Randal Kaufman

Title(s)Adjunct Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    A Novel Role for the UPR Component, ATF6 in AD-associated Neuroprotective Pathways
    NIH R01AG062190Mar 1, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Mechanism of ER Protein Misfolding-Induced Mitochondrial Dysfunction
    NIH R01DK113171Sep 18, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Modifiers of Proinsulin Influence T2D Susceptibility
    NIH R24DK110973Sep 12, 2016 - Jun 30, 2020
    Role: Principal Investigator
    ER stress and UPR in non-alcoholic steatohepatitis and hepatocellular carcinoma
    NIH R01CA198103May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Homeostatic Role of IRE1a-XBP1-PDI1 in Hepatic Lipid Metabolism
    NIH R01DK103185Apr 1, 2015 - Dec 31, 2020
    Role: Principal Investigator
    eIF2a phosphorylation as a novel druggable target in CRPC
    NIH R21CA190588Jan 5, 2015 - Dec 31, 2016
    Role: Co-Principal Investigator
    Alteration in protein interactions with proinsulin and insulin in type 2 diabetes
    NIH R24DK093074Sep 1, 2011 - Feb 28, 2013
    Role: Principal Investigator
    Regulation of ER stress-induced cell death
    NIH R01DK088227Sep 1, 2010 - May 31, 2015
    Role: Principal Investigator
    HTP chemical genomic screens to identify positive regulators of the Unfolded Prot
    NIH R03MH089782Sep 30, 2009 - May 31, 2011
    Role: Principal Investigator
    High Throughput Chemical Genomics to Identify Novel Inhibitors of CHOP
    NIH R03MH084182Jun 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Unfolded proteins in the Endoplasmic Reticulum to Disease
    NIH R13DK079785Jul 15, 2007 - Jun 30, 2008
    Role: Principal Investigator
    Conformational Diseases of the Secretory Pathway
    NIH R13DK063935Jan 15, 2003 - Dec 31, 2003
    Role: Principal Investigator
    Role of the Unfolded Protein Response in Beta Cell
    NIH R37DK042394Jan 1, 1998 - Aug 31, 2017
    Role: Principal Investigator
    Unfolded Protein Response in Glucose Homeostasis
    NIH R01DK042394Jan 1, 1998 - Jun 30, 2007
    Role: Principal Investigator
    TRANSLATIONAL CONTROL IN REGULATION OF APOPTOSIS
    NIH R01AI042394Jan 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    Regulation of Factor FVIII Secretion
    NIH R01HL052173Aug 1, 1995 - Sep 30, 2015
    Role: Principal Investigator
    ADENOVIRUS--MEDIATED DELIVERY OF NOVEL FACTOR VIII
    NIH R01HL053777Sep 30, 1994 - Aug 31, 2002
    Role: Principal Investigator
    GENETIC ENGINEERING OF AN IMPROVED FACTOR VIII PRODUCT
    NIH R44HL035946Mar 1, 1988 - Feb 28, 1990
    Role: Principal Investigator
    PRODUCTION OF MONOCLONAL ANTIBODIES IN TRANSGENIC MICE
    NIH R44GM037329Jul 1, 1986 - Aug 31, 1990
    Role: Principal Investigator
    PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES
    NIH R43GM037329Jul 1, 1986 - Dec 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts. Circulation. 2024 Sep 24; 150(13):1010-1029. Li C, Li S, Zhang G, Li Q, Song W, Wang X, Cook JA, van der Stoel M, Wright BW, Altamirano F, Niewold EL, Han J, Kimble G, Zhang P, Luo X, Urra H, May HI, Ferdous A, Sun XN, Deng Y, Ikonen E, Hetz C, Kaufman RJ, Zhang K, Gillette TG, Scherer PE, Hill JA, Chen J, Wang ZV. PMID: 38836349; PMCID: PMC11427172.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease. J Clin Invest. 2024 May 09; 134(13). Cao S, Fachi JL, Ma K, Ulezko Antonova A, Wang Q, Cai Z, Kaufman RJ, Ciorba MA, Deepak P, Colonna M. PMID: 38722686; PMCID: PMC11214543.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis. Protein Sci. 2024 Apr; 33(4):e4949. Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. PMID: 38511500; PMCID: PMC10955614.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. ATF6 protects against protein misfolding during cardiac hypertrophy. J Mol Cell Cardiol. 2024 Apr; 189:12-24. Hofmann C, Aghajani M, Alcock CD, Blackwood EA, Sandmann C, Herzog N, Groß J, Plate L, Wiseman RL, Kaufman RJ, Katus HA, Jakobi T, Völkers M, Glembotski CC, Doroudgar S. PMID: 38401179.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion. Mol Metab. 2024 Feb; 80:101874. Chen Z, Wang S, Pottekat A, Duffey A, Jang I, Chang BH, Cho J, Finck BN, Davidson NO, Kaufman RJ. PMID: 38211723; PMCID: PMC10832468.
      View in: PubMed   Mentions:    Fields:    
    6. Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells. Cell Rep. 2024 01 23; 43(1):113615. Amiri M, Kiniry SJ, Possemato AP, Mahmood N, Basiri T, Dufour CR, Tabatabaei N, Deng Q, Bellucci MA, Harwalkar K, Stokes MP, Giguère V, Kaufman RJ, Yamanaka Y, Baranov PV, Tahmasebi S, Sonenberg N. PMID: 38159280; PMCID: PMC10962698.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Cellular stress and coagulation factor production: when more is not necessarily better. J Thromb Haemost. 2023 12; 21(12):3329-3341. Chen Z, Herzog RW, Kaufman RJ. PMID: 37839613; PMCID: PMC10760459.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    8. mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2023 08 01; 325(2):H311-H320. Hofmann C, Löwenthal Z, Aghajani M, Kaufman RJ, Katus HA, Frey N, Glembotski CC, Völkers M, Doroudgar S. PMID: 37294892; PMCID: PMC10393365.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    9. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol. 2023 08; 79(2):362-377. He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M. PMID: 36996941; PMCID: PMC11332364.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    10. Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress. Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2214957119. Hung HH, Nagatsuka Y, Soldà T, Kodali VK, Iwabuchi K, Kamiguchi H, Kano K, Matsuo I, Ikeda K, Kaufman RJ, Molinari M, Greimel P, Hirabayashi Y. PMID: 36508673; PMCID: PMC9907099.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets. J Clin Endocrinol Metab. 2022 11 23; 107(11):3100-3110. Tran DT, Pottekat A, Lee K, Raghunathan M, Loguercio S, Mir SA, Paton AW, Paton JC, Arvan P, Kaufman RJ, Itkin-Ansari P. PMID: 36017587; PMCID: PMC10233482.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma. Mol Ther. 2022 12 07; 30(12):3542-3551. Kapelanski-Lamoureux A, Chen Z, Gao ZH, Deng R, Lazaris A, Lebeaupin C, Giles L, Malhotra J, Yong J, Zou C, de Jong YP, Metrakos P, Herzog RW, Kaufman RJ. PMID: 36242517; PMCID: PMC9734080.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    13. ER stress and inflammation crosstalk in obesity. Med Res Rev. 2023 01; 43(1):5-30. Ajoolabady A, Lebeaupin C, Wu NN, Kaufman RJ, Ren J. PMID: 35975736.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    14. Endoplasmic reticulum stress in liver diseases. Hepatology. 2023 02 01; 77(2):619-639. Ajoolabady A, Kaplowitz N, Lebeaupin C, Kroemer G, Kaufman RJ, Malhi H, Ren J. PMID: 35524448; PMCID: PMC9637239.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    15. In Vitro Stimulation of IRE1α/XBP1-Deficient B Cells with LPS. Methods Mol Biol. 2022; 2378:221-231. Zhu H, Jiang C, Kaufman RJ, Li H, Singh N. PMID: 34985703; PMCID: PMC9382655.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model. Sci Rep. 2021 08 11; 11(1):16356. Lee EJ, Chan P, Chea L, Kim K, Kaufman RJ, Lin JH. PMID: 34381136; PMCID: PMC8357971.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice. Sci Transl Med. 2021 07 28; 13(604). Yong J, Parekh VS, Reilly SM, Nayak J, Chen Z, Lebeaupin C, Jang I, Zhang J, Prakash TP, Sun H, Murray S, Guo S, Ayala JE, Satin LS, Saltiel AR, Kaufman RJ. PMID: 34321322; PMCID: PMC8557800.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    18. Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus. Nat Rev Endocrinol. 2021 08; 17(8):455-467. Yong J, Johnson JD, Arvan P, Han J, Kaufman RJ. PMID: 34163039; PMCID: PMC8765009.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    19. Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy. J Neurosci. 2021 05 19; 41(20):4536-4548. Sidoli M, Reed CB, Scapin C, Paez P, Cavener DR, Kaufman RJ, D'Antonio M, Feltri ML, Wrabetz L. PMID: 33879538; PMCID: PMC8152608.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Normal and defective pathways in biogenesis and maintenance of the insulin storage pool. J Clin Invest. 2021 01 19; 131(2). Liu M, Huang Y, Xu X, Li X, Alam M, Arunagiri A, Haataja L, Ding L, Wang S, Itkin-Ansari P, Kaufman RJ, Tsai B, Qi L, Arvan P. PMID: 33463547; PMCID: PMC7810482.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    21. Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum. Prog Mol Subcell Biol. 2021; 59:115-143. Poothong J, Jang I, Kaufman RJ. PMID: 34050864; PMCID: PMC8802734.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nat Neurosci. 2021 02; 24(2):204-213. Kalish BT, Kim E, Finander B, Duffy EE, Kim H, Gilman CK, Yim YS, Tong L, Kaufman RJ, Griffith EC, Choi GB, Greenberg ME, Huh JR. PMID: 33361822; PMCID: PMC7854524.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    23. eIF2α controls memory consolidation via excitatory and somatostatin neurons. Nature. 2020 10; 586(7829):412-416. Sharma V, Sood R, Khlaifia A, Eslamizade MJ, Hung TY, Lou D, Asgarihafshejani A, Lalzar M, Kiniry SJ, Stokes MP, Cohen N, Nelson AJ, Abell K, Possemato AP, Gal-Ben-Ari S, Truong VT, Wang P, Yiannakas A, Saffarzadeh F, Cuello AC, Nader K, Kaufman RJ, Costa-Mattioli M, Baranov PV, Quintana A, Sanz E, Khoutorsky A, Lacaille JC, Rosenblum K, Sonenberg N. PMID: 33029011; PMCID: PMC7874887.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    24. Phosphorylation of eIF2α Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR. J Neurosci. 2020 10 14; 40(42):8174-8187. Scapin C, Ferri C, Pettinato E, Bianchi F, Del Carro U, Feltri ML, Kaufman RJ, Wrabetz L, D'Antonio M. PMID: 32973043; PMCID: PMC7574653.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology. 2020 10; 159(4):1487-1503.e17. Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H. PMID: 32574624; PMCID: PMC7666601.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    26. Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. Diabetes. 2020 08; 69(8):1723-1734. Tran DT, Pottekat A, Mir SA, Loguercio S, Jang I, Campos AR, Scully KM, Lahmy R, Liu M, Arvan P, Balch WE, Kaufman RJ, Itkin-Ansari P. PMID: 32457219; PMCID: PMC7372081.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    27. Mechanisms, regulation and functions of the unfolded protein response. Nat Rev Mol Cell Biol. 2020 08; 21(8):421-438. Hetz C, Zhang K, Kaufman RJ. PMID: 32457508; PMCID: PMC8867924.
      View in: PubMed   Mentions: 811     Fields:    Translation:HumansAnimalsCells
    28. Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum. Blood. 2020 05 21; 135(21):1899-1911. Poothong J, Pottekat A, Siirin M, Campos AR, Paton AW, Paton JC, Lagunas-Acosta J, Chen Z, Swift M, Volkmann N, Hanein D, Yong J, Kaufman RJ. PMID: 32128578; PMCID: PMC7243144.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    29. Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth. Diabetes. 2020 05; 69(5):954-964. Sun J, Xiong Y, Li X, Haataja L, Chen W, Mir SA, Lv L, Madley R, Larkin D, Anjum A, Dhayalan B, Rege N, Wickramasinghe NP, Weiss MA, Itkin-Ansari P, Kaufman RJ, Ostrov DA, Arvan P, Liu M. PMID: 32139596; PMCID: PMC7171958.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    30. The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts. Int J Mol Sci. 2020 Feb 18; 21(4). Stauffer WT, Blackwood EA, Azizi K, Kaufman RJ, Glembotski CC. PMID: 32085622; PMCID: PMC7073073.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    31. The Impact of the ER Unfolded Protein Response on Cancer Initiation and Progression: Therapeutic Implications. Adv Exp Med Biol. 2020; 1243:113-131. Lebeaupin C, Yong J, Kaufman RJ. PMID: 32297215; PMCID: PMC7243802.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Development of a Reporter System Monitoring Regulated Intramembrane Proteolysis of the Transmembrane bZIP Transcription Factor ATF6α. Mol Cells. 2019 Nov 30; 42(11):783-793. Kim JI, Kaufman RJ, Back SH, Moon JY. PMID: 31707777; PMCID: PMC6883980.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    33. The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. Neuron. 2019 11 20; 104(4):724-735.e6. Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R. PMID: 31522764; PMCID: PMC6872934.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    34. Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2. Elife. 2019 09 09; 8. Yong J, Bischof H, Burgstaller S, Siirin M, Murphy A, Malli R, Kaufman RJ. PMID: 31498082; PMCID: PMC6763289.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    35. Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol. 2019 Jul; 21(7):913. Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C. PMID: 31201389; PMCID: PMC7292237.
      View in: PubMed   Mentions: 4     Fields:    
    36. Proinsulin misfolding is an early event in the progression to type 2 diabetes. Elife. 2019 06 11; 8. Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. PMID: 31184302; PMCID: PMC6559786.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    37. PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity. Elife. 2019 06 11; 8. Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ. PMID: 31184304; PMCID: PMC6559792.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    38. Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol. 2019 06; 21(6):755-767. Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C. PMID: 31110288; PMCID: PMC7246037.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    39. Targeting the unfolded protein response in head and neck and oral cavity cancers. Exp Cell Res. 2019 09 01; 382(1):111386. Cole DW, Svider PF, Shenouda KG, Lee PB, Yoo NG, McLeod TM, Mutchnick SA, Yoo GH, Kaufman RJ, Callaghan MU, Fribley AM. PMID: 31075256; PMCID: PMC6867800.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma. J Clin Med. 2019 May 06; 8(5). Shah O'Brien P, Xi Y, Miller JR, Brownell AL, Zeng Q, Yoo GH, Garshott DM, O'Brien MB, Galinato AE, Cai P, Narula N, Callaghan MU, Kaufman RJ, Fribley AM. PMID: 31064122; PMCID: PMC6571807.
      View in: PubMed   Mentions: 20  
    41. Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes. Int J Mol Sci. 2019 Apr 05; 20(7). Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K. PMID: 30959808; PMCID: PMC6480217.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    42. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nat Commun. 2019 04 02; 10(1):1492. Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Kaufman RJ, Bosenberg M, Goding CR, Baaten B, Levesque MP, Dummer R, Brown K, Merlino G, Ruppin E, Flaherty K, Ramer-Tait A, Long T, Peterson SN, Bradley LM, Ronai ZA. PMID: 30940817; PMCID: PMC6445090.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    43. Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. Diabetes. 2019 06; 68(6):1287-1302. Li H, O'Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, Kaufman RJ, Monks TJ, Wang JM. PMID: 30885990; PMCID: PMC6610016.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    44. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019 03 06; 10(1):1084. Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina SK, Patel N, Savage NM, Sharma A, Kaufman RJ, Li H, Singh N. PMID: 30842412; PMCID: PMC6403283.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    45. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 09 20; 175(1):133-145.e15. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. PMID: 30220454; PMCID: PMC6159928.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    46. Biosynthesis, structure, and folding of the insulin precursor protein. Diabetes Obes Metab. 2018 09; 20 Suppl 2:28-50. Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P. PMID: 30230185; PMCID: PMC6463291.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    47. IRE1α nucleotide sequence cleavage specificity in the unfolded protein response. FEBS Lett. 2018 08; 592(15):2669. Poothong J, Sopha P, Kaufman RJ, Tirasophon W. PMID: 30168599.
      View in: PubMed   Mentions: 1     Fields:    
    48. High-content screen for modifiers of Niemann-Pick type C disease in patient cells. Hum Mol Genet. 2018 06 15; 27(12):2101-2112. Pugach EK, Feltes M, Kaufman RJ, Ory DS, Bang AG. PMID: 29659804; PMCID: PMC5985738.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    49. IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. Sci Signal. 2018 05 15; 11(530). Wang JM, Qiu Y, Yang Z, Kim H, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yang L, Zhang K. PMID: 29764990; PMCID: PMC6075656.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
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    79. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. ACS Med Chem Lett. 2014 Dec 11; 5(12):1278-1283. Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, Callaghan MU, Golden JE, Fribley AM, Kaufman RJ. PMID: 25530830; PMCID: PMC4266338.
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    81. Celastrol induces unfolded protein response-dependent cell death in head and neck cancer. Exp Cell Res. 2015 Jan 15; 330(2):412-422. Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, Kodali V, Kaufman RJ. PMID: 25139619; PMCID: PMC4280347.
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    83. Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling. J Biol Chem. 2014 Aug 29; 289(35):24417-27. Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT, Péterfy M. PMID: 25035425; PMCID: PMC4148868.
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    85. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS One. 2014; 9(7):e101643. Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. PMID: 24992504; PMCID: PMC4081565.
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    86. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nat Neurosci. 2014 Aug; 17(8):1073-82. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. PMID: 24974795; PMCID: PMC4340591.
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    90. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May; 10(5):e1004348. Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. PMID: 24809345; PMCID: PMC4014425.
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    95. Glycoprotein folding and quality-control mechanisms in protein-folding diseases. Dis Model Mech. 2014 Mar; 7(3):331-41. Ferris SP, Kodali VK, Kaufman RJ. PMID: 24609034; PMCID: PMC3944493.
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    96. Measurement of the unfolded protein response to investigate its role in adipogenesis and obesity. Methods Enzymol. 2014; 538:135-50. Han J, Kaufman RJ. PMID: 24529437.
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    97. eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies. Aging (Albany NY). 2013 Dec; 5(12):884-901. Rajesh K, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Ferbeyre G, Kaufman RJ, Koromilas AE. PMID: 24334569; PMCID: PMC3883705.
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    99. Molecular approaches for improved clotting factors for hemophilia. Blood. 2013 Nov 21; 122(22):3568-74. Kaufman RJ, Powell JS. PMID: 24065241; PMCID: PMC3837506.
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    116. Unfolded protein response. Curr Biol. 2012 Aug 21; 22(16):R622-6. Cao SS, Kaufman RJ. PMID: 22917505.
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    117. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab. 2012 Aug 08; 16(2):265-73. Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F. PMID: 22883234; PMCID: PMC3418541.
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    118. The impact of the unfolded protein response on human disease. J Cell Biol. 2012 Jun 25; 197(7):857-67. Wang S, Kaufman RJ. PMID: 22733998; PMCID: PMC3384412.
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    119. RNA surveillance is required for endoplasmic reticulum homeostasis. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8079-84. Sakaki K, Yoshina S, Shen X, Han J, DeSantis MR, Xiong M, Mitani S, Kaufman RJ. PMID: 22562797; PMCID: PMC3361423.
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    120. Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem. 2012; 81:767-93. Back SH, Kaufman RJ. PMID: 22443930; PMCID: PMC3684428.
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    121. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology. 2012 Apr; 55(4):1070-82. Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K. PMID: 22095841; PMCID: PMC3319338.
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    122. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis. 2012 Sep; 18(9):1735-42. Cao SS, Song B, Kaufman RJ. PMID: 22275310; PMCID: PMC3751177.
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    123. A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation. Mol Cell Biol. 2012 Mar; 32(5):992-1003. Majumder M, Huang C, Snider MD, Komar AA, Tanaka J, Kaufman RJ, Krokowski D, Hatzoglou M. PMID: 22215619; PMCID: PMC3295193.
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    124. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. J Biol Chem. 2012 Mar 02; 287(10):7603-14. Dickhout JG, Carlisle RE, Jerome DE, Mohammed-Ali Z, Jiang H, Yang G, Mani S, Garg SK, Banerjee R, Kaufman RJ, Maclean KN, Wang R, Austin RC. PMID: 22215680; PMCID: PMC3293561.
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    125. Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop. J Thromb Haemost. 2012 Jan; 10(1):107-15. Selvaraj SR, Scheller AN, Miao HZ, Kaufman RJ, Pipe SW. PMID: 22044596; PMCID: PMC3290727.
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    126. Beta-cell failure, stress, and type 2 diabetes. N Engl J Med. 2011 Nov 17; 365(20):1931-3. Kaufman RJ. PMID: 22087686; PMCID: PMC3684425.
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    127. ER stress and its functional link to mitochondria: role in cell survival and death. Cold Spring Harb Perspect Biol. 2011 Sep 01; 3(9):a004424. Malhotra JD, Kaufman RJ. PMID: 21813400; PMCID: PMC3181038.
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    128. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. J Biomol Screen. 2011 Sep; 16(8):825-35. Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, Ron D, Sherman DH, Kaufman RJ. PMID: 21844328; PMCID: PMC3374590.
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    129. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin. Blood. 2011 Sep 22; 118(12):3384-91. Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D. PMID: 21795745; PMCID: PMC3179404.
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    130. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Mol Biol Cell. 2011 Sep; 22(17):2994-3009. Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA. PMID: 21737679; PMCID: PMC3164449.
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    131. Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice. Haematologica. 2011 Sep; 96(9):1261-8. Mielke N, Schwarzer R, Calkhoven CF, Kaufman RJ, Dörken B, Leutz A, Jundt F. PMID: 21565905; PMCID: PMC3166095.
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    132. iRhoms: ERADicating the messenger in growth control signaling. Dev Cell. 2011 Apr 19; 20(4):414-6. Cao SS, Kaufman RJ. PMID: 21497754; PMCID: PMC3408039.
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    134. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab. 2011 Feb 02; 13(2):160-9. Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. PMID: 21284983; PMCID: PMC3057411.
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    135. Large-scale analysis of UPR-mediated apoptosis in human cells. Methods Enzymol. 2011; 491:57-71. Fribley AM, Miller JR, Reist TE, Callaghan MU, Kaufman RJ. PMID: 21329794; PMCID: PMC3390927.
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    136. Endoplasmic reticulum stress in liver disease. J Hepatol. 2011 Apr; 54(4):795-809. Malhi H, Kaufman RJ. PMID: 21145844; PMCID: PMC3375108.
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    137. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes Obes Metab. 2010 Oct; 12 Suppl 2:99-107. Kaufman RJ, Back SH, Song B, Han J, Hassler J. PMID: 21029306; PMCID: PMC3127455.
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    138. Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell. 2010 Sep 15; 21(18):3220-31. Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE. PMID: 20660158; PMCID: PMC2938387.
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    139. Temporal regulation of Cat-1 (cationic amino acid transporter-1) gene transcription during endoplasmic reticulum stress. Biochem J. 2010 Jul 01; 429(1):215-24. Huang CC, Li Y, Lopez AB, Chiang CM, Kaufman RJ, Snider MD, Hatzoglou M. PMID: 20408811; PMCID: PMC3684439.
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    140. Domain compatibility in Ire1 kinase is critical for the unfolded protein response. FEBS Lett. 2010 Jul 16; 584(14):3203-8. Poothong J, Sopha P, Kaufman RJ, Tirasophon W. PMID: 20541549; PMCID: PMC3762510.
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    141. Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism. EMBO Mol Med. 2010 Jun; 2(6):189-92. Kaufman RJ, Cao S. PMID: 20533428; PMCID: PMC3042734.
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    142. The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin. J Cell Biol. 2010 May 31; 189(5):829-41. Pearse BR, Tamura T, Sunryd JC, Grabowski GA, Kaufman RJ, Hebert DN. PMID: 20498017; PMCID: PMC2878942.
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    143. Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe. 2010 May 20; 7(5):354-61. Schulz O, Pichlmair A, Rehwinkel J, Rogers NC, Scheuner D, Kato H, Takeuchi O, Akira S, Kaufman RJ, Reis e Sousa C. PMID: 20478537; PMCID: PMC2919169.
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    144. Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection. J Interferon Cytokine Res. 2010 Apr; 30(4):263-72. Minor RA, Limmon GV, Miller-DeGraff L, Dixon D, Andrews DM, Kaufman RJ, Imani F. PMID: 20038207; PMCID: PMC3781957.
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    145. eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress. J Biol Chem. 2010 May 28; 285(22):17098-111. Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan CL, Wang C, Zhu X, Jordan LE, Scheuner D, Kaufman RJ, Koromilas AE, Snider MD, Holcik M, Hatzoglou M. PMID: 20338999; PMCID: PMC2878040.
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    146. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal. 2010 Jan 26; 3(106):ra7. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. PMID: 20103773; PMCID: PMC2940714.
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    147. Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Sci Signal. 2009 Dec 22; 2(102):ra85. Mounir Z, Krishnamoorthy JL, Robertson GP, Scheuner D, Kaufman RJ, Georgescu MM, Koromilas AE. PMID: 20029030; PMCID: PMC3684442.
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    148. ER stress controls iron metabolism through induction of hepcidin. Science. 2009 Aug 14; 325(5942):877-80. Vecchi C, Montosi G, Zhang K, Lamberti I, Duncan SA, Kaufman RJ, Pietrangelo A. PMID: 19679815; PMCID: PMC2923557.
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    149. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab. 2009 Jul; 10(1):13-26. Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ. PMID: 19583950; PMCID: PMC2742645.
