Randal Kaufman

Title(s)Adjunct Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    A Novel Role for the UPR Component, ATF6 in AD-associated Neuroprotective Pathways
    NIH R01AG062190Mar 1, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Mechanism of ER Protein Misfolding-Induced Mitochondrial Dysfunction
    NIH R01DK113171Sep 18, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Modifiers of Proinsulin Influence T2D Susceptibility
    NIH R24DK110973Sep 12, 2016 - Jun 30, 2020
    Role: Principal Investigator
    ER stress and UPR in non-alcoholic steatohepatitis and hepatocellular carcinoma
    NIH R01CA198103May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Homeostatic Role of IRE1a-XBP1-PDI1 in Hepatic Lipid Metabolism
    NIH R01DK103185Apr 1, 2015 - Dec 31, 2020
    Role: Principal Investigator
    eIF2a phosphorylation as a novel druggable target in CRPC
    NIH R21CA190588Jan 5, 2015 - Dec 31, 2016
    Role: Co-Principal Investigator
    Alteration in protein interactions with proinsulin and insulin in type 2 diabetes
    NIH R24DK093074Sep 1, 2011 - Feb 28, 2013
    Role: Principal Investigator
    Regulation of ER stress-induced cell death
    NIH R01DK088227Sep 1, 2010 - May 31, 2015
    Role: Principal Investigator
    HTP chemical genomic screens to identify positive regulators of the Unfolded Prot
    NIH R03MH089782Sep 30, 2009 - May 31, 2011
    Role: Principal Investigator
    High Throughput Chemical Genomics to Identify Novel Inhibitors of CHOP
    NIH R03MH084182Jun 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Unfolded proteins in the Endoplasmic Reticulum to Disease
    NIH R13DK079785Jul 15, 2007 - Jun 30, 2008
    Role: Principal Investigator
    Conformational Diseases of the Secretory Pathway
    NIH R13DK063935Jan 15, 2003 - Dec 31, 2003
    Role: Principal Investigator
    Role of the Unfolded Protein Response in Beta Cell
    NIH R37DK042394Jan 1, 1998 - Aug 31, 2017
    Role: Principal Investigator
    Unfolded Protein Response in Glucose Homeostasis
    NIH R01DK042394Jan 1, 1998 - Jun 30, 2007
    Role: Principal Investigator
    TRANSLATIONAL CONTROL IN REGULATION OF APOPTOSIS
    NIH R01AI042394Jan 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    Regulation of Factor FVIII Secretion
    NIH R01HL052173Aug 1, 1995 - Sep 30, 2015
    Role: Principal Investigator
    ADENOVIRUS--MEDIATED DELIVERY OF NOVEL FACTOR VIII
    NIH R01HL053777Sep 30, 1994 - Aug 31, 2002
    Role: Principal Investigator
    GENETIC ENGINEERING OF AN IMPROVED FACTOR VIII PRODUCT
    NIH R44HL035946Mar 1, 1988 - Feb 28, 1990
    Role: Principal Investigator
    PRODUCTION OF MONOCLONAL ANTIBODIES IN TRANSGENIC MICE
    NIH R44GM037329Jul 1, 1986 - Aug 31, 1990
    Role: Principal Investigator
    PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES
    NIH R43GM037329Jul 1, 1986 - Dec 31, 1986
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model. Sci Rep. 2021 Aug 11; 11(1):16356. Lee EJ, Chan P, Chea L, Kim K, Kaufman RJ, Lin JH. PMID: 34381136.
      View in: PubMed   Mentions:    Fields:    
    2. Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice. Sci Transl Med. 2021 07 28; 13(604). Yong J, Parekh VS, Reilly SM, Nayak J, Chen Z, Lebeaupin C, Jang I, Zhang J, Prakash TP, Sun H, Murray S, Guo S, Ayala JE, Satin LS, Saltiel AR, Kaufman RJ. PMID: 34321322.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus. Nat Rev Endocrinol. 2021 08; 17(8):455-467. Yong J, Johnson JD, Arvan P, Han J, Kaufman RJ. PMID: 34163039.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy. J Neurosci. 2021 May 19; 41(20):4536-4548. Sidoli M, Reed CB, Scapin C, Paez P, Cavener DR, Kaufman RJ, D'Antonio M, Feltri ML, Wrabetz L. PMID: 33879538.
      View in: PubMed   Mentions:    Fields:    
    5. Normal and defective pathways in biogenesis and maintenance of the insulin storage pool. J Clin Invest. 2021 01 19; 131(2). Liu M, Huang Y, Xu X, Li X, Alam M, Arunagiri A, Haataja L, Ding L, Wang S, Itkin-Ansari P, Kaufman RJ, Tsai B, Qi L, Arvan P. PMID: 33463547.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum. Prog Mol Subcell Biol. 2021; 59:115-143. Poothong J, Jang I, Kaufman RJ. PMID: 34050864.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nat Neurosci. 2021 02; 24(2):204-213. Kalish BT, Kim E, Finander B, Duffy EE, Kim H, Gilman CK, Yim YS, Tong L, Kaufman RJ, Griffith EC, Choi GB, Greenberg ME, Huh JR. PMID: 33361822.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. eIF2α controls memory consolidation via excitatory and somatostatin neurons. Nature. 2020 10; 586(7829):412-416. Sharma V, Sood R, Khlaifia A, Eslamizade MJ, Hung TY, Lou D, Asgarihafshejani A, Lalzar M, Kiniry SJ, Stokes MP, Cohen N, Nelson AJ, Abell K, Possemato AP, Gal-Ben-Ari S, Truong VT, Wang P, Yiannakas A, Saffarzadeh F, Cuello AC, Nader K, Kaufman RJ, Costa-Mattioli M, Baranov PV, Quintana A, Sanz E, Khoutorsky A, Lacaille JC, Rosenblum K, Sonenberg N. PMID: 33029011.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. Phosphorylation of eIF2α Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR. J Neurosci. 2020 10 14; 40(42):8174-8187. Scapin C, Ferri C, Pettinato E, Bianchi F, Del Carro U, Feltri ML, Kaufman RJ, Wrabetz L, D'Antonio M. PMID: 32973043.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology. 2020 10; 159(4):1487-1503.e17. Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H. PMID: 32574624.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    11. Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. Diabetes. 2020 08; 69(8):1723-1734. Tran DT, Pottekat A, Mir SA, Loguercio S, Jang I, Campos AR, Scully KM, Lahmy R, Liu M, Arvan P, Balch WE, Kaufman RJ, Itkin-Ansari P. PMID: 32457219.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Mechanisms, regulation and functions of the unfolded protein response. Nat Rev Mol Cell Biol. 2020 08; 21(8):421-438. Hetz C, Zhang K, Kaufman RJ. PMID: 32457508.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    13. Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum. Blood. 2020 05 21; 135(21):1899-1911. Poothong J, Pottekat A, Siirin M, Campos AR, Paton AW, Paton JC, Lagunas-Acosta J, Chen Z, Swift M, Volkmann N, Hanein D, Yong J, Kaufman RJ. PMID: 32128578.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth. Diabetes. 2020 05; 69(5):954-964. Sun J, Xiong Y, Li X, Haataja L, Chen W, Mir SA, Lv L, Madley R, Larkin D, Anjum A, Dhayalan B, Rege N, Wickramasinghe NP, Weiss MA, Itkin-Ansari P, Kaufman RJ, Ostrov DA, Arvan P, Liu M. PMID: 32139596.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts. Int J Mol Sci. 2020 Feb 18; 21(4). Stauffer WT, Blackwood EA, Azizi K, Kaufman RJ, Glembotski CC. PMID: 32085622.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. The Impact of the ER Unfolded Protein Response on Cancer Initiation and Progression: Therapeutic Implications. Adv Exp Med Biol. 2020; 1243:113-131. Lebeaupin C, Yong J, Kaufman RJ. PMID: 32297215.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    17. Development of a Reporter System Monitoring Regulated Intramembrane Proteolysis of the Transmembrane bZIP Transcription Factor ATF6α. Mol Cells. 2019 Nov 30; 42(11):783-793. Kim JI, Kaufman RJ, Back SH, Moon JY. PMID: 31707777.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. Neuron. 2019 11 20; 104(4):724-735.e6. Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R. PMID: 31522764.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    19. Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2. Elife. 2019 09 09; 8. Yong J, Bischof H, Burgstaller S, Siirin M, Murphy A, Malli R, Kaufman RJ. PMID: 31498082.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Proinsulin misfolding is an early event in the progression to type 2 diabetes. Elife. 