Y, Tokuhara D, Nochi T, Yasuda H, Mejima M, Kurokawa S, Takahashi Y, Kataoka N, Nakanishi U, Hagiwara Y, Fujihashi K, Takaiwa F, Kiyono H. Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine. 2009 Oct 9; 27(43):5982-8. PMID: 19665603.
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      136. Yuki Y, Kiyono H. Mucosal vaccines: novel advances in technology and delivery. Expert Rev Vaccines. 2009 Aug; 8(8):1083-97. PMID: 19627189.
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      137. Fujihashi K, Kiyono H. Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends Immunol. 2009 Jul; 30(7):334-43. PMID: 19540811.
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      138. Takahashi I, Nochi T, Yuki Y, Kiyono H. New horizon of mucosal immunity and vaccines. Curr Opin Immunol. 2009 Jun; 21(3):352-8. PMID: 19493665.
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      139. Nochi T, Kiyono H. [Recent progress for the development of mucosal vaccine]. Tanpakushitsu Kakusan Koso. 2009 Jun; 54(8 Suppl):1089-95. PMID: 21089546.
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      140. Kim D, Kim SH, Park EJ, Kim J, Cho SH, Kagawa J, Arai N, Jun K, Kiyono H, Kim S. Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta. Int Arch Allergy Immunol. 2009; 150(2):164-71. PMID: 19439982.
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      141. Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun. 2009 Jun 5; 383(3):340-6. PMID: 19358828.
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      142. Kunisawa J, Nochi T, Kiyono H. Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol. 2008 Nov; 29(11):505-13. PMID: 18835748.
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      143. Fehervari Z, Kiyono H. The mucosa: at the frontlines of immunity. Trends Immunol. 2008 Nov; 29(11):503-4. PMID: 18838300.
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      144. Mestecky J, Nguyen H, Czerkinsky C, Kiyono H. Oral immunization: an update. Curr Opin Gastroenterol. 2008 Nov; 24(6):713-9. PMID: 19122521.
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      145. Yuki Y, Kiyono H. [MucoRice: development of rice-based oral vaccine]. Nihon Rinsho Meneki Gakkai Kaishi. 2008 Oct; 31(5):369-74. PMID: 18974620.
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      146. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 2008 Jun 15; 180(12):7840-6. PMID: 18523247.
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      147. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 2008 Jul; 9(7):769-76. PMID: 18516037.
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      148. Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice. Int Immunol. 2008 Jul; 20(7):881-91. PMID: 18492657.
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      149. Ooi EL, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol. 2008; 32(10):1211-20. PMID: 18466972.
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      150. Caipang CM, Verjan N, Ooi EL, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis. Fish Shellfish Immunol. 2008 Sep; 25(3):315-20. PMID: 18603448.
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      151. Verjan N, Ooi EL, Nochi T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2008 Jul; 25(1-2):170-80. PMID: 18499475.
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      152. Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol. 2008 Apr 15; 180(8):5335-43. PMID: 18390715.
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      153. Momoi F, Hashizume T, Kurita-Ochiai T, Yuki Y, Kiyono H, Yamamoto M. Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies. Infect Immun. 2008 Jun; 76(6):2777-84. PMID: 18411288; PMCID: PMC2423079.
      154. Chang SY, Cha HR, Igarashi O, Rennert PD, Kissenpfennig A, Malissen B, Nanno M, Kiyono H, Kweon MN. Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. J Immunol. 2008 Apr 1; 180(7):4361-5. PMID: 18354155.
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      155. Kunisawa J, Gohda M, Kurashima Y, Ishikawa I, Higuchi M, Kiyono H. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. Blood. 2008 May 1; 111(9):4646-52. PMID: 18292290.
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      156. Kurashima Y, Kunisawa J, Kiyono H. [Applicable strategies for the mucosal immune system in the regulation of allergic diseases]. Arerugi. 2008 Feb; 57(2):87-94. PMID: 18349582.
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      157. Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol. 2008 Feb 1; 180(3):1609-18. PMID: 18209057.
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      158. Brandtzaeg P, Kiyono H, Pabst R, Russell MW. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol. 2008 Jan; 1(1):31-7. PMID: 19079158.
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      159. Hashizume T, Togawa A, Nochi T, Igarashi O, Kweon MN, Kiyono H, Yamamoto M. Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp. Infect Immun. 2008 Mar; 76(3):927-34. PMID: 18086815; PMCID: PMC2258839.
      160. Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, Kim DY, Fukuyama S, Iwatsuki-Horimoto K, Kawaoka Y, Kohda T, Kozaki S, Igarashi O, Kiyono H. A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med. 2007 Nov 26; 204(12):2789-96. PMID: 17984304; PMCID: PMC2118513.
      161. Takamura K, Fukuyama S, Nagatake T, Kim DY, Kawamura A, Kawauchi H, Kiyono H. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 2007 Nov 1; 179(9):5897-906. PMID: 17947663.
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      162. Ooi EL, Verjan N, Hirono I, Nochi T, Kondo H, Aoki T, Kiyono H, Yuki Y. Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli. Fish Shellfish Immunol. 2008 May; 24(5):506-13. PMID: 18329900.
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      163. Kunisawa J, Kurashima Y, Higuchi M, Gohda M, Ishikawa I, Ogahara I, Kim N, Shimizu M, Kiyono H. Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med. 2007 Oct 1; 204(10):2335-48. PMID: 17875673; PMCID: PMC2118459.
      164. Kurashima Y, Kunisawa J, Higuchi M, Gohda M, Ishikawa I, Takayama N, Shimizu M, Kiyono H. Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. J Immunol. 2007 Aug 1; 179(3):1577-85. PMID: 17641024.
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      165. Yuki Y, Nochi T, Kiyono H. Progress towards an AIDS mucosal vaccine: an overview. Tuberculosis (Edinb). 2007 Aug; 87 Suppl 1:S35-44. PMID: 17652028.
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      166. Nochi T, Takagi H, Yuki Y, Yang L, Masumura T, Mejima M, Nakanishi U, Matsumura A, Uozumi A, Hiroi T, Morita S, Tanaka K, Takaiwa F, Kiyono H. Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10986-91. PMID: 17573530; PMCID: PMC1904174.
      167. Ohka S, Igarashi H, Nagata N, Sakai M, Koike S, Nochi T, Kiyono H, Nomoto A. Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. J Virol. 2007 Aug; 81(15):7902-12. PMID: 17507470; PMCID: PMC1951287.
      168. Nagai S, Mimuro H, Yamada T, Baba Y, Moro K, Nochi T, Kiyono H, Suzuki T, Sasakawa C, Koyasu S. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8971-6. PMID: 17502608; PMCID: PMC1885612.
      169. Tamagawa H, Hiroi T, Mizushima T, Ito T, Matsuda H, Kiyono H. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis. Inflamm Bowel Dis. 2007 May; 13(5):547-56. PMID: 17245768.
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      170. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007 Apr 15; 178(8):4937-46. PMID: 17404275.
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      171. Fukuyama S, Kiyono H. Neuroregulator RET initiates Peyer's-patch tissue genesis. Immunity. 2007 Apr; 26(4):393-5. PMID: 17459808.
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      172. Takayama N, Igarashi O, Kweon MN, Kiyono H. Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea. Clin Immunol. 2007 May; 123(2):199-208. PMID: 17360239.
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      173. McGhee JR, Kunisawa J, Kiyono H. Gut lymphocyte migration: we are halfway 'home'. Trends Immunol. 2007 Apr; 28(4):150-3. PMID: 17293162.
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      174. Kunisawa J, Takahashi I, Kiyono H. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev. 2007 Feb; 215:136-53. PMID: 17291285.
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      175. Kunisawa J, Gohda M, Kiyono H. [Uniqueness of the mucosal immune system for the development of prospective mucosal vaccine]. Yakugaku Zasshi. 2007 Feb; 127(2):319-26. PMID: 17268152.
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      176. Kunisawa J, Kurashima Y, Gohda M, Higuchi M, Ishikawa I, Miura F, Ogahara I, Kiyono H. Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. Blood. 2007 May 1; 109(9):3749-56. PMID: 17234743.
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      177. Kim N, Kunisawa J, Kweon MN, Eog Ji G, Kiyono H. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin Immunol. 2007 Apr; 123(1):30-9. PMID: 17218154.
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      178. Tanaka N, Fukuyama S, Fukuiwa T, Kawabata M, Sagara Y, Ito HO, Miwa Y, Nagatake T, Kiyono H, Kurono Y. Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine. 2007 Mar 30; 25(14):2680-7. PMID: 17270319.
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      179. Maddaloni M, Staats HF, Mierzejewska D, Hoyt T, Robinson A, Callis G, Kozaki S, Kiyono H, McGhee JR, Fujihashi K, Pascual DW. Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. J Immunol. 2006 Oct 15; 177(8):5524-32. PMID: 17015739.
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      180. Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H. Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J Immunol. 2006 Oct 1; 177(7):4276-80. PMID: 16982861.
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      181. Hagiwara Y, Kawamura YI, Kataoka K, Rahima B, Jackson RJ, Komase K, Dohi T, Boyaka PN, Takeda Y, Kiyono H, McGhee JR, Fujihashi K. A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking. J Immunol. 2006 Sep 1; 177(5):3045-54. PMID: 16920941; NIHMSID: NIHMS73474.
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      182. Duverger A, Jackson RJ, van Ginkel FW, Fischer R, Tafaro A, Leppla SH, Fujihashi K, Kiyono H, McGhee JR, Boyaka PN. Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J Immunol. 2006 Feb 1; 176(3):1776-83. PMID: 16424208.
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      183. Jang MH, Sougawa N, Tanaka T, Hirata T, Hiroi T, Tohya K, Guo Z, Umemoto E, Ebisuno Y, Yang BG, Seoh JY, Lipp M, Kiyono H, Miyasaka M. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol. 2006 Jan 15; 176(2):803-10. PMID: 16393963.
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      184. Nochi T, Kiyono H. Innate immunity in the mucosal immune system. Curr Pharm Des. 2006; 12(32):4203-13. PMID: 17100623.
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      185. Yuki Y, Hara-Yakoyama C, Guadiz AA, Udaka S, Kiyono H, Chatterjee S. Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes. Biotechnol Bioeng. 2005 Dec 30; 92(7):803-9. PMID: 16142801.
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      186. Takagi H, Hiroi T, Yang L, Tada Y, Yuki Y, Takamura K, Ishimitsu R, Kawauchi H, Kiyono H, Takaiwa F. A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17525-30. PMID: 16278301; PMCID: PMC1297655.
      187. Kunisawa J, Fukuyama S, Kiyono H. Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Curr Mol Med. 2005 Sep; 5(6):557-72. PMID: 16178767.
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      188. Ohmura M, Yamamoto M, Tomiyama-Miyaji C, Yuki Y, Takeda Y, Kiyono H. Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation. Infect Immun. 2005 Jul; 73(7):4088-97. PMID: 15972497; PMCID: PMC1168555.
      189. Kunisawa J, Kiyono H. A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. Cell Mol Life Sci. 2005 Jun; 62(12):1308-21. PMID: 15971106.
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      190. Hino A, Fukuyama S, Kataoka K, Kweon MN, Fujihashi K, Kiyono H. Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea. J Immunol. 2005 Jun 1; 174(11):7423-32. PMID: 15905591.
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      191. Ueta M, Hamuro J, Kiyono H, Kinoshita S. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005 May 27; 331(1):285-94. PMID: 15845391.
