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Paul Insel

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0636
La Jolla CA 92093
Phone858-534-2295
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    Collapse Biography 
    Collapse Education and Training
    M.D.University of Michigan, Ann Arbor

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Caveolin-3 and cardiac fibrosis
    NIH/NIA R21AG052914Apr 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Aging and G-protein-regulated MMP14
    NIH/NIA R21AG053568Sep 30, 2016 - Apr 30, 2018
    Role: Principal Investigator
    GPCRs: novel targets in cancer-associated fibroblasts
    NIH/NCI R21CA189477Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    2011 Molecular Pharmacology GRC and GRS
    NIH/NIDA R13DA030871Jan 7, 2011 - Dec 31, 2011
    Role: Principal Investigator
    2009 Molecular Pharmacology Gordon Research Conference
    NIH/NIDA R13DA026640Mar 1, 2009 - Feb 27, 2010
    Role: Principal Investigator
    GPCRs: Evolving Concepts and Drug Discovery
    NIH/NIDA R13DA017912Mar 1, 2004 - Dec 31, 2004
    Role: Principal Investigator
    Adrenergic and Purinergic Regulation of Target Cells
    NIH/NIGMS R01GM066232Jul 1, 2002 - Aug 31, 2012
    Role: Principal Investigator
    Beta-Adrenergic Receptors of S49 Lymphoma Cells
    NIH/NIGMS R01GM061774Mar 1, 2002 - Feb 28, 2007
    Role: Principal Investigator
    Autonomic Pharmacodynamic Pharmacogenomics
    NIH U01HL069758Sep 13, 2001 - Aug 31, 2005
    Role: Co-Investigator
    Discovery and Development of Therapeutic Genes for CHF
    NIH P01HL066941Sep 29, 2000 - Jun 30, 2018
    Role: Co-Investigator
    CARDIOVASCULAR CELL GENE TRANSFER OF ADENYLYL CYCLASE
    NIH/NHLBI R01HL063885Sep 1, 2000 - Aug 31, 2004
    Role: Principal Investigator
    Sympathetic Neuroeffector Junctions &Blood Pressure
    NIH P01HL058120Jun 1, 1999 - May 31, 2012
    Role: Co-Investigator
    MOLECULAR PHYSIOLOGY OF HEART FAILURE
    NIH/NHLBI P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Co-Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    BETA-ADRENERGIC RECEPTORS IN S49 LYMPHOMA CELLS
    NIH/NIGMS R01GM040781Aug 1, 1988 - Nov 30, 1998
    Role: Principal Investigator
    RENAL ADRENERGIC RECEPTORS AND HYPERTENSION
    NIH/NHLBI R01HL035847Feb 1, 1986 - Jan 31, 1991
    Role: Principal Investigator
    CELLULAR ACTIONS OF CATECHOLAMINE RECEPTORS
    NIH/NIGMS R01GM031987Jan 1, 1983 - Jul 31, 1999
    Role: Principal Investigator
    Medical Scientist Training Program
    NIH/NIGMS T32GM007198Jul 1, 1975 - Jun 30, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Insel P, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy AM, Murray F. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Front Pharmacol. 2018; 9:431. PMID: 29872392.
      View in: PubMed
    2. Curtis MJ, Alexander S, Cirino G, Docherty JR, George CH, Giembycz MA, Hoyer D, Insel P, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Stanford SC, Teixeira MM, Wonnacott S, Ahluwalia A. Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. Br J Pharmacol. 2018 Apr; 175(7):987-993. PMID: 29520785.
      View in: PubMed
    3. Alexander SPH, Roberts RE, Broughton BRS, Sobey CG, George CH, Stanford SC, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel P, Izzo AA, Ji Y, MacEwan DJ, Mangum J, Wonnacott S, Ahluwalia A. Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology. Br J Pharmacol. 2018 02; 175(3):407-411. PMID: 29350411.
      View in: PubMed
    4. Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel P. GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J. 2018 Mar; 32(3):1170-1183. PMID: 29092903.
      View in: PubMed
    5. Sriram K, Insel P. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? Mol Pharmacol. 2018 Apr; 93(4):251-258. PMID: 29298813.
      View in: PubMed
    6. Insel P, Amara SG, Blaschke TF, Meyer UA. Introduction to the Theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development". Annu Rev Pharmacol Toxicol. 2018 Jan 06; 58:33-36. PMID: 29058990.
      View in: PubMed
    7. George CH, Stanford SC, Alexander S, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel P, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Wonnacott S, Ahluwalia A. Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts. Br J Pharmacol. 2017 Sep; 174(17):2801-2804. PMID: 28801996.
      View in: PubMed
    8. Busija AR, Patel HH, Insel P. Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C459-C477. PMID: 28122734.
      View in: PubMed
    9. Insel P, Amara SG, Blaschke TF, Meyer UA. Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology". Annu Rev Pharmacol Toxicol. 2017 Jan 06; 57:13-17. PMID: 27732830.
      View in: PubMed
    10. Sunahara RK, Insel P. The Molecular Pharmacology of G Protein Signaling Then and Now: A Tribute to Alfred G. Gilman. Mol Pharmacol. 2016 May; 89(5):585-92. PMID: 26984025.
      View in: PubMed
    11. Klepac K, Kilic A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel P, Pfeifer A. The Gq signalling pathway inhibits brown and beige adipose tissue. Nat Commun. 2016 Mar 09; 7:10895. PMID: 26955961; PMCID: PMC4786868.
    12. Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel P, Wu JC, Pruitt BL, Bernstein D. Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation. FASEB J. 2016 Apr; 30(4):1464-79. PMID: 26675706; PMCID: PMC4799510 [Available on 04/01/17].
    13. Insel P, Amara SG, Blaschke TF, Meyer UA. Introduction to the Theme "Cancer Pharmacology". Annu Rev Pharmacol Toxicol. 2016; 56:19-22. PMID: 26551200.
      View in: PubMed
    14. Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel P, Taylor SS. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12681-6. PMID: 26417071; PMCID: PMC4611605.
    15. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel P. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. PMID: 26203188; PMCID: PMC4571978.
    16. Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SP, Giembycz MA, Gilchrist A, Hoyer D, Insel P, Izzo AA, Lawrence AJ, MacEwan DJ, Moon LD, Wonnacott S, Weston AH, McGrath JC. Experimental design and analysis and their reporting: new guidance for publication in BJP. Br J Pharmacol. 2015 Jul; 172(14):3461-71. PMID: 26114403; PMCID: PMC4507152.
    17. Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel P, Milligan G, Traynelis SF. The First 50 Years of Molecular Pharmacology. Mol Pharmacol. 2015 Jul; 88(1):139-40. PMID: 25943115.
      View in: PubMed
    18. Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel P, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor. Ann Clin Transl Neurol. 2015 Jun; 2(6):595-608. PMID: 26125036; PMCID: PMC4479521.
    19. Overland AC, Insel P. Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation. J Biol Chem. 2015 Apr 17; 290(16):9941-7. PMID: 25759388; PMCID: PMC4400366.
    20. Insel P, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R. G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets. Mol Pharmacol. 2015 Jul; 88(1):181-7. PMID: 25737495; PMCID: PMC4468643.
    21. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel P, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. PMID: 25605931; PMCID: PMC4321256.
    22. Insel P, Amara SG, Blaschke TF. Introduction to the theme "Precision medicine and prediction in pharmacology". Annu Rev Pharmacol Toxicol. 2015; 55:11-4. PMID: 25562643.
      View in: PubMed
    23. Brown LM, Rogers KE, Aroonsakool N, McCammon JA, Insel P. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. J Biol Chem. 2014 Oct 17; 289(42):29148-57. PMID: 25183009; PMCID: PMC4200268.
    24. Foufelle F, Lotersztajn S, Insel P, Chevet E. AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. Am J Physiol Cell Physiol. 2014 Oct 01; 307(7):C581. PMID: 24990648.
      View in: PubMed
    25. Fridolfsson HN, Roth DM, Insel P, Patel HH. Regulation of intracellular signaling and function by caveolin. FASEB J. 2014 Sep; 28(9):3823-31. PMID: 24858278; PMCID: PMC4139902.
    26. Brown LM, Rogers KE, McCammon JA, Insel P. Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition. J Biol Chem. 2014 Mar 21; 289(12):8217-30. PMID: 24497631; PMCID: PMC3961650.
