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    Ravinder Mittal

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0061
    CA La Jolla 92093
    Phone858-534-3328
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      Collapse Biography 
      Collapse Education and Training
      Delhi UniversityMedical DegreeMaulana Azad Medical College
      Delhi University HospitalInternship
      New York Medical CollegeResidencyLincoln Hospital
      Yale UniversityFellowshipSchool of Medicine

      Collapse Research 
      Collapse Research Activities and Funding
      Novel Electrical Impedance Methodology to Understand Functional Dysphagia
      NIH/NIDDK R01DK109376Sep 15, 2016 - Aug 31, 2021
      Role: Principal Investigator
      Anal Sphincter Morphology &Function Assessed with Novel MR Imaging Techniques
      NIH/NIDDK R01DK091348Sep 15, 2011 - Aug 31, 2016
      Role: Principal Investigator
      Novel Applications of Sarcomere Length to Improve Anal Continence
      VA I01RX000124Jul 1, 2009 - Sep 30, 2012
      Role: Principal Investigator
      Mechanosensory Motor Neurons of Lower Esophageal Sphincter
      VA I01BX000149Apr 1, 2009 - Mar 31, 2017
      Role: Principal Investigator
      ROLE OF PUBORECTALIS MUSCLE IN FECAL CONTINENCE
      NIH/NIDDK R01DK065846Sep 15, 2004 - Jul 31, 2008
      Role: Principal Investigator
      Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall Ischemia
      NIH/NIDDK R01DK060733Dec 1, 2001 - Mar 31, 2017
      Role: Principal Investigator
      PHARYNGEAL RECEPTORS AND REFLUX DISEASE
      NIH/NIDDK R01DK051604Jun 1, 1997 - Apr 30, 2003
      Role: Principal Investigator
      ANTICHOLINERGICS IN THE TREATMENT OF REFLUX DISEASE
      NIH/NIDDK R03DK052094Jan 10, 1997 - Dec 31, 2000
      Role: Principal Investigator
      BIENNIAL AMERICAN MOTILITY SYMPOSIUM
      NIH/NIDDK R13DK048248Sep 30, 1994 - Sep 29, 1995
      Role: Principal Investigator
      THE DIAPHRAGM--AN EXTERNAL LOWER ESOPHAGEAL SPHINCTER
      NIH/NIDDK R29DK040027Jan 1, 1989 - Dec 31, 1994
      Role: Principal Investigator
      General Clinical Research Center
      NIH M01RR000847Dec 1, 1977 - Feb 28, 2013
      Role: Co-Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Rajasekaran MR, Kanoo S, Fu J, Nguyen ML, Bhargava V, Mittal R. Age Related External Anal Sphincter Muscle Dysfunction & Fibrosis: Possible Role of Wnt-ß Catenin Signaling Pathways. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 24; ajpgi.00209.2017. PMID: 28838987.
        View in: PubMed
      2. Mittal R, Zifan A, Kumar D, Ledgerwood-Lee M, Ruppert E, Ghahremani G. Functional morphology of the lower esophageal sphincter and crural diaphragm determined by three-dimensional high-resolution esophago-gastric junction pressure profile and CT imaging. Am J Physiol Gastrointest Liver Physiol. 2017 Sep 01; 313(3):G212-G219. PMID: 28572086.
        View in: PubMed
      3. Jiang Y, Dong H, Eckmann L, Hanson EM, Ihn KC, Mittal R. Visualizing the enteric nervous system using genetically engineered double reporter mice: Comparison with immunofluorescence. PLoS One. 2017; 12(2):e0171239. PMID: 28158225.
        View in: PubMed
      4. Lee RH, Korsapati H, Bhalla V, Varki N, Mittal R. Esophageal Submucosal Injection of Capsaicin but Not Acid Induces Symptoms in Normal Subjects. J Neurogastroenterol Motil. 2016 Jul 30; 22(3):436-43. PMID: 26932896; PMCID: PMC4930298.
      5. Zifan A, Ledgerwood-Lee M, Mittal R. A Predictive Model to Identify Patients With Fecal Incontinence Based on High-Definition Anorectal Manometry. Clin Gastroenterol Hepatol. 2016 Dec; 14(12):1788-1796.e2. PMID: 27464594.
        View in: PubMed
      6. Mittal R. Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 01; 311(3):G431-43. PMID: 27445346.
        View in: PubMed
      7. Kim TH, Patel N, Ledgerwood-Lee M, Mittal R. Esophageal contractions in type 3 achalasia esophagus: simultaneous or peristaltic? Am J Physiol Gastrointest Liver Physiol. 2016 May 01; 310(9):G689-95. PMID: 26950858; PMCID: PMC4867325 [Available on 05/01/17].
      8. Jiang Y, Mittal R. Low esophageal mucosal blood flow in patients with nutcracker esophagus. Am J Physiol Gastrointest Liver Physiol. 2016 Mar 15; 310(6):G410-6. PMID: 26702139; PMCID: PMC4796296 [Available on 03/15/17].
      9. Patel N, Jiang Y, Mittal R, Kim TH, Ledgerwood M, Bhargava V. Circular and longitudinal muscles shortening indicates sliding patterns during peristalsis and transient lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 01; 309(5):G360-7. PMID: 26045610; PMCID: PMC4556947.
      10. Dong H, Jiang Y, Dong J, Mittal R. Inhibitory motor neurons of the esophageal myenteric plexus are mechanosensitive. Am J Physiol Cell Physiol. 2015 Mar 01; 308(5):C405-13. PMID: 25540174.
        View in: PubMed
      11. Mittal R, Sheean G, Padda BS, Rajasekaran MR. Length tension function of puborectalis muscle: implications for the treatment of fecal incontinence and pelvic floor disorders. J Neurogastroenterol Motil. 2014 Oct 30; 20(4):539-46. PMID: 25273124; PMCID: PMC4204420.
      12. Mittal R. Esophageal function testing: beyond manometry and impedance. Gastrointest Endosc Clin N Am. 2014 Oct; 24(4):667-85. PMID: 25216911; PMCID: PMC4428911.
      13. Rajasekaran MR, Sinha S, Seo Y, Salehi M, Bhargava V, Mittal R. Myoarchitectural and functional alterations in rabbit external anal sphincter muscle following experimental surgical trauma. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15; 307(4):G445-51. PMID: 24994856.
        View in: PubMed
      14. Mittal R, Bhargava V, Sheean G, Ledgerwood M, Sinha S. Purse-string morphology of external anal sphincter revealed by novel imaging techniques. Am J Physiol Gastrointest Liver Physiol. 2014 Mar; 306(6):G505-14. PMID: 24458022; PMCID: PMC3949029.
      15. Kim YS, Weinstein M, Raizada V, Jiang Y, Bhargava V, Rajasekaran MR, Mittal R. Anatomical disruption and length-tension dysfunction of anal sphincter complex muscles in women with fecal incontinence. Dis Colon Rectum. 2013 Nov; 56(11):1282-9. PMID: 24105004; PMCID: PMC3802525.
      16. Powley TL, Mittal R, Baronowsky EA, Hudson CN, Martin FN, McAdams JL, Mason JK, Phillips RJ. Architecture of vagal motor units controlling striated muscle of esophagus: peripheral elements patterning peristalsis? Auton Neurosci. 2013 Dec; 179(1-2):90-8. PMID: 24044976; PMCID: PMC3844123.
      17. Mittal R. Esophageal sphincter device/antireflux surgery: who needs it? Gastroenterology. 2013 Sep; 145(3):679-81. PMID: 23891608.
        View in: PubMed
      18. Mittal R. Longitudinal muscle of the esophagus: its role in esophageal health and disease. Curr Opin Gastroenterol. 2013 Jul; 29(4):421-30. PMID: 23739655.