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      192. Nochi T, Kiyono H. [Mucosal immunology]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:14-9. PMID: 15861629.
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      193. Yamamoto M, Kiyono H. [Host defence mechanisms offered by the mucosal immune system]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:447-53. PMID: 15861694.
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      194. Kai Y, Takahashi I, Ishikawa H, Hiroi T, Mizushima T, Matsuda C, Kishi D, Hamada H, Tamagawa H, Ito T, Yoshizaki K, Kishimoto T, Matsuda H, Kiyono H. Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells. Gastroenterology. 2005 Apr; 128(4):922-34. PMID: 15825075.
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      195. Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, Kiyono H. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J Immunol. 2005 Apr 1; 174(7):4365-72. PMID: 15778401.
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      196. Nonaka S, Naito T, Chen H, Yamamoto M, Moro K, Kiyono H, Hamada H, Ishikawa H. Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J Immunol. 2005 Feb 15; 174(4):1906-12. PMID: 15699117.
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      197. Kobayashi R, Kohda T, Kataoka K, Ihara H, Kozaki S, Pascual DW, Staats HF, Kiyono H, McGhee JR, Fujihashi K. A novel neurotoxoid vaccine prevents mucosal botulism. J Immunol. 2005 Feb 15; 174(4):2190-5. PMID: 15699151.
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      198. Yoshino N, Lü FX, Fujihashi K, Hagiwara Y, Kataoka K, Lu D, Hirst L, Honda M, van Ginkel FW, Takeda Y, Miller CJ, Kiyono H, McGhee JR. A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. J Immunol. 2004 Dec 1; 173(11):6850-7. PMID: 15557179.
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      199. Nochi T, Yuki Y, Terahara K, Hino A, Kunisawa J, Kweon MN, Yamaguchi T, Kiyono H. Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium. Clin Immunol. 2004 Dec; 113(3):326-39. PMID: 15507398.
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      200. Ohmura-Hoshino M, Yamamoto M, Yuki Y, Takeda Y, Kiyono H. Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity. Vaccine. 2004 Sep 9; 22(27-28):3751-61. PMID: 15315856.
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      201. Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol. 2004 Sep 1; 173(5):3337-47. PMID: 15322197.
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      202. Kiyono H, Fukuyama S. NALT- versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol. 2004 Sep; 4(9):699-710. PMID: 15343369.
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      203. Yamamoto M, Kweon MN, Rennert PD, Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity. J Immunol. 2004 Jul 15; 173(2):762-9. PMID: 15240662.
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      204. Shikina T, Hiroi T, Iwatani K, Jang MH, Fukuyama S, Tamura M, Kubo T, Ishikawa H, Kiyono H. IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J Immunol. 2004 May 15; 172(10):6259-64. PMID: 15128814.
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      205. Mizushima T, Ito T, Kishi D, Kai Y, Tamagawa H, Nezu R, Kiyono H, Matsuda H. Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. Inflamm Bowel Dis. 2004 May; 10(3):182-92. PMID: 15290910.
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      206. Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K, Sasakawa C, Suzuki T, Nochi T, Yokota Y, Rennert PD, Hiroi T, Tamagawa H, Iijima H, Kunisawa J, Yuki Y, Kiyono H. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6110-5. PMID: 15071180; PMCID: PMC395931.
      207. Hino A, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea. Am J Pathol. 2004 Apr; 164(4):1327-35. PMID: 15039220; PMCID: PMC1615363.
      208. Kiyono H. [Disease condition and the mechanism of the development of type 2 diabetes mellitus]. Nihon Naika Gakkai Zasshi. 2004 Feb 20; 93 Suppl:48-51. PMID: 15038121.
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      209. Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki J, Kiyono H. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. J Immunol. 2003 Oct 15; 171(8):4131-9. PMID: 14530335.
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      210. Yuki Y, Kiyono H. New generation of mucosal adjuvants for the induction of protective immunity. Rev Med Virol. 2003 Sep-Oct; 13(5):293-310. PMID: 12931340.
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      211. Tamagawa H, Takahashi I, Furuse M, Yoshitake-Kitano Y, Tsukita S, Ito T, Matsuda H, Kiyono H. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab Invest. 2003 Jul; 83(7):1045-53. PMID: 12861044.
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      212. Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K, Akira S. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest. 2003 May; 111(9):1297-308. PMID: 12727921; PMCID: PMC154445.
      213. Jang MH, Kweon MN, Hiroi T, Yamamoto M, Takahashi I, Kiyono H. Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells. Vaccine. 2003 Apr 2; 21(15):1613-9. PMID: 12639482.
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      214. Hagiwara Y, McGhee JR, Fujihashi K, Kobayashi R, Yoshino N, Kataoka K, Etani Y, Kweon MN, Tamura S, Kurata T, Takeda Y, Kiyono H, Fujihashi K. Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. J Immunol. 2003 Feb 15; 170(4):1754-62. PMID: 12574339.
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      215. Boyaka PN, Ohmura M, Fujihashi K, Koga T, Yamamoto M, Kweon MN, Takeda Y, Jackson RJ, Kiyono H, Yuki Y, McGhee JR. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. J Immunol. 2003 Jan 1; 170(1):454-62. PMID: 12496431.
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      216. Sakaue G, Hiroi T, Nakagawa Y, Someya K, Iwatani K, Sawa Y, Takahashi H, Honda M, Kunisawa J, Kiyono H. HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. J Immunol. 2003 Jan 1; 170(1):495-502. PMID: 12496436.
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      217. Okuda Y, Takahashi I, Kim JK, Ohta N, Iwatani K, Iijima H, Kai Y, Tamagawa H, Hiroi T, Kweon MN, Kawano S, Takeda K, Akira S, Sasaki Y, Hori M, Kiyono H. Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells. Am J Pathol. 2003 Jan; 162(1):263-71. PMID: 12507909; PMCID: PMC1851110.
      218. Kweon MN, Kiyono H. Eosinophilic gastroenteritis: a problem of the mucosal immune system? Curr Allergy Asthma Rep. 2003 Jan; 3(1):79-85. PMID: 12542999.
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      219. Kawahara M, Matsuo K, Nakasone T, Hiroi T, Kiyono H, Matsumoto S, Yamada T, Yamamoto N, Honda M. Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen. Vaccine. 2002 Dec 13; 21(3-4):158-66. PMID: 12450689.
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      220. Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, Kiyono H. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. J Immunol. 2002 Dec 1; 169(11):6187-92. PMID: 12444123.
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      221. Yuki Y, Kiyono H. [M cells: development and function]. Tanpakushitsu Kakusan Koso. 2002 Dec; 47(16 Suppl):2325-30. PMID: 12518456.
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      222. Watanabe I, Hagiwara Y, Kadowaki SE, Yoshikawa T, Komase K, Aizawa C, Kiyono H, Takeda Y, McGhee JR, Chiba J, Sata T, Kurata T, Tamura S. Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K). Vaccine. 2002 Oct 4; 20(29-30):3443-55. PMID: 12297389.
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      223. Kweon MN, Yamamoto M, Watanabe F, Tamura S, Van Ginkel FW, Miyauchi A, Takagi H, Takeda Y, Hamabata T, Fujihashi K, McGhee JR, Kiyono H. A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies. J Infect Dis. 2002 Nov 1; 186(9):1261-9. PMID: 12402195.
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      224. Yanagita M, Shimabukuro Y, Nozaki T, Yoshimura N, Watanabe J, Koide H, Terakura M, Saho T, Takedachi M, Jang MH, Kiyono H, Murakami S. IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):329-34. PMID: 12237122.
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      225. Ueta M, Kweon MN, Sano Y, Sotozono C, Yamada J, Koizumi N, Kiyono H, Kinoshita S. Immunosuppressive properties of human amniotic membrane for mixed lymphocyte reaction. Clin Exp Immunol. 2002 Sep; 129(3):464-70. PMID: 12197887; PMCID: PMC1906465.
      226. Kunisawa J, Takahashi I, Okudaira A, Hiroi T, Katayama K, Ariyama T, Tsutsumi Y, Nakagawa S, Kiyono H, Mayumi T. Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur J Immunol. 2002 Aug; 32(8):2347-55. PMID: 12209648.
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      227. Suenobu N, Kweon MN, Kiyono H. Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis. Vaccine. 2002 Jul 26; 20(23-24):2972-80. PMID: 12126910.
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      228. Enose Y, Ui M, Miyake A, Suzuki H, Uesaka H, Kuwata T, Kunisawa J, Kiyono H, Takahashi H, Miura T, Hayami M. Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV. Virology. 2002 Jul 5; 298(2):306-16. PMID: 12127792.
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      229. Fukuyama S, Hiroi T, Yokota Y, Rennert PD, Yanagita M, Kinoshita N, Terawaki S, Shikina T, Yamamoto M, Kurono Y, Kiyono H. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity. 2002 Jul; 17(1):31-40. PMID: 12150889.
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      230. Ohta N, Hiroi T, Kweon MN, Kinoshita N, Jang MH, Mashimo T, Miyazaki J, Kiyono H. IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation. J Immunol. 2002 Jul 1; 169(1):460-8. PMID: 12077277.
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      231. Takahashi I, Matsuda J, Gapin L, DeWinter H, Kai Y, Tamagawa H, Kronenberg M, Kiyono H. Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice. Clin Immunol. 2002 Mar; 102(3):237-48. PMID: 11890710.
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      232. Kweon MN, Takahashi I, Yamamoto M, Jang MH, Suenobu N, Kiyono H. Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4(+) CD45RB(+) T cells. Gut. 2002 Mar; 50(3):299-306. PMID: 11839705; PMCID: PMC1773154.
      233. Hamada H, Hiroi T, Nishiyama Y, Takahashi H, Masunaga Y, Hachimura S, Kaminogawa S, Takahashi-Iwanaga H, Iwanaga T, Kiyono H, Yamamoto H, Ishikawa H. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol. 2002 Jan 1; 168(1):57-64. PMID: 11751946.
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      234. Kweon MN, Kiyono H. CD40L in autoimmunity and mucosally induced tolerance. J Clin Invest. 2002 Jan; 109(2):171-3. PMID: 11805128; PMCID: PMC150848.
      235. Ohmura M, Yamamoto M, Kiyono H, Fujihashi K, Takeda Y, McGhee JR. Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin. Vaccine. 2001 Dec 12; 20(5-6):756-62. PMID: 11738739.
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      236. Hiroi T, Goto H, Someya K, Yanagita M, Honda M, Yamanaka N, Kiyono H. HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions. J Immunol. 2001 Nov 15; 167(10):5862-7. PMID: 11698461.
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      237. Jones HP, Hodge LM, Fujihashi K, Kiyono H, McGhee JR, Simecka JW. The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J Immunol. 2001 Oct 15; 167(8):4518-26. PMID: 11591779.
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      238. Yura M, Takahashi I, Terawaki S, Hiroi T, Kweon MN, Yuki Y, Kiyono H. Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE). Vaccine. 2001 Oct 12; 20(1-2):134-9. PMID: 11567757.
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      239. Kim JK, Takahashi I, Kai Y, Kiyono H. Influence of enterotoxin on mucosal intranet: selective inhibition of extrathymic T cell development in intestinal intraepithelial lymphocytes by oral exposure to heat-labile toxin. Eur J Immunol. 2001 Oct; 31(10):2960-9. PMID: 11592072.