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    150. Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Mol Cell Biol. 2009 Aug; 29(15):4295-307. DuRose JB, Scheuner D, Kaufman RJ, Rothblum LI, Niwa M. PMID: 19470760; PMCID: PMC2715810.
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    151. ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J Cell Sci. 2009 May 15; 122(Pt 10):1626-36. Bommiasamy H, Back SH, Fagone P, Lee K, Meshinchi S, Vink E, Sriburi R, Frank M, Jackowski S, Kaufman RJ, Brewer JW. PMID: 19420237; PMCID: PMC2680102.
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    152. Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response. J Biol Chem. 2009 Jul 03; 284(27):18202-9. Davies MJ, Miranda E, Roussel BD, Kaufman RJ, Marciniak SJ, Lomas DA. PMID: 19423713; PMCID: PMC2709363.
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    153. Uncoupling stress granule assembly and translation initiation inhibition. Mol Biol Cell. 2009 Jun; 20(11):2673-83. Mokas S, Mills JR, Garreau C, Fournier MJ, Robert F, Arya P, Kaufman RJ, Pelletier J, Mazroui R. PMID: 19369421; PMCID: PMC2688547.
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    154. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1832-7. Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D. PMID: 19181853; PMCID: PMC2644123.
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    155. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1392-7. Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR, Perrin S, Feany MB, Horwich AL. PMID: 19171884; PMCID: PMC2631083.
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    156. Regulation of apoptosis by the unfolded protein response. Methods Mol Biol. 2009; 559:191-204. Fribley A, Zhang K, Kaufman RJ. PMID: 19609758; PMCID: PMC3684430.
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    157. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell. 2008 Dec; 15(6):829-40. Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, Yau GD, Kaufman RJ. PMID: 19081072; PMCID: PMC2923556.
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    158. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18525-30. Malhotra JD, Miao H, Zhang K, Wolfson A, Pennathur S, Pipe SW, Kaufman RJ. PMID: 19011102; PMCID: PMC2587584.
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    159. Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. J Cell Sci. 2008 Nov 01; 121(Pt 21):3636-48. Kim J, Choi TG, Ding Y, Kim Y, Ha KS, Lee KH, Kang I, Ha J, Kaufman RJ, Lee J, Choe W, Kim SS. PMID: 18946027; PMCID: PMC2735721.
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    160. Is the ER stressed out in diabetic kidney disease? J Am Soc Nephrol. 2008 Nov; 19(11):2040-2. Brosius FC, Kaufman RJ. PMID: 18842986.
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    161. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 2008 Oct; 48(4):1242-50. Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA. PMID: 18704925; PMCID: PMC2717709.
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    162. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest. 2008 Oct; 118(10):3378-89. Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. PMID: 18776938; PMCID: PMC2528909.
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    163. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. J Biochem. 2008 Oct; 144(4):477-86. Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K. PMID: 18664523; PMCID: PMC2755579.
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    164. From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008 Jul 24; 454(7203):455-62. Zhang K, Kaufman RJ. PMID: 18650916; PMCID: PMC2727659.
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    165. Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. EMBO J. 2008 Aug 06; 27(15):2043-54. Farhan H, Weiss M, Tani K, Kaufman RJ, Hauri HP. PMID: 18650939; PMCID: PMC2516884.
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    166. Regulation of ER stress-induced macroautophagy by protein kinase C. Autophagy. 2008 Aug; 4(6):841-3. Sakaki K, Kaufman RJ. PMID: 18670192; PMCID: PMC2770887.
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    167. Novel function of PERK as a mediator of force-induced apoptosis. J Biol Chem. 2008 Aug 22; 283(34):23462-72. Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA. PMID: 18550523; PMCID: PMC2517009.
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    168. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev. 2008 May; 29(3):317-33. Scheuner D, Kaufman RJ. PMID: 18436705; PMCID: PMC2528859.
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    169. Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem. 2008 May 30; 283(22):15370-80. Sakaki K, Wu J, Kaufman RJ. PMID: 18356160; PMCID: PMC2397484.
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    170. MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. J Biol Chem. 2008 Apr 18; 283(16):10848-57. Thiaville MM, Pan YX, Gjymishka A, Zhong C, Kaufman RJ, Kilberg MS. PMID: 18287093; PMCID: PMC2447663.
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    171. An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation. RNA. 2008 Mar; 14(3):593-602. Zeenko VV, Wang C, Majumder M, Komar AA, Snider MD, Merrick WC, Kaufman RJ, Hatzoglou M. PMID: 18230759; PMCID: PMC2248251.
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    172. Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo. Methods Enzymol. 2008; 442:395-419. Zhang K, Kaufman RJ. PMID: 18662581; PMCID: PMC2865177.
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    173. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal. 2007 Dec; 9(12):2277-93. Malhotra JD, Kaufman RJ. PMID: 17979528.
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    174. That which does not kill me makes me stronger: adapting to chronic ER stress. Trends Biochem Sci. 2007 Oct; 32(10):469-76. Rutkowski DT, Kaufman RJ. PMID: 17920280.
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    175. The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol. 2007 Dec; 18(6):716-31. Malhotra JD, Kaufman RJ. PMID: 18023214; PMCID: PMC2706143.
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    177. Substrate-specific requirements for UGT1-dependent release from calnexin. Mol Cell. 2007 Jul 20; 27(2):238-249. Soldà T, Galli C, Kaufman RJ, Molinari M. PMID: 17643373.
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    178. IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. Cancer Res. 2007 Jul 15; 67(14):6700-7. Drogat B, Auguste P, Nguyen DT, Bouchecareilh M, Pineau R, Nalbantoglu J, Kaufman RJ, Chevet E, Bikfalvi A, Moenner M. PMID: 17638880.
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    179. The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell. 2007 Sep; 18(9):3681-91. Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. PMID: 17567950; PMCID: PMC1951758.
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    180. Regulation of ERGIC-53 gene transcription in response to endoplasmic reticulum stress. J Biol Chem. 2007 Aug 03; 282(31):22499-512. Renna M, Caporaso MG, Bonatti S, Kaufman RJ, Remondelli P. PMID: 17535801.
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    181. Inhibition of the ubiquitin-proteasome system induces stress granule formation. Mol Biol Cell. 2007 Jul; 18(7):2603-18. Mazroui R, Di Marco S, Kaufman RJ, Gallouzi IE. PMID: 17475769; PMCID: PMC1924830.
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    182. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 2007 Apr 06; 129(1):195-206. Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjevic K, Lacaille JC, Nader K, Sonenberg N. PMID: 17418795; PMCID: PMC4149214.
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    183. Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation. EMBO Rep. 2007 May; 8(5):483-9. Nagasawa K, Higashi T, Hosokawa N, Kaufman RJ, Nagata K. PMID: 17380188; PMCID: PMC1866203.
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    184. Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 2007 Jun 15; 109(12):5270-5. Zhu A, Sun H, Raymond RM, Furie BC, Furie B, Bronstein M, Kaufman RJ, Westrick R, Ginsburg D. PMID: 17327402; PMCID: PMC1890832.
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    185. Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux. J Cell Biol. 2007 Feb 26; 176(5):605-16. Shang J, Gao N, Kaufman RJ, Ron D, Harding HP, Lehrman MA. PMID: 17325203; PMCID: PMC2064019.
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    262. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002 Feb 15; 16(4):452-66. Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ. PMID: 11850408; PMCID: PMC155339.
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    263. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell. 2001 Dec 28; 107(7):893-903. Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ. PMID: 11779465.
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    264. Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):190-5. Tallóczy Z, Jiang W, Virgin HW, Leib DA, Scheuner D, Kaufman RJ, Eskelinen EL, Levine B. PMID: 11756670; PMCID: PMC117537.
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    265. New ways of initiating translation in eukaryotes. Mol Cell Biol. 2001 Dec; 21(23):8238-46. Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. PMID: 11710333; PMCID: PMC99989.
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    266. Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem. 2001 Sep 21; 276(38):35867-74. Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S. PMID: 11447214.
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    267. Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis. Am J Pathol. 2001 Jul; 159(1):273-83. Scarim AL, Arnush M, Blair LA, Concepcion J, Heitmeier MR, Scheuner D, Kaufman RJ, Ryerse J, Buller RM, Corbett JA. PMID: 11438474; PMCID: PMC1850419.
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    268. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell. 2001 Jun; 7(6):1165-76. Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. PMID: 11430820.
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    269. Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa. Blood. 2001 Feb 01; 97(3):685-91. Pipe SW, Saenko EL, Eickhorst AN, Kemball-Cook G, Kaufman RJ. PMID: 11157485.
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    270. The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast. Genes Dev. 2000 Dec 01; 14(23):2962-75. Schröder M, Chang JS, Kaufman RJ. PMID: 11114886; PMCID: PMC317105.
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    271. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev. 2000 Nov 01; 14(21):2725-36. Tirasophon W, Lee K, Callaghan B, Welihinda A, Kaufman RJ. PMID: 11069889; PMCID: PMC317029.
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    272. Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of eIF2B. Biochemistry. 2000 Oct 24; 39(42):12929-38. Sudhakar A, Ramachandran A, Ghosh S, Hasnain SE, Kaufman RJ, Ramaiah KV. PMID: 11041858.
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    273. Overview of vector design for mammalian gene expression. Mol Biotechnol. 2000 Oct; 16(2):151-60. Kaufman RJ. PMID: 11131974.
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    274. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J Biol Chem. 2000 Sep 01; 275(35):27013-20. Wang Y, Shen J, Arenzana N, Tirasophon W, Kaufman RJ, Prywes R. PMID: 10856300.
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    275. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem. 2000 Aug 11; 275(32):24881-5. Liu CY, Schröder M, Kaufman RJ. PMID: 10835430.
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    276. Potential role of PKR in double-stranded RNA-induced macrophage activation. EMBO J. 2000 Jul 17; 19(14):3630-8. Maggi LB, Heitmeier MR, Scheuner D, Kaufman RJ, Buller RM, Corbett JA. PMID: 10899117; PMCID: PMC313973.
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    277. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. Biochemistry. 2000 Mar 07; 39(9):2149-63. Arnold SM, Fessler LI, Fessler JH, Kaufman RJ. PMID: 10694380.
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    278. ATP-dependent dissociation of non-disulfide-linked aggregates of coagulation factor VIII is a rate-limiting step for secretion. Biochemistry. 2000 Feb 29; 39(8):1973-81. Tagliavacca L, Wang Q, Kaufman RJ. PMID: 10684647.
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    279. The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo. J Biol Chem. 2000 Feb 04; 275(5):3377-81. Welihinda AA, Tirasophon W, Kaufman RJ. PMID: 10652329.
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    280. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell. 1999 Dec 23; 99(7):691-702. Niwa M, Sidrauski C, Kaufman RJ, Walter P. PMID: 10619423.
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    281. Serine 48 in initiation factor 2 alpha (eIF2 alpha) is required for high-affinity interaction between eIF2 alpha(P) and eIF2B. Biochemistry. 1999 Nov 16; 38(46):15398-405. Sudhakar A, Krishnamoorthy T, Jain A, Chatterjee U, Hasnain SE, Kaufman RJ, Ramaiah KV. PMID: 10563826.
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    282. Mannose-dependent endoplasmic reticulum (ER)-Golgi intermediate compartment-53-mediated ER to Golgi trafficking of coagulation factors V and VIII. J Biol Chem. 1999 Nov 12; 274(46):32539-42. Moussalli M, Pipe SW, Hauri HP, Nichols WC, Ginsburg D, Kaufman RJ. PMID: 10551804.
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    283. Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1. J Biol Chem. 1999 Oct 22; 274(43):30402-9. Foti DM, Welihinda A, Kaufman RJ, Lee AS. PMID: 10521417.
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    284. Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):11693-5. Kaufman RJ. PMID: 10518510; PMCID: PMC33789.
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    285. Advances toward gene therapy for hemophilia at the millennium. Hum Gene Ther. 1999 Sep 01; 10(13):2091-107. Kaufman RJ. PMID: 10498242.
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    286. Correction of genetic disease by making sense from nonsense. J Clin Invest. 1999 Aug; 104(4):367-8. Kaufman RJ. PMID: 10449426; PMCID: PMC408532.
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    287. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 1999 May 15; 13(10):1211-33. Kaufman RJ. PMID: 10346810.
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    288. Eukaryotic initiation factor 2alpha kinase and phosphatase activity during postischemic brain reperfusion. Exp Neurol. 1999 Feb; 155(2):221-7. DeGracia DJ, Adamczyk S, Folbe AJ, Konkoly LL, Pittman JE, Neumar RW, Sullivan JM, Scheuner D, Kaufman RJ, White BC, Krause GS. PMID: 10072297.
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    289. Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. Mol Cell Biol. 1999 Feb; 19(2):1116-25. Kumar KU, Srivastava SP, Kaufman RJ. PMID: 9891046; PMCID: PMC116041.
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    290. Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation. Eur J Biochem. 1999 Feb; 260(1):64-75. Heeb MJ, Rehemtulla A, Moussalli M, Kojima Y, Kaufman RJ. PMID: 10091585.