        View in: PubMed
      19. Dong H, Jiang Y, Srinivasan S, Mittal R. Morphological, immunocytochemical, and functional characterization of esophageal enteric neurons in primary culture. Am J Physiol Gastrointest Liver Physiol. 2013 Jul 15; 305(2):G129-38. PMID: 23660501; PMCID: PMC4520575.
      20. Mittal R, Hong SJ, Bhargava V. Longitudinal muscle dysfunction in achalasia esophagus and its relevance. J Neurogastroenterol Motil. 2013 Apr; 19(2):126-36. PMID: 23667744; PMCID: PMC3644649.
      21. Rajasekaran MR, Sohn D, Salehi M, Bhargava V, Fritsch H, Mittal R. Role of puborectalis muscle in the genesis of urethral pressure. J Urol. 2012 Oct; 188(4):1382-8. PMID: 22906663.
        View in: PubMed
      22. Jiang Y, Bhargava V, Kim YS, Mittal R. Esophageal wall blood perfusion during contraction and transient lower esophageal sphincter relaxation in humans. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 01; 303(5):G529-35. PMID: 22790599; PMCID: PMC3468561.
      23. Leslie E, Bhargava V, Mittal R. A novel pattern of longitudinal muscle contraction with subthreshold pharyngeal stimulus: a possible mechanism of lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 01; 302(5):G542-7. PMID: 22173917; PMCID: PMC3311436.
      24. Mittal R, Karstens A, Leslie E, Babaei A, Bhargava V. Ambulatory high-resolution manometry, lower esophageal sphincter lift and transient lower esophageal sphincter relaxation. Neurogastroenterol Motil. 2012 Jan; 24(1):40-6, e2. PMID: 22074595; PMCID: PMC3746064.
      25. Rajasekaran MR, Jiang Y, Bhargava V, Ramamoorthy S, Lieber RL, Mittal R. Sustained improvement in the anal sphincter function following surgical plication of rabbit external anal sphincter muscle. Dis Colon Rectum. 2011 Nov; 54(11):1373-80. PMID: 21979181.
        View in: PubMed
      26. Mittal R, Bhargava V, Lal H, Jiang Y. Effect of esophageal contraction on esophageal wall blood perfusion. Am J Physiol Gastrointest Liver Physiol. 2011 Dec; 301(6):G1093-8. PMID: 21903762.
        View in: PubMed
      27. Jiang Y, Bhargava V, Lal HA, Mittal R. Variability in the muscle composition of rat esophagus and neural pathway of lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol. 2011 Dec; 301(6):G1014-9. PMID: 21885684.
        View in: PubMed
      28. Weinstein MM, Pretorius DH, Jung SA, Wan JJ, Nager CW, Mittal R. Anal sphincter complex muscles defects and dysfunction in asymptomatic parous women. Int Urogynecol J. 2011 Sep; 22(9):1143-50. PMID: 21604060.
        View in: PubMed
      29. Mittal R, Sheean G, Padda BS, Lieber R, Raj Rajasekaran M. The external anal sphincter operates at short sarcomere length in humans. Neurogastroenterol Motil. 2011 Jul; 23(7):643-e258. PMID: 21418426.
        View in: PubMed
      30. Jiang Y, Sandler B, Bhargava V, Mittal R. Antireflux action of Nissen fundoplication and stretch-sensitive mechanism of lower esophageal sphincter relaxation. Gastroenterology. 2011 Feb; 140(2):442-9. PMID: 20955702.
        View in: PubMed
      31. Park FD, Bain AJ, Mittal R. Granulocytic sarcoma of the colon. Clin Gastroenterol Hepatol. 2011 Jan; 9(1):A26. PMID: 20692367.
        View in: PubMed
      32. Lee JK, Bhargava V, Mittal R, Ghosh P. Achalasia, alcohol-stasis, and acute necrotizing esophagitis: connecting the dots. Dig Dis Sci. 2011 Feb; 56(2):612-4. PMID: 20552400; PMCID: PMC3029818.
