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Alexander Groisman

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPhysics
Address9500 Gilman Drive #0374
La Jolla CA 92093
Phone858-822-1838
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    Collapse Research 
    Collapse Research Activities and Funding
    CHEMOTAXIS IN DICTYOSTELIUM DISCOIDEUM: AN INTEGRATIVE APPROACH
    NIH P01GM078586Jul 1, 2006 - Jul 31, 2017
    Role: Co-Investigator
    Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
    NIH/NHLBI P01HL078784Dec 1, 2004 - Apr 30, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang L, Bailey JB, Subramanian RH, Groisman A, Tezcan FA. Author Correction: Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks. Nature. 2018 Jul 04. PMID: 29973728.
      View in: PubMed
    2. Zhang L, Bailey JB, Subramanian RH, Groisman A, Tezcan FA. Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks. Nature. 2018 May; 557(7703):86-91. PMID: 29720635.
      View in: PubMed
    3. Malinowski PT, Cochet-Escartin O, Kaj KJ, Ronan E, Groisman A, Diamond PH, Collins ES. Mechanics dictate where and how freshwater planarians fission. Proc Natl Acad Sci U S A. 2017 Oct 10; 114(41):10888-10893. PMID: 28973880.
      View in: PubMed
    4. Cremer J, Segota I, Yang CY, Arnoldini M, Sauls JT, Zhang Z, Gutierrez E, Groisman A, Hwa T. Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11414-11419. PMID: 27681630.
      View in: PubMed
    5. Bober BG, Gutierrez E, Plaxe S, Groisman A, Shah SB. Combinatorial influences of paclitaxel and strain on axonal transport. Exp Neurol. 2015 Sep; 271:358-67. PMID: 26143110.
      View in: PubMed
    6. Erickstad M, Hale LA, Chalasani SH, Groisman A. A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia. Lab Chip. 2015 Feb 07; 15(3):857-66. PMID: 25490410.
      View in: PubMed
    7. Erickstad M, Gutierrez E, Groisman A. A low-cost low-maintenance ultraviolet lithography light source based on light-emitting diodes. Lab Chip. 2015 Jan 07; 15(1):57-61. PMID: 25322205.
      View in: PubMed
    8. Polinkovsky ME, Gambin Y, Banerjee PR, Erickstad MJ, Groisman A, Deniz AA. Ultrafast cooling reveals microsecond-scale biomolecular dynamics. Nat Commun. 2014 Dec 17; 5:5737. PMID: 25517430.
      View in: PubMed
    9. Skoge M, Yue H, Erickstad M, Bae A, Levine H, Groisman A, Loomis WF, Rappel WJ. Cellular memory in eukaryotic chemotaxis. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14448-53. PMID: 25249632; PMCID: PMC4210025.
    10. Manthey CF, Calabio CB, Wosinski A, Hanson EM, Vallance BA, Groisman A, Martín MG, Wang JY, Eckmann L. Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions. Am J Physiol Cell Physiol. 2014 Jul 15; 307(2):C180-9. PMID: 24848114; PMCID: PMC4101622.
    11. Deris JB, Kim M, Zhang Z, Okano H, Hermsen R, Groisman A, Hwa T. The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria. Science. 2013 Nov 29; 342(6162):1237435. PMID: 24288338; PMCID: PMC4059556.
    12. Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg MH. The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open. 2013; 2(10):1007-12. PMID: 24167710; PMCID: PMC3798183.
    13. Adler M, Erickstad M, Gutierrez E, Groisman A. Studies of bacterial aerotaxis in a microfluidic device. Lab Chip. 2012 Nov 21; 12(22):4835-47. PMID: 23010909; PMCID: PMC3520485.
    14. Razooky BS, Gutierrez E, Terry VH, Spina CA, Groisman A, Weinberger LS. Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes. Lab Chip. 2012 Nov 07; 12(21):4305-12. PMID: 22976503; PMCID: PMC3589574.
    15. Loomis WF, Fuller D, Gutierrez E, Groisman A, Rappel WJ. Innate non-specific cell substratum adhesion. PLoS One. 2012; 7(8):e42033. PMID: 22952588; PMCID: PMC3432024.
    16. Adler M, Groisman A. Linear conversion of pressure into concentration, rapid switching of concentration, and generation of linear ramps of concentration in a microfluidic device. Biomicrofluidics. 2012 Jun; 6(2):24109-2410916. PMID: 22550555; PMCID: PMC3338547.
    17. Takeda K, Shao D, Adler M, Charest PG, Loomis WF, Levine H, Groisman A, Rappel WJ, Firtel RA. Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal. 2012 Jan 03; 5(205):ra2. PMID: 22215733; PMCID: PMC3928814.
    18. Kim M, Zhang Z, Okano H, Yan D, Groisman A, Hwa T. Need-based activation of ammonium uptake in Escherichia coli. Mol Syst Biol. 2012; 8:616. PMID: 23010999; PMCID: PMC3472687.
    19. Gutierrez E, Groisman A. Measurements of elastic moduli of silicone gel substrates with a microfluidic device. PLoS One. 2011; 6(9):e25534. PMID: 21980487; PMCID: PMC3184124.
    20. Gutierrez E, Tkachenko E, Besser A, Sundd P, Ley K, Danuser G, Ginsberg MH, Groisman A. High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One. 2011; 6(9):e23807. PMID: 21961031; PMCID: PMC3178539.
    21. Carvalho A, Olson SK, Gutierrez E, Zhang K, Noble LB, Zanin E, Desai A, Groisman A, Oegema K. Acute drug treatment in the early C. elegans embryo. PLoS One. 2011; 6(9):e24656. PMID: 21935434.
      View in: PubMed
    22. Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH. Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol. 2011 Jun; 13(6):660-7. PMID: 21572420; PMCID: PMC3746034.
    23. Sundd P, Gutierrez E, Pospieszalska MK, Zhang H, Groisman A, Ley K. Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling. Nat Methods. 2010 Oct; 7(10):821-4. PMID: 20871617; PMCID: PMC2967732.
    24. Adler M, Polinkovsky M, Gutierrez E, Groisman A. Generation of oxygen gradients with arbitrary shapes in a microfluidic device. Lab Chip. 2010 Feb 07; 10(3):388-91. PMID: 20091013; PMCID: PMC2887752.
    25. Vandelinder V, Ferreon AC, Gambin Y, Deniz AA, Groisman A. High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device. Anal Chem. 2009 Aug 15; 81(16):6929-35. PMID: 19555081; PMCID: PMC2846235.
    26. Polinkovsky M, Gutierrez E, Levchenko A, Groisman A. Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures. Lab Chip. 2009 Apr 21; 9(8):1073-84. PMID: 19350089.
      View in: PubMed
    27. Tkachenko E, Gutierrez E, Ginsberg MH, Groisman A. An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip. 2009 Apr 21; 9(8):1085-95. PMID: 19350090; PMCID: PMC2742503.
    28. Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell. 2008 Nov; 19(11):4930-41. PMID: 18784251; PMCID: PMC2575143.
    29. Groisman A, Zamek S, Campbell K, Pang L, Levy U, Fainman Y. Optofluidic 1x4 switch. Opt Express. 2008 Sep 01; 16(18):13499-508. PMID: 18772958.
      View in: PubMed
    30. Latz MI, Bovard M, VanDelinder V, Segre E, Rohr J, Groisman A. Bioluminescent response of individual dinoflagellate cells to hydrodynamic stress measured with millisecond resolution in a microfluidic device. J Exp Biol. 2008 Sep; 211(Pt 17):2865-75. PMID: 18723546.
      View in: PubMed
    31. Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A. Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip. 2008 Sep; 8(9):1486-95. PMID: 18818803; PMCID: PMC2683765.
    32. Shefi O, Simonnet C, Groisman A, Macagno ER. Localized RNAi and ectopic gene expression in the medicinal leech. J Vis Exp. 2008 Apr 17; (14). PMID: 19066579; PMCID: PMC2582852.
    33. Ley K, Mestas J, Pospieszalska MK, Sundd P, Groisman A, Zarbock A. Chapter 11. Intravital microscopic investigation of leukocyte interactions with the blood vessel wall. Methods Enzymol. 2008; 445:255-79. PMID: 19022063.
      View in: PubMed
    34. Gutierrez E, Groisman A. Quantitative measurements of the strength of adhesion of human neutrophils to a substratum in a microfluidic device. Anal Chem. 2007 Mar 15; 79(6):2249-58. PMID: 17305308.
      View in: PubMed
    35. VanDelinder V, Groisman A. Perfusion in microfluidic cross-flow: separation of white blood cells from whole blood and exchange of medium in a continuous flow. Anal Chem. 2007 Mar 01; 79(5):2023-30. PMID: 17249639.
      View in: PubMed
    36. Campbell K, Groisman A. Generation of complex concentration profiles in microchannels in a logarithmically small number of steps. Lab Chip. 2007 Feb; 7(2):264-72. PMID: 17268630.
      View in: PubMed
    37. Simonnet C, Groisman A. High-throughput and high-resolution flow cytometry in molded microfluidic devices. Anal Chem. 2006 Aug 15; 78(16):5653-63. PMID: 16906708.
      View in: PubMed
    38. Shefi O, Simonnet C, Baker MW, Glass JR, Macagno ER, Groisman A. Microtargeted gene silencing and ectopic expression in live embryos using biolistic delivery with a pneumatic capillary gun. J Neurosci. 2006 Jun 07; 26(23):6119-23. PMID: 16763019.
      View in: PubMed
    39. VanDelinder V, Groisman A. Separation of plasma from whole human blood in a continuous cross-flow in a molded microfluidic device. Anal Chem. 2006 Jun 01; 78(11):3765-71. PMID: 16737235.
      View in: PubMed
    40. Groisman A, Lobo C, Cho H, Campbell JK, Dufour YS, Stevens AM, Levchenko A. A microfluidic chemostat for experiments with bacterial and yeast cells. Nat Methods. 2005 Sep; 2(9):685-9. PMID: 16118639.
      View in: PubMed
    41. Simonnet C, Groisman A. Chaotic mixing in a steady flow in a microchannel. Phys Rev Lett. 2005 Apr 08; 94(13):134501. PMID: 15903994.
      View in: PubMed