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Ratneshwar Lal

Title(s)Professor, Mechanical and Aerospace Engineering
SchoolVc-academic Affairs
Address9500 Gilman Drive #0412
La Jolla CA 92093
Phone8/8-22--0384
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    Collapse Research 
    Collapse Research Activities and Funding
    Designing array-AFM to study cellular interactions mediating transmission and progression of AD pathophysiology in brain
    NIH/NIA R56AG058069Sep 30, 2018 - May 31, 2020
    Role: Principal Investigator
    Designing an Integrated Nanoscale System for Ion Channel Structure-Function Study
    NIH/NIDA R01DA025296Jul 15, 2008 - Dec 31, 2009
    Role: Principal Investigator
    Amyloid ion channels to design therapeutics for neurodegenerative diseases
    NIH/NIA R01AG028709Sep 15, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Cytoskeletal Regulation of Lung Endothelial Pathobiology
    NIH P01HL058064Feb 1, 1998 - Jan 31, 2014
    Role: Co-Investigator
    Structure, Activity &Physiological Role of Hemichannels
    NIH/NIDA R01DA024871Sep 1, 1997 - Feb 28, 2014
    Role: Principal Investigator
    Structure, Activity &Physiological Role of Hemichannels
    NIH/NIGMS R01GM056290Sep 1, 1997 - Sep 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metamaterial-Assisted Photobleaching Microscopy with Nanometer Scale Axial Resolution. Nano Lett. 2020 Aug 12; 20(8):6038-6044. Lee YU, Zhao J, Mo GCH, Li S, Li G, Ma Q, Yang Q, Lal R, Zhang J, Liu Z. PMID: 32597659.
      View in: PubMed   Mentions:    Fields:    
    2. Sub-nanowatt microfluidic single-cell calorimetry. Nat Commun. 2020 06 12; 11(1):2982. Hong S, Dechaumphai E, Green CR, Lal R, Murphy AN, Metallo CM, Chen R. PMID: 32532969.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Ion channel formation by N-terminally truncated Aß (4-42): relevance for the pathogenesis of Alzheimer's disease. Nanomedicine. 2020 Jun 10; 29:102235. Karkisaval AG, Rostagno A, Azimov R, Ban DK, Ghiso J, Kagan BL, Lal R. PMID: 32531337.
      View in: PubMed   Mentions:    Fields:    
    4. Direct DNA Methylation Profiling with an Electric Biosensor. ACS Nano. 2020 Jun 23; 14(6):6743-6751. Ban DK, Liu Y, Wang Z, Ramachandran S, Sarkar N, Shi Z, Liu W, Karkisaval AG, Martinez-Loran E, Zhang F, Glinsky G, Bandaru PR, Fan C, Lal R. PMID: 32407064.
      View in: PubMed   Mentions:    Fields:    
    5. Array atomic force microscopy for real-time multiparametric analysis. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):5872-5877. Yang Q, Ma Q, Herum KM, Wang C, Patel N, Lee J, Wang S, Yen TM, Wang J, Tang H, Lo YH, Head BP, Azam F, Xu S, Cauwenberghs G, McCulloch AD, John S, Liu Z, Lal R. PMID: 30850523.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. DNA Nanotweezers and Graphene Transistor Enable Label-Free Genotyping. Adv Mater. 2018 Jul 09; e1802440. Hwang MT, Wang Z, Ping J, Ban DK, Shiah ZC, Antonschmidt L, Lee J, Liu Y, Karkisaval AG, Johnson ATC, Fan C, Glinsky G, Lal R. PMID: 29984525.
      View in: PubMed   Mentions: 1     Fields:    
    7. Antioxidant activity of hydrated carboxylated nanodiamonds and its influence on water ?-radiolysis. Nanotechnology. 2018 Mar 23; 29(12):125707. Santacruz-Gomez K, Sarabia-Sainz A, Acosta-Elias M, Sarabia-Sainz M, Janetanakit W, Khosla N, Melendrez R, Montero MP, Lal R. PMID: 29337289.
      View in: PubMed   Mentions: 1     Fields:    
    8. Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon-dielectric interactions. Nat Photonics. 2017; 11:352-355. Huang Q, Lee J, Arce FT, Yoon I, Angsantikul P, Liu J, Shi Y, Villanueva J, Thamphiwatana S, Ma X, Zhang L, Chen S, Lal R, Sirbuly DJ. PMID: 29576804.
      View in: PubMed   Mentions:
    9. Gap controlled plasmon-dielectric coupling effects investigated with single nanoparticle-terminated atomic force microscope probes. Nanoscale. 2016 Oct 06; 8(39):17102-17107. Huang Q, Teran Arce F, Lee J, Yoon I, Villanueva J, Lal R, Sirbuly DJ. PMID: 27714046.
      View in: PubMed   Mentions: 1     Fields:    
    10. Small molecule NPT-440-1 inhibits ionic flux through Aß1-42 pores: Implications for Alzheimer's disease therapeutics. Nanomedicine. 2016 11; 12(8):2331-2340. Gillman AL, Lee J, Ramachandran S, Capone R, Gonzalez T, Wrasidlo W, Masliah E, Lal R. PMID: 27335341.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Highly specific SNP detection using 2D graphene electronics and DNA strand displacement. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):7088-93. Hwang MT, Landon PB, Lee J, Choi D, Mo AH, Glinsky G, Lal R. PMID: 27298347.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing. Nanoscale. 2016 Jun 09; 8(23):11840-50. Mo AH, Landon PB, Gomez KS, Kang H, Lee J, Zhang C, Janetanakit W, Sant V, Lu T, Colburn DA, Akkiraju S, Dossou S, Cao Y, Lee KF, Varghese S, Glinsky G, Lal R. PMID: 27228391.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Carboxylated nanodiamonds inhibit ?-irradiation damage of human red blood cells. Nanoscale. 2016 Apr 07; 8(13):7189-96. Santacruz-Gomez K, Silva-Campa E, Melendrez-Amavizca R, Teran Arce F, Mata-Haro V, Landon PB, Zhang C, Pedroza-Montero M, Lal R. PMID: 26972691.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Ion Channel Formation by Tau Protein: Implications for Alzheimer's Disease and Tauopathies. Biochemistry. 2015 Dec 22; 54(50):7320-5. Patel N, Ramachandran S, Azimov R, Kagan BL, Lal R. PMID: 26575330.
      View in: PubMed   Mentions: 7     Fields:    
    15. DNA nano-carrier for repeatable capture and release of biomolecules. Nanoscale. 2015 Nov 07; 7(41):17397-403. Hwang MT, Landon PB, Lee J, Mo A, Meckes B, Glinsky G, Lal R. PMID: 26439640.
      View in: PubMed   Mentions: 2     Fields:    
    16. Asymmetric Colloidal Janus Particle Formation Is Core-Size-Dependent. Langmuir. 2015 Aug 25; 31(33):9148-54. Landon PB, Mo AH, Printz AD, Emerson C, Zhang C, Janetanakit W, Colburn DA, Akkiraju S, Dossou S, Chong B, Glinsky G, Lal R. PMID: 26244597.
      View in: PubMed   Mentions:    Fields:    
    17. Synthesis of nano-bowls with a Janus template. Nanoscale. 2015 Jan 14; 7(2):771-775. Mo AH, Landon PB, Emerson CD, Zhang C, Anzenberg P, Akkiraju S, Lal R. PMID: 25431230.
      View in: PubMed   Mentions:    Fields:    
    18. Biocompatible Optically Transparent MEMS for Micromechanical Stimulation and Multimodal Imaging of Living Cells. Ann Biomed Eng. 2015 Aug; 43(8):1841-50. Fior R, Kwok J, Malfatti F, Sbaizero O, Lal R. PMID: 25549773.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Atomic force microscopy shows connexin26 hemichannel clustering in purified membrane fragments. Biochemistry. 2014 Dec 02; 53(47):7407-14. Meckes B, Ambrosi C, Barnard H, Arce FT, Sosinsky GE, Lal R. PMID: 25365227.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    20. Energetically biased DNA motor containing a thermodynamically stable partial strand displacement state. Langmuir. 2014 Nov 25; 30(46):14073-8. Landon PB, Lee J, Hwang MT, Mo AH, Zhang C, Neuberger A, Meckes B, Gutierrez JJ, Glinsky G, Lal R. PMID: 25347360.
      View in: PubMed   Mentions: 3     Fields:    
    21. Designing hollow nano gold golf balls. ACS Appl Mater Interfaces. 2014 Jul 09; 6(13):9937-41. Landon PB, Mo AH, Zhang C, Emerson CD, Printz AD, Gomez AF, DeLaTorre CJ, Colburn DA, Anzenberg P, Eliceiri M, O'Connell C, Lal R. PMID: 24937196.
      View in: PubMed   Mentions: 1     Fields:    
    22. Atomic force microscopy reveals age-dependent changes in nanomechanical properties of the extracellular matrix of native human menisci: implications for joint degeneration and osteoarthritis. Nanomedicine. 2014 Nov; 10(8):1777-85. Kwok J, Grogan S, Meckes B, Arce F, Lal R, D'Lima D. PMID: 24972006.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Insulated conducting cantilevered nanotips and two-chamber recording system for high resolution ion sensing AFM. Sci Rep. 2014 Mar 25; 4:4454. Meckes B, Arce FT, Connelly LS, Lal R. PMID: 24663394.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    24. Graphene nanopore support system for simultaneous high-resolution AFM imaging and conductance measurements. ACS Appl Mater Interfaces. 2014 Apr 09; 6(7):5290-6. Connelly LS, Meckes B, Larkin J, Gillman AL, Wanunu M, Lal R. PMID: 24581087.
      View in: PubMed   Mentions: 5     Fields:    
    25. Structure and permeability of ion-channels by integrated AFM and waveguide TIRF microscopy. Sci Rep. 2014 Mar 21; 4:4424. Ramachandran S, Arce FT, Patel NR, Quist AP, Cohen DA, Lal R. PMID: 24651823.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    26. An on-demand four-way junction DNAzyme nanoswitch driven by inosine-based partial strand displacement. Nanoscale. 2014; 6(3):1462-6. Mo AH, Landon PB, Meckes B, Yang MM, Glinsky GV, Lal R. PMID: 24317092.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    27. Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. Nanomedicine. 2013 Oct; 9(7):875-84. Arce FT, Meckes B, Camp SM, Garcia JG, Dudek SM, Lal R. PMID: 23523769.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. High performance, LED powered, waveguide based total internal reflection microscopy. Sci Rep. 2013; 3:2133. Ramachandran S, Cohen DA, Quist AP, Lal R. PMID: 23823601.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    29. Effects of point substitutions on the structure of toxic Alzheimer's ß-amyloid channels: atomic force microscopy and molecular dynamics simulations. Biochemistry. 2012 Apr 10; 51(14):3031-8. Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R. PMID: 22413858.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    30. Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's ß-amyloid peptide: relevance to the ion channel mechanism of AD pathology. J Phys Chem B. 2012 Feb 09; 116(5):1728-35. Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R. PMID: 22217000.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    31. Probing structural features of Alzheimer's amyloid-ß pores in bilayers using site-specific amino acid substitutions. Biochemistry. 2012 Jan 24; 51(3):776-85. Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R. PMID: 22242635.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    32. DNA zipper-based tweezers. Langmuir. 2012 Jan 10; 28(1):534-40. Landon PB, Ramachandran S, Gillman A, Gidron T, Yoon D, Lal R. PMID: 21875130.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    33. Potential role of atomic force microscopy in systems biology. Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec; 3(6):702-16. Ramachandran S, Teran Arce F, Lal R. PMID: 21766465.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Polymorphism of amyloid ß peptide in different environments: implications for membrane insertion and pore formation. Soft Matter. 2011 May 09; 7(11):5267-5273. Arce FT, Jang H, Ramachandran S, Landon PB, Nussinov R, Lal R. PMID: 21918653.
      View in: PubMed   Mentions: 15     Fields:    
    35. Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation. Biomaterials. 2011 May; 32(15):3700-11. Ayala R, Zhang C, Yang D, Hwang Y, Aung A, Shroff SS, Arce FT, Lal R, Arya G, Varghese S. PMID: 21396708.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    36. Multidimensional atomic force microscopy: a versatile novel technology for nanopharmacology research. AAPS J. 2010 Dec; 12(4):716-28. Lal R, Ramachandran S, Arnsdorf MF. PMID: 20957528.
      View in: PubMed   Mentions: 6     Fields:    
    37. Scope of atomic force microscopy in the advancement of nanomedicine. Indian J Exp Biol. 2010 Oct; 48(10):1020-36. Ramachandran S, Lal R. PMID: 21299045.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
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