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    291. Molecular chaperones and the heat shock response. Sponsored by Cold Spring Harbor Laboratory, 6-10 May 1998. Biochim Biophys Acta. 1999 Jan 29; 1423(1):R13-27. Kaufman RJ. PMID: 9989210.
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    292. Mild hemophilia A caused by increased rate of factor VIII A2 subunit dissociation: evidence for nonproteolytic inactivation of factor VIIIa in vivo. Blood. 1999 Jan 01; 93(1):176-83. Pipe SW, Eickhorst AN, McKinley SH, Saenko EL, Kaufman RJ. PMID: 9864159.
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    293. von Willebrand factor elevates plasma factor VIII without induction of factor VIII messenger RNA in the liver. Blood. 1999 Jan 01; 93(1):193-7. Kaufman RJ, Dorner AJ, Fass DN. PMID: 9864161.
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    294. The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expr. 1999; 7(4-6):293-300. Welihinda AA, Tirasophon W, Kaufman RJ. PMID: 10440230; PMCID: PMC6174664.
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    295. Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR). Biochemistry. 1998 Sep 29; 37(39):13816-26. Wu S, Kumar KU, Kaufman RJ. PMID: 9753471.
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    296. Can we improve on nature? "Super molecules" of factor VIII. Haemophilia. 1998 Jul; 4(4):370-9. Kaufman RJ, Pipe SW. PMID: 9873757.
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    297. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 1998 Jun 15; 12(12):1812-24. Tirasophon W, Welihinda AA, Kaufman RJ. PMID: 9637683; PMCID: PMC316900.
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    298. Post-translational modifications required for coagulation factor secretion and function. Thromb Haemost. 1998 Jun; 79(6):1068-79. Kaufman RJ. PMID: 9657426.
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    299. Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell. 1998 Apr 03; 93(1):61-70. Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli MJ, Hauri HP, Ciavarella N, Kaufman RJ, Ginsburg D. PMID: 9546392.
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    300. Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin. J Biol Chem. 1998 Apr 03; 273(14):8537-44. Pipe SW, Morris JA, Shah J, Kaufman RJ. PMID: 9525969.
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    301. Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Mol Cell Biol. 1998 Apr; 18(4):1967-77. Welihinda AA, Tirasophon W, Green SR, Kaufman RJ. PMID: 9528768; PMCID: PMC121426.
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    302. Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test. Thromb Haemost. 1998 Mar; 79(3):557-63. Amano K, Michnick DA, Moussalli M, Kaufman RJ. PMID: 9531040.
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    303. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. J Biol Chem. 1998 Jan 23; 273(4):2416-23. Srivastava SP, Kumar KU, Kaufman RJ. PMID: 9442091.
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    304. Biosynthesis, assembly and secretion of coagulation factor VIII. Blood Coagul Fibrinolysis. 1997 Dec; 8 Suppl 2:S3-14. Kaufman RJ, Pipe SW, Tagliavacca L, Swaroop M, Moussalli M. PMID: 9607108.
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    305. Characterization of a genetically engineered inactivation-resistant coagulation factor VIIIa. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):11851-6. Pipe SW, Kaufman RJ. PMID: 9342326; PMCID: PMC23634.
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    306. Identification and functional requirement of Cu(I) and its ligands within coagulation factor VIII. J Biol Chem. 1997 Oct 24; 272(43):27428-34. Tagliavacca L, Moon N, Dunham WR, Kaufman RJ. PMID: 9341195.
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    307. Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII. J Biol Chem. 1997 Sep 26; 272(39):24121-4. Swaroop M, Moussalli M, Pipe SW, Kaufman RJ. PMID: 9305856.
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    308. Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4289-94. Welihinda AA, Tirasophon W, Green SR, Kaufman RJ. PMID: 9113982; PMCID: PMC20715.
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    309. DNA transfection to study translational control in mammalian cells. Methods. 1997 Apr; 11(4):361-70. Kaufman RJ. PMID: 9126551.
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    310. Linkage of combined factors V and VIII deficiency to chromosome 18q by homozygosity mapping. J Clin Invest. 1997 Feb 15; 99(4):596-601. Nichols WC, Seligsohn U, Zivelin A, Terry VH, Arnold ND, Siemieniak DR, Kaufman RJ, Ginsburg D. PMID: 9045860; PMCID: PMC507840.
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    311. Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins. J Biol Chem. 1997 Feb 14; 272(7):4327-34. Morris JA, Dorner AJ, Edwards CA, Hendershot LM, Kaufman RJ. PMID: 9020152.
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    312. A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR. J Biol Chem. 1997 Jan 10; 272(2):1291-6. Wu S, Kaufman RJ. PMID: 8995434.
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    313. Overview of vector design for mammalian gene expression. Methods Mol Biol. 1997; 62:287-300. Kaufman RJ. PMID: 9108528.
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    314. Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins. J Biol Chem. 1996 Oct 11; 271(41):25671-6. Pipe SW, Kaufman RJ. PMID: 8810344.
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    315. Inhibition of translational initiation by activators of the glucose-regulated stress protein and heat shock protein stress response systems. Role of the interferon-inducible double-stranded RNA-activated eukaryotic initiation factor 2alpha kinase. J Biol Chem. 1996 Oct 04; 271(40):24995-5002. Brostrom CO, Prostko CR, Kaufman RJ, Brostrom MA. PMID: 8798781.
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    316. Moderation of hemophilia A phenotype by the factor V R506Q mutation. Blood. 1996 Aug 15; 88(4):1183-7. Nichols WC, Amano K, Cacheris PM, Figueiredo MS, Michaelides K, Schwaab R, Hoyer L, Kaufman RJ, Ginsburg D. PMID: 8695835.
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    317. The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation. J Biol Chem. 1996 Jul 26; 271(30):18181-7. Welihinda AA, Kaufman RJ. PMID: 8663458.
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    318. A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells. Biochemistry. 1996 Jun 25; 35(25):8275-80. Wu S, Rehemtulla A, Gupta NK, Kaufman RJ. PMID: 8679583.
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    319. Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR). J Biol Chem. 1996 Jan 19; 271(3):1756-63. Wu S, Kaufman RJ. PMID: 8576179.
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    320. Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis. J Biol Chem. 1995 Jul 14; 270(28):16619-24. Srivastava SP, Davies MV, Kaufman RJ. PMID: 7622470.
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    321. A 110-amino acid region within the A1-domain of coagulation factor VIII inhibits secretion from mammalian cells. J Biol Chem. 1995 Apr 28; 270(17):10297-303. Marquette KA, Pittman DD, Kaufman RJ. PMID: 7730335.
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    322. Control of gene expression at the level of translation initiation. Curr Opin Biotechnol. 1994 Oct; 5(5):550-7. Kaufman RJ. PMID: 7765472.
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    323. Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells. Biochemistry. 1994 Aug 23; 33(33):9813-9. Kaufman RJ, Swaroop M, Murtha-Riel P. PMID: 8060988.
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    324. Expression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation. Mol Cell Biol. 1994 Jul; 14(7):4546-53. Ramaiah KV, Davies MV, Chen JJ, Kaufman RJ. PMID: 8007958; PMCID: PMC358826.
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    325. The levels of endoplasmic reticulum proteins and ATP affect folding and secretion of selective proteins. Biologicals. 1994 Jun; 22(2):103-12. Dorner AJ, Kaufman RJ. PMID: 7917226.
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    326. TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4713-7. Park H, Davies MV, Langland JO, Chang HW, Nam YS, Tartaglia J, Paoletti E, Jacobs BL, Kaufman RJ, Venkatesan S. PMID: 7515177; PMCID: PMC43858.
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    327. Expression of a phosphorylation-resistant eukaryotic initiation factor 2 alpha-subunit mitigates heat shock inhibition of protein synthesis. J Biol Chem. 1993 Jun 15; 268(17):12946-51. Murtha-Riel P, Davies MV, Scherer BJ, Choi SY, Hershey JW, Kaufman RJ. PMID: 8509427.
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    328. Characterization of wild-type and Ser53 mutant eukaryotic initiation factor 4E overexpression in mammalian cells. J Biol Chem. 1993 Jun 05; 268(16):11902-9. Kaufman RJ, Murtha-Riel P, Pittman DD, Davies MV. PMID: 8505316.
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    329. PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon. J Interferon Res. 1993 Jun; 13(3):241. Clemens MJ, Hershey JW, Hovanessian AC, Jacobs BC, Katze MG, Kaufman RJ, Lengyel P, Samuel CE, Sen GC, Williams BR. PMID: 7690057.
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    330. The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms. J Virol. 1993 Mar; 67(3):1688-92. Davies MV, Chang HW, Jacobs BL, Kaufman RJ. PMID: 8094759; PMCID: PMC237544.
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    331. The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2. J Virol. 1992 Apr; 66(4):1943-50. Davies MV, Elroy-Stein O, Jagus R, Moss B, Kaufman RJ. PMID: 1347793; PMCID: PMC288982.
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    332. Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2. J Biol Chem. 1992 Jan 05; 267(1):286-93. Choi SY, Scherer BJ, Schnier J, Davies MV, Kaufman RJ, Hershey JW. PMID: 1346129.
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    333. An internal ribosome binding site can be used to select for homologous recombinants at an immunoglobulin heavy-chain locus. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8006-10. Wood CR, Morris GE, Alderman EM, Fouser L, Kaufman RJ. PMID: 1654552; PMCID: PMC52434.
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    334. The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation. J Biol Chem. 1991 Aug 05; 266(22):14714-20. Davies MV, Pelletier J, Meerovitch K, Sonenberg N, Kaufman RJ. PMID: 1713590.
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    335. The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion. J Biol Chem. 1990 Dec 15; 265(35):22029-34. Dorner AJ, Wasley LC, Raney P, Haugejorden S, Green M, Kaufman RJ. PMID: 2254345.
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    336. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. Mol Cell Biol. 1990 Dec; 10(12):6709-17. Lum LS, Sultzman LA, Kaufman RJ, Linzer DI, Wu BJ. PMID: 2247079; PMCID: PMC362949.
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    337. Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9163-7. Davies MV, Furtado M, Hershey JW, Thimmappaya B, Kaufman RJ. PMID: 2594757; PMCID: PMC298454.
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    338. Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells. Mol Cell Biol. 1989 Mar; 9(3):1233-42. Kaufman RJ, Wasley LC, Davies MV, Wise RJ, Israel DI, Dorner AJ. PMID: 2498645; PMCID: PMC362714.
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    339. The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Mol Cell Biol. 1989 Mar; 9(3):946-58. Kaufman RJ, Davies MV, Pathak VK, Hershey JW. PMID: 2657393; PMCID: PMC362683.
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    340. Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells. Mol Cell Biol. 1988 Oct; 8(10):4063-70. Dorner AJ, Krane MG, Kaufman RJ. PMID: 2460739; PMCID: PMC365475.
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    341. The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers. Cell. 1988 Jan 29; 52(2):229-36. Wise RJ, Pittman DD, Handin RI, Kaufman RJ, Orkin SH. PMID: 3124962.
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    342. Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells. Mol Cell Biol. 1987 Apr; 7(4):1568-71. Kaufman RJ, Murtha P. PMID: 3600637; PMCID: PMC365249.
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    343. Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells. Mol Cell Biol. 1985 Jul; 5(7):1750-9. Kaufman RJ, Wasley LC, Spiliotes AJ, Gossels SD, Latt SA, Larsen GR, Kay RM. PMID: 4040603; PMCID: PMC367294.
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    344. Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity. Mol Cell Biol. 1984 Oct; 4(10):1970-7. Kingston RE, Kaufman RJ, Sharp PA. PMID: 6095034; PMCID: PMC369013.
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    345. Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes. Mol Cell Biol. 1983 Sep; 3(9):1598-608. Kaufman RJ, Sharp PA. PMID: 6138708; PMCID: PMC370013.
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    346. Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences. Mol Cell Biol. 1983 Apr; 3(4):699-711. Kaufman RJ, Sharp PA, Latt SA. PMID: 6855772; PMCID: PMC368586.
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    347. Construction and use of a dominant, selectable marker: a Harvey sarcoma virus-dihydrofolate reductase chimera. Mol Cell Biol. 1983 Jan; 3(1):32-43. Murray MJ, Kaufman RJ, Latt SA, Weinberg RA. PMID: 6298606; PMCID: PMC368500.
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    348. Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression. Mol Cell Biol. 1982 Nov; 2(11):1304-19. Kaufman RJ, Sharp PA. PMID: 6131378; PMCID: PMC369935.
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    349. Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line. Mol Cell Biol. 1981 Dec; 1(12):1069-76. Kaufman RJ, Schimke RT. PMID: 7346712; PMCID: PMC369733.
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    350. Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines. Mol Cell Biol. 1981 Dec; 1(12):1084-93. Kaufman RJ, Brown PC, Schimke RT. PMID: 7346713; PMCID: PMC369735.
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    351. Structure and genomic organization of the mouse dihydrofolate reductase gene. Cell. 1980 Feb; 19(2):355-64. Nunberg JH, Kaufman RJ, Chang AC, Cohen SN, Schimke RT. PMID: 6244105.
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