Hiroshi Kiyono

Title(s)Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gut microbiota signature of pathogen-dependent dysbiosis in viral gastroenteritis. Sci Rep. 2021 Jul 06; 11(1):13945. Mizutani T, Aboagye SY, Ishizaka A, Afum T, Mensah GI, Asante-Poku A, Asandem DA, Parbie PK, Abana CZ, Kushitor D, Bonney EY, Adachi M, Hori H, Ishikawa K, Matano T, Taniguchi K, Opare D, Arhin D, Asiedu-Bekoe F, Ampofo WK, Yeboah-Manu D, Koram KA, Anang AK, Kiyono H. PMID: 34230563.
      View in: PubMed   Mentions:    Fields:    
    2. Dysbiotic Fecal Microbiome in HIV-1 Infected Individuals in Ghana. Front Cell Infect Microbiol. 2021; 11:646467. Parbie PK, Mizutani T, Ishizaka A, Kawana-Tachikawa A, Runtuwene LR, Seki S, Abana CZ, Kushitor D, Bonney EY, Ofori SB, Uematsu S, Imoto S, Kimura Y, Kiyono H, Ishikawa K, Ampofo WK, Matano T. PMID: 34084754.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci. Vaccine. 2021 May 17. Nakahashi-Ouchida R, Uchida Y, Yuki Y, Katakai Y, Yamanoue T, Ogawa H, Munesue Y, Nakano N, Hanari K, Miyazaki T, Saito Y, Umemoto S, Sawada SI, Mukerji R, Briles DE, Yasutomi Y, Akiyoshi K, Kiyono H. PMID: 34016473.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Distinct Age-Specific miRegulome Profiling of Isolated Small and Large Intestinal Epithelial Cells in Mice. Int J Mol Sci. 2021 Mar 29; 22(7). Lee J, Mohsen A, Banerjee A, McCullough LD, Mizuguchi K, Shimaoka M, Kiyono H, Park EJ. PMID: 33805523.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Angew Chem Int Ed Engl. 2021 04 26; 60(18):10023-10031. Shimoyama A, Di Lorenzo F, Yamaura H, Mizote K, Palmigiano A, Pither MD, Speciale I, Uto T, Masui S, Sturiale L, Garozzo D, Hosomi K, Shibata N, Kabayama K, Fujimoto Y, Silipo A, Kunisawa J, Kiyono H, Molinaro A, Fukase K. PMID: 33522128.
      View in: PubMed   Mentions: 3     Fields:    
    6. Characterization and Specification of a Trivalent Protein-Based Pneumococcal Vaccine Formulation Using an Adjuvant-Free Nanogel Nasal Delivery System. Mol Pharm. 2021 04 05; 18(4):1582-1592. Yuki Y, Uchida Y, Sawada SI, Nakahashi-Ouchida R, Sugiura K, Mori H, Yamanoue T, Machita T, Honma A, Kurokawa S, Mukerji R, Briles DE, Akiyoshi K, Kiyono H. PMID: 33621107.
      View in: PubMed   Mentions:    Fields:    
    7. Development of Antibody-Fragment-Producing Rice for Neutralization of Human Norovirus. Front Plant Sci. 2021; 12:639953. Sasou A, Yuki Y, Kurokawa S, Sato S, Goda Y, Uchida M, Matsumoto N, Sagara H, Watanabe Y, Kuroda M, Sakon N, Sugiura K, Nakahashi-Ouchida R, Ushijima H, Fujihashi K, Kiyono H. PMID: 33868338.
      View in: PubMed   Mentions:
    8. Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation. Nat Commun. 2021 02 16; 12(1):1067. Kurashima Y, Kigoshi T, Murasaki S, Arai F, Shimada K, Seki N, Kim YG, Hase K, Ohno H, Kawano K, Ashida H, Suzuki T, Morimoto M, Saito Y, Sasou A, Goda Y, Yuki Y, Inagaki Y, Iijima H, Suda W, Hattori M, Kiyono H. PMID: 33594081.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation. Gastroenterology. 2021 May; 160(6):2089-2102.e12. Fujimoto K, Kimura Y, Allegretti JR, Yamamoto M, Zhang YZ, Katayama K, Tremmel G, Kawaguchi Y, Shimohigoshi M, Hayashi T, Uematsu M, Yamaguchi K, Furukawa Y, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. PMID: 33577875.
      View in: PubMed   Mentions: 1     Fields:    
    10. Enzymatically polymerised polyphenols prepared from various precursors potentiate antigen-specific immune responses in both mucosal and systemic compartments in mice. PLoS One. 2021; 16(2):e0246422. Tada R, Ogasawara M, Yamanaka D, Sakurai Y, Negishi Y, Kiyono H, Ohno N, Kunisawa J, Aramaki Y. PMID: 33556119.
      View in: PubMed   Mentions: 1     Fields:    
    11. Comparative whole-genome and proteomics analyses of the next seed bank and the original master seed bank of MucoRice-CTB 51A line, a rice-based oral cholera vaccine. BMC Genomics. 2021 Jan 19; 22(1):59. Sasou A, Yuki Y, Honma A, Sugiura K, Kashima K, Kozuka-Hata H, Nojima M, Oyama M, Kurokawa S, Maruyama S, Kuroda M, Tanoue S, Takamatsu N, Fujihashi K, Goto E, Kiyono H. PMID: 33468052.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 2021 05; 14(3):640-651. Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada K, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H. PMID: 33299086.
      View in: PubMed   Mentions: 1     Fields:    
    13. Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation. Sci Rep. 2020 10 27; 10(1):18351. Matsumura S, Kurashima Y, Murasaki S, Morimoto M, Arai F, Saito Y, Katayama N, Kim D, Inagaki Y, Kudo T, Ernst PB, Shimizu T, Kiyono H. PMID: 33110098.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Lymphoid Tissue-Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells. Front Microbiol. 2020; 11:561005. Hosomi K, Shibata N, Shimoyama A, Uto T, Nagatake T, Tojima Y, Nishino T, Takeyama H, Fukase K, Kiyono H, Kunisawa J. PMID: 33101234.
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    15. The global response to the COVID-19 pandemic: how have immunology societies contributed? Nat Rev Immunol. 2020 10; 20(10):594-602. Osier F, Ting JPY, Fraser J, Lambrecht BN, Romano M, Gazzinelli RT, Bortoluci KR, Zamboni DS, Akbar AN, Evans J, Brown DE, Patel KD, Wu Y, Perez AB, Pérez O, Kamradt T, Falk C, Barda-Saad M, Ariel A, Santoni A, Annunziato F, Cassatella MA, Kiyono H, Chereshnev V, Dieye A, Mbow M, Mbengue B, Niang MDS, Suchard M. PMID: 32913283.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    16. Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcuspneumoniae-Specific IgA and Th17 Mediated Protective Immunity. Microorganisms. 2020 Jul 23; 8(8). Yoshii K, Hosomi K, Shimoyama A, Wang Y, Yamaura H, Nagatake T, Suzuki H, Lan H, Kiyono H, Fukase K, Kunisawa J. PMID: 32718009.
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    17. Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine. Vaccines (Basel). 2020 Jul 20; 8(3). Wang Y, Hosomi K, Shimoyama A, Yoshii K, Yamaura H, Nagatake T, Nishino T, Kiyono H, Fukase K, Kunisawa J. PMID: 32698404.