      33. Raizada V, Bhargava V, Jung SA, Karstens A, Pretorius D, Krysl P, Mittal R. Dynamic assessment of the vaginal high-pressure zone using high-definition manometery, 3-dimensional ultrasound, and magnetic resonance imaging of the pelvic floor muscles. Am J Obstet Gynecol. 2010 Aug; 203(2):172.e1-8. PMID: 20462564; PMCID: PMC2910785.
      34. Hong SJ, Bhargava V, Jiang Y, Denboer D, Mittal R. A unique esophageal motor pattern that involves longitudinal muscles is responsible for emptying in achalasia esophagus. Gastroenterology. 2010 Jul; 139(1):102-11. PMID: 20381493; PMCID: PMC2950263.
      35. Sampath NJ, Bhargava V, Mittal R. Genesis of multipeaked waves of the esophagus: repetitive contractions or motion artifact? Am J Physiol Gastrointest Liver Physiol. 2010 Jun; 298(6):G927-33. PMID: 20360132; PMCID: PMC3774336.
      36. Babaei A, Bhargava V, Mittal R. Upper esophageal sphincter during transient lower esophageal sphincter relaxation: effects of reflux content and posture. Am J Physiol Gastrointest Liver Physiol. 2010 May; 298(5):G601-7. PMID: 20167874; PMCID: PMC2867416.
      37. Ramamoorthy SL, Lee JK, Mintz Y, Cullen J, Savu MK, Easter DW, Chock A, Mittal R, Horgan S, Talamini MA. The impact of proton-pump inhibitors on intraperitoneal sepsis: a word of caution for transgastric NOTES procedures. Surg Endosc. 2010 Jan; 24(1):16-20. PMID: 19551440.
        View in: PubMed
      38. Jiang Y, Bhargava V, Mittal R. Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter. Am J Physiol Gastrointest Liver Physiol. 2009 Aug; 297(2):G397-405. PMID: 19520741; PMCID: PMC2724084.
      39. Weinstein MM, Pretorius DH, Jung SA, Nager CW, Mittal R. Transperineal three-dimensional ultrasound imaging for detection of anatomic defects in the anal sphincter complex muscles. Clin Gastroenterol Hepatol. 2009 Feb; 7(2):205-11. PMID: 18996750; PMCID: PMC2835972.
      40. Rajasekaran MR, Jiang Y, Bhargava V, Littlefield R, Lee A, Lieber RL, Mittal R. Length-tension relationship of the external anal sphincter muscle: implications for the anal canal function. Am J Physiol Gastrointest Liver Physiol. 2008 Aug; 295(2):G367-73. PMID: 18599590; PMCID: PMC2519855.
      41. Korsapati H, Bhargava V, Mittal R. Reversal of asynchrony between circular and longitudinal muscle contraction in nutcracker esophagus by atropine. Gastroenterology. 2008 Sep; 135(3):796-802. PMID: 18675815.
        View in: PubMed
      42. Jung SA, Pretorius DH, Weinstein M, Nager CW, Den-Boer D, Mittal R. Closure mechanism of the anal canal in women: assessed by three-dimensional ultrasound imaging. Dis Colon Rectum. 2008 Jun; 51(6):932-9. PMID: 18330648.
        View in: PubMed
      43. Babaei A, Bhargava V, Korsapati H, Zheng WH, Mittal R. A unique longitudinal muscle contraction pattern associated with transient lower esophageal sphincter relaxation. Gastroenterology. 2008 May; 134(5):1322-31. PMID: 18384786.
        View in: PubMed
      44. Korsapati H, Babaei A, Bhargava V, Mittal R. Cholinergic stimulation induces asynchrony between the circular and longitudinal muscle contraction during esophageal peristalsis. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G694-8. PMID: 18187516.
