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Anjan Debnath

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0755
La Jolla CA 92093
Phone858-822-5265
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    Collapse Biography 
    Collapse Awards and Honors
    Annual Biomedical Research Conference for Minority Students (ABRCMS)2017Judge Travel Award
    Sage Bionetworks2016Sage Scholar
    QB32012Deloitte QB3 Award for Innovation Finalist
    Keystone Symposia2012Bill & Melinda Gates Foundation Keystone Symposia Scholarship
    American Society for Microbiology2002UNESCO-American Society for Microbiology Travel Award
    Lady Tata Memorial Trust1998Lady Tata Memorial Trust Junior Scholarship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseases
    NIH/NIAID R21AI133394Jun 1, 2018 - May 31, 2020
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zyserman I, Mondal D, Sarabia F, McKerrow JH, Roush WR, Debnath A. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri. Exp Parasitol. 2018 Mar 15. PMID: 29551628.
      View in: PubMed
    2. Debnath A, Nelson AT, Silva-Olivares A, Shibayama M, Siegel D, McKerrow JH. In Vitro Efficacy of Ebselen and BAY 11-7082 AgainstNaegleria fowleri. Front Microbiol. 2018; 9:414. PMID: 29559968.
      View in: PubMed
    3. Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis. 2017 12; 11(12):e0006104. PMID: 29284029.
      View in: PubMed
    4. Singh A. Design, Synthesis and Preliminary Antimicrobial Evaluation ofN-Alkyl Chain Tethered C-5 Functionalized Bis-Isatins. Medchemcomm. 2017; 8(10):1982-1992. PMID: 29449910.
      View in: PubMed
    5. Anjan Debnath, James H. McKerrow.Drug Development for Parasite-induced Diarrheal Diseases. 2017.
    6. Bashyal B, Li L, Bains T, Debnath A, LaBarbera DV. Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri. PLoS Negl Trop Dis. 2017 Aug; 11(8):e0005832. PMID: 28793307.
      View in: PubMed
    7. Genetu Bayih A, Debnath A, Mitre E, Huston CD, Laleu B, Leroy D, Blasco B, Campo B, Wells TNC, Willis PA, Sjö P, Van Voorhis WC, Pillai DR. Susceptibility Testing of Medically Important Parasites. Clin Microbiol Rev. 2017 Jul; 30(3):647-669. PMID: 28446445.
      View in: PubMed
    8. Gertrude Kyere-Davies, Christian Agyare, Yaw Duah Boakye, Trpta Bains, Brian M. Suzuki, James H. McKerrow, Conor R. Caffrey and Anjan Debnath.In vitro activity of selected Ghanaian medicinal plants against parasites: Giardia lamblia, Entamoeba histolytica and Naegleria fowleri. African Journal of Pharmacy and Pharmacology. 2017; 11(23):279-283.
    9. Martínez-Castillo M, Cárdenas-Guerra RE, Arroyo R, Debnath A, Rodríguez MA, Sabanero M, Flores-Sánchez F, Navarro-Garcia F, Serrano-Luna J, Shibayama M. Nf-GH, a glycosidase secreted by Naegleria fowleri, causes mucin degradation: an in vitro and in vivo study. Future Microbiol. 2017 07; 12:781-799. PMID: 28608712.
      View in: PubMed
    10. Debnath A, McKerrow JH. Editorial: Drug Development for Parasite-Induced Diarrheal Diseases. Front Microbiol. 2017; 8:577. PMID: 28421063.
      View in: PubMed
    11. Hopper M, Yun JF, Zhou B, Le C, Kehoe K, Le R, Hill R, Jongeward G, Debnath A, Zhang L, Miyamoto Y, Eckmann L, Land KM, Wrischnik LA. Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo. Int J Antimicrob Agents. 2016 Dec; 48(6):690-694. PMID: 27839893.
      View in: PubMed
    12. Martínez-Castillo M, Cárdenas-Zúñiga R, Coronado-Velázquez D, Debnath A, Serrano-Luna J, Shibayama M. Naegleria fowleri after 50 Years: Is it a neglected pathogen? J Med Microbiol. 2016 Jul 04. PMID: 27381464.
      View in: PubMed
    13. Jarrad AM, Debnath A, Miyamoto Y, Hansford KA, Pelingon R, Butler MS, Bains T, Karoli T, Blaskovich MA, Eckmann L, Cooper MA. Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. Eur J Med Chem. 2016 Sep 14; 120:353-62. PMID: 27236016; PMCID: PMC4920673.
    14. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90. PMID: 26876147; PMCID: PMC5003402 [Available on 05/01/17].
    15. Jarrad AM, Karoli T, Debnath A, Tay CY, Huang JX, Kaeslin G, Elliott AG, Miyamoto Y, Ramu S, Kavanagh AM, Zuegg J, Eckmann L, Blaskovich MA, Cooper MA. Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. Eur J Med Chem. 2015 Aug 28; 101:96-102. PMID: 26117821; PMCID: PMC4550478.
    16. Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Front Microbiol. 2015; 6:368. PMID: 26029171; PMCID: PMC4429810.
    17. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. PMID: 25700363; PMCID: PMC4336141.
    18. Anjan Debnath.Amebiasis: Biology and Pathogenesis of Entamoeba. 2015; 553-564.
    19. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. PMID: 24820073; PMCID: PMC4068574.
    20. Debnath A, Tunac JB, Silva-Olivares A, Galindo-Gómez S, Shibayama M, McKerrow JH. In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts. Antimicrob Agents Chemother. 2014; 58(3):1523-8. PMID: 24366747; PMCID: PMC3957901.
    21. Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013 May; 57(5):2029-35. PMID: 23403423; PMCID: PMC3632933.
    22. Debnath A, Ndao M, Reed SL. Reprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseases. Gut Microbes. 2013 Jan-Feb; 4(1):66-71. PMID: 23137963; PMCID: PMC3555889.
    23. Debnath A, Tunac JB, Galindo-Gómez S, Silva-Olivares A, Shibayama M, McKerrow JH. Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen. Antimicrob Agents Chemother. 2012 Nov; 56(11):5450-7. PMID: 22869574; PMCID: PMC3486592.
    24. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60. PMID: 22610278; PMCID: PMC3411919.
    25. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. PMID: 21572521; PMCID: PMC3086806.
    26. Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5128-31. PMID: 19648008; PMCID: PMC2745105.
    27. Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72. PMID: 17371810.
      View in: PubMed
    28. Debnath A, Tashker JS, Sajid M, McKerrow JH. Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria. Int J Parasitol. 2007 Jul; 37(8-9):897-906. PMID: 17362964.
      View in: PubMed
    29. Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2007 Feb; 115(2):192-9. PMID: 16987516.
      View in: PubMed
    30. Debnath A, Akbar MA, Mazumder A, Kumar S, Das P. Entamoeba histolytica: Characterization of human collagen type I and Ca2+ activated differentially expressed genes. Exp Parasitol. 2005 Jul; 110(3):214-9. PMID: 15955315.
      View in: PubMed
    31. Debnath A, Das P, Sajid M, McKerrow JH. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica. J Infect Dis. 2004 Aug 01; 190(3):448-57. PMID: 15243916.
      View in: PubMed
    32. Akbar MA, Chatterjee NS, Sen P, Debnath A, Pal A, Bera T, Das P. Genes induced by a high-oxygen environment in Entamoeba histolytica. Mol Biochem Parasitol. 2004 Feb; 133(2):187-96. PMID: 14698431.
      View in: PubMed
    33. Mukhopadhyay P, Sengupta S, Akbar A, Sengupta K, Bhattacharya S, Debnath A, Ganguly S, Das P. Characterization of plasma membrane-associated antigens of diagnostic and prophylactic importance in Entamoeba histolytica. Arch Med Res. 2000 Jul-Aug; 31(4 Suppl):S21-2. PMID: 11070208.
      View in: PubMed
    34. Ghosh S, Debnath A, Sil A, De S, Chattopadhyay DJ, Das P. PCR detection of Giardia lamblia in stool: targeting intergenic spacer region of multicopy rRNA gene. Mol Cell Probes. 2000 Jun; 14(3):181-9. PMID: 10860716.
      View in: PubMed
    35. Das P, Debnath A, Muñoz ML. Molecular mechanisms of pathogenesis in amebiasis. Indian J Gastroenterol. 1999 Oct-Nov; 18(4):161-6. PMID: 10531719.
      View in: PubMed
    36. Bhattacharya S, Sengupta K, Sengupta S, Mukhopadhyay P, Debnath A, Das P. Antigens of diagnostic and prophylactic importance inEntamoeba histolytica. Indian J Clin Biochem. 1998 Jan; 13(1):33-5. PMID: 23105180; PMCID: PMC3453534.