Paul Insel

Title(s)Recall Faculty, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    M.D.University of Michigan, Ann Arbor

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Nanobody inhibitors of proton-sensing G protein-coupled receptors
    NIH R03TR003639Apr 1, 2021 - Mar 31, 2022
    Role: Co-Principal Investigator
    Caveolin-3 and cardiac fibrosis
    NIH R21AG052914Apr 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Aging and G-protein-regulated MMP14
    NIH R21AG053568Sep 30, 2016 - Apr 30, 2019
    Role: Principal Investigator
    GPCRs: novel targets in cancer-associated fibroblasts
    NIH R21CA189477Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    2011 Molecular Pharmacology GRC and GRS
    NIH R13DA030871Jan 7, 2011 - Dec 31, 2011
    Role: Principal Investigator
    2009 Molecular Pharmacology Gordon Research Conference
    NIH R13DA026640Mar 1, 2009 - Feb 27, 2010
    Role: Principal Investigator
    GPCRs: Evolving Concepts and Drug Discovery
    NIH R13DA017912Mar 1, 2004 - Dec 31, 2004
    Role: Principal Investigator
    Adrenergic and Purinergic Regulation of Target Cells
    NIH R01GM066232Jul 1, 2002 - Aug 31, 2012
    Role: Principal Investigator
    Beta-Adrenergic Receptors of S49 Lymphoma Cells
    NIH R01GM061774Mar 1, 2002 - Feb 28, 2007
    Role: Principal Investigator
    Autonomic Pharmacodynamic Pharmacogenomics
    NIH U01HL069758Sep 13, 2001 - Aug 31, 2005
    Role: Co-Investigator
    Discovery and Development of Therapeutic Genes for CHF
    NIH P01HL066941Sep 29, 2000 - Jun 30, 2020
    Role: Co-Investigator
    CARDIOVASCULAR CELL GENE TRANSFER OF ADENYLYL CYCLASE
    NIH R01HL063885Sep 1, 2000 - Aug 31, 2004
    Role: Principal Investigator
    Sympathetic Neuroeffector Junctions &Blood Pressure
    NIH P01HL058120Jun 1, 1999 - May 31, 2012
    Role: Co-Investigator
    MOLECULAR PHYSIOLOGY OF HEART FAILURE
    NIH P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Co-Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    BETA-ADRENERGIC RECEPTORS IN S49 LYMPHOMA CELLS
    NIH R01GM040781Aug 1, 1988 - Nov 30, 1998
    Role: Principal Investigator
    RENAL ADRENERGIC RECEPTORS AND HYPERTENSION
    NIH R01HL035847Feb 1, 1986 - Jan 31, 1991
    Role: Principal Investigator
    CELLULAR ACTIONS OF CATECHOLAMINE RECEPTORS
    NIH R01GM031987Jan 1, 1983 - Jul 31, 1999
    Role: Principal Investigator
    Medical Scientist Training Program
    NIH T32GM007198Jul 1, 1975 - Jun 30, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Introduction to the Theme "Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment". Annu Rev Pharmacol Toxicol. 2024 Jan 23; 64:27-31. Meyer UA, Amara SG, Blaschke TF, Insel PA. PMID: 37816308.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Ramipril for the Treatment of COVID-19: RAMIC, a Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Adv Ther. 2023 11; 40(11):4805-4816. Huang DQ, Ajmera V, Tomaszewski C, LaFree A, Bettencourt R, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Insel PA, Leachman S, Jung J, Collier S, Richards L, Woods K, Amangurbanova M, Bhatt A, Zhang X, Penciu OM, Zarich S, Retta T, Harkins MS, Teixeira JP, Chinnock B, Utay NS, Lake JE, Loomba R. PMID: 37615850; PMCID: PMC10709987.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts. Cell Rep. 2023 05 30; 42(5):112453. Di Nardo A, Chang YL, Alimohammadi S, Masuda-Kuroki K, Wang Z, Sriram K, Insel PA. PMID: 37120813; PMCID: PMC10290424.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. BJP recommendations for publishing research on tobacco smoke and environmental tobacco smoke exposure. Br J Pharmacol. 2023 06; 180(12):1537-1541. Panettieri RA, Stanford SC, Alexander S, Cirino G, George CH, Insel PA, Kendall D, Ji Y, Patel HH, Sobey CG, Stefanska B, Stephens G, Teixeira M, Vergnolle N, Ferdinandy P, Ahluwalia A. PMID: 37092682.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    5. Considering and reporting sex as an experimental variable II: An update on progress in the British Journal of Pharmacology. Br J Pharmacol. 2023 05; 180(9):1191-1196. Stanford SC, Alexander S, Cirino G, George CH, Insel PA, Kendall D, Ji Y, Panettieri RA, Patel HH, Sobey CG, Stefanska B, Stephens G, Teixeira M, Vergnolle N, Ferdinandy P, Ahluwalia A. PMID: 36876456.
      View in: PubMed   Mentions:    Fields:    
    6. GPCR Signaling Measurement and Drug Profiling with an Automated Live-Cell Microscopy System. ACS Sens. 2023 01 27; 8(1):19-27. Greenwald E, Posner C, Bharath A, Lyons A, Salmerón C, Sriram K, Wiley SZ, Insel PA, Zhang J. PMID: 36602887; PMCID: PMC9994309.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Guidance for the use and reporting of anaesthetic agents in BJP manuscripts involving work with animals. Br J Pharmacol. 2023 02; 180(3):255-263. Ingrande J, Patel HH, Kendall D, Stefanska B, Alexander S, Bakhle M, Cirino G, Docherty JR, George CH, Insel PA, Ji Y, King BF, Lilley E, Panettieri RA, Ramage AG, Sobey CG, Stanford SC, Stephens G, Teixeira M, Vergnolle N, Ahluwalia A. PMID: 36529953.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Introduction to the Theme "Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care". Annu Rev Pharmacol Toxicol. 2023 01 20; 63:15-18. Blaschke TF, Insel PA, Amara SG, Meyer UA. PMID: 36270297.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    9. Planning experiments: Updated guidance on experimental design and analysis and their reporting III. Br J Pharmacol. 2022 08; 179(15):3907-3913. Curtis MJ, Alexander SPH, Cirino G, George CH, Kendall DA, Insel PA, Izzo AA, Ji Y, Panettieri RA, Patel HH, Sobey CG, Stanford SC, Stanley P, Stefanska B, Stephens GJ, Teixeira MM, Vergnolle N, Ahluwalia A. PMID: 35673806.
      View in: PubMed   Mentions: 17     Fields:    
    10. PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells. Front Pharmacol. 2022; 13:833832. Chinn AM, Salmerón C, Lee J, Sriram K, Raz E, Insel PA. PMID: 35387344; PMCID: PMC8977838.
      View in: PubMed   Mentions: 2  
    11. Introduction to the Theme "New Insights, Strategies, and Therapeutics for Common Diseases". Annu Rev Pharmacol Toxicol. 2022 01 06; 62:19-24. Insel PA, Blaschke TF, Amara SG, Meyer UA. PMID: 34606327.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Inhaled β2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome? Pharmacol Rev. 2021 10; 73(4):488-526. Sriram K, Insel MB, Insel PA. PMID: 34795026.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). Br J Pharmacol. 2021 09; 178(18):3605-3610. George CH, Alexander SPH, Cirino G, Insel PA, Izzo AA, Ji Y, Kendall DA, Panettieri RA, Patel HH, Sobey CG, Stanford SC, Stefanska B, Stephens G, Teixeira M, Ahluwalia A. PMID: 34328225.
      View in: PubMed   Mentions: 1     Fields:    
    14. RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19. Contemp Clin Trials. 2021 04; 103:106330. Ajmera V, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Sriram K, Insel PA, Collier S, Richards L, Loomba R. PMID: 33631357; PMCID: PMC7899027.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    15. Introduction to the Theme "Old and New Toxicology: Interfaces with Pharmacology". Annu Rev Pharmacol Toxicol. 2021 01 06; 61:1-7. Costa M, Blaschke TF, Amara SG, Meyer UA, Insel PA. PMID: 33411582.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Detection of GPCR mRNA Expression in Primary Cells Via qPCR, Microarrays, and RNA-Sequencing. Methods Mol Biol. 2021; 2268:21-42. Sriram K, Salmerón C, Di Nardo A, Insel PA. PMID: 34085259.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges. Proc Natl Acad Sci U S A. 2020 11 24; 117(47):29274-29282. Sriram K, Loomba R, Insel PA. PMID: 33203679; PMCID: PMC7703541.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    18. Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets. Physiol Rev. 2021 04 01; 101(2):545-567. Sriram K, Insel PA. PMID: 33124941; PMCID: PMC8238137.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    19. RAAS Inhibitors and Risk of Covid-19. N Engl J Med. 2020 Nov 12; 383(20):1991-1992. Sriram K, Loomba R, Insel PA. PMID: 33108103.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    20. Proteinase-activated receptor 1: A target for repurposing in the treatment of COVID-19? Br J Pharmacol. 2020 11; 177(21):4971-4974. Sriram K, Insel PA. PMID: 32639031; PMCID: PMC7361899.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    21. ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020. Br J Pharmacol. 2020 08; 177(16):3611-3616. Lilley E, Stanford SC, Kendall DE, Alexander SPH, Cirino G, Docherty JR, George CH, Insel PA, Izzo AA, Ji Y, Panettieri RA, Sobey CG, Stefanska B, Stephens G, Teixeira M, Ahluwalia A. PMID: 32662875; PMCID: PMC7393193.
      View in: PubMed   Mentions: 148     Fields:    Translation:Animals
    22. Assessment of ACE inhibitors/angiotensin receptor blockers in COVID-19 patients. Am J Physiol Lung Cell Mol Physiol. 2020 07 01; 319(1):L37-L38. Sriram K, Insel PA. PMID: 33496632; PMCID: PMC7524453.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Cyclic AMP in dendritic cells: A novel potential target for disease-modifying agents in asthma and other allergic disorders. Br J Pharmacol. 2020 08; 177(15):3363-3377. Chinn AM, Insel PA. PMID: 32372523; PMCID: PMC7348084.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance. Br J Pharmacol. 2020 11; 177(21):4825-4844. Sriram K, Insel PA. PMID: 32333398; PMCID: PMC7572451.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    25. Transcriptomic analysis of pulmonary artery smooth muscle cells identifies new potential therapeutic targets for idiopathic pulmonary arterial hypertension. Br J Pharmacol. 2020 08; 177(15):3505-3518. Gorr MW, Sriram K, Muthusamy A, Insel PA. PMID: 32337710; PMCID: PMC7348089.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence. Clin Pharmacol Ther. 2020 08; 108(2):236-241. Sriram K, Insel PA. PMID: 32320478; PMCID: PMC7264499.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsPHPublic Health
    27. A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research. Br J Pharmacol. 2020 05; 177(10):2169-2178. Izzo AA, Teixeira M, Alexander SPH, Cirino G, Docherty JR, George CH, Insel PA, Ji Y, Kendall DA, Panattieri RA, Sobey CG, Stanford SC, Stefanska B, Stephens G, Ahluwalia A. PMID: 32298474; PMCID: PMC7174877.
      View in: PubMed   Mentions: 25     Fields:    
    28. GPCRs in pancreatic adenocarcinoma: Contributors to tumour biology and novel therapeutic targets. Br J Pharmacol. 2020 06; 177(11):2434-2455. Sriram K, Salmerón C, Wiley SZ, Insel PA. PMID: 32060895; PMCID: PMC7205828.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    29. Proton-sensing G protein-coupled receptors: detectors of tumor acidosis and candidate drug targets. Future Med Chem. 2020 03; 12(6):523-532. Insel PA, Sriram K, Salmerón C, Wiley SZ. PMID: 32116003; PMCID: PMC7607387.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    30. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 2020 02 04; 9. Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E. PMID: 32014112; PMCID: PMC7000221.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. Introduction to the Theme "Ion Channels and Neuropharmacology: From the Past to the Future". Annu Rev Pharmacol Toxicol. 2020 01 06; 60:1-6. Dolphin AC, Insel PA, Blaschke TF, Meyer UA. PMID: 31914892.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    32. Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxia. Physiol Rep. 2020 01; 8(2):e14344. Gorr MW, Sriram K, Chinn AM, Muthusamy A, Insel PA. PMID: 31960631; PMCID: PMC6971333.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    33. The BJP expects authors to share data. Br J Pharmacol. 2019 12; 176(24):4595-4598. George CH, Alexander SPH, Cirino G, Docherty JR, Hoyer D, Insel PA, Izzo AA, Ji Y, Panettieri RA, Sobey CG, Stanford SC, Stefanska B, Stephens G, Teixeira M, Ahluwalia A. PMID: 31950490; PMCID: PMC6965667.
      View in: PubMed   Mentions: 1     Fields:    
    34. GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors. PLoS Biol. 2019 11; 17(11):e3000434. Sriram K, Moyung K, Corriden R, Carter H, Insel PA. PMID: 31765370; PMCID: PMC6901242.
      View in: PubMed   Mentions: 34     Fields:    
    35. Detection and Quantification of GPCR mRNA: An Assessment and Implications of Data from High-Content Methods. ACS Omega. 2019 Oct 15; 4(16):17048-17059. Sriram K, Wiley SZ, Moyung K, Gorr MW, Salmerón C, Marucut J, French RP, Lowy AM, Insel PA. PMID: 31646252; PMCID: PMC6796235.
      View in: PubMed   Mentions: 19  
    36. GPCRomics: An Approach to Discover GPCR Drug Targets. Trends Pharmacol Sci. 2019 06; 40(6):378-387. Insel PA, Sriram K, Gorr MW, Wiley SZ, Michkov A, Salmerón C, Chinn AM. PMID: 31078319; PMCID: PMC6604616.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    37. Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling. Am J Physiol Lung Cell Mol Physiol. 2019 05 01; 316(5):L810-L821. Mukherjee S, Sheng W, Michkov A, Sriarm K, Sun R, Dvorkin-Gheva A, Insel PA, Janssen LJ. PMID: 30758990; PMCID: PMC6589580.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    38. GPR68: An Emerging Drug Target in Cancer. Int J Mol Sci. 2019 Jan 28; 20(3). Wiley SZ, Sriram K, Salmerón C, Insel PA. PMID: 30696114; PMCID: PMC6386835.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    39. Introduction to the Theme "New Therapeutic Targets". Annu Rev Pharmacol Toxicol. 2019 01 06; 59:15-20. Insel PA, Amara SG, Blaschke TF, Meyer UA. PMID: 30625286.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    40. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Front Pharmacol. 2018; 9:431. Insel PA, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy AM, Murray F. PMID: 29872392; PMCID: PMC5972277.
      View in: PubMed   Mentions: 57  
    41. Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. Br J Pharmacol. 2018 04; 175(7):987-993. Curtis MJ, Alexander S, Cirino G, Docherty JR, George CH, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Stanford SC, Teixeira MM, Wonnacott S, Ahluwalia A. PMID: 29520785; PMCID: PMC5843711.
      View in: PubMed   Mentions: 636     Fields:    
    42. Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology. Br J Pharmacol. 2018 02; 175(3):407-411. Alexander SPH, Roberts RE, Broughton BRS, Sobey CG, George CH, Stanford SC, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Mangum J, Wonnacott S, Ahluwalia A. PMID: 29350411; PMCID: PMC5773976.
      View in: PubMed   Mentions: 218     Fields:    Translation:Humans
    43. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? Mol Pharmacol. 2018 04; 93(4):251-258. Sriram K, Insel PA. PMID: 29298813; PMCID: PMC5820538.
      View in: PubMed   Mentions: 426     Fields:    Translation:HumansAnimals
    44. GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J. 2018 03; 32(3):1170-1183. Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA. PMID: 29092903; PMCID: PMC5892729.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    45. Introduction to the Theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development". Annu Rev Pharmacol Toxicol. 2018 01 06; 58:33-36. Insel PA, Amara SG, Blaschke TF, Meyer UA. PMID: 29058990.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts. Br J Pharmacol. 2017 09; 174(17):2801-2804. George CH, Stanford SC, Alexander S, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Wonnacott S, Ahluwalia A. PMID: 28801996; PMCID: PMC5554317.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    47. Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C459-C477. Busija AR, Patel HH, Insel PA. PMID: 28122734; PMCID: PMC5407024.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    48. Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology". Annu Rev Pharmacol Toxicol. 2017 01 06; 57:13-17. Insel PA, Amara SG, Blaschke TF, Meyer UA. PMID: 27732830.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    49. The Molecular Pharmacology of G Protein Signaling Then and Now: A Tribute to Alfred G. Gilman. Mol Pharmacol. 2016 May; 89(5):585-92. Sunahara RK, Insel PA. PMID: 26984025.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    50. The Gq signalling pathway inhibits brown and beige adipose tissue. Nat Commun. 2016 Mar 09; 7:10895. Klepac K, Kilic A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A. PMID: 26955961; PMCID: PMC4786868.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    51. Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation. FASEB J. 2016 Apr; 30(4):1464-79. Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D. PMID: 26675706; PMCID: PMC4799510.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    52. Introduction to the Theme "Cancer Pharmacology". Annu Rev Pharmacol Toxicol. 2016; 56:19-22. Insel PA, Amara SG, Blaschke TF, Meyer UA. PMID: 26551200.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12681-6. Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS. PMID: 26417071; PMCID: PMC4611605.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    54. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. PMID: 26203188; PMCID: PMC4571978.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    55. Experimental design and analysis and their reporting: new guidance for publication in BJP. Br J Pharmacol. 2015 Jul; 172(14):3461-71. Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SP, Giembycz MA, Gilchrist A, Hoyer D, Insel PA, Izzo AA, Lawrence AJ, MacEwan DJ, Moon LD, Wonnacott S, Weston AH, McGrath JC. PMID: 26114403; PMCID: PMC4507152.
      View in: PubMed   Mentions: 742     Fields:    Translation:HumansAnimals
    56. The First 50 Years of Molecular Pharmacology. Mol Pharmacol. 2015 Jul; 88(1):139-40. Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. PMID: 25943115.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    57. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor. Ann Clin Transl Neurol. 2015 Jun; 2(6):595-608. Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel PA, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL. PMID: 26125036; PMCID: PMC4479521.
      View in: PubMed   Mentions: 77     Fields:    
    58. Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation. J Biol Chem. 2015 Apr 17; 290(16):9941-7. Overland AC, Insel PA. PMID: 25759388; PMCID: PMC4400366.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    59. G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets. Mol Pharmacol. 2015 Jul; 88(1):181-7. Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R. PMID: 25737495; PMCID: PMC4468643.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    60. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. PMID: 25605931; PMCID: PMC4321256.
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    61. Introduction to the theme "Precision medicine and prediction in pharmacology". Annu Rev Pharmacol Toxicol. 2015; 55:11-4. Insel PA, Amara SG, Blaschke TF. PMID: 25562643.
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    62. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. J Biol Chem. 2014 Oct 17; 289(42):29148-57. Brown LM, Rogers KE, Aroonsakool N, McCammon JA, Insel PA. PMID: 25183009; PMCID: PMC4200268.
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    63. AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. Am J Physiol Cell Physiol. 2014 Oct 01; 307(7):C581. Foufelle F, Lotersztajn S, Insel PA, Chevet E. PMID: 24990648.
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    64. Regulation of intracellular signaling and function by caveolin. FASEB J. 2014 Sep; 28(9):3823-31. Fridolfsson HN, Roth DM, Insel PA, Patel HH. PMID: 24858278; PMCID: PMC4139902.
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    65. Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition. J Biol Chem. 2014 Mar 21; 289(12):8217-30. Brown LM, Rogers KE, McCammon JA, Insel PA. PMID: 24497631; PMCID: PMC3961650.
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    66. Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C779-88. Lu D, Insel PA. PMID: 24352335; PMCID: PMC4010809.
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    67. I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?". Am J Physiol Cell Physiol. 2014 Jan 01; 306(1):C1-2. Fuller CM, Insel PA. PMID: 24225885.
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    68. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol. 2013 Dec; 84(6):787-93. Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA. PMID: 24085841; PMCID: PMC3834140.
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    69. A theme series on physical biology in cancer in AJP-Cell. Am J Physiol Cell Physiol. 2014 Jan 15; 306(2):C77. McCarty OJ, King MR, Insel PA. PMID: 24067917; PMCID: PMC3919984.
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    70. Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochim Biophys Acta. 2014 Feb; 1838(2):532-45. Head BP, Patel HH, Insel PA. PMID: 23899502; PMCID: PMC3867519.
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    71. AJP-Cell Physiology begins a Theme series on Evolution and Cell Physiology. Am J Physiol Cell Physiol. 2013 Oct 01; 305(7):C681. Torday JS, Insel PA. PMID: 23824845.
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    72. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training. Acad Med. 2013 Jun; 88(6):745-7. Goldberg C, Insel PA. PMID: 23708597; PMCID: PMC3882192.
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    73. Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts. J Biol Chem. 2013 Jun 28; 288(26):19040-9. Lu D, Insel PA. PMID: 23677997; PMCID: PMC3696677.
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    74. Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma. Expert Opin Ther Targets. 2013 Aug; 17(8):937-49. Murray F, Insel PA. PMID: 23647244.
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    75. AJP-Cell begins a theme series on tissue fibrosis. Am J Physiol Cell Physiol. 2013 Feb 01; 304(3):C215. Lotersztajn S, Insel PA. PMID: 23255579.
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    76. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 2012 Nov 20; 51(46):9323-32. Guo Y, Wilderman A, Zhang L, Taylor SS, Insel PA. PMID: 23110364; PMCID: PMC3503394.
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    77. Special issue on cell and molecular biology of purinergic signalling: an introduction. Purinergic Signal. 2012 Sep; 8(3):341. Burnstock G, Insel PA, Di Virgilio F. PMID: 22476941; PMCID: PMC3360090.
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    78. Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. FASEB J. 2012 Nov; 26(11):4540-7. Snead AN, Insel PA. PMID: 22859370; PMCID: PMC3475245.
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    79. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. PMID: 22859372; PMCID: PMC4050367.
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    80. Can you blame cold feet on Epac (and Rap1A)? Focus on "cyclic AMP-Rap1A signaling activates RhoA to induce α(2C)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells". Am J Physiol Cell Physiol. 2012 Sep 01; 303(5):C488-9. Michel MC, Insel PA. PMID: 22814395.
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    81. cAMP and Epac in the regulation of tissue fibrosis. Br J Pharmacol. 2012 May; 166(2):447-56. Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N. PMID: 22233238; PMCID: PMC3417479.
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    82. New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors. Purinergic Signal. 2012 Sep; 8(3):587-98. Corriden R, Insel PA. PMID: 22528684; PMCID: PMC3360098.
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    83. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. PMID: 22493239; PMCID: PMC3356610.
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    84. ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors. FASEB J. 2012 Jun; 26(6):2580-91. Lu D, Soleymani S, Madakshire R, Insel PA. PMID: 22415310; PMCID: PMC3360157.
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    85. Discovery- and target-based protein quantification using iTRAQ and pulsed Q collision induced dissociation (PQD). J Proteomics. 2012 Apr 18; 75(8):2480-7. Wu WW, Wang G, Insel PA, Hsiao CT, Zou S, Martin B, Maudsley S, Shen RF. PMID: 22397766; PMCID: PMC3321122.
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    86. Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest. 2012 Mar; 122(3):963-73. Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. PMID: 22326954; PMCID: PMC3287220.
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    87. Receptor databases and computational websites for ligand binding. Methods Mol Biol. 2012; 897:1-13. Rana BK, Bourne PE, Insel PA. PMID: 22674158.
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    88. β(2)-Adrenergic receptor polymorphisms and signaling: Do variants influence the "memory" of receptor activation? Sci Signal. 2011 Aug 09; 4(185):pe37. Insel PA. PMID: 21868355.
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    89. Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. J Biol Chem. 2011 Sep 23; 286(38):33260-7. Zambon AC, Wilderman A, Ho A, Insel PA. PMID: 21808067; PMCID: PMC3190928.
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    90. Genetic variation in phosphodiesterase (PDE) 7B in chronic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDEs in human disease. J Hum Genet. 2011 Sep; 56(9):676-81. Peiró AM, Tang CM, Murray F, Zhang L, Brown LM, Chou D, Rassenti L, Kipps TJ, Kipps TA, Insel PA. PMID: 21796143; PMCID: PMC3833258.
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    91. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem. 2011 Sep 23; 286(38):33310-21. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. PMID: 21799010; PMCID: PMC3190943.
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    92. Editor's Note: AJP-Cell and AJP-Renal article series to honor the work of Dale Benos. Am J Physiol Cell Physiol. 2011 Oct; 301(4):C749. Kleyman TR, Insel PA, Frank M. PMID: 21795524.
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    93. Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD). J Am Soc Mass Spectrom. 2011 Oct; 22(10):1753-62. Wu WW, Wang G, Insel PA, Hsiao CT, Zou S, Maudsley S, Martin B, Shen RF. PMID: 21952889; PMCID: PMC3183836.
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    94. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J. 2011 Oct; 25(10):3356-65. Creighton J, Jian M, Sayner S, Alexeyev M, Insel PA. PMID: 21680893; PMCID: PMC3177581.
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    95. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011 May 31; 57(22):2273-83. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. PMID: 21616289; PMCID: PMC3236642.
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    96. Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger. Acta Physiol (Oxf). 2012 Feb; 204(2):277-87. Insel PA, Zhang L, Murray F, Yokouchi H, Zambon AC. PMID: 21385327; PMCID: PMC3125423.
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    97. P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R510-8. Rieg T, Gerasimova M, Boyer JL, Insel PA, Vallon V. PMID: 21613580; PMCID: PMC3154711.
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    98. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cell Signal. 2011 Oct; 23(10):1611-6. Zhang L, Yun H, Murray F, Lu R, Wang L, Hook V, Insel PA. PMID: 21620962; PMCID: PMC3148345.
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    99. Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization. J Biol Chem. 2011 Apr 29; 286(17):14830-41. Fuhs SR, Insel PA. PMID: 21362625; PMCID: PMC3083237.
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    100. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 2011 Mar 24; 471(7339):499-503. Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, Craig D, Kelsoe JR, Gershon ES, Leal SM, Dell Aquila M, Morris DW, Gill M, Corvin A, Insel PA, McClellan J, King MC, Karayiorgou M, Levy DL, DeLisi LE, Sebat J. PMID: 21346763; PMCID: PMC3351382.
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    101. Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia. Int J Cancer. 2011 Sep 01; 129(5):1162-9. Zhang L, Murray F, Rassenti LZ, Pu M, Kelly C, Kanter JR, Greaves A, Messer K, Kipps TJ, Insel PA. PMID: 21120911; PMCID: PMC3111850.
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    102. AJP-Cell Physiology initiates publication of the Hans H. Ussing Lecture. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1221. Levi M, Insel PA. PMID: 20881237.
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    103. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol. 2010 Dec; 21(12):2059-68. Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V. PMID: 20864687; PMCID: PMC3014019.
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    104. Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol. 2010 Nov; 21(11):1903-11. Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O. PMID: 20813869; PMCID: PMC3014005.
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    105. Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood. 2010 Nov 04; 116(18):3475-84. Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG. PMID: 20660288; PMCID: PMC2981474.
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    106. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 03; 285(36):27632-40. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. PMID: 20581396; PMCID: PMC2934631.
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    107. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. PMID: 20479237; PMCID: PMC2890829.
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    108. Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors. J Mol Cell Cardiol. 2010 Sep; 49(3):362-9. Braun OO, Lu D, Aroonsakool N, Insel PA. PMID: 20471392; PMCID: PMC2917486.
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    109. Historical perspectives in cell physiology: looking back to help the discipline move forward. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1279. Insel PA. PMID: 20237145.
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    110. Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G protein (G(s)) in intestinal epithelial cell differentiation. J Biol Chem. 2010 Apr 23; 285(17):12504-11. Choi LJ, Jenikova G, Hanson E, Spehlmann ME, Boehling NS, Kirstein SL, Bundey RA, Smith JR, Insel PA, Eckmann L. PMID: 20157112; PMCID: PMC2857080.
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    111. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone. FASEB J. 2010 Jun; 24(6):2056-65. Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. PMID: 20097874; PMCID: PMC2874475.
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    112. American Journal of Physiology-Cell Physiology initiates a series of articles around a theme: autophagy is the first theme. Am J Physiol Cell Physiol. 2010 Apr; 298(4):C775. Lotersztajn S, Insel PA. PMID: 20071687.
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    113. Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal. 2010 Jan 12; 3(104):re1. Corriden R, Insel PA. PMID: 20068232; PMCID: PMC3085344.
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    114. The best "model system" for human (coronary arteries) is human. J Am Coll Cardiol. 2009 Sep 22; 54(13):1146-8. Braun OO, Insel PA. PMID: 19761934.
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    115. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Kidney Int. 2009 Nov; 76(10):1070-80. Fung MM, Rana BK, Tang CM, Shiina T, Nievergelt CM, Rao F, Salem RM, Waalen J, Ziegler MG, Insel PA, O'Connor DT. PMID: 19675531; PMCID: PMC2803094.
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    116. Lipid rafts and caveolae and their role in compartmentation of redox signaling. Antioxid Redox Signal. 2009 Jun; 11(6):1357-72. Patel HH, Insel PA. PMID: 19061440; PMCID: PMC2757136.
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    117. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J. 2009 Jun; 23(6):1685-93. Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel PA, Junger WG. PMID: 19211924; PMCID: PMC2718802.
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    118. Membrane rafts and caveolae in cardiovascular signaling. Curr Opin Nephrol Hypertens. 2009 Jan; 18(1):50-6. Insel PA, Patel HH. PMID: 19077689; PMCID: PMC2757134.
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    119. P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G424-32. Dong X, Smoll EJ, Ko KH, Lee J, Chow JY, Kim HD, Insel PA, Dong H. PMID: 19074643; PMCID: PMC2643905.
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    120. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19532-7. Zhang L, Murray F, Zahno A, Kanter JR, Chou D, Suda R, Fenlon M, Rassenti L, Cottam H, Kipps TJ, Insel PA. PMID: 19033455; PMCID: PMC2614795.
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    121. Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem. 2008 Dec 26; 283(52):36599-607. Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JD. PMID: 18981175; PMCID: PMC2605978.
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    122. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation. 2008 Nov 04; 118(19):1979-88. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. PMID: 18936328; PMCID: PMC2676165.
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    123. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem. 2008 Oct 17; 283(42):28480-6. Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. PMID: 18713747; PMCID: PMC2568933.
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    124. Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp Lung Res. 2008 May; 34(4):195-208. Schach C, Firth AL, Xu M, Remillard CV, Patel HH, Insel PA, Yuan JX. PMID: 18432456; PMCID: PMC5524512.
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    125. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6386-91. Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. PMID: 18434542; PMCID: PMC2359804.
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    126. Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F638-44. Rieg T, Pothula K, Schroth J, Satriano J, Osswald H, Schnermann J, Insel PA, Bundey RA, Vallon V. PMID: 18199602.
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    127. Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol. 2008; 48:359-91. Patel HH, Murray F, Insel PA. PMID: 17914930; PMCID: PMC3083858.
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    128. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J Biol Chem. 2008 Feb 15; 283(7):4304-13. Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA. PMID: 18048352; PMCID: PMC3882191.
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    129. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol. 2008 Jan; 44(1):123-30. Horikawa YT, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, Roth DM. PMID: 18054955; PMCID: PMC2701396.
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    130. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 2008 Mar; 22(3):828-40. Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, Patel PM. PMID: 17905724.
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    131. Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3216-20. Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel PA, Roth DM. PMID: 17873016.
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    132. British Pharmacology Society 2nd Focused meeting on Cell Signalling: GPCRs have sunny days in springtime Leicester. Expert Opin Ther Targets. 2007 Sep; 11(9):1251-3. Insel PA. PMID: 17845149.
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    133. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1420-5. Corriden R, Insel PA, Junger WG. PMID: 17699635.
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    134. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J. 2007 Nov; 21(13):3717-26. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. PMID: 17575258.
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    135. Beta-2-adrenergic receptor polymorphisms in cystic fibrosis. Pharmacogenet Genomics. 2007 Jun; 17(6):425-30. Steagall WK, Barrow BJ, Glasgow CG, Mendoza JW, Ehrmantraut M, Lin JP, Insel PA, Moss J. PMID: 17502834; PMCID: PMC3021988.
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    136. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007 Sep; 21(11):2970-9. Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. PMID: 17470567.
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    137. Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine. Shock. 2007 Mar; 27(3):242-50. Yip L, Cheung CW, Corriden R, Chen Y, Insel PA, Junger WG. PMID: 17304104.
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    138. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J. 2007 May; 21(7):1565-74. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth DM. PMID: 17272740.
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    139. Nerve growth factor-stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide-stimulated catecholamine release. J Neurochem. 2007 Mar; 100(5):1257-64. Arthur DB, Taupenot L, Insel PA. PMID: 17241236.
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    140. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1202-10. Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JX. PMID: 17189322.
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    141. Do studies in caveolin-knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for 'lost proteins'? Br J Pharmacol. 2007 Feb; 150(3):251-4. Insel PA, Patel HH. PMID: 17179949; PMCID: PMC2013904.
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    142. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006 Dec 15; 314(5806):1792-5. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. PMID: 17170310.
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    143. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension. 2007 Jan; 49(1):96-106. Rana BK, Insel PA, Payne SH, Abel K, Beutler E, Ziegler MG, Schork NJ, O'Connor DT. PMID: 17159089.
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    144. Do caveolins regulate cells by actions outside of caveolae? Trends Cell Biol. 2007 Feb; 17(2):51-7. Head BP, Insel PA. PMID: 17150359.
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    145. Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets. Biochim Biophys Acta. 2007 Apr; 1768(4):994-1005. Insel PA, Tang CM, Hahntow I, Michel MC. PMID: 17081496; PMCID: PMC2169201.
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    146. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L294-303. Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, Insel PA. PMID: 16980375.
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    147. Transient activation and delayed inhibition of Na+,K+,Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. J Biol Chem. 2006 Oct 20; 281(42):31317-25. Akimova OA, Grygorczyk A, Bundey RA, Bourcier N, Gekle M, Insel PA, Orlov SN. PMID: 16916802.
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    148. Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function. Mol Pharmacol. 2006 Nov; 70(5):1700-7. Bundey RA, Insel PA. PMID: 16885208.
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    149. A single amino acid mutation contributes to adaptive beach mouse color pattern. Science. 2006 Jul 07; 313(5783):101-4. Hoekstra HE, Hirschmann RJ, Bundey RA, Insel PA, Crossland JP. PMID: 16825572.
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    150. P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochem Biophys Res Commun. 2006 Sep 01; 347(3):678-82. Arthur DB, Akassoglou K, Insel PA. PMID: 16842754.
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    151. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 2006 Sep 08; 281(36):26391-9. Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. PMID: 16818493.
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    152. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. J Biol Chem. 2006 Jun 23; 281(25):17173-17179. Swaney JS, Patel HH, Yokoyama U, Head BP, Roth DM, Insel PA. PMID: 16618703.
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    153. Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival. J Neurosci. 2006 Apr 05; 26(14):3798-804. Arthur DB, Georgi S, Akassoglou K, Insel PA. PMID: 16597733; PMCID: PMC6674138.
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    154. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenet Genomics. 2006 Mar; 16(3):199-205. Büscher R, Hoerning A, Patel HH, Zhang S, Arthur DB, Grasemann H, Ratjen F, Insel PA. PMID: 16495779.
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    155. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H344-50. Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth DM. PMID: 16501018.
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    156. Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension. 2006 Mar; 47(3):415-20. Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O'Connor DT, Insel PA. PMID: 16432041.
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    157. Methods for the study of signaling molecules in membrane lipid rafts and caveolae. Methods Mol Biol. 2006; 332:181-91. Ostrom RS, Insel PA. PMID: 16878693.
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    158. Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respir Physiol Neurobiol. 2006 Apr 28; 151(2-3):192-208. Murray F, Insel PA, Yuan JX. PMID: 16364695.
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    159. P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19138-43. Arthur DB, Akassoglou K, Insel PA. PMID: 16365320; PMCID: PMC1323158.
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    160. Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets. Expert Opin Ther Targets. 2005 Dec; 9(6):1247-65. Tang CM, Insel PA. PMID: 16300474.
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    161. Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1131-4. Insel PA, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. PMID: 16246064.
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    162. Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A. J Physiol. 2005 Nov 01; 568(Pt 3):789-801. Akimova AO, Bourcier N, Taurin S, Bundey RA, Grygorczyk K, Gekle M, Insel PA, Dulin NO, Orlov SN. PMID: 16109726; PMCID: PMC1464179.
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    163. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem. 2005 Sep 02; 280(35):31036-44. Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA. PMID: 15961389.
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    164. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8561-6. Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA. PMID: 15939874; PMCID: PMC1150853.
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    165. Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension. 2005 Jun; 45(6):1207-13. Etzel JP, Rana BK, Wen G, Parmer RJ, Schork NJ, O'Connor DT, Insel PA. PMID: 15920038.
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    166. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann N Y Acad Sci. 2005 Jun; 1047:166-72. Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. PMID: 16093494.
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    167. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. Clin Pharmacol Ther. 2005 May; 77(5):388-403. King D, Etzel JP, Chopra S, Smith J, Cadman PE, Rao F, Funk SD, Rana BK, Schork NJ, Insel PA, O'Connor DT. PMID: 15900285.
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    168. Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis. Pharmacogenet Genomics. 2005 May; 15(5):321-7. Tang CM, Hoerning A, Büscher R, O'Connor DT, Ratjen F, Grasemann H, Insel PA. PMID: 15864133.
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    169. Multi-tasking RGS proteins in the heart: the next therapeutic target? Circ Res. 2005 Mar 04; 96(4):401-11. Riddle EL, Schwartzman RA, Bond M, Insel PA. PMID: 15746448.
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    170. Receptor databases and computational websites for ligand binding. Methods Mol Biol. 2005; 306:1-15. Rana BK, Insel PA. PMID: 15867461.
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    171. Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):437-42. Swaney JS, Roth DM, Olson ER, Naugle JE, Meszaros JG, Insel PA. PMID: 15625103; PMCID: PMC544320.
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    172. Clarifying the effects of adrenergic receptor polymorphisms by measuring synaptic parameters. J Am Coll Cardiol. 2004 Nov 16; 44(10):2016-8. Siecke NW, Insel PA. PMID: 15542285.
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    173. Blasts from the past. J Clin Invest. 2004 Oct; 114(8):1017-33. Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD. PMID: 15489944; PMCID: PMC522273.
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    174. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol. 2004 Sep; 143(2):235-45. Ostrom RS, Insel PA. PMID: 15289291; PMCID: PMC1575337.
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    175. Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther. 2004 Aug; 76(2):139-53. Le Corre P, Parmer RJ, Kailasam MT, Kennedy BP, Skaar TP, Ho H, Leverge R, Smith DW, Ziegler MG, Insel PA, Schork NJ, Flockhart DA, O'connor DT. PMID: 15289791.
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    176. Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP? Sci STKE. 2004 Apr 28; 2004(231):pe19. Bundey RA, Insel PA. PMID: 15126677.
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    177. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J Leukoc Biol. 2004 Jul; 76(1):245-53. Chen Y, Shukla A, Namiki S, Insel PA, Junger WG. PMID: 15107462.
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    178. Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. J Biol Chem. 2004 Jun 18; 279(25):26176-83. Nishihara H, Hwang M, Kizaka-Kondoh S, Eckmann L, Insel PA. PMID: 15078890.
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    179. GPCR expression in the heart; "new" receptors in myocytes and fibroblasts. Trends Cardiovasc Med. 2004 Apr; 14(3):94-9. Tang CM, Insel PA. PMID: 15121156.
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    180. Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. J Biol Chem. 2004 May 07; 279(19):19846-53. Ostrom RS, Bundey RA, Insel PA. PMID: 15007069.
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    181. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem. 2004 May 14; 279(20):20858-65. Zhang L, Insel PA. PMID: 14996839.
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    182. Autonomic nervous system pharmacogenomics: a progress report. Pharmacol Rev. 2004 Mar; 56(1):31-52. Kirstein SL, Insel PA. PMID: 15001662.
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    183. cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. Am J Physiol Cell Physiol. 2004 May; 286(5):C1089-99. Liu X, Ostrom RS, Insel PA. PMID: 15075208.
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    184. Pharmacogenetics of hypertension treatment: a structured review. Pharmacogenetics. 2003 Dec; 13(12):705-13. Koopmans RP, Insel PA, Michel MC. PMID: 14646689.
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    185. Quantification of adenylyl cyclase messenger RNA by real-time polymerase chain reaction. Anal Biochem. 2003 Aug 15; 319(2):318-22. Bundey RA, Insel PA. PMID: 12871728.
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    186. Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1445-53. Brindikova TA, Bourcier N, Torres B, Pchejetski D, Gekle M, Maximov GV, Montminy V, Insel PA, Orlov SN, Isenring P. PMID: 12917108.
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    187. Naturally occurring variants in catecholamine receptor genes. Auton Autacoid Pharmacol. 2003 Aug; 23(4):228-30. Insel PA, Kirstein SL. PMID: 15132132.
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    188. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8921-6. Nishihara H, Kizaka-Kondoh S, Insel PA, Eckmann L. PMID: 12837940; PMCID: PMC166414.
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    189. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cell Mol Neurobiol. 2003 Jun; 23(3):305-14. Insel PA, Ostrom RS. PMID: 12825829.
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    190. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J Biol Chem. 2003 Jul 04; 278(27):24461-8. Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG. PMID: 12711600.
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    191. Location, location, location. Trends Endocrinol Metab. 2003 Apr; 14(3):100-2. Insel PA. PMID: 12670730.
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    192. 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. Circ Res. 2003 Apr 04; 92(6):676-82. Patel HH, Fryer RM, Gross ER, Bundey RA, Hsu AK, Isbell M, Eusebi LO, Jensen RV, Gullans SR, Insel PA, Nithipatikom K, Gross GJ. PMID: 12623876.
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    193. The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo. Pharmacogenetics. 2003 Feb; 13(2):59-66. Bruck H, Leineweber K, Büscher R, Ulrich A, Radke J, Insel PA, Brodde OE. PMID: 12563174.
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    194. Receptor gene polymorphisms: lessons on functional relevance from the beta 1-adrenoceptor. Br J Pharmacol. 2003 Jan; 138(2):279-82. Michel MC, Insel PA. PMID: 12540516; PMCID: PMC1573661.
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    195. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem. 2003 Feb 14; 278(7):4590-6. Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG. PMID: 12464620.
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    196. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Mol Pharmacol. 2002 Nov; 62(5):983-92. Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel PA. PMID: 12391260.
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    197. G-protein-coupled receptor websites. Trends Pharmacol Sci. 2002 Nov; 23(11):535-6. Rana BK, Insel PA. PMID: 12413809.
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    198. Adrenoceptors: a convergence of thinking. Mol Interv. 2002 Jul; 2(4):198-200. Michel MC, Jasper JR, Insel P. PMID: 14993387.
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    199. beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics. 2002 Jul; 12(5):347-53. Büscher R, Eilmes KJ, Grasemann H, Torres B, Knauer N, Sroka K, Insel PA, Ratjen F. PMID: 12142724.
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    200. P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D(1) cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation. J Biol Chem. 2002 Mar 08; 277(10):7761-5. Torres B, Zambon AC, Insel PA. PMID: 11788591.
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    201. P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides. Clin Exp Pharmacol Physiol. 2001 Apr; 28(4):351-4. Insel PA, Ostrom RS, Zambon AC, Hughes RJ, Balboa MA, Shehnaz D, Gregorian C, Torres B, Firestein BL, Xing M, Post SR. PMID: 11339212.
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