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    Frances Gillin

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    Address200 W. Arbor Drive #8416
    CA San Diego 92103
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      Collapse Research 
      Collapse Research Activities and Funding
      Mechanisms of Giardia Iamblia Excystation
      NIH/NIAID R01AI051687Apr 1, 2003 - Mar 31, 2008
      Role: Principal Investigator
      Mechanisms of Giardia Lamblia Cyst Wall Formation
      NIH/NIGMS R01GM061896Sep 28, 2001 - Aug 31, 2007
      Role: Principal Investigator
      Centrosomal Proteins in Giardia Differentiation
      NIH/NIAID R01AI042488Aug 1, 1998 - Apr 30, 2012
      Role: Principal Investigator
      NIH/NIGMS R01GM053835Aug 1, 1996 - Jul 31, 2001
      Role: Principal Investigator
      NIH/NICHD R01HD029275Apr 1, 1992 - Aug 31, 1997
      Role: Principal Investigator
      NIH/NIAID R21AI024285Apr 1, 1988 - Aug 31, 2001
      Role: Principal Investigator
      NIH/NIAID R01AI024285Apr 1, 1988 - May 31, 1999
      Role: Principal Investigator
      NIH/NIAID R01AI019863Sep 1, 1982 - Apr 30, 1997
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin F, Fokin VV, Sharpless KB, Eckmann L. Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17564-9. PMID: 24101497; PMCID: PMC3808650.
      2. Jantscher-Krenn E, Lauwaet T, Bliss LA, Reed SL, Gillin F, Bode L. Human milk oligosaccharides reduce Entamoeba histolytica attachment and cytotoxicity in vitro. Br J Nutr. 2012 Nov 28; 108(10):1839-46. PMID: 22264879.
        View in: PubMed
      3. Jenikova G, Hruz P, Andersson MK, Tejman-Yarden N, Ferreira PC, Andersen YS, Davids BJ, Gillin F, Svärd SG, Curtiss R, Eckmann L. ?1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model. Vaccine. 2011 Nov 28; 29(51):9529-37. PMID: 22001876; PMCID: PMC4045459.
      4. Tejman-Yarden N, Millman M, Lauwaet T, Davids BJ, Gillin F, Dunn L, Upcroft JA, Miyamoto Y, Eckmann L. Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia. Antimicrob Agents Chemother. 2011 Oct; 55(10):4643-51. PMID: 21825286; PMCID: PMC3186953.
      5. Dunn LA, Burgess AG, Krauer KG, Eckmann L, Vanelle P, Crozet MD, Gillin F, Upcroft P, Upcroft JA. A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro. Int J Antimicrob Agents. 2010 Jul; 36(1):37-42. PMID: 20456926; PMCID: PMC3103471.
      6. Lauwaet T, Andersen Y, Van de Ven L, Eckmann L, Gillin F. Rapid detachment of Giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone formononetin. J Antimicrob Chemother. 2010 Mar; 65(3):531-4. PMID: 20067984; PMCID: PMC2818108.
      7. Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin F, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L. Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. J Med Chem. 2009 Jul 09; 52(13):4038-53. PMID: 19480409; PMCID: PMC2766634.
      8. Ringqvist E, Palm JE, Skarin H, Hehl AB, Weiland M, Davids BJ, Reiner DS, Griffiths WJ, Eckmann L, Gillin F, Svärd SG. Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells. Mol Biochem Parasitol. 2008 Jun; 159(2):85-91. PMID: 18359106; PMCID: PMC3658456.
      9. Davids BJ, Palm JE, Housley MP, Smith JR, Andersen YS, Martin MG, Hendrickson BA, Johansen FE, Svärd SG, Gillin F, Eckmann L. Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia. J Immunol. 2006 Nov 01; 177(9):6281-90. PMID: 17056558.
        View in: PubMed
      10. Andersen YS, Gillin F, Eckmann L. Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp. Infect Immun. 2006 Apr; 74(4):2473-6. PMID: 16552082; PMCID: PMC1418922.
      11. Reiner DS, Hetsko ML, Meszaros JG, Sun CH, Morrison HG, Brunton LL, Gillin F. Calcium signaling in excystation of the early diverging eukaryote, Giardia lamblia. J Biol Chem. 2003 Jan 24; 278(4):2533-40. PMID: 12397071.
        View in: PubMed
      12. Langford TD, Housley MP, Boes M, Chen J, Kagnoff MF, Gillin F, Eckmann L. Central importance of immunoglobulin A in host defense against Giardia spp. Infect Immun. 2002 Jan; 70(1):11-8. PMID: 11748158; PMCID: PMC127595.
      13. Eckmann L, Gillin F. Microbes and microbial toxins: paradigms for microbial-mucosal interactions I. Pathophysiological aspects of enteric infections with the lumen-dwelling protozoan pathogen Giardia lamblia. Am J Physiol Gastrointest Liver Physiol. 2001 Jan; 280(1):G1-6. PMID: 11123191.
        View in: PubMed
      14. Eckmann L, Laurent F, Langford TD, Hetsko ML, Smith JR, Kagnoff MF, Gillin F. Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia. J Immunol. 2000 Feb 01; 164(3):1478-87. PMID: 10640765.
        View in: PubMed
      15. Hetsko ML, McCaffery JM, Svärd SG, Meng TC, Que X, Gillin F. Cellular and transcriptional changes during excystation of Giardia lamblia in vitro. Exp Parasitol. 1998 Mar; 88(3):172-83. PMID: 9562420.
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      16. Das S, Schteingart CD, Hofmann AF, Reiner DS, Aley SB, Gillin F. Giardia lamblia: evidence for carrier-mediated uptake and release of conjugated bile acids. Exp Parasitol. 1997 Oct; 87(2):133-41. PMID: 9326888.
        View in: PubMed
      17. Que X, Svärd SG, Meng TC, Hetsko ML, Aley SB, Gillin F. Developmentally regulated transcripts and evidence of differential mRNA processing in Giardia lamblia. Mol Biochem Parasitol. 1996 Oct 18; 81(1):101-10. PMID: 8892309.
        View in: PubMed
      18. Reed S, Bouvier J, Pollack AS, Engel JC, Brown M, Hirata K, Que X, Eakin A, Hagblom P, Gillin F. Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene. J Clin Invest. 1993 Apr; 91(4):1532-40. PMID: 8473498; PMCID: PMC288129.
      19. Reed S, Bouvier J, Hirata K, Que X, Pollack AS, Engel JC, Gillin F, McKerrow JH. A unique cysteine proteinase gene of pathogenic Entamoeba histolytica correlates with virulence. Arch Med Res. 1992; 23(2):181-2. PMID: 1340288.
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      20. Gillin F, Hagblom P, Harwood J, Aley SB, Reiner DS, McCaffery M, So M, Guiney DG. Isolation and expression of the gene for a major surface protein of Giardia lamblia. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4463-7. PMID: 2352929; PMCID: PMC54135.
      21. Gillin F, Boucher SE, Rossi SS, Reiner DS. Giardia lamblia: the roles of bile, lactic acid, and pH in the completion of the life cycle in vitro. Exp Parasitol. 1989 Aug; 69(2):164-74. PMID: 2753120.
        View in: PubMed
      22. Deguchi M, Gillin F, Gigli I. Mechanism of killing of Giardia lamblia trophozoites by complement. J Clin Invest. 1987 May; 79(5):1296-302. PMID: 3646264.
        View in: PubMed
      23. Reed SL, Gault M, Gillin F, Gigli I, Braude AI, Curd JG, Sargeaunt PG. Interaction of pathogenic and nonpathogenic Entamoeba histolytica with human complement. Arch Invest Med (Mex). 1987 Apr-Jun; 18(2):141-9. PMID: 2889433.
        View in: PubMed
      24. Gillin F, Gault MJ, Hofmann AF, Gurantz D, Sauch JF. Biliary lipids support serum-free growth of Giardia lamblia. Infect Immun. 1986 Sep; 53(3):641-5. PMID: 3744557; PMCID: PMC260841.
      25. Reed SL, Curd JG, Gigli I, Gillin F, Braude AI. Activation of complement by pathogenic and nonpathogenic Entamoeba histolytica. J Immunol. 1986 Mar 15; 136(6):2265-70. PMID: 2869084.
        View in: PubMed
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