Loading...

Susan Kaech

Title(s)Adjunct Professor, Molecular Biology
SchoolAcademic Aff
Address9500 Gilman Drive #0932
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic heterogeneity of tissue resident memory T cells in the liver
    NIH/NIAID R21AI151562Mar 6, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Metabolic regulation of epigenetic states in CD8 T cell exhaustion
    NIH/NIAID R21AI151986Mar 5, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunity
    NIH/NCI R01CA240909Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Understanding and Overcoming Resistance to Cancer Immunotherapy Due to Defective Antigen Presentation
    NIH/NCI R01CA230275Feb 6, 2019 - Jan 31, 2024
    Role: Co-Principal Investigator
    (PQ5) Mitochondrial Heterogeneity in Melanoma Tumor and Immune Responses
    NIH/NCI R01CA216101Sep 1, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    (PQ1) Lipid Metabolism, Inflammation, and T cell Dysfunction in HIV-associated Cancer
    NIH/NCI R01CA206483Jun 1, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Discovery of NR4A1/2 ligands controlling tissue-resident memory T (Trm) cells
    NIH/NIAID R21AI131015Jan 1, 2017 - Dec 31, 2018
    Role: Co-Principal Investigator
    Cellular Mechanisms of Viral Control
    NIH/NIAID R01AI123864Mar 15, 2016 - Feb 28, 2021
    Role: Co-Principal Investigator
    Targeting the Immune System in Mouse Models of Lung Adenocarcinoma
    NIH/NCI R01CA195720Apr 16, 2015 - Mar 31, 2018
    Role: Co-Principal Investigator
    Regulation of memory CD8 T cell development
    NIH/NIAID R37AI066232Feb 1, 2013 - Jan 31, 2023
    Role: Principal Investigator
    The role of STAT3 in effector and memory CD8 T cell longevity and metabolism
    NIH/NIAID R21AI097767Feb 1, 2012 - Jan 31, 2015
    Role: Principal Investigator
    Regulation of memory CD8 T cell development
    NIH/NIAID R01AI066232Aug 1, 2010 - Oct 31, 2013
    Role: Principal Investigator
    iCyt Reflection Cell Sorter
    NIH/NCRR S10RR029602Dec 10, 2009 - Dec 9, 2011
    Role: Principal Investigator
    Transcriptional control of IL-7 receptor (IL-7R) in T cells
    NIH/FIC R03TW008208Aug 10, 2009 - May 31, 2013
    Role: Principal Investigator
    Control of Effector and Memory T Cell Development by Inflammatory Signals
    NIH/NIAID R01AI074699Jun 25, 2009 - May 31, 2014
    Role: Principal Investigator
    Determining how adjuvants alter effector and memory T cells during vaccination
    NIH/NIAID R21AI081150May 22, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Control of Terminal Differentiation of Effector and Memory T Cells by Blimp-1
    NIH/NIAID R21AI077075Aug 15, 2007 - Jul 31, 2009
    Role: Principal Investigator
    Priming of Memory and Effector CD4 T Cells
    NIH/NCI R01CA038350Mar 1, 1984 - Jan 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. J Exp Med. 2020 Aug 03; 217(8). Low JS, Farsakoglu Y, Amezcua Vesely MC, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. PMID: 32525985.
      View in: PubMed   Mentions:    Fields:    
    2. Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations. Cancer Res. 2020 May 15; 80(10):2017-2030. Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech SM, Unni AM, Homer R, Lockwood WW, Michor F, Goldberg SB, Lemmon MA, Smith PD, Cross DAE, Politi K. PMID: 32193290.
      View in: PubMed   Mentions:    Fields:    
    3. Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults. J Immunol. 2020 Mar 15; 204(6):1661-1673. Avey S, Mohanty S, Chawla DG, Meng H, Bandaranayake T, Ueda I, Zapata HJ, Park K, Blevins TP, Tsang S, Belshe RB, Kaech SM, Shaw AC, Kleinstein SH. PMID: 32060136.
      View in: PubMed   Mentions:    Fields:    
    4. Reinvigorating NIH Grant Peer Review. Immunity. 2020 01 14; 52(1):1-3. Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, Krummel M, Pepper M, Rothlin CV, Wherry EJ. PMID: 31940266.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Mitochondrial DNA Stress Signalling Protects the Nuclear Genome. Nat Metab. 2019 Dec; 1(12):1209-1218. Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. PMID: 32395698.
      View in: PubMed   Mentions:
    6. T Cell Metabolism in a State of Flux. Immunity. 2019 11 19; 51(5):783-785. Varanasi SK, Ma S, Kaech SM. PMID: 31747577.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth. Oncogene. 2020 01; 39(3):560-573. Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR, Han W, Sherwin RS, Nie Y, Yang X. PMID: 31501520.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell. 2019 09 19; 179(1):236-250.e18. Harel M, Ortenberg R, Varanasi SK, Mangalhara KC, Mardamshina M, Markovits E, Baruch EN, Tripple V, Arama-Chayoth M, Greenberg E, Shenoy A, Ayasun R, Knafo N, Xu S, Anafi L, Yanovich-Arad G, Barnabas GD, Ashkenazi S, Besser MJ, Schachter J, Bosenberg M, Shadel GS, Barshack I, Kaech SM, Markel G, Geiger T. PMID: 31495571.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Tick-TOX, it's time for T cell exhaustion. Nat Immunol. 2019 09; 20(9):1092-1094. Mann TH, Kaech SM. PMID: 31427776.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment. Oncotarget. 2019 Jul 16; 10(44):4532-4545. Gaffney SG, Perry EB, Chen PM, Greenstein A, Kaech SM, Townsend JP. PMID: 31360302.
      View in: PubMed   Mentions:    Fields:    
    11. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. J Immunother Cancer. 2019 07 10; 7(1):172. Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, Kaech S, Politi K. PMID: 31291990.
      View in: PubMed   Mentions:    Fields:    
    12. A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPa expression. Nat Commun. 2019 02 15; 10(1):794. Myers LM, Tal MC, Torrez Dulgeroff LB, Carmody AB, Messer RJ, Gulati G, Yiu YY, Staron MM, Angel CL, Sinha R, Markovic M, Pham EA, Fram B, Ahmed A, Newman AM, Glenn JS, Davis MM, Kaech SM, Weissman IL, Hasenkrug KJ. PMID: 30770827.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep. 2018 10 30; 25(5):1204-1213.e4. Fan MY, Low JS, Tanimine N, Finn KK, Priyadharshini B, Germana SK, Kaech SM, Turka LA. PMID: 30380412.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. T-bet in Tfh cells: Now you see me, now you don't. J Exp Med. 2018 11 05; 215(11):2697-2698. Kaech SM. PMID: 30337467.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    15. A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers. Nat Commun. 2018 08 10; 9(1):3196. Gettinger SN, Choi J, Mani N, Sanmamed MF, Datar I, Sowell R, Du VY, Kaftan E, Goldberg S, Dong W, Zelterman D, Politi K, Kavathas P, Kaech S, Yu X, Zhao H, Schlessinger J, Lifton R, Rimm DL, Chen L, Herbst RS, Schalper KA. PMID: 30097571.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression. J Immunol. 2018 08 01; 201(3):908-915. Arojo OA, Ouyang X, Liu D, Meng T, Kaech SM, Pereira JP, Su B. PMID: 29934471.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response. Oncotarget. 2018 May 25; 9(40):25808-25825. Pereira FV, Melo ACL, Low JS, de Castro ÍA, Braga TT, Almeida DC, Batista de Lima AGU, Hiyane MI, Correa-Costa M, Andrade-Oliveira V, Origassa CST, Pereira RM, Kaech SM, Rodrigues EG, Câmara NOS. PMID: 29899823.
      View in: PubMed   Mentions: 5     Fields:    
    18. KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 2018 04 17; 48(4):716-729.e8. Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA. PMID: 29625895.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non-Small Cell Lung Cancer. J Thorac Oncol. 2018 06; 13(6):831-839. Gettinger SN, Wurtz A, Goldberg SB, Rimm D, Schalper K, Kaech S, Kavathas P, Chiang A, Lilenbaum R, Zelterman D, Politi K, Herbst RS. PMID: 29578107.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates. J Exp Med. 2018 04 02; 215(4):1153-1168. Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM. PMID: 29449309.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. Correction: STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med. 2018 03 05; 215(3):999. Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. PMID: 29440270.
      View in: PubMed   Mentions:    Fields:    
    22. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med. 2018 03 05; 215(3):877-893. Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, Du VY, Wang JX, Damsky W, Kuhlmann AL, Sher JW, Bosenberg M, Miller-Jensen K, Kaech SM. PMID: 29436395.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    23. Trials and Tribble-ations of tissue TRM cells. Nat Immunol. 2018 02; 19(2):102-103. Low JS, Kaech SM. PMID: 29348504.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med. 2018 01 02; 215(1):337-355. Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. PMID: 29212666.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    25. Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Sci Immunol. 2017 10 20; 2(16). Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J. PMID: 29054998.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    26. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Cancer Discov. 2017 12; 7(12):1420-1435. Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K. PMID: 29025772.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    27. IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways. Sci Rep. 2017 09 11; 7(1):11155. Yeon SM, Halim L, Chandele A, Perry CJ, Kim SH, Kim SU, Byun Y, Yuk SH, Kaech SM, Jung YW. PMID: 28894184.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. PLoS Pathog. 2017 Aug; 13(8):e1006544. Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ. PMID: 28827827.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. J Immunol. 2017 08 15; 199(4):1250-1260. Roberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V. PMID: 28701508.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell Melanoma Res. 2017 07; 30(4):428-435. Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. PMID: 28379630.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    31. Metabolic Instruction of Immunity. Cell. 2017 05 04; 169(4):570-586. Buck MD, Sowell RT, Kaech SM, Pearce EL. PMID: 28475890.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    32. Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries. Curr Opin Immunol. 2017 Jun; 46:38-44. Ho PC, Kaech SM. PMID: 28458087.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    33. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency. Immunity. 2017 04 18; 46(4):596-608. Gray SM, Amezquita RA, Guan T, Kleinstein SH, Kaech SM. PMID: 28410989.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. Cancer. 2017 05 15; 123(10):1778-1790. Hajek M, Sewell A, Kaech S, Burtness B, Yarbrough WG, Issaeva N. PMID: 28295222.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    35. Immunology: The chronicles of T-cell exhaustion. Nature. 2017 03 09; 543(7644):190-191. Amezquita RA, Kaech SM. PMID: 28225757.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    36. IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci Immunol. 2016 Oct; 1(5). Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ. PMID: 28713870.
      View in: PubMed   Mentions: 3     Fields:    
    37. NK Cell Responses Redefine Immunological Memory. J Immunol. 2016 10 15; 197(8):2963-2970. Adams NM, O'Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC. PMID: 27824591.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. J Clin Invest. 2016 10 03; 126(10):3905-3916. Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV. PMID: 27617863.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    39. Probing the Diversity of T Cell Dysfunction in Cancer. Cell. 2016 Sep 08; 166(6):1362-1364. Sowell RT, Kaech SM. PMID: 27610560.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    40. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016 08 01; 6:30636. Kritikou JS, Dahlberg CI, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H, Westerberg LS. PMID: 27477778.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    41. CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8278-83. Jung YW, Kim HG, Perry CJ, Kaech SM. PMID: 27385825.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    42. Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE. J Biol Chem. 2016 May 20; 291(21):11230-40. Garyu JW, Uduman M, Stewart A, Rui J, Deng S, Shenson J, Staron MM, Kaech SM, Kleinstein SH, Herold KC. PMID: 26994137.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    43. A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet. Nat Immunol. 2016 Apr; 17(4):422-32. Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A. PMID: 26950239.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    44. The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nat Rev Immunol. 2016 Feb; 16(2):102-11. Laidlaw BJ, Craft JE, Kaech SM. PMID: 26781939.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCellsPHPublic Health
    45. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. J Exp Med. 2015 Nov 16; 212(12):2041-56. Dominguez CX, Amezquita RA, Guan T, Marshall HD, Joshi NS, Kleinstein SH, Kaech SM. PMID: 26503446.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    46. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20; 43(4):690-702. Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J. PMID: 26410627.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    47. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Sep 10; 162(6):1217-28. Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. PMID: 26321681.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    48. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat Immunol. 2015 Aug; 16(8):871-9. Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. PMID: 26147684.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    49. IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity. Cell. 2015 May 07; 161(4):750-61. Cui G, Staron MM, Gray SM, Ho PC, Amezquita RA, Wu J, Kaech SM. PMID: 25957683.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    50. Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. Nat Med. 2015 Apr; 21(4):327-34. Chen JH, Perry CJ, Tsui YC, Staron MM, Parish IA, Dominguez CX, Rosenberg DW, Kaech SM. PMID: 25799228.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    51. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015 Feb 12; 160(4):745-758. Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. PMID: 25662011.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    52. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015 Apr 23; 520(7548):553-7. West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. PMID: 25642965.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansAnimalsCells
    53. Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells. J Immunol. 2015 Mar 01; 194(5):2407-14. Hu Y, Lee YT, Kaech SM, Garvy B, Cauley LS. PMID: 25637015.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    54. The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. Elife. 2015 Jan 08; 4:e04851. Marshall HD, Ray JP, Laidlaw BJ, Zhang N, Gawande D, Staron MM, Craft J, Kaech SM. PMID: 25569154.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    55. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging (Albany NY). 2015 Jan; 7(1):38-52. Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC. PMID: 25596819.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCellsPHPublic Health
    56. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. Immunity. 2014 Nov 20; 41(5):802-14. Staron MM, Gray SM, Marshall HD, Parish IA, Chen JH, Perry CJ, Cui G, Li MO, Kaech SM. PMID: 25464856.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    57. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis. 2015 Apr 01; 211(7):1174-84. Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC. PMID: 25367297.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsPHPublic Health
    58. A central role for Notch in effector CD8(+) T cell differentiation. Nat Immunol. 2014 Dec; 15(12):1143-51. Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AH, Kaech SM, Blander JM, van Gisbergen K, Amsen D. PMID: 25344724.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    59. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity. 2014 Oct 16; 41(4):633-45. Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM. PMID: 25308332.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    60. The interface between transcriptional and epigenetic control of effector and memory CD8? T-cell differentiation. Immunol Rev. 2014 Sep; 261(1):157-68. Gray SM, Kaech SM, Staron MM. PMID: 25123283.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    61. CD4? and CD8? T cell-dependent antiviral immunity requires STIM1 and STIM2. J Clin Invest. 2014 Oct; 124(10):4549-63. Shaw PJ, Weidinger C, Vaeth M, Luethy K, Kaech SM, Feske S. PMID: 25157823.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    62. T-cell TGF-ß signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3458-66. Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. PMID: 25082897.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    63. Regulating the diverse outcomes of interferon's interference. Trends Immunol. 2014 Aug; 35(8):353-4. Marshall HD, Kaech SM. PMID: 25052591.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    64. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J Clin Invest. 2014 Aug; 124(8):3455-68. Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM. PMID: 25003188.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    65. BRAF-targeted therapy alters the functions of intratumoral CD4+ T cells to inhibit melanoma progression. Oncoimmunology. 2014; 3:e29126. Ho PC, Kaech SM. PMID: 25083331.
