Susan Kaech

Title(s)Adjunct Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic heterogeneity of tissue resident memory T cells in the liver
    NIH R21AI151562Mar 6, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Metabolic regulation of epigenetic states in CD8 T cell exhaustion
    NIH R21AI151986Mar 5, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunity
    NIH R01CA240909Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Understanding and Overcoming Resistance to Cancer Immunotherapy Due to Defective Antigen Presentation
    NIH R01CA230275Feb 6, 2019 - Jan 31, 2024
    Role: Co-Principal Investigator
    (PQ5) Mitochondrial Heterogeneity in Melanoma Tumor and Immune Responses
    NIH R01CA216101Sep 1, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    (PQ1) Lipid Metabolism, Inflammation, and T cell Dysfunction in HIV-associated Cancer
    NIH R01CA206483Jun 1, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Discovery of NR4A1/2 ligands controlling tissue-resident memory T (Trm) cells
    NIH R21AI131015Jan 1, 2017 - Dec 31, 2019
    Role: Co-Principal Investigator
    Cellular Mechanisms of Viral Control
    NIH R01AI123864Mar 15, 2016 - Feb 28, 2021
    Role: Co-Principal Investigator
    Targeting the Immune System in Mouse Models of Lung Adenocarcinoma
    NIH R01CA195720Apr 16, 2015 - Mar 31, 2018
    Role: Co-Principal Investigator
    The role of STAT3 in effector and memory CD8 T cell longevity and metabolism
    NIH R21AI097767Feb 1, 2012 - Jan 31, 2015
    Role: Principal Investigator
    iCyt Reflection Cell Sorter
    NIH S10RR029602Dec 10, 2009 - Dec 9, 2011
    Role: Principal Investigator
    Transcriptional control of IL-7 receptor (IL-7R) in T cells
    NIH R03TW008208Aug 10, 2009 - May 31, 2013
    Role: Principal Investigator
    Control of Effector and Memory T Cell Development by Inflammatory Signals
    NIH R01AI074699Jun 25, 2009 - May 31, 2015
    Role: Principal Investigator
    Determining how adjuvants alter effector and memory T cells during vaccination
    NIH R21AI081150May 22, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Control of Terminal Differentiation of Effector and Memory T Cells by Blimp-1
    NIH R21AI077075Aug 15, 2007 - Jul 31, 2009
    Role: Principal Investigator
    Regulation of memory CD8 T cell development
    NIH R37AI066232May 1, 2005 - Jan 31, 2023
    Role: Principal Investigator
    Regulation of memory CD8 T cell development
    NIH R01AI066232May 1, 2005 - Jan 31, 2013
    Role: Principal Investigator
    Priming of Memory and Effector CD4 T Cells
    NIH R01CA038350Mar 1, 1984 - Dec 31, 2009
    Role: Principal Investigator
    Salk Institute Cancer Training Grant
    NIH T32CA009370Sep 1, 1980 - Jun 30, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A phase I study of APX005M and cabiralizumab with/without nivolumab in patients with melanoma, kidney cancer or non-small cell lung cancer resistant to anti-PD-(L)1. Clin Cancer Res. 2021 Jun 17. Weiss SA, Djureinovic D, Jessel S, Krykbaeva I, Zhang L, Jilaveanu L, Ralabate A, Johnson B, Shanwetter Levit N, Anderson G, Zelterman D, Wei W, Mahajan A, Trifan O, Bosenberg M, Kaech SM, Perry CJ, Damsky W, Gettinger S, Sznol M, Hurwitz M, Kluger HM. PMID: 34140403.
      View in: PubMed   Mentions:    Fields:    
    2. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 2021 May 28. Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho PC, Witztum JL, Emu B, Cui G, Kaech SM. PMID: 34102100.
      View in: PubMed   Mentions: 1     Fields:    
    3. Motility Matters: How CD8+ T-Cell Trafficking Influences Effector and Memory Cell Differentiation. Cold Spring Harb Perspect Biol. 2021 May 17. Farsakoglu Y, McDonald B, Kaech SM. PMID: 34001529.
      View in: PubMed   Mentions:    Fields:    
    4. How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications. Trends Immunol. 2021 May; 42(5):401-417. Van Acker HH, Ma S, Scolaro T, Kaech SM, Mazzone M. PMID: 33867272.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates. J Exp Med. 2021 Apr 05; 218(4). Chung HK, McDonald B, Kaech SM. PMID: 33755719.
      View in: PubMed   Mentions:    Fields:    
    6. Parallels between the anti-Viral State and the Irradiated State. J Natl Cancer Inst. 2020 Nov 30. McGee HM, Marciscano AE, Campbell AM, Monjazeb AM, Kaech SM, Teijaro JR. PMID: 33252657.
      View in: PubMed   Mentions:    Fields:    
    7. Immigration in science. J Exp Med. 2020 11 02; 217(11). Casanova JL, Holtzman DM, Kaech SM, Lanier LL, Nathan CF, Rudensky AY, Tuveson D, Wolchok JD. PMID: 33057576.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. J Exp Med. 2020 08 03; 217(8). Low JS, Farsakoglu Y, Amezcua Vesely MC, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. PMID: 32525985.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    9. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. Gastroenterology. 2020 11; 159(5):1866-1881.e8. DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM. PMID: 32717220.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    10. Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations. Cancer Res. 2020 05 15; 80(10):2017-2030. Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech SM, Unni AM, Homer R, Lockwood WW, Michor F, Goldberg SB, Lemmon MA, Smith PD, Cross DAE, Politi K. PMID: 32193290.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    11. JEM women in STEM: Unique journeys with a common purpose. J Exp Med. 2020 03 02; 217(3). O'Garra A, Belkaid Y, Sharpe A, Kaech S, Cherry S, Passegué E. PMID: 33002100.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults. J Immunol. 2020 03 15; 204(6):1661-1673. Avey S, Mohanty S, Chawla DG, Meng H, Bandaranayake T, Ueda I, Zapata HJ, Park K, Blevins TP, Tsang S, Belshe RB, Kaech SM, Shaw AC, Kleinstein SH. PMID: 32060136.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    13. Reinvigorating NIH Grant Peer Review. Immunity. 2020 01 14; 52(1):1-3. Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, Krummel M, Pepper M, Rothlin CV, Wherry EJ, Once-a-Year Pledge Supporters . PMID: 31940266.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Mitochondrial DNA Stress Signalling Protects the Nuclear Genome. Nat Metab. 2019 12; 1(12):1209-1218. Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. PMID: 32395698.
      View in: PubMed   Mentions:
    15. T Cell Metabolism in a State of Flux. Immunity. 2019 11 19; 51(5):783-785. Varanasi SK, Ma S, Kaech SM. PMID: 31747577.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth. Oncogene. 2020 01; 39(3):560-573. Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR, Han W, Sherwin RS, Nie Y, Yang X. PMID: 31501520.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell. 2019 09 19; 179(1):236-250.e18. Harel M, Ortenberg R, Varanasi SK, Mangalhara KC, Mardamshina M, Markovits E, Baruch EN, Tripple V, Arama-Chayoth M, Greenberg E, Shenoy A, Ayasun R, Knafo N, Xu S, Anafi L, Yanovich-Arad G, Barnabas GD, Ashkenazi S, Besser MJ, Schachter J, Bosenberg M, Shadel GS, Barshack I, Kaech SM, Markel G, Geiger T. PMID: 31495571.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    18. Tick-TOX, it's time for T cell exhaustion. Nat Immunol. 2019 09; 20(9):1092-1094. Mann TH, Kaech SM. PMID: 31427776.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    19. The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment. Oncotarget. 2019 Jul 16; 10(44):4532-4545. Gaffney SG, Perry EB, Chen PM, Greenstein A, Kaech SM, Townsend JP. PMID: 31360302.
      View in: PubMed   Mentions: 2     Fields:    
    20. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. J Immunother Cancer. 2019 07 10; 7(1):172. Ayeni D, Miller B, Kuhlmann A, Ho PC, Robles-Oteiza C, Gaefele M, Levy S, de Miguel FJ, Perry C, Guan T, Krystal G, Lockwood W, Zelterman D, Homer R, Liu Z, Kaech S, Politi K. PMID: 31291990.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPa expression. Nat Commun. 2019 02 15; 10(1):794. Myers LM, Tal MC, Torrez Dulgeroff LB, Carmody AB, Messer RJ, Gulati G, Yiu YY, Staron MM, Angel CL, Sinha R, Markovic M, Pham EA, Fram B, Ahmed A, Newman AM, Glenn JS, Davis MM, Kaech SM, Weissman IL, Hasenkrug KJ. PMID: 30770827.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    22. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep. 2018 10 30; 25(5):1204-1213.e4. Fan MY, Low JS, Tanimine N, Finn KK, Priyadharshini B, Germana SK, Kaech SM, Turka LA. PMID: 30380412.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    23. T-bet in Tfh cells: Now you see me, now you don't. J Exp Med. 2018 11 05; 215(11):2697-2698. Kaech SM. PMID: 30337467.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression. J Immunol. 2018 08 01; 201(3):908-915. Arojo OA, Ouyang X, Liu D, Meng T, Kaech SM, Pereira JP, Su B. PMID: 29934471.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    25. Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response. Oncotarget. 2018 May 25; 9(40):25808-25825. Pereira FV, Melo ACL, Low JS, de Castro ÍA, Braga TT, Almeida DC, Batista de Lima AGU, Hiyane MI, Correa-Costa M, Andrade-Oliveira V, Origassa CST, Pereira RM, Kaech SM, Rodrigues EG, Câmara NOS. PMID: 29899823.
      View in: PubMed   Mentions: 15     Fields:    
    26. KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 2018 04 17; 48(4):716-729.e8. Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA. PMID: 29625895.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    27. Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non-Small Cell Lung Cancer. J Thorac Oncol. 2018 06; 13(6):831-839. Gettinger SN, Wurtz A, Goldberg SB, Rimm D, Schalper K, Kaech S, Kavathas P, Chiang A, Lilenbaum R, Zelterman D, Politi K, Herbst RS. PMID: 29578107.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    28. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates. J Exp Med. 2018 04 02; 215(4):1153-1168. Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM. PMID: 29449309.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    29. Correction: STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med. 2018 03 05; 215(3):999. Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. PMID: 29440270.
      View in: PubMed   Mentions: 1     Fields:    
    30. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med. 2018 03 05; 215(3):877-893. Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, Du VY, Wang JX, Damsky W, Kuhlmann AL, Sher JW, Bosenberg M, Miller-Jensen K, Kaech SM. PMID: 29436395.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    31. Trials and Tribble-ations of tissue TRM cells. Nat Immunol. 2018 02; 19(2):102-103. Low JS, Kaech SM. PMID: 29348504.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    32. STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med. 2018 01 02; 215(1):337-355. Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. PMID: 29212666.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    33. Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Sci Immunol. 2017 10 20; 2(16). Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J. PMID: 29054998.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    34. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Cancer Discov. 2017 12; 7(12):1420-1435. Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K. PMID: 29025772.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansCells
    35. IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways. Sci Rep. 2017 09 11; 7(1):11155. Yeon SM, Halim L, Chandele A, Perry CJ, Kim SH, Kim SU, Byun Y, Yuk SH, Kaech SM, Jung YW. PMID: 28894184.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. PLoS Pathog. 2017 Aug; 13(8):e1006544. Shin HM, Kapoor VN, Kim G, Li P, Kim HR, Suresh M, Kaech SM, Wherry EJ, Selin LK, Leonard WJ, Welsh RM, Berg LJ. PMID: 28827827.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    37. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. J Immunol. 2017 08 15; 199(4):1250-1260. Roberts NA, Adams BD, McCarthy NI, Tooze RM, Parnell SM, Anderson G, Kaech SM, Horsley V. PMID: 28701508.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    38. UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. Pigment Cell Melanoma Res. 2017 07; 30(4):428-435. Wang J, Perry CJ, Meeth K, Thakral D, Damsky W, Micevic G, Kaech S, Blenman K, Bosenberg M. PMID: 28379630.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    39. Metabolic Instruction of Immunity. Cell. 2017 05 04; 169(4):570-586. Buck MD, Sowell RT, Kaech SM, Pearce EL. PMID: 28475890.
      View in: PubMed   Mentions: 269     Fields:    Translation:HumansAnimalsCells
    40. Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries. Curr Opin Immunol. 2017 Jun; 46:38-44. Ho PC, Kaech SM. PMID: 28458087.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    41. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency. Immunity. 2017 04 18; 46(4):596-608. Gray SM, Amezquita RA, Guan T, Kleinstein SH, Kaech SM. PMID: 28410989.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    42. TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. Cancer. 2017 05 15; 123(10):1778-1790. Hajek M, Sewell A, Kaech S, Burtness B, Yarbrough WG, Issaeva N. PMID: 28295222.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    43. Immunology: The chronicles of T-cell exhaustion. Nature. 2017 03 09; 543(7644):190-191. Amezquita RA, Kaech SM. PMID: 28225757.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    44. IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci Immunol. 2016 Oct; 1(5). Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ. PMID: 28713870.
      View in: PubMed   Mentions: 10     Fields:    
    45. NK Cell Responses Redefine Immunological Memory. J Immunol. 2016 10 15; 197(8):2963-2970. Adams NM, O'Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC. PMID: 27824591.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    46. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. J Clin Invest. 2016 10 03; 126(10):3905-3916. Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV. PMID: 27617863.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    47. Probing the Diversity of T Cell Dysfunction in Cancer. Cell. 2016 Sep 08; 166(6):1362-1364. Sowell RT, Kaech SM. PMID: 27610560.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    48. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016 08 01; 6:30636. Kritikou JS, Dahlberg CI, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, Wermeling F, Andersson J, Orange JS, Brauner H, Westerberg LS. PMID: 27477778.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    49. CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8278-83. Jung YW, Kim HG, Perry CJ, Kaech SM. PMID: 27385825.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    50. Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE. J Biol Chem. 2016 May 20; 291(21):11230-40. Garyu JW, Uduman M, Stewart A, Rui J, Deng S, Shenson J, Staron MM, Kaech SM, Kleinstein SH, Herold KC. PMID: 26994137.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    51. A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet. Nat Immunol. 2016 Apr; 17(4):422-32. Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A. PMID: 26950239.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    52. The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nat Rev Immunol. 2016 Feb; 16(2):102-11. Laidlaw BJ, Craft JE, Kaech SM. PMID: 26781939.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCellsPHPublic Health
    53. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. J Exp Med. 2015 Nov 16; 212(12):2041-56. Dominguez CX, Amezquita RA, Guan T, Marshall HD, Joshi NS, Kleinstein SH, Kaech SM. PMID: 26503446.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    54. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20; 43(4):690-702. Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J. PMID: 26410627.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    55. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Sep 10; 162(6):1217-28. Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. PMID: 26321681.
      View in: PubMed   Mentions: 400     Fields:    Translation:AnimalsCells
    56. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat Immunol. 2015 Aug; 16(8):871-9. Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. PMID: 26147684.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    57. IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity. Cell. 2015 May 07; 161(4):750-61. Cui G, Staron MM, Gray SM, Ho PC, Amezquita RA, Wu J, Kaech SM. PMID: 25957683.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
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    59. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015 Feb 12; 160(4):745-758. Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. PMID: 25662011.
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    62. The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. Elife. 2015 Jan 08; 4:e04851. Marshall HD, Ray JP, Laidlaw BJ, Zhang N, Gawande D, Staron MM, Craft J, Kaech SM. PMID: 25569154.
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    63. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging (Albany NY). 2015 Jan; 7(1):38-52. Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC. PMID: 25596819.
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    64. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis. 2015 Apr 01; 211(7):1174-84. Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC. PMID: 25367297.
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    65. A central role for Notch in effector CD8(+) T cell differentiation. Nat Immunol. 2014 Dec; 15(12):1143-51. Backer RA, Helbig C, Gentek R, Kent A, Laidlaw BJ, Dominguez CX, de Souza YS, van Trierum SE, van Beek R, Rimmelzwaan GF, ten Brinke A, Willemsen AM, van Kampen AH, Kaech SM, Blander JM, van Gisbergen K, Amsen D. PMID: 25344724.
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    66. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity. 2014 Oct 16; 41(4):633-45. Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM. PMID: 25308332.
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    68. CD4? and CD8? T cell-dependent antiviral immunity requires STIM1 and STIM2. J Clin Invest. 2014 Oct; 124(10):4549-63. Shaw PJ, Weidinger C, Vaeth M, Luethy K, Kaech SM, Feske S. PMID: 25157823.
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    69. T-cell TGF-ß signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3458-66. Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. PMID: 25082897.
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    70. Regulating the diverse outcomes of interferon's interference. Trends Immunol. 2014 Aug; 35(8):353-4. Marshall HD, Kaech SM. PMID: 25052591.
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    72. BRAF-targeted therapy alters the functions of intratumoral CD4+ T cells to inhibit melanoma progression. Oncoimmunology. 2014; 3:e29126. Ho PC, Kaech SM. PMID: 25083331.
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    74. TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. J Immunol. 2014 May 01; 192(9):4221-32. Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH, Kaech SM. PMID: 24659688.
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    75. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity. 2014 Mar 20; 40(3):367-77. Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J. PMID: 24631156.
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    76. Celebrating diversity in memory T cells. J Immunol. 2014 Feb 01; 192(3):837-9. Kaech SM. PMID: 24443505.
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    77. Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. Immunity. 2013 Nov 14; 39(5):939-48. Slütter B, Pewe LL, Kaech SM, Harty JT. PMID: 24238342.
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    78. Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection. Immunity. 2013 Oct 17; 39(4):661-75. Shin HM, Kapoor V, Guan T, Kaech SM, Welsh RM, Berg LJ. PMID: 24120360.
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    79. Generating CD8 T cell heterogeneity: attack of the clones. Immunity. 2013 Aug 22; 39(2):203-5. Marshall HD, Kaech SM. PMID: 23973217.
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    81. The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity. 2013 May 23; 38(5):984-97. Henao-Mejia J, Williams A, Goff LA, Staron M, Licona-Limón P, Kaech SM, Nakayama M, Rinn JL, Flavell RA. PMID: 23623381.
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    82. MLL Rearrangment and EVI1 Deletion in BCR/ABL1 Positive Chronic Myeloid Leukemia. J Assoc Genet Technol. 2013; 39(4):190-4. Ivanov A, Sukhanova M, Raul T, Borinets O, Hui W, Aggarwal V, Raca G. PMID: 25464856.
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    85. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials. 2012 Jun; 33(19):4957-64. Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM. PMID: 22484047.
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    87. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity. 2011 Nov 23; 35(5):792-805. Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. PMID: 22118527.
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    88. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity. 2011 Oct 28; 35(4):633-46. Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. PMID: 22018471.
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    90. Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood. 2011 Nov 24; 118(22):5965-76. Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD. PMID: 21917752.
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    92. IL-7 knocks the socs off chronic viral infection. Cell. 2011 Feb 18; 144(4):467-8. Parish IA, Kaech SM. PMID: 21335230.
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    94. Like parent, like child: inheritance of effector CD8+ T cell traits. Immunity. 2010 Sep 24; 33(3):296-8. Jung YW, Kaech SM. PMID: 20870171.
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    96. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. J Immunol. 2010 Sep 01; 185(5):2989-97. Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. PMID: 20660705.
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