2019 06 11; 8. Arunagiri A, Haataja L, Pottekat A, Pamenan F, Kim S, Zeltser LM, Paton AW, Paton JC, Tsai B, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. PMID: 31184302.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    21. PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity. Elife. 2019 06 11; 8. Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ. PMID: 31184304.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    22. Targeting the unfolded protein response in head and neck and oral cavity cancers. Exp Cell Res. 2019 09 01; 382(1):111386. Cole DW, Svider PF, Shenouda KG, Lee PB, Yoo NG, McLeod TM, Mutchnick SA, Yoo GH, Kaufman RJ, Callaghan MU, Fribley AM. PMID: 31075256.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma. J Clin Med. 2019 May 06; 8(5). Shah O'Brien P, Xi Y, Miller JR, Brownell AL, Zeng Q, Yoo GH, Garshott DM, O'Brien MB, Galinato AE, Cai P, Narula N, Callaghan MU, Kaufman RJ, Fribley AM. PMID: 31064122.
      View in: PubMed   Mentions:
    24. Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes. Int J Mol Sci. 2019 Apr 05; 20(7). Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K. PMID: 30959808.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nat Commun. 2019 04 02; 10(1):1492. Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Kaufman RJ, Bosenberg M, Goding CR, Baaten B, Levesque MP, Dummer R, Brown K, Merlino G, Ruppin E, Flaherty K, Ramer-Tait A, Long T, Peterson SN, Bradley LM, Ronai ZA. PMID: 30940817.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    26. Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. Diabetes. 2019 06; 68(6):1287-1302. Li H, O'Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, Kaufman RJ, Monks TJ, Wang JM. PMID: 30885990.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019 03 06; 10(1):1084. Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina SK, Patel N, Savage NM, Sharma A, Kaufman RJ, Li H, Singh N. PMID: 30842412.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    28. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 09 20; 175(1):133-145.e15. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. PMID: 30220454.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    29. Biosynthesis, structure, and folding of the insulin precursor protein. Diabetes Obes Metab. 2018 09; 20 Suppl 2:28-50. Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P. PMID: 30230185.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    30. IRE1α nucleotide sequence cleavage specificity in the unfolded protein response. FEBS Lett. 2018 08; 592(15):2669. Poothong J, Sopha P, Kaufman RJ, Tirasophon W. PMID: 30168599.
      View in: PubMed   Mentions:    Fields:    
    31. High-content screen for modifiers of Niemann-Pick type C disease in patient cells. Hum Mol Genet. 2018 06 15; 27(12):2101-2112. Pugach EK, Feltes M, Kaufman RJ, Ory DS, Bang AG. PMID: 29659804.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    32. IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. Sci Signal. 2018 05 15; 11(530). Wang JM, Qiu Y, Yang Z, Kim H, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yang L, Zhang K. PMID: 29764990.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    33. Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response. Curr Top Microbiol Immunol. 2018; 414:103-130. Chandrahas VK, Han J, Kaufman RJ. PMID: 28900680.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    34. HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency. Blood. 2018 01 25; 131(4):450-461. Zhang S, Macias-Garcia A, Velazquez J, Paltrinieri E, Kaufman RJ, Chen JJ. PMID: 29101239.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    35. eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. Nutr Metab (Lond). 2017; 14:48. Choi WG, Han J, Kim JH, Kim MJ, Park JW, Song B, Cha HJ, Choi HS, Chung HT, Lee IK, Park TS, Hatzoglou M, Choi HS, Yoo HJ, Kaufman RJ, Back SH. PMID: 28781602.
      View in: PubMed   Mentions:
    36. Physiological/pathological ramifications of transcription factors in the unfolded protein response. Genes Dev. 2017 07 15; 31(14):1417-1438. Han J, Kaufman RJ. PMID: 28860159.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    37. ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell Rep. 2017 05 30; 19(9):1794-1806. DeZwaan-McCabe D, Sheldon RD, Gorecki MC, Guo DF, Gansemer ER, Kaufman RJ, Rahmouni K, Gillum MP, Taylor EB, Teesch LM, Rutkowski DT. PMID: 28564599.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    38. Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response. Biosci Rep. 2017 04 30; 37(2). Poothong J, Tirasophon W, Kaufman RJ. PMID: 28093457.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    39. IRE1α nucleotide sequence cleavage specificity in the unfolded protein response. FEBS Lett. 2017 01; 591(2):406-414. Poothong J, Sopha P, Kaufman RJ, Tirasophon W. PMID: 28027394.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    40. Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia. Diabetes. 2017 03; 66(3):663-673. Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, Li X, Kaufman RJ, Yan J, Liu T, Williams KW. PMID: 28028078.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    41. Achromatopsia mutations target sequential steps of ATF6 activation. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):400-405. Chiang WC, Chan P, Wissinger B, Vincent A, Skorczyk-Werner A, Krawczynski MR, Kaufman RJ, Tsang SH, Héon E, Kohl S, Lin JH. PMID: 28028229.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    42. eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons. Elife. 2016 12 13; 5. Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjevic K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M. PMID: 27960077.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    43. ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. Circ Res. 2017 Mar 03; 120(5):862-875. Jin JK, Blackwood EA, Azizi K, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC. PMID: 27932512.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    44. Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. Sci Transl Med. 2016 10 26; 8(362):362ra144. Oubaha M, Miloudi K, Dejda A, Guber V, Mawambo G, Germain MA, Bourdel G, Popovic N, Rezende FA, Kaufman RJ, Mallette FA, Sapieha P. PMID: 27797960.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    45. Read-Split-Run: an improved bioinformatics pipeline for identification of genome-wide non-canonical spliced regions using RNA-Seq data. BMC Genomics. 2016 08 22; 17 Suppl 7:503. Bai Y, Kinne J, Donham B, Jiang F, Ding L, Hassler JR, Kaufman RJ. PMID: 27556805.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    46. The unfolded protein response in immunity and inflammation. Nat Rev Immunol. 2016 08; 16(8):469-84. Grootjans J, Kaser A, Kaufman RJ, Blumberg RS. PMID: 27346803.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    47. Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules. J Neurosci. 2016 05 25; 36(21):5891-903. Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH, Ferguson TA, Chen DF, Kaufman RJ, Hu Y. PMID: 27225776.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    48. The role of ER stress in lipid metabolism and lipotoxicity. J Lipid Res. 2016 08; 57(8):1329-38. Han J, Kaufman RJ. PMID: 27146479.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    49. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016 Mar 24; 531(7595):523-527. Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC, Li S, Sharma P, Kaufman RJ, Martinez J, Pulendran B. PMID: 26982722.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    50. Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature. 2016 Jan 21; 529(7586):326-35. Wang M, Kaufman RJ. PMID: 26791723.
      View in: PubMed   Mentions: 352     Fields:    Translation:HumansAnimalsCells
    51. When Less Is Better: ER Stress and Beta Cell Proliferation. Dev Cell. 2016 Jan 11; 36(1):4-6. Yong J, Itkin-Ansari P, Kaufman RJ. PMID: 26766438.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    52. The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells. PLoS Biol. 2015 10; 13(10):e1002277. Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates JR, Itkin-Ansari P, Volkmann N, Kaufman RJ. PMID: 26469762.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    53. Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis. ACS Med Chem Lett. 2015 Nov 12; 6(11):1122-7. Sidhu A, Miller JR, Tripathi A, Garshott DM, Brownell AL, Chiego DJ, Arevang C, Zeng Q, Jackson LC, Bechler SA, Callaghan MU, Yoo GH, Sethi S, Lin HS, Callaghan JH, Tamayo-Castillo G, Sherman DH, Kaufman RJ, Fribley AM. PMID: 26617965.
      View in: PubMed   Mentions:
    54. Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts. ACS Med Chem Lett. 2015 Aug 13; 6(8):877-81. Cruz PG, Fribley AM, Miller JR, Larsen MJ, Schultz PJ, Jacob RT, Tamayo-Castillo G, Kaufman RJ, Sherman DH. PMID: 26288688.
      View in: PubMed   Mentions:
    55. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. PLoS One. 2015; 10(6):e0130635. D'Osualdo A, Anania VG, Yu K, Lill JR, Kaufman RJ, Matsuzawa S, Reed JC. PMID: 26086088.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    56. Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet. 2015 Jul; 47(7):757-65. Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, Hollander AI, Cremers FP, Lopez I, Ren H, Moore AT, Webster AR, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin JH. PMID: 26029869.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    57. C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. Circ Res. 2015 May 22; 116(11):1736-43. Zhou AX, Wang X, Lin CS, Han J, Yong J, Nadolski MJ, Borén J, Kaufman RJ, Tabas I. PMID: 25872946.
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    58. Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis. Diabetes. 2015 Aug; 64(8):2892-904. Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH, Katze MG, Kaufman RJ. PMID: 25795214.
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    59. Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Mol Biol Cell. 2015 Feb 15; 26(4):594-604. Wang S, Park S, Kodali VK, Han J, Yip T, Chen Z, Davidson NO, Kaufman RJ. PMID: 25518935.
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    61. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. ACS Med Chem Lett. 2014 Dec 11; 5(12):1278-1283. Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, Callaghan MU, Golden JE, Fribley AM, Kaufman RJ. PMID: 25530830.
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    63. Celastrol induces unfolded protein response-dependent cell death in head and neck cancer. Exp Cell Res. 2015 Jan 15; 330(2):412-422. Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, Kodali V, Kaufman RJ. PMID: 25139619.
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    64. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. PMID: 25132496.
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    65. Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling. J Biol Chem. 2014 Aug 29; 289(35):24417-27. Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT, Péterfy M. PMID: 25035425.
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    66. Novel bioinformatics method for identification of genome-wide non-canonical spliced regions using RNA-Seq data. PLoS One. 2014; 9(7):e100864. Bai Y, Hassler J, Ziyar A, Li P, Wright Z, Menon R, Omenn GS, Cavalcoli JD, Kaufman RJ, Sartor MA. PMID: 24991935.
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    67. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS One. 2014; 9(7):e101643. Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. PMID: 24992504.
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    68. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nat Neurosci. 2014 Aug; 17(8):1073-82. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. PMID: 24974795.
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    69. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal. 2014 Jul 20; 21(3):396-413. Cao SS, Kaufman RJ. PMID: 24702237.
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    70. Eukaryotic translation initiation factor 2 α phosphorylation as a therapeutic target in diabetes. Expert Rev Endocrinol Metab. 2014 Jul; 9(4):345-356. Yong J, Grankvist N, Han J, Kaufman RJ. PMID: 30763994.
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    71. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. PMID: 24917591.
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    72. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May; 10(5):e1004348. Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. PMID: 24809345.
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    73. Phosphorylation of eIF2α is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice. Inflamm Bowel Dis. 2014 Apr; 20(4):712-22. Cao SS, Wang M, Harrington JC, Chuang BM, Eckmann L, Kaufman RJ. PMID: 24577114.
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    74. How does protein misfolding in the endoplasmic reticulum affect lipid metabolism in the liver? Curr Opin Lipidol. 2014 Apr; 25(2):125-32. Wang S, Kaufman RJ. PMID: 24565920.
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    75. Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics. Biochim Biophys Acta. 2014 Oct; 1843(10):2233-9. Kaufman RJ, Malhotra JD. PMID: 24690484.
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    76. Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response. Mol Biol Cell. 2014 May; 25(9):1411-20. Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin JH. PMID: 24623724.
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    77. Glycoprotein folding and quality-control mechanisms in protein-folding diseases. Dis Model Mech. 2014 Mar; 7(3):331-41. Ferris SP, Kodali VK, Kaufman RJ. PMID: 24609034.
