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Prashant Mali

Title(s)Assistant Researcher, Bioengineering
SchoolAcademic Aff
Phone858-822-5794
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    Dissecting the interplay of gene regulatory networks and cellular niche on cell fate determination
    NIH/NIGMS R01GM123313May 1, 2018 - Apr 30, 2022
    Role: Principal Investigator
    Systematic mapping of genetic vulnerabilities in head and neck cancer
    NIH/NCI R01CA222826Dec 18, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Next-generation Functional Genetic Screening of Un-screenable Traits
    NIH/NHGRI R01HG009285Aug 25, 2017 - Jul 31, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Moreno AM, Palmer N, Alemán F, Chen G, Pla A, Jiang N, Chew WL, Law M, Mali P. Author Correction: Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy. Nat Biomed Eng. 2019 Aug 27. PMID: 31455920.
      View in: PubMed
    2. Moreno AM, Palmer N, Alemán F, Chen G, Pla A, Jiang N, Leong Chew W, Law M, Mali P. Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy. Nat Biomed Eng. 2019 Jul 22. PMID: 31332341.
      View in: PubMed
    3. Mali P. Humanizing Transcriptome Engineering. Cell. 2019 Jun 27; 178(1):8-9. PMID: 31251918.
      View in: PubMed
    4. Chen G, Katrekar D, Mali P. RNA-Guided Adenosine Deaminases: Advances and Challenges for Therapeutic RNA Editing. Biochemistry. 2019 Apr 16; 58(15):1947-1957. PMID: 30943016.
      View in: PubMed
    5. Katrekar D, Chen G, Meluzzi D, Ganesh A, Worlikar A, Shih YR, Varghese S, Mali P. In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. Nat Methods. 2019 03; 16(3):239-242. PMID: 30737497.
      View in: PubMed
    6. Deshpande A, Chen BR, Zhao L, Saddoris K, Kerr M, Zhu N, Mali P, Deshpande AJ. Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays. J Vis Exp. 2019 Jan 07; (143). PMID: 30663717.
      View in: PubMed
    7. Parekh U, Wu Y, Zhao D, Worlikar A, Shah N, Zhang K, Mali P. Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout. Cell Syst. 2018 Nov 28; 7(5):548-555.e8. PMID: 30448000.
      View in: PubMed
    8. Hu M, Dailamy A, Lei XY, Parekh U, McDonald D, Kumar A, Mali P. Facile Engineering of Long-Term Culturable Ex Vivo Vascularized Tissues Using Biologically Derived Matrices. Adv Healthc Mater. 2018 Dec; 7(23):e1800845. PMID: 30369101.
      View in: PubMed
    9. Ford K, McDonald D, Mali P. Functional Genomics via CRISPR-Cas. J Mol Biol. 2019 Jan 04; 431(1):48-65. PMID: 29959923.
      View in: PubMed
    10. Moreno AM, Fu X, Zhu J, Katrekar D, Shih YV, Marlett J, Cabotaje J, Tat J, Naughton J, Lisowski L, Varghese S, Zhang K, Mali P. In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation. Mol Ther. 2018 07 05; 26(7):1818-1827. PMID: 29754775.
      View in: PubMed
    11. Katrekar D, Moreno AM, Chen G, Worlikar A, Mali P. Oligonucleotide conjugated multi-functional adeno-associated viruses. Sci Rep. 2018 Feb 26; 8(1):3589. PMID: 29483550.
      View in: PubMed
    12. Zhao D, Badur MG, Luebeck J, Magaña JH, Birmingham A, Sasik R, Ahn CS, Ideker T, Metallo CM, Mali P. Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Mol Cell. 2018 02 15; 69(4):699-708.e7. PMID: 29452643.
      View in: PubMed
    13. Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. Corrigendum: Engineering and optimising deaminase fusions for genome editing. Nat Commun. 2017 10 09; 8:16169. PMID: 28991237.
      View in: PubMed
    14. Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Nat Methods. 2017 Jun; 14(6):573-576. PMID: 28319113.
      View in: PubMed
    15. Moreno AM, Mali P. Therapeutic genome engineering via CRISPR-Cas systems. Wiley Interdiscip Rev Syst Biol Med. 2017 07; 9(4). PMID: 28198142.
      View in: PubMed
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