Jesus Rivera-nieves

Title(s)	Adjunct Professor, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

Fellowship Training	2001	University of Virginia, Charlottesville, VA
Research Fellowship	1998	Pulmonary Medicine Branch, National Hearth, Lung and Blood Institute, National Institutes of Health
Residency	1993	University of Maryland, Baltimore, MD
MD	1990	University of Puerto Rico, San Juan, PR
BS	1985	University of Puerto Rico, San Juan, PR

Overview

Websites

	Division of Gastroenterology
	Clinical Profile

Research

Research Activities and Funding

HIV Persistence and Renewal in the Gastrointestinal, Genitourinary and Adipose Tissues
NIH R01DK131532Sep 17, 2021 - Jul 31, 2026
Role: Co-Principal Investigator

Immunoprofiling for identifying biomarkers in celiac disease
NIH R21AI149636Feb 12, 2020 - Jan 31, 2022
Role: Co-Principal Investigator

High Dimensional Mass Cytometry Analysis of the Effects of Vedolizumab in Intestinal Cellular Subsets and its Correlation with Clinical Parameters
NIH R21DK118927Apr 8, 2019 - Mar 31, 2021
Role: Principal Investigator

Dendritic Cell Regulation by Sphingosine-1-phosphate in Inflammatory Bowel Disease
NIH I01BX003436Oct 1, 2018 - Sep 30, 2022
Role: Principal Investigator

Novel Traffic-targeted Therapies for IBD
NIH R01DK108670Jan 1, 2016 - Dec 31, 2021
Role: Principal Investigator

Dendritic Cell Manipulation: A Novel Therapeutic for Inflammatory Bowel Disease
NIH I01BX001051Apr 1, 2011 - Mar 31, 2016
Role: Principal Investigator

Targeting L-Selectin in Chronic Murine Ileitis
NIH R01DK080212Jul 20, 2009 - Jun 30, 2015
Role: Principal Investigator

Role of L-selectin and its Ligands in Chronic Murine Ileitis
NIH R03DK073280Sep 1, 2006 - Aug 31, 2009
Role: Principal Investigator

Lymphocyte Trafficking by Chemokines/Adhesion Molecules in Crohn's Disease
NIH K08DK067254Jul 1, 2004 - Jun 30, 2010
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Class Ib MHC-Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine. Immunohorizons. 2021 12 15; 5(12):953-971. Dasgupta S, Maricic I, Tang J, Wandro S, Weldon K, Carpenter CS, Eckmann L, Rivera-Nieves J, Sandborn W, Knight R, Dorrestein P, Swafford AD, Kumar V. PMID: 34911745; PMCID: PMC10026853.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Animals Cells
Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer. Front Cell Infect Microbiol. 2021; 11:752304. Campillo-Gimenez L, Rios-Covian D, Rivera-Nieves J, Kiyono H, Chu H, Ernst PB. PMID: 34869061; PMCID: PMC8633303.

View in: PubMed Mentions: 3 Fields:
Cel Cell Biology Com Communicable Diseases Mic Microbiology
Translation:Humans Cells
Biomarkers are associated with clinical and endoscopic outcomes with vedolizumab treatment in Crohn's disease. Therap Adv Gastroenterol. 2020; 13:1756284820971214. Holmer AK, Battat R, Dulai PS, Vande Casteele N, Nguyen N, Jain A, Miralles A, Neill J, Le H, Singh S, Rivera-Nieves J, Sandborn WJ, Boland BS. PMID: 33240396; PMCID: PMC7675888.

View in: PubMed Mentions: 2
Targeting Beta-7 Integrins for the Treatment of Inflammatory Bowel Disease. Gastroenterol Hepatol (N Y). 2020 Jul; 16(7):367-369. Rivera-Nieves J. PMID: 34035742; PMCID: PMC8132642.

View in: PubMed Mentions:
Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases? Clin Gastroenterol Hepatol. 2019 12; 17(13):2634-2643. Dulai PS, Singh S, Vande Casteele N, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ. PMID: 31009791; PMCID: PMC6885453.

View in: PubMed Mentions: 47 Fields:
Gas Gastroenterology
Translation:Humans Cells
Biomarkers Are Associated With Clinical and Endoscopic Outcomes With Vedolizumab Treatment in Ulcerative Colitis. Inflamm Bowel Dis. 2019 01 10; 25(2):410-420. Battat R, Dulai PS, Vande Casteele N, Evans E, Hester KD, Webster E, Jain A, Proudfoot JA, Mairalles A, Neill J, Singh S, Chang JT, Rivera-Nieves J, Sandborn WJ, Boland BS. PMID: 30295781; PMCID: PMC6327228.

View in: PubMed Mentions: 13 Fields:
Gas Gastroenterology
Translation:Humans
Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut. Front Immunol. 2018; 9:2082. Marrero I, Maricic I, Feldstein AE, Loomba R, Schnabl B, Rivera-Nieves J, Eckmann L, Kumar V. PMID: 30254647; PMCID: PMC6141878.

View in: PubMed Mentions: 23 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Targeting leukocyte traffic: A new era for the treatment of Inflammatory bowel disease. J Crohns Colitis. 2018 Aug 22; 12(suppl_2):S631-S632. Rivera-Nieves J. PMID: 30137310; PMCID: PMC6104620.

View in: PubMed Mentions: 1 Fields:
Gas Gastroenterology
Translation:Humans Animals Cells
Development and Validation of a Scoring System to Predict Outcomes of Vedolizumab Treatment in Patients With Crohn's Disease. Gastroenterology. 2018 09; 155(3):687-695.e10. Dulai PS, Boland BS, Singh S, Chaudrey K, Koliani-Pace JL, Kochhar G, Parikh MP, Shmidt E, Hartke J, Chilukuri P, Meserve J, Whitehead D, Hirten R, Winters AC, Katta LG, Peerani F, Narula N, Sultan K, Swaminath A, Bohm M, Lukin D, Hudesman D, Chang JT, Rivera-Nieves J, Jairath V, Zou GY, Feagan BG, Shen B, Siegel CA, Loftus EV, Kane S, Sands BE, Colombel JF, Sandborn WJ, Lasch K, Cao C. PMID: 29857091; PMCID: PMC6419724.

View in: PubMed Mentions: 44 Fields:
Gas Gastroenterology
Translation:Humans
Defective Lymphatics in Crohn's Disease: Tertiary Lymphoid Follicles Plug the Gap. Gastroenterology. 2017 03; 152(4):908-910. McNamee EN, Rivera-Nieves J. PMID: 28153586; PMCID: PMC9924356.

View in: PubMed Mentions: 2 Fields:
Gas Gastroenterology
Targeting S1P Receptors, A New Mechanism of Action for Inflammatory Bowel Disease Therapy. Gastroenterology. 2016 Nov; 151(5):1025-1027. Bamias G, Rivera-Nieves J. PMID: 27693331; PMCID: PMC9927550.

View in: PubMed Mentions: 3 Fields:
Gas Gastroenterology
Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease. Mucosal Immunol. 2017 01; 10(1):162-171. Karuppuchamy T, Behrens EH, González-Cabrera P, Sarkisyan G, Gima L, Boyer JD, Bamias G, Jedlicka P, Veny M, Clark D, Peach R, Scott F, Rosen H, Rivera-Nieves J. PMID: 27049060; PMCID: PMC5053832.

View in: PubMed Mentions: 38 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Anti-Interleukin-12/23 Blockade Offers Novel Therapeutic Opportunities for the "Difficult" Patient with Crohn's Disease. Gastroenterology. 2016 05; 150(5):1237-1239. Rivera-Nieves J, Bamias G. PMID: 27018181; PMCID: PMC9924354.

View in: PubMed Mentions: Fields:
Gas Gastroenterology
Translation:Humans
Opportunities for Improvement in the Care of Patients Hospitalized for Inflammatory Bowel Disease-Related Colitis. Dig Dis Sci. 2016 Apr; 61(4):1003-12. Lee NS, Pola S, Groessl EJ, Rivera-Nieves J, Ho SB. PMID: 26860508; PMCID: PMC5716623.

View in: PubMed Mentions: 5 Fields:
Gas Gastroenterology
Translation:Humans
Integrin-based therapeutics: biological basis, clinical use and new drugs. Nat Rev Drug Discov. 2016 Mar; 15(3):173-83. Ley K, Rivera-Nieves J, Sandborn WJ, Shattil S. PMID: 26822833; PMCID: PMC4890615.

View in: PubMed Mentions: 171 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Animals Cells
Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. PMID: 25545378; PMCID: PMC4404151.

View in: PubMed Mentions: 5 Fields:
Gas Gastroenterology
Translation:Humans
Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Aliment Pharmacol Ther. 2014 Sep; 40(5):477-85. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT. PMID: 25041724; PMCID: PMC4143528.

View in: PubMed Mentions: 5 Fields:
Dru Drug Therapy Gas Gastroenterology Pha Pharmacology
Translation:Humans
T-cell trafficking and anti-adhesion strategies in inflammatory bowel disease: current and future prospects. Drugs. 2014 Mar; 74(3):297-311. Mosli MH, Rivera-Nieves J, Feagan BG. PMID: 24452878.

View in: PubMed Mentions: 16 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Cells
Leukocyte traffic blockade as a therapeutic strategy in inflammatory bowel disease. Curr Drug Targets. 2013 Nov; 14(12):1490-500. Bamias G, Clark DJ, Rivera-Nieves J. PMID: 23621509; PMCID: PMC3779486.

View in: PubMed Mentions: 23 Fields:
Dru Drug Therapy
Translation:Humans Animals Cells
A call for investment in education of US minorities in the 21(st) century. Gastroenterology. 2013 May; 144(5):863-7. Rivera-Nieves J, Abreu MT. PMID: 23523955; PMCID: PMC3684384.

View in: PubMed Mentions: 3 Fields:
Gas Gastroenterology
Translation:Humans
Strategies for the care of adults hospitalized for active ulcerative colitis. Clin Gastroenterol Hepatol. 2012 Dec; 10(12):1315-1325.e4. Pola S, Patel D, Ramamoorthy S, McLemore E, Fahmy M, Rivera-Nieves J, Chang JT, Evans E, Docherty M, Talamini M, Sandborn WJ. PMID: 22835577; PMCID: PMC4226798.

View in: PubMed Mentions: 14 Fields:
Gas Gastroenterology
Translation:Humans
Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice. J Immunol. 2010 Nov 01; 185(9):5561-8. Gorfu G, Rivera-Nieves J, Hoang S, Abbott DW, Arbenz-Smith K, Azar DW, Pizarro TT, Cominelli F, McDuffie M, Ley K. PMID: 20926792; PMCID: PMC3228636.

View in: PubMed Mentions: 16 Fields:
All Allergy and Immunology
Translation:Animals Cells
T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo. J Immunol. 2009 Nov 01; 183(9):5685-93. Smith E, von Vietinghoff S, Stark MA, Zarbock A, Sanders JM, Duley A, Rivera-Nieves J, Bender TP, Ley K. PMID: 19843951; PMCID: PMC2893017.

View in: PubMed Mentions: 7 Fields:
All Allergy and Immunology
Translation:Animals Cells
Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation. Expert Opin Ther Targets. 2009 Nov; 13(11):1267-77. Eltzschig HK, Rivera-Nieves J, Colgan SP. PMID: 19769545; PMCID: PMC4077533.

View in: PubMed Mentions: 36 Fields:
The Therapeutics
Translation:Humans Animals Cells
Role of beta7 integrins in intestinal lymphocyte homing and retention. Curr Mol Med. 2009 Sep; 9(7):836-50. Gorfu G, Rivera-Nieves J, Ley K. PMID: 19860663; PMCID: PMC2770881.

View in: PubMed Mentions: 133 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis. J Immunol. 2007 Nov 15; 179(10):7012-20. Barnes SL, Vidrich A, Wang ML, Wu GD, Cominelli F, Rivera-Nieves J, Bamias G, Cohn SM. PMID: 17982092.

View in: PubMed Mentions: 22 Fields:
All Allergy and Immunology
Translation:Animals Cells
Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis. J Immunol. 2007 Feb 01; 178(3):1809-18. Bamias G, Okazawa A, Rivera-Nieves J, Arseneau KO, De La Rue SA, Pizarro TT, Cominelli F. PMID: 17237431.

View in: PubMed Mentions: 42 Fields:
All Allergy and Immunology
Translation:Animals Cells
Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8441-6. Bamias G, Mishina M, Nyce M, Ross WG, Kollias G, Rivera-Nieves J, Pizarro TT, Cominelli F. PMID: 16698931; PMCID: PMC1482511.

View in: PubMed Mentions: 80 Fields:
Sci Science
Translation:Animals Cells
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease. Gastroenterology. 2006 Jan; 130(1):8-16. Bachmann C, Klibanov AL, Olson TS, Sonnenschein JR, Rivera-Nieves J, Cominelli F, Ley KF, Lindner JR, Pizarro TT. PMID: 16401463.

View in: PubMed Mentions: 51 Fields:
Gas Gastroenterology
Translation:Animals
Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease. Gastroenterology. 2005 Jul; 129(1):26-33. Odashima M, Bamias G, Rivera-Nieves J, Linden J, Nast CC, Moskaluk CA, Marini M, Sugawara K, Kozaiwa K, Otaka M, Watanabe S, Cominelli F. PMID: 16012931.

View in: PubMed Mentions: 99 Fields:
Gas Gastroenterology
Translation:Animals Cells
Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation. Gastroenterology. 2005 Mar; 128(3):654-66. Bamias G, Martin C, Mishina M, Ross WG, Rivera-Nieves J, Marini M, Cominelli F. PMID: 15765401.

View in: PubMed Mentions: 69 Fields:
Gas Gastroenterology
Translation:Animals Cells
Role of human neutrophil peptides in lung inflammation associated with alpha1-antitrypsin deficiency. Am J Physiol Lung Cell Mol Physiol. 2004 Mar; 286(3):L514-20. Spencer LT, Paone G, Krein PM, Rouhani FN, Rivera-Nieves J, Brantly ML. PMID: 14594730.

View in: PubMed Mentions: 31 Fields:
Cel Cell Biology Mol Molecular Biology Phy Physiology Pul Pulmonary Medicine
Translation:Humans Cells
Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice. Gastroenterology. 2001 Dec; 121(6):1428-36. Burns RC, Rivera-Nieves J, Moskaluk CA, Matsumoto S, Cominelli F, Ley K. PMID: 11729122.

View in: PubMed Mentions: 83 Fields:
Gas Gastroenterology
Translation:Animals Cells
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest. 2001 Mar; 107(6):695-702. Kosiewicz MM, Nast CC, Krishnan A, Rivera-Nieves J, Moskaluk CA, Matsumoto S, Kozaiwa K, Cominelli F. PMID: 11254669; PMCID: PMC208944.

View in: PubMed Mentions: 78 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Marked transaminase elevation in anorexia nervosa. Dig Dis Sci. 2000 Oct; 45(10):1959-63. Rivera-Nieves J, Kozaiwa K, Parrish CR, Iezzoni J, Berg CL. PMID: 11117567.

View in: PubMed Mentions: 5 Fields:
Gas Gastroenterology
Translation:Humans
Image of the month. Esophageal foreign body. Gastroenterology. 2000 Jan; 118(1):6, 243. Rivera-Nieves J, Battle E, Alfert J. PMID: 17165207.

View in: PubMed Mentions: Fields:
Gas Gastroenterology
Translation:Humans