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Single cell multiomics reveals drivers of metabolic dysfunction-associated steatohepatitis. medRxiv. 2025 May 11.
Elison W, Chang L, Xie Y, Miciano C, Yang Q, Mummey H, Lancione R, Corban S, Sakane S, Lucero J, Mamde S, Kim HY, Kim MJ, Melton R, Tucciarone L, Lie A, Loe T, Vashist T, Dang K, Elgamal R, Li D, Vu M, Farah EN, Seng C, Djulamsah J, Yang B, Buchanan J, Miller M, Tran M, Birrueta JO, Chi NC, Wang T, D'Antonio-Chronowska A, Wang A, Kisseleva T, Brenner D, Ren B, Gaulton KJ. PMID: 40385416; PMCID: PMC12083587.
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Author Correction: FBP1 controls liver cancer evolution from senescent MASH hepatocytes. Nature. 2025 Feb; 638(8051):E30.
Gu L, Zhu Y, Nandi SP, Lee M, Watari K, Bareng B, Ohira M, Liu Y, Sakane S, Carlessi R, Sauceda C, Dhar D, Ganguly S, Hosseini M, Teneche MG, Adams PD, Gonzalez DJ, Kisseleva T, Liver Cancer Collaborative, Tirnitz-Parker JEE, Simon MC, Alexandrov LB, Karin M. PMID: 39890899.
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Revisiting the relationship between thyroid function and metabolic dysfunction-associated steatotic liver disease in the era of resmetirom. J Gastroenterol. 2025 Mar; 60(3):389-391.
Sakane S, Hikita H. PMID: 39847088.
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FBP1 controls liver cancer evolution from senescent MASH hepatocytes. Nature. 2025 Jan; 637(8045):461-469.
Gu L, Zhu Y, Nandi SP, Lee M, Watari K, Bareng B, Ohira M, Liu Y, Sakane S, Carlessi R, Sauceda C, Dhar D, Ganguly S, Hosseini M, Teneche MG, Adams PD, Gonzalez DJ, Kisseleva T, Liver Cancer Collaborative, Tirnitz-Parker JEE, Simon MC, Alexandrov LB, Karin M. PMID: 39743585.
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1 Fields:
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HumansAnimalsCells
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Multi-modal analysis of human hepatic stellate cells identifies novel therapeutic targets for metabolic dysfunction-associated steatotic liver disease. J Hepatol. 2025 May; 82(5):882-897.
Kim HY, Rosenthal SB, Liu X, Miciano C, Hou X, Miller M, Buchanan J, Poirion OB, Chilin-Fuentes D, Han C, Housseini M, Carvalho-Gontijo Weber R, Sakane S, Lee W, Zhao H, Diggle K, Preissl S, Glass CK, Ren B, Wang A, Brenner DA, Kisseleva T. PMID: 39522884.
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1 Fields:
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HumansAnimalsCells
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Serum amyloid P (PTX2) attenuates hepatic fibrosis in mice by inhibiting the activation of fibrocytes and HSCs. Hepatol Commun. 2024 Nov 01; 8(11).
Cong M, Carvalho Gontijo Weber R, Sakane S, Zhang V, Jiang C, Taura K, Kodama Y, DeMinicis S, Ganguly S, Brafman D, Chien S, Kramer M, Lupher M, Brenner DA, Xu J, Kisseleva T. PMID: 39761005; PMCID: PMC11495776.
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HumansAnimalsCells
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Protocol to generate human liver spheroids to study liver fibrosis induced by metabolic stress. STAR Protoc. 2024 Jun 21; 5(2):103111.
Kim HY, Lee W, Liu X, Jang H, Sakane S, Carvalho-Gontijo Weber R, Diggle K, Kerk SA, Metallo CM, Kisseleva T, Brenner DA. PMID: 38833372; PMCID: PMC11179098.
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3 Fields:
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HumansCells
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Serum growth differentiation factor 15 is a novel biomarker with high predictive capability for liver cancer occurrence in patients with MASLD regardless of liver fibrosis. Aliment Pharmacol Ther. 2024 08; 60(3):327-339.
Kumazaki S, Hikita H, Tahata Y, Sung JH, Fukumoto K, Myojin Y, Sakane S, Murai K, Sasaki Y, Shirai K, Saito Y, Kodama T, Kakita N, Takahashi H, Toyoda H, Suda G, Morii E, Kojima T, Ebihara T, Shimizu K, Sasaki Y, Tatsumi T, Takehara T. PMID: 38828944.
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Humans
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Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD. Hepatol Commun. 2024 06 01; 8(6).
Sakane S, Hikita H, Shirai K, Sakamoto T, Narumi R, Adachi J, Kakita N, Yamada Y, Toyoda H, Takahashi H, Suda G, Kai M, Tahata Y, Sakamori R, Kumazaki S, Fukumoto K, Myojin Y, Murai K, Kodama T, Tatsumi T, Tomonaga T, Sakamoto N, Morii E, Takehara T. PMID: 38829196; PMCID: PMC11150025.
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5 Fields:
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HumansCells
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TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metab. 2024 May 07; 36(5):1030-1043.e7.
Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. PMID: 38670107; PMCID: PMC11113091.
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2 Fields:
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HumansAnimalsCells
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Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression. Biomolecules. 2024 Mar 27; 14(4).
Osna NA, Tikhanovich I, Ortega-Ribera M, Mueller S, Zheng C, Mueller J, Li S, Sakane S, Weber RCG, Kim HY, Lee W, Ganguly S, Kimura Y, Liu X, Dhar D, Diggle K, Brenner DA, Kisseleva T, Attal N, McKillop IH, Chokshi S, Mahato R, Rasineni K, Szabo G, Kharbanda KK. PMID: 38672422; PMCID: PMC11048648.
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3 Fields:
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HumansAnimalsCells
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The Origin and Fate of Liver Myofibroblasts. Cell Mol Gastroenterol Hepatol. 2024; 17(1):93-106.
Kim HY, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, Lam K, Ishizuka K, Rosenthal SB, Diggle K, Brenner DA, Kisseleva T. PMID: 37743012; PMCID: PMC10665929.
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14 Fields:
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HumansCells
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Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers. STAR Protoc. 2023 Sep 15; 4(3):102391.
Liu X, Lam K, Zhao H, Sakane S, Kim HY, Eguileor A, Diggle K, Wu S, Gontijo Weber RC, Soroosh P, Hosseini M, Mekeel K, Brenner DA, Kisseleva T. PMID: 37405925; PMCID: PMC10345194.
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1 Fields:
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HumansCells
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Fucosylated haptoglobin is a novel predictive marker of hepatocellular carcinoma after hepatitis C virus elimination in patients with advanced liver fibrosis. PLoS One. 2022; 17(12):e0279416.
Shirai K, Hikita H, Sakamori R, Doi A, Tahata Y, Sakane S, Kamada Y, Murai K, Nishio A, Yamada R, Kodama T, Nozaki Y, Kakita N, Ishida H, Nakanishi F, Morishita N, Imanaka K, Sakakibara M, Tatsumi T, Miyoshi E, Takehara T. PMID: 36542633; PMCID: PMC9770342.
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1 Fields:
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HumansCells
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Pentraxin 3 is an adipose tissue-related serum marker for pancreatic cancer cachexia predicting subsequent muscle mass and visceral fat loss. Cancer Sci. 2022 Dec; 113(12):4311-4326.
Sato K, Hikita H, Shigekawa M, Kato S, Sasaki Y, Shinkai K, Fukuoka M, Kudo S, Sato Y, Fukumoto K, Shirai K, Myojin Y, Sakane S, Murai K, Yoshioka T, Nishio A, Kodama T, Sakamori R, Tatsumi T, Takehara T. PMID: 36074525; PMCID: PMC9746057.
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5 Fields:
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Animals
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STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression. Cell Mol Gastroenterol Hepatol. 2023; 15(1):99-119.
Makino Y, Hikita H, Kato S, Sugiyama M, Shigekawa M, Sakamoto T, Sasaki Y, Murai K, Sakane S, Kodama T, Sakamori R, Kobayashi S, Eguchi H, Takemura N, Kokudo N, Yokoi H, Mukoyama M, Tatsumi T, Takehara T. PMID: 36210625; PMCID: PMC9672888.
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10 Fields:
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HumansAnimalsCells
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Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis. Cancer Res. 2022 08 16; 82(16):2860-2873.
Makino Y, Hikita H, Fukumoto K, Sung JH, Sakano Y, Murai K, Sakane S, Kodama T, Sakamori R, Kondo J, Kobayashi S, Tatsumi T, Takehara T. PMID: 35696550; PMCID: PMC9379366.
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19 Fields:
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AnimalsCells
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Serum amyloid P component and pro-platelet basic protein in extracellular vesicles or serum are novel markers of liver fibrosis in chronic hepatitis C patients. PLoS One. 2022; 17(7):e0271020.
Shirai K, Hikita H, Sakane S, Narumi R, Adachi J, Doi A, Tanaka S, Tahata Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Mita E, Tomonaga T, Takehara T. PMID: 35797333; PMCID: PMC9262231.
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6 Fields:
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HumansCells
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Letter: serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination-authors' reply. Aliment Pharmacol Ther. 2022 04; 55(8):1061-1062.
Myojin Y, Hikita H, Tahata Y, Doi A, Kato S, Sasaki Y, Shirai K, Sakane S, Yamada R, Kodama T, Hagiwara H, Imai Y, Hiramatsu N, Tamura S, Yamamoto K, Ohkawa K, Hijioka T, Fukui H, Doi Y, Yamada Y, Yakushijin T, Mita E, Sakamori R, Tatsumi T, Takehara T. PMID: 35362133.
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HumansCells
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Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination. Aliment Pharmacol Ther. 2022 02; 55(4):422-433.
Myojin Y, Hikita H, Tahata Y, Doi A, Kato S, Sasaki Y, Shirai K, Sakane S, Yamada R, Kodama T, Hagiwara H, Imai Y, Hiramatsu N, Tamura S, Yamamoto K, Ohkawa K, Hijioka T, Fukui H, Doi Y, Yamada Y, Yakushijin T, Mita E, Sakamori R, Tatsumi T, Takehara T. PMID: 34812502.
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6 Fields:
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HumansCells
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Hepatocellular Carcinoma in a Patient with Tetralogy of Fallot: A Case Report and Literature Review. Intern Med. 2022 May 01; 61(9):1361-1365.
Hyun Sung J, Sakamori R, Yamada R, Yoshioka T, Sakane S, Tahata Y, Shigekawa M, Kodama T, Hikita H, Tatsumi T, Takehara T. PMID: 34670885; PMCID: PMC9152848.
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2 Fields:
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Humans
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Activation of p53 After Irradiation Impairs the Regenerative Capacity of the Mouse Liver. Hepatol Commun. 2022 02; 6(2):411-422.
Urabe M, Hikita H, Saito Y, Kudo S, Fukumoto K, Mizutani N, Myojin Y, Doi A, Sato K, Sakane S, Makino Y, Kodama T, Sakamori R, Tatsumi T, Takehara T. PMID: 34585534; PMCID: PMC8793995.
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1 Fields:
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AnimalsCells
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Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis. Hepatology. 2021 11; 74(5):2452-2466.
Kozumi K, Kodama T, Murai H, Sakane S, Govaere O, Cockell S, Motooka D, Kakita N, Yamada Y, Kondo Y, Tahata Y, Yamada R, Hikita H, Sakamori R, Kamada Y, Daly AK, Anstee QM, Tatsumi T, Morii E, Takehara T. PMID: 34105780; PMCID: PMC8596693.
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50 Fields:
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HumansCells
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White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice. Cell Mol Gastroenterol Hepatol. 2021; 12(5):1683-1699.
Sakane S, Hikita H, Shirai K, Myojin Y, Sasaki Y, Kudo S, Fukumoto K, Mizutani N, Tahata Y, Makino Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T. PMID: 34303881; PMCID: PMC8551788.
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25 Fields:
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AnimalsCells
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Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis. Am J Physiol Gastrointest Liver Physiol. 2021 06 01; 320(6):G958-G968.
Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T. PMID: 33787344.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration. Sci Rep. 2021 02 09; 11(1):3363.
Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, Myojin Y, Doi A, Murai K, Sakane S, Saito Y, Kodama T, Sakamori R, Tatsumi T, Takehara T. PMID: 33564095; PMCID: PMC7873060.
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4 Fields:
Translation:
AnimalsCells
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Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production. Gastroenterology. 2021 04; 160(5):1741-1754.e16.
Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T. PMID: 33346004.
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61 Fields:
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HumansAnimalsCells
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Hepatitis C virus enhances Rubicon expression, leading to autophagy inhibition and intracellular innate immune activation. Sci Rep. 2020 09 17; 10(1):15290.
Shiode Y, Hikita H, Tanaka S, Shirai K, Doi A, Sakane S, Kai Y, Nakabori T, Yamada R, Kodama T, Narumi R, Sakamori R, Eguchi H, Tomonaga T, Tatsumi T, Takehara T. PMID: 32943718; PMCID: PMC7498609.
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PubMed Mentions:
13 Fields:
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HumansAnimalsCells
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Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels. PLoS One. 2020; 15(7):e0235573.
Sato K, Hikita H, Myojin Y, Fukumoto K, Murai K, Sakane S, Tamura T, Yamai T, Nozaki Y, Yoshioka T, Kodama T, Shigekawa M, Sakamori R, Tatsumi T, Takehara T. PMID: 32609742; PMCID: PMC7329089.
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11 Fields:
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HumansAnimalsCells
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Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice. Hepatology. 2016 12; 64(6):1994-2014.
Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T. PMID: 27637015.
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PubMed Mentions:
163 Fields:
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AnimalsCells
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Administration of low-dose epoetin-alpha facilitates adherence to ribavirin in triple therapy with pegylated interferon-alpha-2b and telaprevir. Hepatol Res. 2014 Oct; 44(10):E84-91.
Ishida H, Sakane S, Toyama T, Fukutomi K, Kimura K, Sugimoto A, Hibino K, Tamura T, Iwasaki T, Iwasaki R, Hasegawa H, Sakakibara Y, Yamada T, Nakazuru S, Mita E. PMID: 23957840.
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1
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Suprathreshold stochastic resonance in visual signal detection. Behav Brain Res. 2008 Nov 03; 193(1):152-5.
Sasaki H, Sakane S, Ishida T, Todorokihara M, Kitamura T, Aoki R. PMID: 18565603.
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Subthreshold noise facilitates the detection and discrimination of visual signals. Neurosci Lett. 2008 May 09; 436(2):255-8.
Sasaki H, Sakane S, Ishida T, Todorokihara M, Kitamura T, Aoki R. PMID: 18400398.
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8 Fields:
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HumansCellsPHPublic Health
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A colorimetric assay for studying effector secretion through the bacterial type III secretion system. FEMS Microbiol Lett. 2008 Jan; 278(1):36-42.
Miyake M, Sakane S, Kobayashi C, Hanajima-Ozawa M, Fukui A, Kamitani S, Horiguchi Y. PMID: 17995954.
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PubMed Mentions:
1 Fields:
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HumansCells