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Anjan Debnath

Title(s)Assistant Adjunct Professor, School of Pharmacy and Pharmaceutical Science
SchoolHealth Sciences
Address9500 Gilman Drive #0755
La Jolla CA 92093
Phone858-822-5265
ORCID ORCID Icon0000-0001-9294-392 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Annual Biomedical Research Conference for Minority Students (ABRCMS)2017  - 2020Judge Travel Award
    Sage Bionetworks2016Sage Scholar
    QB32012Deloitte QB3 Award for Innovation Finalist
    Keystone Symposia2012Bill & Melinda Gates Foundation Keystone Symposia Scholarship
    American Society for Microbiology2002UNESCO-American Society for Microbiology Travel Award
    Lady Tata Memorial Trust1998Lady Tata Memorial Trust Junior Scholarship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Drug development against Entamoeba histolytica
    NIH R21AI146651Mar 10, 2020 - Feb 28, 2022
    Role: Sub-contract PI
    HMG-CoA Reductase Inhibitors as New Drug Leads for Naegleria Infection
    NIH/NIAID R21AI146460Feb 1, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Exploring MetAP2 as a viable drug target for Entamoeba and Naegleria
    NIH R21AI142487Aug 20, 2019 - Jul 31, 2021
    Role: Sub-contract PI
    Brain Penetrant Microtubule-Stabilizers to Treat CNS-invasive Parasitic Diseases
    NIH/NIAID R21AI141210Feb 1, 2019 - Jan 31, 2021
    Role: Co-Principal Investigator
    BRAIN PENETRANT MICROTUBULE-STABILIZERS TO TREAT CNS-INVASIVE PARASITIC DISEASES
    NIH/NIAID R21AI141210Feb 1, 2019 - Jan 31, 2021
    Role: Co-Principal Investigator
    Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseases
    NIH/NIAID R21AI133394Jun 1, 2018 - May 31, 2020
    Role: Co-Principal Investigator
    UCSD KL2 Grant
    NIH/NCATS KL2TR001444Jul 1, 2016 - Jun 30, 2019
    Role: Principal Investigator
    Role Description: Institutional Award Recipient

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Domain-swap dimerization of Acanthamoeba castellanii CYP51 and a unique mechanism of inactivation by isavuconazole. Mol Pharmacol. 2020 Oct 02. Sharma V, Shing B, Hernandez-Alvarez L, Debnath A, Podust LM. PMID: 33008918.
      View in: PubMed   Mentions:    Fields:    
    2. HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri. ACS Chem Neurosci. 2020 Sep 03. Hahn HJ, Abagyan R, Podust LM, Roy S, Ali I, Debnath A. PMID: 32881478.
      View in: PubMed   Mentions:    Fields:    
    3. In Vitro Evaluation of Farnesyltransferase Inhibitor and its Effect in Combination with 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor against Naegleria fowleri. Pathogens. 2020 Aug 22; 9(9). Hahn HJ, Debnath A. PMID: 32842691.
      View in: PubMed   Mentions:
    4. In Vitro Effect of Pitavastatin and Its Synergistic Activity with Isavuconazole against Acanthamoeba castellanii. Pathogens. 2020 Aug 21; 9(9). Hahn HJ, Escrig JI, Shing B, Debnath A. PMID: 32825652.
      View in: PubMed   Mentions:
    5. Activity of Auranofin against Multiple Genotypes of Naegleria fowleri and Its Synergistic Effect with Amphotericin B In Vitro. ACS Chem Neurosci. 2020 Aug 19; 11(16):2464-2471. Escrig JI, Hahn HJ, Debnath A. PMID: 32392039.
      View in: PubMed   Mentions: 1     Fields:    
    6. The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii. Antimicrob Agents Chemother. 2020 04 21; 64(5). Shing B, Singh S, Podust LM, McKerrow JH, Debnath A. PMID: 32094126.
      View in: PubMed   Mentions: 1     Fields:    
    7. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Negl Trop Dis. 2020 03; 14(3):e0008150. Ehrenkaufer G, Li P, Stebbins EE, Kangussu-Marcolino MM, Debnath A, White CV, Moser MS, DeRisi J, Gisselberg J, Yeh E, Wang SC, Company AH, Monti L, Caffrey CR, Huston CD, Wang B, Singh U. PMID: 32196500.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia. Int J Parasitol Drugs Drug Resist. 2019 12; 11:80-94. Kangussu-Marcolino MM, Ehrenkaufer GM, Chen E, Debnath A, Singh U. PMID: 31707263.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    9. Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria fowleri Sterol ?8-?7-Isomerase and Phenotypic Assays. ACS Infect Dis. 2019 12 13; 5(12):2029-2038. Shi D, Chahal KK, Oto P, Nothias LF, Debnath A, McKerrow JH, Podust LM, Abagyan R. PMID: 31583882.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Predictors of Failure from Primary Therapy for Giardiasis in San Diego: A Single Institution Retrospective Review. Pathogens. 2019 Sep 27; 8(4). Debnath A, Reed SL, Morris SR. PMID: 31569735.
      View in: PubMed   Mentions:
    11. Editorial: Recent Progresses in Amebiasis. Front Cell Infect Microbiol. 2019; 9:247. Debnath A, Rodriguez MA, Ankri S. PMID: 31338336.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    12. Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni. Front Cell Infect Microbiol. 2019; 9:180. Probst A, Nguyen TN, El-Sakkary N, Skinner D, Suzuki BM, Buckner FS, Gelb MH, Caffrey CR, Debnath A. PMID: 31192168.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity. J Med Chem. 2018 12 27; 61(24):11349-11371. Jarrad AM, Ang CW, Debnath A, Hahn HJ, Woods K, Tan L, Sykes ML, Jones AJ, Pelingon R, Butler MS, Avery VM, West NP, Karoli T, Blaskovich MAT, Cooper MA. PMID: 30468386.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Highly Potent 1H-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, and Sexually-Transmitted Protozoal Parasites. Front Cell Infect Microbiol. 2018; 8:380. Kumar S, Bains T, Won Kim AS, Tam C, Kim J, Cheng LW, Land KM, Debnath A, Kumar V. PMID: 30425970.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. PLoS Pathog. 2018 09; 14(9):e1007245. Zhou W, Debnath A, Jennings G, Hahn HJ, Vanderloop BH, Chaudhuri M, Nes WD, Podust LM. PMID: 30212566.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Protozoan Parasitism: From Omics to Prevention and Control (Edited by: Luis Miguel de Pablos Torró and Jacob-Lorenzo Morales). Entamoeba histolytica: from high-throughput technology to new drugs. 2018; 157-170. Anjan Debnath and Sharon L Reed.. View Publication.
    17. Cysteine proteases in protozoan parasites. PLoS Negl Trop Dis. 2018 08; 12(8):e0006512. Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. PMID: 30138453.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    18. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri. Exp Parasitol. 2018 May; 188:36-41. Zyserman I, Mondal D, Sarabia F, McKerrow JH, Roush WR, Debnath A. PMID: 29551628.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    19. In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri. Front Microbiol. 2018; 9:414. Debnath A, Nelson AT, Silva-Olivares A, Shibayama M, Siegel D, McKerrow JH. PMID: 29559968.
      View in: PubMed   Mentions:
    20. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis. 2017 12; 11(12):e0006104. Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. PMID: 29284029.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Design, Synthesis and Preliminary Antimicrobial Evaluation of N-Alkyl Chain Tethered C-5 Functionalized Bis-Isatins. Medchemcomm. 2017; 8(10):1982-1992. Singh A, Bains T, Hahn HJ, Liu N, Tam C, Cheng LW, Kim J, Debnath A, Land KM, Kumar V. PMID: 29449910.
      View in: PubMed   Mentions:
    22. Drug Development for Parasite-induced Diarrheal Diseases. 2017. Anjan Debnath, James H. McKerrow.View Publication.
    23. Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri. PLoS Negl Trop Dis. 2017 Aug; 11(8):e0005832. Bashyal B, Li L, Bains T, Debnath A, LaBarbera DV. PMID: 28793307.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    24. Susceptibility Testing of Medically Important Parasites. Clin Microbiol Rev. 2017 07; 30(3):647-669. Genetu Bayih A, Debnath A, Mitre E, Huston CD, Laleu B, Leroy D, Blasco B, Campo B, Wells TNC, Willis PA, Sjö P, Van Voorhis WC, Pillai DR. PMID: 28446445.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    25. In vitro activity of selected Ghanaian medicinal plants against parasites: Giardia lamblia, Entamoeba histolytica and Naegleria fowleri. African Journal of Pharmacy and Pharmacology. 2017; 11(23):279-283. Gertrude Kyere-Davies, Christian Agyare, Yaw Duah Boakye, Trpta Bains, Brian M. Suzuki, James H. McKerrow, Conor R. Caffrey and Anjan Debnath.. View Publication.
    26. Nf-GH, a glycosidase secreted by Naegleria fowleri, causes mucin degradation: an in vitro and in vivo study. Future Microbiol. 2017 07; 12:781-799. Martínez-Castillo M, Cárdenas-Guerra RE, Arroyo R, Debnath A, Rodríguez MA, Sabanero M, Flores-Sánchez F, Navarro-Garcia F, Serrano-Luna J, Shibayama M. PMID: 28608712.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    27. Editorial: Drug Development for Parasite-Induced Diarrheal Diseases. Front Microbiol. 2017; 8:577. Debnath A, McKerrow JH. PMID: 28421063.
      View in: PubMed   Mentions:
    28. Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo. Int J Antimicrob Agents. 2016 Dec; 48(6):690-694. Hopper M, Yun JF, Zhou B, Le C, Kehoe K, Le R, Hill R, Jongeward G, Debnath A, Zhang L, Miyamoto Y, Eckmann L, Land KM, Wrischnik LA. PMID: 27839893.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    29. Naegleria fowleri after 50 years: is it a neglected pathogen? J Med Microbiol. 2016 Sep; 65(9):885-896. Martínez-Castillo M, Cárdenas-Zúñiga R, Coronado-Velázquez D, Debnath A, Serrano-Luna J, Shibayama M. PMID: 27381464.
      View in: PubMed   Mentions: 7     Fields:    
    30. Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. Eur J Med Chem. 2016 Sep 14; 120:353-62. Jarrad AM, Debnath A, Miyamoto Y, Hansford KA, Pelingon R, Butler MS, Bains T, Karoli T, Blaskovich MA, Eckmann L, Cooper MA. PMID: 27236016.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. PMID: 26876147.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. Eur J Med Chem. 2015 Aug 28; 101:96-102. Jarrad AM, Karoli T, Debnath A, Tay CY, Huang JX, Kaeslin G, Elliott AG, Miyamoto Y, Ramu S, Kavanagh AM, Zuegg J, Eckmann L, Blaskovich MA, Cooper MA. PMID: 26117821.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    33. Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Front Microbiol. 2015; 6:368. Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. PMID: 26029171.
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    34. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. PMID: 25700363.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    35. Amebiasis: Biology and Pathogenesis of Entamoeba. 2015; 553-564. Anjan Debnath.. View Publication.
    36. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. PMID: 24820073.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    37. In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts. Antimicrob Agents Chemother. 2014; 58(3):1523-8. Debnath A, Tunac JB, Silva-Olivares A, Galindo-Gómez S, Shibayama M, McKerrow JH. PMID: 24366747.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013 May; 57(5):2029-35. Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. PMID: 23403423.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    39. Reprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseases. Gut Microbes. 2013 Jan-Feb; 4(1):66-71. Debnath A, Ndao M, Reed SL. PMID: 23137963.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    40. Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen. Antimicrob Agents Chemother. 2012 Nov; 56(11):5450-7. Debnath A, Tunac JB, Galindo-Gómez S, Silva-Olivares A, Shibayama M, McKerrow JH. PMID: 22869574.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    41. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. PMID: 22610278.
      View in: PubMed   Mentions: 99     Fields:    Translation:Animals
    42. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. PMID: 21572521.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    43. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5128-31. Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK. PMID: 19648008.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    44. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72. Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. PMID: 17371810.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    45. Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria. Int J Parasitol. 2007 Jul; 37(8-9):897-906. Debnath A, Tashker JS, Sajid M, McKerrow JH. PMID: 17362964.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    46. A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2007 Feb; 115(2):192-9. Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. PMID: 16987516.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    47. Entamoeba histolytica: Characterization of human collagen type I and Ca2+ activated differentially expressed genes. Exp Parasitol. 2005 Jul; 110(3):214-9. Debnath A, Akbar MA, Mazumder A, Kumar S, Das P. PMID: 15955315.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica. J Infect Dis. 2004 Aug 01; 190(3):448-57. Debnath A, Das P, Sajid M, McKerrow JH. PMID: 15243916.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    49. Genes induced by a high-oxygen environment in Entamoeba histolytica. Mol Biochem Parasitol. 2004 Feb; 133(2):187-96. Akbar MA, Chatterjee NS, Sen P, Debnath A, Pal A, Bera T, Das P. PMID: 14698431.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    50. Characterization of plasma membrane-associated antigens of diagnostic and prophylactic importance in Entamoeba histolytica. Arch Med Res. 2000 Jul-Aug; 31(4 Suppl):S21-2. Mukhopadhyay P, Sengupta S, Akbar A, Sengupta K, Bhattacharya S, Debnath A, Ganguly S, Das P. PMID: 11070208.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    51. PCR detection of Giardia lamblia in stool: targeting intergenic spacer region of multicopy rRNA gene. Mol Cell Probes. 2000 Jun; 14(3):181-9. Ghosh S, Debnath A, Sil A, De S, Chattopadhyay DJ, Das P. PMID: 10860716.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    52. Molecular mechanisms of pathogenesis in amebiasis. Indian J Gastroenterol. 1999 Oct-Nov; 18(4):161-6. Das P, Debnath A, Muñoz ML. PMID: 10531719.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    53. Antigens of diagnostic and prophylactic importance inEntamoeba histolytica. Indian J Clin Biochem. 1998 Jan; 13(1):33-5. Bhattacharya S, Sengupta K, Sengupta S, Mukhopadhyay P, Debnath A, Das P. PMID: 23105180.
      View in: PubMed   Mentions: