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Hiroshi Kiyono

Title(s)Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0063
La Jolla CA 92093
Phone000-000-NULL
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcuspneumoniae-Specific IgA and Th17 Mediated Protective Immunity. Microorganisms. 2020 Jul 23; 8(8). Yoshii K, Hosomi K, Shimoyama A, Wang Y, Yamaura H, Nagatake T, Suzuki H, Lan H, Kiyono H, Fukase K, Kunisawa J. PMID: 32718009.
      View in: PubMed   Mentions:
    2. Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine. Vaccines (Basel). 2020 Jul 20; 8(3). Wang Y, Hosomi K, Shimoyama A, Yoshii K, Yamaura H, Nagatake T, Nishino T, Kiyono H, Fukase K, Kunisawa J. PMID: 32698404.
      View in: PubMed   Mentions:
    3. A Heterodimeric Antibody Fragment for Passive Immunotherapy Against Norovirus Infection. J Infect Dis. 2020 Jul 06; 222(3):470-478. Yuki Y, Kurokawa S, Sato S, Sasou A, Matsumoto N, Suzuki A, Sakon N, Goda Y, Takeyama N, Miyoshi T, Marcotte H, Tanaka T, Hammarstrom L, Kiyono H. PMID: 32211769.
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    4. Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts. Cell Host Microbe. 2020 Jul 03. Fujimoto K, Kimura Y, Shimohigoshi M, Satoh T, Sato S, Tremmel G, Uematsu M, Kawaguchi Y, Usui Y, Nakano Y, Hayashi T, Kashima K, Yuki Y, Yamaguchi K, Furukawa Y, Kakuta M, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. PMID: 32652061.
      View in: PubMed   Mentions:    Fields:    
    5. Fecal microbiome composition in healthy adults in Ghana. Jpn J Infect Dis. 2020 Jun 30. Parbie PK, Mizutani T, Ishizaka A, Kawana-Tachikawa A, Runtuwene LR, Seki S, Abana CZ, Kushitor D, Bonney EY, Ofori SB, Uematsu S, Imoto S, Kimura Y, Kiyono H, Ishikawa K, Ampofo WK, Matano T. PMID: 32611986.
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    6. Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon. Int Immunol. 2020 04 12; 32(4):243-258. Isobe J, Maeda S, Obata Y, Iizuka K, Nakamura Y, Fujimura Y, Kimizuka T, Hattori K, Kim YG, Morita T, Kimura I, Offermanns S, Adachi T, Nakao A, Kiyono H, Takahashi D, Hase K. PMID: 31858119.
      View in: PubMed   Mentions: 1     Fields:    
    7. Maternal ?3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy. 2020 Aug; 75(8):1935-1951. Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, Ono S, Shibuya N, Saito E, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Tomonaga T, Kiyono H, Kabashima K, Arita M, Kunisawa J. PMID: 32027039.
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    8. Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity. Mucosal Immunol. 2020 Jul; 13(4):679-690. Nakamura Y, Mimuro H, Kunisawa J, Furusawa Y, Takahashi D, Fujimura Y, Kaisho T, Kiyono H, Hase K. PMID: 32042052.
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    9. Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. Int Immunol. 2020 02 07; 32(2):133-141. Takahashi I, Hosomi K, Nagatake T, Toubou H, Yamamoto D, Hayashi I, Kurashima Y, Sato S, Shibata N, Goto Y, Maruyama F, Nakagawa I, Kuwae A, Abe A, Kunisawa J, Kiyono H. PMID: 31630178.
      View in: PubMed   Mentions: 1     Fields:    
    10. Essential Role of Host Double-Stranded DNA Released from Dying Cells by Cationic Liposomes for Mucosal Adjuvanticity. Vaccines (Basel). 2019 Dec 27; 8(1). Tada R, Ohshima A, Tanazawa Y, Ohmi A, Takahashi S, Kiyono H, Kunisawa J, Aramaki Y, Negishi Y. PMID: 31892192.
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    11. A role for the CCR5-CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization. Mucosal Immunol. 2019 11; 12(6):1391-1403. Joo S, Suwanto A, Sato A, Nakahashi-Ouchida R, Mori H, Uchida Y, Sato S, Kurashima Y, Yuki Y, Fujihashi K, Kawaguchi Y, Kiyono H. PMID: 31551493.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    12. Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. Immunity. 2019 09 17; 51(3):508-521.e6. Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M. PMID: 31471109.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases. Gastroenterology. 2019 12; 157(6):1530-1543.e4. Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S. PMID: 31445037.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    14. Distinct roles for Peyer's patch B cells for induction of antigen-specific IgA antibody responses in mice administered oral recombinant Salmonella. Int Immunol. 2019 07 30; 31(8):531-541. Hashizume-Takizawa T, Shibata N, Kurashima Y, Kiyono H, Kurita-Ochiai T, Fujihashi K. PMID: 30868152.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis. Sci Rep. 2019 07 25; 9(1):10842. Nishida K, Hasegawa A, Yamasaki S, Uchida R, Ohashi W, Kurashima Y, Kunisawa J, Kimura S, Iwanaga T, Watarai H, Hase K, Ogura H, Nakayama M, Kashiwakura JI, Okayama Y, Kubo M, Ohara O, Kiyono H, Koseki H, Murakami M, Hirano T. PMID: 31346193.
      View in: PubMed   Mentions: 2     Fields:    
    16. Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells. Front Immunol. 2019; 10:1281. Kurashima Y, Tokuhara D, Kamioka M, Inagaki Y, Kiyono H. PMID: 31275305.
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    17. Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases. Gut Microbes. 2020 05 03; 11(3):276-284. Hosomi K, Kiyono H, Kunisawa J. PMID: 31120334.
      View in: PubMed   Mentions: 1     Fields:    
    18. Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation. J Allergy Clin Immunol. 2019 09; 144(3):698-709.e9. Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H. PMID: 31125592.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice. Allergy. 2019 08; 74(8):1522-1532. Tiwari P, Nagatake T, Hirata SI, Sawane K, Saika A, Shibata Y, Morimoto S, Honda T, Adachi J, Abe Y, Isoyama J, Tomonaga T, Kiyono H, Kabashima K, Kunisawa J. PMID: 30843234.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. [MUCOSAL MULTI-ECOSYSTEM FOR THE PREVENTION AND TREATMENT OF MUCOSAL DISORDERS]. Arerugi. 2019; 68(6):675-680. Tokuhara D, Kiyono H. PMID: 31308333.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. New trends in mucosal immunology and allergy. Allergol Int. 2019 Jan; 68(1):1-3. Kiyono H, Izuhara K. PMID: 30591151.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    22. [THE MUCOSAL IMMUNE SYSTEM LEADS TO THE DEVELOPMENT OF NOVEL STRATEGY FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES]. Arerugi. 2019; 68(8):933-941. Yoshihara S, Kiyono H. PMID: 31534104.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Human Norovirus Propagation in Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells. Cell Mol Gastroenterol Hepatol. 2019; 7(3):686-688.e5. Sato S, Hisaie K, Kurokawa S, Suzuki A, Sakon N, Uchida Y, Yuki Y, Kiyono H. PMID: 30543870.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. A comprehensive understanding of the gut mucosal immune system in allergic inflammation. Allergol Int. 2019 Jan; 68(1):17-25. Tokuhara D, Kurashima Y, Kamioka M, Nakayama T, Ernst P, Kiyono H. PMID: 30366757.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    25. Polymeric Caffeic Acid Is a Safer Mucosal Adjuvant That Augments Antigen-Specific Mucosal and Systemic Immune Responses in Mice. Mol Pharm. 2018 09 04; 15(9):4226-4234. Tada R, Yamanaka D, Ogasawara M, Saito M, Ohno N, Kiyono H, Kunisawa J, Aramaki Y. PMID: 30107747.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    26. ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract. Int J Mol Sci. 2018 Aug 12; 19(8). Inami A, Kiyono H, Kurashima Y. PMID: 30103545.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases. Hum Vaccin Immunother. 2018; 14(9):2189-2193. Nakahashi-Ouchida R, Yuki Y, Kiyono H. PMID: 29624474.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Intranasal administration of cationic liposomes enhanced granulocyte-macrophage colony-stimulating factor expression and this expression is dispensable for mucosal adjuvant activity. BMC Res Notes. 2018 Jul 13; 11(1):472. Tada R, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y. PMID: 30005702.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    29. Nasal vaccination with pneumococcal surface protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice. Int Immunopharmacol. 2018 Aug; 61:385-393. Tada R, Suzuki H, Takahashi S, Negishi Y, Kiyono H, Kunisawa J, Aramaki Y. PMID: 29945026.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    30. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing. Int Immunol. 2018 04 03; 30(4):141-154. Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S. PMID: 29617862.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Characterization of morphological conversion of Helicobacter pylori under anaerobic conditions. Microbiol Immunol. 2018 Apr; 62(4):221-228. Hirukawa S, Sagara H, Kaneto S, Kondo T, Kiga K, Sanada T, Kiyono H, Mimuro H. PMID: 29446491.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    32. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Sci Transl Med. 2018 02 21; 10(429). Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S. PMID: 29467297.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    33. Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. Sci Rep. 2018 02 13; 8(1):2904. Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J. PMID: 29440671.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    34. Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity. Mucosal Immunol. 2018 05; 11(3):693-702. Shibata N, Kunisawa J, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K, Kiyono H. PMID: 29411777.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents. J Hypertens. 2018 02; 36(2):387-394. Azegami T, Yuki Y, Hayashi K, Hishikawa A, Sawada SI, Ishige K, Akiyoshi K, Kiyono H, Itoh H. PMID: 28832363.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    36. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2018 08; 142(2):470-484.e12. Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J. PMID: 29288079.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    37. Development of immune and microbial environments is independently regulated in the mammary gland. Mucosal Immunol. 2018 05; 11(3):643-653. Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H. PMID: 29346344.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    38. Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System. Front Immunol. 2017; 8:1787. Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H. PMID: 29321781.
      View in: PubMed   Mentions: 2     Fields:    
    39. A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. Stem Cell Reports. 2018 01 09; 10(1):314-328. Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H. PMID: 29233552.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. Dietary and Microbial Metabolites in the Regulation of Host Immunity. Front Microbiol. 2017; 8:2171. Shibata N, Kunisawa J, Kiyono H. PMID: 29163449.
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    41. Nanogel-based nasal vaccines for infectious and lifestyle-related diseases. Mol Immunol. 2018 06; 98:19-24. Azegami T, Yuki Y, Nakahashi R, Itoh H, Kiyono H. PMID: 29096936.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    42. Development of a nanogel-based nasal vaccine as a novel antigen delivery system. Expert Rev Vaccines. 2017 12; 16(12):1231-1240. Nakahashi-Ouchida R, Yuki Y, Kiyono H. PMID: 29053938.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    43. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. J Clin Invest. 2017 Oct 02; 127(10):3784-3795. Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y. PMID: 28891812.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    44. IL-22 induces Reg3? and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017 Oct 02; 214(10):3037-3050. Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. PMID: 28811323.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells. EBioMedicine. 2017 Sep; 23:34-45. Takahashi Y, Sato S, Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T, Kiyono H. PMID: 28789943.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    46. Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit. Sci Rep. 2017 07 12; 7(1):5196. Ogawa T, Kashima K, Yuki Y, Mejima M, Kurokawa S, Kuroda M, Okazawa A, Kiyono H, Ohta D. PMID: 28701756.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    47. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches. Sci Rep. 2017 06 21; 7(1):3980. Kim SH, Cho BH, Kiyono H, Jang YS. PMID: 28638068.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    48. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med. 2017 06 05; 214(6):1607-1618. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H. PMID: 28512157.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    49. Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Immunity. 2017 05 16; 46(5):863-874.e4. Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H. PMID: 28514691.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    50. MicroRNA-mediated dynamic control of mucosal immunity. Int Immunol. 2017 04 01; 29(4):157-163. Park EJ, Shimaoka M, Kiyono H. PMID: 28383678.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    51. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy. PLoS One. 2017; 12(2):e0172795. Nakajima-Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, Murakami H, Hosono A, Nochi T, Wakatsuki Y, Shimojo N, Kaminogawa S, Sato R, Kiyono H, Hachimura S. PMID: 28234975.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    52. Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nat Commun. 2017 02 22; 8:14509. Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H. PMID: 28224999.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One. 2017; 12(2):e0172509. Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K. PMID: 28225814.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    54. Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice. BMC Res Notes. 2017 Jan 26; 10(1):68. Tada R, Muto S, Iwata T, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y. PMID: 28126014.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    55. Nanogel-based nasal ghrelin vaccine prevents obesity. Mucosal Immunol. 2017 09; 10(5):1351-1360. Azegami T, Yuki Y, Sawada S, Mejima M, Ishige K, Akiyoshi K, Itoh H, Kiyono H. PMID: 28120848.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    56. Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. Annu Rev Immunol. 2017 04 26; 35:119-147. Kurashima Y, Kiyono H. PMID: 28125357.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    57. The spleen is the site where mast cells are induced in the development of food allergy. Int Immunol. 2017 01 01; 29(1):31-45. Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R. PMID: 28177443.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    58. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunol. 2017 07; 10(4):901-911. Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF, Kiyono H. PMID: 27924821.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    59. Epithelial extracellular ATP: an initiator of immunity to parasitic infections. Immunol Cell Biol. 2017 02; 95(2):117-118. Nelson S, Kiyono H, Kurashima Y. PMID: 27874014.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    60. Epithelial glycosylation in gut homeostasis and inflammation. Nat Immunol. 2016 Oct 19; 17(11):1244-1251. Goto Y, Uematsu S, Kiyono H. PMID: 27760104.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    61. MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation. BMB Rep. 2016 May; 49(5):263-9. Lee J, Park EJ, Kiyono H. PMID: 26923304.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    62. Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism. Immunity. 2016 Mar 15; 44(3):634-646. Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF. PMID: 26982365.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    63. [MAST CELL MEDIATED HOMEOSTATIC AND BARRIER SYSTEM]. Arerugi. 2016 Mar; 65(2):104-12. Kogure Y, Kurashima Y, Kiyono H. PMID: 27086955.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    64. Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. Regul Toxicol Pharmacol. 2016 Apr; 76:128-36. Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H. PMID: 26851506.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    65. Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy. Front Nutr. 2016; 3:3. Kunisawa J, Kiyono H. PMID: 26858949.
      View in: PubMed   Mentions:
    66. The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine. Vaccine. 2016 Feb 24; 34(9):1201-7. Saito S, Ainai A, Suzuki T, Harada N, Ami Y, Yuki Y, Takeyama H, Kiyono H, Tsukada H, Hasegawa H. PMID: 26802605.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    67. Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants. Plant Cell Rep. 2016 Mar; 35(3):667-79. Kashima K, Yuki Y, Mejima M, Kurokawa S, Suzuki Y, Minakawa S, Takeyama N, Fukuyama Y, Azegami T, Tanimoto T, Kuroda M, Tamura M, Gomi Y, Kiyono H. PMID: 26661780.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    68. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis. Sci Rep. 2015 Dec 09; 5:18174. Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H. PMID: 26647826.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    69. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages. PLoS One. 2015; 10(11):e0142920. Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H. PMID: 26575399.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    70. IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut. Sci Rep. 2015 Nov 02; 5:15918. Goto Y, Lamichhane A, Kamioka M, Sato S, Honda K, Kunisawa J, Kiyono H. PMID: 26522513.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    71. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice. PLoS One. 2015; 10(10):e0139785. Tada R, Hidaka A, Iwase N, Takahashi S, Yamakita Y, Iwata T, Muto S, Sato E, Takayama N, Honjo E, Kiyono H, Kunisawa J, Aramaki Y. PMID: 26440657.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    72. [Roles of the gut mucosal immune system in symbiosis and immunity]. Rinsho Ketsueki. 2015 Oct; 56(10):2205-12. Goto Y, Kurashima Y, Kiyono H. PMID: 26458461.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    73. Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice. PLoS One. 2015; 10(9):e0139368. Fukuyama Y, Okada K, Yamaguchi M, Kiyono H, Mori K, Yuki Y. PMID: 26422280.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    74. Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1. Cell Rep. 2015 Oct 06; 13(1):122-131. Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M, Kiyono H. PMID: 26411688.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    75. Plant-based vaccines for animals and humans: recent advances in technology and clinical trials. Ther Adv Vaccines. 2015 Sep; 3(5-6):139-54. Takeyama N, Kiyono H, Yuki Y. PMID: 26668752.
      View in: PubMed   Mentions:
    76. Oral rice-based vaccine induces passive and active immunity against enterotoxigenic E. coli-mediated diarrhea in pigs. Vaccine. 2015 Sep 22; 33(39):5204-11. Takeyama N, Yuki Y, Tokuhara D, Oroku K, Mejima M, Kurokawa S, Kuroda M, Kodama T, Nagai S, Ueda S, Kiyono H. PMID: 26254309.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    77. Structural basis of blocking integrin activation and deactivation for anti-inflammation. J Biomed Sci. 2015 Jul 08; 22:51. Park EJ, Yuki Y, Kiyono H, Shimaoka M. PMID: 26152212.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    78. The gut microbiota and inflammatory bowel disease. Curr Opin Rheumatol. 2015 Jul; 27(4):388-96. Goto Y, Kurashima Y, Kiyono H. PMID: 26002031.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    79. Dietary ?3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep. 2015 Jun 11; 5:9750. Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. PMID: 26065911.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    80. C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine. PLoS One. 2015; 10(5):e0126352. Suzuki H, Watari A, Hashimoto E, Yonemitsu M, Kiyono H, Yagi K, Kondoh M, Kunisawa J. PMID: 26018248.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    81. Central Role of Core Binding Factor ß2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. PLoS One. 2015; 10(5):e0127460. Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H. PMID: 26001080.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    82. Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation. Mediators Inflamm. 2015; 2015:427125. Kurashima Y, Kiyono H, Kunisawa J. PMID: 25944982.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    83. Negative regulation of DSS-induced experimental colitis by PILRa. Int Immunol. 2015 Jun; 27(6):307-14. Kishida K, Kohyama M, Kurashima Y, Kogure Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H. PMID: 25710489.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    84. The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015 Feb 17; 42(2):279-293. Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K. PMID: 25692702.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    85. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunol. 2015 Sep; 8(5):1144-53. Fukuyama Y, Yuki Y, Katakai Y, Harada N, Takahashi H, Takeda S, Mejima M, Joo S, Kurokawa S, Sawada S, Shibata H, Park EJ, Fujihashi K, Briles DE, Yasutomi Y, Tsukada H, Akiyoshi K, Kiyono H. PMID: 25669148.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    86. Comparative whole-genome analyses of selection marker-free rice-based cholera toxin B-subunit vaccine lines and wild-type lines. BMC Genomics. 2015 Feb 05; 16:48. Kashima K, Mejima M, Kurokawa S, Kuroda M, Kiyono H, Yuki Y. PMID: 25653106.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    87. Vitamins mediate immunological homeostasis and diseases at the surface of the body. Endocr Metab Immune Disord Drug Targets. 2015; 15(1):25-30. Kunisawa J, Kiyono H. PMID: 25335990.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    88. The mucosal immune system: From dentistry to vaccine development. Proc Jpn Acad Ser B Phys Biol Sci. 2015; 91(8):423-39. Kiyono H, Azegami T. PMID: 26460320.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    89. Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review. Gerontology. 2015; 61(4):336-42. Sato S, Kiyono H, Fujihashi K. PMID: 25531743.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    90. [Purinergic signaling mediates mast cell activation in intestinal inflammation]. Seikagaku. 2014 Dec; 86(6):798-802. Kurashima Y, Kiyono H, Kunisawa J. PMID: 25675821.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    91. Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease. J Immunol. 2015 Jan 01; 194(1):398-406. Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K. PMID: 25422510.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    92. Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy. PLoS One. 2014; 9(10):e107492. Nakajima-Adachi H, Kikuchi A, Fujimura Y, Shibahara K, Makino T, Goseki-Sone M, Kihara-Fujioka M, Nochi T, Kurashima Y, Igarashi O, Yamamoto M, Kunisawa J, Toda M, Kaminogawa S, Sato R, Kiyono H, Hachimura S. PMID: 25290461.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    93. Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. PLoS One. 2014; 9(9):e108294. Okura H, Sato S, Kishikawa S, Kaneto S, Nakashima T, Yoshida N, Takayanagi H, Kiyono H. PMID: 25244033.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    94. Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol. 2014 Dec; 88(23):13699-708. Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H. PMID: 25231301.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    95. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science. 2014 Sep 12; 345(6202):1254009. Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H. PMID: 25214634.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    96. Novel transgenic rice-based vaccines. Arch Immunol Ther Exp (Warsz). 2015 Apr; 63(2):87-99. Azegami T, Itoh H, Kiyono H, Yuki Y. PMID: 25027548.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsPHPublic Health
    97. Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. J Immunol. 2014 Aug 15; 193(4):1666-71. Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H. PMID: 25031459.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    98. Challenges in mucosal vaccines for the control of infectious diseases. Int Immunol. 2014 Sep; 26(9):517-28. Azegami T, Yuki Y, Kiyono H. PMID: 24914172.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    99. Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine. Dig Dis Sci. 2014 Nov; 59(11):2682-92. Tokuhara D, Nochi T, Matsumura A, Mejima M, Takahashi Y, Kurokawa S, Kiyono H, Yuki Y. PMID: 24838500.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    100. Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice. Inflamm Bowel Dis. 2014 May; 20(5):790-9. Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T. PMID: 24651581.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    101. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. Immunity. 2014 Apr 17; 40(4):530-41. Kurashima Y, Amiya T, Fujisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H. PMID: 24726878.
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    102. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 2014 Apr 10; 5:3704. Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. PMID: 24718324.
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    103. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 2014 Mar 18; 5:3492. Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. PMID: 24637670.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsPHPublic Health
    104. New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development. Exp Mol Med. 2014 Mar 14; 46:e83. Kurashima Y, Kiyono H. PMID: 24626169.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    105. Role of Lactobacillus pentosus Strain b240 and the Toll-like receptor 2 axis in Peyer's patch dendritic cell-mediated immunoglobulin A enhancement. PLoS One. 2014; 9(3):e91857. Kotani Y, Kunisawa J, Suzuki Y, Sato I, Saito T, Toba M, Kohda N, Kiyono H. PMID: 24632732.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    106. A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. J Biotechnol. 2014 Apr 10; 175:45-52. Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H. PMID: 24548461.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    107. Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. Exp Gerontol. 2014 Jun; 54:21-6. Fujihashi K, Sato S, Kiyono H. PMID: 24440991.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    108. [The development of mucosal vaccine using bacterial function for targeting mucosal tissues]. Yakugaku Zasshi. 2014; 134(5):629-34. Suzuki H, Kondoh M, Yagi K, Kiyono H, Kunisawa J. PMID: 24790045.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    109. Interleukin 15 and CD4? T cells cooperate to promote small intestinal enteropathy in response to dietary antigen. Gastroenterology. 2014 Apr; 146(4):1017-27. Korneychuk N, Ramiro-Puig E, Ettersperger J, Schulthess J, Montcuquet N, Kiyono H, Meresse B, Cerf-Bensussan N. PMID: 24361466.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    110. Nutritional components regulate the gut immune system and its association with intestinal immune disease development. J Gastroenterol Hepatol. 2013 Dec; 28 Suppl 4:18-24. Lamichhane A, Kiyono H, Kunisawa J. PMID: 24251698.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    111. Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur J Immunol. 2013 Dec; 43(12):3108-15. Kurashima Y, Goto Y, Kiyono H. PMID: 24414823.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    112. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17808-13. Kishino S, Takeuchi M, Park SB, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J. PMID: 24127592.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    113. RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds. Plant Cell Rep. 2014 Jan; 33(1):75-87. Kurokawa S, Kuroda M, Mejima M, Nakamura R, Takahashi Y, Sagara H, Takeyama N, Satoh S, Kiyono H, Teshima R, Masumura T, Yuki Y. PMID: 24085308.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    114. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. PLoS One. 2013; 8(8):e72050. Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y. PMID: 23951282.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    115. Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest. 2013 Sep; 123(9):3829-38. Tokuhara D, Álvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, Kuroda M, Oyama M, Kozuka-Hata H, Nochi T, Sagara H, Aladin F, Marcotte H, Frenken LG, Iturriza-Gómara M, Kiyono H, Hammarström L, Yuki Y. PMID: 23925294.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    116. Vitamin-mediated regulation of intestinal immunity. Front Immunol. 2013; 4:189. Kunisawa J, Kiyono H. PMID: 23874335.
      View in: PubMed   Mentions: 9     Fields:    
    117. MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of a-amylase/trypsin inhibitor-like protein family as major rice allergens. J Proteome Res. 2013 Jul 05; 12(7):3372-82. Kurokawa S, Nakamura R, Mejima M, Kozuka-Hata H, Kuroda M, Takeyama N, Oyama M, Satoh S, Kiyono H, Masumura T, Teshima R, Yuki Y. PMID: 23763241.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    118. Critical role of dendritic cells in T cell retention in the interfollicular region of Peyer's patches. J Immunol. 2013 Jul 15; 191(2):942-8. Obata T, Shibata N, Goto Y, Ishikawa I, Sato S, Kunisawa J, Kiyono H. PMID: 23772027.
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    119. Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol J. 2013 Sep; 11(7):799-808. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Takahashi Y, Tokuhara D, Nochi T, Katakai Y, Kuroda M, Takeyama N, Kashima K, Abe M, Chen Y, Nakanishi U, Masumura T, Takeuchi Y, Kozuka-Hata H, Shibata H, Oyama M, Tanaka K, Kiyono H. PMID: 23601492.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsPHPublic Health
    120. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One. 2013; 8(4):e60453. Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert RS, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee JR, Fujihashi K. PMID: 23565250.
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    121. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun. 2013 May; 81(5):1625-34. Kong IG, Sato A, Yuki Y, Nochi T, Takahashi H, Sawada S, Mejima M, Kurokawa S, Okada K, Sato S, Briles DE, Kunisawa J, Inoue Y, Yamamoto M, Akiyoshi K, Kiyono H. PMID: 23460513.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    122. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun. 2013; 4:1772. Kunisawa J, Gohda M, Hashimoto E, Ishikawa I, Higuchi M, Suzuki Y, Goto Y, Panea C, Ivanov II, Sumiya R, Aayam L, Wake T, Tajiri S, Kurashima Y, Shikata S, Akira S, Takeda K, Kiyono H. PMID: 23612313.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCellsPHPublic Health
    123. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun. 2013; 4:1949. Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K. PMID: 23752491.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    124. Nanogel-based antigen-delivery system for nasal vaccines. Biotechnol Genet Eng Rev. 2013; 29:61-72. Yuki Y, Nochi T, Kong IG, Takahashi H, Sawada S, Akiyoshi K, Kiyono H. PMID: 24568253.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    125. Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol. 2013 Jan 15; 190(2):774-83. Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K. PMID: 23241884.