      View in: PubMed   Mentions:
    66. Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFN?. Cancer Res. 2014 Jun 15; 74(12):3205-17. Ho PC, Meeth KM, Tsui YC, Srivastava B, Bosenberg MW, Kaech SM. PMID: 24736544.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    67. TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. J Immunol. 2014 May 01; 192(9):4221-32. Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH, Kaech SM. PMID: 24659688.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    68. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity. 2014 Mar 20; 40(3):367-77. Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J. PMID: 24631156.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    69. Celebrating diversity in memory T cells. J Immunol. 2014 Feb 01; 192(3):837-9. Kaech SM. PMID: 24443505.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    70. Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. Immunity. 2013 Nov 14; 39(5):939-48. Slütter B, Pewe LL, Kaech SM, Harty JT. PMID: 24238342.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCellsPHPublic Health
    71. Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection. Immunity. 2013 Oct 17; 39(4):661-75. Shin HM, Kapoor V, Guan T, Kaech SM, Welsh RM, Berg LJ. PMID: 24120360.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    72. Generating CD8 T cell heterogeneity: attack of the clones. Immunity. 2013 Aug 22; 39(2):203-5. Marshall HD, Kaech SM. PMID: 23973217.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    73. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. J Leukoc Biol. 2013 Dec; 94(6):1103-12. Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech SM, Weaver CT, Flavell RA, Zhao L, Yao Z, Yin Z. PMID: 23772040.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    74. The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity. 2013 May 23; 38(5):984-97. Henao-Mejia J, Williams A, Goff LA, Staron M, Licona-Limón P, Kaech SM, Nakayama M, Rinn JL, Flavell RA. PMID: 23623381.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    75. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol. 2012 Nov; 12(11):749-61. Kaech SM, Cui W. PMID: 23080391.
      View in: PubMed   Mentions: 362     Fields:    Translation:HumansAnimalsCells
    76. Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. Mol Ther. 2013 Jan; 21(1):42-8. D'Souza AD, Parish IA, Krause DS, Kaech SM, Shadel GS. PMID: 23011031.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    77. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials. 2012 Jun; 33(19):4957-64. Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM. PMID: 22484047.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    78. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1210-5. Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS. PMID: 22167808.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    79. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity. 2011 Nov 23; 35(5):792-805. Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. PMID: 22118527.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    80. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity. 2011 Oct 28; 35(4):633-46. Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. PMID: 22018471.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    81. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. J Immunol. 2011 Oct 15; 187(8):4068-76. Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW, Kaech SM. PMID: 21930973.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    82. Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood. 2011 Nov 24; 118(22):5965-76. Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD. PMID: 21917752.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    83. Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. Am J Pathol. 2011 Jun; 178(6):2740-51. D'Souza AD, Parish IA, McKay SE, Kaech SM, Shadel GS. PMID: 21641396.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    84. IL-7 knocks the socs off chronic viral infection. Cell. 2011 Feb 18; 144(4):467-8. Parish IA, Kaech SM. PMID: 21335230.
      View in: PubMed   Mentions: 1     Fields:    
    85. Expression of kinesin superfamily genes in cultured hippocampal neurons. Cytoskeleton (Hoboken). 2010 Dec; 67(12):784-95. Silverman MA, Kaech S, Ramser EM, Lu X, Lasarev MR, Nagalla S, Banker G. PMID: 20862690.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    86. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J Immunol. 2010 Nov 01; 185(9):5315-25. Jung YW, Rutishauser RL, Joshi NS, Haberman AM, Kaech SM. PMID: 20921525.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    87. Like parent, like child: inheritance of effector CD8+ T cell traits. Immunity. 2010 Sep 24; 33(3):296-8. Jung YW, Kaech SM. PMID: 20870171.
      View in: PubMed   Mentions:    Fields:    
    88. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16601-6. Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM. PMID: 20823247.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    89. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. J Immunol. 2010 Sep 01; 185(5):2989-97. Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. PMID: 20660705.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    90. Generation of effector CD8+ T cells and their conversion to memory T cells. Immunol Rev. 2010 Jul; 236:151-66. Cui W, Kaech SM. PMID: 20636815.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    91. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 2010 Jul 01; 185(1):313-26. Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. PMID: 20519643.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    92. Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation. Immunol Rev. 2010 May; 235(1):219-33. Rutishauser RL, Kaech SM. PMID: 20536566.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    93. Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 2010 May 15; 184(10):5723-31. Hinson ER, Joshi NS, Chen JH, Rahner C, Jung YW, Wang X, Kaech SM, Cresswell P. PMID: 20410488.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    94. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity. 2009 Aug 21; 31(2):296-308. Rutishauser RL, Martins GA, Kalachikov S, Chandele A, Parish IA, Meffre E, Jacob J, Calame K, Kaech SM. PMID: 19664941.
      View in: PubMed   Mentions: 231     Fields:    Translation:AnimalsCells
    95. Diversity in CD8(+) T cell differentiation. Curr Opin Immunol. 2009 Jun; 21(3):291-7. Parish IA, Kaech SM. PMID: 19497720.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    96. Requirement of B cells for generating CD4+ T cell memory. J Immunol. 2009 Feb 15; 182(4):1868-76. Whitmire JK, Asano MS, Kaech SM, Sarkar S, Hannum LG, Shlomchik MJ, Ahmed R. PMID: 19201839.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    97. Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. Vaccine. 2009 Mar 26; 27(15):2177-87. Cui W, Joshi NS, Jiang A, Kaech SM. PMID: 19201385.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    98. Intrinsic and extrinsic control of effector T cell survival and memory T cell development. Immunol Res. 2009; 45(1):46-61. Hand TW, Kaech SM. PMID: 18629449.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    99. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol. 2008 Sep 15; 181(6):3804-10. Rahman AH, Cui W, Larosa DF, Taylor DK, Zhang J, Goldstein DR, Wherry EJ, Kaech SM, Turka LA. PMID: 18768833.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    100. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol. 2008 Aug 01; 181(3):1859-68. Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, Golub TR. PMID: 18641323.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    101. Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. J Immunol. 2008 Apr 15; 180(8):5309-19. Chandele A, Joshi NS, Zhu J, Paul WE, Leonard WJ, Kaech SM. PMID: 18390712.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    102. Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation. J Immunol. 2008 Feb 01; 180(3):1309-15. Joshi NS, Kaech SM. PMID: 18209024.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    103. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007 Oct; 27(4):670-84. Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, Ahmed R. PMID: 17950003.
      View in: PubMed   Mentions: 648     Fields:    Translation:AnimalsCells
    104. Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity. 2007 Sep; 27(3):393-405. Kaech SM, Wherry EJ. PMID: 17892848.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansAnimalsCells
    105. Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation. Mitochondrion. 2007 Dec; 7(6):374-85. D'Souza AD, Parikh N, Kaech SM, Shadel GS. PMID: 17890163.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    106. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007 Aug; 27(2):281-95. Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, Gapin L, Kaech SM. PMID: 17723218.
      View in: PubMed   Mentions: 677     Fields:    Translation:AnimalsCells
    107. Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11730-5. Hand TW, Morre M, Kaech SM. PMID: 17609371.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    108. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell. 2006 Dec; 5(6):473-86. Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, Haynes L, Kaech S, Goldstein DR. PMID: 17129212.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    109. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005 Dec; 6(12):1236-44. Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, Goldrath AW, Ahmed R, Reiner SL. PMID: 16273099.
      View in: PubMed   Mentions: 454     Fields:    Translation:HumansAnimalsCells
    110. Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. J Immunol. 2005 Nov 01; 175(9):5619-23. Chandele A, Kaech SM. PMID: 16237050.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    111. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol. 2005 Nov 01; 175(9):5783-9. Gao Y, Tao J, Li MO, Zhang D, Chi H, Henegariu O, Kaech SM, Davis RJ, Flavell RA, Yin Z. PMID: 16237070.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    112. Differentiation of CD8 T cells in response to acute and chronic viral infections: implications for HIV vaccine development. Curr Drug Targets Infect Disord. 2005 Jun; 5(2):121-9. Miller JD, Masopust D, Wherry EJ, Kaech S, Silvestri G, Ahmed R. PMID: 15975018.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    113. BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7418-25. Manders PM, Hunter PJ, Telaranta AI, Carr JM, Marshall JL, Carrasco M, Murakami Y, Palmowski MJ, Cerundolo V, Kaech SM, Ahmed R, Fearon DT. PMID: 15833813.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    114. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. J Immunol. 2005 Mar 01; 174(5):2900-9. Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, Radziewicz H, Piedimonte G, Magnani M, Montroni M, Kaech SM, Weintrob A, Altman JD, Sodora DL, Feinberg MB, Silvestri G. PMID: 15728501.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    115. The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosis. J Immunol. 2004 Nov 01; 173(9):5425-33. Sabbagh L, Kaech SM, Bourbonnière M, Woo M, Cohen LY, Haddad EK, Labrecque N, Ahmed R, Sékaly RP. PMID: 15494489.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    116. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A. 2004 Nov 09; 101(45):16004-9. Wherry EJ, Barber DL, Kaech SM, Blattman JN, Ahmed R. PMID: 15505208.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    117. Enhanced expression of cell cycle regulatory genes in virus-specific memory CD8+ T cells. J Virol. 2004 Oct; 78(20):10953-9. Latner DR, Kaech SM, Ahmed R. PMID: 15452215.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    118. The role of programming in memory T-cell development. Curr Opin Immunol. 2004 Apr; 16(2):217-25. Masopust D, Kaech SM, Wherry EJ, Ahmed R. PMID: 15023416.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    119. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol. 2003 Dec; 4(12):1191-8. Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R. PMID: 14625547.
      View in: PubMed   Mentions: 671     Fields:    Translation:AnimalsCells
    120. The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. Immunology. 2003 Sep; 110(1):10-7. Wan J, Martinvalet D, Ji X, Lois C, Kaech SM, Von Andrian UH, Lieberman J, Ahmed R, Manjunath N. PMID: 12941136.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    121. TCR signal transduction in antigen-specific memory CD8 T cells. J Immunol. 2003 Jun 01; 170(11):5455-63. Kersh EN, Kaech SM, Onami TM, Moran M, Wherry EJ, Miceli MC, Ahmed R. PMID: 12759421.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    122. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest. 2003 Jun; 111(12):1887-95. Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, Kaech SM, Wherry EJ, Onami T, Lanier JG, Kokko KE, Pearson TC, Ahmed R, Larsen CP. PMID: 12813024.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansAnimalsCells
    123. Models of CD8+ responses: 1. What is the antigen-independent proliferation program. J Theor Biol. 2003 Apr 21; 221(4):585-98. Antia R, Bergstrom CT, Pilyugin SS, Kaech SM, Ahmed R. PMID: 12713942.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    124. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med. 2003 May; 9(5):540-7. Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R. PMID: 12692546.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    125. Immunology. CD8 T cells remember with a little help. Science. 2003 Apr 11; 300(5617):263-5. Kaech SM, Ahmed R. PMID: 12690179.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    126. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol. 2003 Mar; 4(3):225-34. Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, von Andrian UH, Ahmed R. PMID: 12563257.
      View in: PubMed   Mentions: 613     Fields:    Translation:AnimalsCells
    127. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol. 2003 Feb 01; 170(3):1443-51. Shen H, Whitmire JK, Fan X, Shedlock DJ, Kaech SM, Ahmed R. PMID: 12538706.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    128. Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells. J Immunol. 2003 Jan 01; 170(1):147-52. Hathcock KS, Kaech SM, Ahmed R, Hodes RJ. PMID: 12496394.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    129. Molecular and functional profiling of memory CD8 T cell differentiation. Cell. 2002 Dec 13; 111(6):837-51. Kaech SM, Hemby S, Kersh E, Ahmed R. PMID: 12526810.
      View in: PubMed   Mentions: 322     Fields:    Translation:AnimalsCells
    130. Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol. 2002 Apr; 2(4):251-62. Kaech SM, Wherry EJ, Ahmed R. PMID: 12001996.
      View in: PubMed   Mentions: 453     Fields:    Translation:HumansAnimalsCells
    131. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J Exp Med. 2002 Mar 04; 195(5):657-64. Blattman JN, Antia R, Sourdive DJ, Wang X, Kaech SM, Murali-Krishna K, Altman JD, Ahmed R. PMID: 11877489.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    132. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science. 2001 Oct 12; 294(5541):374-80. Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M, Hemmings BA. PMID: 11598301.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    133. Cytoskeletal microdifferentiation: a mechanism for organizing morphological plasticity in dendrites. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7086-92. Kaech S, Parmar H, Roelandse M, Bornmann C, Matus A. PMID: 11416192.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    134. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol. 2001 May; 2(5):415-22. Kaech SM, Ahmed R. PMID: 11323695.
      View in: PubMed   Mentions: 371     Fields:    Translation:AnimalsCells
    135. Glutamate receptors regulate actin-based plasticity in dendritic spines. Nat Neurosci. 2000 Sep; 3(9):887-94. Fischer M, Kaech S, Wagner U, Brinkhaus H, Matus A. PMID: 10966619.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    136. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem. 1998 Nov 27; 273(48):31633-6. Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B. PMID: 9822620.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    137. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell. 1998 Sep 18; 94(6):761-71. Kaech SM, Whitfield CW, Kim SK. PMID: 9753323.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    138. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell. 1996 Apr 19; 85(2):195-204. Simske JS, Kaech SM, Harp SA, Kim SK. PMID: 8612272.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    139. Improved lipid-mediated gene transfer into primary cultures of hippocampal neurons. Brain Res Mol Brain Res. 1996 Jan; 35(1-2):344-8. Kaech S, Kim JB, Cariola M, Ralston E. PMID: 8717375.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    140. Molecular characterization of a neuronal-specific protein that stimulates the activity of Cdk5. J Neurochem. 1995 May; 64(5):1988-95. Shetty KT, Kaech S, Link WT, Jaffe H, Flores CM, Wray S, Pant HC, Beushausen S. PMID: 7536802.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    141. Myristylation and amino-terminal phosphorylation are required for activation of pp60c-src during mitosis. Oncogene. 1993 Mar; 8(3):575-81. Kaech S, Schnierle B, Wyss A, Ballmer-Hofer K. PMID: 7679790.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    142. Association of p60c-src with polyoma virus middle-T antigen abrogating mitosis-specific activation. Nature. 1991 Apr 04; 350(6317):431-3. Kaech S, Covic L, Wyss A, Ballmer-Hofer K. PMID: 1707141.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    143. Myristylation of pp60c-src is not required for complex formation with polyomavirus middle-T antigen. J Virol. 1990 Oct; 64(10):5163-6. Wyss A, Kaech S, Ballmer-Hofer K. PMID: 2168992.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    144. Stimulation of pp60c-src kinase activity in FDC-P1 cells by polyoma middle-T antigen and hematopoietic growth factors. Oncogene. 1989 Dec; 4(12):1433-9. Muser J, Kaech S, Moroni C, Ballmer-Hofer K. PMID: 2480561.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells