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Susan Kaech

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0932
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    (PQ1) Lipid Metabolism, Inflammation, and T cell Dysfunction in HIV-associated Cancer
    NIH/NCI R01CA206483Jun 1, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Discovery of NR4A1/2 ligands controlling tissue-resident memory T (Trm) cells
    NIH/NIAID R21AI131015Jan 1, 2017 - Dec 31, 2018
    Role: Co-Principal Investigator
    Cellular Mechanisms of Viral Control
    NIH/NIAID R01AI123864Mar 15, 2016 - Feb 28, 2021
    Role: Co-Principal Investigator
    Targeting the Immune System in Mouse Models of Lung Adenocarcinoma
    NIH/NCI R01CA195720Apr 16, 2015 - Mar 31, 2018
    Role: Co-Principal Investigator
    The role of STAT3 in effector and memory CD8 T cell longevity and metabolism
    NIH/NIAID R21AI097767Feb 1, 2012 - Jan 31, 2015
    Role: Principal Investigator
    iCyt Reflection Cell Sorter
    NIH/NCRR S10RR029602Dec 10, 2009 - Dec 9, 2011
    Role: Principal Investigator
    Transcriptional control of IL-7 receptor (IL-7R) in T cells
    NIH/FIC R03TW008208Aug 10, 2009 - May 31, 2013
    Role: Principal Investigator
    Control of Effector and Memory T Cell Development by Inflammatory Signals
    NIH/NIAID R01AI074699Jun 25, 2009 - May 31, 2014
    Role: Principal Investigator
    Determining how adjuvants alter effector and memory T cells during vaccination
    NIH/NIAID R21AI081150May 22, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Control of Terminal Differentiation of Effector and Memory T Cells by Blimp-1
    NIH/NIAID R21AI077075Aug 15, 2007 - Jul 31, 2009
    Role: Principal Investigator
    Regulation of memory CD8 T cell development
    NIH/NIAID R37AI066232May 1, 2005 - Jan 31, 2023
    Role: Principal Investigator
    Regulation of memory CD8 T cell development
    NIH/NIAID R01AI066232May 1, 2005 - Oct 31, 2013
    Role: Principal Investigator
    Priming of Memory and Effector CD4 T Cells
    NIH/NCI R01CA038350Mar 1, 1984 - Dec 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fan MY, Low JS, Tanimine N, Finn KK, Priyadharshini B, Germana SK, Kaech SM, Turka LA. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep. 2018 Oct 30; 25(5):1204-1213.e4. PMID: 30380412.
      View in: PubMed
    2. Kaech SM. T-bet in Tfh cells: Now you see me, now you don't. J Exp Med. 2018 Nov 05; 215(11):2697-2698. PMID: 30337467.
      View in: PubMed
    3. Arojo OA, Ouyang X, Liu D, Meng T, Kaech SM, Pereira JP, Su B. Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression. J Immunol. 2018 Aug 01; 201(3):908-915. PMID: 29934471.
      View in: PubMed
    4. Pereira FV, Melo ACL, Low JS, de Castro ÍA, Braga TT, Almeida DC, Batista de Lima AGU, Hiyane MI, Correa-Costa M, Andrade-Oliveira V, Origassa CST, Pereira RM, Kaech SM, Rodrigues EG, Câmara NOS. Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response. Oncotarget. 2018 May 25; 9(40):25808-25825. PMID: 29899823.
      View in: PubMed
    5. Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA. KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 2018 Apr 17; 48(4):716-729.e8. PMID: 29625895.
      View in: PubMed
    6. Gettinger SN, Wurtz A, Goldberg SB, Rimm D, Schalper K, Kaech S, Kavathas P, Chiang A, Lilenbaum R, Zelterman D, Politi K, Herbst RS. Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non-Small Cell Lung Cancer. J Thorac Oncol. 2018 Jun; 13(6):831-839. PMID: 29578107.
      View in: PubMed
    7. Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates. J Exp Med. 2018 Apr 02; 215(4):1153-1168. PMID: 29449309.
      View in: PubMed
    8. Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. Correction: STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med. 2018 Mar 05; 215(3):999. PMID: 29440270.
      View in: PubMed
    9. Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, Du VY, Wang JX, Damsky W, Kuhlmann AL, Sher JW, Bosenberg M, Miller-Jensen K, Kaech SM. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med. 2018 Mar 05; 215(3):877-893. PMID: 29436395.
      View in: PubMed
    10. Low JS, Kaech SM. Trials and Tribble-ations of tissue TRM cells. Nat Immunol. 2018 Feb; 19(2):102-103. PMID: 29348504.
      View in: PubMed
    11. Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med. 2018 Jan 02; 215(1):337-355. PMID: 29212666.
      View in: PubMed
    12. Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J. Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Sci Immunol. 2017 Oct 20; 2(16). PMID: 29054998.
      View in: PubMed
    13. Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Cancer Discov. 2017 12; 7(12):1420-1435. PMID: 29025772.
      View in: PubMed
    14. Yeon SM, Halim L, Chandele A, Perry CJ, Kim SH, Kim SU, Byun Y, Yuk SH, Kaech SM, Jung YW. IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways. Sci Rep. 2017 Sep 11; 7(1):11155. PMID: 28894184.
      View in: PubMed
    15. Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. PLoS Pathog. 2017 Aug; 13(8):e1006544. PMID: 28827827.
      View in: PubMed
    16. Roberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. J Immunol. 2017 08 15; 199(4):1250-1260. PMID: 28701508.
      View in: PubMed
    17. Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell Melanoma Res. 2017 07; 30(4):428-435. PMID: 28379630.
      View in: PubMed
    18. Buck MD, Sowell RT, Kaech SM, Pearce EL. Metabolic Instruction of Immunity. Cell. 2017 05 04; 169(4):570-586. PMID: 28475890.
      View in: PubMed
    19. Ho PC, Kaech SM. Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries. Curr Opin Immunol. 2017 Jun; 46:38-44. PMID: 28458087.
      View in: PubMed
    20. Gray SM, Amezquita RA, Guan T, Kleinstein SH, Kaech SM. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency. Immunity. 2017 04 18; 46(4):596-608. PMID: 28410989.
      View in: PubMed
    21. Hajek M, Sewell A, Kaech S, Burtness B, Yarbrough WG, Issaeva N. TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. Cancer. 2017 05 15; 123(10):1778-1790. PMID: 28295222.
      View in: PubMed
    22. Amezquita RA, Kaech SM. Immunology: The chronicles of T-cell exhaustion. Nature. 2017 03 09; 543(7644):190-191. PMID: 28225757.
      View in: PubMed
    23. Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ. IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci Immunol. 2016 Oct; 1(5). PMID: 28713870.
      View in: PubMed
    24. Adams NM, O'Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC. NK Cell Responses Redefine Immunological Memory. J Immunol. 2016 10 15; 197(8):2963-2970. PMID: 27824591.
      View in: PubMed
    25. Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. J Clin Invest. 2016 10 03; 126(10):3905-3916. PMID: 27617863.
      View in: PubMed
    26. Sowell RT, Kaech SM. Probing the Diversity of T Cell Dysfunction in Cancer. Cell. 2016 Sep 08; 166(6):1362-1364. PMID: 27610560.
      View in: PubMed
    27. Kritikou JS, Dahlberg CI, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H, Westerberg LS. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016 08 01; 6:30636. PMID: 27477778.
      View in: PubMed
    28. Jung YW, Kim HG, Perry CJ, Kaech SM. CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8278-83. PMID: 27385825; PMCID: PMC4961181 [Available on 01/19/17].
    29. Garyu JW, Uduman M, Stewart A, Rui J, Deng S, Shenson J, Staron MM, Kaech SM, Kleinstein SH, Herold KC. Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE. J Biol Chem. 2016 May 20; 291(21):11230-40. PMID: 26994137; PMCID: PMC4900270 [Available on 05/20/17].
    30. Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A. A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet. Nat Immunol. 2016 Apr; 17(4):422-32. PMID: 26950239.
      View in: PubMed
    31. Laidlaw BJ, Craft JE, Kaech SM. The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nat Rev Immunol. 2016 Feb; 16(2):102-11. PMID: 26781939; PMCID: PMC4860014 [Available on 02/01/17].
    32. Dominguez CX, Amezquita RA, Guan T, Marshall HD, Joshi NS, Kleinstein SH, Kaech SM. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. J Exp Med. 2015 Nov 16; 212(12):2041-56. PMID: 26503446; PMCID: PMC4647261.
    33. Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20; 43(4):690-702. PMID: 26410627; PMCID: PMC4618086 [Available on 10/20/16].
    34. Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Sep 10; 162(6):1217-28. PMID: 26321681; PMCID: PMC4567953.
    35. Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat Immunol. 2015 Aug; 16(8):871-9. PMID: 26147684.
      View in: PubMed
    36. Cui G, Staron MM, Gray SM, Ho PC, Amezquita RA, Wu J, Kaech SM. IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity. Cell. 2015 May 07; 161(4):750-61. PMID: 25957683; PMCID: PMC4704440.
    37. Chen JH, Perry CJ, Tsui YC, Staron MM, Parish IA, Dominguez CX, Rosenberg DW, Kaech SM. Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. Nat Med. 2015 Apr; 21(4):327-34. PMID: 25799228; PMCID: PMC4505619.
    38. Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015 Feb 12; 160(4):745-758. PMID: 25662011.
      View in: PubMed
    39. West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015 Apr 23; 520(7548):553-7. PMID: 25642965; PMCID: PMC4409480.
    40. Hu Y, Lee YT, Kaech SM, Garvy B, Cauley LS. Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells. J Immunol. 2015 Mar 01; 194(5):2407-14. PMID: 25637015; PMCID: PMC4337487.
    41. Marshall HD, Ray JP, Laidlaw BJ, Zhang N, Gawande D, Staron MM, Craft J, Kaech SM. The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. Elife. 2015 Jan 08; 4:e04851. PMID: 25569154; PMCID: PMC4337607.
    42. Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging (Albany NY). 2015 Jan; 7(1):38-52. PMID: 25596819; PMCID: PMC4356402.
    43. Staron MM, Gray SM, Marshall HD, Parish IA, Chen JH, Perry CJ, Cui G, Li MO, Kaech SM. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. Immunity. 2014 Nov 20; 41(5):802-14. PMID: 25464856.
      View in: PubMed
    44. Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis. 2015 Apr 01; 211(7):1174-84. PMID: 25367297; PMCID: PMC4366602.
    45. Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AH, Kaech SM, Blander JM, van Gisbergen K, Amsen D. A central role for Notch in effector CD8(+) T cell differentiation. Nat Immunol. 2014 Dec; 15(12):1143-51. PMID: 25344724; PMCID: PMC4232996.
    46. Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity. 2014 Oct 16; 41(4):633-45. PMID: 25308332.
      View in: PubMed
    47. Gray SM, Kaech SM, Staron MM. The interface between transcriptional and epigenetic control of effector and memory CD8? T-cell differentiation. Immunol Rev. 2014 Sep; 261(1):157-68. PMID: 25123283; PMCID: PMC4267690.
    48. Shaw PJ, Weidinger C, Vaeth M, Luethy K, Kaech SM, Feske S. CD4? and CD8? T cell-dependent antiviral immunity requires STIM1 and STIM2. J Clin Invest. 2014 Oct; 124(10):4549-63. PMID: 25157823; PMCID: PMC4191007.
    49. Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. T-cell TGF-ß signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3458-66. PMID: 25082897; PMCID: PMC4143044.
    50. Marshall HD, Kaech SM. Regulating the diverse outcomes of interferon's interference. Trends Immunol. 2014 Aug; 35(8):353-4. PMID: 25052591; PMCID: PMC4267687.
    51. Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J Clin Invest. 2014 Aug; 124(8):3455-68. PMID: 25003188; PMCID: PMC4109559.
    52. Ho PC, Kaech SM. BRAF-targeted therapy alters the functions of intratumoral CD4+ T cells to inhibit melanoma progression. Oncoimmunology. 2014; 3:e29126. PMID: 25083331.
      View in: PubMed
    53. Ho PC, Meeth KM, Tsui YC, Srivastava B, Bosenberg MW, Kaech SM. Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFN?. Cancer Res. 2014 Jun 15; 74(12):3205-17. PMID: 24736544; PMCID: PMC4063281.
    54. Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH, Kaech SM. TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. J Immunol. 2014 May 01; 192(9):4221-32. PMID: 24659688; PMCID: PMC4071140.
    55. Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity. 2014 Mar 20; 40(3):367-77. PMID: 24631156; PMCID: PMC3992517.
    56. Kaech SM. Celebrating diversity in memory T cells. J Immunol. 2014 Feb 01; 192(3):837-9. PMID: 24443505; PMCID: PMC4269237.
    57. Slütter B, Pewe LL, Kaech SM, Harty JT. Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. Immunity. 2013 Nov 14; 39(5):939-48. PMID: 24238342; PMCID: PMC3872058.
    58. Shin HM, Kapoor V, Guan T, Kaech SM, Welsh RM, Berg LJ. Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection. Immunity. 2013 Oct 17; 39(4):661-75. PMID: 24120360; PMCID: PMC3808842.
    59. Marshall HD, Kaech SM. Generating CD8 T cell heterogeneity: attack of the clones. Immunity. 2013 Aug 22; 39(2):203-5. PMID: 23973217; PMCID: PMC4382630.
    60. Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech SM, Weaver CT, Flavell RA, Zhao L, Yao Z, Yin Z. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. J Leukoc Biol. 2013 Dec; 94(6):1103-12. PMID: 23772040.
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    61. Henao-Mejia J, Williams A, Goff LA, Staron M, Licona-Limón P, Kaech SM, Nakayama M, Rinn JL, Flavell RA. The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity. 2013 May 23; 38(5):984-97. PMID: 23623381; PMCID: PMC3738211.
    62. Kaech SM, Cui W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol. 2012 Nov; 12(11):749-61. PMID: 23080391; PMCID: PMC4137483.
    63. D'Souza AD, Parish IA, Krause DS, Kaech SM, Shadel GS. Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. Mol Ther. 2013 Jan; 21(1):42-8. PMID: 23011031; PMCID: PMC3538311.
    64. Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials. 2012 Jun; 33(19):4957-64. PMID: 22484047.
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    65. Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1210-5. PMID: 22167808; PMCID: PMC3268324.
    66. Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity. 2011 Nov 23; 35(5):792-805. PMID: 22118527; PMCID: PMC3431922.
    67. Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity. 2011 Oct 28; 35(4):633-46. PMID: 22018471.
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    68. Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW, Kaech SM. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. J Immunol. 2011 Oct 15; 187(8):4068-76. PMID: 21930973; PMCID: PMC3991478.
    69. Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD. Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood. 2011 Nov 24; 118(22):5965-76. PMID: 21917752; PMCID: PMC3228506.
    70. D'Souza AD, Parish IA, McKay SE, Kaech SM, Shadel GS. Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. Am J Pathol. 2011 Jun; 178(6):2740-51. PMID: 21641396; PMCID: PMC3124231.
    71. Parish IA, Kaech SM. IL-7 knocks the socs off chronic viral infection. Cell. 2011 Feb 18; 144(4):467-8. PMID: 21335230; PMCID: PMC4380280.
    72. Jung YW, Rutishauser RL, Joshi NS, Haberman AM, Kaech SM. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J Immunol. 2010 Nov 01; 185(9):5315-25. PMID: 20921525; PMCID: PMC4267692.
    73. Jung YW, Kaech SM. Like parent, like child: inheritance of effector CD8+ T cell traits. Immunity. 2010 Sep 24; 33(3):296-8. PMID: 20870171.
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    74. Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16601-6. PMID: 20823247; PMCID: PMC2944719.
    75. Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. J Immunol. 2010 Sep 01; 185(5):2989-97. PMID: 20660705; PMCID: PMC3753007.
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