        View in: PubMed
      45. Jung SA, Pretorius DH, Padda BS, Weinstein MM, Nager CW, den Boer DJ, Mittal R. Vaginal high-pressure zone assessed by dynamic 3-dimensional ultrasound images of the pelvic floor. Am J Obstet Gynecol. 2007 Jul; 197(1):52.e1-7. PMID: 17618755; PMCID: PMC2680732.
      46. Weinstein MM, Jung SA, Pretorius DH, Nager CW, den Boer DJ, Mittal R. The reliability of puborectalis muscle measurements with 3-dimensional ultrasound imaging. Am J Obstet Gynecol. 2007 Jul; 197(1):68.e1-6. PMID: 17618762.
        View in: PubMed
      47. Tipnis NA, Rhee PL, Mittal R. Distension during gastroesophageal reflux: effects of acid inhibition and correlation with symptoms. Am J Physiol Gastrointest Liver Physiol. 2007 Aug; 293(2):G469-74. PMID: 17556589.
        View in: PubMed
      48. Dogan I, Puckett JL, Padda BS, Mittal R. Prevalence of increased esophageal muscle thickness in patients with esophageal symptoms. Am J Gastroenterol. 2007 Jan; 102(1):137-45. PMID: 17266691.
        View in: PubMed
      49. Dogan I, Bhargava V, Liu J, Mittal R. Axial stretch: A novel mechanism of the lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G329-34. PMID: 17023549.
        View in: PubMed
      50. Padda BS, Jung SA, Pretorius D, Nager CW, Den-Boer D, Mittal R. Effects of pelvic floor muscle contraction on anal canal pressure. Am J Physiol Gastrointest Liver Physiol. 2007 Feb; 292(2):G565-71. PMID: 17023551.
        View in: PubMed
      51. Dogan I, Mittal R. Esophageal motor disorders: recent advances. Curr Opin Gastroenterol. 2006 Jul; 22(4):417-22. PMID: 16760760.
        View in: PubMed
      52. Liu J, Guaderrama N, Nager CW, Pretorius DH, Master S, Mittal R. Functional correlates of anal canal anatomy: puborectalis muscle and anal canal pressure. Am J Gastroenterol. 2006 May; 101(5):1092-7. PMID: 16606349.
        View in: PubMed
      53. Tipnis NA, Liu J, Puckett JL, Mittal R. Common cavity pressure during gastroesophageal reflux: reassessment using simultaneous pressure, impedance, and ultrasound imaging. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 290(6):G1149-56. PMID: 16439471.
        View in: PubMed
      54. Mittal R, Padda B, Bhalla V, Bhargava V, Liu J. Synchrony between circular and longitudinal muscle contractions during peristalsis in normal subjects. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G431-8. PMID: 16210472.
        View in: PubMed
      55. Guaderrama NM, Liu J, Nager CW, Pretorius DH, Sheean G, Kassab G, Mittal R. Evidence for the innervation of pelvic floor muscles by the pudendal nerve. Obstet Gynecol. 2005 Oct; 106(4):774-81. PMID: 16199635.
        View in: PubMed
      56. Jung HY, Puckett JL, Bhalla V, Rojas-Feria M, Bhargava V, Liu J, Mittal R. Asynchrony between the circular and the longitudinal muscle contraction in patients with nutcracker esophagus. Gastroenterology. 2005 May; 128(5):1179-86. PMID: 15887102.
        View in: PubMed
      57. Mittal R. Motor and sensory function of the esophagus: revelations through ultrasound imaging. J Clin Gastroenterol. 2005 Apr; 39(4 Suppl 2):S42-8. PMID: 15758658.
        View in: PubMed
      58. Mittal R, Liu J. Flow across the gastro-esophageal junction: lessons from the sleeve sensor on the nature of anti-reflux barrier. Neurogastroenterol Motil. 2005 Apr; 17(2):187-90. PMID: 15787938.
        View in: PubMed
      59. Mittal R, Liu J, Puckett JL, Bhalla V, Bhargava V, Tipnis N, Kassab G. Sensory and motor function of the esophagus: lessons from ultrasound imaging. Gastroenterology. 2005 Feb; 128(2):487-97. PMID: 15685559.
        View in: PubMed
      60. Guaderrama NM, Nager CW, Liu J, Pretorius DH, Mittal R. The vaginal pressure profile. Neurourol Urodyn. 2005; 24(3):243-7. PMID: 15714439.
        View in: PubMed
      61. Puckett JL, Liu J, Bhalla V, Kravetz D, Krinsky ML, Hassanein T, Mittal R. Ultrasound system to measure esophageal varix pressure: an in vitro validation study. Am J Physiol Gastrointest Liver Physiol. 2005 May; 288(5):G914-9. PMID: 15626729.
        View in: PubMed
      62. Liu J, Puckett JL, Takeda T, Jung HY, Mittal R. Crural diaphragm inhibition during esophageal distension correlates with contraction of the esophageal longitudinal muscle in cats. Am J Physiol Gastrointest Liver Physiol. 2005 May; 288(5):G927-32. PMID: 15626730.
        View in: PubMed
      63. Mittal R, Bhalla V. Oesophageal motor functions and its disorders. Gut. 2004 Oct; 53(10):1536-42. PMID: 15361508; PMCID: PMC1774230.
      64. Bhalla V, Liu J, Puckett JL, Mittal R. Symptom hypersensitivity to acid infusion is associated with hypersensitivity of esophageal contractility. Am J Physiol Gastrointest Liver Physiol. 2004 Jul; 287(1):G65-71. PMID: 14977636.
        View in: PubMed
      65. Mittal R, Kassab GS. Esophagogastric junction opening: does it explain the difference between normal subjects and patients with reflux disease? Gastroenterology. 2003 Oct; 125(4):1258-60. PMID: 14517807.
        View in: PubMed
      66. Mittal R. Measuring esophageal distention by high-frequency intraluminal ultrasound probe. Am J Med. 2003 Aug 18; 115 Suppl 3A:130S-136S. PMID: 12928089.
        View in: PubMed
      67. Mittal R, Kassab G, Puckett JL, Liu J. Hypertrophy of the muscularis propria of the lower esophageal sphincter and the body of the esophagus in patients with primary motility disorders of the esophagus. Am J Gastroenterol. 2003 Aug; 98(8):1705-12. PMID: 12907322.
        View in: PubMed
      68. Takeda T, Kassab G, Liu J, Nabae T, Mittal R. Effect of atropine on the biomechanical properties of the oesophageal wall in humans. J Physiol. 2003 Mar 01; 547(Pt 2):621-8. PMID: 12562937; PMCID: PMC2342665.
      69. Steinbach J, Fass R, Mittal R. Assessment of relationship between acid reflux and heartburn using receiver operating characteristic curves. Gastroenterol Clin North Am. 2002 Dec; 31(4 Suppl):S45-58. PMID: 12489470.
        View in: PubMed
      70. Rhee PL, Liu J, Puckett JL, Mittal R. Measuring esophageal distension by high-frequency intraluminal ultrasound probe. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G886-92. PMID: 12223348.
        View in: PubMed
      71. Pehlivanov N, Liu J, Kassab GS, Beaumont C, Mittal R. Relationship between esophageal muscle thickness and intraluminal pressure in patients with esophageal spasm. Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G1016-23. PMID: 12016127.
        View in: PubMed
      72. Takeda T, Kassab G, Liu J, Puckett JL, Mittal RR, Mittal R. A novel ultrasound technique to study the biomechanics of the human esophagus in vivo. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G785-93. PMID: 11960775.
        View in: PubMed
      73. Liu J, Pehlivanov N, Mittal R. Baclofen blocks LES relaxation and crural diaphragm inhibition by esophageal and gastric distension in cats. Am J Physiol Gastrointest Liver Physiol. 2002 Dec; 283(6):G1276-81. PMID: 12388201.
        View in: PubMed
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