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Sunil Advani

Title(s)Associate Professor, Radiation Medicine and Applied Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0861
La Jolla CA 92093
Phone8/8-22--7574
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    Collapse Research 
    Collapse Research Activities and Funding
    Elucidation and therapeutic exploitation of PAK mediated radioresistance
    NIH/NCI R01CA215081Dec 18, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Elucidation and therapeutic exploitation of PAK mediated radioresistance
    NIH/NCI R37CA215081Dec 18, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Developing targeted activatable peptides to amplify radiosensitizer delivery
    NIH/NCI R03CA219744Aug 15, 2017 - Jul 31, 2019
    Role: Principal Investigator
    Restricting radiosensitization through ErbB targeted antibody drug conjugates
    NIH/NCI R21CA205765Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors. Biomaterials. 2020 Jul; 248:120032. Hingorani DV, Crisp JL, Doan MK, Camargo MF, Quraishi MA, Aguilera J, Gilardi M, Gross LA, Jiang T, Li WT, Ongkeko WM, Cohen EEW, Gutkind JS, Adams SR, Advani SJ. PMID: 32304937.
      View in: PubMed   Mentions:    Fields:    
    2. Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability. Mol Cancer Ther. 2020 01; 19(1):157-167. Hingorani DV, Doan MK, Camargo MF, Aguilera J, Song SM, Pizzo D, Scanderbeg DJ, Cohen EEW, Lowy AM, Adams SR, Advani SJ. PMID: 31597712.
      View in: PubMed   Mentions: 1     Fields:    
    3. An in vitro study for the dosimetric and radiobiological validation of respiratory gating in conventional and hypofractionated radiotherapy of the lung: effect of dose, dose rate, and breathing pattern. Phys Med Biol. 2019 07 04; 64(13):135009. Cerviño LI, Soultan D, Advani SJ, Cornell M, Yock A, Pettersson N, Song WY, Aguilera J, Murphy J, Hoh C, James C, Paravati A, Coope R, Gill B, Moiseenko V. PMID: 31189137.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Radiation-Drug Combinations to Improve Clinical Outcomes and Reduce Normal Tissue Toxicities: Current Challenges and New Approaches: Report of the Symposium Held at the 63rd Annual Meeting of the Radiation Research Society, 15-18 October 2017; Cancun, Mexico. Radiat Res. 2018 10; 190(4):350-360. Falls KC, Sharma RA, Lawrence YR, Amos RA, Advani SJ, Ahmed MM, Vikram B, Coleman CN, Prasanna PG. PMID: 30280985.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. A novel 3D-printed phantom insert for 4D PET/CT imaging and simultaneous integrated boost radiotherapy. Med Phys. 2017 Oct; 44(10):5467-5474. Cerviño L, Soultan D, Cornell M, Yock A, Pettersson N, Song WY, Aguilera J, Advani S, Murphy J, Hoh C, James C, Paravati A, Coope R, Gill B, Moiseenko V. PMID: 28766726.
      View in: PubMed   Mentions: 1     Fields:    
    6. Phase I Trial of Intravenous Oncolytic Vaccinia Virus (GL-ONC1) with Cisplatin and Radiotherapy in Patients with Locoregionally Advanced Head and Neck Carcinoma. Clin Cancer Res. 2017 Oct 01; 23(19):5696-5702. Mell LK, Brumund KT, Daniels GA, Advani SJ, Zakeri K, Wright ME, Onyeama SJ, Weisman RA, Sanghvi PR, Martin PJ, Szalay AA. PMID: 28679776.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsCTClinical Trials
    7. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun. 2016 11 25; 7:13597. Wilson R, Espinosa-Diez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, Advani SJ, Li J, Khan OF, Franovic A, Weis SM, Kumar S, Coussens LM, Anderson DG, Chen CC, Cheresh DA, Anand S. PMID: 27886180.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    8. Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nat Commun. 2016 10 04; 7:13019. Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ. PMID: 27698471.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016 Jan; 52:58-65. Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander LE, Brumund KT, Wang-Rodriguez J, Ongkeko WM. PMID: 26547127.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    10. Kinase-independent role for CRAF-driving tumour radioresistance via CHK2. Nat Commun. 2015 Sep 03; 6:8154. Advani SJ, Camargo MF, Seguin L, Mielgo A, Anand S, Hicks AM, Aguilera J, Franovic A, Weis SM, Cheresh DA. PMID: 26333361.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Clinical and cosmetic outcomes in patients treated with high-dose-rate electronic brachytherapy for nonmelanoma skin cancer. Pract Radiat Oncol. 2015 Nov-Dec; 5(6):e659-64. Paravati AJ, Hawkins PG, Martin AN, Mansy G, Rahn DA, Advani SJ, Hoisak J, Dragojevic I, Martin PJ, Miller CJ, Sanghvi P. PMID: 26432680.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    12. Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncol. 2015 May; 51(5):470-5. Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT. PMID: 25735654.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. PMID: 25681274.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Combination of fractionated irradiation with anti-VEGF expressing vaccinia virus therapy enhances tumor control by simultaneous radiosensitization of tumor associated endothelium. Int J Cancer. 2013 Dec 15; 133(12):2989-99. Buckel L, Advani SJ, Frentzen A, Zhang Q, Yu YA, Chen NG, Ehrig K, Stritzker J, Mundt AJ, Szalay AA. PMID: 23729266.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    15. Preferential replication of systemically delivered oncolytic vaccinia virus in focally irradiated glioma xenografts. Clin Cancer Res. 2012 May 01; 18(9):2579-90. Advani SJ, Buckel L, Chen NG, Scanderbeg DJ, Geissinger U, Zhang Q, Yu YA, Aguilar RJ, Mundt AJ, Szalay AA. PMID: 22379115.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    16. A MEK-independent role for CRAF in mitosis and tumor progression. Nat Med. 2011 Nov 13; 17(12):1641-5. Mielgo A, Seguin L, Huang M, Camargo MF, Anand S, Franovic A, Weis SM, Advani SJ, Murphy EA, Cheresh DA. PMID: 22081024.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    17. DNA damage response and repair: insights into strategies for radiation sensitization of gliomas. Future Oncol. 2011 Nov; 7(11):1335-46. Kesari S, Advani SJ, Lawson JD, Kahle KT, Ng K, Carter B, Chen CC. PMID: 22044206.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    18. Increased oncolytic efficacy for high-grade gliomas by optimal integration of ionizing radiation into the replicative cycle of HSV-1. Gene Ther. 2011 Nov; 18(11):1098-102. Advani SJ, Markert JM, Sood RF, Samuel S, Gillespie GY, Shao MY, Roizman B, Weichselbaum RR. PMID: 21544094.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. Enhancing radiotherapy with genetically engineered viruses. J Clin Oncol. 2007 Sep 10; 25(26):4090-5. Advani SJ, Weichselbaum RR, Chmura SJ. PMID: 17827458.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. ReVOLT: radiation-enhanced viral oncolytic therapy. Int J Radiat Oncol Biol Phys. 2006 Nov 01; 66(3):637-46. Advani SJ, Mezhir JJ, Roizman B, Weichselbaum RR. PMID: 17011442.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses. Cancer Res. 2005 Oct 15; 65(20):9479-84. Mezhir JJ, Advani SJ, Smith KD, Darga TE, Poon AP, Schmidt H, Posner MC, Roizman B, Weichselbaum RR. PMID: 16230412.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    22. The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1. J Virol. 2005 Jun; 79(11):6757-62. Durand LO, Advani SJ, Poon AP, Roizman B. PMID: 15890914.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    23. Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1. J Virol. 2003 Nov; 77(22):11927-32. Advani SJ, Durand LO, Weichselbaum RR, Roizman B. PMID: 14581529.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus. J Vasc Surg. 2003 Jun; 37(6):1294-300. Curi MA, Skelly CL, Meyerson SL, Baldwin ZK, Balasubramanian V, Advani SJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. PMID: 12764278.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4825-30. Advani SJ, Weichselbaum RR, Roizman B. PMID: 12665617.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    26. Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications. Clin Microbiol Infect. 2002 Sep; 8(9):551-63. Advani SJ, Weichselbaum RR, Whitley RJ, Roizman B. PMID: 12427216.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma. Gene Ther. 2002 Jan; 9(1):75-80. Chung SM, Advani SJ, Bradley JD, Kataoka Y, Vashistha K, Yan SY, Markert JM, Gillespie GY, Whitley RJ, Roizman B, Weichselbaum RR. PMID: 11850725.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    28. Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo. Gene Ther. 2001 Dec; 8(24):1840-6. Skelly CL, Curi MA, Meyerson SL, Woo DH, Hari D, Vosicky JE, Advani SJ, Mauceri HJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. PMID: 11821937.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. cdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factor. J Virol. 2001 Nov; 75(21):10326-33. Advani SJ, Weichselbaum RR, Roizman B. PMID: 11581401.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    30. Prospects for viral-based strategies enhancing the anti-tumor effects of ionizing radiation. Semin Radiat Oncol. 2001 Oct; 11(4):338-45. Chmura SJ, Gupta N, Advani SJ, Kufe DW, Weichselbaum RR. PMID: 11677658.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize. J Virol. 2001 Sep; 75(17):7904-12. Advani SJ, Hagglund R, Weichselbaum RR, Roizman B. PMID: 11483735.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    32. Role of cyclin D3 in the biology of herpes simplex virus 1 ICPO. J Virol. 2001 Feb; 75(4):1888-98. Van Sant C, Lopez P, Advani SJ, Roizman B. PMID: 11160688.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    33. Molecular targeting of gene therapy and radiotherapy. Acta Oncol. 2001; 40(6):735-8. Weichselbaum RR, Kufe DW, Advani SJ, Roizman B. PMID: 11765068.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    34. The role of cdc2 in the expression of herpes simplex virus genes. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10996-1001. Advani SJ, Weichselbaum RR, Roizman B. PMID: 10995483.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    35. E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1. J Virol. 2000 Sep; 74(17):7842-50. Advani SJ, Weichselbaum RR, Roizman B. PMID: 10933691.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    36. The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes. J Virol. 2000 Jan; 74(1):8-15. Advani SJ, Brandimarti R, Weichselbaum RR, Roizman B. PMID: 10590085.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    37. Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):12062-7. Khodarev NN, Advani SJ, Gupta N, Roizman B, Weichselbaum RR. PMID: 10518576.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    38. Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. Cancer Res. 1999 May 01; 59(9):2055-8. Advani SJ, Chung SM, Yan SY, Gillespie GY, Markert JM, Whitley RJ, Roizman B, Weichselbaum RR. PMID: 10232586.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    39. Strategies for enhancing viral-based gene therapy using ionizing radiation. Radiat Oncol Investig. 1999; 7(5):261-9. Chmura SJ, Advani SJ, Kufe DW, Weichselbaum RR. PMID: 10580895.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    40. Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors. Gene Ther. 1998 Feb; 5(2):160-5. Advani SJ, Sibley GS, Song PY, Hallahan DE, Kataoka Y, Roizman B, Weichselbaum RR. PMID: 9578834.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    41. Radiogenetic therapy: on the interaction of viral therapy and ionizing radiation for improving local control of tumors. Semin Oncol. 1997 Dec; 24(6):633-8. Advani SJ, Chmura SJ, Weichselbaum RR. PMID: 9422260.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells