Sadatsugu Sakane

Title(s)Postdoctoral Scholar, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    1. Single cell multiomics reveals drivers of metabolic dysfunction-associated steatohepatitis. medRxiv. 2025 May 11. Elison W, Chang L, Xie Y, Miciano C, Yang Q, Mummey H, Lancione R, Corban S, Sakane S, Lucero J, Mamde S, Kim HY, Kim MJ, Melton R, Tucciarone L, Lie A, Loe T, Vashist T, Dang K, Elgamal R, Li D, Vu M, Farah EN, Seng C, Djulamsah J, Yang B, Buchanan J, Miller M, Tran M, Birrueta JO, Chi NC, Wang T, D'Antonio-Chronowska A, Wang A, Kisseleva T, Brenner D, Ren B, Gaulton KJ. PMID: 40385416; PMCID: PMC12083587.
      View in: PubMed   Mentions:
    2. Author Correction: FBP1 controls liver cancer evolution from senescent MASH hepatocytes. Nature. 2025 Feb; 638(8051):E30. Gu L, Zhu Y, Nandi SP, Lee M, Watari K, Bareng B, Ohira M, Liu Y, Sakane S, Carlessi R, Sauceda C, Dhar D, Ganguly S, Hosseini M, Teneche MG, Adams PD, Gonzalez DJ, Kisseleva T, Liver Cancer Collaborative, Tirnitz-Parker JEE, Simon MC, Alexandrov LB, Karin M. PMID: 39890899.
      View in: PubMed   Mentions:    Fields:    
    3. Revisiting the relationship between thyroid function and metabolic dysfunction-associated steatotic liver disease in the era of resmetirom. J Gastroenterol. 2025 Mar; 60(3):389-391. Sakane S, Hikita H. PMID: 39847088.
      View in: PubMed   Mentions:    Fields:    
    4. FBP1 controls liver cancer evolution from senescent MASH hepatocytes. Nature. 2025 Jan; 637(8045):461-469. Gu L, Zhu Y, Nandi SP, Lee M, Watari K, Bareng B, Ohira M, Liu Y, Sakane S, Carlessi R, Sauceda C, Dhar D, Ganguly S, Hosseini M, Teneche MG, Adams PD, Gonzalez DJ, Kisseleva T, Liver Cancer Collaborative, Tirnitz-Parker JEE, Simon MC, Alexandrov LB, Karin M. PMID: 39743585.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Multi-modal analysis of human hepatic stellate cells identifies novel therapeutic targets for metabolic dysfunction-associated steatotic liver disease. J Hepatol. 2025 May; 82(5):882-897. Kim HY, Rosenthal SB, Liu X, Miciano C, Hou X, Miller M, Buchanan J, Poirion OB, Chilin-Fuentes D, Han C, Housseini M, Carvalho-Gontijo Weber R, Sakane S, Lee W, Zhao H, Diggle K, Preissl S, Glass CK, Ren B, Wang A, Brenner DA, Kisseleva T. PMID: 39522884.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Serum amyloid P (PTX2) attenuates hepatic fibrosis in mice by inhibiting the activation of fibrocytes and HSCs. Hepatol Commun. 2024 Nov 01; 8(11). Cong M, Carvalho Gontijo Weber R, Sakane S, Zhang V, Jiang C, Taura K, Kodama Y, DeMinicis S, Ganguly S, Brafman D, Chien S, Kramer M, Lupher M, Brenner DA, Xu J, Kisseleva T. PMID: 39761005; PMCID: PMC11495776.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Protocol to generate human liver spheroids to study liver fibrosis induced by metabolic stress. STAR Protoc. 2024 Jun 21; 5(2):103111. Kim HY, Lee W, Liu X, Jang H, Sakane S, Carvalho-Gontijo Weber R, Diggle K, Kerk SA, Metallo CM, Kisseleva T, Brenner DA. PMID: 38833372; PMCID: PMC11179098.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Serum growth differentiation factor 15 is a novel biomarker with high predictive capability for liver cancer occurrence in patients with MASLD regardless of liver fibrosis. Aliment Pharmacol Ther. 2024 08; 60(3):327-339. Kumazaki S, Hikita H, Tahata Y, Sung JH, Fukumoto K, Myojin Y, Sakane S, Murai K, Sasaki Y, Shirai K, Saito Y, Kodama T, Kakita N, Takahashi H, Toyoda H, Suda G, Morii E, Kojima T, Ebihara T, Shimizu K, Sasaki Y, Tatsumi T, Takehara T. PMID: 38828944.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD. Hepatol Commun. 2024 06 01; 8(6). Sakane S, Hikita H, Shirai K, Sakamoto T, Narumi R, Adachi J, Kakita N, Yamada Y, Toyoda H, Takahashi H, Suda G, Kai M, Tahata Y, Sakamori R, Kumazaki S, Fukumoto K, Myojin Y, Murai K, Kodama T, Tatsumi T, Tomonaga T, Sakamoto N, Morii E, Takehara T. PMID: 38829196; PMCID: PMC11150025.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metab. 2024 May 07; 36(5):1030-1043.e7. Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. PMID: 38670107; PMCID: PMC11113091.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression. Biomolecules. 2024 Mar 27; 14(4). Osna NA, Tikhanovich I, Ortega-Ribera M, Mueller S, Zheng C, Mueller J, Li S, Sakane S, Weber RCG, Kim HY, Lee W, Ganguly S, Kimura Y, Liu X, Dhar D, Diggle K, Brenner DA, Kisseleva T, Attal N, McKillop IH, Chokshi S, Mahato R, Rasineni K, Szabo G, Kharbanda KK. PMID: 38672422; PMCID: PMC11048648.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. The Origin and Fate of Liver Myofibroblasts. Cell Mol Gastroenterol Hepatol. 2024; 17(1):93-106. Kim HY, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T. PMID: 37743012; PMCID: PMC10665929.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    13. Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers. STAR Protoc. 2023 Sep 15; 4(3):102391. Liu X, Lam K, Zhao H, Sakane S, Kim HY, Eguileor A, Diggle K, Wu S, Gontijo Weber RC, Soroosh P, Hosseini M, Mekeel K, Brenner DA, Kisseleva T. PMID: 37405925; PMCID: PMC10345194.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Fucosylated haptoglobin is a novel predictive marker of hepatocellular carcinoma after hepatitis C virus elimination in patients with advanced liver fibrosis. PLoS One. 2022; 17(12):e0279416. Shirai K, Hikita H, Sakamori R, Doi A, Tahata Y, Sakane S, Kamada Y, Murai K, Nishio A, Yamada R, Kodama T, Nozaki Y, Kakita N, Ishida H, Nakanishi F, Morishita N, Imanaka K, Sakakibara M, Tatsumi T, Miyoshi E, Takehara T. PMID: 36542633; PMCID: PMC9770342.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Pentraxin 3 is an adipose tissue-related serum marker for pancreatic cancer cachexia predicting subsequent muscle mass and visceral fat loss. Cancer Sci. 2022 Dec; 113(12):4311-4326. Sato K, Hikita H, Shigekawa M, Kato S, Sasaki Y, Shinkai K, Fukuoka M, Kudo S, Sato Y, Fukumoto K, Shirai K, Myojin Y, Sakane S, Murai K, Yoshioka T, Nishio A, Kodama T, Sakamori R, Tatsumi T, Takehara T. PMID: 36074525; PMCID: PMC9746057.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    16. STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression. Cell Mol Gastroenterol Hepatol. 2023; 15(1):99-119. Makino Y, Hikita H, Kato S, Sugiyama M, Shigekawa M, Sakamoto T, Sasaki Y, Murai K, Sakane S, Kodama T, Sakamori R, Kobayashi S, Eguchi H, Takemura N, Kokudo N, Yokoi H, Mukoyama M, Tatsumi T, Takehara T. PMID: 36210625; PMCID: PMC9672888.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis. Cancer Res. 2022 08 16; 82(16):2860-2873. Makino Y, Hikita H, Fukumoto K, Sung JH, Sakano Y, Murai K, Sakane S, Kodama T, Sakamori R, Kondo J, Kobayashi S, Tatsumi T, Takehara T. PMID: 35696550; PMCID: PMC9379366.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    18. Serum amyloid P component and pro-platelet basic protein in extracellular vesicles or serum are novel markers of liver fibrosis in chronic hepatitis C patients. PLoS One. 2022; 17(7):e0271020. Shirai K, Hikita H, Sakane S, Narumi R, Adachi J, Doi A, Tanaka S, Tahata Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Mita E, Tomonaga T, Takehara T. PMID: 35797333; PMCID: PMC9262231.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. Letter: serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination-authors' reply. Aliment Pharmacol Ther. 2022 04; 55(8):1061-1062. Myojin Y, Hikita H, Tahata Y, Doi A, Kato S, Sasaki Y, Shirai K, Sakane S, Yamada R, Kodama T, Hagiwara H, Imai Y, Hiramatsu N, Tamura S, Yamamoto K, Ohkawa K, Hijioka T, Fukui H, Doi Y, Yamada Y, Yakushijin T, Mita E, Sakamori R, Tatsumi T, Takehara T. PMID: 35362133.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination. Aliment Pharmacol Ther. 2022 02; 55(4):422-433. Myojin Y, Hikita H, Tahata Y, Doi A, Kato S, Sasaki Y, Shirai K, Sakane S, Yamada R, Kodama T, Hagiwara H, Imai Y, Hiramatsu N, Tamura S, Yamamoto K, Ohkawa K, Hijioka T, Fukui H, Doi Y, Yamada Y, Yakushijin T, Mita E, Sakamori R, Tatsumi T, Takehara T. PMID: 34812502.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Hepatocellular Carcinoma in a Patient with Tetralogy of Fallot: A Case Report and Literature Review. Intern Med. 2022 May 01; 61(9):1361-1365. Hyun Sung J, Sakamori R, Yamada R, Yoshioka T, Sakane S, Tahata Y, Shigekawa M, Kodama T, Hikita H, Tatsumi T, Takehara T. PMID: 34670885; PMCID: PMC9152848.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Activation of p53 After Irradiation Impairs the Regenerative Capacity of the Mouse Liver. Hepatol Commun. 2022 02; 6(2):411-422. Urabe M, Hikita H, Saito Y, Kudo S, Fukumoto K, Mizutani N, Myojin Y, Doi A, Sato K, Sakane S, Makino Y, Kodama T, Sakamori R, Tatsumi T, Takehara T. PMID: 34585534; PMCID: PMC8793995.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis. Hepatology. 2021 11; 74(5):2452-2466. Kozumi K, Kodama T, Murai H, Sakane S, Govaere O, Cockell S, Motooka D, Kakita N, Yamada Y, Kondo Y, Tahata Y, Yamada R, Hikita H, Sakamori R, Kamada Y, Daly AK, Anstee QM, Tatsumi T, Morii E, Takehara T. PMID: 34105780; PMCID: PMC8596693.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    24. White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice. Cell Mol Gastroenterol Hepatol. 2021; 12(5):1683-1699. Sakane S, Hikita H, Shirai K, Myojin Y, Sasaki Y, Kudo S, Fukumoto K, Mizutani N, Tahata Y, Makino Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T. PMID: 34303881; PMCID: PMC8551788.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    25. Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis. Am J Physiol Gastrointest Liver Physiol. 2021 06 01; 320(6):G958-G968. Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T. PMID: 33787344.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration. Sci Rep. 2021 02 09; 11(1):3363. Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, Myojin Y, Doi A, Murai K, Sakane S, Saito Y, Kodama T, Sakamori R, Tatsumi T, Takehara T. PMID: 33564095; PMCID: PMC7873060.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    27. Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production. Gastroenterology. 2021 04; 160(5):1741-1754.e16. Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T. PMID: 33346004.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    28. Hepatitis C virus enhances Rubicon expression, leading to autophagy inhibition and intracellular innate immune activation. Sci Rep. 2020 09 17; 10(1):15290. Shiode Y, Hikita H, Tanaka S, Shirai K, Doi A, Sakane S, Kai Y, Nakabori T, Yamada R, Kodama T, Narumi R, Sakamori R, Eguchi H, Tomonaga T, Tatsumi T, Takehara T. PMID: 32943718; PMCID: PMC7498609.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    29. Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels. PLoS One. 2020; 15(7):e0235573. Sato K, Hikita H, Myojin Y, Fukumoto K, Murai K, Sakane S, Tamura T, Yamai T, Nozaki Y, Yoshioka T, Kodama T, Shigekawa M, Sakamori R, Tatsumi T, Takehara T. PMID: 32609742; PMCID: PMC7329089.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice. Hepatology. 2016 12; 64(6):1994-2014. Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T. PMID: 27637015.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    31. Administration of low-dose epoetin-alpha facilitates adherence to ribavirin in triple therapy with pegylated interferon-alpha-2b and telaprevir. Hepatol Res. 2014 Oct; 44(10):E84-91. Ishida H, Sakane S, Toyama T, Fukutomi K, Kimura K, Sugimoto A, Hibino K, Tamura T, Iwasaki T, Iwasaki R, Hasegawa H, Sakakibara Y, Yamada T, Nakazuru S, Mita E. PMID: 23957840.
      View in: PubMed   Mentions: 1  
    32. Suprathreshold stochastic resonance in visual signal detection. Behav Brain Res. 2008 Nov 03; 193(1):152-5. Sasaki H, Sakane S, Ishida T, Todorokihara M, Kitamura T, Aoki R. PMID: 18565603.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    33. Subthreshold noise facilitates the detection and discrimination of visual signals. Neurosci Lett. 2008 May 09; 436(2):255-8. Sasaki H, Sakane S, Ishida T, Todorokihara M, Kitamura T, Aoki R. PMID: 18400398.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsPHPublic Health
    34. A colorimetric assay for studying effector secretion through the bacterial type III secretion system. FEMS Microbiol Lett. 2008 Jan; 278(1):36-42. Miyake M, Sakane S, Kobayashi C, Hanajima-Ozawa M, Fukui A, Kamitani S, Horiguchi Y. PMID: 17995954.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
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