    27. Lu D, Insel P. Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C779-88. PMID: 24352335; PMCID: PMC4010809.
    28. Fuller CM, Insel P. I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?". Am J Physiol Cell Physiol. 2014 Jan 01; 306(1):C1-2. PMID: 24225885.
      View in: PubMed
    29. Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel P. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol. 2013 Dec; 84(6):787-93. PMID: 24085841; PMCID: PMC3834140.
    30. McCarty OJ, King MR, Insel P. A theme series on physical biology in cancer in AJP-Cell. Am J Physiol Cell Physiol. 2014 Jan 15; 306(2):C77. PMID: 24067917; PMCID: PMC3919984.
    31. Head BP, Patel HH, Insel P. Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochim Biophys Acta. 2014 Feb; 1838(2):532-45. PMID: 23899502; PMCID: PMC3867519.
    32. Torday JS, Insel P. AJP-Cell Physiology begins a Theme series on Evolution and Cell Physiology. Am J Physiol Cell Physiol. 2013 Oct 01; 305(7):C681. PMID: 23824845.
      View in: PubMed
    33. Goldberg C, Insel P. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training. Acad Med. 2013 Jun; 88(6):745-7. PMID: 23708597; PMCID: PMC3882192.
    34. Lu D, Insel P. Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts. J Biol Chem. 2013 Jun 28; 288(26):19040-9. PMID: 23677997; PMCID: PMC3696677.
    35. Murray F, Insel P. Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma. Expert Opin Ther Targets. 2013 Aug; 17(8):937-49. PMID: 23647244.
      View in: PubMed
    36. Lotersztajn S, Insel P. AJP-Cell begins a theme series on tissue fibrosis. Am J Physiol Cell Physiol. 2013 Feb 01; 304(3):C215. PMID: 23255579.
      View in: PubMed
    37. Guo Y, Wilderman A, Zhang L, Taylor SS, Insel P. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 2012 Nov 20; 51(46):9323-32. PMID: 23110364; PMCID: PMC3503394.
    38. Burnstock G, Insel P, Di Virgilio F. Special issue on cell and molecular biology of purinergic signalling: an introduction. Purinergic Signal. 2012 Sep; 8(3):341. PMID: 22476941; PMCID: PMC3360090.
    39. Snead AN, Insel P. Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. FASEB J. 2012 Nov; 26(11):4540-7. PMID: 22859370; PMCID: PMC3475245.
    40. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel P, Patel HH. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. PMID: 22859372; PMCID: PMC4050367.
    41. Michel MC, Insel P. Can you blame cold feet on Epac (and Rap1A)? Focus on "cyclic AMP-Rap1A signaling activates RhoA to induce a(2C)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells". Am J Physiol Cell Physiol. 2012 Sep 01; 303(5):C488-9. PMID: 22814395.
      View in: PubMed
    42. Insel P, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N. cAMP and Epac in the regulation of tissue fibrosis. Br J Pharmacol. 2012 May; 166(2):447-56. PMID: 22233238; PMCID: PMC3417479.
    43. Corriden R, Insel P. New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors. Purinergic Signal. 2012 Sep; 8(3):587-98. PMID: 22528684; PMCID: PMC3360098.
    44. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel P, Taylor SS. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. PMID: 22493239; PMCID: PMC3356610.
    45. Lu D, Soleymani S, Madakshire R, Insel P. ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors. FASEB J. 2012 Jun; 26(6):2580-91. PMID: 22415310; PMCID: PMC3360157.
    46. Wu WW, Wang G, Insel P, Hsiao CT, Zou S, Martin B, Maudsley S, Shen RF. Discovery- and target-based protein quantification using iTRAQ and pulsed Q collision induced dissociation (PQD). J Proteomics. 2012 Apr 18; 75(8):2480-7. PMID: 22397766.
      View in: PubMed
    47. Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel P, Raz E. Divergent requirement for Gas and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest. 2012 Mar; 122(3):963-73. PMID: 22326954; PMCID: PMC3287220.
    48. Rana BK, Bourne PE, Insel P. Receptor databases and computational websites for ligand binding. Methods Mol Biol. 2012; 897:1-13. PMID: 22674158.
      View in: PubMed
    49. Insel P. ß(2)-Adrenergic receptor polymorphisms and signaling: Do variants influence the "memory" of receptor activation? Sci Signal. 2011 Aug 09; 4(185):pe37. PMID: 21868355.
      View in: PubMed
    50. Zambon AC, Wilderman A, Ho A, Insel P. Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. J Biol Chem. 2011 Sep 23; 286(38):33260-7. PMID: 21808067; PMCID: PMC3190928.
    51. Peiró AM, Tang CM, Murray F, Zhang L, Brown LM, Chou D, Rassenti L, Kipps TJ, Kipps TA, Insel P. Genetic variation in phosphodiesterase (PDE) 7B in chronic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDEs in human disease. J Hum Genet. 2011 Sep; 56(9):676-81. PMID: 21796143; PMCID: PMC3833258.
    52. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel P, Roth DM, Patel HH, Patel PM. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem. 2011 Sep 23; 286(38):33310-21. PMID: 21799010; PMCID: PMC3190943.
    53. Kleyman TR, Insel P, Frank M. Editor's Note: AJP-Cell and AJP-Renal article series to honor the work of Dale Benos. Am J Physiol Cell Physiol. 2011 Oct; 301(4):C749. PMID: 21795524.
      View in: PubMed
    54. Wu WW, Wang G, Insel P, Hsiao CT, Zou S, Maudsley S, Martin B, Shen RF. Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD). J Am Soc Mass Spectrom. 2011 Oct; 22(10):1753-62. PMID: 21952889.
      View in: PubMed
    55. Creighton J, Jian M, Sayner S, Alexeyev M, Insel P. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J. 2011 Oct; 25(10):3356-65. PMID: 21680893; PMCID: PMC3177581.
    56. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel P, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011 May 31; 57(22):2273-83. PMID: 21616289; PMCID: PMC3236642.
    57. Insel P, Zhang L, Murray F, Yokouchi H, Zambon AC. Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger. Acta Physiol (Oxf). 2012 Feb; 204(2):277-87. PMID: 21385327; PMCID: PMC3125423.
    58. Rieg T, Gerasimova M, Boyer JL, Insel P, Vallon V. P2Y2 receptor activation decreases blood pressure and increases renal Na? excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R510-8. PMID: 21613580.
      View in: PubMed
    59. Zhang L, Yun H, Murray F, Lu R, Wang L, Hook V, Insel P. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cell Signal. 2011 Oct; 23(10):1611-6. PMID: 21620962; PMCID: PMC3148345.
    60. Fuhs SR, Insel P. Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization. J Biol Chem. 2011 Apr 29; 286(17):14830-41. PMID: 21362625; PMCID: PMC3083237.
    61. Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, Craig D, Kelsoe JR, Gershon ES, Leal SM, Dell Aquila M, Morris DW, Gill M, Corvin A, Insel P, McClellan J, King MC, Karayiorgou M, Levy DL, DeLisi LE, Sebat J. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 2011 Mar 24; 471(7339):499-503. PMID: 21346763; PMCID: PMC3351382.
    62. Zhang L, Murray F, Rassenti LZ, Pu M, Kelly C, Kanter JR, Greaves A, Messer K, Kipps TJ, Insel P. Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia. Int J Cancer. 2011 Sep 01; 129(5):1162-9. PMID: 21120911; PMCID: PMC3111850.
    63. Levi M, Insel P. AJP-Cell Physiology initiates publication of the Hans H. Ussing Lecture. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1221. PMID: 20881237.
      View in: PubMed
    64. Rieg T, Tang T, Murray F, Schroth J, Insel P, Fenton RA, Hammond HK, Vallon V. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol. 2010 Dec; 21(12):2059-68. PMID: 20864687; PMCID: PMC3014019.
    65. Stockand JD, Mironova E, Bugaj V, Rieg T, Insel P, Vallon V, Peti-Peterdi J, Pochynyuk O. Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol. 2010 Nov; 21(11):1903-11. PMID: 20813869; PMCID: PMC3014005.
    66. Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel P, Junger WG. Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood. 2010 Nov 04; 116(18):3475-84. PMID: 20660288; PMCID: PMC2981474.
    67. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel P, Giles WR, Taylor SS, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 03; 285(36):27632-40. PMID: 20581396; PMCID: PMC2934631.
    68. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel P, Webster NJ, Guiney DG, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. PMID: 20479237; PMCID: PMC2890829.
    69. Braun OO, Lu D, Aroonsakool N, Insel P. Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors. J Mol Cell Cardiol. 2010 Sep; 49(3):362-9. PMID: 20471392; PMCID: PMC2917486.
    70. Insel P. Historical perspectives in cell physiology: looking back to help the discipline move forward. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1279. PMID: 20237145.
      View in: PubMed
    71. Choi LJ, Jenikova G, Hanson E, Spehlmann ME, Boehling NS, Kirstein SL, Bundey RA, Smith JR, Insel P, Eckmann L. Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G protein (G(s)) in intestinal epithelial cell differentiation. J Biol Chem. 2010 Apr 23; 285(17):12504-11. PMID: 20157112; PMCID: PMC2857080.
    72. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel P, Stockand JD, Vallon V. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J. 2010 Jun; 24(6):2056-65. PMID: 20097874; PMCID: PMC2874475.
    73. Lotersztajn S, Insel P. American Journal of Physiology-Cell Physiology initiates a series of articles around a theme: autophagy is the first theme. Am J Physiol Cell Physiol. 2010 Apr; 298(4):C775. PMID: 20071687.
      View in: PubMed
    74. Corriden R, Insel P. Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal. 2010 Jan 12; 3(104):re1. PMID: 20068232; PMCID: PMC3085344.
    75. Braun OO, Insel P. The best "model system" for human (coronary arteries) is human. J Am Coll Cardiol. 2009 Sep 22; 54(13):1146-8. PMID: 19761934.
      View in: PubMed
    76. Fung MM, Rana BK, Tang CM, Shiina T, Nievergelt CM, Rao F, Salem RM, Waalen J, Ziegler MG, Insel P, O'Connor DT. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Kidney Int. 2009 Nov; 76(10):1070-80. PMID: 19675531; PMCID: PMC2803094.
    77. Patel HH, Insel P. Lipid rafts and caveolae and their role in compartmentation of redox signaling. Antioxid Redox Signal. 2009 Jun; 11(6):1357-72. PMID: 19061440; PMCID: PMC2757136.
    78. Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel P, Junger WG. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J. 2009 Jun; 23(6):1685-93. PMID: 19211924; PMCID: PMC2718802.
    79. Insel P, Patel HH. Membrane rafts and caveolae in cardiovascular signaling. Curr Opin Nephrol Hypertens. 2009 Jan; 18(1):50-6. PMID: 19077689; PMCID: PMC2757134.
    80. Dong X, Smoll EJ, Ko KH, Lee J, Chow JY, Kim HD, Insel P, Dong H. P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G424-32. PMID: 19074643; PMCID: PMC2643905.
    81. Zhang L, Murray F, Zahno A, Kanter JR, Chou D, Suda R, Fenlon M, Rassenti L, Cottam H, Kipps TJ, Insel P. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19532-7. PMID: 19033455; PMCID: PMC2614795.
    82. Pochynyuk O, Bugaj V, Rieg T, Insel P, Mironova E, Vallon V, Stockand JD. Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem. 2008 Dec 26; 283(52):36599-607. PMID: 18981175; PMCID: PMC2605978.
    83. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel P, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation. 2008 Nov 04; 118(19):1979-88. PMID: 18936328; PMCID: PMC2676165.
    84. Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel P, Junger WG. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem. 2008 Oct 17; 283(42):28480-6. PMID: 18713747; PMCID: PMC2568933.
    85. Schach C, Firth AL, Xu M, Remillard CV, Patel HH, Insel P, Yuan JX. Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp Lung Res. 2008 May; 34(4):195-208. PMID: 18432456.
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    86. Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel P. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6386-91. PMID: 18434542; PMCID: PMC2359804.
    87. Rieg T, Pothula K, Schroth J, Satriano J, Osswald H, Schnermann J, Insel P, Bundey RA, Vallon V. Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F638-44. PMID: 18199602.
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    88. Patel HH, Murray F, Insel P. Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol. 2008; 48:359-91. PMID: 17914930; PMCID: PMC3083858.
    89. Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel P. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J Biol Chem. 2008 Feb 15; 283(7):4304-13. PMID: 18048352; PMCID: PMC3882191.
    90. Horikawa YT, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel P, Roth DM. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol. 2008 Jan; 44(1):123-30. PMID: 18054955; PMCID: PMC2701396.
    91. Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel P, Roth DM, Drummond JC, Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 2008 Mar; 22(3):828-40. PMID: 17905724.
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    92. Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel P, Roth DM. Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3216-20. PMID: 17873016.
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    93. Insel P. British Pharmacology Society 2nd Focused meeting on Cell Signalling: GPCRs have sunny days in springtime Leicester. Expert Opin Ther Targets. 2007 Sep; 11(9):1251-3. PMID: 17845149.
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    94. Corriden R, Insel P, Junger WG. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1420-5. PMID: 17699635.
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    95. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel P, Vallon V. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J. 2007 Nov; 21(13):3717-26. PMID: 17575258.
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    96. Steagall WK, Barrow BJ, Glasgow CG, Mendoza JW, Ehrmantraut M, Lin JP, Insel P, Moss J. Beta-2-adrenergic receptor polymorphisms in cystic fibrosis. Pharmacogenet Genomics. 2007 Jun; 17(6):425-30. PMID: 17502834.
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    97. Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel P. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007 Sep; 21(11):2970-9. PMID: 17470567.
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    98. Yip L, Cheung CW, Corriden R, Chen Y, Insel P, Junger WG. Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine. Shock. 2007 Mar; 27(3):242-50. PMID: 17304104.
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    99. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel P, Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J. 2007 May; 21(7):1565-74. PMID: 17272740.
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    100. Arthur DB, Taupenot L, Insel P. Nerve growth factor-stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide-stimulated catecholamine release. J Neurochem. 2007 Mar; 100(5):1257-64. PMID: 17241236.
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    101. Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel P, Yuan JX. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1202-10. PMID: 17189322.
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    102. Insel P, Patel HH. Do studies in caveolin-knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for 'lost proteins'? Br J Pharmacol. 2007 Feb; 150(3):251-4. PMID: 17179949; PMCID: PMC2013904.
    103. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel P, Junger WG. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006 Dec 15; 314(5806):1792-5. PMID: 17170310.
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    104. Rana BK, Insel P, Payne SH, Abel K, Beutler E, Ziegler MG, Schork NJ, O'Connor DT. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension. 2007 Jan; 49(1):96-106. PMID: 17159089.
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    105. Head BP, Insel P. Do caveolins regulate cells by actions outside of caveolae? Trends Cell Biol. 2007 Feb; 17(2):51-7. PMID: 17150359.
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    106. Insel P, Tang CM, Hahntow I, Michel MC. Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets. Biochim Biophys Acta. 2007 Apr; 1768(4):994-1005. PMID: 17081496; PMCID: PMC2169201.
    107. Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, Insel P. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L294-303. PMID: 16980375.
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    108. Akimova OA, Grygorczyk A, Bundey RA, Bourcier N, Gekle M, Insel P, Orlov SN. Transient activation and delayed inhibition of Na+,K+,Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. J Biol Chem. 2006 Oct 20; 281(42):31317-25. PMID: 16916802.
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    109. Bundey RA, Insel P. Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function. Mol Pharmacol. 2006 Nov; 70(5):1700-7. PMID: 16885208.
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    110. Hoekstra HE, Hirschmann RJ, Bundey RA, Insel P, Crossland JP. A single amino acid mutation contributes to adaptive beach mouse color pattern. Science. 2006 Jul 07; 313(5783):101-4. PMID: 16825572.
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    111. Arthur DB, Akassoglou K, Insel P. P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochem Biophys Res Commun. 2006 Sep 01; 347(3):678-82. PMID: 16842754.
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    112. Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel P. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 2006 Sep 08; 281(36):26391-9. PMID: 16818493.
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    113. Swaney JS, Patel HH, Yokoyama U, Head BP, Roth DM, Insel P. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. J Biol Chem. 2006 Jun 23; 281(25):17173-9. PMID: 16618703.
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    114. Arthur DB, Georgi S, Akassoglou K, Insel P. Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival. J Neurosci. 2006 Apr 05; 26(14):3798-804. PMID: 16597733.
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    115. Büscher R, Hoerning A, Patel HH, Zhang S, Arthur DB, Grasemann H, Ratjen F, Insel P. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenet Genomics. 2006 Mar; 16(3):199-205. PMID: 16495779.
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    116. Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel P, Roth DM. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H344-50. PMID: 16501018.
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    117. Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O'Connor DT, Insel P. Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension. 2006 Mar; 47(3):415-20. PMID: 16432041.
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    118. Ostrom RS, Insel P. Methods for the study of signaling molecules in membrane lipid rafts and caveolae. Methods Mol Biol. 2006; 332:181-91. PMID: 16878693.
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    119. Murray F, Insel P, Yuan JX. Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respir Physiol Neurobiol. 2006 Apr 28; 151(2-3):192-208. PMID: 16364695.
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    120. Arthur DB, Akassoglou K, Insel P. P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19138-43. PMID: 16365320; PMCID: PMC1323158.
    121. Tang CM, Insel P. Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets. Expert Opin Ther Targets. 2005 Dec; 9(6):1247-65. PMID: 16300474.
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    122. Insel P, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1131-4. PMID: 16246064.
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    123. Akimova AO, Bourcier N, Taurin S, Bundey RA, Grygorczyk K, Gekle M, Insel P, Dulin NO, Orlov SN. Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A. J Physiol. 2005 Nov 01; 568(Pt 3):789-801. PMID: 16109726; PMCID: PMC1464179.
    124. Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel P. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem. 2005 Sep 02; 280(35):31036-44. PMID: 15961389.
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    125. Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel P. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8561-6. PMID: 15939874; PMCID: PMC1150853.
    126. Insel P, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann N Y Acad Sci. 2005 Jun; 1047:166-72. PMID: 16093494.
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    127. Etzel JP, Rana BK, Wen G, Parmer RJ, Schork NJ, O'Connor DT, Insel P. Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension. 2005 Jun; 45(6):1207-13. PMID: 15920038.
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    128. Tang CM, Hoerning A, Büscher R, O'Connor DT, Ratjen F, Grasemann H, Insel P. Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis. Pharmacogenet Genomics. 2005 May; 15(5):321-7. PMID: 15864133.
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    129. King D, Etzel JP, Chopra S, Smith J, Cadman PE, Rao F, Funk SD, Rana BK, Schork NJ, Insel P, O'Connor DT. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. Clin Pharmacol Ther. 2005 May; 77(5):388-403. PMID: 15900285.
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    130. Riddle EL, Schwartzman RA, Bond M, Insel P. Multi-tasking RGS proteins in the heart: the next therapeutic target? Circ Res. 2005 Mar 04; 96(4):401-11. PMID: 15746448.
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    131. Rana BK, Insel P. Receptor databases and computational websites for ligand binding. Methods Mol Biol. 2005; 306:1-15. PMID: 15867461.
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    132. Swaney JS, Roth DM, Olson ER, Naugle JE, Meszaros JG, Insel P. Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):437-42. PMID: 15625103; PMCID: PMC544320.
    133. Siecke NW, Insel P. Clarifying the effects of adrenergic receptor polymorphisms by measuring synaptic parameters. J Am Coll Cardiol. 2004 Nov 16; 44(10):2016-8. PMID: 15542285.
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    134. Insel P, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD. Blasts from the past. J Clin Invest. 2004 Oct; 114(8):1017-33. PMID: 15489944; PMCID: PMC522273.
    135. Ostrom RS, Insel P. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol. 2004 Sep; 143(2):235-45. PMID: 15289291; PMCID: PMC1575337.
    136. Le Corre P, Parmer RJ, Kailasam MT, Kennedy BP, Skaar TP, Ho H, Leverge R, Smith DW, Ziegler MG, Insel P, Schork NJ, Flockhart DA, O'connor DT. Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther. 2004 Aug; 76(2):139-53. PMID: 15289791.
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    137. Bundey RA, Insel P. Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP? Sci STKE. 2004 Apr 28; 2004(231):pe19. PMID: 15126677.
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    138. Chen Y, Shukla A, Namiki S, Insel P, Junger WG. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J Leukoc Biol. 2004 Jul; 76(1):245-53. PMID: 15107462.
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    139. Nishihara H, Hwang M, Kizaka-Kondoh S, Eckmann L, Insel P. Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. J Biol Chem. 2004 Jun 18; 279(25):26176-83. PMID: 15078890.
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    140. Tang CM, Insel P. GPCR expression in the heart; "new" receptors in myocytes and fibroblasts. Trends Cardiovasc Med. 2004 Apr; 14(3):94-9. PMID: 15121156.
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    141. Ostrom RS, Bundey RA, Insel P. Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. J Biol Chem. 2004 May 07; 279(19):19846-53. PMID: 15007069.
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    142. Zhang L, Insel P. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem. 2004 May 14; 279(20):20858-65. PMID: 14996839.
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    143. Kirstein SL, Insel P. Autonomic nervous system pharmacogenomics: a progress report. Pharmacol Rev. 2004 Mar; 56(1):31-52. PMID: 15001662.
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    144. Liu X, Ostrom RS, Insel P. cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. Am J Physiol Cell Physiol. 2004 May; 286(5):C1089-99. PMID: 15075208.
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    145. Koopmans RP, Insel P, Michel MC. Pharmacogenetics of hypertension treatment: a structured review. Pharmacogenetics. 2003 Dec; 13(12):705-13. PMID: 14646689.
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    146. Bundey RA, Insel P. Quantification of adenylyl cyclase messenger RNA by real-time polymerase chain reaction. Anal Biochem. 2003 Aug 15; 319(2):318-22. PMID: 12871728.
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    147. Brindikova TA, Bourcier N, Torres B, Pchejetski D, Gekle M, Maximov GV, Montminy V, Insel P, Orlov SN, Isenring P. Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1445-53. PMID: 12917108.
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    148. Insel P, Kirstein SL. Naturally occurring variants in catecholamine receptor genes. Auton Autacoid Pharmacol. 2003 Aug; 23(4):228-30. PMID: 15132132.
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    149. Nishihara H, Kizaka-Kondoh S, Insel P, Eckmann L. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8921-6. PMID: 12837940; PMCID: PMC166414.
    150. Insel P, Ostrom RS. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cell Mol Neurobiol. 2003 Jun; 23(3):305-14. PMID: 12825829.
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    151. Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel P, Brunton LL, Meszaros JG. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J Biol Chem. 2003 Jul 04; 278(27):24461-8. PMID: 12711600.
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    152. Insel P. Location, location, location. Trends Endocrinol Metab. 2003 Apr; 14(3):100-2. PMID: 12670730.
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    153. Patel HH, Fryer RM, Gross ER, Bundey RA, Hsu AK, Isbell M, Eusebi LO, Jensen RV, Gullans SR, Insel P, Nithipatikom K, Gross GJ. 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. Circ Res. 2003 Apr 04; 92(6):676-82. PMID: 12623876.
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    154. Bruck H, Leineweber K, Büscher R, Ulrich A, Radke J, Insel P, Brodde OE. The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo. Pharmacogenetics. 2003 Feb; 13(2):59-66. PMID: 12563174.
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    155. Michel MC, Insel P. Receptor gene polymorphisms: lessons on functional relevance from the beta 1-adrenoceptor. Br J Pharmacol. 2003 Jan; 138(2):279-82. PMID: 12540516; PMCID: PMC1573661.
    156. Loomis WH, Namiki S, Ostrom RS, Insel P, Junger WG. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem. 2003 Feb 14; 278(7):4590-6. PMID: 12464620.
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    157. Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel P. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Mol Pharmacol. 2002 Nov; 62(5):983-92. PMID: 12391260.
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    158. Rana BK, Insel P. G-protein-coupled receptor websites. Trends Pharmacol Sci. 2002 Nov; 23(11):535-6. PMID: 12413809.
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    159. Büscher R, Eilmes KJ, Grasemann H, Torres B, Knauer N, Sroka K, Insel P, Ratjen F. beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics. 2002 Jul; 12(5):347-53. PMID: 12142724.
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    160. Michel MC, Jasper JR, Insel P. Adrenoceptors: a convergence of thinking. Mol Interv. 2002 Jul; 2(4):198-200. PMID: 14993387.
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    161. Torres B, Zambon AC, Insel P. P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D(1) cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation. J Biol Chem. 2002 Mar 08; 277(10):7761-5. PMID: 11788591.
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    162. Insel P, Ostrom RS, Zambon AC, Hughes RJ, Balboa MA, Shehnaz D, Gregorian C, Torres B, Firestein BL, Xing M, Post SR. P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides. Clin Exp Pharmacol Physiol. 2001 Apr; 28(4):351-4. PMID: 11339212.
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