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    18. Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts. Cell Host Microbe. 2020 09 09; 28(3):380-389.e9. Fujimoto K, Kimura Y, Shimohigoshi M, Satoh T, Sato S, Tremmel G, Uematsu M, Kawaguchi Y, Usui Y, Nakano Y, Hayashi T, Kashima K, Yuki Y, Yamaguchi K, Furukawa Y, Kakuta M, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. PMID: 32652061.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. A Heterodimeric Antibody Fragment for Passive Immunotherapy Against Norovirus Infection. J Infect Dis. 2020 07 06; 222(3):470-478. Yuki Y, Kurokawa S, Sato S, Sasou A, Matsumoto N, Suzuki A, Sakon N, Goda Y, Takeyama N, Miyoshi T, Marcotte H, Tanaka T, Hammarstrom L, Kiyono H. PMID: 32211769.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Fecal Microbiome Composition in Healthy Adults in Ghana. Jpn J Infect Dis. 2021 Jan 22; 74(1):42-47. Parbie PK, Mizutani T, Ishizaka A, Kawana-Tachikawa A, Runtuwene LR, Seki S, Abana CZ, Kushitor D, Bonney EY, Ofori SB, Uematsu S, Imoto S, Kimura Y, Kiyono H, Ishikawa K, Ampofo WK, Matano T. PMID: 32611986.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    21. Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon. Int Immunol. 2020 04 12; 32(4):243-258. Isobe J, Maeda S, Obata Y, Iizuka K, Nakamura Y, Fujimura Y, Kimizuka T, Hattori K, Kim YG, Morita T, Kimura I, Offermanns S, Adachi T, Nakao A, Kiyono H, Takahashi D, Hase K. PMID: 31858119.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Maternal ?3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy. 2020 08; 75(8):1939-1955. Hirata SI, Nagatake T, Sawane K, Hosomi K, Honda T, Ono S, Shibuya N, Saito E, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Tomonaga T, Kiyono H, Kabashima K, Arita M, Kunisawa J. PMID: 32027039.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity. Mucosal Immunol. 2020 07; 13(4):679-690. Nakamura Y, Mimuro H, Kunisawa J, Furusawa Y, Takahashi D, Fujimura Y, Kaisho T, Kiyono H, Hase K. PMID: 32042052.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    24. Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. Int Immunol. 2020 02 07; 32(2):133-141. Takahashi I, Hosomi K, Nagatake T, Toubou H, Yamamoto D, Hayashi I, Kurashima Y, Sato S, Shibata N, Goto Y, Maruyama F, Nakagawa I, Kuwae A, Abe A, Kunisawa J, Kiyono H. PMID: 31630178.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. Essential Role of Host Double-Stranded DNA Released from Dying Cells by Cationic Liposomes for Mucosal Adjuvanticity. Vaccines (Basel). 2019 Dec 27; 8(1). Tada R, Ohshima A, Tanazawa Y, Ohmi A, Takahashi S, Kiyono H, Kunisawa J, Aramaki Y, Negishi Y. PMID: 31892192.
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    26. A role for the CCR5-CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization. Mucosal Immunol. 2019 11; 12(6):1391-1403. Joo S, Suwanto A, Sato A, Nakahashi-Ouchida R, Mori H, Uchida Y, Sato S, Kurashima Y, Yuki Y, Fujihashi K, Kawaguchi Y, Kiyono H. PMID: 31551493.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    27. Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. Immunity. 2019 09 17; 51(3):508-521.e6. Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M. PMID: 31471109.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    28. Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases. Gastroenterology. 2019 12; 157(6):1530-1543.e4. Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S. PMID: 31445037.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    29. Distinct roles for Peyer's patch B cells for induction of antigen-specific IgA antibody responses in mice administered oral recombinant Salmonella. Int Immunol. 2019 07 30; 31(8):531-541. Hashizume-Takizawa T, Shibata N, Kurashima Y, Kiyono H, Kurita-Ochiai T, Fujihashi K. PMID: 30868152.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    30. Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis. Sci Rep. 2019 07 25; 9(1):10842. Nishida K, Hasegawa A, Yamasaki S, Uchida R, Ohashi W, Kurashima Y, Kunisawa J, Kimura S, Iwanaga T, Watarai H, Hase K, Ogura H, Nakayama M, Kashiwakura JI, Okayama Y, Kubo M, Ohara O, Kiyono H, Koseki H, Murakami M, Hirano T. PMID: 31346193.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    31. Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells. Front Immunol. 2019; 10:1281. Kurashima Y, Tokuhara D, Kamioka M, Inagaki Y, Kiyono H. PMID: 31275305.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    32. Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases. Gut Microbes. 2020 05 03; 11(3):276-284. Hosomi K, Kiyono H, Kunisawa J. PMID: 31120334.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation. J Allergy Clin Immunol. 2019 09; 144(3):698-709.e9. Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H. PMID: 31125592.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice. Allergy. 2019 08; 74(8):1522-1532. Tiwari P, Nagatake T, Hirata SI, Sawane K, Saika A, Shibata Y, Morimoto S, Honda T, Adachi J, Abe Y, Isoyama J, Tomonaga T, Kiyono H, Kabashima K, Kunisawa J. PMID: 30843234.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. [MUCOSAL MULTI-ECOSYSTEM FOR THE PREVENTION AND TREATMENT OF MUCOSAL DISORDERS]. Arerugi. 2019; 68(6):675-680. Tokuhara D, Kiyono H. PMID: 31308333.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. New trends in mucosal immunology and allergy. Allergol Int. 2019 Jan; 68(1):1-3. Kiyono H, Izuhara K. PMID: 30591151.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    37. [THE MUCOSAL IMMUNE SYSTEM LEADS TO THE DEVELOPMENT OF NOVEL STRATEGY FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES]. Arerugi. 2019; 68(8):933-941. Yoshihara S, Kiyono H. PMID: 31534104.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Human Norovirus Propagation in Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells. Cell Mol Gastroenterol Hepatol. 2019; 7(3):686-688.e5. Sato S, Hisaie K, Kurokawa S, Suzuki A, Sakon N, Uchida Y, Yuki Y, Kiyono H. PMID: 30543870.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    39. A comprehensive understanding of the gut mucosal immune system in allergic inflammation. Allergol Int. 2019 Jan; 68(1):17-25. Tokuhara D, Kurashima Y, Kamioka M, Nakayama T, Ernst P, Kiyono H. PMID: 30366757.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    40. Polymeric Caffeic Acid Is a Safer Mucosal Adjuvant That Augments Antigen-Specific Mucosal and Systemic Immune Responses in Mice. Mol Pharm. 2018 09 04; 15(9):4226-4234. Tada R, Yamanaka D, Ogasawara M, Saito M, Ohno N, Kiyono H, Kunisawa J, Aramaki Y. PMID: 30107747.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    41. ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract. Int J Mol Sci. 2018 Aug 12; 19(8). Inami A, Kiyono H, Kurashima Y. PMID: 30103545.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases. Hum Vaccin Immunother. 2018; 14(9):2189-2193. Nakahashi-Ouchida R, Yuki Y, Kiyono H. PMID: 29624474.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Intranasal administration of cationic liposomes enhanced granulocyte-macrophage colony-stimulating factor expression and this expression is dispensable for mucosal adjuvant activity. BMC Res Notes. 2018 Jul 13; 11(1):472. Tada R, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y. PMID: 30005702.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    44. Nasal vaccination with pneumococcal surface protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice. Int Immunopharmacol. 2018 Aug; 61:385-393. Tada R, Suzuki H, Takahashi S, Negishi Y, Kiyono H, Kunisawa J, Aramaki Y. PMID: 29945026.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    45. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing. Int Immunol. 2018 04 03; 30(4):141-154. Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S. PMID: 29617862.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    46. Characterization of morphological conversion of Helicobacter pylori under anaerobic conditions. Microbiol Immunol. 2018 Apr; 62(4):221-228. Hirukawa S, Sagara H, Kaneto S, Kondo T, Kiga K, Sanada T, Kiyono H, Mimuro H. PMID: 29446491.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    47. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Sci Transl Med. 2018 02 21; 10(429). Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S. PMID: 29467297.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    48. Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. Sci Rep. 2018 02 13; 8(1):2904. Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J. PMID: 29440671.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsPHPublic Health
    49. Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity. Mucosal Immunol. 2018 05; 11(3):693-702. Shibata N, Kunisawa J, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K, Kiyono H. PMID: 29411777.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    50. Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents. J Hypertens. 2018 02; 36(2):387-394. Azegami T, Yuki Y, Hayashi K, Hishikawa A, Sawada SI, Ishige K, Akiyoshi K, Kiyono H, Itoh H. PMID: 28832363.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    51. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. 2018 08; 142(2):470-484.e12. Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J. PMID: 29288079.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    52. Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System. Front Immunol. 2017; 8:1787. Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H. PMID: 29321781.
      View in: PubMed   Mentions: 5     Fields:    
    53. A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. Stem Cell Reports. 2018 01 09; 10(1):314-328. Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H. PMID: 29233552.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    54. Dietary and Microbial Metabolites in the Regulation of Host Immunity. Front Microbiol. 2017; 8:2171. Shibata N, Kunisawa J, Kiyono H. PMID: 29163449.
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    55. Nanogel-based nasal vaccines for infectious and lifestyle-related diseases. Mol Immunol. 2018 06; 98:19-24. Azegami T, Yuki Y, Nakahashi R, Itoh H, Kiyono H. PMID: 29096936.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    56. Development of a nanogel-based nasal vaccine as a novel antigen delivery system. Expert Rev Vaccines. 2017 12; 16(12):1231-1240. Nakahashi-Ouchida R, Yuki Y, Kiyono H. PMID: 29053938.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    57. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. J Clin Invest. 2017 Oct 02; 127(10):3784-3795. Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y. PMID: 28891812.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    58. IL-22 induces Reg3? and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017 Oct 02; 214(10):3037-3050. Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. PMID: 28811323.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    59. Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells. EBioMedicine. 2017 Sep; 23:34-45. Takahashi Y, Sato S, Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T, Kiyono H. PMID: 28789943.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    60. Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit. Sci Rep. 2017 07 12; 7(1):5196. Ogawa T, Kashima K, Yuki Y, Mejima M, Kurokawa S, Kuroda M, Okazawa A, Kiyono H, Ohta D. PMID: 28701756.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    61. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches. Sci Rep. 2017 06 21; 7(1):3980. Kim SH, Cho BH, Kiyono H, Jang YS. PMID: 28638068.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    62. Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Immunity. 2017 05 16; 46(5):863-874.e4. Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H. PMID: 28514691.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    63. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med. 2017 06 05; 214(6):1607-1618. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H. PMID: 28512157.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    64. MicroRNA-mediated dynamic control of mucosal immunity. Int Immunol. 2017 04 01; 29(4):157-163. Park EJ, Shimaoka M, Kiyono H. PMID: 28383678.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    65. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy. PLoS One. 2017; 12(2):e0172795. Nakajima-Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, Murakami H, Hosono A, Nochi T, Wakatsuki Y, Shimojo N, Kaminogawa S, Sato R, Kiyono H, Hachimura S. PMID: 28234975.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    66. Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nat Commun. 2017 02 22; 8:14509. Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H. PMID: 28224999.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    67. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One. 2017; 12(2):e0172509. Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K. PMID: 28225814.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    68. Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice. BMC Res Notes. 2017 Jan 26; 10(1):68. Tada R, Muto S, Iwata T, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y. PMID: 28126014.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    69. Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. Annu Rev Immunol. 2017 04 26; 35:119-147. Kurashima Y, Kiyono H. PMID: 28125357.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    70. The spleen is the site where mast cells are induced in the development of food allergy. Int Immunol. 2017 01 01; 29(1):31-45. Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R. PMID: 28177443.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    71. Epithelial extracellular ATP: an initiator of immunity to parasitic infections. Immunol Cell Biol. 2017 02; 95(2):117-118. Nelson S, Kiyono H, Kurashima Y. PMID: 27874014.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    72. Epithelial glycosylation in gut homeostasis and inflammation. Nat Immunol. 2016 Oct 19; 17(11):1244-1251. Goto Y, Uematsu S, Kiyono H. PMID: 27760104.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    73. MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation. BMB Rep. 2016 May; 49(5):263-9. Lee J, Park EJ, Kiyono H. PMID: 26923304.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    74. Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism. Immunity. 2016 Mar 15; 44(3):634-646. Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF. PMID: 26982365.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    75. [MAST CELL MEDIATED HOMEOSTATIC AND BARRIER SYSTEM]. Arerugi. 2016 Mar; 65(2):104-12. Kogure Y, Kurashima Y, Kiyono H. PMID: 27086955.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    76. Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. Regul Toxicol Pharmacol. 2016 Apr; 76:128-36. Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H. PMID: 26851506.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    77. Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy. Front Nutr. 2016; 3:3. Kunisawa J, Kiyono H. PMID: 26858949.
      View in: PubMed   Mentions:
    78. The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine. Vaccine. 2016 Feb 24; 34(9):1201-7. Saito S, Ainai A, Suzuki T, Harada N, Ami Y, Yuki Y, Takeyama H, Kiyono H, Tsukada H, Hasegawa H. PMID: 26802605.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    79. Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants. . 2016 Mar; 35(3):667-79. Kashima K, Yuki Y, Mejima M, Kurokawa S, Suzuki Y, Minakawa S, Takeyama N, Fukuyama Y, Azegami T, Tanimoto T, Kuroda M, Tamura M, Gomi Y, Kiyono H. PMID: 26661780.
      View in: PubMed   Mentions:
    80. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis. Sci Rep. 2015 Dec 09; 5:18174. Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H. PMID: 26647826.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    81. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages. PLoS One. 2015; 10(11):e0142920. Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H. PMID: 26575399.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    82. IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut. Sci Rep. 2015 Nov 02; 5:15918. Goto Y, Lamichhane A, Kamioka M, Sato S, Honda K, Kunisawa J, Kiyono H. PMID: 26522513.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    83. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice. PLoS One. 2015; 10(10):e0139785. Tada R, Hidaka A, Iwase N, Takahashi S, Yamakita Y, Iwata T, Muto S, Sato E, Takayama N, Honjo E, Kiyono H, Kunisawa J, Aramaki Y. PMID: 26440657.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    84. [Roles of the gut mucosal immune system in symbiosis and immunity]. Rinsho Ketsueki. 2015 Oct; 56(10):2205-12. Goto Y, Kurashima Y, Kiyono H. PMID: 26458461.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    85. Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice. PLoS One. 2015; 10(9):e0139368. Fukuyama Y, Okada K, Yamaguchi M, Kiyono H, Mori K, Yuki Y. PMID: 26422280.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    86. Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1. Cell Rep. 2015 Oct 06; 13(1):122-131. Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M, Kiyono H. PMID: 26411688.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    87. Plant-based vaccines for animals and humans: recent advances in technology and clinical trials. Ther Adv Vaccines. 2015 Sep; 3(5-6):139-54. Takeyama N, Kiyono H, Yuki Y. PMID: 26668752.
