Marygorret Obonyo

Title(s)Associate Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Treatment and Response Targets for Helicobacter-Associated Gastric Cancer
    DoD W81XWH-20-1-0675Jul 15, 2020 - Jul 14, 2022
    Role: Principal Investigator
    MyD88-dependent mechanisms of Helicobacter pylori-induced gastric cancer progression
    NIH R21CA210227Mar 3, 2017 - Feb 29, 2020
    Role: Principal Investigator
    Role of inflammatory microenvironment in Helicobacter-induced gastric cancer
    NIH R21CA188752Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Immunological Basis for H. Pylori-Related Malignancies
    NIH K01CA096709Sep 1, 2002 - Aug 31, 2008
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TRIF-IFN-I pathway in Helicobacter-induced gastric cancer in an accelerated murine disease model and patient biopsies. iScience. 2024 Apr 19; 27(4):109457. Bali P, Lozano-Pope I, Hernandez J, Estrada MV, Corr M, Turner MA, Bouvet M, Benner C, Obonyo M. PMID: 38558931; PMCID: PMC10981133.
      View in: PubMed   Mentions:
    2. Humanized Anti-Carcinoembryonic Antigen Antibodies Brightly Target and Label Gastric Cancer in Orthotopic Mouse Models. J Surg Res. 2024 01; 293:701-708. Cox KE, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Ghosh P, Obonyo M, Murakami T, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 37839102.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Activation of the TRIF pathway and downstream targets results in the development of precancerous lesions during infection with Helicobacter. bioRxiv. 2023 Aug 16. Bali P, Lozano-Pope I, Hernandez J, Estrada MV, Corr M, Turner MA, Bouvet M, Benner C, Obonyo M. PMID: 37333238; PMCID: PMC10274671.
      View in: PubMed   Mentions:
    4. A Bioluminescence-Based Drug Screen Identifies Activities of Fexinidazole and Its Metabolites against Helicobacter pylori. Antibiotics (Basel). 2022 Nov 11; 11(11). Mohamed A, Chilingerian JN, Bali P, Obonyo M, Debnath A. PMID: 36421252; PMCID: PMC9686901.
      View in: PubMed   Mentions:
    5. Genomically Silent Refractory Gastric Cancer in a Young Patient Exhibits Overexpression of CXCL5. Curr Oncol. 2022 07 06; 29(7):4725-4733. Hernandez J, Turner MA, Bali P, Hosseini M, Bouvet M, Kelly K, Obonyo M. PMID: 35877235; PMCID: PMC9320515.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Microbiome Signatures in a Fast- and Slow-Progressing Gastric Cancer Murine Model and Their Contribution to Gastric Carcinogenesis. Microorganisms. 2021 Jan 17; 9(1). Bali P, Coker J, Lozano-Pope I, Zengler K, Obonyo M. PMID: 33477306; PMCID: PMC7829848.
      View in: PubMed   Mentions: 7  
    7. Early detection of tumor cells in bone marrow and peripheral blood in a fast‑progressing gastric cancer model. Int J Oncol. 2021 03; 58(3):388-396. Bali P, Lozano-Pope I, Pachow C, Obonyo M. PMID: 33469673; PMCID: PMC7864146.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. Inhibition of Pathogen Adhesion by Bacterial Outer Membrane-Coated Nanoparticles. Angew Chem Int Ed Engl. 2019 08 12; 58(33):11404-11408. Zhang Y, Chen Y, Lo C, Zhuang J, Angsantikul P, Zhang Q, Wei X, Zhou Z, Obonyo M, Fang RH, Gao W, Zhang L. PMID: 31206942.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    9. Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection. Sci Rep. 2019 05 07; 9(1):7030. Mejías-Luque R, Lozano-Pope I, Wanisch A, Heikenwälder M, Gerhard M, Obonyo M. PMID: 31065023; PMCID: PMC6504916.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. Coating nanoparticles with gastric epithelial cell membrane for targeted antibiotic delivery against Helicobacter pylori infection. Adv Ther (Weinh). 2018 Jun; 1(2). Angsantikul P, Thamphiwatana S, Zhang Q, Spiekermann K, Zhuang J, Fang RH, Gao W, Obonyo M, Zhang L. PMID: 30320205; PMCID: PMC6176867.
      View in: PubMed   Mentions: 42  
    11. Comparison of lipopolysaccharides composition of two different strains of Helicobacter pylori. BMC Microbiol. 2017 Dec 04; 17(1):226. Leker K, Lozano-Pope I, Bandyopadhyay K, Choudhury BP, Obonyo M. PMID: 29202699; PMCID: PMC5715995.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    12. Author correction: Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. Nat Commun. 2017 10 31; 8(1):1299. de Ávila BE, Angsantikul P, Li J, Angel Lopez-Ramirez M, Ramírez-Herrera DE, Thamphiwatana S, Chen C, Delezuk J, Samakapiruk R, Ramez V, Obonyo M, Zhang L, Wang J. PMID: 29089506; PMCID: PMC5663909.
      View in: PubMed   Mentions: 1     Fields:    
    13. Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. Nat Commun. 2017 08 16; 8(1):272. de Ávila BE, Angsantikul P, Li J, Angel Lopez-Ramirez M, Ramírez-Herrera DE, Thamphiwatana S, Chen C, Delezuk J, Samakapiruk R, Ramez V, Obonyo M, Zhang L, Wang J. PMID: 28814725; PMCID: PMC5559609.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    14. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. BMC Cancer. 2017 02 15; 17(1):133. Lozano-Pope I, Sharma A, Matthias M, Doran KS, Obonyo M. PMID: 28201999; PMCID: PMC5310019.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1). BMC Microbiol. 2015 Oct 21; 15:222. King CC, Obonyo M. PMID: 26487493; PMCID: PMC4618363.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. PLoS One. 2015; 10(3):e0116519. Jung SW, Thamphiwatana S, Zhang L, Obonyo M. PMID: 25793403; PMCID: PMC4368202.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    17. Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection. J Mater Chem B. 2014 Dec 14; 2(46):8201-8207. Thamphiwatana S, Gao W, Pornpattananangkul D, Zhang Q, Fu V, Li J, Li J, Obonyo M, Zhang L. PMID: 25544886; PMCID: PMC4276341.
      View in: PubMed   Mentions: 25     Fields:    
    18. In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):17600-5. Thamphiwatana S, Gao W, Obonyo M, Zhang L. PMID: 25422427; PMCID: PMC4267350.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    19. Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy. Infect Immun. 2014 Jan; 82(1):356-63. Banerjee A, Thamphiwatana S, Carmona EM, Rickman B, Doran KS, Obonyo M. PMID: 24166959; PMCID: PMC3911874.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    20. Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori. Mol Pharm. 2012 Sep 04; 9(9):2677-85. Obonyo M, Zhang L, Thamphiwatana S, Pornpattananangkul D, Fu V, Zhang L. PMID: 22827534; PMCID: PMC3433584.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    21. Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response. Helicobacter. 2011 Oct; 16(5):398-404. Obonyo M, Rickman B, Guiney DG. PMID: 21923686; PMCID: PMC3535435.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection. J Am Chem Soc. 2011 Mar 23; 133(11):4132-9. Pornpattananangkul D, Zhang L, Olson S, Aryal S, Obonyo M, Vecchio K, Huang CM, Zhang L. PMID: 21344925; PMCID: PMC3062754.
      View in: PubMed   Mentions: 77     Fields:    Translation:Cells
    23. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI. PMID: 18986247; PMCID: PMC3584630.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    24. Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. Infect Immun. 2007 May; 75(5):2408-14. Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney DG. PMID: 17353291; PMCID: PMC1865764.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    25. Evidence for interleukin-1-independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori-infected murine dendritic cells deficient in the interleukin-1 receptor. FEMS Immunol Med Microbiol. 2006 Aug; 47(3):414-9. Obonyo M, Cole SP, Datta SK, Guiney DG. PMID: 16872378.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology. 2003 Dec; 125(6):1613-25. Hase K, Murakami M, Iimura M, Cole SP, Horibe Y, Ohtake T, Obonyo M, Gallo RL, Eckmann L, Kagnoff MF. PMID: 14724813.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    27. Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection. Helicobacter. 2003; 8(5):495-502. Obonyo M, Guiney DG, Fierer J, Cole SP. PMID: 14535996.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    28. Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection. Infect Immun. 2002 Jun; 70(6):3295-9. Obonyo M, Guiney DG, Harwood J, Fierer J, Cole SP. PMID: 12011029; PMCID: PMC127973.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    29. Cultivation at 37 degrees C enhances Borrelia burgdorferi sensu stricto infectivity for hamsters. Med Microbiol Immunol. 2002 May; 191(1):33-9. Obonyo M, Munderloh UG, Sam TN, Kurtti TJ. PMID: 12137197.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. Borrelia burgdorferi in tick cell culture modulates expression of outer surface proteins A and C in response to temperature. J Clin Microbiol. 1999 Jul; 37(7):2137-41. Obonyo M, Munderloh UG, Fingerle V, Wilske B, Kurtti TJ. PMID: 10364575; PMCID: PMC85101.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
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