Loading...

Hiroshi Kiyono

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0063
La Jolla CA 92093
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Nakahashi-Ouchida R, Yuki Y, Kiyono H. Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases. Hum Vaccin Immunother. 2018 Apr 06; 1-27. PMID: 29624474.
      View in: PubMed
    2. Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing. Int Immunol. 2018 Apr 03; 30(4):141-154. PMID: 29617862.
      View in: PubMed
    3. Hirukawa S, Sagara H, Kaneto S, Kondo T, Kiga K, Sanada T, Kiyono H, Mimuro H. Characterization of morphological conversion of Helicobacter pylori under anaerobic conditions. Microbiol Immunol. 2018 Apr; 62(4):221-228. PMID: 29446491.
      View in: PubMed
    4. Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Sci Transl Med. 2018 Feb 21; 10(429). PMID: 29467297.
      View in: PubMed
    5. Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J. Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. Sci Rep. 2018 Feb 13; 8(1):2904. PMID: 29440671.
      View in: PubMed
    6. Shibata N, Kunisawa J, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K, Kiyono H. Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity. Mucosal Immunol. 2018 Feb 07. PMID: 29411777.
      View in: PubMed
    7. Azegami T, Yuki Y, Hayashi K, Hishikawa A, Sawada SI, Ishige K, Akiyoshi K, Kiyono H, Itoh H. Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents. J Hypertens. 2018 Feb; 36(2):387-394. PMID: 28832363.
      View in: PubMed
    8. Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2017 Dec 27. PMID: 29288079.
      View in: PubMed
    9. Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H. Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System. Front Immunol. 2017; 8:1787. PMID: 29321781.
      View in: PubMed
    10. Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H. A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. Stem Cell Reports. 2018 Jan 09; 10(1):314-328. PMID: 29233552.
      View in: PubMed
    11. Shibata N, Kunisawa J, Kiyono H. Dietary and Microbial Metabolites in the Regulation of Host Immunity. Front Microbiol. 2017; 8:2171. PMID: 29163449.
      View in: PubMed
    12. Azegami T, Yuki Y, Nakahashi R, Itoh H, Kiyono H. Nanogel-based nasal vaccines for infectious and lifestyle-related diseases. Mol Immunol. 2017 Oct 30. PMID: 29096936.
      View in: PubMed
    13. Nakahashi-Ouchida R, Yuki Y, Kiyono H. Development of a nanogel-based nasal vaccine as a novel antigen delivery system. Expert Rev Vaccines. 2017 Dec; 16(12):1231-1240. PMID: 29053938.
      View in: PubMed
    14. Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. J Clin Invest. 2017 Oct 02; 127(10):3784-3795. PMID: 28891812.
      View in: PubMed
    15. Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. IL-22 induces Reg3? and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017 Oct 02; 214(10):3037-3050. PMID: 28811323.
      View in: PubMed
    16. Takahashi Y, Sato S, Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T, Kiyono H. Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells. EBioMedicine. 2017 Sep; 23:34-45. PMID: 28789943.
      View in: PubMed
    17. Ogawa T, Kashima K, Yuki Y, Mejima M, Kurokawa S, Kuroda M, Okazawa A, Kiyono H, Ohta D. Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit. Sci Rep. 2017 Jul 12; 7(1):5196. PMID: 28701756.
      View in: PubMed
    18. Kim SH, Cho BH, Kiyono H, Jang YS. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches. Sci Rep. 2017 Jun 21; 7(1):3980. PMID: 28638068.
      View in: PubMed
    19. Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H. Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Immunity. 2017 05 16; 46(5):863-874.e4. PMID: 28514691.
      View in: PubMed
    20. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med. 2017 Jun 05; 214(6):1607-1618. PMID: 28512157.
      View in: PubMed
    21. Park EJ, Shimaoka M, Kiyono H. MicroRNA-mediated dynamic control of mucosal immunity. Int Immunol. 2017 Apr 01; 29(4):157-163. PMID: 28383678.
      View in: PubMed
    22. Nakajima-Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, Murakami H, Hosono A, Nochi T, Wakatsuki Y, Shimojo N, Kaminogawa S, Sato R, Kiyono H, Hachimura S. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy. PLoS One. 2017; 12(2):e0172795. PMID: 28234975.
      View in: PubMed
    23. Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H. Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nat Commun. 2017 Feb 22; 8:14509. PMID: 28224999.
      View in: PubMed
    24. Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One. 2017; 12(2):e0172509. PMID: 28225814.
      View in: PubMed
    25. Tada R, Muto S, Iwata T, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y. Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice. BMC Res Notes. 2017 Jan 26; 10(1):68. PMID: 28126014.
      View in: PubMed
    26. Kurashima Y, Kiyono H. Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. Annu Rev Immunol. 2017 Apr 26; 35:119-147. PMID: 28125357.
      View in: PubMed
    27. Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R. The spleen is the site where mast cells are induced in the development of food allergy. Int Immunol. 2017 01 01; 29(1):31-45. PMID: 28177443.
      View in: PubMed
    28. Nelson S, Kiyono H, Kurashima Y. Epithelial extracellular ATP: an initiator of immunity to parasitic infections. Immunol Cell Biol. 2017 02; 95(2):117-118. PMID: 27874014.
      View in: PubMed
    29. Goto Y, Uematsu S, Kiyono H. Epithelial glycosylation in gut homeostasis and inflammation. Nat Immunol. 2016 Oct 19; 17(11):1244-1251. PMID: 27760104.
      View in: PubMed
    30. Lee J, Park EJ, Kiyono H. MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation. BMB Rep. 2016 May; 49(5):263-9. PMID: 26923304.
      View in: PubMed
    31. Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF. Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism. Immunity. 2016 Mar 15; 44(3):634-646. PMID: 26982365.
      View in: PubMed
    32. Kogure Y, Kurashima Y, Kiyono H. [MAST CELL MEDIATED HOMEOSTATIC AND BARRIER SYSTEM]. Arerugi. 2016 Mar; 65(2):104-12. PMID: 27086955.
      View in: PubMed
    33. Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H. Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. Regul Toxicol Pharmacol. 2016 Apr; 76:128-36. PMID: 26851506.
      View in: PubMed
    34. Kunisawa J, Kiyono H. Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy. Front Nutr. 2016; 3:3. PMID: 26858949; PMCID: PMC4728802.
    35. Saito S, Ainai A, Suzuki T, Harada N, Ami Y, Yuki Y, Takeyama H, Kiyono H, Tsukada H, Hasegawa H. The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine. Vaccine. 2016 Feb 24; 34(9):1201-7. PMID: 26802605.
      View in: PubMed
    36. Kashima K, Yuki Y, Mejima M, Kurokawa S, Suzuki Y, Minakawa S, Takeyama N, Fukuyama Y, Azegami T, Tanimoto T, Kuroda M, Tamura M, Gomi Y, Kiyono H. Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants. Plant Cell Rep. 2016 Mar; 35(3):667-79. PMID: 26661780.
      View in: PubMed
    37. Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis. Sci Rep. 2015 Dec 09; 5:18174. PMID: 26647826; PMCID: PMC4673535.
    38. Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages. PLoS One. 2015; 10(11):e0142920. PMID: 26575399; PMCID: PMC4648567.
    39. Goto Y, Lamichhane A, Kamioka M, Sato S, Honda K, Kunisawa J, Kiyono H. IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut. Sci Rep. 2015 Nov 02; 5:15918. PMID: 26522513; PMCID: PMC4629126.
    40. Tada R, Hidaka A, Iwase N, Takahashi S, Yamakita Y, Iwata T, Muto S, Sato E, Takayama N, Honjo E, Kiyono H, Kunisawa J, Aramaki Y. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice. PLoS One. 2015; 10(10):e0139785. PMID: 26440657; PMCID: PMC4594917.
    41. Goto Y, Kurashima Y, Kiyono H. [Roles of the gut mucosal immune system in symbiosis and immunity]. Rinsho Ketsueki. 2015 Oct; 56(10):2205-12. PMID: 26458461.
      View in: PubMed
    42. Fukuyama Y, Okada K, Yamaguchi M, Kiyono H, Mori K, Yuki Y. Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice. PLoS One. 2015; 10(9):e0139368. PMID: 26422280; PMCID: PMC4589288.
    43. Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M, Kiyono H. Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1. Cell Rep. 2015 Oct 06; 13(1):122-131. PMID: 26411688.
      View in: PubMed
    44. Takeyama N, Kiyono H, Yuki Y. Plant-based vaccines for animals and humans: recent advances in technology and clinical trials. Ther Adv Vaccines. 2015 Sep; 3(5-6):139-54. PMID: 26668752.
      View in: PubMed
    45. Takeyama N, Yuki Y, Tokuhara D, Oroku K, Mejima M, Kurokawa S, Kuroda M, Kodama T, Nagai S, Ueda S, Kiyono H. Oral rice-based vaccine induces passive and active immunity against enterotoxigenic E. coli-mediated diarrhea in pigs. Vaccine. 2015 Sep 22; 33(39):5204-11. PMID: 26254309.
      View in: PubMed
    46. Park EJ, Yuki Y, Kiyono H, Shimaoka M. Structural basis of blocking integrin activation and deactivation for anti-inflammation. J Biomed Sci. 2015 Jul 08; 22:51. PMID: 26152212; PMCID: PMC4495637.
    47. Goto Y, Kurashima Y, Kiyono H. The gut microbiota and inflammatory bowel disease. Curr Opin Rheumatol. 2015 Jul; 27(4):388-96. PMID: 26002031.
      View in: PubMed
    48. Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. Dietary ?3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep. 2015 Jun 11; 5:9750. PMID: 26065911; PMCID: PMC4464255.
    49. Suzuki H, Watari A, Hashimoto E, Yonemitsu M, Kiyono H, Yagi K, Kondoh M, Kunisawa J. C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine. PLoS One. 2015; 10(5):e0126352. PMID: 26018248; PMCID: PMC4446347.
    50. Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H. Central Role of Core Binding Factor ß2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. PLoS One. 2015; 10(5):e0127460. PMID: 26001080; PMCID: PMC4441428.
    51. Kurashima Y, Kiyono H, Kunisawa J. Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation. Mediators Inflamm. 2015; 2015:427125. PMID: 25944982; PMCID: PMC4405224.
    52. Kishida K, Kohyama M, Kurashima Y, Kogure Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H. Negative regulation of DSS-induced experimental colitis by PILRa. Int Immunol. 2015 Jun; 27(6):307-14. PMID: 25710489.
      View in: PubMed
    53. Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K. The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015 Feb 17; 42(2):279-293. PMID: 25692702.
      View in: PubMed
    54. Kashima K, Mejima M, Kurokawa S, Kuroda M, Kiyono H, Yuki Y. Comparative whole-genome analyses of selection marker-free rice-based cholera toxin B-subunit vaccine lines and wild-type lines. BMC Genomics. 2015 Feb 05; 16:48. PMID: 25653106; PMCID: PMC4320824.
    55. Kunisawa J, Kiyono H. Vitamins mediate immunological homeostasis and diseases at the surface of the body. Endocr Metab Immune Disord Drug Targets. 2015; 15(1):25-30. PMID: 25335990.
      View in: PubMed
    56. Kiyono H, Azegami T. The mucosal immune system: From dentistry to vaccine development. Proc Jpn Acad Ser B Phys Biol Sci. 2015; 91(8):423-39. PMID: 26460320; PMCID: PMC4729857.
    57. Sato S, Kiyono H, Fujihashi K. Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review. Gerontology. 2015; 61(4):336-42. PMID: 25531743; PMCID: PMC4475504.
    58. Kurashima Y, Kiyono H, Kunisawa J. [Purinergic signaling mediates mast cell activation in intestinal inflammation]. Seikagaku. 2014 Dec; 86(6):798-802. PMID: 25675821.
      View in: PubMed
    59. Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K. Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease. J Immunol. 2015 Jan 01; 194(1):398-406. PMID: 25422510.
      View in: PubMed
    60. Nakajima-Adachi H, Kikuchi A, Fujimura Y, Shibahara K, Makino T, Goseki-Sone M, Kihara-Fujioka M, Nochi T, Kurashima Y, Igarashi O, Yamamoto M, Kunisawa J, Toda M, Kaminogawa S, Sato R, Kiyono H, Hachimura S. Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy. PLoS One. 2014; 9(10):e107492. PMID: 25290461; PMCID: PMC4188560.
    61. Okura H, Sato S, Kishikawa S, Kaneto S, Nakashima T, Yoshida N, Takayanagi H, Kiyono H. Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. PLoS One. 2014; 9(9):e108294. PMID: 25244033; PMCID: PMC4171521.
    62. Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H. Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol. 2014 Dec; 88(23):13699-708. PMID: 25231301; PMCID: PMC4248987.
    63. Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science. 2014 Sep 12; 345(6202):1254009. PMID: 25214634; PMCID: PMC4774895.