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      240. Fujihashi K, Kato H, van Ginkel FW, Koga T, Boyaka PN, Jackson RJ, Kato R, Hagiwara Y, Etani Y, Goma I, Fujihashi K, Kiyono H, McGhee JR. A revisit of mucosal IgA immunity and oral tolerance. Acta Odontol Scand. 2001 Oct; 59(5):301-8. PMID: 11680650.
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      241. Schenck K, Kiyono H, Helgeland K, Steinsvoll S, Taylor B. Immunologic tolerance: the good, the bad, and the ugly. Acta Odontol Scand. 2001 Oct; 59(5):297-300. PMID: 11762300.
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      242. Dohi T, Rennert PD, Fujihashi K, Kiyono H, Shirai Y, Kawamura YI, Browning JL, McGhee JR. Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis. J Immunol. 2001 Sep 1; 167(5):2781-90. PMID: 11509623.
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      243. Kunisawa J, Nakanishi T, Takahashi I, Okudaira A, Tsutsumi Y, Katayama K, Nakagawa S, Kiyono H, Mayumi T. Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system. J Immunol. 2001 Aug 1; 167(3):1406-12. PMID: 11466359.
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      244. Schenck K, Helgeland K, Kiyono H. New Frontiers in Oral Immunological Diseases. Proceedings of a Conference. Lillehammer, Norway, 23-27 February 2001. Part 2. Acta Odontol Scand. 2001 Aug; 59(4):209-11. PMID: 11699491.
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      245. Yura M, Takahashi I, Serada M, Koshio T, Nakagami K, Yuki Y, Kiyono H. Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). J Autoimmun. 2001 Aug; 17(1):17-25. PMID: 11488634.
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      246. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T. NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport. 2001 Jul 20; 12(10):2079-84. PMID: 11447311.
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      247. Yuki Y, Byun Y, Fujita M, Izutani W, Suzuki T, Udaka S, Fujihashi K, McGhee JR, Kiyono H. Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis. Biotechnol Bioeng. 2001 Jul 5; 74(1):62-9. PMID: 11353411.
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      248. Shimizu M, Minakuchi K, Tsuda A, Hiroi T, Tanaka N, Koga J, Kiyono H. Role of stem cell factor and c-kit signaling in regulation of fetal intestinal epithelial cell adhesion to fibronectin. Exp Cell Res. 2001 Jun 10; 266(2):311-22. PMID: 11399059.
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      249. Kim JK, Takahashi I, Okuda Y, Itakura M, McGhee JR, Kiyono H. T cell receptor dynamism of mucosal and systemic CD4+ T cells in the course of an immune response to Escherichia coli heat-labile enterotoxin. J Infect Dis. 2001 Jul 1; 184(1):43-51. PMID: 11398108.
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      250. Schenck K, Kiyono H. Innate and acquired immunity, cytokines, and genetic factors in relation to the mucosal immune system. Acta Odontol Scand. 2001 Jun; 59(3):121-3. PMID: 11501879.
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      251. Kiyono H, Kweon MN, Hiroi T, Takahashi I. The mucosal immune system: from specialized immune defense to inflammation and allergy. Acta Odontol Scand. 2001 Jun; 59(3):145-53. PMID: 11501883.
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      252. Ohta N, Shimaoka M, Imanaka H, Nishimura M, Taenaka N, Kiyono H, Yoshiya I. Glucocorticoid suppresses neutrophil activation in ventilator-induced lung injury. Crit Care Med. 2001 May; 29(5):1012-6. PMID: 11378614.
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      253. Hodge LM, Marinaro M, Jones HP, McGhee JR, Kiyono H, Simecka JW. Immunoglobulin A (IgA) responses and IgE-associated inflammation along the respiratory tract after mucosal but not systemic immunization. Infect Immun. 2001 Apr; 69(4):2328-38. PMID: 11254590; PMCID: PMC98162.
      254. Fujihashi K, Dohi T, Rennert PD, Yamamoto M, Koga T, Kiyono H, McGhee JR. Peyer's patches are required for oral tolerance to proteins. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3310-5. PMID: 11248075; PMCID: PMC30650.
      255. Yamamoto M, McGhee JR, Hagiwara Y, Otake S, Kiyono H. Genetically manipulated bacterial toxin as a new generation mucosal adjuvant. Scand J Immunol. 2001 Mar; 53(3):211-7. PMID: 11251876.
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      256. Kim J, Kiyono H. [The gastrointestinal immune system: cholera toxin and E. coli heat-labile enterotoxin as immunomodulators]. Tanpakushitsu Kakusan Koso. 2001 Mar; 46(4 Suppl):547-55. PMID: 11268659.
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      257. Iijima H, Takahashi I, Kiyono H. Mucosal immune network in the gut for the control of infectious diseases. Rev Med Virol. 2001 Mar-Apr; 11(2):117-33. PMID: 11262530.
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      258. Byun Y, Ohmura M, Fujihashi K, Yamamoto S, McGhee JR, Udaka S, Kiyono H, Takeda Y, Kohsaka T, Yuki Y. Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies. Vaccine. 2001 Feb 28; 19(15-16):2061-70. PMID: 11228378.
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      259. Imanaka H, Shimaoka M, Matsuura N, Nishimura M, Ohta N, Kiyono H. Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta 1 mRNA upregulation in rat lungs. Anesth Analg. 2001 Feb; 92(2):428-36. PMID: 11159246.
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      260. Saito M, Otake S, Ohmura M, Hirasawa M, Takada K, Mega J, Takahashi I, Kiyono H, McGhee JR, Takeda Y, Yamamoto M. Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant. J Infect Dis. 2001 Mar 1; 183(5):823-6. PMID: 11181162.
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      261. Kweon M, Takahashi I, Kiyono H. New insights into mechanism of inflammatory and allergic diseases in mucosal tissues. Digestion. 2001; 63 Suppl 1:1-11. PMID: 11173903.
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      262. Kiyono H. Mucosal immune system: close encounter in the uncharted world of immunology. Ophthalmologica. 2001; 215 Suppl 1:22-32. PMID: 11276896.
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      263. Kunisawa J, Sakaue G, Kiyono H. [NALT immune system for the development of AIDS mucosal vaccine]. Nihon Rinsho Meneki Gakkai Kaishi. 2000 Dec; 23(6):579-81. PMID: 11210747.
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      264. Boyaka PN, Wright PF, Marinaro M, Kiyono H, Johnson JE, Gonzales RA, Ikizler MR, Werkhaven JA, Jackson RJ, Fujihashi K, Di Fabio S, Staats HF, McGhee JR. Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. Am J Pathol. 2000 Dec; 157(6):2023-35. PMID: 11106575; PMCID: PMC1885777.
      265. Kishi D, Takahashi I, Kai Y, Tamagawa H, Iijima H, Obunai S, Nezu R, Ito T, Matsuda H, Kiyono H. Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice. J Immunol. 2000 Nov 15; 165(10):5891-9. PMID: 11067950.
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      266. Koga T, McGhee JR, Kato H, Kato R, Kiyono H, Fujihashi K. Evidence for early aging in the mucosal immune system. J Immunol. 2000 Nov 1; 165(9):5352-9. PMID: 11046071.
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      267. Hiroi T, Yanagita M, Ohta N, Sakaue G, Kiyono H. IL-15 and IL-15 receptor selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses. J Immunol. 2000 Oct 15; 165(8):4329-37. PMID: 11035068.
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      268. Kunisawa J, Okudaira A, Tsutusmi Y, Takahashi I, Nakanishi T, Kiyono H, Mayumi T. Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses. Vaccine. 2000 Oct 15; 19(4-5):589-94. PMID: 11027825.
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      269. Dohi T, Fujihashi K, Kiyono H, Elson CO, McGhee JR. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology. 2000 Sep; 119(3):724-33. PMID: 10982767.
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      270. Kweon MN, Yamamoto M, Kajiki M, Takahashi I, Kiyono H. Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea. J Clin Invest. 2000 Jul; 106(2):199-206. PMID: 10903335; PMCID: PMC314304.
      271. Yamamoto M, Kiyono H, Kweon MN, Yamamoto S, Fujihashi K, Kurazono H, Imaoka K, Bluethmann H, Takahashi I, Takeda Y, Azuma M, McGhee JR. Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses. J Infect Dis. 2000 Jul; 182(1):180-90. PMID: 10882596.
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      272. Yamamoto M, Rennert P, McGhee JR, Kweon MN, Yamamoto S, Dohi T, Otake S, Bluethmann H, Fujihashi K, Kiyono H. Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J Immunol. 2000 May 15; 164(10):5184-91. PMID: 10799877.
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      273. Higuchi K, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. Comparison of nasal and oral tolerance for the prevention of collagen induced murine arthritis. J Rheumatol. 2000 Apr; 27(4):1038-44. PMID: 10782834.
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      274. Simecka JW, Jackson RJ, Kiyono H, McGhee JR. Mucosally induced immunoglobulin E-associated inflammation in the respiratory tract. Infect Immun. 2000 Feb; 68(2):672-9. PMID: 10639432; PMCID: PMC97191.
      275. Saitoh-Inagawa W, Hiroi T, Yanagita M, Iijima H, Uchio E, Ohno S, Aoki K, Kiyono H. Unique characteristics of lacrimal glands as a part of mucosal immune network: high frequency of IgA-committed B-1 cells and NK1.1+ alphabeta T cells. Invest Ophthalmol Vis Sci. 2000 Jan; 41(1):138-44. PMID: 10634613.
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      276. Pascual DW, Hone DM, Hall S, van Ginkel FW, Yamamoto M, Walters N, Fujihashi K, Powell RJ, Wu S, Vancott JL, Kiyono H, McGhee JR. Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infect Immun. 1999 Dec; 67(12):6249-56. PMID: 10569734; PMCID: PMC97026.
      277. Fujihashi K, Dohi T, Kweon MN, McGhee JR, Koga T, Cooper MD, Tonegawa S, Kiyono H. gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion. Int Immunol. 1999 Dec; 11(12):1907-16. PMID: 10590256.
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      278. Tori M, Ito T, Yumiba T, Okawa A, Maeda A, Sawai T, Kiyomoto T, Akamaru Y, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. Proliferation of donor-derived NKR-P1+TCR alpha beta + (NKT) cells in the nonrecurrent spontaneous diabetic BB rats transplanted with pancreaticoduodenal grafts of Wistar-Furth donors. Transplant Proc. 1999 Nov; 31(7):2741-2. PMID: 10578272.
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      279. Mbawuike IN, Fujihashi K, DiFabio S, Kawabata S, McGhee JR, Couch RB, Kiyono H. Human interleukin-12 enhances interferon-gamma-producing influenza-specific memory CD8+ cytotoxic T lymphocytes. J Infect Dis. 1999 Nov; 180(5):1477-86. PMID: 10515806.
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      280. Kurono Y, Suzuki M, Mogi G, Yamamoto M, Fujihashi K, McGhee JR, Kiyono H. Effects of intranasal immunization on protective immunity against otitis media. Int J Pediatr Otorhinolaryngol. 1999 Oct 5; 49 Suppl 1:S227-9. PMID: 10577810.
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      281. Iijima H, Takahashi I, Kishi D, Kim JK, Kawano S, Hori M, Kiyono H. Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice. J Exp Med. 1999 Sep 6; 190(5):607-15. PMID: 10477546; PMCID: PMC2195615.
      282. Hoft DF, Kemp EB, Marinaro M, Cruz O, Kiyono H, McGhee JR, Belisle JT, Milligan TW, Miller JP, Belshe RB. A double-blind, placebo-controlled study of Mycobacterium-specific human immune responses induced by intradermal bacille Calmette-Guérin vaccination. J Lab Clin Med. 1999 Sep; 134(3):244-52. PMID: 10482309.
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      283. Takahashi I, Kiyono H. Gut as the largest immunologic tissue. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct; 23(5 Suppl):S7-12. PMID: 10483885.
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      284. van Ginkel FW, Wahl SM, Kearney JF, Kweon MN, Fujihashi K, Burrows PD, Kiyono H, McGhee JR. Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice. J Immunol. 1999 Aug 15; 163(4):1951-7. PMID: 10438931.
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      285. Tori M, Ito T, Yumiba T, Ohkawa A, Maeda A, Sawai T, Kiyomoto T, Akamaru Y, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. IL-4 production in IDDM-nonrecurrent pancreas-transplanted BB rats with donor-derived NKR-P1+TCR alpha beta + (NKT) cells, but not in IDDM-recurrent BB rats. Transplant Proc. 1999 Aug; 31(5):1940-1. PMID: 10455925.
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      286. Kurono Y, Yamamoto M, Fujihashi K, Kodama S, Suzuki M, Mogi G, McGhee JR, Kiyono H. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. J Infect Dis. 1999 Jul; 180(1):122-32. PMID: 10353870.
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      287. Yamamoto M, Kiyono H, Yamamoto S, Batanero E, Kweon MN, Otake S, Azuma M, Takeda Y, McGhee JR. Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant. J Immunol. 1999 Jun 15; 162(12):7015-21. PMID: 10358143.
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      288. McGhee JR, Kiyono H, Kubota M, Kawabata S, Miller CJ, Lehner T, Imaoka K, Fujihashi K. Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques. J Infect Dis. 1999 May; 179 Suppl 3:S480-4. PMID: 10099124.
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      289. Dohi T, Fujihashi K, Rennert PD, Iwatani K, Kiyono H, McGhee JR. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med. 1999 Apr 19; 189(8):1169-80. PMID: 10209035; PMCID: PMC2193023.
      290. Boyaka PN, Marinaro M, Vancott JL, Takahashi I, Fujihashi K, Yamamoto M, van Ginkel FW, Jackson RJ, Kiyono H, McGhee JR. Strategies for mucosal vaccine development. Am J Trop Med Hyg. 1999 Apr; 60(4 Suppl):35-45. PMID: 10344675.
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      291. Yanagita M, Hiroi T, Kitagaki N, Hamada S, Ito HO, Shimauchi H, Murakami S, Okada H, Kiyono H. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. J Immunol. 1999 Mar 15; 162(6):3559-65. PMID: 10092814.
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      292. Yamamoto M, Kiyono H. Immunoregulatory functions of mucosal gammadelta T cells. Microbes Infect. 1999 Mar; 1(3):241-6. PMID: 10801236.
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      293. Kweon MN, Fujihashi K, Wakatsuki Y, Koga T, Yamamoto M, McGhee JR, Kiyono H. Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions. J Immunol. 1999 Feb 15; 162(4):1904-9. PMID: 9973457.
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      294. Takahashi I, Iijima H, Katashima R, Itakura M, Kiyono H. Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain- deficient mice by gut-derived antigens. J Immunol. 1999 Feb 1; 162(3):1843-50. PMID: 9973450.
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      295. Nguyen HH, Moldoveanu Z, Novak MJ, van Ginkel FW, Ban E, Kiyono H, McGhee JR, Mestecky J. Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues. Virology. 1999 Feb 1; 254(1):50-60. PMID: 9927573.
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      296. Hiroi T, Yanagita M, Iijima H, Iwatani K, Yoshida T, Takatsu K, Kiyono H. Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues. J Immunol. 1999 Jan 15; 162(2):821-8. PMID: 9916704.
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      297. Sugimoto M, Shimaoka M, Taenaka N, Kiyono H, Yoshiya I. Lymphocyte activation is attenuated by stellate ganglion block. Reg Anesth Pain Med. 1999 Jan-Feb; 24(1):30-5. PMID: 9952092.
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      298. Marinaro M, Boyaka PN, Jackson RJ, Finkelman FD, Kiyono H, Jirillo E, McGhee JR. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin. J Immunol. 1999 Jan 1; 162(1):114-21. PMID: 9886376.
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      299. Boyaka PN, Marinaro M, Jackson RJ, Menon S, Kiyono H, Jirillo E, McGhee JR. IL-12 is an effective adjuvant for induction of mucosal immunity. J Immunol. 1999 Jan 1; 162(1):122-8. PMID: 9886377.
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      300. Takahashi I, Lijima H, Kishi D, Kiyono H. Oligoclonal Th2-biased betabeta T cells induce murine inflammatory bowel disease. Immunol Res. 1999; 20(3):237-42. PMID: 10741863.
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      301. Tori M, Ito T, Yumiba T, Maeda A, Sawai T, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. Significant role of intragraft lymphoid tissues in preventing insulin-dependent diabetes mellitus recurrence in whole pancreaticoduodenal transplantation. Microsurgery. 1999; 19(7):338-43. PMID: 10586200.
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      302. Kobayashi T, Yamamoto M, Hiroi T, McGhee J, Takeshita Y, Kiyono H. Arginine enhances induction of T helper 1 and T helper 2 cytokine synthesis by Peyer's patch alpha beta T cells and antigen-specific mucosal immune response. Biosci Biotechnol Biochem. 1998 Dec; 62(12):2334-40. PMID: 9972259.
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      303. Imaoka K, Miller CJ, Kubota M, McChesney MB, Lohman B, Yamamoto M, Fujihashi K, Someya K, Honda M, McGhee JR, Kiyono H. Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues. J Immunol. 1998 Dec 1; 161(11):5952-8. PMID: 9834076.
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      304. Shimaoka M, Hosotsubo K, Sugimoto M, Sakaue G, Taenaka N, Yoshiya I, Kiyono H. The influence of surgical stress on T cells: enhancement of early phase lymphocyte activation. Anesth Analg. 1998 Dec; 87(6):1431-5. PMID: 9842843.
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      305. VanCott JL, Chatfield SN, Roberts M, Hone DM, Hohmann EL, Pascual DW, Yamamoto M, Kiyono H, McGhee JR. Regulation of host immune responses by modification of Salmonella virulence genes. Nat Med. 1998 Nov; 4(11):1247-52. PMID: 9809547.
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      306. Harris PR, Ernst PB, Kawabata S, Kiyono H, Graham MF, Smith PD. Recombinant Helicobacter pylori urease activates primary mucosal macrophages. J Infect Dis. 1998 Nov; 178(5):1516-20. PMID: 9780278.
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      307. Iijima H, Takahashi I, Hiroi T, Shimaoka M, Kawano S, Nagano K, Hori M, Kiyono H. Orally administered cholera toxin prevents murine intestinal T cells from staphylococcal enterotoxin B-induced anergy. Gastroenterology. 1998 Nov; 115(5):1197-204. PMID: 9797375.
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      308. Itoh M, Ishihara K, Hiroi T, Lee BO, Maeda H, Iijima H, Yanagita M, Kiyono H, Hirano T. Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J Immunol. 1998 Oct 15; 161(8):3974-83. PMID: 9780166.
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      309. Yamamoto M, Briles DE, Yamamoto S, Ohmura M, Kiyono H, McGhee JR. A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A. J Immunol. 1998 Oct 15; 161(8):4115-21. PMID: 9780183.
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      310. Kawabata S, Boyaka PN, Coste M, Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics. Gastroenterology. 1998 Oct; 115(4):866-73. PMID: 9753489.
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      311. Hiroi T, Iwatani K, Iijima H, Kodama S, Yanagita M, Kiyono H. Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively. Eur J Immunol. 1998 Oct; 28(10):3346-53. PMID: 9808204.
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      312. Marinaro M, Boyaka PN, Kiyono H, McGhee JR. Novel approaches for the induction of T helper 1 (Th1)- or Th2-type mucosal and parenteral immune responses. Expert Opin Investig Drugs. 1998 Oct; 7(10):1657-66. PMID: 15991907.
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      313. Dohi T, Kiyono H. [Dysregulation of mucosal immunity and inflammatory bowel diseases]. Nihon Rinsho. 1998 Jun; 56(6):1619-26. PMID: 9648492.
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      314. Nguyen HH, Boyaka PN, Moldoveanu Z, Novak MJ, Kiyono H, McGhee JR, Mestecky J. Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes. J Virol. 1998 May; 72(5):4534-6. PMID: 9557755; PMCID: PMC109702.
      315. Salvi GE, Brown CE, Fujihashi K, Kiyono H, Smith FW, Beck JD, Offenbacher S. Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. J Periodontal Res. 1998 May; 33(4):212-25. PMID: 9689617.
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      316. Sugimoto M, Shimaoka M, Hosotsubo K, Tanigami H, Taenaka N, Kiyono H, Yoshiya I. Up-regulation of Fas ligand (FasL) mRNA expression in peripheral blood mononuclear cells (PBMC) after major surgery. Clin Exp Immunol. 1998 Apr; 112(1):120-5. PMID: 9566799; PMCID: PMC1904941.
      317. Yuki Y, Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Human milk proteins including secretory IgA fail to elicit tolerance after feeding. Int Immunol. 1998 Apr; 10(4):537-45. PMID: 9620610.
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      318. Yamamoto M, Fujihashi K, Kawabata K, McGhee JR, Kiyono H. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J Immunol. 1998 Mar 1; 160(5):2188-96. PMID: 9498757.
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      319. Kweon MN, Fujihashi K, VanCott JL, Higuchi K, Yamamoto M, McGhee JR, Kiyono H. Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice. J Immunol. 1998 Feb 15; 160(4):1687-93. PMID: 9469425.
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      320. Kawabata S, Miller CJ, Lehner T, Fujihashi K, Kubota M, McGhee JR, Imaoka K, Hiroi T, Kiyono H. Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques. J Infect Dis. 1998 Jan; 177(1):26-33. PMID: 9419166.
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      321. Wilcox CM, Harris PR, Redman TK, Kawabata S, Hiroi T, Kiyono H, Smith PD. High mucosal levels of tumor necrosis factor alpha messenger RNA in AIDS-associated cytomegalovirus-induced esophagitis. Gastroenterology. 1998 Jan; 114(1):77-82. PMID: 9428221.
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      322. Lü X, Kiyono H, Lu D, Kawabata S, Torten J, Srinivasan S, Dailey PJ, McGhee JR, Lehner T, Miller CJ. Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251. AIDS. 1998 Jan 1; 12(1):1-10. PMID: 9456249; NIHMSID: NIHMS157301.
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      323. Takahashi I, Kiyono H. Gamma delta T cells: bodyguards and/or sleepers in the gut. Chem Immunol. 1998; 71:77-87. PMID: 9761948.
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      324. Kawabata S, Boyaka PN, Coste M, Fujihashi K, Hamada S, McGhee JR, Kiyono H. A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine. Biochem Biophys Res Commun. 1997 Dec 29; 241(3):797-802. PMID: 9434789.
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      325. Yamada K, Shimaoka M, Nagayama K, Hiroi T, Kiyono H, Honda T. Bacterial invasion induces interleukin-7 receptor expression in colonic epithelial cell line, T84. Eur J Immunol. 1997 Dec; 27(12):3456-60. PMID: 9464835.
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      326. Pascual DW, Coste M, Boyaka PN, Kiyono H, McGhee JR. Spontaneously hypertensive rat: cholera toxin converts suppression to immunity through a Th2 cell-IL-4 pathway. Am J Physiol. 1997 Oct; 273(4 Pt 2):R1509-18. PMID: 9362318.
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      327. Fujihashi K, McGhee JR, Yamamoto M, Peschon JJ, Kiyono H. An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state. Eur J Immunol. 1997 Sep; 27(9):2133-8. PMID: 9341750.
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      328. van Ginkel FW, McGhee JR, Liu C, Simecka JW, Yamamoto M, Frizzell RA, Sorscher EJ, Kiyono H, Pascual DW. Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene. J Immunol. 1997 Jul 15; 159(2):685-93. PMID: 9218583.
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      329. Ban EM, van Ginkel FW, Simecka JW, Kiyono H, Robinson HL, McGhee JR. Mucosal immunization with DNA encoding influenza hemagglutinin. Vaccine. 1997 Jun; 15(8):811-3. PMID: 9234521.
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      330. Kubota M, Miller CJ, Imaoka K, Kawabata S, Fujihashi K, McGhee JR, Kiyono H. Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates. J Immunol. 1997 Jun 1; 158(11):5321-9. PMID: 9164952.
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      331. Yamamoto M, Kweon MN, Kiyono H. [The mechanisms of oral tolerance]. Nihon Rinsho. 1997 Jun; 55(6):1444-9. PMID: 9200930.
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      332. Takahashi I, Kiyono H, Hamada S. CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice. Gastroenterology. 1997 Jun; 112(6):1876-86. PMID: 9178680.
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      337. Vancott JL, Kweon M, Fujihashi K, Yamamoto M, Marinaro M, Kiyono H, McGhee JR. Helper T subsets and cytokines for mucosal immunity and tolerance. Behring Inst Mitt. 1997 Feb; (98):44-52. PMID: 9382768.
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      338. Yamamoto M, McDaniel LS, Kawabata K, Briles DE, Jackson RJ, McGhee JR, Kiyono H. Oral immunization with PspA elicits protective humoral immunity against Streptococcus pneumoniae infection. Infect Immun. 1997 Feb; 65(2):640-4. PMID: 9009325; PMCID: PMC176108.
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      340. Wallace M, Scharko AM, Pauza CD, Fisch P, Imaoka K, Kawabata S, Fujihashi K, Kiyono H, Tanaka Y, Bloom BR, Malkovsky M. Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections. Mol Med. 1997 Jan; 3(1):60-71. PMID: 9132281; PMCID: PMC2230098.
      341. Fujihashi K, Kweon MN, Kiyono H, VanCott JL, van Ginkel FW, Yamamoto M, McGhee JR. A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity. Springer Semin Immunopathol. 1997; 18(4):477-94. PMID: 9144866.
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      342. Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodontal Res. 1997 Jan; 32(1 Pt 2):115-9. PMID: 9085220.
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      343. Marinaro M, Boyaka PN, Jackson RJ, Finkelman FD, Kiyono H, McGhee JR. Interleukin-12 alters helper T-cell subsets and antibody profiles induced by the mucosal adjuvant cholera toxin. Ann N Y Acad Sci. 1996 Oct 31; 795:361-5. PMID: 8958955.
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      344. Elson CO, Beagley KW, Sharmanov AT, Fujihashi K, Kiyono H, Tennyson GS, Cong Y, Black CA, Ridwan BW, McGhee JR. Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. J Immunol. 1996 Sep 1; 157(5):2174-85. PMID: 8757344.
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      345. Nakagawa I, Takahashi I, Kiyono H, McGhee JR, Hamada S. Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches. J Infect Dis. 1996 Jun; 173(6):1428-36. PMID: 8648216.
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      346. Okahashi N, Yamamoto M, Vancott JL, Chatfield SN, Roberts M, Bluethmann H, Hiroi T, Kiyono H, McGhee JR. Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect Immun. 1996 May; 64(5):1516-25. PMID: 8613355; PMCID: PMC173956.
      347. Jackson RJ, Fujihashi K, Kiyono H, McGhee JR. Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses. J Immunol Methods. 1996 Apr 19; 190(2):189-97. PMID: 8621954.
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      348. Fujihashi K, Kawabata S, Hiroi T, Yamamoto M, McGhee JR, Nishikawa S, Kiyono H. Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3613-8. PMID: 8622984; PMCID: PMC39659.
      349. Fujihashi K, McGhee JR, Kweon MN, Cooper MD, Tonegawa S, Takahashi I, Hiroi T, Mestecky J, Kiyono H. gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses. J Exp Med. 1996 Apr 1; 183(4):1929-35. PMID: 8666951; PMCID: PMC2192480.
      350. VanCott JL, Kobayashi T, Yamamoto M, Pillai S, McGhee JR, Kiyono H. Induction of pneumococcal polysaccharide-specific mucosal immune responses by oral immunization. Vaccine. 1996 Apr; 14(5):392-8. PMID: 8735550.
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      351. Takahashi I, Kiyono H, Jackson RJ, Fujihashi K, Staats HF, Hamada S, Clements JD, Bost KL, McGhee JR. Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. Infect Immun. 1996 Apr; 64(4):1290-8. PMID: 8606092; PMCID: PMC173917.
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      354. VanCott JL, Staats HF, Pascual DW, Roberts M, Chatfield SN, Yamamoto M, Coste M, Carter PB, Kiyono H, McGhee JR. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J Immunol. 1996 Feb 15; 156(4):1504-14. PMID: 8568254.
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      355. Fujihashi K, McGhee JR, Yamamoto M, Hiroi T, Kiyono H. Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance. Ann N Y Acad Sci. 1996 Feb 13; 778:55-63. PMID: 8611016.
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      356. Yamamoto M, Vancott JL, Okahashi N, Marinaro M, Kiyono H, Fujihashi K, Jackson RJ, Chatfield SN, Bluethmann H, McGhee JR. The role of Th1 and Th2 cells for mucosal IgA responses. Ann N Y Acad Sci. 1996 Feb 13; 778:64-71. PMID: 8611017.
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      357. Shimaoka M, Hiroi T, Kiyono H. [The IgA immune system for mucosal vaccine: role of levels one and two Th2 cytokine producing T cells]. Nihon Rinsho Meneki Gakkai Kaishi. 1996 Feb; 19(1):114-8. PMID: 8681023.
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      358. Jackson RJ, Marinaro M, VanCott JL, Yamamoto M, Okahashi N, Fujihashi K, Kiyono H, Chatfield SN, McGhee JR. Mucosal immunity: regulation by helper T cells and a novel method for detection. J Biotechnol. 1996 Jan 26; 44(1-3):209-16. PMID: 8717406.
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      359. Simpson SD, Snider DP, Zettel LA, Kiyono H, Unkeless JC, Ernst PB. Soluble FcR block suppressor T cell activity at low concentration in vitro allowing isotype-specific antibody production. Cell Immunol. 1996 Jan 10; 167(1):122-8. PMID: 8548835.
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      360. Yamamoto M, Kawabata K, Fujihashi K, McGhee JR, Van Dyke TE, Bamberg TV, Hiroi T, Kiyono H. Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases. Am J Pathol. 1996 Jan; 148(1):331-9. PMID: 8546223; PMCID: PMC1861600.
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      362. Marinaro M, Staats HF, Hiroi T, Jackson RJ, Coste M, Boyaka PN, Okahashi N, Yamamoto M, Kiyono H, Bluethmann H, Fujihashi K, McGhee JR. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol. 1995 Nov 15; 155(10):4621-9. PMID: 7594461.
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      363. Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells. Eur J Immunol. 1995 Oct; 25(10):2743-51. PMID: 7589066.
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      364. Van Ginkel FW, Liu C, Simecka JW, Dong JY, Greenway T, Frizzell RA, Kiyono H, McGhee JR, Pascual DW. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase. Hum Gene Ther. 1995 Jul; 6(7):895-903. PMID: 7578408.
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      365. Bukawa H, Sekigawa K, Hamajima K, Fukushima J, Yamada Y, Kiyono H, Okuda K. Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. Nat Med. 1995 Jul; 1(7):681-5. PMID: 7585151.
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      366. Takahashi I, Nakagawa I, Kiyono H, McGhee JR, Clements JD, Hamada S. Mucosal T cells induce systemic anergy for oral tolerance. Biochem Biophys Res Commun. 1995 Jan 5; 206(1):414-20. PMID: 7818546.
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      367. Mega J, McGhee JR, Kiyono H. Characterization of cytokine producing T cells, TCR expression, and IgA plasma cells in salivary gland-associated tissues. Adv Exp Med Biol. 1995; 371B:1103-8. PMID: 7502762.
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      368. Novak M, Yamamoto M, Fujihashi K, Moldoveanu Z, Kiyono H, McGhee JR, Mestecky J. Ig-secreting and interferon-gamma-producing cells in mice mucosally immunized with influenza virus. Adv Exp Med Biol. 1995; 371B:1587-90. PMID: 7502861.
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      369. Aicher WK, Eibel H, Fujihashi K, Boehm T, Beagley KW, McGhee JR, Kiyono H. Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenes. Adv Exp Med Biol. 1995; 371A:125-8. PMID: 8525887.
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      370. Pascual DW, Beagley KW, Kiyono H, McGhee JR. Substance P promotes Peyer's patch and splenic B cell differentiation. Adv Exp Med Biol. 1995; 371A:55-9. PMID: 8525987.
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      371. Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues. Eur J Immunol. 1994 Nov; 24(11):2653-8. PMID: 7957557.
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      372. Jackson RJ, Staats HF, Xu-Amano J, Takahashi I, Kiyono H, Hudson ME, Gilley RM, Chatfield SN, McGhee JR. Oral vaccine models: multiple delivery systems employing tetanus toxoid. Ann N Y Acad Sci. 1994 Aug 15; 730:217-34. PMID: 8080173.
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      373. Xu-Amano J, Jackson RJ, Fujihashi K, Kiyono H, Staats HF, McGhee JR. Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. Vaccine. 1994 Aug; 12(10):903-11. PMID: 7975832.
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      374. Staats HF, Jackson RJ, Marinaro M, Takahashi I, Kiyono H, McGhee JR. Mucosal immunity to infection with implications for vaccine development. Curr Opin Immunol. 1994 Aug; 6(4):572-83. PMID: 7946045.
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      375. Pascual DW, Kiyono H, McGhee JR. The enteric nervous and immune systems: interactions for mucosal immunity and inflammation. Immunomethods. 1994 Aug; 5(1):56-72. PMID: 7531102.
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      376. Yamamoto M, Fujihashi K, Amano M, McGhee JR, Beagley KW, Kiyono H. Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 production, while low density T cells undergo DNA fragmentation. Eur J Immunol. 1994 Jun; 24(6):1301-6. PMID: 8206090.
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      377. McGhee JR, Xu-Amano J, Miller CJ, Jackson RJ, Fujihashi K, Staats HF, Kiyono H. The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reprod Fertil Dev. 1994; 6(3):369-79. PMID: 7831485.
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      378. Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Function of alpha beta TCR+ and gamma delta TCR+ IELs for the gastrointestinal immune response. Int Rev Immunol. 1994; 11(1):1-14. PMID: 8057042.
