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Randal Kaufman

Title(s)Adjunct Professor, Pharmacology
SchoolHealth Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    A Novel Role for the UPR Component, ATF6 in AD-associated Neuroprotective Pathways
    NIH/NIA R01AG062190Mar 1, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Mechanism of ER protein misfolding-induced mitochondrial dysfunction
    NIH/NIDDK R01DK113171Sep 18, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Modifiers of Proinsulin Influence T2D Susceptibility
    NIH/NIDDK R24DK110973Sep 12, 2016 - Jun 30, 2020
    Role: Principal Investigator
    ER stress and UPR in non-alcoholic steatohepatitis and hepatocellular carcinoma
    NIH/NCI R01CA198103May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Homeostatic Role of IRE1a-XBP1-PDI1 in Hepatic Lipid Metabolism
    NIH/NIDDK R01DK103185Apr 1, 2015 - Mar 31, 2020
    Role: Principal Investigator
    eIF2a phosphorylation as a novel druggable target in CRPC
    NIH/NCI R21CA190588Jan 5, 2015 - Dec 31, 2016
    Role: Co-Principal Investigator
    Alteration in protein interactions with proinsulin and insulin in type 2 diabetes
    NIH/NIDDK R24DK093074Sep 1, 2011 - Feb 28, 2013
    Role: Principal Investigator
    Regulation of ER stress-induced cell death
    NIH/NIDDK R01DK088227Sep 1, 2010 - May 31, 2015
    Role: Principal Investigator
    HTP chemical genomic screens to identify positive regulators of the Unfolded Prot
    NIH/NIMH R03MH089782Sep 30, 2009 - May 31, 2011
    Role: Principal Investigator
    High Throughput Chemical Genomics to Identify Novel Inhibitors of CHOP
    NIH/NIMH R03MH084182Jun 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Unfolded proteins in the Endoplasmic Reticulum to Disease
    NIH/NIDDK R13DK079785Jul 15, 2007 - Jun 30, 2008
    Role: Principal Investigator
    Conformational Diseases of the Secretory Pathway
    NIH/NIDDK R13DK063935Jan 15, 2003 - Dec 31, 2003
    Role: Principal Investigator
    Role of the Unfolded Protein Response in Beta Cell
    NIH/NIDDK R37DK042394Jan 1, 1998 - Aug 31, 2017
    Role: Principal Investigator
    Unfolded Protein Response in Glucose Homeostasis
    NIH/NIDDK R01DK042394Jan 1, 1998 - Jun 30, 2007
    Role: Principal Investigator
    TRANSLATIONAL CONTROL IN REGULATION OF APOPTOSIS
    NIH/NIAID R01AI042394Jan 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    Regulation of Factor FVIII Secretion
    NIH/NHLBI R01HL052173Aug 1, 1995 - Jun 30, 2015
    Role: Principal Investigator
    ADENOVIRUS--MEDIATED DELIVERY OF NOVEL FACTOR VIII
    NIH/NHLBI R01HL053777Sep 30, 1994 - Aug 31, 2002
    Role: Principal Investigator
    GENETIC ENGINEERING OF AN IMPROVED FACTOR VIII PRODUCT
    NIH/NHLBI R44HL035946Mar 1, 1988 - Feb 28, 1990
    Role: Principal Investigator
    PRODUCTION OF MONOCLONAL ANTIBODIES IN TRANSGENIC MICE
    NIH/NIGMS R44GM037329Jul 1, 1986 - Aug 31, 1990
    Role: Principal Investigator
    PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES
    NIH/NIGMS R43GM037329Jul 1, 1986 - Dec 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 Sep 20; 175(1):133-145.e15. PMID: 30220454.
      View in: PubMed
    2. Chiang WC, Chan P, Wissinger B, Vincent A, Skorczyk-Werner A, Krawczynski MR, Kaufman RJ, Tsang SH, Héon E, Kohl S, Lin JH. Achromatopsia mutations target sequential steps of ATF6 activation. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):400-405. PMID: 28028229.
      View in: PubMed
    3. Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjevic K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M. eIF2a-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons. Elife. 2016 12 13; 5. PMID: 27960077.
      View in: PubMed
    4. Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, Hollander AI, Cremers FP, Lopez I, Ren H, Moore AT, Webster AR, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin JH. Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet. 2015 Jul; 47(7):757-65. PMID: 26029869; PMCID: PMC4610820.
    5. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343. PMID: 25132496; PMCID: PMC4165611.
    6. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a. Nat Neurosci. 2014 Aug; 17(8):1073-82. PMID: 24974795; PMCID: PMC4340591.
    7. Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal. 2014 Jul 20; 21(3):396-413. PMID: 24702237; PMCID: PMC4076992.
    8. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. PMID: 24917591; PMCID: PMC4984425.
    9. Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May; 10(5):e1004348. PMID: 24809345; PMCID: PMC4014425.
    10. Cao SS, Wang M, Harrington JC, Chuang BM, Eckmann L, Kaufman RJ. Phosphorylation of eIF2a is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice. Inflamm Bowel Dis. 2014 Apr; 20(4):712-22. PMID: 24577114.
      View in: PubMed
    11. Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin JH. Translational and posttranslational regulation of XIAP by eIF2a and ATF4 promotes ER stress-induced cell death during the unfolded protein response. Mol Biol Cell. 2014 May; 25(9):1411-20. PMID: 24623724; PMCID: PMC4004591.
    12. Ferris SP, Kodali VK, Kaufman RJ. Glycoprotein folding and quality-control mechanisms in protein-folding diseases. Dis Model Mech. 2014 Mar; 7(3):331-41. PMID: 24609034.
      View in: PubMed
    13. Kaufman RJ, Powell JS. Molecular approaches for improved clotting factors for hemophilia. Blood. 2013 Nov 21; 122(22):3568-74. PMID: 24065241; PMCID: PMC3837506.
    14. Ferris SP, Jaber NS, Molinari M, Arvan P, Kaufman RJ. UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum. Mol Biol Cell. 2013 Sep; 24(17):2597-608. PMID: 23864712.
      View in: PubMed
    15. Cao SS, Kaufman RJ. PKR in DSS-induced colitis: a matter of genetic background and maternal microflora? Inflamm Bowel Dis. 2013 Mar; 19(3):E49-50. PMID: 22508268.
      View in: PubMed
    16. Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 2013 May; 144(5):989-1000.e6. PMID: 23336977.
      View in: PubMed
    17. Cao SS, Kaufman RJ. Targeting endoplasmic reticulum stress in metabolic disease. Expert Opin Ther Targets. 2013 Apr; 17(4):437-48. PMID: 23324104.
      View in: PubMed
    18. Hassler J, Cao SS, Kaufman RJ. IRE1, a double-edged sword in pre-miRNA slicing and cell death. Dev Cell. 2012 Nov 13; 23(5):921-3. PMID: 23153490; PMCID: PMC3684431.
    19. Cao SS, Kaufman RJ. Unfolded protein response. Curr Biol. 2012 Aug 21; 22(16):R622-6. PMID: 22917505.
      View in: PubMed
    20. Cao SS, Song B, Kaufman RJ. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis. 2012 Sep; 18(9):1735-42. PMID: 22275310.
      View in: PubMed
    21. Cao SS, Kaufman RJ. iRhoms: ERADicating the messenger in growth control signaling. Dev Cell. 2011 Apr 19; 20(4):414-6. PMID: 21497754; PMCID: PMC3408039.
    22. Kaufman RJ, Cao S. Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism. EMBO Mol Med. 2010 Jun; 2(6):189-92. PMID: 20533428; PMCID: PMC3042734.
    23. DuRose JB, Scheuner D, Kaufman RJ, Rothblum LI, Niwa M. Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Mol Cell Biol. 2009 Aug; 29(15):4295-307. PMID: 19470760; PMCID: PMC2715810.
    24. Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, Yau GD, Kaufman RJ. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell. 2008 Dec; 15(6):829-40. PMID: 19081072.
      View in: PubMed
    25. Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell. 2007 Sep; 18(9):3681-91. PMID: 17567950.
      View in: PubMed
    26. Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 2006 Nov; 4(11):e374. PMID: 17090218.
      View in: PubMed
    27. Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol. 2006 Oct; 8(10):1053-63. PMID: 16964246.
      View in: PubMed
    28. Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY. Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem. 2006 Oct 20; 281(42):31440-7. PMID: 16928686.
      View in: PubMed
    29. Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ. Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem. 2006 Jul 28; 281(30):21458-68. PMID: 16717090.
      View in: PubMed
    30. Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol. 2005 Jun 20; 169(6):871-84. PMID: 15967811; PMCID: PMC2171635.
    31. Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest. 2005 Feb; 115(2):268-81. PMID: 15690081.
      View in: PubMed
    32. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5. PMID: 15029200.
      View in: PubMed
    33. Tardif KD, Mori K, Kaufman RJ, Siddiqui A. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem. 2004 Apr 23; 279(17):17158-64. PMID: 14960590.
      View in: PubMed
    34. Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ, Lee AS. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem. 2003 Jun 06; 278(23):20915-24. PMID: 12665508.
      View in: PubMed