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    126. Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells. Mucosal Immunol. 2013 Jul; 6(4):838-46. Sato S, Kaneto S, Shibata N, Takahashi Y, Okura H, Yuki Y, Kunisawa J, Kiyono H. PMID: 23212199.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    127. Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4?T cells into the Th2 or Th1 phenotype. Biosci Biotechnol Biochem. 2012; 76(10):1979-81. Nakajima-Adachi H, Koike E, Totsuka M, Hiraide E, Wakatsuki Y, Kiyono H, Hachimura S. PMID: 23047087.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    128. Summary for symposium I on the development of a more efficacious influenza vaccine held at the 15th Annual Meeting of the Japanese Society for Vaccinology, Tokyo, 2011. Vaccine. 2012 Sep 28; 30(44):6338-9. Kumagai T, Kiyono H. PMID: 22906723.
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    129. Immune regulation and monitoring at the epithelial surface of the intestine. Drug Discov Today. 2013 Jan; 18(1-2):87-92. Kunisawa J, Kiyono H. PMID: 22897879.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    130. Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol. 2012 Sep 15; 189(6):2869-78. Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K. PMID: 22869901.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    131. PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 2012 Oct; 24(10):613-23. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K. PMID: 22836022.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    132. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 2012 Jun 08; 336(6086):1321-5. Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D. PMID: 22674331.
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    133. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog. 2012; 8(5):e1002714. Jeon SG, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, Tsuji NM, Kiyono H, Ma JS, Kusu T, Okumura R, Hara H, Yoshida H, Yamamoto M, Nomoto K, Takeda K. PMID: 22693446.
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    134. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice. J Immunol. 2012 Jun 15; 188(12):6145-55. Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F. PMID: 22611244.
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    135. RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine. Vaccine. 2012 Jun 13; 30(28):4160-6. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Kong IG, Kuroda M, Takahashi Y, Nochi T, Tokuhara D, Kohda T, Kozaki S, Kiyono H. PMID: 22554467.
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    136. The mucosal immune system of the respiratory tract. Curr Opin Virol. 2012 Jun; 2(3):225-32. Sato S, Kiyono H. PMID: 22542216.
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    137. Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses. Front Immunol. 2012; 3:65. Kunisawa J, Kiyono H. PMID: 22566946.
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    138. Immunological function of sphingosine 1-phosphate in the intestine. Nutrients. 2012 03; 4(3):154-66. Kunisawa J, Kiyono H. PMID: 22666543.
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    139. Novel vaccine development strategies for inducing mucosal immunity. Expert Rev Vaccines. 2012 Mar; 11(3):367-79. Fujkuyama Y, Tokuhara D, Kataoka K, Gilbert RS, McGhee JR, Yuki Y, Kiyono H, Fujihashi K. PMID: 22380827.
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    140. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 2012; 7(2):e32094. Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H. PMID: 22363800.
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    141. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood. 2012 Mar 22; 119(12):2768-77. Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F. PMID: 22279057.
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    142. Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model. Allergy. 2012 Apr; 67(4):502-9. Kim DY, Fukuyama S, Nagatake T, Takamura K, Kong IG, Yokota Y, Lee CH, Kiyono H. PMID: 22257110.
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    143. Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol Rev. 2012 Jan; 245(1):147-63. Goto Y, Kiyono H. PMID: 22168418.
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    144. M cell-targeted mucosal vaccine strategies. Curr Top Microbiol Immunol. 2012; 354:39-52. Yamamoto M, Pascual DW, Kiyono H. PMID: 21688209.
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    145. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun. 2012; 3:1034. Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H. PMID: 22948816.
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    146. [Mucosal immune systems--frontline of the biological defence mechanism]. Nihon Jibiinkoka Gakkai Kaiho. 2011 Nov; 114(11):843-50. Kiyono H, Okada K. PMID: 22295432.
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    147. M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery. Eur J Immunol. 2011 Nov; 41(11):3219-29. Kim SH, Jung DI, Yang IY, Kim J, Lee KY, Nochi T, Kiyono H, Jang YS. PMID: 21887786.
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    148. [Current progress in the development of mucosal vaccines]. Nihon Rinsho. 2011 Sep; 69(9):1555-60. Takeyama N, Yuki Y, Kiyono H. PMID: 21922752.
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    149. Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine. Adv Otorhinolaryngol. 2011; 72:31-6. Okada K, Yamasoba T, Kiyono H. PMID: 21865684.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    150. Host pathogens. Editorial overview. Curr Opin Immunol. 2011 Aug; 23(4):445-7. Stappenbeck T, Kiyono H. PMID: 21856138.
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    151. Gut-associated lymphoid tissues for the development of oral vaccines. Adv Drug Deliv Rev. 2012 May 01; 64(6):523-30. Kunisawa J, Kurashima Y, Kiyono H. PMID: 21827802.
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    152. Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy. Mol Nutr Food Res. 2011 Oct; 55(10):1475-83. Burggraf M, Nakajima-Adachi H, Hachimura S, Ilchmann A, Pemberton AD, Kiyono H, Vieths S, Toda M. PMID: 21714123.
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    153. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011 May 19; 9(5):376-89. Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. PMID: 21575909.
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    154. Epithelial cell microRNAs in gut immunity. Nat Immunol. 2011 Mar; 12(3):195-7. Goto Y, Kiyono H. PMID: 21321589.
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    155. The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J Immunol. 2011 Apr 01; 186(7):4253-62. Kim DY, Sato A, Fukuyama S, Sagara H, Nagatake T, Kong IG, Goda K, Nochi T, Kunisawa J, Sato S, Yokota Y, Lee CH, Kiyono H. PMID: 21357262.
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    156. Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. Cell Host Microbe. 2011 Feb 17; 9(2):83-4. Kunisawa J, Kiyono H. PMID: 21320688.
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    157. Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun. 2011 Jan 21; 404(3):822-8. Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H. PMID: 21172308.
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    158. Mucosal regulatory cells in the gastrointestinal tract and periodontium. Periodontol 2000. 2010 Oct; 54(1):247-56. Takahashi I, Fujihashi K, Kiyono H. PMID: 20712644.
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    159. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010 Dec; 84(24):12703-12. Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S. PMID: 20881038.
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    160. In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates. J Immunol. 2010 Nov 01; 185(9):5436-43. Yuki Y, Nochi T, Harada N, Katakai Y, Shibata H, Mejima M, Kohda T, Tokuhara D, Kurokawa S, Takahashi Y, Ono F, Kozaki S, Terao K, Tsukada H, Kiyono H. PMID: 20881188.
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    161. High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. J Biol Chem. 2010 Oct 01; 285(40):30427-35. Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K. PMID: 20663890.
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    162. Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater. 2010 Jul; 9(7):572-8. Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H. PMID: 20562880.
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    163. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest. 2010 Jun; 120(6):2131-43. Malamut G, El Machhour R, Montcuquet N, Martin-Lannerée S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B. PMID: 20440074.
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    164. Aberrant interaction of the gut immune system with environmental factors in the development of food allergies. Curr Allergy Asthma Rep. 2010 May; 10(3):215-21. Kunisawa J, Kiyono H. PMID: 20424996.
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    165. Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8794-9. Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H. PMID: 20421480.
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    166. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7419-24. Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H. PMID: 20360558.
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    167. Antigen-sampling cells in the salmonid intestinal epithelium. Dev Comp Immunol. 2010 Jul; 34(7):768-74. Fuglem B, Jirillo E, Bjerkås I, Kiyono H, Nochi T, Yuki Y, Raida M, Fischer U, Koppang EO. PMID: 20178814.
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    168. Role of interleukin-15 in the development of mouse olfactory nerve. Congenit Anom (Kyoto). 2009 Dec; 49(4):253-7. Umehara T, Udagawa J, Takamura K, Kimura M, Ishimitsu R, Kiyono H, Kawauchi H, Otani H. PMID: 20021484.
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    169. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 2009 Nov 12; 462(7270):226-30. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H. PMID: 19907495.
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    170. [The mucosal immune system: new strategy for the control of allergic diseases]. Nihon Rinsho. 2009 Nov; 67(11):2194-9. Sato A, Kiyono H. PMID: 19899540.
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    171. A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity. J Immunol. 2009 Nov 15; 183(10):6538-44. Nochi T, Yuki Y, Katakai Y, Shibata H, Tokuhara D, Mejima M, Kurokawa S, Takahashi Y, Nakanishi U, Ono F, Mimuro H, Sasakawa C, Takaiwa F, Terao K, Kiyono H. PMID: 19880451.
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    172. RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J Immunol. 2009 Nov 01; 183(9):5738-47. Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR. PMID: 19828638.
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    173. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 2009 Oct 26; 206(11):2351-64. Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H. PMID: 19822644.
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    174. Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine. Histochem Cell Biol. 2009 Dec; 132(6):577-84. Suzuki R, Nourani MR, Saino-Saito S, Abe H, Nochi T, Kiyono H, Spener F, Kondo H, Owada Y. PMID: 19787366.
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    175. The effect of liposome-coated recombinant protein VP28 against white spot syndrome virus in kuruma shrimp, Marsupenaeus japonicus. J Fish Dis. 2010 Jan; 33(1):69-74. Mavichak R, Takano T, Kondo H, Hirono I, Wada S, Hatai K, Inagawa H, Takahashi Y, Yoshimura T, Kiyono H, Yuki Y, Aoki T. PMID: 19735346.
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    176. Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine. 2009 Oct 09; 27(43):5982-8. Yuki Y, Tokuhara D, Nochi T, Yasuda H, Mejima M, Kurokawa S, Takahashi Y, Kataoka N, Nakanishi U, Hagiwara Y, Fujihashi K, Takaiwa F, Kiyono H. PMID: 19665603.
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    177. Mucosal vaccines: novel advances in technology and delivery. Expert Rev Vaccines. 2009 Aug; 8(8):1083-97. Yuki Y, Kiyono H. PMID: 19627189.
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    178. Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends Immunol. 2009 Jul; 30(7):334-43. Fujihashi K, Kiyono H. PMID: 19540811.
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    179. New horizon of mucosal immunity and vaccines. Curr Opin Immunol. 2009 Jun; 21(3):352-8. Takahashi I, Nochi T, Yuki Y, Kiyono H. PMID: 19493665.
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    180. [Recent progress for the development of mucosal vaccine]. Tanpakushitsu Kakusan Koso. 2009 Jun; 54(8 Suppl):1089-95. Nochi T, Kiyono H. PMID: 21089546.
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    181. Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta. Int Arch Allergy Immunol. 2009; 150(2):164-71. Kim D, Kim SH, Park EJ, Kim J, Cho SH, Kagawa J, Arai N, Jun K, Kiyono H, Kim S. PMID: 19439982.
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    182. Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun. 2009 Jun 05; 383(3):340-6. Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. PMID: 19358828.
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    183. Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol. 2008 Nov; 29(11):505-13. Kunisawa J, Nochi T, Kiyono H. PMID: 18835748.
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    184. Oral immunization: an update. Curr Opin Gastroenterol. 2008 Nov; 24(6):713-9. Mestecky J, Nguyen H, Czerkinsky C, Kiyono H. PMID: 19122521.
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    185. The mucosa: at the frontlines of immunity. Trends Immunol. 2008 Nov; 29(11):503-4. Fehervari Z, Kiyono H. PMID: 18838300.
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    186. [MucoRice: development of rice-based oral vaccine]. Nihon Rinsho Meneki Gakkai Kaishi. 2008 Oct; 31(5):369-74. Yuki Y, Kiyono H. PMID: 18974620.
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    187. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 2008 Jun 15; 180(12):7840-6. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. PMID: 18523247.
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    188. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 2008 Jul; 9(7):769-76. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. PMID: 18516037.
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    189. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice. Int Immunol. 2008 Jul; 20(7):881-91. Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K. PMID: 18492657.
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    190. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol. 2008; 32(10):1211-20. Ooi EL, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. PMID: 18466972.
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    191. Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis. Fish Shellfish Immunol. 2008 Sep; 25(3):315-20. Caipang CM, Verjan N, Ooi EL, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. PMID: 18603448.
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    192. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2008 Jul; 25(1-2):170-80. Verjan N, Ooi EL, Nochi T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. PMID: 18499475.
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    193. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol. 2008 Apr 15; 180(8):5335-43. Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H. PMID: 18390715.
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    194. Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies. Infect Immun. 2008 Jun; 76(6):2777-84. Momoi F, Hashizume T, Kurita-Ochiai T, Yuki Y, Kiyono H, Yamamoto M. PMID: 18411288.
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    195. Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. J Immunol. 2008 Apr 01; 180(7):4361-5. Chang SY, Cha HR, Igarashi O, Rennert PD, Kissenpfennig A, Malissen B, Nanno M, Kiyono H, Kweon MN. PMID: 18354155.
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    196. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. Blood. 2008 May 01; 111(9):4646-52. Kunisawa J, Gohda M, Kurashima Y, Ishikawa I, Higuchi M, Kiyono H. PMID: 18292290.
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    197. [Applicable strategies for the mucosal immune system in the regulation of allergic diseases]. Arerugi. 2008 Feb; 57(2):87-94. Kurashima Y, Kunisawa J, Kiyono H. PMID: 18349582.
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    198. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol. 2008 Feb 01; 180(3):1609-18. Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN. PMID: 18209057.
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    199. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol. 2008 Jan; 1(1):31-7. Brandtzaeg P, Kiyono H, Pabst R, Russell MW. PMID: 19079158.
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    200. Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp. Infect Immun. 2008 Mar; 76(3):927-34. Hashizume T, Togawa A, Nochi T, Igarashi O, Kweon MN, Kiyono H, Yamamoto M. PMID: 18086815.
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    201. A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med. 2007 Nov 26; 204(12):2789-96. Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, Kim DY, Fukuyama S, Iwatsuki-Horimoto K, Kawaoka Y, Kohda T, Kozaki S, Igarashi O, Kiyono H. PMID: 17984304.
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    202. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 2007 Nov 01; 179(9):5897-906. Takamura K, Fukuyama S, Nagatake T, Kim DY, Kawamura A, Kawauchi H, Kiyono H. PMID: 17947663.
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    203. Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli. Fish Shellfish Immunol. 2008 May; 24(5):506-13. Ooi EL, Verjan N, Hirono I, Nochi T, Kondo H, Aoki T, Kiyono H, Yuki Y. PMID: 18329900.
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    204. Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med. 2007 Oct 01; 204(10):2335-48. Kunisawa J, Kurashima Y, Higuchi M, Gohda M, Ishikawa I, Ogahara I, Kim N, Shimizu M, Kiyono H. PMID: 17875673.
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    205. Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. J Immunol. 2007 Aug 01; 179(3):1577-85. Kurashima Y, Kunisawa J, Higuchi M, Gohda M, Ishikawa I, Takayama N, Shimizu M, Kiyono H. PMID: 17641024.
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    206. Progress towards an AIDS mucosal vaccine: an overview. Tuberculosis (Edinb). 2007 Aug; 87 Suppl 1:S35-44. Yuki Y, Nochi T, Kiyono H. PMID: 17652028.
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    207. Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10986-91. Nochi T, Takagi H, Yuki Y, Yang L, Masumura T, Mejima M, Nakanishi U, Matsumura A, Uozumi A, Hiroi T, Morita S, Tanaka K, Takaiwa F, Kiyono H. PMID: 17573530.
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    208. Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. J Virol. 2007 Aug; 81(15):7902-12. Ohka S, Igarashi H, Nagata N, Sakai M, Koike S, Nochi T, Kiyono H, Nomoto A. PMID: 17507470.
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    209. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8971-6. Nagai S, Mimuro H, Yamada T, Baba Y, Moro K, Nochi T, Kiyono H, Suzuki T, Sasakawa C, Koyasu S. PMID: 17502608.
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    210. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis. Inflamm Bowel Dis. 2007 May; 13(5):547-56. Tamagawa H, Hiroi T, Mizushima T, Ito T, Matsuda H, Kiyono H. PMID: 17245768.
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    211. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007 Apr 15; 178(8):4937-46. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M. PMID: 17404275.
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    212. Neuroregulator RET initiates Peyer's-patch tissue genesis. Immunity. 2007 Apr; 26(4):393-5. Fukuyama S, Kiyono H. PMID: 17459808.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    213. Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea. Clin Immunol. 2007 May; 123(2):199-208. Takayama N, Igarashi O, Kweon MN, Kiyono H. PMID: 17360239.
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    214. Gut lymphocyte migration: we are halfway 'home'. Trends Immunol. 2007 Apr; 28(4):150-3. McGhee JR, Kunisawa J, Kiyono H. PMID: 17293162.
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    215. [Uniqueness of the mucosal immune system for the development of prospective mucosal vaccine]. Yakugaku Zasshi. 2007 Feb; 127(2):319-26. Kunisawa J, Gohda M, Kiyono H. PMID: 17268152.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    216. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev. 2007 Feb; 215:136-53. Kunisawa J, Takahashi I, Kiyono H. PMID: 17291285.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    217. Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. Blood. 2007 May 01; 109(9):3749-56. Kunisawa J, Kurashima Y, Gohda M, Higuchi M, Ishikawa I, Miura F, Ogahara I, Kiyono H. PMID: 17234743.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCellsPHPublic Health
    218. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin Immunol. 2007 Apr; 123(1):30-9. Kim N, Kunisawa J, Kweon MN, Eog Ji G, Kiyono H. PMID: 17218154.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    219. Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine. 2007 Mar 30; 25(14):2680-7. Tanaka N, Fukuyama S, Fukuiwa T, Kawabata M, Sagara Y, Ito HO, Miwa Y, Nagatake T, Kiyono H, Kurono Y. PMID: 17270319.
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    220. Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. J Immunol. 2006 Oct 15; 177(8):5524-32. Maddaloni M, Staats HF, Mierzejewska D, Hoyt T, Robinson A, Callis G, Kozaki S, Kiyono H, McGhee JR, Fujihashi K, Pascual DW. PMID: 17015739.
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    221. Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J Immunol. 2006 Oct 01; 177(7):4276-80. Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H. PMID: 16982861.
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    222. A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking. J Immunol. 2006 Sep 01; 177(5):3045-54. Hagiwara Y, Kawamura YI, Kataoka K, Rahima B, Jackson RJ, Komase K, Dohi T, Boyaka PN, Takeda Y, Kiyono H, McGhee JR, Fujihashi K. PMID: 16920941.
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    223. Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J Immunol. 2006 Feb 01; 176(3):1776-83. Duverger A, Jackson RJ, van Ginkel FW, Fischer R, Tafaro A, Leppla SH, Fujihashi K, Kiyono H, McGhee JR, Boyaka PN. PMID: 16424208.
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    224. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol. 2006 Jan 15; 176(2):803-10. Jang MH, Sougawa N, Tanaka T, Hirata T, Hiroi T, Tohya K, Guo Z, Umemoto E, Ebisuno Y, Yang BG, Seoh JY, Lipp M, Kiyono H, Miyasaka M. PMID: 16393963.
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    225. Innate immunity in the mucosal immune system. Curr Pharm Des. 2006; 12(32):4203-13. Nochi T, Kiyono H. PMID: 17100623.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    226. Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes. Biotechnol Bioeng. 2005 Dec 30; 92(7):803-9. Yuki Y, Hara-Yakoyama C, Guadiz AA, Udaka S, Kiyono H, Chatterjee S. PMID: 16142801.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    227. A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17525-30. Takagi H, Hiroi T, Yang L, Tada Y, Yuki Y, Takamura K, Ishimitsu R, Kawauchi H, Kiyono H, Takaiwa F. PMID: 16278301.
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    228. Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Curr Mol Med. 2005 Sep; 5(6):557-72. Kunisawa J, Fukuyama S, Kiyono H. PMID: 16178767.
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    229. Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation. Infect Immun. 2005 Jul; 73(7):4088-97. Ohmura M, Yamamoto M, Tomiyama-Miyaji C, Yuki Y, Takeda Y, Kiyono H. PMID: 15972497.
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    230. A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. Cell Mol Life Sci. 2005 Jun; 62(12):1308-21. Kunisawa J, Kiyono H. PMID: 15971106.
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    231. Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea. J Immunol. 2005 Jun 01; 174(11):7423-32. Hino A, Fukuyama S, Kataoka K, Kweon MN, Fujihashi K, Kiyono H. PMID: 15905591.
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    232. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005 May 27; 331(1):285-94. Ueta M, Hamuro J, Kiyono H, Kinoshita S. PMID: 15845391.
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    233. [Mucosal immunology]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:14-9. Nochi T, Kiyono H. PMID: 15861629.
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    234. [Host defence mechanisms offered by the mucosal immune system]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:447-53. Yamamoto M, Kiyono H. PMID: 15861694.
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    235. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J Immunol. 2005 Apr 01; 174(7):4365-72. Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, Kiyono H. PMID: 15778401.
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    236. Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells. Gastroenterology. 2005 Apr; 128(4):922-34. Kai Y, Takahashi I, Ishikawa H, Hiroi T, Mizushima T, Matsuda C, Kishi D, Hamada H, Tamagawa H, Ito T, Yoshizaki K, Kishimoto T, Matsuda H, Kiyono H. PMID: 15825075.
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    237. A novel neurotoxoid vaccine prevents mucosal botulism. J Immunol. 2005 Feb 15; 174(4):2190-5. Kobayashi R, Kohda T, Kataoka K, Ihara H, Kozaki S, Pascual DW, Staats HF, Kiyono H, McGhee JR, Fujihashi K. PMID: 15699151.
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    238. Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J Immunol. 2005 Feb 15; 174(4):1906-12. Nonaka S, Naito T, Chen H, Yamamoto M, Moro K, Kiyono H, Hamada H, Ishikawa H. PMID: 15699117.
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    239. Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium. Clin Immunol. 2004 Dec; 113(3):326-39. Nochi T, Yuki Y, Terahara K, Hino A, Kunisawa J, Kweon MN, Yamaguchi T, Kiyono H. PMID: 15507398.
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    240. A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. J Immunol. 2004 Dec 01; 173(11):6850-7. Yoshino N, Lü FX, Fujihashi K, Hagiwara Y, Kataoka K, Lu D, Hirst L, Honda M, van Ginkel FW, Takeda Y, Miller CJ, Kiyono H, McGhee JR. PMID: 15557179.
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    241. Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity. Vaccine. 2004 Sep 09; 22(27-28):3751-61. Ohmura-Hoshino M, Yamamoto M, Yuki Y, Takeda Y, Kiyono H. PMID: 15315856.
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    242. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol. 2004 Sep 01; 173(5):3337-47. Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H. PMID: 15322197.
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    243. NALT- versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol. 2004 Sep; 4(9):699-710. Kiyono H, Fukuyama S. PMID: 15343369.
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    244. Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity. J Immunol. 2004 Jul 15; 173(2):762-9. Yamamoto M, Kweon MN, Rennert PD, Hiroi T, Fujihashi K, McGhee JR, Kiyono H. PMID: 15240662.
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    245. IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J Immunol. 2004 May 15; 172(10):6259-64. Shikina T, Hiroi T, Iwatani K, Jang MH, Fukuyama S, Tamura M, Kubo T, Ishikawa H, Kiyono H. PMID: 15128814.
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    246. Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. Inflamm Bowel Dis. 2004 May; 10(3):182-92. Mizushima T, Ito T, Kishi D, Kai Y, Tamagawa H, Nezu R, Kiyono H, Matsuda H. PMID: 15290910.
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    247. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6110-5. Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K, Sasakawa C, Suzuki T, Nochi T, Yokota Y, Rennert PD, Hiroi T, Tamagawa H, Iijima H, Kunisawa J, Yuki Y, Kiyono H. PMID: 15071180.
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    248. Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea. Am J Pathol. 2004 Apr; 164(4):1327-35. Hino A, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. PMID: 15039220.
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    249. [Disease condition and the mechanism of the development of type 2 diabetes mellitus]. Nihon Naika Gakkai Zasshi. 2004 Feb 20; 93 Suppl:48-51. Kiyono H. PMID: 15038121.
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    250. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. J Immunol. 2003 Oct 15; 171(8):4131-9. Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki J, Kiyono H. PMID: 14530335.
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    251. New generation of mucosal adjuvants for the induction of protective immunity. Rev Med Virol. 2003 Sep-Oct; 13(5):293-310. Yuki Y, Kiyono H. PMID: 12931340.
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    252. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab Invest. 2003 Jul; 83(7):1045-53. Tamagawa H, Takahashi I, Furuse M, Yoshitake-Kitano Y, Tsukita S, Ito T, Matsuda H, Kiyono H. PMID: 12861044.
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    253. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest. 2003 May; 111(9):1297-308. Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K, Akira S. PMID: 12727921.
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    254. Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells. Vaccine. 2003 Apr 02; 21(15):1613-9. Jang MH, Kweon MN, Hiroi T, Yamamoto M, Takahashi I, Kiyono H. PMID: 12639482.
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    255. Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. J Immunol. 2003 Feb 15; 170(4):1754-62. Hagiwara Y, McGhee JR, Fujihashi K, Kobayashi R, Yoshino N, Kataoka K, Etani Y, Kweon MN, Tamura S, Kurata T, Takeda Y, Kiyono H, Fujihashi K. PMID: 12574339.
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    256. HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. J Immunol. 2003 Jan 01; 170(1):495-502. Sakaue G, Hiroi T, Nakagawa Y, Someya K, Iwatani K, Sawa Y, Takahashi H, Honda M, Kunisawa J, Kiyono H. PMID: 12496436.
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    257. Eosinophilic gastroenteritis: a problem of the mucosal immune system? Curr Allergy Asthma Rep. 2003 Jan; 3(1):79-85. Kweon MN, Kiyono H. PMID: 12542999.
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    258. Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells. Am J Pathol. 2003 Jan; 162(1):263-71. Okuda Y, Takahashi I, Kim JK, Ohta N, Iwatani K, Iijima H, Kai Y, Tamagawa H, Hiroi T, Kweon MN, Kawano S, Takeda K, Akira S, Sasaki Y, Hori M, Kiyono H. PMID: 12507909.
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    259. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. J Immunol. 2003 Jan 01; 170(1):454-62. Boyaka PN, Ohmura M, Fujihashi K, Koga T, Yamamoto M, Kweon MN, Takeda Y, Jackson RJ, Kiyono H, Yuki Y, McGhee JR. PMID: 12496431.
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    260. Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen. Vaccine. 2002 Dec 13; 21(3-4):158-66. Kawahara M, Matsuo K, Nakasone T, Hiroi T, Kiyono H, Matsumoto S, Yamada T, Yamamoto N, Honda M. PMID: 12450689.
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    261. [M cells: development and function]. Tanpakushitsu Kakusan Koso. 2002 Dec; 47(16 Suppl):2325-30. Yuki Y, Kiyono H. PMID: 12518456.
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    262. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. J Immunol. 2002 Dec 01; 169(11):6187-92. Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, Kiyono H. PMID: 12444123.
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    263. Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K). Vaccine. 2002 Oct 04; 20(29-30):3443-55. Watanabe I, Hagiwara Y, Kadowaki SE, Yoshikawa T, Komase K, Aizawa C, Kiyono H, Takeda Y, McGhee JR, Chiba J, Sata T, Kurata T, Tamura S. PMID: 12297389.
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    264. A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies. J Infect Dis. 2002 Nov 01; 186(9):1261-9. Kweon MN, Yamamoto M, Watanabe F, Tamura S, Van Ginkel FW, Miyauchi A, Takagi H, Takeda Y, Hamabata T, Fujihashi K, McGhee JR, Kiyono H. PMID: 12402195.
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    265. IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):329-34. Yanagita M, Shimabukuro Y, Nozaki T, Yoshimura N, Watanabe J, Koide H, Terakura M, Saho T, Takedachi M, Jang MH, Kiyono H, Murakami S. PMID: 12237122.
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    266. Immunosuppressive properties of human amniotic membrane for mixed lymphocyte reaction. Clin Exp Immunol. 2002 Sep; 129(3):464-70. Ueta M, Kweon MN, Sano Y, Sotozono C, Yamada J, Koizumi N, Kiyono H, Kinoshita S. PMID: 12197887.
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    267. Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur J Immunol. 2002 Aug; 32(8):2347-55. Kunisawa J, Takahashi I, Okudaira A, Hiroi T, Katayama K, Ariyama T, Tsutsumi Y, Nakagawa S, Kiyono H, Mayumi T. PMID: 12209648.
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    268. Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis. Vaccine. 2002 Jul 26; 20(23-24):2972-80. Suenobu N, Kweon MN, Kiyono H. PMID: 12126910.
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    269. Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV. Virology. 2002 Jul 05; 298(2):306-16. Enose Y, Ui M, Miyake A, Suzuki H, Uesaka H, Kuwata T, Kunisawa J, Kiyono H, Takahashi H, Miura T, Hayami M. PMID: 12127792.
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    270. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity. 2002 Jul; 17(1):31-40. Fukuyama S, Hiroi T, Yokota Y, Rennert PD, Yanagita M, Kinoshita N, Terawaki S, Shikina T, Yamamoto M, Kurono Y, Kiyono H. PMID: 12150889.
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    271. IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation. J Immunol. 2002 Jul 01; 169(1):460-8. Ohta N, Hiroi T, Kweon MN, Kinoshita N, Jang MH, Mashimo T, Miyazaki J, Kiyono H. PMID: 12077277.
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    272. Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice. Clin Immunol. 2002 Mar; 102(3):237-48. Takahashi I, Matsuda J, Gapin L, DeWinter H, Kai Y, Tamagawa H, Kronenberg M, Kiyono H. PMID: 11890710.
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    273. Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4(+) CD45RB(+) T cells. Gut. 2002 Mar; 50(3):299-306. Kweon MN, Takahashi I, Yamamoto M, Jang MH, Suenobu N, Kiyono H. PMID: 11839705.
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    274. CD40L in autoimmunity and mucosally induced tolerance. J Clin Invest. 2002 Jan; 109(2):171-3. Kweon MN, Kiyono H. PMID: 11805128.
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    275. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol. 2002 Jan 01; 168(1):57-64. Hamada H, Hiroi T, Nishiyama Y, Takahashi H, Masunaga Y, Hachimura S, Kaminogawa S, Takahashi-Iwanaga H, Iwanaga T, Kiyono H, Yamamoto H, Ishikawa H. PMID: 11751946.
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    276. Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin. Vaccine. 2001 Dec 12; 20(5-6):756-62. Ohmura M, Yamamoto M, Kiyono H, Fujihashi K, Takeda Y, McGhee JR. PMID: 11738739.
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    277. HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions. J Immunol. 2001 Nov 15; 167(10):5862-7. Hiroi T, Goto H, Someya K, Yanagita M, Honda M, Yamanaka N, Kiyono H. PMID: 11698461.
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    278. The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J Immunol. 2001 Oct 15; 167(8):4518-26. Jones HP, Hodge LM, Fujihashi K, Kiyono H, McGhee JR, Simecka JW. PMID: 11591779.
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    279. Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE). Vaccine. 2001 Oct 12; 20(1-2):134-9. Yura M, Takahashi I, Terawaki S, Hiroi T, Kweon MN, Yuki Y, Kiyono H. PMID: 11567757.
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    280. Immunologic tolerance: the good, the bad, and the ugly. Acta Odontol Scand. 2001 Oct; 59(5):297-300. Schenck K, Kiyono H, Helgeland K, Steinsvoll S, Taylor B. PMID: 11762300.
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    281. Influence of enterotoxin on mucosal intranet: selective inhibition of extrathymic T cell development in intestinal intraepithelial lymphocytes by oral exposure to heat-labile toxin. Eur J Immunol. 2001 Oct; 31(10):2960-9. Kim JK, Takahashi I, Kai Y, Kiyono H. PMID: 11592072.
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    282. A revisit of mucosal IgA immunity and oral tolerance. Acta Odontol Scand. 2001 Oct; 59(5):301-8. Fujihashi K, Kato H, van Ginkel FW, Koga T, Boyaka PN, Jackson RJ, Kato R, Hagiwara Y, Etani Y, Goma I, Fujihashi K, Kiyono H, McGhee JR. PMID: 11680650.
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    283. Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis. J Immunol. 2001 Sep 01; 167(5):2781-90. Dohi T, Rennert PD, Fujihashi K, Kiyono H, Shirai Y, Kawamura YI, Browning JL, McGhee JR. PMID: 11509623.
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    284. Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). J Autoimmun. 2001 Aug; 17(1):17-25. Yura M, Takahashi I, Serada M, Koshio T, Nakagami K, Yuki Y, Kiyono H. PMID: 11488634.
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    285. Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system. J Immunol. 2001 Aug 01; 167(3):1406-12. Kunisawa J, Nakanishi T, Takahashi I, Okudaira A, Tsutsumi Y, Katayama K, Nakagawa S, Kiyono H, Mayumi T. PMID: 11466359.
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    286. New Frontiers in Oral Immunological Diseases. Proceedings of a Conference. Lillehammer, Norway, 23-27 February 2001. Part 2. Acta Odontol Scand. 2001 Aug; 59(4):209-11. Schenck K, Helgeland K, Kiyono H. PMID: 11699491.
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    287. NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport. 2001 Jul 20; 12(10):2079-84. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T. PMID: 11447311.
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    288. Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis. Biotechnol Bioeng. 2001 Jul 05; 74(1):62-9. Yuki Y, Byun Y, Fujita M, Izutani W, Suzuki T, Udaka S, Fujihashi K, McGhee JR, Kiyono H. PMID: 11353411.
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    289. Role of stem cell factor and c-kit signaling in regulation of fetal intestinal epithelial cell adhesion to fibronectin. Exp Cell Res. 2001 Jun 10; 266(2):311-22. Shimizu M, Minakuchi K, Tsuda A, Hiroi T, Tanaka N, Koga J, Kiyono H. PMID: 11399059.
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    290. T cell receptor dynamism of mucosal and systemic CD4+ T cells in the course of an immune response to Escherichia coli heat-labile enterotoxin. J Infect Dis. 2001 Jul 01; 184(1):43-51. Kim JK, Takahashi I, Okuda Y, Itakura M, McGhee JR, Kiyono H. PMID: 11398108.
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    291. Innate and acquired immunity, cytokines, and genetic factors in relation to the mucosal immune system. Acta Odontol Scand. 2001 Jun; 59(3):121-3. Schenck K, Kiyono H. PMID: 11501879.
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    292. The mucosal immune system: from specialized immune defense to inflammation and allergy. Acta Odontol Scand. 2001 Jun; 59(3):145-53. Kiyono H, Kweon MN, Hiroi T, Takahashi I. PMID: 11501883.
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    293. Glucocorticoid suppresses neutrophil activation in ventilator-induced lung injury. Crit Care Med. 2001 May; 29(5):1012-6. Ohta N, Shimaoka M, Imanaka H, Nishimura M, Taenaka N, Kiyono H, Yoshiya I. PMID: 11378614.
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    294. Immunoglobulin A (IgA) responses and IgE-associated inflammation along the respiratory tract after mucosal but not systemic immunization. Infect Immun. 2001 Apr; 69(4):2328-38. Hodge LM, Marinaro M, Jones HP, McGhee JR, Kiyono H, Simecka JW. PMID: 11254590.
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    295. Peyer's patches are required for oral tolerance to proteins. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3310-5. Fujihashi K, Dohi T, Rennert PD, Yamamoto M, Koga T, Kiyono H, McGhee JR. PMID: 11248075.
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    296. Genetically manipulated bacterial toxin as a new generation mucosal adjuvant. Scand J Immunol. 2001 Mar; 53(3):211-7. Yamamoto M, McGhee JR, Hagiwara Y, Otake S, Kiyono H. PMID: 11251876.
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    297. Mucosal immune network in the gut for the control of infectious diseases. Rev Med Virol. 2001 Mar-Apr; 11(2):117-33. Iijima H, Takahashi I, Kiyono H. PMID: 11262530.
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    298. [The gastrointestinal immune system: cholera toxin and E. coli heat-labile enterotoxin as immunomodulators]. Tanpakushitsu Kakusan Koso. 2001 Mar; 46(4 Suppl):547-55. Kim J, Kiyono H. PMID: 11268659.
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    299. Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies. Vaccine. 2001 Feb 28; 19(15-16):2061-70. Byun Y, Ohmura M, Fujihashi K, Yamamoto S, McGhee JR, Udaka S, Kiyono H, Takeda Y, Kohsaka T, Yuki Y. PMID: 11228378.
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    300. Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta 1 mRNA upregulation in rat lungs. Anesth Analg. 2001 Feb; 92(2):428-36. Imanaka H, Shimaoka M, Matsuura N, Nishimura M, Ohta N, Kiyono H. PMID: 11159246.
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    301. Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant. J Infect Dis. 2001 Mar 01; 183(5):823-6. Saito M, Otake S, Ohmura M, Hirasawa M, Takada K, Mega J, Takahashi I, Kiyono H, McGhee JR, Takeda Y, Yamamoto M. PMID: 11181162.
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    302. New insights into mechanism of inflammatory and allergic diseases in mucosal tissues. Digestion. 2001; 63 Suppl 1:1-11. Kweon M, Takahashi I, Kiyono H. PMID: 11173903.
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    303. Mucosal immune system: close encounter in the uncharted world of immunology. Ophthalmologica. 2001; 215 Suppl 1:22-32. Kiyono H. PMID: 11276896.
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    304. Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. Am J Pathol. 2000 Dec; 157(6):2023-35. Boyaka PN, Wright PF, Marinaro M, Kiyono H, Johnson JE, Gonzales RA, Ikizler MR, Werkhaven JA, Jackson RJ, Fujihashi K, Di Fabio S, Staats HF, McGhee JR. PMID: 11106575.
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    305. [NALT immune system for the development of AIDS mucosal vaccine]. Nihon Rinsho Meneki Gakkai Kaishi. 2000 Dec; 23(6):579-81. Kunisawa J, Sakaue G, Kiyono H. PMID: 11210747.
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    306. Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice. J Immunol. 2000 Nov 15; 165(10):5891-9. Kishi D, Takahashi I, Kai Y, Tamagawa H, Iijima H, Obunai S, Nezu R, Ito T, Matsuda H, Kiyono H. PMID: 11067950.
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    307. Evidence for early aging in the mucosal immune system. J Immunol. 2000 Nov 01; 165(9):5352-9. Koga T, McGhee JR, Kato H, Kato R, Kiyono H, Fujihashi K. PMID: 11046071.
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    308. Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses. Vaccine. 2000 Oct 15; 19(4-5):589-94. Kunisawa J, Okudaira A, Tsutusmi Y, Takahashi I, Nakanishi T, Kiyono H, Mayumi T. PMID: 11027825.
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    309. IL-15 and IL-15 receptor selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses. J Immunol. 2000 Oct 15; 165(8):4329-37. Hiroi T, Yanagita M, Ohta N, Sakaue G, Kiyono H. PMID: 11035068.
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    310. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology. 2000 Sep; 119(3):724-33. Dohi T, Fujihashi K, Kiyono H, Elson CO, McGhee JR. PMID: 10982767.
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    311. Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea. J Clin Invest. 2000 Jul; 106(2):199-206. Kweon MN, Yamamoto M, Kajiki M, Takahashi I, Kiyono H. PMID: 10903335.
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    312. Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses. J Infect Dis. 2000 Jul; 182(1):180-90. Yamamoto M, Kiyono H, Kweon MN, Yamamoto S, Fujihashi K, Kurazono H, Imaoka K, Bluethmann H, Takahashi I, Takeda Y, Azuma M, McGhee JR. PMID: 10882596.
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    313. Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J Immunol. 2000 May 15; 164(10):5184-91. Yamamoto M, Rennert P, McGhee JR, Kweon MN, Yamamoto S, Dohi T, Otake S, Bluethmann H, Fujihashi K, Kiyono H. PMID: 10799877.
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    314. Comparison of nasal and oral tolerance for the prevention of collagen induced murine arthritis. J Rheumatol. 2000 Apr; 27(4):1038-44. Higuchi K, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. PMID: 10782834.
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    315. Mucosally induced immunoglobulin E-associated inflammation in the respiratory tract. Infect Immun. 2000 Feb; 68(2):672-9. Simecka JW, Jackson RJ, Kiyono H, McGhee JR. PMID: 10639432.
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    316. Unique characteristics of lacrimal glands as a part of mucosal immune network: high frequency of IgA-committed B-1 cells and NK1.1+ alphabeta T cells. Invest Ophthalmol Vis Sci. 2000 Jan; 41(1):138-44. Saitoh-Inagawa W, Hiroi T, Yanagita M, Iijima H, Uchio E, Ohno S, Aoki K, Kiyono H. PMID: 10634613.
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    317. gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion. Int Immunol. 1999 Dec; 11(12):1907-16. Fujihashi K, Dohi T, Kweon MN, McGhee JR, Koga T, Cooper MD, Tonegawa S, Kiyono H. PMID: 10590256.
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    318. Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infect Immun. 1999 Dec; 67(12):6249-56. Pascual DW, Hone DM, Hall S, van Ginkel FW, Yamamoto M, Walters N, Fujihashi K, Powell RJ, Wu S, Vancott JL, Kiyono H, McGhee JR. PMID: 10569734.
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    319. Human interleukin-12 enhances interferon-gamma-producing influenza-specific memory CD8+ cytotoxic T lymphocytes. J Infect Dis. 1999 Nov; 180(5):1477-86. Mbawuike IN, Fujihashi K, DiFabio S, Kawabata S, McGhee JR, Couch RB, Kiyono H. PMID: 10515806.
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    320. Proliferation of donor-derived NKR-P1+TCR alpha beta + (NKT) cells in the nonrecurrent spontaneous diabetic BB rats transplanted with pancreaticoduodenal grafts of Wistar-Furth donors. Transplant Proc. 1999 Nov; 31(7):2741-2. Tori M, Ito T, Yumiba T, Okawa A, Maeda A, Sawai T, Kiyomoto T, Akamaru Y, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. PMID: 10578272.
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    321. Effects of intranasal immunization on protective immunity against otitis media. Int J Pediatr Otorhinolaryngol. 1999 Oct 05; 49 Suppl 1:S227-9. Kurono Y, Suzuki M, Mogi G, Yamamoto M, Fujihashi K, McGhee JR, Kiyono H. PMID: 10577810.
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    322. Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice. J Exp Med. 1999 Sep 06; 190(5):607-15. Iijima H, Takahashi I, Kishi D, Kim JK, Kawano S, Hori M, Kiyono H. PMID: 10477546.
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    323. A double-blind, placebo-controlled study of Mycobacterium-specific human immune responses induced by intradermal bacille Calmette-Guérin vaccination. J Lab Clin Med. 1999 Sep; 134(3):244-52. Hoft DF, Kemp EB, Marinaro M, Cruz O, Kiyono H, McGhee JR, Belisle JT, Milligan TW, Miller JP, Belshe RB. PMID: 10482309.
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    324. Gut as the largest immunologic tissue. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct; 23(5 Suppl):S7-12. Takahashi I, Kiyono H. PMID: 10483885.
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    325. Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice. J Immunol. 1999 Aug 15; 163(4):1951-7. van Ginkel FW, Wahl SM, Kearney JF, Kweon MN, Fujihashi K, Burrows PD, Kiyono H, McGhee JR. PMID: 10438931.
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    326. IL-4 production in IDDM-nonrecurrent pancreas-transplanted BB rats with donor-derived NKR-P1+TCR alpha beta + (NKT) cells, but not in IDDM-recurrent BB rats. Transplant Proc. 1999 Aug; 31(5):1940-1. Tori M, Ito T, Yumiba T, Ohkawa A, Maeda A, Sawai T, Kiyomoto T, Akamaru Y, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. PMID: 10455925.
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    327. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. J Infect Dis. 1999 Jul; 180(1):122-32. Kurono Y, Yamamoto M, Fujihashi K, Kodama S, Suzuki M, Mogi G, McGhee JR, Kiyono H. PMID: 10353870.
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    328. Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant. J Immunol. 1999 Jun 15; 162(12):7015-21. Yamamoto M, Kiyono H, Yamamoto S, Batanero E, Kweon MN, Otake S, Azuma M, Takeda Y, McGhee JR. PMID: 10358143.
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    329. Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques. J Infect Dis. 1999 May; 179 Suppl 3:S480-4. McGhee JR, Kiyono H, Kubota M, Kawabata S, Miller CJ, Lehner T, Imaoka K, Fujihashi K. PMID: 10099124.
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    330. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med. 1999 Apr 19; 189(8):1169-80. Dohi T, Fujihashi K, Rennert PD, Iwatani K, Kiyono H, McGhee JR. PMID: 10209035.
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    331. Strategies for mucosal vaccine development. Am J Trop Med Hyg. 1999 Apr; 60(4 Suppl):35-45. Boyaka PN, Marinaro M, Vancott JL, Takahashi I, Fujihashi K, Yamamoto M, van Ginkel FW, Jackson RJ, Kiyono H, McGhee JR. PMID: 10344675.
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    332. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. J Immunol. 1999 Mar 15; 162(6):3559-65. Yanagita M, Hiroi T, Kitagaki N, Hamada S, Ito HO, Shimauchi H, Murakami S, Okada H, Kiyono H. PMID: 10092814.
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    333. Immunoregulatory functions of mucosal gammadelta T cells. Microbes Infect. 1999 Mar; 1(3):241-6. Yamamoto M, Kiyono H. PMID: 10801236.
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    334. Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions. J Immunol. 1999 Feb 15; 162(4):1904-9. Kweon MN, Fujihashi K, Wakatsuki Y, Koga T, Yamamoto M, McGhee JR, Kiyono H. PMID: 9973457.
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    335. Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain- deficient mice by gut-derived antigens. J Immunol. 1999 Feb 01; 162(3):1843-50. Takahashi I, Iijima H, Katashima R, Itakura M, Kiyono H. PMID: 9973450.
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    336. Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues. Virology. 1999 Feb 01; 254(1):50-60. Nguyen HH, Moldoveanu Z, Novak MJ, van Ginkel FW, Ban E, Kiyono H, McGhee JR, Mestecky J. PMID: 9927573.
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    337. Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues. J Immunol. 1999 Jan 15; 162(2):821-8. Hiroi T, Yanagita M, Iijima H, Iwatani K, Yoshida T, Takatsu K, Kiyono H. PMID: 9916704.
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    338. Lymphocyte activation is attenuated by stellate ganglion block. Reg Anesth Pain Med. 1999 Jan-Feb; 24(1):30-5. Sugimoto M, Shimaoka M, Taenaka N, Kiyono H, Yoshiya I. PMID: 9952092.
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    339. Significant role of intragraft lymphoid tissues in preventing insulin-dependent diabetes mellitus recurrence in whole pancreaticoduodenal transplantation. Microsurgery. 1999; 19(7):338-43. Tori M, Ito T, Yumiba T, Maeda A, Sawai T, Miyasaka M, Kiyono H, Matsuda H, Nozawa M, Shirakura R. PMID: 10586200.
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    340. IL-12 is an effective adjuvant for induction of mucosal immunity. J Immunol. 1999 Jan 01; 162(1):122-8. Boyaka PN, Marinaro M, Jackson RJ, Menon S, Kiyono H, Jirillo E, McGhee JR. PMID: 9886377.
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    341. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin. J Immunol. 1999 Jan 01; 162(1):114-21. Marinaro M, Boyaka PN, Jackson RJ, Finkelman FD, Kiyono H, Jirillo E, McGhee JR. PMID: 9886376.
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    342. Oligoclonal Th2-biased betabeta T cells induce murine inflammatory bowel disease. Immunol Res. 1999; 20(3):237-42. Takahashi I, Lijima H, Kishi D, Kiyono H. PMID: 10741863.
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    343. Arginine enhances induction of T helper 1 and T helper 2 cytokine synthesis by Peyer's patch alpha beta T cells and antigen-specific mucosal immune response. Biosci Biotechnol Biochem. 1998 Dec; 62(12):2334-40. Kobayashi T, Yamamoto M, Hiroi T, McGhee J, Takeshita Y, Kiyono H. PMID: 9972259.
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    344. The influence of surgical stress on T cells: enhancement of early phase lymphocyte activation. Anesth Analg. 1998 Dec; 87(6):1431-5. Shimaoka M, Hosotsubo K, Sugimoto M, Sakaue G, Taenaka N, Yoshiya I, Kiyono H. PMID: 9842843.
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    345. Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues. J Immunol. 1998 Dec 01; 161(11):5952-8. Imaoka K, Miller CJ, Kubota M, McChesney MB, Lohman B, Yamamoto M, Fujihashi K, Someya K, Honda M, McGhee JR, Kiyono H. PMID: 9834076.
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    346. Orally administered cholera toxin prevents murine intestinal T cells from staphylococcal enterotoxin B-induced anergy. Gastroenterology. 1998 Nov; 115(5):1197-204. Iijima H, Takahashi I, Hiroi T, Shimaoka M, Kawano S, Nagano K, Hori M, Kiyono H. PMID: 9797375.
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    347. Recombinant Helicobacter pylori urease activates primary mucosal macrophages. J Infect Dis. 1998 Nov; 178(5):1516-20. Harris PR, Ernst PB, Kawabata S, Kiyono H, Graham MF, Smith PD. PMID: 9780278.
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    348. Regulation of host immune responses by modification of Salmonella virulence genes. Nat Med. 1998 Nov; 4(11):1247-52. VanCott JL, Chatfield SN, Roberts M, Hone DM, Hohmann EL, Pascual DW, Yamamoto M, Kiyono H, McGhee JR. PMID: 9809547.
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    349. Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J Immunol. 1998 Oct 15; 161(8):3974-83. Itoh M, Ishihara K, Hiroi T, Lee BO, Maeda H, Iijima H, Yanagita M, Kiyono H, Hirano T. PMID: 9780166.
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    350. A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A. J Immunol. 1998 Oct 15; 161(8):4115-21. Yamamoto M, Briles DE, Yamamoto S, Ohmura M, Kiyono H, McGhee JR. PMID: 9780183.
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    351. Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics. Gastroenterology. 1998 Oct; 115(4):866-73. Kawabata S, Boyaka PN, Coste M, Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. PMID: 9753489.
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    352. Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively. Eur J Immunol. 1998 10; 28(10):3346-53. Hiroi T, Iwatani K, Iijima H, Kodama S, Yanagita M, Kiyono H. PMID: 9808204.
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    353. Novel approaches for the induction of T helper 1 (Th1)- or Th2-type mucosal and parenteral immune responses. Expert Opin Investig Drugs. 1998 Oct; 7(10):1657-66. Marinaro M, Boyaka PN, Kiyono H, McGhee JR. PMID: 15991907.
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    354. [Dysregulation of mucosal immunity and inflammatory bowel diseases]. Nihon Rinsho. 1998 Jun; 56(6):1619-26. Dohi T, Kiyono H. PMID: 9648492.
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    355. Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. J Periodontal Res. 1998 May; 33(4):212-25. Salvi GE, Brown CE, Fujihashi K, Kiyono H, Smith FW, Beck JD, Offenbacher S. PMID: 9689617.
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    356. Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes. J Virol. 1998 May; 72(5):4534-6. Nguyen HH, Boyaka PN, Moldoveanu Z, Novak MJ, Kiyono H, McGhee JR, Mestecky J. PMID: 9557755.
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    357. Up-regulation of Fas ligand (FasL) mRNA expression in peripheral blood mononuclear cells (PBMC) after major surgery. Clin Exp Immunol. 1998 Apr; 112(1):120-5. Sugimoto M, Shimaoka M, Hosotsubo K, Tanigami H, Taenaka N, Kiyono H, Yoshiya I. PMID: 9566799.
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    358. Human milk proteins including secretory IgA fail to elicit tolerance after feeding. Int Immunol. 1998 Apr; 10(4):537-45. Yuki Y, Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. PMID: 9620610.
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    359. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J Immunol. 1998 Mar 01; 160(5):2188-96. Yamamoto M, Fujihashi K, Kawabata K, McGhee JR, Kiyono H. PMID: 9498757.
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    360. Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice. J Immunol. 1998 Feb 15; 160(4):1687-93. Kweon MN, Fujihashi K, VanCott JL, Higuchi K, Yamamoto M, McGhee JR, Kiyono H. PMID: 9469425.
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    361. Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques. J Infect Dis. 1998 Jan; 177(1):26-33. Kawabata S, Miller CJ, Lehner T, Fujihashi K, Kubota M, McGhee JR, Imaoka K, Hiroi T, Kiyono H. PMID: 9419166.
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    362. Gamma delta T cells: bodyguards and/or sleepers in the gut. Chem Immunol. 1998; 71:77-87. Takahashi I, Kiyono H. PMID: 9761948.
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    363. High mucosal levels of tumor necrosis factor alpha messenger RNA in AIDS-associated cytomegalovirus-induced esophagitis. Gastroenterology. 1998 Jan; 114(1):77-82. Wilcox CM, Harris PR, Redman TK, Kawabata S, Hiroi T, Kiyono H, Smith PD. PMID: 9428221.
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    364. Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251. AIDS. 1998 Jan 01; 12(1):1-10. Lü X, Kiyono H, Lu D, Kawabata S, Torten J, Srinivasan S, Dailey PJ, McGhee JR, Lehner T, Miller CJ. PMID: 9456249.
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    365. A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine. Biochem Biophys Res Commun. 1997 Dec 29; 241(3):797-802. Kawabata S, Boyaka PN, Coste M, Fujihashi K, Hamada S, McGhee JR, Kiyono H. PMID: 9434789.
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    366. Bacterial invasion induces interleukin-7 receptor expression in colonic epithelial cell line, T84. Eur J Immunol. 1997 Dec; 27(12):3456-60. Yamada K, Shimaoka M, Nagayama K, Hiroi T, Kiyono H, Honda T. PMID: 9464835.
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    367. Spontaneously hypertensive rat: cholera toxin converts suppression to immunity through a Th2 cell-IL-4 pathway. Am J Physiol. 1997 10; 273(4):R1509-18. Pascual DW, Coste M, Boyaka PN, Kiyono H, McGhee JR. PMID: 9362318.
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    368. An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state. Eur J Immunol. 1997 Sep; 27(9):2133-8. Fujihashi K, McGhee JR, Yamamoto M, Peschon JJ, Kiyono H. PMID: 9341750.
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    369. Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene. J Immunol. 1997 Jul 15; 159(2):685-93. van Ginkel FW, McGhee JR, Liu C, Simecka JW, Yamamoto M, Frizzell RA, Sorscher EJ, Kiyono H, Pascual DW. PMID: 9218583.
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    370. Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates. J Immunol. 1997 Jun 01; 158(11):5321-9. Kubota M, Miller CJ, Imaoka K, Kawabata S, Fujihashi K, McGhee JR, Kiyono H. PMID: 9164952.
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    371. [The mechanisms of oral tolerance]. Nihon Rinsho. 1997 Jun; 55(6):1444-9. Yamamoto M, Kweon MN, Kiyono H. PMID: 9200930.
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    372. CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice. Gastroenterology. 1997 Jun; 112(6):1876-86. Takahashi I, Kiyono H, Hamada S. PMID: 9178680.
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    373. Mucosal immunization with DNA encoding influenza hemagglutinin. Vaccine. 1997 Jun; 15(8):811-3. Ban EM, van Ginkel FW, Simecka JW, Kiyono H, Robinson HL, McGhee JR. PMID: 9234521.
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    374. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5267-72. Yamamoto S, Kiyono H, Yamamoto M, Imaoka K, Fujihashi K, Van Ginkel FW, Noda M, Takeda Y, McGhee JR. PMID: 9144226.
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    375. Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. J Exp Med. 1997 Apr 07; 185(7):1203-10. Yamamoto S, Takeda Y, Yamamoto M, Kurazono H, Imaoka K, Yamamoto M, Fujihashi K, Noda M, Kiyono H, McGhee JR. PMID: 9104807.
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    376. Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses. J Exp Med. 1997 Feb 03; 185(3):415-27. Marinaro M, Boyaka PN, Finkelman FD, Kiyono H, Jackson RJ, Jirillo E, McGhee JR. PMID: 9053442.
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    377. Oral immunization with PspA elicits protective humoral immunity against Streptococcus pneumoniae infection. Infect Immun. 1997 Feb; 65(2):640-4. Yamamoto M, McDaniel LS, Kawabata K, Briles DE, Jackson RJ, McGhee JR, Kiyono H. PMID: 9009325.
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    378. [Mucosal immune system and mucosal vaccine]. Nihon Rinsho. 1997 Feb; 55(2):492-501. Yanagita M, Hiroi T, Kiyono H. PMID: 9046845.
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    379. Helper T subsets and cytokines for mucosal immunity and tolerance. Behring Inst Mitt. 1997 Feb; (98):44-52. Vancott JL, Kweon M, Fujihashi K, Yamamoto M, Marinaro M, Kiyono H, McGhee JR. PMID: 9382768.
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    380. [Not Available]. BioDrugs. 1997 Feb; 7(2):134-57. Sabbaj S, Kiyono H, McGhee JR. PMID: 18031087.
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    381. Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections. Mol Med. 1997 Jan; 3(1):60-71. Wallace M, Scharko AM, Pauza CD, Fisch P, Imaoka K, Kawabata S, Fujihashi K, Kiyono H, Tanaka Y, Bloom BR, Malkovsky M. PMID: 9132281.
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    382. A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity. Springer Semin Immunopathol. 1997; 18(4):477-94. Fujihashi K, Kweon MN, Kiyono H, VanCott JL, van Ginkel FW, Yamamoto M, McGhee JR. PMID: 9144866.
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    383. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodontal Res. 1997 Jan; 32(1 Pt 2):115-9. Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H. PMID: 9085220.
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    384. Interleukin-12 alters helper T-cell subsets and antibody profiles induced by the mucosal adjuvant cholera toxin. Ann N Y Acad Sci. 1996 Oct 31; 795:361-5. Marinaro M, Boyaka PN, Jackson RJ, Finkelman FD, Kiyono H, McGhee JR. PMID: 8958955.
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    385. Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. J Immunol. 1996 Sep 01; 157(5):2174-85. Elson CO, Beagley KW, Sharmanov AT, Fujihashi K, Kiyono H, Tennyson GS, Cong Y, Black CA, Ridwan BW, McGhee JR. PMID: 8757344.
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    386. Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches. J Infect Dis. 1996 Jun; 173(6):1428-36. Nakagawa I, Takahashi I, Kiyono H, McGhee JR, Hamada S. PMID: 8648216.
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    387. Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect Immun. 1996 May; 64(5):1516-25. Okahashi N, Yamamoto M, Vancott JL, Chatfield SN, Roberts M, Bluethmann H, Hiroi T, Kiyono H, McGhee JR. PMID: 8613355.
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    388. Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses. J Immunol Methods. 1996 Apr 19; 190(2):189-97. Jackson RJ, Fujihashi K, Kiyono H, McGhee JR. PMID: 8621954.
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    389. Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3613-8. Fujihashi K, Kawabata S, Hiroi T, Yamamoto M, McGhee JR, Nishikawa S, Kiyono H. PMID: 8622984.
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    390. Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. Infect Immun. 1996 Apr; 64(4):1290-8. Takahashi I, Kiyono H, Jackson RJ, Fujihashi K, Staats HF, Hamada S, Clements JD, Bost KL, McGhee JR. PMID: 8606092.
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    391. Induction of pneumococcal polysaccharide-specific mucosal immune responses by oral immunization. Vaccine. 1996 Apr; 14(5):392-8. VanCott JL, Kobayashi T, Yamamoto M, Pillai S, McGhee JR, Kiyono H. PMID: 8735550.
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    392. gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses. J Exp Med. 1996 Apr 01; 183(4):1929-35. Fujihashi K, McGhee JR, Kweon MN, Cooper MD, Tonegawa S, Takahashi I, Hiroi T, Mestecky J, Kiyono H. PMID: 8666951.
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    393. Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin. J Infect Dis. 1996 Mar; 173(3):627-35. Takahashi I, Marinaro M, Kiyono H, Jackson RJ, Nakagawa I, Fujihashi K, Hamada S, Clements JD, Bost KL, McGhee JR. PMID: 8627026.
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    394. Selected Th1 and Th2 cytokine mRNA expression by CD4(+) T cells isolated from inflamed human gingival tissues. Clin Exp Immunol. 1996 Mar; 103(3):422-8. Fujihashi K, Yamamoto M, Hiroi T, Bamberg TV, McGhee JR, Kiyono H. PMID: 8608641.
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    395. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J Immunol. 1996 Feb 15; 156(4):1504-14. VanCott JL, Staats HF, Pascual DW, Roberts M, Chatfield SN, Yamamoto M, Coste M, Carter PB, Kiyono H, McGhee JR. PMID: 8568254.
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    396. Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance. Ann N Y Acad Sci. 1996 Feb 13; 778:55-63. Fujihashi K, McGhee JR, Yamamoto M, Hiroi T, Kiyono H. PMID: 8611016.
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    397. The role of Th1 and Th2 cells for mucosal IgA responses. Ann N Y Acad Sci. 1996 Feb 13; 778:64-71. Yamamoto M, Vancott JL, Okahashi N, Marinaro M, Kiyono H, Fujihashi K, Jackson RJ, Chatfield SN, Bluethmann H, McGhee JR. PMID: 8611017.
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    398. [The IgA immune system for mucosal vaccine: role of levels one and two Th2 cytokine producing T cells]. Nihon Rinsho Meneki Gakkai Kaishi. 1996 Feb; 19(1):114-8. Shimaoka M, Hiroi T, Kiyono H. PMID: 8681023.
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    399. Mucosal immunity: regulation by helper T cells and a novel method for detection. J Biotechnol. 1996 Jan 26; 44(1-3):209-16. Jackson RJ, Marinaro M, VanCott JL, Yamamoto M, Okahashi N, Fujihashi K, Kiyono H, Chatfield SN, McGhee JR. PMID: 8717406.
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    400. Soluble FcR block suppressor T cell activity at low concentration in vitro allowing isotype-specific antibody production. Cell Immunol. 1996 Jan 10; 167(1):122-8. Simpson SD, Snider DP, Zettel LA, Kiyono H, Unkeless JC, Ernst PB. PMID: 8548835.
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    401. Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases. Am J Pathol. 1996 Jan; 148(1):331-9. Yamamoto M, Kawabata K, Fujihashi K, McGhee JR, Van Dyke TE, Bamberg TV, Hiroi T, Kiyono H. PMID: 8546223.
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    402. [Immune mechanism of mucous membrane and mucous membrane vaccines: Expression of level 1 and 2 Th2-type cytokine and IgA immune response]. Nihon Rinsho Meneki Gakkai Kaishi. 1995 Dec; 18(6):690. Kiyono H. PMID: 8963788.
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    403. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol. 1995 Nov 15; 155(10):4621-9. Marinaro M, Staats HF, Hiroi T, Jackson RJ, Coste M, Boyaka PN, Okahashi N, Yamamoto M, Kiyono H, Bluethmann H, Fujihashi K, McGhee JR. PMID: 7594461.
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    404. Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells. Eur J Immunol. 1995 Oct; 25(10):2743-51. Hiroi T, Fujihashi K, McGhee JR, Kiyono H. PMID: 7589066.
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    405. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase. Hum Gene Ther. 1995 Jul; 6(7):895-903. Van Ginkel FW, Liu C, Simecka JW, Dong JY, Greenway T, Frizzell RA, Kiyono H, McGhee JR, Pascual DW. PMID: 7578408.
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    406. Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate. Nat Med. 1995 Jul; 1(7):681-5. Bukawa H, Sekigawa K, Hamajima K, Fukushima J, Yamada Y, Kiyono H, Okuda K. PMID: 7585151.
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    407. Mucosal T cells induce systemic anergy for oral tolerance. Biochem Biophys Res Commun. 1995 Jan 05; 206(1):414-20. Takahashi I, Nakagawa I, Kiyono H, McGhee JR, Clements JD, Hamada S. PMID: 7818546.
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    408. Substance P promotes Peyer's patch and splenic B cell differentiation. Adv Exp Med Biol. 1995; 371A:55-9. Pascual DW, Beagley KW, Kiyono H, McGhee JR. PMID: 8525987.
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    409. Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenes. Adv Exp Med Biol. 1995; 371A:125-8. Aicher WK, Eibel H, Fujihashi K, Boehm T, Beagley KW, McGhee JR, Kiyono H. PMID: 8525887.
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    410. Characterization of cytokine producing T cells, TCR expression, and IgA plasma cells in salivary gland-associated tissues. Adv Exp Med Biol. 1995; 371B:1103-8. Mega J, McGhee JR, Kiyono H. PMID: 7502762.
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    411. Ig-secreting and interferon-gamma-producing cells in mice mucosally immunized with influenza virus. Adv Exp Med Biol. 1995; 371B:1587-90. Novak M, Yamamoto M, Fujihashi K, Moldoveanu Z, Kiyono H, McGhee JR, Mestecky J. PMID: 7502861.
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    412. Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues. Eur J Immunol. 1994 Nov; 24(11):2653-8. Hiroi T, Fujihashi K, McGhee JR, Kiyono H. PMID: 7957557.
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    413. Oral vaccine models: multiple delivery systems employing tetanus toxoid. Ann N Y Acad Sci. 1994 Aug 15; 730:217-34. Jackson RJ, Staats HF, Xu-Amano J, Takahashi I, Kiyono H, Hudson ME, Gilley RM, Chatfield SN, McGhee JR. PMID: 8080173.
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    414. The enteric nervous and immune systems: interactions for mucosal immunity and inflammation. Immunomethods. 1994 Aug; 5(1):56-72. Pascual DW, Kiyono H, McGhee JR. PMID: 7531102.
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    415. Mucosal immunity to infection with implications for vaccine development. Curr Opin Immunol. 1994 Aug; 6(4):572-83. Staats HF, Jackson RJ, Marinaro M, Takahashi I, Kiyono H, McGhee JR. PMID: 7946045.
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    416. Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. Vaccine. 1994 Aug; 12(10):903-11. Xu-Amano J, Jackson RJ, Fujihashi K, Kiyono H, Staats HF, McGhee JR. PMID: 7975832.
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    417. Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 production, while low density T cells undergo DNA fragmentation. Eur J Immunol. 1994 Jun; 24(6):1301-6. Yamamoto M, Fujihashi K, Amano M, McGhee JR, Beagley KW, Kiyono H. PMID: 8206090.
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    418. Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells. Int Immunol. 1994 Jan; 6(1):11-9. Di Fabio S, Mbawuike IN, Kiyono H, Fujihashi K, Couch RB, McGhee JR. PMID: 8148319.
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    419. The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reprod Fertil Dev. 1994; 6(3):369-79. McGhee JR, Xu-Amano J, Miller CJ, Jackson RJ, Fujihashi K, Staats HF, Kiyono H. PMID: 7831485.
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    420. Effective mucosal immunity. Current concepts for vaccine delivery and immune response analysis. Int J Technol Assess Health Care. 1994; 10(1):93-106. McGhee JR, Kiyono H. PMID: 8157466.
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    421. Function of alpha beta TCR+ and gamma delta TCR+ IELs for the gastrointestinal immune response. Int Rev Immunol. 1994; 11(1):1-14. Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. PMID: 8057042.
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    422. alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses. J Immunol. 1993 Dec 15; 151(12):6681-91. Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. PMID: 7903096.
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    423. Function of alpha beta TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8- and CD4+CD8+ T cells for helper activity. Int Immunol. 1993 Nov; 5(11):1473-81. Fujihashi K, Yamamoto M, McGhee JR, Beagley KW, Kiyono H. PMID: 8260458.
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    424. New perspectives in mucosal immunity with emphasis on vaccine development. Semin Hematol. 1993 Oct; 30(4 Suppl 4):3-12; discussion 13-5. McGhee JR, Fujihashi K, Xu-Amano J, Jackson RJ, Elson CO, Beagley KW, Kiyono H. PMID: 8303308.
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    425. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med. 1993 Oct 01; 178(4):1309-20. Xu-Amano J, Kiyono H, Jackson RJ, Staats HF, Fujihashi K, Burrows PD, Elson CO, Pillai S, McGhee JR. PMID: 8376936.
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    426. Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect Immun. 1993 Oct; 61(10):4272-9. Jackson RJ, Fujihashi K, Xu-Amano J, Kiyono H, Elson CO, McGhee JR. PMID: 8406816.
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    427. Application of the ILISPOT-IDIP system for the enumeration of different sizes of IgA spot forming cells in the murine small and large intestine. J Immunol Methods. 1993 Aug 26; 164(1):79-90. Amano M, McGhee JR, McCutcheon MJ, Fujii K, Kiyono H. PMID: 8360511.
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    428. The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. Eur J Immunol. 1993 Aug; 23(8):2049-52. Beagley KW, Fujihashi K, Black CA, Lagoo AS, Yamamoto M, McGhee JR, Kiyono H. PMID: 8344373.
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    429. Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues. J Periodontol. 1993 May; 64(5 Suppl):400-6. Fujihashi K, Kono Y, Beagley KW, Yamamoto M, McGhee JR, Mestecky J, Kiyono H. PMID: 8315562.
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    430. Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: consequences of CD4+ and CD8+ T cell depletion. Reg Immunol. 1993 May-Aug; 5(3-4):142-50. Sarawar SR, Carding SR, Allan W, McMickle A, Fujihashi K, Kiyono H, McGhee JR, Doherty PC. PMID: 7902123.
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    431. Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells. J Immunol Methods. 1993 Apr 02; 160(2):181-9. Fujihashi K, McGhee JR, Beagley KW, McPherson DT, McPherson SA, Huang CM, Kiyono H. PMID: 8459105.
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    432. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol. 1993 Apr; 142(4):1239-50. Fujihashi K, Beagley KW, Kono Y, Aicher WK, Yamamoto M, DiFabio S, Xu-Amano J, McGhee JR, Kiyono H. PMID: 8475996.
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    433. New perspectives in vaccine development: mucosal immunity to infections. Infect Agents Dis. 1993 Apr; 2(2):55-73. McGhee JR, Kiyono H. PMID: 8162356.
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    434. Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5. J Immunol. 1993 Jan 01; 150(1):106-14. Yamamoto M, Fujihashi K, Beagley KW, McGhee JR, Kiyono H. PMID: 8417116.
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    435. Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site. Int Immunol. 1992 Sep; 4(9):959-68. Aicher WK, Fujihashi K, Yamamoto M, Kiyono H, Pitts AM, McGhee JR. PMID: 1390438.
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    436. Occurrence of antigen-specific B cells following oral or parenteral immunization with Porphyromonas gingivalis fimbriae. Int Immunol. 1992 Sep; 4(9):1003-10. Ogawa T, Kusumoto Y, Kiyono H, McGhee JR, Hamada S. PMID: 1356427.
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    437. Effects of IL6 on B cells in mucosal immune response and inflammation. Res Immunol. 1992 Sep; 143(7):744-9. Fujihashi K, Kono Y, Kiyono H. PMID: 1439148.
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    438. Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routes. AIDS Res Hum Retroviruses. 1992 Aug; 8(8):1389. McGhee JR, Yamamoto M, Kang DW, Eldridge JH, Mestecky J, Moldoveanu Z, Compans R, Kiyono H, Miller C, Marthas M. PMID: 1466963.
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    439. Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: a comparison between intravenously and genitally inoculated rhesus macaques. Clin Exp Immunol. 1992 Jun; 88(3):520-6. Miller CJ, Kang DW, Marthas M, Moldoveanu Z, Kiyono H, Marx P, Eldridge JH, Mestecky J, McGhee JR. PMID: 1606737.
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    440. Properties of IgA-binding receptors on murine T cells: relative importance of Fc alpha R, beta-galactosyltransferase and anti-secretory component reactive proteins (ASCP). Scand J Immunol. 1992 Apr; 35(4):469-86. Aicher WK, McGhee ML, McGhee JR, Moldoveanu Z, Kidd VJ, Tomana M, Mestecky J, Eldridge JH, Meyer TF, Kiyono H. PMID: 1557614.
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    441. Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues. J Immunol. 1992 Apr 01; 148(7):2030-9. Mega J, McGhee JR, Kiyono H. PMID: 1545116.
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    442. Selective induction of Th2 cells in murine Peyer's patches by oral immunization. Int Immunol. 1992 Apr; 4(4):433-45. Xu-Amano J, Aicher WK, Taguchi T, Kiyono H, McGhee JR. PMID: 1534253.
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    443. Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. J Exp Med. 1992 Mar 01; 175(3):695-707. Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone JA, Eldridge JH, Kiyono H. PMID: 1531495.
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    444. The cytokine-like action of substance P upon B cell differentiation. Reg Immunol. 1992 Mar-Apr; 4(2):100-4. Pascual DW, Bost KL, Xu-Amano J, Kiyono H, McGhee JR. PMID: 1380278.
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    445. The mucosal immune system: features of inductive and effector sites to consider in mucosal immunization and vaccine development. Reg Immunol. 1992 Mar-Apr; 4(2):54-62. Kiyono H, Bienenstock J, McGhee JR, Ernst PB. PMID: 1503889.
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    446. The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigens. Reg Immunol. 1992 Mar-Apr; 4(2):86-90. Lue C, Kiyono H, Fujihashi K, McGhee JR, Mestecky J. PMID: 1503891.
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    447. Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis. Reg Immunol. 1992 Mar-Apr; 4(2):70-8. Mega J, Fujihashi K, Kiyono H. PMID: 1354470.
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    448. Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV. J Med Primatol. 1992 Feb-May; 21(2-3):99-107. Marthas ML, Miller CJ, Sutjipto S, Higgins J, Torten J, Lohman BL, Unger RE, Ramos RA, Kiyono H, McGhee JR. PMID: 1433273.
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    449. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine. 1992; 10(2):75-88. McGhee JR, Mestecky J, Dertzbaugh MT, Eldridge JH, Hirasawa M, Kiyono H. PMID: 1539467.
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    450. Induction of T helper cells and cytokines for mucosal IgA responses. Adv Exp Med Biol. 1992; 327:107-17. Xu-Amano J, Beagley KW, Mega J, Fujihashi K, Kiyono H, McGhee JR. PMID: 1295331.
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    451. Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA response. Adv Exp Med Biol. 1992; 327:119-31. Mega J, Fujihashi K, Yamamoto M, McGhee JR, Hirasawa M, Kiyono H. PMID: 1295332.
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    452. Mucosal immunity to vaccines: current concepts for vaccine development and immune response analysis. Adv Exp Med Biol. 1992; 327:3-12. McGhee JR, Kiyono H. PMID: 1295349.
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    453. Intestinal intraepithelial lymphocyte T cells are resistant to lpr gene-induced T cell abnormalities. Eur J Immunol. 1992 Jan; 22(1):137-45. Aicher WK, Fujihashi K, Taguchi T, McGhee JR, Yamamoto M, Eldridge JH, Gay S, Kiyono H. PMID: 1346108.
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    454. Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol. 1991 Dec 01; 147(11):3736-44. Taguchi T, Aicher WK, Fujihashi K, Yamamoto M, McGhee JR, Bluestone JA, Kiyono H. PMID: 1682383.
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    455. Neuroimmune modulation of lymphocyte function--I. Substance P enhances immunoglobulin synthesis in lipopolysaccharide activated murine splenic B cell cultures. Int Immunol. 1991 Dec; 3(12):1223-9. Pascual DW, McGhee JR, Kiyono H, Bost KL. PMID: 1723293.
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    456. Immunofluorescence-digital image processing system for the quantitation of secreted immunoglobulin by single cells. J Immunol Methods. 1991 Nov 05; 144(1):127-40. Amano M, Martin JC, McGhee JR, McCutcheon MJ, Kiyono H. PMID: 1960401.
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    457. The regulation of antibody responses by mini-cytokines. Acta Neurol (Napoli). 1991 Aug; 13(4):343-9. Pascual DW, Bost KL, Xu-Amano J, Kiyono H, McGhee JR. PMID: 1723564.
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    458. Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis. J Clin Invest. 1991 Jul; 88(1):248-52. Fujihashi K, McGhee JR, Lue C, Beagley KW, Taga T, Hirano T, Kishimoto T, Mestecky J, Kiyono H. PMID: 2056119.
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    459. Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production. J Immunol. 1991 Apr 01; 146(7):2130-6. Pascual DW, Xu-Amano JC, Kiyono H, McGhee JR, Bost KL. PMID: 1706387.
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    460. Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva. J Immunol. 1991 Mar 15; 146(6):1812-21. Kono Y, Beagley KW, Fujihashi K, McGhee JR, Taga T, Hirano T, Kishimoto T, Kiyono H. PMID: 2005380.
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    461. Peyer's patch B cells with memory cell characteristics undergo terminal differentiation within 24 hours in response to interleukin-6. Cytokine. 1991 Mar; 3(2):107-16. Beagley KW, Eldridge JH, Aicher WK, Mestecky J, Di Fabio S, Kiyono H, McGhee JR. PMID: 1909587.
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    462. Porphyromonas gingivalis-specific serum IgG and IgA antibodies originate from immunoglobulin-secreting cells in inflamed gingiva. Clin Exp Immunol. 1991 Feb; 83(2):237-44. Ogawa T, Kono Y, McGhee ML, McGhee JR, Roberts JE, Hamada S, Kiyono H. PMID: 1671564.
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    463. Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells. Cell Immunol. 1991 Feb; 132(2):423-32. Lue C, Kiyono H, McGhee JR, Fujihashi K, Kishimoto T, Hirano T, Mestecky J. PMID: 1988161.
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    464. Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses. Immunol Res. 1991; 10(3-4):418-22. McGhee JR, Fujihashi K, Beagley KW, Kiyono H. PMID: 1955769.
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    465. Role of IL-6 in human antigen-specific and polyclonal IgA responses. Adv Exp Med Biol. 1991; 310:113-21. McGhee JR, Fujihashi K, Lue C, Beagley KW, Mestecky J, Kiyono H. PMID: 1808988.
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    466. Regulatory functions for murine intraepithelial lymphocytes in mucosal responses. Immunol Res. 1991; 10(3-4):324-30. Kiyono H, Fujihashi K, Taguchi T, Aicher WK, McGhee JR. PMID: 1955757.
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    467. Modulation of IgM secretion and H chain mRNA expression in CH12.LX.C4.5F5 B cells by adrenocorticotropic hormone. J Immunol. 1990 Dec 15; 145(12):4326-31. Bost KL, Clarke BL, Xu JC, Kiyono H, McGhee JR, Pascual D. PMID: 2175328.
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    468. Bacteroides gingivalis-specific serum IgG and IgA subclass antibodies in periodontal diseases. Clin Exp Immunol. 1990 Nov; 82(2):318-25. Ogawa T, Kusumoto Y, Hamada S, McGhee JR, Kiyono H. PMID: 1978704.
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    469. Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance. J Immunol. 1990 Oct 01; 145(7):2010-9. Fujihashi K, Taguchi T, McGhee JR, Eldridge JH, Bruce MG, Green DR, Singh B, Kiyono H. PMID: 1975820.
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    470. Mouse IgA Fc receptor on CD3+ T cells. Molecular forms of IgA that bind to a 38-kDa Fc alpha R protein and development of an anti-Fc alpha R antisera. J Immunol. 1990 Sep 15; 145(6):1745-53. Aicher WK, McGhee ML, McGhee JR, Eldridge JH, Beagley KW, Meyer TF, Kiyono H. PMID: 2144006.
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