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      379. Di Fabio S, Mbawuike IN, Kiyono H, Fujihashi K, Couch RB, McGhee JR. Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells. Int Immunol. 1994 Jan; 6(1):11-9. PMID: 8148319.
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      380. McGhee JR, Kiyono H. Effective mucosal immunity. Current concepts for vaccine delivery and immune response analysis. Int J Technol Assess Health Care. 1994; 10(1):93-106. PMID: 8157466.
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      381. Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses. J Immunol. 1993 Dec 15; 151(12):6681-91. PMID: 7903096.
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      382. Fujihashi K, Yamamoto M, McGhee JR, Beagley KW, Kiyono H. Function of alpha beta TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8- and CD4+CD8+ T cells for helper activity. Int Immunol. 1993 Nov; 5(11):1473-81. PMID: 8260458.
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      383. McGhee JR, Fujihashi K, Xu-Amano J, Jackson RJ, Elson CO, Beagley KW, Kiyono H. New perspectives in mucosal immunity with emphasis on vaccine development. Semin Hematol. 1993 Oct; 30(4 Suppl 4):3-12; discussion 13-5. PMID: 8303308.
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      384. Xu-Amano J, Kiyono H, Jackson RJ, Staats HF, Fujihashi K, Burrows PD, Elson CO, Pillai S, McGhee JR. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med. 1993 Oct 1; 178(4):1309-20. PMID: 8376936; PMCID: PMC2191217.
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      386. Amano M, McGhee JR, McCutcheon MJ, Fujii K, Kiyono H. Application of the ILISPOT-IDIP system for the enumeration of different sizes of IgA spot forming cells in the murine small and large intestine. J Immunol Methods. 1993 Aug 26; 164(1):79-90. PMID: 8360511.
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      387. Beagley KW, Fujihashi K, Black CA, Lagoo AS, Yamamoto M, McGhee JR, Kiyono H. The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. Eur J Immunol. 1993 Aug; 23(8):2049-52. PMID: 8344373.
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      388. Fujihashi K, Kono Y, Beagley KW, Yamamoto M, McGhee JR, Mestecky J, Kiyono H. Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues. J Periodontol. 1993 May; 64(5 Suppl):400-6. PMID: 8315562.
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      389. Sarawar SR, Carding SR, Allan W, McMickle A, Fujihashi K, Kiyono H, McGhee JR, Doherty PC. Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: consequences of CD4+ and CD8+ T cell depletion. Reg Immunol. 1993 May-Aug; 5(3-4):142-50. PMID: 7902123.
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      390. Fujihashi K, McGhee JR, Beagley KW, McPherson DT, McPherson SA, Huang CM, Kiyono H. Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells. J Immunol Methods. 1993 Apr 2; 160(2):181-9. PMID: 8459105.
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      391. Fujihashi K, Beagley KW, Kono Y, Aicher WK, Yamamoto M, DiFabio S, Xu-Amano J, McGhee JR, Kiyono H. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol. 1993 Apr; 142(4):1239-50. PMID: 8475996.
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      392. McGhee JR, Kiyono H. New perspectives in vaccine development: mucosal immunity to infections. Infect Agents Dis. 1993 Apr; 2(2):55-73. PMID: 8162356.
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      393. Yamamoto M, Fujihashi K, Beagley KW, McGhee JR, Kiyono H. Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5. J Immunol. 1993 Jan 1; 150(1):106-14. PMID: 8417116.
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      394. Aicher WK, Fujihashi K, Yamamoto M, Kiyono H, Pitts AM, McGhee JR. Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site. Int Immunol. 1992 Sep; 4(9):959-68. PMID: 1390438.
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      395. Fujihashi K, Kono Y, Kiyono H. Effects of IL6 on B cells in mucosal immune response and inflammation. Res Immunol. 1992 Sep; 143(7):744-9. PMID: 1439148.
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      396. Ogawa T, Kusumoto Y, Kiyono H, McGhee JR, Hamada S. Occurrence of antigen-specific B cells following oral or parenteral immunization with Porphyromonas gingivalis fimbriae. Int Immunol. 1992 Sep; 4(9):1003-10. PMID: 1356427.
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      397. McGhee JR, Yamamoto M, Kang DW, Eldridge JH, Mestecky J, Moldoveanu Z, Compans R, Kiyono H, Miller C, Marthas M. Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routes. AIDS Res Hum Retroviruses. 1992 Aug; 8(8):1389. PMID: 1466963.
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      398. Miller CJ, Kang DW, Marthas M, Moldoveanu Z, Kiyono H, Marx P, Eldridge JH, Mestecky J, McGhee JR. Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: a comparison between intravenously and genitally inoculated rhesus macaques. Clin Exp Immunol. 1992 Jun; 88(3):520-6. PMID: 1606737; PMCID: PMC1554514.
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      400. Aicher WK, McGhee ML, McGhee JR, Moldoveanu Z, Kidd VJ, Tomana M, Mestecky J, Eldridge JH, Meyer TF, Kiyono H. Properties of IgA-binding receptors on murine T cells: relative importance of Fc alpha R, beta-galactosyltransferase and anti-secretory component reactive proteins (ASCP). Scand J Immunol. 1992 Apr; 35(4):469-86. PMID: 1557614.
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      401. Mega J, McGhee JR, Kiyono H. Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues. J Immunol. 1992 Apr 1; 148(7):2030-9. PMID: 1545116.
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      402. Kiyono H, Bienenstock J, McGhee JR, Ernst PB. The mucosal immune system: features of inductive and effector sites to consider in mucosal immunization and vaccine development. Reg Immunol. 1992 Mar-Apr; 4(2):54-62. PMID: 1503889.
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      403. Lue C, Kiyono H, Fujihashi K, McGhee JR, Mestecky J. The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigens. Reg Immunol. 1992 Mar-Apr; 4(2):86-90. PMID: 1503891.
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      404. Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone JA, Eldridge JH, Kiyono H. Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. J Exp Med. 1992 Mar 1; 175(3):695-707. PMID: 1531495; PMCID: PMC2119151.
      405. Pascual DW, Bost KL, Xu-Amano J, Kiyono H, McGhee JR. The cytokine-like action of substance P upon B cell differentiation. Reg Immunol. 1992 Mar-Apr; 4(2):100-4. PMID: 1380278.
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      406. Mega J, Fujihashi K, Kiyono H. Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis. Reg Immunol. 1992 Mar-Apr; 4(2):70-8. PMID: 1354470.
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      407. Marthas ML, Miller CJ, Sutjipto S, Higgins J, Torten J, Lohman BL, Unger RE, Ramos RA, Kiyono H, McGhee JR. Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV. J Med Primatol. 1992 Feb-May; 21(2-3):99-107. PMID: 1433273.
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      408. Aicher WK, Fujihashi K, Taguchi T, McGhee JR, Yamamoto M, Eldridge JH, Gay S, Kiyono H. Intestinal intraepithelial lymphocyte T cells are resistant to lpr gene-induced T cell abnormalities. Eur J Immunol. 1992 Jan; 22(1):137-45. PMID: 1346108.
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      409. McGhee JR, Mestecky J, Dertzbaugh MT, Eldridge JH, Hirasawa M, Kiyono H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine. 1992; 10(2):75-88. PMID: 1539467.
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      411. Mega J, Fujihashi K, Yamamoto M, McGhee JR, Hirasawa M, Kiyono H. Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA response. Adv Exp Med Biol. 1992; 327:119-31. PMID: 1295332.
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      412. McGhee JR, Kiyono H. Mucosal immunity to vaccines: current concepts for vaccine development and immune response analysis. Adv Exp Med Biol. 1992; 327:3-12. PMID: 1295349.
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      413. Pascual DW, McGhee JR, Kiyono H, Bost KL. Neuroimmune modulation of lymphocyte function--I. Substance P enhances immunoglobulin synthesis in lipopolysaccharide activated murine splenic B cell cultures. Int Immunol. 1991 Dec; 3(12):1223-9. PMID: 1723293.
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      414. Taguchi T, Aicher WK, Fujihashi K, Yamamoto M, McGhee JR, Bluestone JA, Kiyono H. Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol. 1991 Dec 1; 147(11):3736-44. PMID: 1682383.
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      415. Amano M, Martin JC, McGhee JR, McCutcheon MJ, Kiyono H. Immunofluorescence-digital image processing system for the quantitation of secreted immunoglobulin by single cells. J Immunol Methods. 1991 Nov 5; 144(1):127-40. PMID: 1960401.
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      416. Pascual DW, Bost KL, Xu-Amano J, Kiyono H, McGhee JR. The regulation of antibody responses by mini-cytokines. Acta Neurol (Napoli). 1991 Aug; 13(4):343-9. PMID: 1723564.
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      417. Fujihashi K, McGhee JR, Lue C, Beagley KW, Taga T, Hirano T, Kishimoto T, Mestecky J, Kiyono H. Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis. J Clin Invest. 1991 Jul; 88(1):248-52. PMID: 2056119; PMCID: PMC296026.
      418. Pascual DW, Xu-Amano JC, Kiyono H, McGhee JR, Bost KL. Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production. J Immunol. 1991 Apr 1; 146(7):2130-6. PMID: 1706387.
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      419. Kono Y, Beagley KW, Fujihashi K, McGhee JR, Taga T, Hirano T, Kishimoto T, Kiyono H. Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva. J Immunol. 1991 Mar 15; 146(6):1812-21. PMID: 2005380.
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      420. Beagley KW, Eldridge JH, Aicher WK, Mestecky J, Di Fabio S, Kiyono H, McGhee JR. Peyer's patch B cells with memory cell characteristics undergo terminal differentiation within 24 hours in response to interleukin-6. Cytokine. 1991 Mar; 3(2):107-16. PMID: 1909587.
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      421. Lue C, Kiyono H, McGhee JR, Fujihashi K, Kishimoto T, Hirano T, Mestecky J. Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells. Cell Immunol. 1991 Feb; 132(2):423-32. PMID: 1988161.
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      422. Ogawa T, Kono Y, McGhee ML, McGhee JR, Roberts JE, Hamada S, Kiyono H. Porphyromonas gingivalis-specific serum IgG and IgA antibodies originate from immunoglobulin-secreting cells in inflamed gingiva. Clin Exp Immunol. 1991 Feb; 83(2):237-44. PMID: 1671564; PMCID: PMC1535250.
      423. Kiyono H, Fujihashi K, Taguchi T, Aicher WK, McGhee JR. Regulatory functions for murine intraepithelial lymphocytes in mucosal responses. Immunol Res. 1991; 10(3-4):324-30. PMID: 1955757.
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      424. McGhee JR, Fujihashi K, Beagley KW, Kiyono H. Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses. Immunol Res. 1991; 10(3-4):418-22. PMID: 1955769.
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      425. McGhee JR, Fujihashi K, Lue C, Beagley KW, Mestecky J, Kiyono H. Role of IL-6 in human antigen-specific and polyclonal IgA responses. Adv Exp Med Biol. 1991; 310:113-21. PMID: 1808988.
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      426. Bost KL, Clarke BL, Xu JC, Kiyono H, McGhee JR, Pascual D. Modulation of IgM secretion and H chain mRNA expression in CH12.LX.C4.5F5 B cells by adrenocorticotropic hormone. J Immunol. 1990 Dec 15; 145(12):4326-31. PMID: 2175328.
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      427. Ogawa T, Kusumoto Y, Hamada S, McGhee JR, Kiyono H. Bacteroides gingivalis-specific serum IgG and IgA subclass antibodies in periodontal diseases. Clin Exp Immunol. 1990 Nov; 82(2):318-25. PMID: 1978704; PMCID: PMC1535121.
      428. Fujihashi K, Taguchi T, McGhee JR, Eldridge JH, Bruce MG, Green DR, Singh B, Kiyono H. Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance. J Immunol. 1990 Oct 1; 145(7):2010-9. PMID: 1975820.
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      429. Aicher WK, McGhee ML, McGhee JR, Eldridge JH, Beagley KW, Meyer TF, Kiyono H. Mouse IgA Fc receptor on CD3+ T cells. Molecular forms of IgA that bind to a 38-kDa Fc alpha R protein and development of an anti-Fc alpha R antisera. J Immunol. 1990 Sep 15; 145(6):1745-53. PMID: 2144006.
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      430. Taguchi T, McGhee JR, Coffman RL, Beagley KW, Eldridge JH, Takatsu K, Kiyono H. Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5. J Immunol. 1990 Jul 1; 145(1):68-77. PMID: 1972722.
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      431. Tarkowski A, Lue C, Moldoveanu Z, Kiyono H, McGhee JR, Mestecky J. Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses. J Immunol. 1990 May 15; 144(10):3770-8. PMID: 2110213.
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      432. Taguchi T, McGhee JR, Coffman RL, Beagley KW, Eldridge JH, Takatsu K, Kiyono H. Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J Immunol Methods. 1990 Mar 27; 128(1):65-73. PMID: 2139082.
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      433. Aicher WK, McGhee JR, Kiyono H. Candidates for the mouse Fc alpha R: beta-galactosyl transferase, secretory component and a 38-kDa protein. Res Immunol. 1990 Jan; 141(1):90-4; discussion 105-8. PMID: 2111919.
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      434. Kiyono H, Taguchi T, Aicher WK, Beagley KW, Fujihashi K, Eldridge JH, McGhee JR. Immunoregulatory confluence: T cells, Fc receptors and cytokines for IgA immune responses. Int Rev Immunol. 1990; 6(4):263-73. PMID: 2102907.
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      435. Char D, Aicher WK, McGhee JR, Eldridge JH, Beagley KW, Kiyono H. Induction of Fc alpha receptor expression on T cells from murine Peyer's patch, spleen and thymus. Reg Immunol. 1990-1991; 3(5):228-35. PMID: 2151788.
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      436. Jirillo E, De Simone C, Covelli V, Kiyono H, McGhee JR, Antonaci S. LPS-mediated triggering of T lymphocytes in immune response against gram-negative bacteria. Adv Exp Med Biol. 1990; 256:417-25. PMID: 2183559.
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      437. Fujihashi K, Kiyono H, Aicher WK, Green DR, Singh B, Eldridge JH, McGhee JR. Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance. J Immunol. 1989 Dec 1; 143(11):3415-22. PMID: 2573632.
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      438. Beagley KW, Eldridge JH, Lee F, Kiyono H, Everson MP, Koopman WJ, Hirano T, Kishimoto T, McGhee JR. Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J Exp Med. 1989 Jun 1; 169(6):2133-48. PMID: 2786548; PMCID: PMC2189333.
      439. McGhee JR, Mestecky J, Elson CO, Kiyono H. Regulation of IgA synthesis and immune response by T cells and interleukins. J Clin Immunol. 1989 May; 9(3):175-99. PMID: 2671008.
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      440. Ogawa T, McGhee ML, Moldoveanu Z, Hamada S, Mestecky J, McGhee JR, Kiyono H. Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissues. Clin Exp Immunol. 1989 Apr; 76(1):103-10. PMID: 2567645; PMCID: PMC1541728.
      441. McGhee ML, Ogawa T, Pitts AM, Moldoveanu Z, Mestecky J, McGhee JR, Kiyono H. Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue. Reg Immunol. 1989 Mar-Apr; 2(2):103-10. PMID: 2701813.
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      442. Ogawa T, Tarkowski A, McGhee ML, Moldoveanu Z, Mestecky J, Hirsch HZ, Koopman WJ, Hamada S, McGhee JR, Kiyono H. Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue. J Immunol. 1989 Feb 15; 142(4):1150-8. PMID: 2644350.
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      443. Tarkowski A, Lue C, Moldoveanu Z, Kiyono H, McGhee JR, Prchal JT, Halpern NB, Mestecky J. Systemic immunization for the induction of IgA responses. Curr Top Microbiol Immunol. 1989; 146:161-8. PMID: 2731429.
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      444. Beagley KW, Fujihashi K, Aicher W, Xu J, Kiyono H, Eldridge JH, Bruce MG, Taguchi T, Green DR, Singh B. Mucosal homeostasis: role of interleukins, isotype-specific factors and contrasuppression in the IgA response. Immunol Invest. 1989 Jan-May; 18(1-4):77-89. PMID: 2659524.
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      445. Beagley KW, Eldridge JH, Kiyono H, Everson MP, Koopman WJ, Honjo T, McGhee JR. Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. J Immunol. 1988 Sep 15; 141(6):2035-42. PMID: 3262647.
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      446. McGhee JR, Eldridge JH, Beagley KW, Kiyono H. The possible involvement of CD3+, CD4- and CD8- T cells in immune responses. Ann Inst Pasteur Immunol. 1988 Mar-Apr; 139(2):193-9. PMID: 3259429.
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      447. Kitamura K, Kiyono H, Fujihashi K, Eldrige JH, Beagley KW, McGhee JR. Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses. J Immunol. 1988 Mar 1; 140(5):1385-92. PMID: 2964473.
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      448. Fujihashi K, Kiyono H, Beagley KW, Eldridge JH, McGhee JR. Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation. Adv Exp Med Biol. 1988; 237:649-53. PMID: 2978205.
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      449. Kiyono H, Green DR, McGhee JR. Contrasuppression in the mucosal immune system. Immunol Res. 1988; 7(1):67-81. PMID: 2897412.
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      450. Beagley KW, Eldrigde JH, Kiyono H, McGhee JR. The identification of murine Peyer's patch T cell-derived factors which enhance IgA responses. Adv Exp Med Biol. 1988; 237:641-7. PMID: 3267065.
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      451. Kitamura K, Kiyono H, Fujihashi K, Eldridge JH, Green DR, McGhee JR. Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cells. J Immunol. 1987 Nov 15; 139(10):3251-9. PMID: 3500210.
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      452. Kimura S, Kiyono H, Beagley KW, Torii M, Eldridge JH, Hamada S, Michalek SM, Koopman WJ, McGhee JR. Streptococcal serotype carbohydrate represents a novel class of type 2 antigen which is T-independent. J Immunol. 1987 Jun 15; 138(12):4387-94. PMID: 3495591.
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      453. Kimura S, Kiyono H, Michalek SM, Hamada S, McGhee JR. Haptenated streptococcal antigens elicit either T cell-dependent type 1 or T cell-independent type 2 immune responses. Immunobiology. 1987 Mar; 174(2):146-61. PMID: 3496265.
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      454. McGhee JR, Kiyono H, Michalek SM, Mestecky J. Enteric immunization reveals a T cell network for IgA responses and suggests that humans possess a common mucosal immune system. Antonie Van Leeuwenhoek. 1987; 53(6):537-43. PMID: 3329827.
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      455. Kiyono H, McGhee JR. Mucosal T cell networks: role of Fc alpha R+ T cells and Ig BF alpha in the regulation of the IgA response. Int Rev Immunol. 1987 Jan; 2(2):157-82. PMID: 2906958.
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      456. Kitamura K, Suzuki I, Kiyono H, Kurita T, Berry AK, Green DR, McGhee JR. Isotype-specific immunoregulation: T contrasuppressor cells protect IgA responses in oral tolerance. Adv Exp Med Biol. 1987; 216A:143-8. PMID: 2961203.
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      457. Eldridge JH, Kiyono H, Suzuki I, Kitamura K, Kurita T, Beagley KW, McGhee ML, Michalek SM, Green DR, McGhee JR. Regulatory T cell networks in the secretory immune system. Adv Exp Med Biol. 1987; 216A:45-55. PMID: 2961206.
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      458. Kurita T, Kiyono H, McGhee ML, McGhee JR. Isotype specific immunoregulation: role of Fc alpha R+ T cells and IBF alpha in IgA responses. Adv Exp Med Biol. 1987; 216A:81-7. PMID: 2961213.
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      459. Beagley KW, Kiyono H, Alley CD, Eldridge JH, McGhee JR. Isolation of Peyer's patch T cell subsets involved in isotype specific immunoregulation. Adv Exp Med Biol. 1987; 216A:177-83. PMID: 2825471.
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      460. Scicchitano R, Stanisz AM, Payan DG, Kiyono H, McGhee JR, Bienenstock J. Expression of substance P and somatostatin receptors on a T helper cell line. Adv Exp Med Biol. 1987; 216A:185-90. PMID: 2825472.
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      461. Suzuki I, Kitamura K, Kiyono H, Kurita T, Green DR, McGhee JR. Isotype-specific immunoregulation. Evidence for a distinct subset of T contrasuppressor cells for IgA responses in murine Peyer's patches. J Exp Med. 1986 Aug 1; 164(2):501-16. PMID: 2941516; PMCID: PMC2188238.
      462. Alley CD, Kiyono H, McGhee JR. Murine bone marrow IgA responses to orally administered sheep erythrocytes. J Immunol. 1986 Jun 15; 136(12):4414-9. PMID: 3519768.
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      463. Kurita T, Kiyono H, Komiyama K, Grossi CE, Mestecky J, McGhee JR. Isotype-specific immunoregulation; characterization and function of Fc receptors on T-T hybridomas which produce murine IgA-binding factor. J Immunol. 1986 Jun 1; 136(11):3953-60. PMID: 2939136.
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      464. Suzuki I, Kiyono H, Kitamura K, Green DR, McGhee JR. Abrogation of oral tolerance by contrasuppressor T cells suggests the presence of regulatory T-cell networks in the mucosal immune system. Nature. 1986 Apr 3-9; 320(6061):451-4. PMID: 3485772.
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      465. Kiyono H, Kitamura K, Kurita T, McGhee JR. T cell networks for regulation of the mucosal immune system. Ann Sclavo Collana Monogr. 1986; 3(1-2):65-76. PMID: 3322344.
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      466. Kurita T, Kiyono H, Michalek SM, McGhee JR. An enzyme-linked immunosorbent assay (ELISA) for detection of Fc alpha receptors on isotype-specific T cells. J Immunol Methods. 1985 Dec 27; 85(2):269-77. PMID: 2934484.
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      467. Antonaci S, Jirillo E, Kiyono H, Williamson SI, Michalek SM, McGhee JR. Relationship between immune system and gram-negative bacteria. III. Functional analysis of human peripheral blood lymphocyte subpopulations separated by cytoadherence with Salmonella minnesota Rb. Clin Exp Immunol. 1985 Nov; 62(2):248-55. PMID: 2935333; PMCID: PMC1577436.
      468. Jirillo E, Antonaci S, Kiyono H, Michalek SM, McGhee JR. Relationship between immune system and gram-negative bacteria. IV. T lymphocytes from Lpsd mice possess binding site(s) for Rb Salmonella. J Immunol. 1985 Nov; 135(5):3473-8. PMID: 3876386.
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      469. Kiyono H, Mosteller-Barnum LM, Pitts AM, Williamson SI, Michalek SM, McGhee JR. Isotype-specific immunoregulation. IgA-binding factors produced by Fc alpha receptor-positive T cell hybridomas regulate IgA responses. J Exp Med. 1985 Apr 1; 161(4):731-47. PMID: 2858511; PMCID: PMC2189052.
      470. Eldridge JH, Yaffe LJ, Ryan JJ, Kiyono H, Scher I, McGhee JR. Expression of Lyb-5 and Mls determinants by Peyer's patch B lymphocytes of X-linked immunodeficient mice. J Immunol. 1984 Nov; 133(5):2308-11. PMID: 6332843.
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      471. Kiyono H, Phillips JO, Colwell DE, Michalek SM, Koopman WJ, McGhee JR. Isotype-specificity of helper T cell clones: Fc alpha receptors regulate T and B cell collaboration for IgA responses. J Immunol. 1984 Sep; 133(3):1087-9. PMID: 6235278.
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      472. Jirillo E, Kiyono H, Michalek SM, McGhee JR. Murine immune responses to Salmonella lipopolysaccharide: oral administration of whole bacteria to C3H/HeJ mice induces secondary anti-LPS responses, especially of the IgA isotype. J Immunol. 1984 Apr; 132(4):1702-11. PMID: 6366051.
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      473. Kiyono H, Cooper MD, Kearney JF, Mosteller LM, Michalek SM, Koopman WJ, McGhee JR. Isotype specificity of helper T cell clones. Peyer's patch Th cells preferentially collaborate with mature IgA B cells for IgA responses. J Exp Med. 1984 Mar 1; 159(3):798-811. PMID: 6230414; PMCID: PMC2187251.
      474. McGhee JR, Kiyono H, Alley CD. Gut bacterial endotoxin: influence on gut-associated lymphoreticular tissue and host immune function. Surv Immunol Res. 1984; 3(4):241-52. PMID: 6438750.
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      475. McGhee JR, Michalek SM, Kiyono H, Eldridge JH, Colwell DE, Williamson SI, Wannemuehler MJ, Jirillo E, Mosteller LM, Spalding DM. Mucosal immunoregulation: environmental lipopolysaccharide and GALT T lymphocytes regulate the IgA response. Microbiol Immunol. 1984; 28(3):261-80. PMID: 6234450.
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      476. Kiyono H, Mosteller LM, Eldridge JH, Michalek SM, McGhee JR. IgA responses in xid mice: oral antigen primes Peyer's patch cells for in vitro immune responses and secretory antibody production. J Immunol. 1983 Dec; 131(6):2616-22. PMID: 6227659.
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      477. Michalek SM, Morisaki I, Gregory RL, Kiyono H, Hamada S, McGhee JR. Oral adjuvants enhance IgA responses to Streptococcus mutans. Mol Immunol. 1983 Sep; 20(9):1009-18. PMID: 6358863.
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      478. Michalek SM, McGhee JR, Kiyono H, Colwell DE, Eldridge JH, Wannemuehler MJ, Koopman WJ. The IgA response: inductive aspects, regulatory cells, and effector functions. Ann N Y Acad Sci. 1983 Jun 30; 409:48-71. PMID: 6191614.
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      479. Eldridge JH, Kiyono H, Michalek SM, McGhee JR. Evidence for a mature B cell subpopulation in Peyer's patches of young adult xid mice. J Exp Med. 1983 Feb 1; 157(2):789-94. PMID: 6600493; PMCID: PMC2186945.
      480. Kiyono H, Michalek SM, Mosteller LM, Torii M, Hamada S, McGhee JR. Enhancement of murine immune responses to orally administered haptenated Streptococcus mutans. Scand J Immunol. 1982 Dec; 16(6):455-63. PMID: 6186012.
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      481. Kiyono H, McGhee JR, Mosteller LM, Eldridge JH, Koopman WJ, Kearney JF, Michalek SM. Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses. J Exp Med. 1982 Oct 1; 156(4):1115-30. PMID: 6218215; PMCID: PMC2186816.
      482. Wannemuehler MJ, Kiyono H, Babb JL, Michalek SM, McGhee JR. Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction. J Immunol. 1982 Sep; 129(3):959-65. PMID: 6980928.
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      483. Michalek SM, Kiyono H, Wannemuehler MJ, Mosteller LM, McGhee JR. Lipopolysaccharide (LPS) regulation of the immune response: LPS influence on oral tolerance induction. J Immunol. 1982 May; 128(5):1992-8. PMID: 6460815.
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      484. Kiyono H, McGhee JR, Kearney JF, Michalek SM. Enhancement of in vitro immune responses of murine Peyer's patch cultures by concanavalin A, muramyl dipeptide and lipopolysaccharide. Scand J Immunol. 1982 Apr; 15(4):329-39. PMID: 7048508.
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      485. Kiyono H, McGhee JR, Wannemuehler MJ, Michalek SM. Lack of oral tolerance in C3H/HeJ mice. J Exp Med. 1982 Feb 1; 155(2):605-10. PMID: 7035600; PMCID: PMC2186596.
      486. Frangakis MV, Koopman WJ, Kiyono H, Michalek SM, McGhee JR. An enzymatic method for preparation of dissociated murine Peyer's patch cells enriched for macrophages. J Immunol Methods. 1982; 48(1):33-44. PMID: 7035568.
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      487. Kiyono H, McGhee JR, Wannemuehler MJ, Frangakis MV, Spalding DM, Michalek SM, Koopman WJ. In vivo immune response to a T-cell-dependent antigen by cultures of disassociated murine Peyer's patch. Proc Natl Acad Sci U S A. 1982 Jan; 79(2):596-600. PMID: 6979042; PMCID: PMC345792.
      488. Michalek SM, Hirasawa M, Kiyono H, Ochiai K, McGhee JR. Oral ecology and virulence of Lactobacillus casei and Streptococcus mutans in gnotobiotic rats. Infect Immun. 1981 Sep; 33(3):690-6. PMID: 6793515; PMCID: PMC350763.
      489. Babb JL, Kiyono H, Michalek SM, McGhee JR. LPS regulation of the immune response: suppression of immune responses to orally administered T-independent antigen. J Immunol. 1981 Sep; 127(3):1052-7. PMID: 6167615.
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      490. Hamada S, McGhee JR, Kiyono H, Michalek SM, Yokogawa K, Kawata S. Streptococcus mutans serotype g carbohydrate antigen is a B-cell mitogen. Immunol Lett. 1981 Aug; 3(3):129-32. PMID: 6974686.
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      491. Hamada S, McGhee JR, Kiyono H, Torii M, Michalek SM. Lymphoid cell responses to bacterial cell wall components: mitogenic responses of murine B cells to Streptococcus mutans carbohydrate antigens. J Immunol. 1981 Jun; 126(6):2279-83. PMID: 6262408.
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      492. Sakurai H, Tsuda K, Kiyono S, Masaki K, Kiyono H. [Studies on a new radioimmunoassay kit for glucagon (author's transl)]. Horumon To Rinsho. 1981 Feb; 29(2):271-6. PMID: 7261449.
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      493. Otake S, Hirasawa M, Brown TA, Kawabata Y, Kiyono H, Michalek SM, McGhee JR, Shiota T. Virulence of Streptococcus mutans: characterization of a serotype g antigen-defective mutants and its revertants. Infect Immun. 1981 Jan; 31(1):151-9. PMID: 6452413; PMCID: PMC351764.
      494. Mestecky J, McGhee JR, Crago SS, Jackson S, Kilian M, Kiyono H, Babb JL, Michalek SM. Molecular-cellular interactions in the secretory IgA response. J Reticuloendothel Soc. 1980 Dec; 28(Suppl):45s-60s. PMID: 7003139.
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      495. Michalek SM, Kiyono H, Babb JL, McGhee JR. Inheritance of LPS nonresponsiveness and elevated splenic IgA immune responses in mice orally immunized with heterologous erythrocytes. J Immunol. 1980 Nov; 125(5):2220-4. PMID: 7430625.
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      496. Kiyono H, Babb JL, Michalek SM, McGhee JR. Cellular basis for elevated IgA responses in C3H/HeJ mice. J Immunol. 1980 Aug; 125(2):732-7. PMID: 6967087.
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      497. McGhee JR, Kiyono H, Michalek SM, Babb JL, Rosenstreich DL, Mergenhagen SE. Lipopolysaccharide (LPS) regulation of the immune response: T lymphocytes from normal mice suppress mitogenic and immunogenic responses to LPS. J Immunol. 1980 Apr; 124(4):1603-11. PMID: 6965952.
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      498. Hirasawa M, Kiyono H, Babb JL, Shiota T, Michalek SM, McGhee JR. Virulence of Streptococcus mutans: in vivo reversion of a low-virulence mutant results in partial displacement and pathogenesis. Infect Immun. 1980 Mar; 27(3):1003-11. PMID: 6445879; PMCID: PMC550873.
      499. Hirasawa M, Kiyono H, Shiota T, Hull RA, Curtiss R, Michalek SM, McGhee JR. Virulence of Streptococcus mutans: restoration of pathogenesis of a glucosyltransferase-defective mutant (C4). Infect Immun. 1980 Mar; 27(3):915-21. PMID: 6445880; PMCID: PMC550862.
      500. Hirasawa M, Kiyono H, Shiota T, Michalek SM, McGhee JR. Virulence of Streptococcus mutans: immunochemical characterization of a serotype g-defective mutant (C307). Infect Immun. 1980 Feb; 27(2):697-9. PMID: 7380547; PMCID: PMC550822.
      501. Kiyono H, McGhee JR, Michalek SM. Lipopolysaccharide regulation of the immune response: comparison of responses to LPS in germfree, Escherichia coli-monoassociated and conventional mice. J Immunol. 1980 Jan; 124(1):36-41. PMID: 6985644.
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      502. Otake S, McGhee JR, Hirasawa M, Williams K, Arnold RR, Babb JL, Kiyono H, Cox C, Michalek SM, Shiota T, Ikeda T, Ochiai K. Use of mutants in the elucidation of virulence of Streptococcus mutans. Adv Exp Med Biol. 1978; 107:673-83. PMID: 742506.
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      503. Taminato A, Goto Y, Miyamoto Y, Ikeda M, Kiyono H. [Proceedings: Dynamics of insulin secretion in various diseases, with special reference to a comparison of insulin response to stimulation by glucose, arginine and glucagon]. Nihon Naibunpi Gakkai Zasshi. 1974 Feb 20; 50(2):220. PMID: 4476358.
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      504. Kiyono H, Goto Y, Taminato T, Kurahachi H, Sakurai H. [Proceedings: Pancreatic glucagon response in the arginine stimulation test in endocrine diseases]. Nihon Naibunpi Gakkai Zasshi. 1974 Feb 20; 50(2):248. PMID: 4476374.
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      505. Kurahachi H, Sakurai H, Yoshimi T, Fukase M, Kiyono H. [Proceedings: Effect of glucocorticoids on glucagon secretion]. Nihon Naibunpi Gakkai Zasshi. 1974 Feb 20; 50(2):251. PMID: 4476377.
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      506. Imura H, Kiyono H, Miyamato Y, Goto Y, Sakurai H. [Insulin resistant diabetes]. Nihon Rinsho. 1973 Jul; 31(7):2260-6. PMID: 4795324.
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