      View in: PubMed   Mentions:
    88. Oral rice-based vaccine induces passive and active immunity against enterotoxigenic E. coli-mediated diarrhea in pigs. Vaccine. 2015 Sep 22; 33(39):5204-11. Takeyama N, Yuki Y, Tokuhara D, Oroku K, Mejima M, Kurokawa S, Kuroda M, Kodama T, Nagai S, Ueda S, Kiyono H. PMID: 26254309.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    89. Structural basis of blocking integrin activation and deactivation for anti-inflammation. J Biomed Sci. 2015 Jul 08; 22:51. Park EJ, Yuki Y, Kiyono H, Shimaoka M. PMID: 26152212.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    90. The gut microbiota and inflammatory bowel disease. Curr Opin Rheumatol. 2015 Jul; 27(4):388-96. Goto Y, Kurashima Y, Kiyono H. PMID: 26002031.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    91. Dietary ?3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep. 2015 Jun 11; 5:9750. Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. PMID: 26065911.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    92. C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine. PLoS One. 2015; 10(5):e0126352. Suzuki H, Watari A, Hashimoto E, Yonemitsu M, Kiyono H, Yagi K, Kondoh M, Kunisawa J. PMID: 26018248.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    93. Central Role of Core Binding Factor ß2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. PLoS One. 2015; 10(5):e0127460. Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H. PMID: 26001080.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    94. Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation. Mediators Inflamm. 2015; 2015:427125. Kurashima Y, Kiyono H, Kunisawa J. PMID: 25944982.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    95. Negative regulation of DSS-induced experimental colitis by PILRa. Int Immunol. 2015 Jun; 27(6):307-14. Kishida K, Kohyama M, Kurashima Y, Kogure Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H. PMID: 25710489.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    96. The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015 Feb 17; 42(2):279-293. Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K. PMID: 25692702.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    97. Comparative whole-genome analyses of selection marker-free rice-based cholera toxin B-subunit vaccine lines and wild-type lines. BMC Genomics. 2015 Feb 05; 16:48. Kashima K, Mejima M, Kurokawa S, Kuroda M, Kiyono H, Yuki Y. PMID: 25653106.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    98. The mucosal immune system: From dentistry to vaccine development. Proc Jpn Acad Ser B Phys Biol Sci. 2015; 91(8):423-39. Kiyono H, Azegami T. PMID: 26460320.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    99. Vitamins mediate immunological homeostasis and diseases at the surface of the body. Endocr Metab Immune Disord Drug Targets. 2015; 15(1):25-30. Kunisawa J, Kiyono H. PMID: 25335990.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    100. Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review. Gerontology. 2015; 61(4):336-42. Sato S, Kiyono H, Fujihashi K. PMID: 25531743.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    101. [Purinergic signaling mediates mast cell activation in intestinal inflammation]. Seikagaku. 2014 Dec; 86(6):798-802. Kurashima Y, Kiyono H, Kunisawa J. PMID: 25675821.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    102. Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease. J Immunol. 2015 Jan 01; 194(1):398-406. Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K. PMID: 25422510.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    103. Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy. PLoS One. 2014; 9(10):e107492. Nakajima-Adachi H, Kikuchi A, Fujimura Y, Shibahara K, Makino T, Goseki-Sone M, Kihara-Fujioka M, Nochi T, Kurashima Y, Igarashi O, Yamamoto M, Kunisawa J, Toda M, Kaminogawa S, Sato R, Kiyono H, Hachimura S. PMID: 25290461.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    104. Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. PLoS One. 2014; 9(9):e108294. Okura H, Sato S, Kishikawa S, Kaneto S, Nakashima T, Yoshida N, Takayanagi H, Kiyono H. PMID: 25244033.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    105. Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol. 2014 Dec; 88(23):13699-708. Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H. PMID: 25231301.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    106. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science. 2014 Sep 12; 345(6202):1254009. Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H. PMID: 25214634.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    107. Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. J Immunol. 2014 Aug 15; 193(4):1666-71. Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H. PMID: 25031459.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    108. Novel transgenic rice-based vaccines. Arch Immunol Ther Exp (Warsz). 2015 Apr; 63(2):87-99. Azegami T, Itoh H, Kiyono H, Yuki Y. PMID: 25027548.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    109. Challenges in mucosal vaccines for the control of infectious diseases. Int Immunol. 2014 Sep; 26(9):517-28. Azegami T, Yuki Y, Kiyono H. PMID: 24914172.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    110. Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine. Dig Dis Sci. 2014 Nov; 59(11):2682-92. Tokuhara D, Nochi T, Matsumura A, Mejima M, Takahashi Y, Kurokawa S, Kiyono H, Yuki Y. PMID: 24838500.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    111. Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice. Inflamm Bowel Dis. 2014 May; 20(5):790-9. Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T. PMID: 24651581.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    112. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 2014 Apr 10; 5:3704. Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. PMID: 24718324.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    113. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. Immunity. 2014 Apr 17; 40(4):530-41. Kurashima Y, Amiya T, Fujisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H. PMID: 24726878.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    114. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 2014 Mar 18; 5:3492. Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. PMID: 24637670.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsPHPublic Health
    115. Role of Lactobacillus pentosus Strain b240 and the Toll-like receptor 2 axis in Peyer's patch dendritic cell-mediated immunoglobulin A enhancement. PLoS One. 2014; 9(3):e91857. Kotani Y, Kunisawa J, Suzuki Y, Sato I, Saito T, Toba M, Kohda N, Kiyono H. PMID: 24632732.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    116. New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development. Exp Mol Med. 2014 Mar 14; 46:e83. Kurashima Y, Kiyono H. PMID: 24626169.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    117. A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. J Biotechnol. 2014 Apr 10; 175:45-52. Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H. PMID: 24548461.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    118. Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. Exp Gerontol. 2014 Jun; 54:21-6. Fujihashi K, Sato S, Kiyono H. PMID: 24440991.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    119. [The development of mucosal vaccine using bacterial function for targeting mucosal tissues]. Yakugaku Zasshi. 2014; 134(5):629-34. Suzuki H, Kondoh M, Yagi K, Kiyono H, Kunisawa J. PMID: 24790045.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    120. Interleukin 15 and CD4? T cells cooperate to promote small intestinal enteropathy in response to dietary antigen. Gastroenterology. 2014 Apr; 146(4):1017-27. Korneychuk N, Ramiro-Puig E, Ettersperger J, Schulthess J, Montcuquet N, Kiyono H, Meresse B, Cerf-Bensussan N. PMID: 24361466.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    121. Nutritional components regulate the gut immune system and its association with intestinal immune disease development. J Gastroenterol Hepatol. 2013 Dec; 28 Suppl 4:18-24. Lamichhane A, Kiyono H, Kunisawa J. PMID: 24251698.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    122. Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation. Eur J Immunol. 2013 Dec; 43(12):3108-15. Kurashima Y, Goto Y, Kiyono H. PMID: 24414823.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    123. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17808-13. Kishino S, Takeuchi M, Park SB, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J. PMID: 24127592.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    124. RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds. . 2014 Jan; 33(1):75-87. Kurokawa S, Kuroda M, Mejima M, Nakamura R, Takahashi Y, Sagara H, Takeyama N, Satoh S, Kiyono H, Teshima R, Masumura T, Yuki Y. PMID: 24085308.
      View in: PubMed   Mentions:
    125. Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. PLoS One. 2013; 8(8):e72050. Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y. PMID: 23951282.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    126. Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest. 2013 Sep; 123(9):3829-38. Tokuhara D, Álvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, Kuroda M, Oyama M, Kozuka-Hata H, Nochi T, Sagara H, Aladin F, Marcotte H, Frenken LG, Iturriza-Gómara M, Kiyono H, Hammarström L, Yuki Y. PMID: 23925294.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    127. Vitamin-mediated regulation of intestinal immunity. Front Immunol. 2013; 4:189. Kunisawa J, Kiyono H. PMID: 23874335.
      View in: PubMed   Mentions: 15     Fields:    
    128. MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of a-amylase/trypsin inhibitor-like protein family as major rice allergens. J Proteome Res. 2013 Jul 05; 12(7):3372-82. Kurokawa S, Nakamura R, Mejima M, Kozuka-Hata H, Kuroda M, Takeyama N, Oyama M, Satoh S, Kiyono H, Masumura T, Teshima R, Yuki Y. PMID: 23763241.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    129. Critical role of dendritic cells in T cell retention in the interfollicular region of Peyer's patches. J Immunol. 2013 Jul 15; 191(2):942-8. Obata T, Shibata N, Goto Y, Ishikawa I, Sato S, Kunisawa J, Kiyono H. PMID: 23772027.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    130. Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol J. 2013 Sep; 11(7):799-808. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Takahashi Y, Tokuhara D, Nochi T, Katakai Y, Kuroda M, Takeyama N, Kashima K, Abe M, Chen Y, Nakanishi U, Masumura T, Takeuchi Y, Kozuka-Hata H, Shibata H, Oyama M, Tanaka K, Kiyono H. PMID: 23601492.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsPHPublic Health
    131. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One. 2013; 8(4):e60453. Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert RS, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee JR, Fujihashi K. PMID: 23565250.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    132. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun. 2013 May; 81(5):1625-34. Kong IG, Sato A, Yuki Y, Nochi T, Takahashi H, Sawada S, Mejima M, Kurokawa S, Okada K, Sato S, Briles DE, Kunisawa J, Inoue Y, Yamamoto M, Akiyoshi K, Kiyono H. PMID: 23460513.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    133. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun. 2013; 4:1949. Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K. PMID: 23752491.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    134. Nanogel-based antigen-delivery system for nasal vaccines. Biotechnol Genet Eng Rev. 2013; 29:61-72. Yuki Y, Nochi T, Kong IG, Takahashi H, Sawada S, Akiyoshi K, Kiyono H. PMID: 24568253.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    135. Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun. 2013; 4:1772. Kunisawa J, Gohda M, Hashimoto E, Ishikawa I, Higuchi M, Suzuki Y, Goto Y, Panea C, Ivanov II, Sumiya R, Aayam L, Wake T, Tajiri S, Kurashima Y, Shikata S, Akira S, Takeda K, Kiyono H. PMID: 23612313.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCellsPHPublic Health
    136. Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol. 2013 Jan 15; 190(2):774-83. Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K. PMID: 23241884.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    137. Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4?T cells into the Th2 or Th1 phenotype. Biosci Biotechnol Biochem. 2012; 76(10):1979-81. Nakajima-Adachi H, Koike E, Totsuka M, Hiraide E, Wakatsuki Y, Kiyono H, Hachimura S. PMID: 23047087.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    138. Summary for symposium I on the development of a more efficacious influenza vaccine held at the 15th Annual Meeting of the Japanese Society for Vaccinology, Tokyo, 2011. Vaccine. 2012 Sep 28; 30(44):6338-9. Kumagai T, Kiyono H. PMID: 22906723.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    139. Immune regulation and monitoring at the epithelial surface of the intestine. Drug Discov Today. 2013 Jan; 18(1-2):87-92. Kunisawa J, Kiyono H. PMID: 22897879.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    140. Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol. 2012 Sep 15; 189(6):2869-78. Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K. PMID: 22869901.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    141. PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 2012 Oct; 24(10):613-23. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K. PMID: 22836022.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    142. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 2012 Jun 08; 336(6086):1321-5. Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D. PMID: 22674331.
      View in: PubMed   Mentions: 297     Fields:    Translation:HumansAnimalsCells
    143. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog. 2012; 8(5):e1002714. Jeon SG, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, Tsuji NM, Kiyono H, Ma JS, Kusu T, Okumura R, Hara H, Yoshida H, Yamamoto M, Nomoto K, Takeda K. PMID: 22693446.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    144. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice. J Immunol. 2012 Jun 15; 188(12):6145-55. Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Kiyono H, Ishikawa F. PMID: 22611244.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    145. RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine. Vaccine. 2012 Jun 13; 30(28):4160-6. Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Kong IG, Kuroda M, Takahashi Y, Nochi T, Tokuhara D, Kohda T, Kozaki S, Kiyono H. PMID: 22554467.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    146. The mucosal immune system of the respiratory tract. Curr Opin Virol. 2012 Jun; 2(3):225-32. Sato S, Kiyono H. PMID: 22542216.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    147. Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses. Front Immunol. 2012; 3:65. Kunisawa J, Kiyono H. PMID: 22566946.
      View in: PubMed   Mentions: 14     Fields:    
    148. Immunological function of sphingosine 1-phosphate in the intestine. Nutrients. 2012 03; 4(3):154-66. Kunisawa J, Kiyono H. PMID: 22666543.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    149. Novel vaccine development strategies for inducing mucosal immunity. Expert Rev Vaccines. 2012 Mar; 11(3):367-79. Fujkuyama Y, Tokuhara D, Kataoka K, Gilbert RS, McGhee JR, Yuki Y, Kiyono H, Fujihashi K. PMID: 22380827.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsPHPublic Health
    150. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 2012; 7(2):e32094. Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H. PMID: 22363800.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    151. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood. 2012 Mar 22; 119(12):2768-77. Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD, Ishikawa F. PMID: 22279057.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    152. Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol Rev. 2012 Jan; 245(1):147-63. Goto Y, Kiyono H. PMID: 22168418.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    153. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun. 2012; 3:1034. Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H. PMID: 22948816.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    154. [Mucosal immune systems--frontline of the biological defence mechanism]. Nihon Jibiinkoka Gakkai Kaiho. 2011 Nov; 114(11):843-50. Kiyono H, Okada K. PMID: 22295432.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    155. M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery. Eur J Immunol. 2011 Nov; 41(11):3219-29. Kim SH, Jung DI, Yang IY, Kim J, Lee KY, Nochi T, Kiyono H, Jang YS. PMID: 21887786.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    156. [Current progress in the development of mucosal vaccines]. Nihon Rinsho. 2011 Sep; 69(9):1555-60. Takeyama N, Yuki Y, Kiyono H. PMID: 21922752.
      View in: PubMed   Mentions:    Fields:    
    157. Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine. Adv Otorhinolaryngol. 2011; 72:31-6. Okada K, Yamasoba T, Kiyono H. PMID: 21865684.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    158. Host pathogens. Editorial overview. Curr Opin Immunol. 2011 Aug; 23(4):445-7. Stappenbeck T, Kiyono H. PMID: 21856138.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    159. Gut-associated lymphoid tissues for the development of oral vaccines. Adv Drug Deliv Rev. 2012 May 01; 64(6):523-30. Kunisawa J, Kurashima Y, Kiyono H. PMID: 21827802.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    160. Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy. Mol Nutr Food Res. 2011 Oct; 55(10):1475-83. Burggraf M, Nakajima-Adachi H, Hachimura S, Ilchmann A, Pemberton AD, Kiyono H, Vieths S, Toda M. PMID: 21714123.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    161. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. . 2011 May 19; 9(5):376-89. Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. PMID: 21575909.
      View in: PubMed   Mentions:
    162. Epithelial cell microRNAs in gut immunity. Nat Immunol. 2011 Mar; 12(3):195-7. Goto Y, Kiyono H. PMID: 21321589.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    163. The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J Immunol. 2011 Apr 01; 186(7):4253-62. Kim DY, Sato A, Fukuyama S, Sagara H, Nagatake T, Kong IG, Goda K, Nochi T, Kunisawa J, Sato S, Yokota Y, Lee CH, Kiyono H. PMID: 21357262.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    164. Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. . 2011 Feb 17; 9(2):83-4. Kunisawa J, Kiyono H. PMID: 21320688.
      View in: PubMed   Mentions:
    165. Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun. 2011 Jan 21; 404(3):822-8. Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H. PMID: 21172308.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    166. Mucosal regulatory cells in the gastrointestinal tract and periodontium. Periodontol 2000. 2010 Oct; 54(1):247-56. Takahashi I, Fujihashi K, Kiyono H. PMID: 20712644.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    167. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 2010 Dec; 84(24):12703-12. Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S. PMID: 20881038.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCellsPHPublic Health
    168. In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates. J Immunol. 2010 Nov 01; 185(9):5436-43. Yuki Y, Nochi T, Harada N, Katakai Y, Shibata H, Mejima M, Kohda T, Tokuhara D, Kurokawa S, Takahashi Y, Ono F, Kozaki S, Terao K, Tsukada H, Kiyono H. PMID: 20881188.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    169. High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. J Biol Chem. 2010 Oct 01; 285(40):30427-35. Omoe K, Nunomura W, Kato H, Li ZJ, Igarashi O, Araake M, Sano K, Ono HK, Abe Y, Hu DL, Nakane A, Kiyono H, Takakuwa Y, Shinagawa K, Uchiyama T, Imanishi K. PMID: 20663890.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    170. Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater. 2010 Jul; 9(7):572-8. Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K, Kiyono H. PMID: 20562880.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    171. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest. 2010 Jun; 120(6):2131-43. Malamut G, El Machhour R, Montcuquet N, Martin-Lannerée S, Dusanter-Fourt I, Verkarre V, Mention JJ, Rahmi G, Kiyono H, Butz EA, Brousse N, Cellier C, Cerf-Bensussan N, Meresse B. PMID: 20440074.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    172. Aberrant interaction of the gut immune system with environmental factors in the development of food allergies. Curr Allergy Asthma Rep. 2010 May; 10(3):215-21. Kunisawa J, Kiyono H. PMID: 20424996.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    173. Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8794-9. Tokuhara D, Yuki Y, Nochi T, Kodama T, Mejima M, Kurokawa S, Takahashi Y, Nanno M, Nakanishi U, Takaiwa F, Honda T, Kiyono H. PMID: 20421480.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCellsPHPublic Health
    174. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7419-24. Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H. PMID: 20360558.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    175. Antigen-sampling cells in the salmonid intestinal epithelium. Dev Comp Immunol. 2010 Jul; 34(7):768-74. Fuglem B, Jirillo E, Bjerkås I, Kiyono H, Nochi T, Yuki Y, Raida M, Fischer U, Koppang EO. PMID: 20178814.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    176. Role of interleukin-15 in the development of mouse olfactory nerve. Congenit Anom (Kyoto). 2009 Dec; 49(4):253-7. Umehara T, Udagawa J, Takamura K, Kimura M, Ishimitsu R, Kiyono H, Kawauchi H, Otani H. PMID: 20021484.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    177. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 2009 Nov 12; 462(7270):226-30. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H. PMID: 19907495.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    178. [The mucosal immune system: new strategy for the control of allergic diseases]. Nihon Rinsho. 2009 Nov; 67(11):2194-9. Sato A, Kiyono H. PMID: 19899540.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    179. A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity. J Immunol. 2009 Nov 15; 183(10):6538-44. Nochi T, Yuki Y, Katakai Y, Shibata H, Tokuhara D, Mejima M, Kurokawa S, Takahashi Y, Nakanishi U, Ono F, Mimuro H, Sasakawa C, Takaiwa F, Terao K, Kiyono H. PMID: 19880451.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    180. RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J Immunol. 2009 Nov 01; 183(9):5738-47. Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR. PMID: 19828638.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    181. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 2009 Oct 26; 206(11):2351-64. Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H. PMID: 19822644.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCellsPHPublic Health
    182. Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine. Histochem Cell Biol. 2009 Dec; 132(6):577-84. Suzuki R, Nourani MR, Saino-Saito S, Abe H, Nochi T, Kiyono H, Spener F, Kondo H, Owada Y. PMID: 19787366.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    183. Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine. 2009 Oct 09; 27(43):5982-8. Yuki Y, Tokuhara D, Nochi T, Yasuda H, Mejima M, Kurokawa S, Takahashi Y, Kataoka N, Nakanishi U, Hagiwara Y, Fujihashi K, Takaiwa F, Kiyono H. PMID: 19665603.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    184. Mucosal vaccines: novel advances in technology and delivery. Expert Rev Vaccines. 2009 Aug; 8(8):1083-97. Yuki Y, Kiyono H. PMID: 19627189.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    185. Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends Immunol. 2009 Jul; 30(7):334-43. Fujihashi K, Kiyono H. PMID: 19540811.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    186. New horizon of mucosal immunity and vaccines. Curr Opin Immunol. 2009 Jun; 21(3):352-8. Takahashi I, Nochi T, Yuki Y, Kiyono H. PMID: 19493665.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    187. [Recent progress for the development of mucosal vaccine]. Tanpakushitsu Kakusan Koso. 2009 Jun; 54(8 Suppl):1089-95. Nochi T, Kiyono H. PMID: 21089546.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    188. Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta. Int Arch Allergy Immunol. 2009; 150(2):164-71. Kim D, Kim SH, Park EJ, Kim J, Cho SH, Kagawa J, Arai N, Jun K, Kiyono H, Kim S. PMID: 19439982.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    189. Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun. 2009 Jun 05; 383(3):340-6. Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. PMID: 19358828.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    190. The mucosa: at the frontlines of immunity. Trends Immunol. 2008 Nov; 29(11):503-4. Fehervari Z, Kiyono H. PMID: 18838300.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    191. Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol. 2008 Nov; 29(11):505-13. Kunisawa J, Nochi T, Kiyono H. PMID: 18835748.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    192. Oral immunization: an update. Curr Opin Gastroenterol. 2008 Nov; 24(6):713-9. Mestecky J, Nguyen H, Czerkinsky C, Kiyono H. PMID: 19122521.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsPHPublic Health
    193. [MucoRice: development of rice-based oral vaccine]. Nihon Rinsho Meneki Gakkai Kaishi. 2008 Oct; 31(5):369-74. Yuki Y, Kiyono H. PMID: 18974620.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    194. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 2008 Jun 15; 180(12):7840-6. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. PMID: 18523247.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    195. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 2008 Jul; 9(7):769-76. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. PMID: 18516037.
      View in: PubMed   Mentions: 287     Fields:    Translation:AnimalsCells
    196. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice. Int Immunol. 2008 Jul; 20(7):881-91. Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K. PMID: 18492657.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    197. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol. 2008; 32(10):1211-20. Ooi EL, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. PMID: 18466972.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    198. Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis. Fish Shellfish Immunol. 2008 Sep; 25(3):315-20. Caipang CM, Verjan N, Ooi EL, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. PMID: 18603448.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    199. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2008 Jul; 25(1-2):170-80. Verjan N, Ooi EL, Nochi T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. PMID: 18499475.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    200. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol. 2008 Apr 15; 180(8):5335-43. Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H. PMID: 18390715.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    201. Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies. Infect Immun. 2008 Jun; 76(6):2777-84. Momoi F, Hashizume T, Kurita-Ochiai T, Yuki Y, Kiyono H, Yamamoto M. PMID: 18411288.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    202. Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. J Immunol. 2008 Apr 01; 180(7):4361-5. Chang SY, Cha HR, Igarashi O, Rennert PD, Kissenpfennig A, Malissen B, Nanno M, Kiyono H, Kweon MN. PMID: 18354155.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    203. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. Blood. 2008 May 01; 111(9):4646-52. Kunisawa J, Gohda M, Kurashima Y, Ishikawa I, Higuchi M, Kiyono H. PMID: 18292290.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    204. [Applicable strategies for the mucosal immune system in the regulation of allergic diseases]. Arerugi. 2008 Feb; 57(2):87-94. Kurashima Y, Kunisawa J, Kiyono H. PMID: 18349582.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    205. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol. 2008 Feb 01; 180(3):1609-18. Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN. PMID: 18209057.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    206. Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp. Infect Immun. 2008 Mar; 76(3):927-34. Hashizume T, Togawa A, Nochi T, Igarashi O, Kweon MN, Kiyono H, Yamamoto M. PMID: 18086815.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    207. A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med. 2007 Nov 26; 204(12):2789-96. Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, Kim DY, Fukuyama S, Iwatsuki-Horimoto K, Kawaoka Y, Kohda T, Kozaki S, Igarashi O, Kiyono H. PMID: 17984304.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    208. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 2007 Nov 01; 179(9):5897-906. Takamura K, Fukuyama S, Nagatake T, Kim DY, Kawamura A, Kawauchi H, Kiyono H. PMID: 17947663.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    209. Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli. Fish Shellfish Immunol. 2008 May; 24(5):506-13. Ooi EL, Verjan N, Hirono I, Nochi T, Kondo H, Aoki T, Kiyono H, Yuki Y. PMID: 18329900.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    210. Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med. 2007 Oct 01; 204(10):2335-48. Kunisawa J, Kurashima Y, Higuchi M, Gohda M, Ishikawa I, Ogahara I, Kim N, Shimizu M, Kiyono H. PMID: 17875673.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    211. Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. J Immunol. 2007 Aug 01; 179(3):1577-85. Kurashima Y, Kunisawa J, Higuchi M, Gohda M, Ishikawa I, Takayama N, Shimizu M, Kiyono H. PMID: 17641024.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    212. Progress towards an AIDS mucosal vaccine: an overview. Tuberculosis (Edinb). 2007 Aug; 87 Suppl 1:S35-44. Yuki Y, Nochi T, Kiyono H. PMID: 17652028.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    213. Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10986-91. Nochi T, Takagi H, Yuki Y, Yang L, Masumura T, Mejima M, Nakanishi U, Matsumura A, Uozumi A, Hiroi T, Morita S, Tanaka K, Takaiwa F, Kiyono H. PMID: 17573530.
      View in: PubMed   Mentions: 77     Fields:    Translation:Animals
    214. Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. J Virol. 2007 Aug; 81(15):7902-12. Ohka S, Igarashi H, Nagata N, Sakai M, Koike S, Nochi T, Kiyono H, Nomoto A. PMID: 17507470.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    215. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8971-6. Nagai S, Mimuro H, Yamada T, Baba Y, Moro K, Nochi T, Kiyono H, Suzuki T, Sasakawa C, Koyasu S. PMID: 17502608.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    216. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis. Inflamm Bowel Dis. 2007 May; 13(5):547-56. Tamagawa H, Hiroi T, Mizushima T, Ito T, Matsuda H, Kiyono H. PMID: 17245768.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    217. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007 Apr 15; 178(8):4937-46. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M. PMID: 17404275.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    218. Neuroregulator RET initiates Peyer's-patch tissue genesis. Immunity. 2007 Apr; 26(4):393-5. Fukuyama S, Kiyono H. PMID: 17459808.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    219. Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea. Clin Immunol. 2007 May; 123(2):199-208. Takayama N, Igarashi O, Kweon MN, Kiyono H. PMID: 17360239.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    220. Gut lymphocyte migration: we are halfway 'home'. Trends Immunol. 2007 Apr; 28(4):150-3. McGhee JR, Kunisawa J, Kiyono H. PMID: 17293162.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    221. [Uniqueness of the mucosal immune system for the development of prospective mucosal vaccine]. Yakugaku Zasshi. 2007 Feb; 127(2):319-26. Kunisawa J, Gohda M, Kiyono H. PMID: 17268152.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    222. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev. 2007 Feb; 215:136-53. Kunisawa J, Takahashi I, Kiyono H. PMID: 17291285.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    223. Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. Blood. 2007 May 01; 109(9):3749-56. Kunisawa J, Kurashima Y, Gohda M, Higuchi M, Ishikawa I, Miura F, Ogahara I, Kiyono H. PMID: 17234743.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCellsPHPublic Health
    224. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin Immunol. 2007 Apr; 123(1):30-9. Kim N, Kunisawa J, Kweon MN, Eog Ji G, Kiyono H. PMID: 17218154.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    225. Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine. 2007 Mar 30; 25(14):2680-7. Tanaka N, Fukuyama S, Fukuiwa T, Kawabata M, Sagara Y, Ito HO, Miwa Y, Nagatake T, Kiyono H, Kurono Y. PMID: 17270319.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    226. Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. J Immunol. 2006 Oct 15; 177(8):5524-32. Maddaloni M, Staats HF, Mierzejewska D, Hoyt T, Robinson A, Callis G, Kozaki S, Kiyono H, McGhee JR, Fujihashi K, Pascual DW. PMID: 17015739.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    227. Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J Immunol. 2006 Oct 01; 177(7):4276-80. Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, Kiyono H. PMID: 16982861.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    228. A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking. J Immunol. 2006 Sep 01; 177(5):3045-54. Hagiwara Y, Kawamura YI, Kataoka K, Rahima B, Jackson RJ, Komase K, Dohi T, Boyaka PN, Takeda Y, Kiyono H, McGhee JR, Fujihashi K. PMID: 16920941.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    229. Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J Immunol. 2006 Feb 01; 176(3):1776-83. Duverger A, Jackson RJ, van Ginkel FW, Fischer R, Tafaro A, Leppla SH, Fujihashi K, Kiyono H, McGhee JR, Boyaka PN. PMID: 16424208.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    230. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol. 2006 Jan 15; 176(2):803-10. Jang MH, Sougawa N, Tanaka T, Hirata T, Hiroi T, Tohya K, Guo Z, Umemoto E, Ebisuno Y, Yang BG, Seoh JY, Lipp M, Kiyono H, Miyasaka M. PMID: 16393963.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    231. Innate immunity in the mucosal immune system. Curr Pharm Des. 2006; 12(32):4203-13. Nochi T, Kiyono H. PMID: 17100623.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    232. Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes. Biotechnol Bioeng. 2005 Dec 30; 92(7):803-9. Yuki Y, Hara-Yakoyama C, Guadiz AA, Udaka S, Kiyono H, Chatterjee S. PMID: 16142801.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    233. A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17525-30. Takagi H, Hiroi T, Yang L, Tada Y, Yuki Y, Takamura K, Ishimitsu R, Kawauchi H, Kiyono H, Takaiwa F. PMID: 16278301.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    234. Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Curr Mol Med. 2005 Sep; 5(6):557-72. Kunisawa J, Fukuyama S, Kiyono H. PMID: 16178767.
      View in: PubMed   Mentions: 16     Fields:    
    235. Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation. Infect Immun. 2005 Jul; 73(7):4088-97. Ohmura M, Yamamoto M, Tomiyama-Miyaji C, Yuki Y, Takeda Y, Kiyono H. PMID: 15972497.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    236. Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea. J Immunol. 2005 Jun 01; 174(11):7423-32. Hino A, Fukuyama S, Kataoka K, Kweon MN, Fujihashi K, Kiyono H. PMID: 15905591.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    237. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005 May 27; 331(1):285-94. Ueta M, Hamuro J, Kiyono H, Kinoshita S. PMID: 15845391.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    238. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J Immunol. 2005 Apr 01; 174(7):4365-72. Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, Kiyono H. PMID: 15778401.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    239. Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells. Gastroenterology. 2005 Apr; 128(4):922-34. Kai Y, Takahashi I, Ishikawa H, Hiroi T, Mizushima T, Matsuda C, Kishi D, Hamada H, Tamagawa H, Ito T, Yoshizaki K, Kishimoto T, Matsuda H, Kiyono H. PMID: 15825075.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    240. [Mucosal immunology]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:14-9. Nochi T, Kiyono H. PMID: 15861629.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    241. [Host defence mechanisms offered by the mucosal immune system]. Nihon Rinsho. 2005 Apr; 63 Suppl 4:447-53. Yamamoto M, Kiyono H. PMID: 15861694.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    242. Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J Immunol. 2005 Feb 15; 174(4):1906-12. Nonaka S, Naito T, Chen H, Yamamoto M, Moro K, Kiyono H, Hamada H, Ishikawa H. PMID: 15699117.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    243. A novel neurotoxoid vaccine prevents mucosal botulism. J Immunol. 2005 Feb 15; 174(4):2190-5. Kobayashi R, Kohda T, Kataoka K, Ihara H, Kozaki S, Pascual DW, Staats HF, Kiyono H, McGhee JR, Fujihashi K. PMID: 15699151.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    244. A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. J Immunol. 2004 Dec 01; 173(11):6850-7. Yoshino N, Lü FX, Fujihashi K, Hagiwara Y, Kataoka K, Lu D, Hirst L, Honda M, van Ginkel FW, Takeda Y, Miller CJ, Kiyono H, McGhee JR. PMID: 15557179.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    245. Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium. Clin Immunol. 2004 Dec; 113(3):326-39. Nochi T, Yuki Y, Terahara K, Hino A, Kunisawa J, Kweon MN, Yamaguchi T, Kiyono H. PMID: 15507398.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    246. Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity. Vaccine. 2004 Sep 09; 22(27-28):3751-61. Ohmura-Hoshino M, Yamamoto M, Yuki Y, Takeda Y, Kiyono H. PMID: 15315856.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    247. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol. 2004 Sep 01; 173(5):3337-47. Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H. PMID: 15322197.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    248. NALT- versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol. 2004 Sep; 4(9):699-710. Kiyono H, Fukuyama S. PMID: 15343369.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    249. Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity. J Immunol. 2004 Jul 15; 173(2):762-9. Yamamoto M, Kweon MN, Rennert PD, Hiroi T, Fujihashi K, McGhee JR, Kiyono H. PMID: 15240662.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    250. IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J Immunol. 2004 May 15; 172(10):6259-64. Shikina T, Hiroi T, Iwatani K, Jang MH, Fukuyama S, Tamura M, Kubo T, Ishikawa H, Kiyono H. PMID: 15128814.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    251. Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis. Inflamm Bowel Dis. 2004 May; 10(3):182-92. Mizushima T, Ito T, Kishi D, Kai Y, Tamagawa H, Nezu R, Kiyono H, Matsuda H. PMID: 15290910.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    252. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6110-5. Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K, Sasakawa C, Suzuki T, Nochi T, Yokota Y, Rennert PD, Hiroi T, Tamagawa H, Iijima H, Kunisawa J, Yuki Y, Kiyono H. PMID: 15071180.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    253. Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea. Am J Pathol. 2004 Apr; 164(4):1327-35. Hino A, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. PMID: 15039220.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    254. [Disease condition and the mechanism of the development of type 2 diabetes mellitus]. Nihon Naika Gakkai Zasshi. 2004 Feb 20; 93 Suppl:48-51. Kiyono H. PMID: 15038121.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    255. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. J Immunol. 2003 Oct 15; 171(8):4131-9. Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki J, Kiyono H. PMID: 14530335.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    256. New generation of mucosal adjuvants for the induction of protective immunity. Rev Med Virol. 2003 Sep-Oct; 13(5):293-310. Yuki Y, Kiyono H. PMID: 12931340.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    257. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab Invest. 2003 Jul; 83(7):1045-53. Tamagawa H, Takahashi I, Furuse M, Yoshitake-Kitano Y, Tsukita S, Ito T, Matsuda H, Kiyono H. PMID: 12861044.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    258. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest. 2003 May; 111(9):1297-308. Kobayashi M, Kweon MN, Kuwata H, Schreiber RD, Kiyono H, Takeda K, Akira S. PMID: 12727921.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    259. Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells. Vaccine. 2003 Apr 02; 21(15):1613-9. Jang MH, Kweon MN, Hiroi T, Yamamoto M, Takahashi I, Kiyono H. PMID: 12639482.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    260. Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. J Immunol. 2003 Feb 15; 170(4):1754-62. Hagiwara Y, McGhee JR, Fujihashi K, Kobayashi R, Yoshino N, Kataoka K, Etani Y, Kweon MN, Tamura S, Kurata T, Takeda Y, Kiyono H, Fujihashi K. PMID: 12574339.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCellsPHPublic Health
    261. HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. J Immunol. 2003 Jan 01; 170(1):495-502. Sakaue G, Hiroi T, Nakagawa Y, Someya K, Iwatani K, Sawa Y, Takahashi H, Honda M, Kunisawa J, Kiyono H. PMID: 12496436.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    262. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. J Immunol. 2003 Jan 01; 170(1):454-62. Boyaka PN, Ohmura M, Fujihashi K, Koga T, Yamamoto M, Kweon MN, Takeda Y, Jackson RJ, Kiyono H, Yuki Y, McGhee JR. PMID: 12496431.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    263. Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells. Am J Pathol. 2003 Jan; 162(1):263-71. Okuda Y, Takahashi I, Kim JK, Ohta N, Iwatani K, Iijima H, Kai Y, Tamagawa H, Hiroi T, Kweon MN, Kawano S, Takeda K, Akira S, Sasaki Y, Hori M, Kiyono H. PMID: 12507909.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    264. Eosinophilic gastroenteritis: a problem of the mucosal immune system? Curr Allergy Asthma Rep. 2003 Jan; 3(1):79-85. Kweon MN, Kiyono H. PMID: 12542999.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    265. Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen. Vaccine. 2002 Dec 13; 21(3-4):158-66. Kawahara M, Matsuo K, Nakasone T, Hiroi T, Kiyono H, Matsumoto S, Yamada T, Yamamoto N, Honda M. PMID: 12450689.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    266. [M cells: development and function]. Tanpakushitsu Kakusan Koso. 2002 Dec; 47(16 Suppl):2325-30. Yuki Y, Kiyono H. PMID: 12518456.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    267. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. J Immunol. 2002 Dec 01; 169(11):6187-92. Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, Kiyono H. PMID: 12444123.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    268. Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K). Vaccine. 2002 Oct 04; 20(29-30):3443-55. Watanabe I, Hagiwara Y, Kadowaki SE, Yoshikawa T, Komase K, Aizawa C, Kiyono H, Takeda Y, McGhee JR, Chiba J, Sata T, Kurata T, Tamura S. PMID: 12297389.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    269. A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies. J Infect Dis. 2002 Nov 01; 186(9):1261-9. Kweon MN, Yamamoto M, Watanabe F, Tamura S, Van Ginkel FW, Miyauchi A, Takagi H, Takeda Y, Hamabata T, Fujihashi K, McGhee JR, Kiyono H. PMID: 12402195.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    270. IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):329-34. Yanagita M, Shimabukuro Y, Nozaki T, Yoshimura N, Watanabe J, Koide H, Terakura M, Saho T, Takedachi M, Jang MH, Kiyono H, Murakami S. PMID: 12237122.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    271. Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur J Immunol. 2002 Aug; 32(8):2347-55. Kunisawa J, Takahashi I, Okudaira A, Hiroi T, Katayama K, Ariyama T, Tsutsumi Y, Nakagawa S, Kiyono H, Mayumi T. PMID: 12209648.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    272. Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis. Vaccine. 2002 Jul 26; 20(23-24):2972-80. Suenobu N, Kweon MN, Kiyono H. PMID: 12126910.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    273. Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV. Virology. 2002 Jul 05; 298(2):306-16. Enose Y, Ui M, Miyake A, Suzuki H, Uesaka H, Kuwata T, Kunisawa J, Kiyono H, Takahashi H, Miura T, Hayami M. PMID: 12127792.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    274. Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity. 2002 Jul; 17(1):31-40. Fukuyama S, Hiroi T, Yokota Y, Rennert PD, Yanagita M, Kinoshita N, Terawaki S, Shikina T, Yamamoto M, Kurono Y, Kiyono H. PMID: 12150889.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    275. IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation. J Immunol. 2002 Jul 01; 169(1):460-8. Ohta N, Hiroi T, Kweon MN, Kinoshita N, Jang MH, Mashimo T, Miyazaki J, Kiyono H. PMID: 12077277.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    276. Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice. Clin Immunol. 2002 Mar; 102(3):237-48. Takahashi I, Matsuda J, Gapin L, DeWinter H, Kai Y, Tamagawa H, Kronenberg M, Kiyono H. PMID: 11890710.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    277. CD40L in autoimmunity and mucosally induced tolerance. J Clin Invest. 2002 Jan; 109(2):171-3. Kweon MN, Kiyono H. PMID: 11805128.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    278. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol. 2002 Jan 01; 168(1):57-64. Hamada H, Hiroi T, Nishiyama Y, Takahashi H, Masunaga Y, Hachimura S, Kaminogawa S, Takahashi-Iwanaga H, Iwanaga T, Kiyono H, Yamamoto H, Ishikawa H. PMID: 11751946.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
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