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Ratneshwar Lal

Title(s)Professor, Mechanical and Aerospace Engineering
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    Designing array-AFM to study cellular interactions mediating transmission and progression of AD pathophysiology in brain
    NIH R56AG058069Sep 30, 2018 - May 31, 2021
    Role: Principal Investigator
    Designing an Integrated Nanoscale System for Ion Channel Structure-Function Study
    NIH R01DA025296Jul 15, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Amyloid ion channels to design therapeutics for neurodegenerative diseases
    NIH R01AG028709Sep 15, 2006 - Feb 29, 2020
    Role: Principal Investigator
    Cytoskeletal Regulation of Lung Endothelial Pathobiology
    NIH P01HL058064Feb 1, 1998 - Jan 31, 2014
    Role: Co-Investigator
    Structure, Activity & Physiological Role of Hemichannels
    NIH R01DA024871Sep 1, 1997 - Aug 31, 2014
    Role: Principal Investigator
    Structure, Activity &Physiological Role of Hemichannels
    NIH R01GM056290Sep 1, 1997 - Apr 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The impact and future of artificial intelligence in medical genetics and molecular medicine: an ongoing revolution. Funct Integr Genomics. 2024 Aug 16; 24(4):138. Ozcelik F, Dundar MS, Yildirim AB, Henehan G, Vicente O, Sánchez-Alcázar JA, Gokce N, Yildirim DT, Bingol NN, Karanfilska DP, Bertelli M, Pojskic L, Ercan M, Kellermayer M, Sahin IO, Greiner-Tollersrud OK, Tan B, Martin D, Marks R, Prakash S, Yakubi M, Beccari T, Lal R, Temel SG, Fournier I, Ergoren MC, Mechler A, Salzet M, Maffia M, Danalev D, Sun Q, Nei L, Matulis D, Tapaloaga D, Janecke A, Bown J, Cruz KS, Radecka I, Ozturk C, Nalbantoglu OU, Sag SO, Ko K, Arngrimsson R, Belo I, Akalin H, Dundar M. PMID: 39147901.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    2. The structure of tyrosine-10 favors ionic conductance of Alzheimer's disease-associated full-length amyloid-β channels. Nat Commun. 2024 Feb 13; 15(1):1296. Karkisaval AG, Hassan R, Nguyen A, Balster B, Abedin F, Lal R, Tatulian SA. PMID: 38351257; PMCID: PMC10864385.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor. Proc Natl Acad Sci U S A. 2023 11 21; 120(47):e2311565120. Bodily TA, Ramanathan A, Wei S, Karkisaval A, Bhatt N, Jerez C, Haque MA, Ramil A, Heda P, Wang Y, Kumar S, Leite M, Li T, Zhao J, Lal R. PMID: 37956285; PMCID: PMC10666025.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    4. A Machine Learning Approach to COVID-19 Detection via Graphene Field-Effect-Transistor (GFET). Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-4. Tsui D, Downey F, Navaneethan S, Paul A, Bodily T, Lee M, Xu Y, Lal R, Cauwenberghs G. PMID: 38083446.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    5. Bacterial surface interactions with organic colloidal particles: Nanoscale hotspots of organic matter in the ocean. PLoS One. 2022; 17(8):e0272329. Patel N, Guillemette R, Lal R, Azam F. PMID: 36006971; PMCID: PMC9409529.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Rapid self-test of unprocessed viruses of SARS-CoV-2 and its variants in saliva by portable wireless graphene biosensor. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2206521119. Ban DK, Bodily T, Karkisaval AG, Dong Y, Natani S, Ramanathan A, Ramil A, Srivastava S, Bandaru P, Glinsky G, Lal R. PMID: 35763566; PMCID: PMC9282385.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    7. Heme Oxygenase-1 at the Nexus of Endothelial Cell Fate Decision Under Oxidative Stress. Front Cell Dev Biol. 2021; 9:702974. Raghunandan S, Ramachandran S, Ke E, Miao Y, Lal R, Chen ZB, Subramaniam S. PMID: 34595164; PMCID: PMC8476872.
      View in: PubMed   Mentions: 7  
    8. Scavenging amyloid oligomers from neurons with silica nanobowls: Implications for amyloid diseases. Biophys J. 2021 08 17; 120(16):3329-3340. Sant V, Som M, Karkisaval AG, Carnahan P, Lal R. PMID: 34242592; PMCID: PMC8391079.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Lipid-Encapsulated Silica Nanobowls as an Efficient and Versatile DNA Delivery System. Bioconjug Chem. 2020 12 16; 31(12):2697-2711. Som M, Lal R, Ruiz-Velasco V. PMID: 33232129.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Metamaterial-Assisted Photobleaching Microscopy with Nanometer Scale Axial Resolution. Nano Lett. 2020 08 12; 20(8):6038-6044. Lee YU, Zhao J, Mo GCH, Li S, Li G, Ma Q, Yang Q, Lal R, Zhang J, Liu Z. PMID: 32597659.
      View in: PubMed   Mentions: 8     Fields:    
    11. Sub-nanowatt microfluidic single-cell calorimetry. Nat Commun. 2020 06 12; 11(1):2982. Hong S, Dechaumphai E, Green CR, Lal R, Murphy AN, Metallo CM, Chen R. PMID: 32532969; PMCID: PMC7292832.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    12. Ion channel formation by N-terminally truncated Aβ (4-42): relevance for the pathogenesis of Alzheimer's disease. Nanomedicine. 2020 10; 29:102235. Karkisaval AG, Rostagno A, Azimov R, Ban DK, Ghiso J, Kagan BL, Lal R. PMID: 32531337; PMCID: PMC8132454.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Direct DNA Methylation Profiling with an Electric Biosensor. ACS Nano. 2020 06 23; 14(6):6743-6751. Ban DK, Liu Y, Wang Z, Ramachandran S, Sarkar N, Shi Z, Liu W, Karkisaval AG, Martinez-Loran E, Zhang F, Glinsky G, Bandaru PR, Fan C, Lal R. PMID: 32407064.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Unconventional Atomic Structure of Graphene Sheets on Solid Substrates. Small. 2019 Oct; 15(42):e1902637. Zhang J, Yang Y, Yang S, Song J, Wang Y, Liu X, Yang Q, Shen Y, Wang S, Yang H, Lü J, Li B, Fang H, Lal R, Czajkowsky DM, Hu J, Shi G, Zhang Y. PMID: 31468738.
      View in: PubMed   Mentions: 1     Fields:    
    15. Generating Cyan Fluorescence with De Novo Tripeptides: An In Vitro Mutation Study on the Role of Single Amino Acid Residues and Their Sequence. Chembiochem. 2019 09 16; 20(18):2324-2330. Guo J, Ramachandran S, Zhong R, Lal R, Zhang F. PMID: 31013385.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. MRI reporter gene MagA suppresses transferrin receptor and maps Fe2+ dependent lung cancer. Nanomedicine. 2019 10; 21:102064. Guan X, Yang B, Xie M, Ban DK, Zhao X, Lal R, Zhang F. PMID: 31326524.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Array atomic force microscopy for real-time multiparametric analysis. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):5872-5877. Yang Q, Ma Q, Herum KM, Wang C, Patel N, Lee J, Wang S, Yen TM, Wang J, Tang H, Lo YH, Head BP, Azam F, Xu S, Cauwenberghs G, McCulloch AD, John S, Liu Z, Lal R. PMID: 30850523; PMCID: PMC6442637.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. DNA Nanotweezers and Graphene Transistor Enable Label-Free Genotyping. Adv Mater. 2018 Jul 09; e1802440. Hwang MT, Wang Z, Ping J, Ban DK, Shiah ZC, Antonschmidt L, Lee J, Liu Y, Karkisaval AG, Johnson ATC, Fan C, Glinsky G, Lal R. PMID: 29984525; PMCID: PMC6326894.