    64. Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H. Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. J Immunol. 2014 Aug 15; 193(4):1666-71. PMID: 25031459.
      View in: PubMed
    65. Azegami T, Itoh H, Kiyono H, Yuki Y. Novel transgenic rice-based vaccines. Arch Immunol Ther Exp (Warsz). 2015 Apr; 63(2):87-99. PMID: 25027548.
      View in: PubMed
    66. Azegami T, Yuki Y, Kiyono H. Challenges in mucosal vaccines for the control of infectious diseases. Int Immunol. 2014 Sep; 26(9):517-28. PMID: 24914172.
      View in: PubMed
    67. Tokuhara D, Nochi T, Matsumura A, Mejima M, Takahashi Y, Kurokawa S, Kiyono H, Yuki Y. Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine. Dig Dis Sci. 2014 Nov; 59(11):2682-92. PMID: 24838500.
      View in: PubMed
    68. Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T. Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice. Inflamm Bowel Dis. 2014 May; 20(5):790-9. PMID: 24651581.
      View in: PubMed
    69. Kurashima Y, Amiya T, Fujisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. Immunity. 2014 Apr 17; 40(4):530-41. PMID: 24726878.
      View in: PubMed
    70. Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 2014 Apr 10; 5:3704. PMID: 24718324.
      View in: PubMed
    71. Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 2014 Mar 18; 5:3492. PMID: 24637670; PMCID: PMC3959210.
    72. Kotani Y, Kunisawa J, Suzuki Y, Sato I, Saito T, Toba M, Kohda N, Kiyono H. Role of Lactobacillus pentosus Strain b240 and the Toll-like receptor 2 axis in Peyer's patch dendritic cell-mediated immunoglobulin A enhancement. PLoS One. 2014; 9(3):e91857. PMID: 24632732; PMCID: PMC3954862.
    73. Kurashima Y, Kiyono H. New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development. Exp Mol Med. 2014 Mar 14; 46:e83. PMID: 24626169; PMCID: PMC3972796.
    74. Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H. A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. J Biotechnol. 2014 Apr 10; 175:45-52. PMID: 24548461.
      View in: PubMed
    75. Fujihashi K, Sato S, Kiyono H. Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. Exp Gerontol. 2014 Jun; 54:21-6. PMID: 24440991; PMCID: PMC3989367.
    76. Suzuki H, Kondoh M, Yagi K, Kiyono H, Kunisawa J. [The development of mucosal vaccine using bacterial function for targeting mucosal tissues]. Yakugaku Zasshi. 2014; 134(5):629-34. PMID: 24790045.
      View in: PubMed
    77. Korneychuk N, Ramiro-Puig E, Ettersperger J, Schulthess J, Montcuquet N, Kiyono H, Meresse B, Cerf-Bensussan N. Interleukin 15 and CD4? T cells cooperate to promote small intestinal enteropathy in response to dietary antigen. Gastroenterology. 2014 Apr; 146(4):1017-27. PMID: 24361466.
      View in: PubMed
    78. Lamichhane A, Kiyono H, Kunisawa J. Nutritional components regulate the gut immune system and its association with intestinal immune disease development. J Gastroenterol Hepatol. 2013 Dec; 28 Suppl 4:18-24. PMID: 24251698.
      View in: PubMed
    79. Kurashima Y, Goto Y, Kiyono H. Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur J Immunol. 2013 Dec; 43(12):3108-15. PMID: 24414823.
      View in: PubMed
    80. Kishino S, Takeuchi M, Park SB, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17808-13. PMID: 24127592; PMCID: PMC3816446.
    81. Kurokawa S, Kuroda M, Mejima M, Nakamura R, Takahashi Y, Sagara H, Takeyama N, Satoh S, Kiyono H, Teshima R, Masumura T, Yuki Y. RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds. Plant Cell Rep. 2014 Jan; 33(1):75-87. PMID: 24085308.
      View in: PubMed
    82. Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. PLoS One. 2013; 8(8):e72050. PMID: 23951282; PMCID: PMC3741198.
    83. Tokuhara D, Álvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, Kuroda M, Oyama M, Kozuka-Hata H, Nochi T, Sagara H, Aladin F, Marcotte H, Frenken LG, Iturriza-Gómara M, Kiyono H, Hammarström L, Yuki Y. Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest. 2013 Sep; 123(9):3829-38. PMID: 23925294; PMCID: PMC3754275.
    84. Kunisawa J, Kiyono H. Vitamin-mediated regulation of intestinal immunity. Front Immunol. 2013; 4:189. PMID: 23874335; PMCID: PMC3708512.
    85. Kurokawa S, Nakamura R, Mejima M, Kozuka-Hata H, Kuroda M, Takeyama N, Oyama M, Satoh S, Kiyono H, Masumura T, Teshima R, Yuki Y. MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of a-amylase/trypsin inhibitor-like protein family as major rice allergens. J Proteome Res. 2013 Jul 05; 12(7):3372-82. PMID: 23763241.
      View in: PubMed
    86. Obata T, Shibata N, Goto Y, Ishikawa I, Sato S, Kunisawa J, Kiyono H. Critical role of dendritic cells in T cell retention in the interfollicular region of Peyer's patches. J Immunol. 2013 Jul 15; 191(2):942-8. PMID: 23772027.
      View in: PubMed
    87. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Takahashi Y, Tokuhara D, Nochi T, Katakai Y, Kuroda M, Takeyama N, Kashima K, Abe M, Chen Y, Nakanishi U, Masumura T, Takeuchi Y, Kozuka-Hata H, Shibata H, Oyama M, Tanaka K, Kiyono H. Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol J. 2013 Sep; 11(7):799-808. PMID: 23601492.
      View in: PubMed
    88. Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert RS, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee JR, Fujihashi K. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One. 2013; 8(4):e60453. PMID: 23565250; PMCID: PMC3615010.
    89. Kong IG, Sato A, Yuki Y, Nochi T, Takahashi H, Sawada S, Mejima M, Kurokawa S, Okada K, Sato S, Briles DE, Kunisawa J, Inoue Y, Yamamoto M, Akiyoshi K, Kiyono H. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun. 2013 May; 81(5):1625-34. PMID: 23460513; PMCID: PMC3647999.
    90. Kunisawa J, Gohda M, Hashimoto E, Ishikawa I, Higuchi M, Suzuki Y, Goto Y, Panea C, Ivanov II, Sumiya R, Aayam L, Wake T, Tajiri S, Kurashima Y, Shikata S, Akira S, Takeda K, Kiyono H. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun. 2013; 4:1772. PMID: 23612313; PMCID: PMC3644083.
    91. Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun. 2013; 4:1949. PMID: 23752491.
      View in: PubMed
    92. Yuki Y, Nochi T, Kong IG, Takahashi H, Sawada S, Akiyoshi K, Kiyono H. Nanogel-based antigen-delivery system for nasal vaccines. Biotechnol Genet Eng Rev. 2013; 29:61-72. PMID: 24568253.
      View in: PubMed
    93. Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K. Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol. 2013 Jan 15; 190(2):774-83. PMID: 23241884; PMCID: PMC3539688.
    94. Nakajima-Adachi H, Koike E, Totsuka M, Hiraide E, Wakatsuki Y, Kiyono H, Hachimura S. Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4?T cells into the Th2 or Th1 phenotype. Biosci Biotechnol Biochem. 2012; 76(10):1979-81. PMID: 23047087.
      View in: PubMed
    95. Kumagai T, Kiyono H. Summary for symposium I on the development of a more efficacious influenza vaccine held at the 15th Annual Meeting of the Japanese Society for Vaccinology, Tokyo, 2011. Vaccine. 2012 Sep 28; 30(44):6338-9. PMID: 22906723.
      View in: PubMed
    96. Kunisawa J, Kiyono H. Immune regulation and monitoring at the epithelial surface of the intestine. Drug Discov Today. 2013 Jan; 18(1-2):87-92. PMID: 22897879.
      View in: PubMed
    97. Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K. Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol. 2012 Sep 15; 189(6):2869-78. PMID: 22869901.
      View in: PubMed
    98. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K. PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 2012 Oct; 24(10):613-23. PMID: 22836022.
      View in: PubMed
    99. Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 2012 Jun 08; 336(6086):1321-5. PMID: 22674331; PMCID: PMC3659421.
    100. Jeon SG, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, Tsuji NM, Kiyono H, Ma JS, Kusu T, Okumura R, Hara H, Yoshida H, Yamamoto M, Nomoto K, Takeda K. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog. 2012; 8(5):e1002714. PMID: 22693446; PMCID: PMC3364948.
    101. Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice. J Immunol. 2012 Jun 15; 188(12):6145-55. PMID: 22611244; PMCID: PMC3370073.
    102. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Kong IG, Kuroda M, Takahashi Y, Nochi T, Tokuhara D, Kohda T, Kozaki S, Kiyono H. RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine. Vaccine. 2012 Jun 13; 30(28):4160-6. PMID: 22554467.
      View in: PubMed
    103. Sato S, Kiyono H. The mucosal immune system of the respiratory tract. Curr Opin Virol. 2012 Jun; 2(3):225-32. PMID: 22542216.
      View in: PubMed
    104. Kunisawa J, Kiyono H. Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses. Front Immunol. 2012; 3:65. PMID: 22566946; PMCID: PMC3342267.
    105. Kunisawa J, Kiyono H. Immunological function of sphingosine 1-phosphate in the intestine. Nutrients. 2012 03; 4(3):154-66. PMID: 22666543; PMCID: PMC3347024.
    106. Fujkuyama Y, Tokuhara D, Kataoka K, Gilbert RS, McGhee JR, Yuki Y, Kiyono H, Fujihashi K. Novel vaccine development strategies for inducing mucosal immunity. Expert Rev Vaccines. 2012 Mar; 11(3):367-79. PMID: 22380827; PMCID: PMC3315788.
    107. Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 2012; 7(2):e32094. PMID: 22363800; PMCID: PMC3282783.
    108. Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood. 2012 Mar 22; 119(12):2768-77. PMID: 22279057; PMCID: PMC3327455.
    109. Goto Y, Kiyono H. Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol Rev. 2012 Jan; 245(1):147-63. PMID: 22168418.
      View in: PubMed
    110. Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun. 2012; 3:1034. PMID: 22948816; PMCID: PMC3658010.
    111. Kiyono H, Okada K. [Mucosal immune systems--frontline of the biological defence mechanism]. Nihon Jibiinkoka Gakkai Kaiho. 2011 Nov; 114(11):843-50. PMID: 22295432.
      View in: PubMed
    112. Kim SH, Jung DI, Yang IY, Kim J, Lee KY, Nochi T, Kiyono H, Jang YS. M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery. Eur J Immunol. 2011 Nov; 41(11):3219-29. PMID: 21887786.
      View in: PubMed
    113. Takeyama N, Yuki Y, Kiyono H. [Current progress in the development of mucosal vaccines]. Nihon Rinsho. 2011 Sep; 69(9):1555-60. PMID: 21922752.
      View in: PubMed
    114. Okada K, Yamasoba T, Kiyono H. Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine. Adv Otorhinolaryngol. 2011; 72:31-6. PMID: 21865684.
      View in: PubMed
    115. Stappenbeck T, Kiyono H. Host pathogens. Editorial overview. Curr Opin Immunol. 2011 Aug; 23(4):445-7. PMID: 21856138.
      View in: PubMed
    116. Kunisawa J, Kurashima Y, Kiyono H. Gut-associated lymphoid tissues for the development of oral vaccines. Adv Drug Deliv Rev. 2012 May 01; 64(6):523-30. PMID: 21827802.
      View in: PubMed
    117. Burggraf M, Nakajima-Adachi H, Hachimura S, Ilchmann A, Pemberton AD, Kiyono H, Vieths S, Toda M. Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy. Mol Nutr Food Res. 2011 Oct; 55(10):1475-83. PMID: 21714123.
      View in: PubMed
    118. Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011 May 19; 9(5):376-89. PMID: 21575909.
      View in: PubMed
    119. Goto Y, Kiyono H. Epithelial cell microRNAs in gut immunity. Nat Immunol. 2011 Mar; 12(3):195-7. PMID: 21321589.
      View in: PubMed
    120. Kim DY, Sato A, Fukuyama S, Sagara H, Nagatake T, Kong IG, Goda K, Nochi T, Kunisawa J, Sato S, Yokota Y, Lee CH, Kiyono H. The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J Immunol. 2011 Apr 01; 186(7):4253-62. PMID: 21357262.
      View in: PubMed
    121. Kunisawa J, Kiyono H. Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. Cell Host Microbe. 2011 Feb 17; 9(2):83-4. PMID: 21320688.
      View in: PubMed
    122. Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H. Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun. 2011 Jan 21; 404(3):822-8. PMID: 21172308.
      View in: PubMed
    123. Takahashi I, Fujihashi K, Kiyono H. Mucosal regulatory cells in the gastrointestinal tract and periodontium. Periodontol 2000. 2010 Oct; 54(1):247-56. PMID: 20712644.
      View in: PubMed
    124. Yuki Y, Nochi T, Harada N, Katakai Y, Shibata H, Mejima M, Kohda T, Tokuhara D, Kurokawa S, Takahashi Y, Ono F, Kozaki S, Terao K, Tsukada H, Kiyono H. In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates. J Immunol. 2010 Nov 01; 185(9):5436-43. PMID: 20881188.
      View in: PubMed
    125. Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010 Dec; 84(24):12703-12. PMID: 20881038; PMCID: PMC3004317.
    126. Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K. High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. J Biol Chem. 2010 Oct 01; 285(40):30427-35. PMID: 20663890; PMCID: PMC2945535.
    127. Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H. Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater. 2010 Jul; 9(7):572-8. PMID: 20562880.
      View in: PubMed
    128. Malamut G, El Machhour R, Montcuquet N, Martin-Lannerée S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest. 2010 Jun; 120(6):2131-43. PMID: 20440074; PMCID: PMC2877946.
    129. Kunisawa J, Kiyono H. Aberrant interaction of the gut immune system with environmental factors in the development of food allergies. Curr Allergy Asthma Rep. 2010 May; 10(3):215-21. PMID: 20424996.
      View in: PubMed
    130. Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H. Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8794-9. PMID: 20421480; PMCID: PMC2889329.
    131. Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7419-24. PMID: 20360558; PMCID: PMC2867693.
    132. Fuglem B, Jirillo E, Bjerkås I, Kiyono H, Nochi T, Yuki Y, Raida M, Fischer U, Koppang EO. Antigen-sampling cells in the salmonid intestinal epithelium. Dev Comp Immunol. 2010 Jul; 34(7):768-74. PMID: 20178814.
      View in: PubMed
    133. Umehara T, Udagawa J, Takamura K, Kimura M, Ishimitsu R, Kiyono H, Kawauchi H, Otani H. Role of interleukin-15 in the development of mouse olfactory nerve. Congenit Anom (Kyoto). 2009 Dec; 49(4):253-7. PMID: 20021484.
      View in: PubMed
    134. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 2009 Nov 12; 462(7270):226-30. PMID: 19907495.
      View in: PubMed
    135. Sato A, Kiyono H. [The mucosal immune system: new strategy for the control of allergic diseases]. Nihon Rinsho. 2009 Nov; 67(11):2194-9. PMID: 19899540.
      View in: PubMed
    136. Nochi T, Yuki Y, Katakai Y, Shibata H, Tokuhara D, Mejima M, Kurokawa S, Takahashi Y, Nakanishi U, Ono F, Mimuro H, Sasakawa C, Takaiwa F, Terao K, Kiyono H. A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity. J Immunol. 2009 Nov 15; 183(10):6538-44. PMID: 19880451.
      View in: PubMed
    137. Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR. RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J Immunol. 2009 Nov 01; 183(9):5738-47. PMID: 19828638; PMCID: PMC2922944.
    138. Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 2009 Oct 26; 206(11):2351-64. PMID: 19822644; PMCID: PMC2768868.
    139. Suzuki R, Nourani MR, Saino-Saito S, Abe H, Nochi T, Kiyono H, Spener F, Kondo H, Owada Y. Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine. Histochem Cell Biol. 2009 Dec; 132(6):577-84. PMID: 19787366.
      View in: PubMed
    140. Yuki Y, Tokuhara D, Nochi T, Yasuda H, Mejima M, Kurokawa S, Takahashi Y, Kataoka N, Nakanishi U, Hagiwara Y, Fujihashi K, Takaiwa F, Kiyono H. Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine. 2009 Oct 09; 27(43):5982-8. PMID: 19665603.
      View in: PubMed
    141. Yuki Y, Kiyono H. Mucosal vaccines: novel advances in technology and delivery. Expert Rev Vaccines. 2009 Aug; 8(8):1083-97. PMID: 19627189.
      View in: PubMed
    142. Fujihashi K, Kiyono H. Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends Immunol. 2009 Jul; 30(7):334-43. PMID: 19540811.
      View in: PubMed
    143. Takahashi I, Nochi T, Yuki Y, Kiyono H. New horizon of mucosal immunity and vaccines. Curr Opin Immunol. 2009 Jun; 21(3):352-8. PMID: 19493665.
      View in: PubMed
    144. Nochi T, Kiyono H. [Recent progress for the development of mucosal vaccine]. Tanpakushitsu Kakusan Koso. 2009 Jun; 54(8 Suppl):1089-95. PMID: 21089546.
      View in: PubMed
    145. Kim D, Kim SH, Park EJ, Kim J, Cho SH, Kagawa J, Arai N, Jun K, Kiyono H, Kim S. Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta. Int Arch Allergy Immunol. 2009; 150(2):164-71. PMID: 19439982.
      View in: PubMed
    146. Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun. 2009 Jun 05; 383(3):340-6. PMID: 19358828.
      View in: PubMed
    147. Kunisawa J, Nochi T, Kiyono H. Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol. 2008 Nov; 29(11):505-13. PMID: 18835748.
      View in: PubMed
    148. Fehervari Z, Kiyono H. The mucosa: at the frontlines of immunity. Trends Immunol. 2008 Nov; 29(11):503-4. PMID: 18838300.
      View in: PubMed
    149. Mestecky J, Nguyen H, Czerkinsky C, Kiyono H. Oral immunization: an update. Curr Opin Gastroenterol. 2008 Nov; 24(6):713-9. PMID: 19122521.
      View in: PubMed
    150. Yuki Y, Kiyono H. [MucoRice: development of rice-based oral vaccine]. Nihon Rinsho Meneki Gakkai Kaishi. 2008 Oct; 31(5):369-74. PMID: 18974620.
      View in: PubMed
    151. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 2008 Jun 15; 180(12):7840-6. PMID: 18523247.
      View in: PubMed
    152. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 2008 Jul; 9(7):769-76. PMID: 18516037.
      View in: PubMed
    153. Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice. Int Immunol. 2008 Jul; 20(7):881-91. PMID: 18492657.
      View in: PubMed
    154. Ooi EL, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol. 2008; 32(10):1211-20. PMID: 18466972.
      View in: PubMed
    155. Caipang CM, Verjan N, Ooi EL, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis. Fish Shellfish Immunol. 2008 Sep; 25(3):315-20. PMID: 18603448.
      View in: PubMed
    156. Verjan N, Ooi EL, Nochi T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2008 Jul; 25(1-2):170-80. PMID: 18499475.
      View in: PubMed
    157. Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol. 2008 Apr 15; 180(8):5335-43. PMID: 18390715.
      View in: PubMed
    158. Momoi F, Hashizume T, Kurita-Ochiai T, Yuki Y, Kiyono H, Yamamoto M. Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies. Infect Immun. 2008 Jun; 76(6):2777-84. PMID: 18411288; PMCID: PMC2423079.
    159. Chang SY, Cha HR, Igarashi O, Rennert PD, Kissenpfennig A, Malissen B, Nanno M, Kiyono H, Kweon MN. Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. J Immunol. 2008 Apr 01; 180(7):4361-5. PMID: 18354155.
      View in: PubMed
    160. Kunisawa J, Gohda M, Kurashima Y, Ishikawa I, Higuchi M, Kiyono H. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. Blood. 2008 May 01; 111(9):4646-52. PMID: 18292290.
      View in: PubMed
    161. Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol. 2008 Feb 01; 180(3):1609-18. PMID: 18209057.
      View in: PubMed
    162. Kurashima Y, Kunisawa J, Kiyono H. [Applicable strategies for the mucosal immune system in the regulation of allergic diseases]. Arerugi. 2008 Feb; 57(2):87-94. PMID: 18349582.
      View in: PubMed
    163. Hashizume T, Togawa A, Nochi T, Igarashi O, Kweon MN, Kiyono H, Yamamoto M. Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp. Infect Immun. 2008 Mar; 76(3):927-34. PMID: 18086815; PMCID: PMC2258839.
    164. Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, Kim DY, Fukuyama S, Iwatsuki-Horimoto K, Kawaoka Y, Kohda T, Kozaki S, Igarashi O, Kiyono H. A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med. 2007 Nov 26; 204(12):2789-96. PMID: 17984304; PMCID: PMC2118513.
    165. Takamura K, Fukuyama S, Nagatake T, Kim DY, Kawamura A, Kawauchi H, Kiyono H. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 2007 Nov 01; 179(9):5897-906. PMID: 17947663.
      View in: PubMed
    166. Ooi EL, Verjan N, Hirono I, Nochi T, Kondo H, Aoki T, Kiyono H, Yuki Y. Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli. Fish Shellfish Immunol. 2008 May; 24(5):506-13. PMID: 18329900.
      View in: PubMed
    167. Kunisawa J, Kurashima Y, Higuchi M, Gohda M, Ishikawa I, Ogahara I, Kim N, Shimizu M, Kiyono H. Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med. 2007 Oct 01; 204(10):2335-48. PMID: 17875673; PMCID: PMC2118459.
    168. Kurashima Y, Kunisawa J, Higuchi M, Gohda M, Ishikawa I, Takayama N, Shimizu M, Kiyono H. Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. J Immunol. 2007 Aug 01; 179(3):1577-85. PMID: 17641024.
      View in: PubMed
    169. Yuki Y, Nochi T, Kiyono H. Progress towards an AIDS mucosal vaccine: an overview. Tuberculosis (Edinb). 2007 Aug; 87 Suppl 1:S35-44. PMID: 17652028.
      View in: PubMed
    170. Nochi T, Takagi H, Yuki Y, Yang L, Masumura T, Mejima M, Nakanishi U, Matsumura A, Uozumi A, Hiroi T, Morita S, Tanaka K, Takaiwa F, Kiyono H. Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10986-91. PMID: 17573530; PMCID: PMC1904174.
    171. Ohka S, Igarashi H, Nagata N, Sakai M, Koike S, Nochi T, Kiyono H, Nomoto A. Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. J Virol. 2007 Aug; 81(15):7902-12. PMID: 17507470; PMCID: PMC1951287.
    172. Nagai S, Mimuro H, Yamada T, Baba Y, Moro K, Nochi T, Kiyono H, Suzuki T, Sasakawa C, Koyasu S. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8971-6. PMID: 17502608; PMCID: PMC1885612.
    173. Tamagawa H, Hiroi T, Mizushima T, Ito T, Matsuda H, Kiyono H. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis. Inflamm Bowel Dis. 2007 May; 13(5):547-56. PMID: 17245768.
      View in: PubMed
    174. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007 Apr 15; 178(8):4937-46. PMID: 17404275.
      View in: PubMed
    175. Fukuyama S, Kiyono H. Neuroregulator RET initiates Peyer's-patch tissue genesis. Immunity. 2007 Apr; 26(4):393-5. PMID: 17459808.
      View in: PubMed
    176. Takayama N, Igarashi O, Kweon MN, Kiyono H. Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea. Clin Immunol. 2007 May; 123(2):199-208. PMID: 17360239.
      View in: PubMed
    177. McGhee JR, Kunisawa J, Kiyono H. Gut lymphocyte migration: we are halfway 'home'. Trends Immunol. 2007 Apr; 28(4):150-3. PMID: 17293162.
      View in: PubMed
    178. Kunisawa J, Gohda M, Kiyono H. [Uniqueness of the mucosal immune system for the development of prospective mucosal vaccine]. Yakugaku Zasshi. 2007 Feb; 127(2):319-26. PMID: 17268152.
      View in: PubMed
    179. Kunisawa J, Takahashi I, Kiyono H. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev. 2007 Feb; 215:136-53. PMID: 17291285.
      View in: PubMed
    180. Kunisawa J, Kurashima Y, Gohda M, Higuchi M, Ishikawa I, Miura F, Ogahara I, Kiyono H. Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. Blood. 2007 May 01; 109(9):3749-56. PMID: 17234743.
      View in: PubMed
    181. Kim N, Kunisawa J, Kweon MN, Eog Ji G, Kiyono H. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin Immunol. 2007 Apr; 123(1):30-9. PMID: 17218154.
      View in: PubMed
    182. Tanaka N, Fukuyama S, Fukuiwa T, Kawabata M, Sagara Y, Ito HO, Miwa Y, Nagatake T, Kiyono H, Kurono Y. Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine. 2007 Mar 30; 25(14):2680-7. PMID: 17270319.
      View in: PubMed
    183. Maddaloni M, Staats HF, Mierzejewska D, Hoyt T, Robinson A, Callis G, Kozaki S, Kiyono H, McGhee JR, Fujihashi K, Pascual DW. Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. J Immunol. 2006 Oct 15; 177(8):5524-32. PMID: 17015739.
      View in: PubMed
    184. Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H. Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J Immunol. 2006 Oct 01; 177(7):4276-80. PMID: 16982861.
      View in: PubMed
    185. Hagiwara Y, Kawamura YI, Kataoka K, Rahima B, Jackson RJ, Komase K, Dohi T, Boyaka PN, Takeda Y, Kiyono H, McGhee JR, Fujihashi K. A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking. J Immunol. 2006 Sep 01; 177(5):3045-54. PMID: 16920941; PMCID: PMC4469177.
    186. Duverger A, Jackson RJ, van Ginkel FW, Fischer R, Tafaro A, Leppla SH, Fujihashi K, Kiyono H, McGhee JR, Boyaka PN. Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J Immunol. 2006 Feb 01; 176(3):1776-83. PMID: 16424208.
      View in: PubMed
    187. Jang MH, Sougawa N, Tanaka T, Hirata T, Hiroi T, Tohya K, Guo Z, Umemoto E, Ebisuno Y, Yang BG, Seoh JY, Lipp M, Kiyono H, Miyasaka M. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol. 2006 Jan 15; 176(2):803-10. PMID: 16393963.
      View in: PubMed
    188. Nochi T, Kiyono H. Innate immunity in the mucosal immune system. Curr Pharm Des. 2006; 12(32):4203-13. PMID: 17100623.
      View in: PubMed
    189. Yuki Y, Hara-Yakoyama C, Guadiz AA, Udaka S, Kiyono H, Chatterjee S. Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes. Biotechnol Bioeng. 2005 Dec 30; 92(7):803-9. PMID: 16142801.
      View in: PubMed
    190. Takagi H, Hiroi T, Yang L, Tada Y, Yuki Y, Takamura K, Ishimitsu R, Kawauchi H, Kiyono H, Takaiwa F. A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17525-30. PMID: 16278301; PMCID: PMC1297655.
    191. Kunisawa J, Fukuyama S, Kiyono H. Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Curr Mol Med. 2005 Sep; 5(6):557-72. PMID: 16178767.
      View in: PubMed
    192. Ohmura M, Yamamoto M, Tomiyama-Miyaji C, Yuki Y, Takeda Y, Kiyono H. Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation. Infect Immun. 2005 Jul; 73(7):4088-97. PMID: 15972497; PMCID: PMC1168555.
    193. Hino A, Fukuyama S, Kataoka K, Kweon MN, Fujihashi K, Kiyono H. Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea. J Immunol. 2005 Jun 01; 174(11):7423-32. PMID: 15905591.
      View in: PubMed
    194. Ueta M, Hamuro J, Kiyono H, Kinoshita S. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005 May 27; 331(1):285-94. PMID: 15845391.
      View in: PubMed
    195. Yamamoto M, Kiyono H. [Host defence mechanisms offered by the mucosal immune system]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:447-53. PMID: 15861694.
      View in: PubMed
    196. Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, Kiyono H. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J Immunol. 2005 Apr 01; 174(7):4365-72. PMID: 15778401.
      View in: PubMed
    197. Nochi T, Kiyono H. [Mucosal immunology]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:14-9. PMID: 15861629.
      View in: PubMed
    198. Kai Y, Takahashi I, Ishikawa H, Hiroi T, Mizushima T, Matsuda C, Kishi D, Hamada H, Tamagawa H, Ito T, Yoshizaki K, Kishimoto T, Matsuda H, Kiyono H. Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells. Gastroenterology. 2005 Apr; 128(4):922-34. PMID: 15825075.
      View in: PubMed
    199. Kobayashi R, Kohda T, Kataoka K, Ihara H, Kozaki S, Pascual DW, Staats HF, Kiyono H, McGhee JR, Fujihashi K. A novel neurotoxoid vaccine prevents mucosal botulism. J Immunol. 2005 Feb 15; 174(4):2190-5. PMID: 15699151.
      View in: PubMed
    200. Nonaka S, Naito T, Chen H, Yamamoto M, Moro K, Kiyono H, Hamada H, Ishikawa H. Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J Immunol. 2005 Feb 15; 174(4):1906-12. PMID: 15699117.
      View in: PubMed
    201. Nochi T, Yuki Y, Terahara K, Hino A, Kunisawa J, Kweon MN, Yamaguchi T, Kiyono H. Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium. Clin Immunol. 2004 Dec; 113(3):326-39. PMID: 15507398.
      View in: PubMed
    202. Yoshino N, Lü FX, Fujihashi K, Hagiwara Y, Kataoka K, Lu D, Hirst L, Honda M, van Ginkel FW, Takeda Y, Miller CJ, Kiyono H, McGhee JR. A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. J Immunol. 2004 Dec 01; 173(11):6850-7. PMID: 15557179.
      View in: PubMed
    203. Ohmura-Hoshino M, Yamamoto M, Yuki Y, Takeda Y, Kiyono H. Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity. Vaccine. 2004 Sep 09; 22(27-28):3751-61. PMID: 15315856.
      View in: PubMed
    204. Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol. 2004 Sep 01; 173(5):3337-47. PMID: 15322197.
      View in: PubMed
    205. Kiyono H, Fukuyama S. NALT- versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol. 2004 Sep; 4(9):699-710. PMID: 15343369.
      View in: PubMed
    206. Yamamoto M, Kweon MN, Rennert PD, Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity. J Immunol. 2004 Jul 15; 173(2):762-9. PMID: 15240662.
      View in: PubMed
    207. Shikina T, Hiroi T, Iwatani K, Jang MH, Fukuyama S, Tamura M, Kubo T, Ishikawa H, Kiyono H. IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J Immunol. 2004 May 15; 172(10):6259-64. PMID: 15128814.
      View in: PubMed
    208. Mizushima T, Ito T, Kishi D, Kai Y, Tamagawa H, Nezu R, Kiyono H, Matsuda H. Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. Inflamm Bowel Dis. 2004 May; 10(3):182-92. PMID: 15290910.
      View in: PubMed
    209. Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K, Sasakawa C, Suzuki T, Nochi T, Yokota Y, Rennert PD, Hiroi T, Tamagawa H, Iijima H, Kunisawa J, Yuki Y, Kiyono H. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6110-5. PMID: 15071180; PMCID: PMC395931.
    210. Hino A, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea. Am J Pathol. 2004 Apr; 164(4):1327-35. PMID: 15039220; PMCID: PMC1615363.
    211. Kiyono H. [Disease condition and the mechanism of the development of type 2 diabetes mellitus]. Nihon Naika Gakkai Zasshi. 2004 Feb 20; 93 Suppl:48-51. PMID: 15038121.
      View in: PubMed
    212. Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki J, Kiyono H. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. J Immunol. 2003 Oct 15; 171(8):4131-9. PMID: 14530335.
      View in: PubMed
    213. Yuki Y, Kiyono H. New generation of mucosal adjuvants for the induction of protective immunity. Rev Med Virol. 2003 Sep-Oct; 13(5):293-310. PMID: 12931340.
      View in: PubMed
    214. Tamagawa H, Takahashi I, Furuse M, Yoshitake-Kitano Y, Tsukita S, Ito T, Matsuda H, Kiyono H. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab Invest. 2003 Jul; 83(7):1045-53. PMID: 12861044.
      View in: PubMed
    215. Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K, Akira S. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest. 2003 May; 111(9):1297-308. PMID: 12727921; PMCID: PMC154445.
    216. Jang MH, Kweon MN, Hiroi T, Yamamoto M, Takahashi I, Kiyono H. Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells. Vaccine. 2003 Apr 02; 21(15):1613-9. PMID: 12639482.
      View in: PubMed
    217. Hagiwara Y, McGhee JR, Fujihashi K, Kobayashi R, Yoshino N, Kataoka K, Etani Y, Kweon MN, Tamura S, Kurata T, Takeda Y, Kiyono H, Fujihashi K. Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. J Immunol. 2003 Feb 15; 170(4):1754-62. PMID: 12574339.
      View in: PubMed
    218. Sakaue G, Hiroi T, Nakagawa Y, Someya K, Iwatani K, Sawa Y, Takahashi H, Honda M, Kunisawa J, Kiyono H. HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. J Immunol. 2003 Jan 01; 170(1):495-502. PMID: 12496436.
      View in: PubMed
    219. Boyaka PN, Ohmura M, Fujihashi K, Koga T, Yamamoto M, Kweon MN, Takeda Y, Jackson RJ, Kiyono H, Yuki Y, McGhee JR. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. J Immunol. 2003 Jan 01; 170(1):454-62. PMID: 12496431.
      View in: PubMed
    220. Okuda Y, Takahashi I, Kim JK, Ohta N, Iwatani K, Iijima H, Kai Y, Tamagawa H, Hiroi T, Kweon MN, Kawano S, Takeda K, Akira S, Sasaki Y, Hori M, Kiyono H. Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells. Am J Pathol. 2003 Jan; 162(1):263-71. PMID: 12507909; PMCID: PMC1851110.
    221. Kweon MN, Kiyono H. Eosinophilic gastroenteritis: a problem of the mucosal immune system? Curr Allergy Asthma Rep. 2003 Jan; 3(1):79-85. PMID: 12542999.
      View in: PubMed
    222. Kawahara M, Matsuo K, Nakasone T, Hiroi T, Kiyono H, Matsumoto S, Yamada T, Yamamoto N, Honda M. Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen. Vaccine. 2002 Dec 13; 21(3-4):158-66. PMID: 12450689.
      View in: PubMed
    223. Yuki Y, Kiyono H. [M cells: development and function]. Tanpakushitsu Kakusan Koso. 2002 Dec; 47(16 Suppl):2325-30. PMID: 12518456.
      View in: PubMed
    224. Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, Kiyono H. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. J Immunol. 2002 Dec 01; 169(11):6187-92. PMID: 12444123.
      View in: PubMed
    225. Watanabe I, Hagiwara Y, Kadowaki SE, Yoshikawa T, Komase K, Aizawa C, Kiyono H, Takeda Y, McGhee JR, Chiba J, Sata T, Kurata T, Tamura S. Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K). Vaccine. 2002 Oct 04; 20(29-30):3443-55. PMID: 12297389.
      View in: PubMed
    226. Kweon MN, Yamamoto M, Watanabe F, Tamura S, Van Ginkel FW, Miyauchi A, Takagi H, Takeda Y, Hamabata T, Fujihashi K, McGhee JR, Kiyono H. A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies. J Infect Dis. 2002 Nov 01; 186(9):1261-9. PMID: 12402195.
      View in: PubMed
    227. Yanagita M, Shimabukuro Y, Nozaki T, Yoshimura N, Watanabe J, Koide H, Terakura M, Saho T, Takedachi M, Jang MH, Kiyono H, Murakami S. IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):329-34. PMID: 12237122.
      View in: PubMed
    228. Kunisawa J, Takahashi I, Okudaira A, Hiroi T, Katayama K, Ariyama T, Tsutsumi Y, Nakagawa S, Kiyono H, Mayumi T. Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur J Immunol. 2002 Aug; 32(8):2347-55. PMID: 12209648.
      View in: PubMed
    229. Suenobu N, Kweon MN, Kiyono H. Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis. Vaccine. 2002 Jul 26; 20(23-24):2972-80. PMID: 12126910.
      View in: PubMed
    230. Enose Y, Ui M, Miyake A, Suzuki H, Uesaka H, Kuwata T, Kunisawa J, Kiyono H, Takahashi H, Miura T, Hayami M. Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV. Virology. 2002 Jul 05; 298(2):306-16. PMID: 12127792.
      View in: PubMed
    231. Fukuyama S, Hiroi T, Yokota Y, Rennert PD, Yanagita M, Kinoshita N, Terawaki S, Shikina T, Yamamoto M, Kurono Y, Kiyono H. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity. 2002 Jul; 17(1):31-40. PMID: 12150889.
      View in: PubMed
    232. Ohta N, Hiroi T, Kweon MN, Kinoshita N, Jang MH, Mashimo T, Miyazaki J, Kiyono H. IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation. J Immunol. 2002 Jul 01; 169(1):460-8. PMID: 12077277.
      View in: PubMed
    233. Takahashi I, Matsuda J, Gapin L, DeWinter H, Kai Y, Tamagawa H, Kronenberg M, Kiyono H. Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice. Clin Immunol. 2002 Mar; 102(3):237-48. PMID: 11890710.
      View in: PubMed
    234. Kweon MN, Kiyono H. CD40L in autoimmunity and mucosally induced tolerance. J Clin Invest. 2002 Jan; 109(2):171-3. PMID: 11805128; PMCID: PMC150848.
    235. Hamada H, Hiroi T, Nishiyama Y, Takahashi H, Masunaga Y, Hachimura S, Kaminogawa S, Takahashi-Iwanaga H, Iwanaga T, Kiyono H, Yamamoto H, Ishikawa H. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol. 2002 Jan 01; 168(1):57-64. PMID: 11751946.
      View in: PubMed
    Hiroshi's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _