Prashant Mali
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Title(s) | Associate Professor, Bioengineering |
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School | Vc-academic Affairs |
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Address | 9500 Gilman Drive # La Jolla CA 92093
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vCard | Download vCard |
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Research ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Synthetic Lethal Screens Reveal Co-Targeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma. Clin Cancer Res. 2021 Feb 10.
PMID: 33568347.
View in: PubMed Mentions: Fields:
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Defining the Teratoma as a Model for Multi-lineage Human Development. Cell. 2020 Nov 25; 183(5):1402-1419.e18.
McDonald D, Wu Y, Dailamy A, Tat J, Parekh U, Zhao D, Hu M, Tipps A, Zhang K, Mali P. PMID: 33152263.
View in: PubMed Mentions: Fields:
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Translating CRISPR-Cas Therapeutics: Approaches and Challenges. CRISPR J. 2020 08; 3(4):253-275.
Tay LS, Palmer N, Panwala R, Chew WL, Mali P. PMID: 32833535.
View in: PubMed Mentions: 1 Fields:
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Mapping regulators of cell fate determination: Approaches and challenges. APL Bioeng. 2020 Sep; 4(3):031501.
Kumar A, Mali P. PMID: 32637855.
View in: PubMed Mentions:
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CRISPR-Cas9 Gene Editing of Hematopoietic Stem Cells from Patients with Friedreich's Ataxia. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:1026-1036.
Rocca CJ, Rainaldi JN, Sharma J, Shi Y, Haquang JH, Luebeck J, Mali P, Cherqui S. PMID: 32462051.
View in: PubMed Mentions:
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Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy. Nat Biomed Eng. 2019 10; 3(10):806-816.
Moreno AM, Palmer N, Alemán F, Chen G, Pla A, Jiang N, Leong Chew W, Law M, Mali P. PMID: 31332341.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Humanizing Transcriptome Engineering. Cell. 2019 06 27; 178(1):8-9.
Mali P. PMID: 31251918.
View in: PubMed Mentions: Fields: Translation: HumansCells
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RNA-Guided Adenosine Deaminases: Advances and Challenges for Therapeutic RNA Editing. Biochemistry. 2019 04 16; 58(15):1947-1957.
Chen G, Katrekar D, Mali P. PMID: 30943016.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. Nat Methods. 2019 03; 16(3):239-242.
Katrekar D, Chen G, Meluzzi D, Ganesh A, Worlikar A, Shih YR, Varghese S, Mali P. PMID: 30737497.
View in: PubMed Mentions: 15 Fields: Translation: HumansAnimalsCells
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Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays. J Vis Exp. 2019 01 07; (143).
Deshpande A, Chen BR, Zhao L, Saddoris K, Kerr M, Zhu N, Mali P, Deshpande AJ. PMID: 30663717.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout. Cell Syst. 2018 11 28; 7(5):548-555.e8.
Parekh U, Wu Y, Zhao D, Worlikar A, Shah N, Zhang K, Mali P. PMID: 30448000.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Facile Engineering of Long-Term Culturable Ex Vivo Vascularized Tissues Using Biologically Derived Matrices. Adv Healthc Mater. 2018 12; 7(23):e1800845.
Hu M, Dailamy A, Lei XY, Parekh U, McDonald D, Kumar A, Mali P. PMID: 30369101.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Developmental barcoding of whole mouse via homing CRISPR. Science. 2018 08 31; 361(6405).
Kalhor R, Kalhor K, Mejia L, Leeper K, Graveline A, Mali P, Church GM. PMID: 30093604.
View in: PubMed Mentions: 29 Fields: Translation: AnimalsCells
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Functional Genomics via CRISPR-Cas. J Mol Biol. 2019 01 04; 431(1):48-65.
Ford K, McDonald D, Mali P. PMID: 29959923.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation. Mol Ther. 2018 07 05; 26(7):1818-1827.
Moreno AM, Fu X, Zhu J, Katrekar D, Shih YV, Marlett J, Cabotaje J, Tat J, Naughton J, Lisowski L, Varghese S, Zhang K, Mali P. PMID: 29754775.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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Oligonucleotide conjugated multi-functional adeno-associated viruses. Sci Rep. 2018 02 26; 8(1):3589.
Katrekar D, Moreno AM, Chen G, Worlikar A, Mali P. PMID: 29483550.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Mol Cell. 2018 02 15; 69(4):699-708.e7.
Zhao D, Badur MG, Luebeck J, Magaña JH, Birmingham A, Sasik R, Ahn CS, Ideker T, Metallo CM, Mali P. PMID: 29452643.
View in: PubMed Mentions: 10 Fields: Translation: HumansCells
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The future of genome editing. Cell. 2018; (173):1311-1313.
Pawluk A, Chen J, Ji W, Mali P. .
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Corrigendum: Engineering and optimising deaminase fusions for genome editing. Nat Commun. 2017 10 09; 8:16169.
Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. PMID: 28991237.
View in: PubMed Mentions: Fields:
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Genetic interaction mapping in mammalian cells using CRISPR interference. Nat Methods. 2017 Jun; 14(6):577-580.
Du D, Roguev A, Gordon DE, Chen M, Chen SH, Shales M, Shen JP, Ideker T, Mali P, Qi LS, Krogan NJ. PMID: 28481362.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Nat Methods. 2017 Jun; 14(6):573-576.
Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. PMID: 28319113.
View in: PubMed Mentions: 62 Fields: Translation: HumansCells
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Therapeutic genome engineering via CRISPR-Cas systems. Wiley Interdiscip Rev Syst Biol Med. 2017 07; 9(4).
Moreno AM, Mali P. PMID: 28198142.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimals
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malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication. PLOS Medicine. 2017.
The malERA Refresh Consultative Panel on Basic Science and Enabling Technologies.
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Genome engineering in human pluripotent stem cells. Current Opinion in Chemical Engineering. 2017; (15):56-67.
Parekh U, Yusupova M, Mali P. .
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Advances in CRISPR-Cas based genome engineering. Current Opinion in Biomedical Engineering. 2017; (1):78-86.
Katrekar D, Hu M, Mali P. .
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Genome engineering via CRISPR-Cas systems: inserting the 'precision' in precision medicine. The Journal of Precision Medicine. 2017.
Asudani D, Yusupova M, Mali P. .
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Rapidly evolving homing CRISPR barcodes. Nat Methods. 2017 02; 14(2):195-200.
Kalhor R, Mali P, Church GM. PMID: 27918539.
View in: PubMed Mentions: 29 Fields: Translation: HumansCells
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Engineering and optimising deaminase fusions for genome editing. Nat Commun. 2016 11 02; 7:13330.
Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. PMID: 27804970.
View in: PubMed Mentions: 20 Fields: Translation: HumansCells
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A multifunctional AAV-CRISPR-Cas9 and its host response. Nat Methods. 2016 10; 13(10):868-74.
Chew WL, Tabebordbar M, Cheng JK, Mali P, Wu EY, Ng AH, Zhu K, Wagers AJ, Church GM. PMID: 27595405.
View in: PubMed Mentions: 114 Fields: Translation: HumansAnimalsCells
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CRISPR-Cas: A laboratory manual. Cold Spring Harbor Laboratory Press. 2016.
Doudna J, Mali P. .
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Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach. Nat Methods. 2015 Sep; 12(9):823-6.
Chari R, Mali P, Moosburner M, Church GM. PMID: 26167643.
View in: PubMed Mentions: 105 Fields: Translation: HumansCells
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Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells. Nucleic Acids Res. 2015 Feb 18; 43(3):e21.
Byrne SM, Ortiz L, Mali P, Aach J, Church GM. PMID: 25414332.
View in: PubMed Mentions: 52 Fields: Translation: HumansCells
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Highly multiplexed subcellular RNA sequencing in situ. Science. 2014 Mar 21; 343(6177):1360-3.
Lee JH, Daugharthy ER, Scheiman J, Kalhor R, Yang JL, Ferrante TC, Terry R, Jeanty SS, Li C, Amamoto R, Peters DT, Turczyk BM, Marblestone AH, Inverso SA, Bernard A, Mali P, Rios X, Aach J, Church GM. PMID: 24578530.
View in: PubMed Mentions: 221 Fields: Translation: HumansCells
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CasFinder: Flexible algorithm for identifying specific Cas9 targets in genomes. bioRxiv. 2014.
Aach J, Mali P, Church GM.
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CRISPR-Cas-mediated targeted genome editing in human cells. Methods Mol Biol. 2014; 1114:245-67.
Yang L, Mali P, Kim-Kiselak C, Church G. PMID: 24557908.
View in: PubMed Mentions: 21 Fields: Translation: HumansCells
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Genome editing in human stem cells. Methods Enzymol. 2014; 546:119-38.
Byrne SM, Mali P, Church GM. PMID: 25398338.
View in: PubMed Mentions: 33 Fields: Translation: HumansCells
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Cas9 as a versatile tool for engineering biology. Nat Methods. 2013 Oct; 10(10):957-63.
Mali P, Esvelt KM, Church GM. PMID: 24076990.
View in: PubMed Mentions: 417 Fields: Translation: Cells
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Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods. 2013 Nov; 10(11):1116-21.
Esvelt KM, Mali P, Braff JL, Moosburner M, Yaung SJ, Church GM. PMID: 24076762.
View in: PubMed Mentions: 284 Fields: Translation: Cells
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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol. 2013 Sep; 31(9):833-8.
PMID: 23907171.
View in: PubMed Mentions: 630 Fields: Translation: HumansCells
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Optimization of scarless human stem cell genome editing. Nucleic Acids Res. 2013 Oct; 41(19):9049-61.
Yang L, Guell M, Byrne S, Yang JL, De Los Angeles A, Mali P, Aach J, Kim-Kiselak C, Briggs AW, Rios X, Huang PY, Daley G, Church G. PMID: 23907390.
View in: PubMed Mentions: 150 Fields: Translation: HumansCells
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Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):12601-6.
Kusuma S, Shen YI, Hanjaya-Putra D, Mali P, Cheng L, Gerecht S. PMID: 23858432.
View in: PubMed Mentions: 63 Fields: Translation: HumansCells
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Barcoding cells using cell-surface programmable DNA-binding domains. Nat Methods. 2013 May; 10(5):403-6.
Mali P, Aach J, Lee JH, Levner D, Nip L, Church GM. PMID: 23503053.
View in: PubMed Mentions: 19 Fields: Translation: Cells
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Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res. 2013 Apr; 41(7):4336-43.
DiCarlo JE, Norville JE, Mali P, Rios X, Aach J, Church GM. PMID: 23460208.
View in: PubMed Mentions: 418 Fields: Translation: AnimalsCells
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RNA-guided human genome engineering via Cas9. Science. 2013 Feb 15; 339(6121):823-6.
Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM. PMID: 23287722.
View in: PubMed Mentions: 2765 Fields: Translation: HumansCells
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Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res. 2012 Aug; 40(15):e117.
Briggs AW, Rios X, Chari R, Yang L, Zhang F, Mali P, Church GM. PMID: 22740649.
View in: PubMed Mentions: 77 Fields: Translation: HumansCells
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The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells. PLoS One. 2012; 7(5):e36689.
PMID: 22574215.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Efficient derivation and genetic modifications of human pluripotent stem cells on engineered human feeder cell lines. Stem Cells Dev. 2012 Aug 10; 21(12):2298-311.
Zou C, Chou BK, Dowey SN, Tsang K, Huang X, Liu CF, Smith C, Yen J, Mali P, Zhang YA, Cheng L, Ye Z. PMID: 22225458.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Concise review: Human cell engineering: cellular reprogramming and genome editing. Stem Cells. 2012 Jan; 30(1):75-81.
Mali P, Cheng L. PMID: 21905170.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood. 2011 Oct 27; 118(17):4599-608.
Zou J, Mali P, Huang X, Dowey SN, Cheng L. PMID: 21881051.
View in: PubMed Mentions: 141 Fields: Translation: HumansAnimalsCells
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Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res. 2011 Mar; 21(3):518-29.
Chou BK, Mali P, Huang X, Ye Z, Dowey SN, Resar LM, Zou C, Zhang YA, Tong J, Cheng L. PMID: 21243013.
View in: PubMed Mentions: 176 Fields: Translation: HumansCells
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Interplay of RhoA and motility in the programmed spreading of daughter cells postmitosis. Biophys J. 2010 Dec 01; 99(11):3526-34.
Mali P, Wirtz D, Searson PC. PMID: 21112276.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem Cells. 2010 Oct; 28(10):1893-904.
Swistowski A, Peng J, Liu Q, Mali P, Rao MS, Cheng L, Zeng X. PMID: 20715183.
View in: PubMed Mentions: 106 Fields: Translation: HumansCells
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Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells. Cancer Res. 2010 Oct 01; 70(19):7662-73.
Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, Yu W, Matsui W, Van Criekinge W, Rassool FV, Zambidis E, Schuebel KE, Cope L, Yen J, Mohammad HP, Cheng L, Baylin SB. PMID: 20841480.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
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Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr; 28(4):713-20.
Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L. PMID: 20201064.
View in: PubMed Mentions: 178 Fields: Translation: HumansCells
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An improved method for generating and identifying human induced pluripotent stem cells. Methods Mol Biol. 2010; 636:191-205.
Mali P, Ye Z, Chou BK, Yen J, Cheng L. PMID: 20336524.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood. 2009 Dec 24; 114(27):5473-80.
Ye Z, Zhan H, Mali P, Dowey S, Williams DM, Jang YY, Dang CV, Spivak JL, Moliterno AR, Cheng L. PMID: 19797525.
View in: PubMed Mentions: 155 Fields: Translation: HumansAnimalsCells
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Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell. 2009 Jul 02; 5(1):97-110.
Zou J, Maeder ML, Mali P, Pruett-Miller SM, Thibodeau-Beganny S, Chou BK, Chen G, Ye Z, Park IH, Daley GQ, Porteus MH, Joung JK, Cheng L. PMID: 19540188.
View in: PubMed Mentions: 234 Fields: Translation: HumansCells
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Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells. 2008 Aug; 26(8):1998-2005.
Mali P, Ye Z, Hommond HH, Yu X, Lin J, Chen G, Zou J, Cheng L. PMID: 18511599.
View in: PubMed Mentions: 112 Fields: Translation: HumansAnimalsCells
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Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment. Cell Stem Cell. 2008 May 08; 2(5):461-71.
Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li YM, Civin C, Gaiano N, Cheng L. PMID: 18462696.
View in: PubMed Mentions: 44 Fields: Translation: HumansCells
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Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. Cell Stem Cell. 2008 Apr 10; 2(4):345-55.
Chen G, Ye Z, Yu X, Zou J, Mali P, Brodsky RA, Cheng L. PMID: 18397754.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions. Cell Res. 2007 Jan; 17(1):62-72.
Cai L, Ye Z, Zhou BY, Mali P, Zhou C, Cheng L. PMID: 17211448.
View in: PubMed Mentions: 38 Fields: Translation: HumansCells
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Electrochemical template synthesis of multisegment nanowires: fabrication and protein functionalization. Langmuir. 2006 Dec 05; 22(25):10528-34.
Wildt B, Mali P, Searson PC. PMID: 17129026.
View in: PubMed Mentions: 3 Fields: Translation: Cells
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Electrochemically programmed release of biomolecules and nanoparticles. . 2006 Jun; 6(6):1250-3.
Mali P, Bhattacharjee N, Searson PC. PMID: 16771589.
View in: PubMed Mentions:
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Facile fabrication of microfluidic systems using electron beam lithography. Lab Chip. 2006 Feb; 6(2):310-5.
Mali P, Sarkar A, Lal R. PMID: 16450043.
View in: PubMed Mentions: 1 Fields:
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The dnaSET: A novel device for single-molecule DNA sequencing. IEEE Transactions on Electron Devices. 2004; (51):2004-2012.
Mali P, Lal R.
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Year | Publications |
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2004 | 1 | 2006 | 3 | 2007 | 1 | 2008 | 3 | 2009 | 2 | 2010 | 5 | 2011 | 2 | 2012 | 4 | 2013 | 8 | 2014 | 5 | 2015 | 1 | 2016 | 4 | 2017 | 8 | 2018 | 8 | 2019 | 5 | 2020 | 4 | 2021 | 1 |
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Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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