Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Jean Wang

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0820
    CA La Jolla 92093
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Protein Tyrosine Kinases in Leiomyomata Uteri
      NIH/NICHD R01HD046225Sep 26, 2003 - Jul 31, 2009
      Role: Principal Investigator
      Integrin Signaling in Hemostasis and Blood Diseases
      NIH/NHLBI P01HL057900Apr 1, 1997 - Jan 31, 2014
      Role: Co-Investigator
      Predoctoral and Postdoctoral Training in Cancer Cell Biology
      NIH/NCI T32CA067754Sep 25, 1995 - Jun 30, 2022
      Role: Co-Principal Investigator
      Biological Function of the Retinoblastoma Gene Product
      NIH/NCI R01CA058320May 1, 1992 - Feb 28, 2014
      Role: Principal Investigator
      FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
      NIH/NCI P01CA050528Sep 8, 1989 - Jan 31, 1998
      Role: Co-Investigator
      Nuclear Function of Abl in DNA Damage Response
      NIH/NCI R01CA043054Aug 1, 1986 - Nov 30, 2018
      Role: Principal Investigator
      Nuclear Function of the c-Abl Protooncoprotien
      NIH/NCI R37CA043054Aug 1, 1986 - Feb 25, 2008
      Role: Principal Investigator
      BASIC BIOCHEMICAL AND BIOLOGICAL MECHANISMS IN CANCER
      NIH/NCI T32CA009345Aug 1, 1984 - Nov 30, 2000
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hu WH, Miyai K, Sporn JC, Luo L, Wang J, Cosman B, Ramamoorthy S. Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm. J Clin Pathol. 2016 Jul; 69(7):627-31. PMID: 26658220.
        View in: PubMed
      2. Tu CC, Wang J. EnABLing microprocessor for apoptosis. Mol Cell Oncol. 2016; 3(2). PMID: 27182551.
        View in: PubMed
      3. Suknuntha K, Ishii Y, Tao L, Hu K, McIntosh BE, Yang D, Swanson S, Stewart R, Wang J, Thomson J, Slukvin I. Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells. Stem Cell Res. 2015 Nov; 15(3):678-93. PMID: 26561938.
        View in: PubMed
      4. Pineda G, Shen Z, de Albuquerque CP, Reynoso E, Chen J, Tu CC, Tang W, Briggs S, Zhou H, Wang J. Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain. BMC Res Notes. 2015; 8:616. PMID: 26515650.
        View in: PubMed
      5. Ishii Y, Nhiayi MK, Tse E, Cheng J, Massimino M, Durden DL, Vigneri P, Wang J. Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release. PLoS One. 2015; 10(10):e0140585. PMID: 26473951.
        View in: PubMed
      6. Tu CC, Zhong Y, Nguyen L, Tsai A, Sridevi P, Tarn WY, Wang J. The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage. Sci Signal. 2015; 8(383):ra64. PMID: 26126715.
        View in: PubMed
      7. Tonino SH, Mulkens CE, van Laar J, Derks IA, Suo G, Croon-de Boer F, van Oers MH, Eldering E, Wang J, Kater AP. Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia. Leuk Lymphoma. 2015 Aug; 56(8):2439-47. PMID: 25511680.
        View in: PubMed
      8. Manthey CF, Calabio CB, Wosinski A, Hanson EM, Vallance BA, Groisman A, Martín MG, Wang J, Eckmann L. Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions. Am J Physiol Cell Physiol. 2014 Jul 15; 307(2):C180-9. PMID: 24848114.
        View in: PubMed
      9. Suo G, Sadarangani A, Tang W, Cowan BD, Wang J. Telomerase expression abrogates rapamycin-induced irreversible growth arrest of uterine fibroid smooth muscle cells. Reprod Sci. 2014 Sep; 21(9):1161-70. PMID: 24784716.
        View in: PubMed
      10. de Souza JE, Fonseca AF, Valieris R, Carraro DM, Wang J, Kolodner RD, de Souza SJ. S-score: a scoring system for the identification and prioritization of predicted cancer genes. PLoS One. 2014; 9(4):e94147. PMID: 24710071.
        View in: PubMed
      11. Wang J. The Capable ABL: What Is Its Biological Function? Mol Cell Biol. 2014 Apr; 34(7):1188-97. PMID: 24421390.
        View in: PubMed
      12. Sridevi P, Nhiayi MK, Setten RL, Wang J. Persistent Inhibition of ABL Tyrosine Kinase Causes Enhanced Apoptotic Response to TRAIL and Disrupts the Pro-Apoptotic Effect of Chloroquine. PLoS One. 2013; 8(10):e77495. PMID: 24147007.
        View in: PubMed
      13. Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang J, Eckmann L. Trp53 deficiency protects against acute intestinal inflammation. J Immunol. 2013 Jul 15; 191(2):837-47. PMID: 23772033.
        View in: PubMed
      14. Ludwig K, Tse ES, Wang J. Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors. BMC Cancer. 2013; 13:221. PMID: 23638973.
        View in: PubMed
      15. Han J, Soletti RC, Sadarangani A, Sridevi P, Ramirez ME, Eckmann L, Borges HL, Wang J. Nuclear expression of ß-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013 Mar; 11(3):207-18. PMID: 23339186.
        View in: PubMed
      16. Han J, Sridevi P, Ramirez M, Ludwig KJ, Wang J. ß-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-a suppresses caspase-8 activation in apoptosis-resistant colon cancer cells. Mol Biol Cell. 2013 Feb; 24(4):465-73. PMID: 23264463.
        View in: PubMed
      17. Tang J, Wang J, Parker LL. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor. Chembiochem. 2012 Mar 19; 13(5):665-73. PMID: 22334513.
        View in: PubMed
      18. Wang J. Checking before changing: cell cycle checkpoints inhibit muscle differentiation. Cell Cycle. 2011 Oct 1; 10(19):3234-5. PMID: 21946520.
        View in: PubMed
      19. Bourgo RJ, Thangavel C, Ertel A, Bergseid J, McClendon AK, Wilkens L, Witkiewicz AK, Wang J, Knudsen ES. RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control. Mol Cell. 2011 Aug 19; 43(4):663-72. PMID: 21855804.
        View in: PubMed
      20. Zeitlin SG, Chapados BR, Baker NM, Tai C, Slupphaug G, Wang J. Uracil DNA N-glycosylase promotes assembly of human centromere protein A. PLoS One. 2011; 6(3):e17151. PMID: 21399697.
        View in: PubMed
      21. Preyer M, Vigneri P, Wang J. Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL. PLoS One. 2011; 6(2):e17020. PMID: 21347248.
        View in: PubMed
      22. Innocenzi A, Latella L, Messina G, Simonatto M, Marullo F, Berghella L, Poizat C, Shu CW, Wang J, Puri PL, Cossu G. An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis. EMBO Rep. 2011 Feb; 12(2):164-71. PMID: 21212806.
        View in: PubMed
      23. Jiang Y, Suo G, Sadarangani A, Cowan B, Wang J. Expression profiling of protein tyrosine kinases and their ligand activators in leiomyoma uteri. Syst Biol Reprod Med. 2010 Aug; 56(4):318-26. PMID: 20462350.
        View in: PubMed
      24. Knudsen ES, Wang J. Targeting the RB-pathway in cancer therapy. Clin Cancer Res. 2010 Feb 15; 16(4):1094-9. PMID: 20145169.
        View in: PubMed
      25. Zeitlin SG, Baker NM, Chapados BR, Soutoglou E, Wang J, Berns MW, Cleveland DW. Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15762-7. PMID: 19717431.
        View in: PubMed
      26. Huang V, Lu X, Jiang Y, Wang J. Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73. BMC Biol. 2009; 7:35. PMID: 19558638.
        View in: PubMed
      27. Suo G, Jiang Y, Cowan B, Wang J. Platelet-derived growth factor C is upregulated in human uterine fibroids and regulates uterine smooth muscle cell growth. Biol Reprod. 2009 Oct; 81(4):749-58. PMID: 19553600.
        View in: PubMed
      28. Suo G, Sadarangani A, Lamarca B, Cowan B, Wang J. Murine xenograft model for human uterine fibroids: an in vivo imaging approach. Reprod Sci. 2009 Sep; 16(9):827-42. PMID: 19516078.
        View in: PubMed
      29. Francis SM, Bergsied J, Isaac CE, Coschi CH, Martens AL, Hojilla CV, Chakrabarti S, Dimattia GE, Khoka R, Wang J, Dick FA. A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol. 2009 Aug; 29(16):4455-66. PMID: 19506017.
        View in: PubMed
      30. Stuart SA, Minami Y, Wang J. The CML stem cell: evolution of the progenitor. Cell Cycle. 2009 May 1; 8(9):1338-43. PMID: 19342894.
        View in: PubMed
      31. Lee SJ, Wang J. Exploiting the promiscuity of imatinib. J Biol. 2009; 8(3):30. PMID: 19435483.
        View in: PubMed
      32. Stuart SA, Wang J. Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells. J Biol Chem. 2009 May 29; 284(22):15061-70. PMID: 19332548.
        View in: PubMed
      33. Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang J, Naoe T. Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Int J Hematol. 2008 Dec; 88(5):471-5. PMID: 19039626.
        View in: PubMed
      34. Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang J. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17967-72. PMID: 19004799.
        View in: PubMed
      35. Huang X, Wu D, Jin H, Stupack D, Wang J. Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. J Cell Biol. 2008 Nov 17; 183(4):711-23. PMID: 19001122.
        View in: PubMed
      36. Marinovic-Terzic I, Yoshioka-Yamashita A, Shimodaira H, Avdievich E, Hunton IC, Kolodner RD, Edelmann W, Wang J. Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13993-8. PMID: 18768816.
        View in: PubMed
      37. Liu X, Shi Y, Woods KW, Hessler P, Kroeger P, Wilsbacher J, Wang J, Wang J, Li C, Li Q, Rosenberg SH, Giranda VL, Luo Y. Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression. Neoplasia. 2008 Aug; 10(8):828-37. PMID: 18670641.
        View in: PubMed
      38. Huang X, Wang J, Lu X. Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion. BMC Syst Biol. 2008; 2:49. PMID: 18549508.
        View in: PubMed
      39. Borges HL, Linden R, Wang J. DNA damage-induced cell death: lessons from the central nervous system. Cell Res. 2008 Jan; 18(1):17-26. PMID: 18087290.
        View in: PubMed
      40. Huang X, Masselli A, Frisch SM, Hunton IC, Jiang Y, Wang J. Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb. J Biol Chem. 2007 Oct 5; 282(40):29401-13. PMID: 17686781.
        View in: PubMed
      41. Jin H, Wang J. Abl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin. Mol Biol Cell. 2007 Oct; 18(10):4143-54. PMID: 17686996.
        View in: PubMed
      42. Cui H, Levesque MP, Vernoux T, Jung JW, Paquette AJ, Gallagher KL, Wang J, Blilou I, Scheres B, Benfey PN. An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. Science. 2007 Apr 20; 316(5823):421-5. PMID: 17446396.
        View in: PubMed
      43. Chau BN, Pan CW, Wang J. Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain. PLoS One. 2006; 1:e82. PMID: 17183714.
        View in: PubMed
      44. Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Kovar P, Li G, Wang G, Tao ZF, Tong Y, Lin NH, Sham HL, Wang J, Sowin TJ, Rosenberg SH, Zhang H. Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. Int J Cancer. 2006 Dec 15; 119(12):2784-94. PMID: 17019715.
        View in: PubMed
      45. Chao C, Wu Z, Mazur SJ, Borges H, Rossi M, Lin T, Wang J, Anderson CW, Appella E, Xu Y. Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol. 2006 Sep; 26(18):6859-69. PMID: 16943427.
        View in: PubMed
      46. Wang J. Eph tumour suppression: the dark side of Gleevec. Nat Cell Biol. 2006 Aug; 8(8):785-6. PMID: 16880809.
        View in: PubMed
      47. Dicker F, Kater AP, Prada CE, Fukuda T, Castro JE, Sun G, Wang J, Kipps TJ. CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53. Blood. 2006 Nov 15; 108(10):3450-7. PMID: 16741250.
        View in: PubMed
      48. Wang J, Edelmann W. Mismatch repair proteins as sensors of alkylation DNA damage. Cancer Cell. 2006 Jun; 9(6):417-8. PMID: 16766259.
        View in: PubMed
      49. Borges HL, Bird J, Wasson K, Cardiff RD, Varki N, Eckmann L, Wang J. Tumor promotion by caspase-resistant retinoblastoma protein. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15587-92. PMID: 16227443.
        View in: PubMed
      50. Naderi S, Wang J, Chen TT, Gutzkow KB, Blomhoff HK. cAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA. Mol Biol Cell. 2005 Mar; 16(3):1527-42. PMID: 15647383.
        View in: PubMed
      51. Woodring PJ, Hunter T, Wang J. Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. J Biol Chem. 2005 Mar 18; 280(11):10318-25. PMID: 15632178.
        View in: PubMed
      52. Wang J. Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress. Cell Res. 2005 Jan; 15(1):43-8. PMID: 15686626.
        View in: PubMed
      53. Li CY, Zhu J, Wang J. Ectopic expression of p73alpha, but not p73beta, suppresses myogenic differentiation. J Biol Chem. 2005 Jan 21; 280(3):2159-64. PMID: 15545283.
        View in: PubMed
      54. Woodring PJ, Meisenhelder J, Johnson SA, Zhou GL, Field J, Shah K, Bladt F, Pawson T, Niki M, Pandolfi PP, Wang J, Hunter T. c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J Cell Biol. 2004 May 24; 165(4):493-503. PMID: 15148308.
        View in: PubMed
      55. Chau BN, Chen TT, Wan YY, DeGregori J, Wang J. Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cell Biol. 2004 May; 24(10):4438-47. PMID: 15121862.
        View in: PubMed
      56. Wang J, Cho SK. Coordination of repair, checkpoint, and cell death responses to DNA damage. Adv Protein Chem. 2004; 69:101-35. PMID: 15588841.
        View in: PubMed
      57. Zhu J, Wang J. Death by Abl: a matter of location. Curr Top Dev Biol. 2004; 59:165-92. PMID: 14975251.
        View in: PubMed
      58. Wang J. Controlling Abl: auto-inhibition and co-inhibition? Nat Cell Biol. 2004 Jan; 6(1):3-7. PMID: 14704671.
        View in: PubMed
      59. Truong T, Sun G, Doorly M, Wang J, Schwartz MA. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proc Natl Acad Sci U S A. 2003 Sep 2; 100(18):10281-6. PMID: 12928501.
        View in: PubMed
      60. Guerra B, Issinger OG, Wang J. Modulation of human checkpoint kinase Chk1 by the regulatory beta-subunit of protein kinase CK2. Oncogene. 2003 Aug 7; 22(32):4933-42. PMID: 12902976.
        View in: PubMed
      61. Woodring PJ, Hunter T, Wang J. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci. 2003 Jul 1; 116(Pt 13):2613-26. PMID: 12775773.
        View in: PubMed
      62. Vella V, Zhu J, Frasca F, Li CY, Vigneri P, Vigneri R, Wang J. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J Biol Chem. 2003 Jul 4; 278(27):25151-7. PMID: 12716888.
        View in: PubMed
      63. Shimodaira H, Yoshioka-Yamashita A, Kolodner RD, Wang J. Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci U S A. 2003 Mar 4; 100(5):2420-5. PMID: 12601175.
        View in: PubMed
      64. Chau BN, Wang J. Coordinated regulation of life and death by RB. Nat Rev Cancer. 2003 Feb; 3(2):130-8. PMID: 12563312.
        View in: PubMed
      65. Zhang P, Bhakta KS, Puri PL, Newbury RO, Feramisco JR, Wang J. Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma. Cancer Biol Ther. 2003 Jan-Feb; 2(1):87-91. PMID: 12673126.
        View in: PubMed
      66. Puri PL, Bhakta K, Wood LD, Costanzo A, Zhu J, Wang J. A myogenic differentiation checkpoint activated by genotoxic stress. Nat Genet. 2002 Dec; 32(4):585-93. PMID: 12415271.
        View in: PubMed
      67. Chau BN, Borges HL, Chen TT, Masselli A, Hunton IC, Wang J. Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol. 2002 Oct; 4(10):757-65. PMID: 12360286.
        View in: PubMed
      68. Cheng K, Kurzrock R, Qiu X, Estrov Z, Ku S, Dulski KM, Wang J, Talpaz M. Reduced focal adhesion kinase and paxillin phosphorylation in BCR-ABL-transfected cells. Cancer. 2002 Jul 15; 95(2):440-50. PMID: 12124845.
        View in: PubMed
      69. Catani MV, Costanzo A, Savini I, Levrero M, de Laurenzi V, Wang J, Melino G, Avigliano L. Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. Biochem J. 2002 Jun 1; 364(Pt 2):441-7. PMID: 12023887.
        View in: PubMed
      70. Naderi S, Hunton IC, Wang J. Radiation dose-dependent maintenance of G(2) arrest requires retinoblastoma protein. Cell Cycle. 2002 May-Jun; 1(3):193-200. PMID: 12429933.
        View in: PubMed
      71. Woodring PJ, Litwack ED, O'Leary DD, Lucero GR, Wang J, Hunter T. Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol. 2002 Mar 4; 156(5):879-92. PMID: 11864995.
        View in: PubMed
      72. Wang J, Ki SW. Choosing between growth arrest and apoptosis through the retinoblastoma tumour suppressor protein, Abl and p73. Biochem Soc Trans. 2001 Nov; 29(Pt 6):666-73. PMID: 11709051.
        View in: PubMed
      73. Wang J, Naderi S, Chen TT. Role of retinoblastoma tumor suppressor protein in DNA damage response. Acta Oncol. 2001; 40(6):689-95. PMID: 11765062.
        View in: PubMed
      74. Wang J, Kolodner RD. Keystone Symposia on Molecular and Cellular Biology: 'The molecular basis of cancer'. Organizers: Carol L. Prives and George F. Vande Woude, Taos, NM, 15-21 March 1999. Biochim Biophys Acta. 2000 Feb 14; 1470(1):R21-8. PMID: 10656992.
        View in: PubMed
      75. Wang J. Cellular responses to DNA damage. Curr Opin Cell Biol. 1998 Apr; 10(2):240-7. PMID: 9561848.
        View in: PubMed
      76. Wang J. Retinoblastoma protein in growth suppression and death protection. Curr Opin Genet Dev. 1997 Feb; 7(1):39-45. PMID: 9024632.
        View in: PubMed