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    78. Measurement of the unfolded protein response to investigate its role in adipogenesis and obesity. Methods Enzymol. 2014; 538:135-50. Han J, Kaufman RJ. PMID: 24529437.
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    79. eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies. Aging (Albany NY). 2013 Dec; 5(12):884-901. Rajesh K, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Ferbeyre G, Kaufman RJ, Koromilas AE. PMID: 24334569.
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    80. Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network. Front Genet. 2013; 4:188. Arensdorf AM, Dezwaan McCabe D, Kaufman RJ, Rutkowski DT. PMID: 24069029.
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    82. Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J. 2013 Sep 11; 32(18):2477-90. Qiu Q, Zheng Z, Chang L, Zhao YS, Tan C, Dandekar A, Zhang Z, Lin Z, Gui M, Li X, Zhang T, Kong Q, Li H, Chen S, Chen A, Kaufman RJ, Yang WL, Lin HK, Zhang D, Perlman H, Thorp E, Zhang K, Fang D. PMID: 23942232.
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    83. UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum. Mol Biol Cell. 2013 Sep; 24(17):2597-608. Ferris SP, Jaber NS, Molinari M, Arvan P, Kaufman RJ. PMID: 23864712.
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    84. Transcriptional cross talk between orphan nuclear receptor ERRγ and transmembrane transcription factor ATF6α coordinates endoplasmic reticulum stress response. Nucleic Acids Res. 2013 Aug; 41(14):6960-74. Misra J, Kim DK, Choi W, Koo SH, Lee CH, Back SH, Kaufman RJ, Choi HS. PMID: 23716639.
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    85. C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. J Biol Chem. 2013 Jun 28; 288(26):18624-42. Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, Mauer AS, Yong J, Kaufman RJ. PMID: 23720735.
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    87. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol. 2013 May; 15(5):481-90. Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ. PMID: 23624402.
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    88. Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Cell Metab. 2013 Mar 05; 17(3):353-71. Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennedy TE, Sapieha P. PMID: 23473031.
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    89. PKR in DSS-induced colitis: a matter of genetic background and maternal microflora? Inflamm Bowel Dis. 2013 Mar; 19(3):E49-50. Cao SS, Kaufman RJ. PMID: 22508268.
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    90. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 2013 May; 144(5):989-1000.e6. Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ. PMID: 23336977.
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    94. IRE1, a double-edged sword in pre-miRNA slicing and cell death. Dev Cell. 2012 Nov 13; 23(5):921-3. Hassler J, Cao SS, Kaufman RJ. PMID: 23153490.
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    96. Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction. J Pathol. 2012 Dec; 228(4):554-64. Yung HW, Hemberger M, Watson ED, Senner CE, Jones CP, Kaufman RJ, Charnock-Jones DS, Burton GJ. PMID: 22733590.
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    98. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab. 2012 Aug 08; 16(2):265-73. Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F. PMID: 22883234.
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    99. The impact of the unfolded protein response on human disease. J Cell Biol. 2012 Jun 25; 197(7):857-67. Wang S, Kaufman RJ. PMID: 22733998.
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    100. RNA surveillance is required for endoplasmic reticulum homeostasis. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8079-84. Sakaki K, Yoshina S, Shen X, Han J, DeSantis MR, Xiong M, Mitani S, Kaufman RJ. PMID: 22562797.
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    102. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology. 2012 Apr; 55(4):1070-82. Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K. PMID: 22095841.
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    103. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis. 2012 Sep; 18(9):1735-42. Cao SS, Song B, Kaufman RJ. PMID: 22275310.
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    106. Beta-cell failure, stress, and type 2 diabetes. N Engl J Med. 2011 Nov 17; 365(20):1931-3. Kaufman RJ. PMID: 22087686.
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    109. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin. Blood. 2011 Sep 22; 118(12):3384-91. Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D. PMID: 21795745.
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    110. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Mol Biol Cell. 2011 Sep; 22(17):2994-3009. Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA. PMID: 21737679.
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    111. Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice. Haematologica. 2011 Sep; 96(9):1261-8. Mielke N, Schwarzer R, Calkhoven CF, Kaufman RJ, Dörken B, Leutz A, Jundt F. PMID: 21565905.
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    112. iRhoms: ERADicating the messenger in growth control signaling. Dev Cell. 2011 Apr 19; 20(4):414-6. Cao SS, Kaufman RJ. PMID: 21497754.
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    114. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab. 2011 Feb 02; 13(2):160-9. Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. PMID: 21284983.
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    115. Large-scale analysis of UPR-mediated apoptosis in human cells. Methods Enzymol. 2011; 491:57-71. Fribley AM, Miller JR, Reist TE, Callaghan MU, Kaufman RJ. PMID: 21329794.
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    116. Endoplasmic reticulum stress in liver disease. J Hepatol. 2011 Apr; 54(4):795-809. Malhi H, Kaufman RJ. PMID: 21145844.
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    117. Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell. 2010 Sep 15; 21(18):3220-31. Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE. PMID: 20660158.
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    119. Domain compatibility in Ire1 kinase is critical for the unfolded protein response. FEBS Lett. 2010 Jul 16; 584(14):3203-8. Poothong J, Sopha P, Kaufman RJ, Tirasophon W. PMID: 20541549.
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    131. Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response. J Biol Chem. 2009 Jul 03; 284(27):18202-9. Davies MJ, Miranda E, Roussel BD, Kaufman RJ, Marciniak SJ, Lomas DA. PMID: 19423713.
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    134. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1392-7. Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR, Perrin S, Feany MB, Horwich AL. PMID: 19171884.
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    142. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. J Biochem. 2008 Oct; 144(4):477-86. Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K. PMID: 18664523.
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    177. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 2006 Mar 08; 25(5):1114-25. Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. PMID: 16467844.
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    205. Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem. 2004 Jun 18; 279(25):25935-8. Zhang K, Kaufman RJ. PMID: 15070890.
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    206. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. PMID: 15029200.
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    207. Regulation of mRNA translation by protein folding in the endoplasmic reticulum. Trends Biochem Sci. 2004 Mar; 29(3):152-8. Kaufman RJ. PMID: 15003273.
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    208. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem. 2004 Apr 23; 279(17):17158-64. Tardif KD, Mori K, Kaufman RJ, Siddiqui A. PMID: 14960590.
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    209. Bioengineering of coagulation factor VIII for improved secretion. Blood. 2004 May 01; 103(9):3412-9. Miao HZ, Sirachainan N, Palmer L, Kucab P, Cunningham MA, Kaufman RJ, Pipe SW. PMID: 14726380.
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    210. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J. 2004 Jan 14; 23(1):169-79. Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D, Harding HP. PMID: 14713949.
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    211. A trip to the ER: coping with stress. Trends Cell Biol. 2004 Jan; 14(1):20-8. Rutkowski DT, Kaufman RJ. PMID: 14729177.
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    212. Stress-induced apoptosis in Spodoptera frugiperda (Sf9) cells: baculovirus p35 mitigates eIF2 alpha phosphorylation. Biochemistry. 2003 Dec 30; 42(51):15352-60. Aparna G, Bhuyan AK, Sahdev S, Hasnain SE, Kaufman RJ, Ramaiah KV. PMID: 14690445.
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    213. The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis. Virology. 2003 Dec 20; 317(2):263-74. Scheuner D, Gromeier M, Davies MV, Dorner AJ, Song B, Patel RV, Wimmer EJ, McLendon RE, Kaufman RJ. PMID: 14698665.
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    214. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol. 2003 Oct; 23(20):7198-209. Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. PMID: 14517290.
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    215. Unfolding the toxicity of cholesterol. Nat Cell Biol. 2003 Sep; 5(9):769-70. Zhang K, Kaufman RJ. PMID: 12951604.
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    216. The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain. J Biol Chem. 2003 Oct 31; 278(44):43320-8. Arnold SM, Kaufman RJ. PMID: 12913004.
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    217. IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast. Mol Microbiol. 2003 Aug; 49(3):591-606. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Schröder M, Clark R, Kaufman RJ. PMID: 12864846.
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    218. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol. 2003 Aug; 23(16):5651-63. Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC. PMID: 12897138.
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    219. Optimization of protease-inhibitor interactions by randomizing adventitious contacts. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8205-10. Komiyama T, VanderLugt B, Fugère M, Day R, Kaufman RJ, Fuller RS. PMID: 12832612.
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    220. Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nat Genet. 2003 Jun; 34(2):220-5. Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D. PMID: 12717434.
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    221. The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell. 2003 May 16; 113(4):519-31. Yaman I, Fernandez J, Liu H, Caprara M, Komar AA, Koromilas AE, Zhou L, Snider MD, Scheuner D, Kaufman RJ, Hatzoglou M. PMID: 12757712.
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    222. Compromised calnexin function in calreticulin-deficient cells. Biochem Biophys Res Commun. 2003 May 16; 304(4):661-6. Knee R, Ahsan I, Mesaeli N, Kaufman RJ, Michalak M. PMID: 12727205.
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    223. The unfolded protein response. J Cell Sci. 2003 May 15; 116(Pt 10):1861-2. Liu CY, Kaufman RJ. PMID: 12692187.
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    224. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem. 2003 Aug 08; 278(32):30317-27. Hossain GS, van Thienen JV, Werstuck GH, Zhou J, Sood SK, Dickhout JG, de Koning AB, Tang D, Wu D, Falk E, Poddar R, Jacobsen DW, Zhang K, Kaufman RJ, Austin RC. PMID: 12738777.
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    225. In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation. J Virol. 2003 Apr; 77(8):4626-34. Ward SL, Scheuner D, Poppers J, Kaufman RJ, Mohr I, Leib DA. PMID: 12663769.
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    226. All roads lead to ATF4. Dev Cell. 2003 Apr; 4(4):442-4. Rutkowski DT, Kaufman RJ. PMID: 12689582.
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    227. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem. 2003 Jun 06; 278(23):20915-24. Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ, Lee AS. PMID: 12665508.
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    228. Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. J Biol Chem. 2003 May 16; 278(20):17680-7. Liu CY, Xu Z, Kaufman RJ. PMID: 12637535.
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    229. A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell. 2003 Feb; 4(2):265-71. Yoshida H, Matsui T, Hosokawa N, Kaufman RJ, Nagata K, Mori K. PMID: 12586069.
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    230. The unfolded protein response is required for haploid tolerance in yeast. J Biol Chem. 2003 Apr 04; 278(14):11818-27. Lee K, Neigeborn L, Kaufman RJ. PMID: 12560331.
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    231. Orchestrating the unfolded protein response in health and disease. J Clin Invest. 2002 Nov; 110(10):1389-98. Kaufman RJ. PMID: 12438434.
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    232. Hemophilia A mutations within the factor VIII A2-A3 subunit interface destabilize factor VIIIa and cause one-stage/two-stage activity discrepancy. Thromb Haemost. 2002 Nov; 88(5):781-7. Hakeos WH, Miao H, Sirachainan N, Kemball-Cook G, Saenko EL, Kaufman RJ, Pipe SW. PMID: 12428094.
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    233. Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol. 2002 Aug 06; 12(15):1279-86. Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N. PMID: 12176355.
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    234. The unfolded protein response in nutrient sensing and differentiation. Nat Rev Mol Cell Biol. 2002 Jun; 3(6):411-21. Kaufman RJ, Scheuner D, Schröder M, Shen X, Lee K, Liu CY, Arnold SM. PMID: 12042763.
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    235. The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J Biol Chem. 2002 May 24; 277(21):18346-56. Liu CY, Wong HN, Schauerte JA, Kaufman RJ. PMID: 11897784.
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    236. Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum. J Biol Chem. 2002 May 17; 277(20):18077-83. Wu S, Hu Y, Wang JL, Chatterjee M, Shi Y, Kaufman RJ. PMID: 11877419.
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    237. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 2002 Feb 15; 16(4):452-66. Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ. PMID: 11850408.
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    238. Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):190-5. Tallóczy Z, Jiang W, Virgin HW, Leib DA, Scheuner D, Kaufman RJ, Eskelinen EL, Levine B. PMID: 11756670.
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