      View in: PubMed   Mentions: 29     Fields:    
    19. Antioxidant activity of hydrated carboxylated nanodiamonds and its influence on water γ-radiolysis. Nanotechnology. 2018 Mar 23; 29(12):125707. Santacruz-Gomez K, Sarabia-Sainz A, Acosta-Elias M, Sarabia-Sainz M, Janetanakit W, Khosla N, Melendrez R, Montero MP, Lal R. PMID: 29337289.
      View in: PubMed   Mentions: 6     Fields:    
    20. The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Mol Med. 2018 01; 10(1):32-47. Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A. PMID: 29208638; PMCID: PMC5760857.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    21. In Situ Spatial Complementation of Aptamer-Mediated Recognition Enables Live-Cell Imaging of Native RNA Transcripts in Real Time. Angew Chem Int Ed Engl. 2018 01 22; 57(4):972-976. Wang Z, Luo Y, Xie X, Hu X, Song H, Zhao Y, Shi J, Wang L, Glinsky G, Chen N, Lal R, Fan C. PMID: 28991414.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    22. PCR-Free Colorimetric DNA Hybridization Detection Using a 3D DNA Nanostructured Reporter Probe. ACS Appl Mater Interfaces. 2017 Nov 08; 9(44):38281-38287. Yang X, Wen Y, Wang L, Zhou C, Li Q, Xu L, Li L, Shi J, Lal R, Ren S, Li J, Jia N, Liu G. PMID: 29022698.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    23. DNA Hydrogel with Aptamer-Toehold-Based Recognition, Cloaking, and Decloaking of Circulating Tumor Cells for Live Cell Analysis. Nano Lett. 2017 09 13; 17(9):5193-5198. Song P, Ye D, Zuo X, Li J, Wang J, Liu H, Hwang MT, Chao J, Su S, Wang L, Shi J, Wang L, Huang W, Lal R, Fan C. PMID: 28771008.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    24. Gold-Embedded Hollow Silica Nanogolf Balls for Imaging and Photothermal Therapy. ACS Appl Mater Interfaces. 2017 Aug 23; 9(33):27533-27543. Janetanakit W, Wang L, Santacruz-Gomez K, Landon PB, Sud PL, Patel N, Jang G, Jain M, Yepremyan A, Kazmi SA, Ban DK, Zhang F, Lal R. PMID: 28752765.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Graphite-Templated Amyloid Nanostructures Formed by a Potential Pentapeptide Inhibitor for Alzheimer's Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations. Langmuir. 2017 07 11; 33(27):6647-6656. Li N, Jang H, Yuan M, Li W, Yun X, Lee J, Du Q, Nussinov R, Hou J, Lal R, Zhang F. PMID: 28605901; PMCID: PMC7900909.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    26. Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging. Nat Commun. 2017 05 31; 8:15646. Liu M, Li Q, Liang L, Li J, Wang K, Li J, Lv M, Chen N, Song H, Lee J, Shi J, Wang L, Lal R, Fan C. PMID: 28561031; PMCID: PMC5460036.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    27. Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon-dielectric interactions. Nat Photonics. 2017; 11:352-355. Huang Q, Lee J, Arce FT, Yoon I, Angsantikul P, Liu J, Shi Y, Villanueva J, Thamphiwatana S, Ma X, Zhang L, Chen S, Lal R, Sirbuly DJ. PMID: 29576804; PMCID: PMC5863742.
      View in: PubMed   Mentions: 7  
    28. Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts. ACS Chem Neurosci. 2017 06 21; 8(6):1348-1357. Lee J, Kim YH, T Arce F, Gillman AL, Jang H, Kagan BL, Nussinov R, Yang J, Lal R. PMID: 28135799; PMCID: PMC6197823.
      View in: PubMed   Mentions: 34     Fields:    
    29. Gap controlled plasmon-dielectric coupling effects investigated with single nanoparticle-terminated atomic force microscope probes. Nanoscale. 2016 Oct 06; 8(39):17102-17107. Huang Q, Teran Arce F, Lee J, Yoon I, Villanueva J, Lal R, Sirbuly DJ. PMID: 27714046.
      View in: PubMed   Mentions: 1     Fields:    
    30. Small molecule NPT-440-1 inhibits ionic flux through Aβ1-42 pores: Implications for Alzheimer's disease therapeutics. Nanomedicine. 2016 11; 12(8):2331-2340. Gillman AL, Lee J, Ramachandran S, Capone R, Gonzalez T, Wrasidlo W, Masliah E, Lal R. PMID: 27335341; PMCID: PMC5116404.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    31. Highly specific SNP detection using 2D graphene electronics and DNA strand displacement. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):7088-93. Hwang MT, Landon PB, Lee J, Choi D, Mo AH, Glinsky G, Lal R. PMID: 27298347; PMCID: PMC4932965.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    32. Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing. Nanoscale. 2016 Jun 09; 8(23):11840-50. Mo AH, Landon PB, Gomez KS, Kang H, Lee J, Zhang C, Janetanakit W, Sant V, Lu T, Colburn DA, Akkiraju S, Dossou S, Cao Y, Lee KF, Varghese S, Glinsky G, Lal R. PMID: 27228391; PMCID: PMC6295298.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    33. Dual-Functionalized Theranostic Nanocarriers. ACS Appl Mater Interfaces. 2016 Jun 15; 8(23):14740-6. Mo AH, Zhang C, Landon PB, Janetanakit W, Hwang MT, Santacruz Gomez K, Colburn DA, Dossou SM, Lu T, Cao Y, Sant V, Sud PL, Akkiraju S, Shubayev VI, Glinsky G, Lal R. PMID: 27144808.
      View in: PubMed   Mentions: 1     Fields:    
    34. Oligomerization of the microtubule-associated protein tau is mediated by its N-terminal sequences: implications for normal and pathological tau action. J Neurochem. 2016 06; 137(6):939-54. Feinstein HE, Benbow SJ, LaPointe NE, Patel N, Ramachandran S, Do TD, Gaylord MR, Huskey NE, Dressler N, Korff M, Quon B, Cantrell KL, Bowers MT, Lal R, Feinstein SC. PMID: 26953146; PMCID: PMC4899250.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    35. Carboxylated nanodiamonds inhibit γ-irradiation damage of human red blood cells. Nanoscale. 2016 Apr 07; 8(13):7189-96. Santacruz-Gomez K, Silva-Campa E, Melendrez-Amavizca R, Teran Arce F, Mata-Haro V, Landon PB, Zhang C, Pedroza-Montero M, Lal R. PMID: 26972691.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    36. Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels. Methods Mol Biol. 2016; 1345:251-68. Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R. PMID: 26453217; PMCID: PMC7511997.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. Ion Channel Formation by Tau Protein: Implications for Alzheimer's Disease and Tauopathies. Biochemistry. 2015 Dec 22; 54(50):7320-5. Patel N, Ramachandran S, Azimov R, Kagan BL, Lal R. PMID: 26575330; PMCID: PMC4690196.
      View in: PubMed   Mentions: 24     Fields:    
    38. DNA nano-carrier for repeatable capture and release of biomolecules. Nanoscale. 2015 Nov 07; 7(41):17397-403. Hwang MT, Landon PB, Lee J, Mo A, Meckes B, Glinsky G, Lal R. PMID: 26439640.
      View in: PubMed   Mentions: 3     Fields:    
    39. Asymmetric Colloidal Janus Particle Formation Is Core-Size-Dependent. Langmuir. 2015 Aug 25; 31(33):9148-54. Landon PB, Mo AH, Printz AD, Emerson C, Zhang C, Janetanakit W, Colburn DA, Akkiraju S, Dossou S, Chong B, Glinsky G, Lal R. PMID: 26244597.
      View in: PubMed   Mentions: 2     Fields:    
    40. Synthesis of nano-bowls with a Janus template. Nanoscale. 2015 Jan 14; 7(2):771-775. Mo AH, Landon PB, Emerson CD, Zhang C, Anzenberg P, Akkiraju S, Lal R. PMID: 25431230; PMCID: PMC4353600.
      View in: PubMed   Mentions: 3     Fields:    
    41. Biocompatible Optically Transparent MEMS for Micromechanical Stimulation and Multimodal Imaging of Living Cells. Ann Biomed Eng. 2015 Aug; 43(8):1841-50. Fior R, Kwok J, Malfatti F, Sbaizero O, Lal R. PMID: 25549773; PMCID: PMC4490153.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. Atomic force microscopy shows connexin26 hemichannel clustering in purified membrane fragments. Biochemistry. 2014 Dec 02; 53(47):7407-14. Meckes B, Ambrosi C, Barnard H, Arce FT, Sosinsky GE, Lal R. PMID: 25365227; PMCID: PMC4255643.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    43. Energetically biased DNA motor containing a thermodynamically stable partial strand displacement state. Langmuir. 2014 Nov 25; 30(46):14073-8. Landon PB, Lee J, Hwang MT, Mo AH, Zhang C, Neuberger A, Meckes B, Gutierrez JJ, Glinsky G, Lal R. PMID: 25347360; PMCID: PMC4245991.
      View in: PubMed   Mentions: 4     Fields:    
    44. Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs. Chem Soc Rev. 2014 Oct 07; 43(19):6750-64. Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. PMID: 24566672; PMCID: PMC4143503.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    45. Measuring localized redox enzyme electron transfer in a live cell with conducting atomic force microscopy. Anal Chem. 2014 Aug 05; 86(15):7674-80. Alfonta L, Meckes B, Amir L, Schlesinger O, Ramachandran S, Lal R. PMID: 24979064; PMCID: PMC4215851.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    46. Designing hollow nano gold golf balls. ACS Appl Mater Interfaces. 2014 Jul 09; 6(13):9937-41. Landon PB, Mo AH, Zhang C, Emerson CD, Printz AD, Gomez AF, DeLaTorre CJ, Colburn DA, Anzenberg P, Eliceiri M, O'Connell C, Lal R. PMID: 24937196; PMCID: PMC4334244.
      View in: PubMed   Mentions: 6     Fields:    
    47. Atomic force microscopy reveals age-dependent changes in nanomechanical properties of the extracellular matrix of native human menisci: implications for joint degeneration and osteoarthritis. Nanomedicine. 2014 Nov; 10(8):1777-85. Kwok J, Grogan S, Meckes B, Arce F, Lal R, D'Lima D. PMID: 24972006; PMCID: PMC4374607.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    48. Insulated conducting cantilevered nanotips and two-chamber recording system for high resolution ion sensing AFM. Sci Rep. 2014 Mar 25; 4:4454. Meckes B, Arce FT, Connelly LS, Lal R. PMID: 24663394; PMCID: PMC3964513.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    49. Graphene nanopore support system for simultaneous high-resolution AFM imaging and conductance measurements. ACS Appl Mater Interfaces. 2014 Apr 09; 6(7):5290-6. Connelly LS, Meckes B, Larkin J, Gillman AL, Wanunu M, Lal R. PMID: 24581087; PMCID: PMC4232248.
      View in: PubMed   Mentions: 6     Fields:    
    50. Structure and permeability of ion-channels by integrated AFM and waveguide TIRF microscopy. Sci Rep. 2014 Mar 21; 4:4424. Ramachandran S, Arce FT, Patel NR, Quist AP, Cohen DA, Lal R. PMID: 24651823; PMCID: PMC3961736.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    51. An on-demand four-way junction DNAzyme nanoswitch driven by inosine-based partial strand displacement. Nanoscale. 2014; 6(3):1462-6. Mo AH, Landon PB, Meckes B, Yang MM, Glinsky GV, Lal R. PMID: 24317092.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    52. Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment. J Phys Chem B. 2013 Oct 03; 117(39):11518-29. Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. PMID: 24000923; PMCID: PMC3946471.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    53. Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. Nanomedicine. 2013 Oct; 9(7):875-84. Arce FT, Meckes B, Camp SM, Garcia JG, Dudek SM, Lal R. PMID: 23523769; PMCID: PMC3762941.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    54. Alzheimer's disease: which type of amyloid-preventing drug agents to employ? Phys Chem Chem Phys. 2013 Jun 21; 15(23):8868-77. Jang H, Connelly L, Arce FT, Ramachandran S, Lal R, Kagan BL, Nussinov R. PMID: 23450150; PMCID: PMC3663909.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    55. High performance, LED powered, waveguide based total internal reflection microscopy. Sci Rep. 2013; 3:2133. Ramachandran S, Cohen DA, Quist AP, Lal R. PMID: 23823601; PMCID: PMC3701166.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    56. Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane. J Chem Theory Comput. 2013 Jan 08; 9(1):822-833. Jang H, Connelly L, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R. PMID: 23316126; PMCID: PMC3539805.
      View in: PubMed   Mentions: 63     Fields:    
    57. Magnetic targeting of nanoparticles across the intact blood-brain barrier. J Control Release. 2012 Nov 28; 164(1):49-57. Kong SD, Lee J, Ramachandran S, Eliceiri BP, Shubayev VI, Lal R, Jin S. PMID: 23063548; PMCID: PMC4440873.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    58. Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations. Biochemistry. 2012 Apr 10; 51(14):3031-8. Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R. PMID: 22413858; PMCID: PMC7512688.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    59. All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers. J Chem Theory Comput. 2012 Mar 13; 8(3):1143-1152. Capone R, Jang H, Kotler SA, Connelly L, Teran Arce F, Ramachandran S, Kagan BL, Nussinov R, Lal R. PMID: 22423218; PMCID: PMC3302213.
      View in: PubMed   Mentions: 22     Fields:    
    60. Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology. J Phys Chem B. 2012 Feb 09; 116(5):1728-35. Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R. PMID: 22217000; PMCID: PMC4342054.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    61. Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions. Biochemistry. 2012 Jan 24; 51(3):776-85. Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R. PMID: 22242635; PMCID: PMC3265145.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    62. Antimicrobial properties of amyloid peptides. Mol Pharm. 2012 Apr 02; 9(4):708-17. Kagan BL, Jang H, Capone R, Teran Arce F, Ramachandran S, Lal R, Nussinov R. PMID: 22081976; PMCID: PMC3297685.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimals
    63. DNA zipper-based tweezers. Langmuir. 2012 Jan 10; 28(1):534-40. Landon PB, Ramachandran S, Gillman A, Gidron T, Yoon D, Lal R. PMID: 21875130.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    64. Mutant SOD1 forms ion channel: implications for ALS pathophysiology. Neurobiol Dis. 2012 Mar; 45(3):831-8. Allen MJ, Lacroix JJ, Ramachandran S, Capone R, Whitlock JL, Ghadge GD, Arnsdorf MF, Roos RP, Lal R. PMID: 21930207; PMCID: PMC3384721.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    65. Potential role of atomic force microscopy in systems biology. Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec; 3(6):702-16. Ramachandran S, Teran Arce F, Lal R. PMID: 21766465; PMCID: PMC4353599.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    66. Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation. Soft Matter. 2011 May 09; 7(11):5267-5273. Arce FT, Jang H, Ramachandran S, Landon PB, Nussinov R, Lal R. PMID: 21918653; PMCID: PMC3170770.
      View in: PubMed   Mentions: 22     Fields:    
    67. Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces. J Biol Chem. 2011 Jun 24; 286(25):22139-46. Allen MJ, Gemel J, Beyer EC, Lal R. PMID: 21543330; PMCID: PMC3121358.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    68. Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation. Biomaterials. 2011 May; 32(15):3700-11. Ayala R, Zhang C, Yang D, Hwang Y, Aung A, Shroff SS, Arce FT, Lal R, Arya G, Varghese S. PMID: 21396708.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    69. Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link. Biophys J. 2011 Apr 06; 100(7):1775-83. Jang H, Arce FT, Mustata M, Ramachandran S, Capone R, Nussinov R, Lal R. PMID: 21463591; PMCID: PMC3072611.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    70. Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. Nano Lett. 2010 Dec 08; 10(12):5088-92. Kong SD, Zhang W, Lee JH, Brammer K, Lal R, Karin M, Jin S. PMID: 21038917.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    71. β-Barrel topology of Alzheimer's β-amyloid ion channels. J Mol Biol. 2010 Dec 17; 404(5):917-34. Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R. PMID: 20970427; PMCID: PMC7291702.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    72. Multidimensional atomic force microscopy: a versatile novel technology for nanopharmacology research. AAPS J. 2010 Dec; 12(4):716-28. Lal R, Ramachandran S, Arnsdorf MF. PMID: 20957528; PMCID: PMC2976997.
      View in: PubMed   Mentions: 10     Fields:    
    73. Scope of atomic force microscopy in the advancement of nanomedicine. Indian J Exp Biol. 2010 Oct; 48(10):1020-36. Ramachandran S, Lal R. PMID: 21299045.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    74. Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function. Mol Biol Cell. 2010 Nov 15; 21(22):4042-56. Dudek SM, Chiang ET, Camp SM, Guo Y, Zhao J, Brown ME, Singleton PA, Wang L, Desai A, Arce FT, Lal R, Van Eyk JE, Imam SZ, Garcia JG. PMID: 20861316; PMCID: PMC2982111.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    75. Structural convergence among diverse, toxic beta-sheet ion channels. J Phys Chem B. 2010 Jul 29; 114(29):9445-51. Jang H, Teran Arce F, Ramachandran S, Capone R, Lal R, Nussinov R. PMID: 20608696; PMCID: PMC2908347.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    76. Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies. Biophys J. 2010 Jun 02; 98(11):2644-52. Capone R, Mustata M, Jang H, Arce FT, Nussinov R, Lal R. PMID: 20513409; PMCID: PMC2877344.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    77. Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6538-43. Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R. PMID: 20308552; PMCID: PMC2851998.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    78. Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels. Biophys J. 2009 Dec 02; 97(11):3029-37. Jang H, Arce FT, Capone R, Ramachandran S, Lal R, Nussinov R. PMID: 19948133; PMCID: PMC2784570.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    79. K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis. J Am Chem Soc. 2009 Oct 21; 131(41):14938-45. Mustata M, Capone R, Jang H, Arce FT, Ramachandran S, Lal R, Nussinov R. PMID: 19824733; PMCID: PMC2782653.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    80. Multidimensional atomic force microscopy for drug discovery: a versatile tool for defining targets, designing therapeutics and monitoring their efficacy. Life Sci. 2010 Apr 10; 86(15-16):545-62. Lal R, Arnsdorf MF. PMID: 20359578.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    81. Nanoscale structural and mechanical properties of nontypeable Haemophilus influenzae biofilms. J Bacteriol. 2009 Apr; 191(8):2512-20. Arce FT, Carlson R, Monds J, Veeh R, Hu FZ, Stewart PS, Lal R, Ehrlich GD, Avci R. PMID: 19218382; PMCID: PMC2668387.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    82. Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: atomic force microscopy force mapping of pulmonary endothelial monolayer. Nanomedicine. 2009 Mar; 5(1):30-41. Birukova AA, Arce FT, Moldobaeva N, Dudek SM, Garcia JG, Lal R, Birukov KG. PMID: 18824415; PMCID: PMC2820397.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    83. Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels. Biophys J. 2008 Nov 15; 95(10):4631-42. Jang H, Ma B, Lal R, Nussinov R. PMID: 18708452; PMCID: PMC2576390.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    84. Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. Biophys J. 2008 Jul; 95(2):886-94. Arce FT, Whitlock JL, Birukova AA, Birukov KG, Arnsdorf MF, Lal R, Garcia JG, Dudek SM. PMID: 18408039; PMCID: PMC2440433.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    85. New structures help the modeling of toxic amyloidbeta ion channels. Trends Biochem Sci. 2008 Feb; 33(2):91-100. Jang H, Zheng J, Lal R, Nussinov R. PMID: 18182298.
      View in: PubMed   Mentions: 67     Fields:    Translation:Cells
    86. A novel role for connexin hemichannel in oxidative stress and smoking-induced cell injury. PLoS One. 2007 Aug 08; 2(8):e712. Ramachandran S, Xie LH, John SA, Subramaniam S, Lal R. PMID: 17684558; PMCID: PMC1933596.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    87. Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm. Biochim Biophys Acta. 2007 Aug; 1768(8):1966-75. Lal R, Lin H, Quist AP. PMID: 17553456; PMCID: PMC2692960.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    88. AFM nanoindentations of diatom biosilica surfaces. Langmuir. 2007 Apr 24; 23(9):5014-21. Losic D, Short K, Mitchell JG, Lal R, Voelcker NH. PMID: 17397194.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    89. Atomic force microscopy imaging and electrical recording of lipid bilayers supported over microfabricated silicon chip nanopores: lab-on-a-chip system for lipid membranes and ion channels. Langmuir. 2007 Jan 30; 23(3):1375-80. Quist AP, Chand A, Ramachandran S, Daraio C, Jin S, Lal R. PMID: 17241061.
      View in: PubMed   Mentions: 9     Fields:    
    90. Cisplatin nanoliposomes for cancer therapy: AFM and fluorescence imaging of cisplatin encapsulation, stability, cellular uptake, and toxicity. Langmuir. 2006 Sep 12; 22(19):8156-62. Ramachandran S, Quist AP, Kumar S, Lal R. PMID: 16952256.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    91. Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels. Lab Chip. 2006 Nov; 6(11):1450-4. Quist A, Chand A, Ramachandran S, Cohen D, Lal R. PMID: 17066169.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    92. Alzheimer Research Forum Live Discussion: Now you see them, now you don't: The amyloid channel hypothesis. J Alzheimers Dis. 2006 Jul; 9(2):219-24. Fagan T, Kagan B, Corbin D, Hwang W, Glabe C, Nault L, Lal R, Teplow D, Albensi B, Sokolov Y. PMID: 16873968.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    93. Nanomechanics of hemichannel conformations: connexin flexibility underlying channel opening and closing. J Biol Chem. 2006 Aug 11; 281(32):23207-17. Liu F, Arce FT, Ramachandran S, Lal R. PMID: 16769719.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    94. Amyloid ion channels: a common structural link for protein-misfolding disease. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10427-32. Quist A, Doudevski I, Lin H, Azimova R, Ng D, Frangione B, Kagan B, Ghiso J, Lal R. PMID: 16020533; PMCID: PMC1180768.
      View in: PubMed   Mentions: 387     Fields:    Translation:Cells
    95. Calcium-dependent open/closed conformations and interfacial energy maps of reconstituted hemichannels. J Biol Chem. 2005 Mar 18; 280(11):10646-54. Thimm J, Mechler A, Lin H, Rhee S, Lal R. PMID: 15615707.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    96. Immunologic cross-reactivity between structural proteins of human T-cell lymphotropic virus type I and the blood stage of Plasmodium falciparum. Clin Diagn Lab Immunol. 1994 Jan; 1(1):5-10. Lal RB, Rudolph D, Alpers MP, Sulzer AJ, Shi YP, Lal AA. PMID: 7496921; PMCID: PMC368187.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
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