Reuben Shaw

Title(s)Adjunct Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Understanding the role of autophagy-regulated cell death in the escape from replicative crisis
    NIH R01CA234047Dec 1, 2019 - Nov 30, 2024
    Role: Co-Principal Investigator
    Decoding And Targeting The LKB1-AMPK Signaling Pathway In Cancer
    NIH R35CA220538Aug 1, 2017 - Jul 31, 2024
    Role: Principal Investigator
    Protein Kinases and Protein Phosphorylation
    NIH R13CA180697Jul 10, 2013 - Jul 9, 2014
    Role: Principal Investigator
    AMPK and AMPK-related kinases in lung cancer development and treatment
    NIH R01CA172229Jan 16, 2013 - Dec 31, 2017
    Role: Principal Investigator
    LKB1- AMPK pathway regulation of glucose metabolism and metformin action in liver
    NIH R01DK080425Sep 30, 2007 - Jun 30, 2017
    Role: Principal Investigator
    NIH F32CA088452Sep 1, 2000
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA014195Dec 1, 1977 - Jan 31, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth. Cancer Discov. 2024 Jan 25; OF1-OF22. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteíza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. PMID: 38270272.
      View in: PubMed   Mentions:    Fields:    
    2. EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. Cancer Discov. 2024 Jan 19. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteiza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. PMID: 38241033.
      View in: PubMed   Mentions:    Fields:    
    3. Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science. 2023 06 30; 380(6652):1372-1380. Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM, Szabo G, Sicinski P, Miao J, Lee YR, Pan L, Shaw RJ, Yuan J, Wei W. PMID: 37384704; PMCID: PMC10617018.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress. Sci Adv. 2023 05 03; 9(18):eadf0138. Kuna RS, Kumar A, Wessendorf-Rodriguez KA, Galvez H, Green CR, McGregor GH, Cordes T, Shaw RJ, Svensson RU, Metallo CM. PMID: 37134162; PMCID: PMC10156121.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    5. Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Science. 2023 04 21; 380(6642):eabj5559. Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. PMID: 37079666; PMCID: PMC10794112.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    6. LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Cancer Discov. 2023 04 03; 13(4):1002-1025. Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. PMID: 36715544; PMCID: PMC10068449.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    7. HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancer. Sci Adv. 2023 03 15; 9(11):eadd3243. Eichner LJ, Curtis SD, Brun SN, McGuire CK, Gushterova I, Baumgart JT, Trefts E, Ross DS, Rymoff TJ, Shaw RJ. PMID: 36930718; PMCID: PMC10022903.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    8. Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer. Sci Adv. 2022 09 30; 8(39):eabo1123. Pariollaud M, Ibrahim LH, Irizarry E, Mello RM, Chan AB, Altman BJ, Shaw RJ, Bollong MJ, Wiseman RL, Lamia KA. PMID: 36170373; PMCID: PMC9519049.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    9. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. Nat Commun. 2022 07 05; 13(1):3856. Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J. PMID: 35790710; PMCID: PMC9256702.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    10. Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in PolgD257A mice. Sci Adv. 2021 Oct 15; 7(42):eabj4077. Lim EW, Handzlik MK, Trefts E, Gengatharan JM, Pondevida CM, Shaw RJ, Metallo CM. PMID: 34652935; PMCID: PMC8519573.
      View in: PubMed   Mentions: 3     Fields:    
    11. AMPK: restoring metabolic homeostasis over space and time. Mol Cell. 2021 09 16; 81(18):3677-3690. Trefts E, Shaw RJ. PMID: 34547233; PMCID: PMC8549486.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    12. AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Sci Adv. 2021 04; 7(15). Hung CM, Lombardo PS, Malik N, Brun SN, Hellberg K, Van Nostrand JL, Garcia D, Baumgart J, Diffenderfer K, Asara JM, Shaw RJ. PMID: 33827825; PMCID: PMC8026119.
      View in: PubMed   Mentions: 41     Fields:    
    13. Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. Oncogene. 2021 03; 40(9):1690-1705. Lin C, Blessing AM, Pulliam TL, Shi Y, Wilkenfeld SR, Han JJ, Murray MM, Pham AH, Duong K, Brun SN, Shaw RJ, Ittmann MM, Frigo DE. PMID: 33531625; PMCID: PMC7935762.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    14. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020 12 10; 63(23):14609-14625. Ren H, Bakas NA, Vamos M, Chaikuad A, Limpert AS, Wimer CD, Brun SN, Lambert LJ, Tautz L, Celeridad M, Sheffler DJ, Knapp S, Shaw RJ, Cosford NDP. PMID: 33200929; PMCID: PMC8064294.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    15. AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation. Genes Dev. 2020 10 01; 34(19-20):1330-1344. Van Nostrand JL, Hellberg K, Luo EC, Van Nostrand EL, Dayn A, Yu J, Shokhirev MN, Dayn Y, Yeo GW, Shaw RJ. PMID: 32912901; PMCID: PMC7528705.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    16. PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metab. 2020 08 04; 32(2):215-228.e7. Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC. PMID: 32663458; PMCID: PMC8065255.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    17. Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. Cell Rep. 2019 12 03; 29(10):3331-3348.e7. Stein BD, Calzolari D, Hellberg K, Hu YS, He L, Hung CM, Toyama EQ, Ross DS, Lillemeier BF, Cantley LC, Yates JR, Shaw RJ. PMID: 31801093; PMCID: PMC6980792.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    18. Comparison of CRISPR Genomic Tagging for Affinity Purification and Endogenous Immunoprecipitation Coupled with Quantitative Mass Spectrometry To Identify the Dynamic AMPKα2 Interactome. J Proteome Res. 2019 10 04; 18(10):3703-3714. Stein BD, Herzig S, Martínez-Bartolomé S, Lavallée-Adam M, Shaw RJ, Yates JR. PMID: 31398040; PMCID: PMC7512655.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC. Cancer Discov. 2019 11; 9(11):1606-1627. Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ. PMID: 31350328; PMCID: PMC6825547.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    20. The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer. Sci Adv. 2019 07; 5(7):eaaw6455. Rodón L, Svensson RU, Wiater E, Chun MGH, Tsai WW, Eichner LJ, Shaw RJ, Montminy M. PMID: 31355336; PMCID: PMC6656544.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    21. Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway. Protein Cell. 2019 07; 10(7):485-495. Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Sancho-Martinez I, Takahashi Y, Hatanaka F, Wu J, Ocampo A, Reddy P, Wu MZ, Gerken L, Shaw RJ, Rodriguez Esteban C, Benner C, Nakagawa H, Guillen Garcia P, Nuñez Delicado E, Castells A, Campistol JM, Liu GH, Izpisua Belmonte JC. PMID: 31041783; PMCID: PMC6588654.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019 01; 565(7741):659-663. Nassour J, Radford R, Correia A, Fusté JM, Schoell B, Jauch A, Shaw RJ, Karlseder J. PMID: 30675059; PMCID: PMC6557118.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansCells
    23. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Rep. 2019 01 02; 26(1):192-208.e6. Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. PMID: 30605676; PMCID: PMC6344045.
      View in: PubMed   Mentions: 108     Fields:    Translation:Animals
    24. Autophagy in Cancer: Regulation by Small Molecules. Trends Pharmacol Sci. 2018 12; 39(12):1021-1032. Limpert AS, Lambert LJ, Bakas NA, Bata N, Brun SN, Shaw RJ, Cosford NDP. PMID: 30454769; PMCID: PMC6349222.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    25. Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models. Cell Metab. 2019 02 05; 29(2):285-302.e7. Eichner LJ, Brun SN, Herzig S, Young NP, Curtis SD, Shackelford DB, Shokhirev MN, Leblanc M, Vera LI, Hutchins A, Ross DS, Shaw RJ, Svensson RU. PMID: 30415923; PMCID: PMC6365213.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    26. AMPK Regulates the Epigenome through Phosphorylation of TET2. Cell Metab. 2018 10 02; 28(4):534-536. Fiedler EC, Shaw RJ. PMID: 30282044.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    27. Inflamed T cells and stroma drive gut tumors. Science. 2018 07 27; 361(6400):332-333. Hollstein PE, Shaw RJ. PMID: 30049865.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    28. GNAS shifts metabolism in pancreatic cancer. Nat Cell Biol. 2018 Jul; 20(7):740-741. Hollstein PE, Shaw RJ. PMID: 29941928.
      View in: PubMed   Mentions: 10     Fields:    
    29. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018 02; 19(2):121-135. Herzig S, Shaw RJ. PMID: 28974774; PMCID: PMC5780224.
      View in: PubMed   Mentions: 1248     Fields:    Translation:HumansAnimalsCells
    30. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19; 171(3):696-709.e23. Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. PMID: 28965760; PMCID: PMC5728659.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    31. AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. Mol Cell. 2017 Jun 15; 66(6):789-800. Garcia D, Shaw RJ. PMID: 28622524; PMCID: PMC5553560.
      View in: PubMed   Mentions: 653     Fields:    Translation:HumansAnimalsCells
    32. Editorial overview: Cell regulation: 1000 Flavors including chocolate and chili peppers. Curr Opin Cell Biol. 2017 04; 45:iv-vi. Ruggero D, Shaw RJ. PMID: 28641761.
      View in: PubMed   Mentions:    Fields:    
    33. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. Cell Metab. 2017 02 07; 25(2):463-471. Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. PMID: 28089566; PMCID: PMC5299044.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    34. Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer. Cold Spring Harb Symp Quant Biol. 2016; 81:93-103. Svensson RU, Shaw RJ. PMID: 28062532.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    35. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng. 2017 09; 43(Pt B):208-217. Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. PMID: 28034771; PMCID: PMC5484750.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    36. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 10; 22(10):1108-1119. Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ. PMID: 27643638; PMCID: PMC5053891.
      View in: PubMed   Mentions: 226     Fields:    Translation:HumansAnimalsCells
    37. Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity. Cell. 2016 May 19; 165(5):1209-1223. Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Tronnes SU, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A. PMID: 27133168; PMCID: PMC4889222.
      View in: PubMed   Mentions: 178     Fields:    Translation:AnimalsCells
    38. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016 Mar 01; 30(5):535-52. Young NP, Kamireddy A, Van Nostrand JL, Eichner LJ, Shokhirev MN, Dayn Y, Shaw RJ. PMID: 26944679; PMCID: PMC4782048.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    39. Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 2016 Jan 15; 351(6270):275-281. Toyama EQ, Herzig S, Courchet J, Lewis TL, Losón OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ. PMID: 26816379; PMCID: PMC4852862.
      View in: PubMed   Mentions: 481     Fields:    Translation:HumansCells
    40. AMPK Keeps Tumor Cells from Starving to Death. Cell Stem Cell. 2015 Nov 05; 17(5):503-4. Shaw RJ. PMID: 26544110.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    41. Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice. J Proteome Res. 2015 Nov 06; 14(11):4815-22. McClatchy DB, Ma Y, Liu C, Stein BD, Martínez-Bartolomé S, Vasquez D, Hellberg K, Shaw RJ, Yates JR. PMID: 26445171; PMCID: PMC4642245.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    42. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metab. 2015 Nov 03; 22(5):907-21. Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A. PMID: 26456332; PMCID: PMC4635044.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    43. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol Cell. 2015 Jul 16; 59(2):285-97. Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ. PMID: 26118643; PMCID: PMC4530630.
      View in: PubMed   Mentions: 349     Fields:    Translation:HumansAnimalsCells
    44. Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK. Curr Biol. 2015 May 18; 25(10):R418-20. Shaw RJ. PMID: 25989082.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    45. Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol. 2015 Apr; 17(4):532. Xia Y, Yeddula N, Leblanc M, Ke E, Zhang Y, Oldfield E, Shaw RJ, Verma IM. PMID: 25812528.
      View in: PubMed   Mentions: 3     Fields:    
    46. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Mol Cell. 2014 Aug 07; 55(3):436-50. Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. PMID: 25042806; PMCID: PMC4151130.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    47. Transcriptional coregulators: fine-tuning metabolism. Cell Metab. 2014 Jul 01; 20(1):26-40. Mouchiroud L, Eichner LJ, Shaw RJ, Auwerx J. PMID: 24794975; PMCID: PMC4079747.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    48. Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2554-9. Faubert B, Vincent EE, Griss T, Samborska B, Izreig S, Svensson RU, Mamer OA, Avizonis D, Shackelford DB, Shaw RJ, Jones RG. PMID: 24550282; PMCID: PMC3932920.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    49. Metformin trims fats to restore insulin sensitivity. Nat Med. 2013 Dec; 19(12):1570-2. Shaw RJ. PMID: 24309653.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    50. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab. 2013 Nov 05; 18(5):726-39. Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, Campos C, Zhu S, Yang H, Yong WH, Cloughesy TF, Mellinghoff IK, Cavenee WK, Shaw RJ, Mischel PS. PMID: 24140020; PMCID: PMC3840163.
      View in: PubMed   Mentions: 238     Fields:    Translation:HumansAnimalsCells
    51. Cancer metabolism in breadth and depth. Nat Biotechnol. 2013 Jun; 31(6):505-7. Chun MG, Shaw RJ. PMID: 23752435.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    52. Cell biology. GATORs take a bite out of mTOR. Science. 2013 May 31; 340(6136):1056-7. Shaw RJ. PMID: 23723225.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    53. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov. 2013 Aug; 3(8):870-9. Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK. PMID: 23715154; PMCID: PMC3753578.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    54. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell. 2013 Feb 11; 23(2):143-58. Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. PMID: 23352126; PMCID: PMC3579627.
      View in: PubMed   Mentions: 322     Fields:    Translation:HumansAnimalsCells
    55. Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab. 2013 Jan; 24(1):48-57. Mihaylova MM, Shaw RJ. PMID: 23062770; PMCID: PMC3532556.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    56. Cancer metabolism: Tumour friend or foe. Nature. 2012 May 31; 485(7400):590-1. Svensson RU, Shaw RJ. PMID: 22660317.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    57. Cell biology. Ancient sensor for ancient drug. Science. 2012 May 18; 336(6083):813-4. Shaw RJ, Cantley LC. PMID: 22605741.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    58. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, et al. PMID: 22966490; PMCID: PMC3404883.
      View in: PubMed   Mentions: 1815     Fields:    Translation:HumansAnimals
    59. Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol. 2012 Feb 12; 14(3):257-65. Xia Y, Yeddula N, Leblanc M, Ke E, Zhang Y, Oldfield E, Shaw RJ, Verma IM. PMID: 22327365; PMCID: PMC3290728.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    60. Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. F1000 Biol Rep. 2012; 4:2. Shaw RJ, Cantley LC. PMID: 22242042; PMCID: PMC3255319.
      View in: PubMed   Mentions: 15  
    61. A decade of molecular cell biology: achievements and challenges. Nat Rev Mol Cell Biol. 2011 Sep 23; 12(10):669-74. Akhtar A, Fuchs E, Mitchison T, Shaw RJ, St Johnston D, Strasser A, Taylor S, Walczak C, Zerial M. PMID: 21941276; PMCID: PMC3282063.
      View in: PubMed   Mentions: 4     Fields:    
    62. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011 Sep 02; 13(9):1016-23. Mihaylova MM, Shaw RJ. PMID: 21892142; PMCID: PMC3249400.
      View in: PubMed   Mentions: 1349     Fields:    Translation:HumansAnimalsCells
    63. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy. 2011 Jun; 7(6):643-4. Egan D, Kim J, Shaw RJ, Guan KL. PMID: 21460621; PMCID: PMC3359466.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansAnimalsCells
    64. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 2011 May 13; 145(4):607-21. Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ. PMID: 21565617; PMCID: PMC3117637.
      View in: PubMed   Mentions: 302     Fields:    Translation:AnimalsCells
    65. A hormone-dependent module regulating energy balance. Cell. 2011 May 13; 145(4):596-606. Wang B, Moya N, Niessen S, Hoover H, Mihaylova MM, Shaw RJ, Yates JR, Fischer WH, Thomas JB, Montminy M. PMID: 21565616; PMCID: PMC3129781.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    66. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 06; 13(4):376-388. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. PMID: 21459323; PMCID: PMC3086578.
      View in: PubMed   Mentions: 686     Fields:    Translation:HumansAnimalsCells
    67. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 2011 Feb 17; 470(7334):404-8. Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A. PMID: 21331044; PMCID: PMC3098900.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    68. Genomics: Drugs, diabetes and cancer. Nature. 2011 Feb 17; 470(7334):338-9. Birnbaum MJ, Shaw RJ. PMID: 21331030; PMCID: PMC4237313.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    69. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011 Jan 28; 331(6016):456-61. Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. PMID: 21205641; PMCID: PMC3030664.
      View in: PubMed   Mentions: 1256     Fields:    Translation:HumansAnimalsCells
    70. LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. J Biol Chem. 2010 Jul 16; 285(29):22291-8. Ohashi K, Ouchi N, Higuchi A, Shaw RJ, Walsh K. PMID: 20489196; PMCID: PMC2903404.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    71. Metabolism and cancer in La Jolla. Cancer Res. 2010 May 15; 70(10):3864-9. Shaw RJ, Evans RM, Simon MC. PMID: 20442287; PMCID: PMC2873170.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    72. Metabolism and cancer mix in Madrid. EMBO Rep. 2010 Apr; 11(4):249-51. Shaw RJ. PMID: 20300115; PMCID: PMC2854603.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    73. Raptor is phosphorylated by cdc2 during mitosis. PLoS One. 2010 Feb 12; 5(2):e9197. Gwinn DM, Asara JM, Shaw RJ. PMID: 20169205; PMCID: PMC2820552.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    74. Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J Biol Chem. 2009 Dec 18; 284(51):35839-49. Ikeda Y, Sato K, Pimentel DR, Sam F, Shaw RJ, Dyck JR, Walsh K. PMID: 19828446; PMCID: PMC2791013.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    75. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science. 2009 Oct 16; 326(5951):437-40. Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, Thompson CB, Evans RM. PMID: 19833968; PMCID: PMC2819106.
      View in: PubMed   Mentions: 435     Fields:    
    76. Tumor suppression by LKB1: SIK-ness prevents metastasis. Sci Signal. 2009 Sep 01; 2(86):pe55. Shaw RJ. PMID: 19724060.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    77. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer. 2009 08; 9(8):563-75. Shackelford DB, Shaw RJ. PMID: 19629071; PMCID: PMC2756045.
      View in: PubMed   Mentions: 937     Fields:    Translation:HumansAnimalsCells
    78. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11137-42. Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ. PMID: 19541609; PMCID: PMC2708689.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    79. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS One. 2009; 4(2):e4535. Mair W, Panowski SH, Shaw RJ, Dillin A. PMID: 19229346; PMCID: PMC2643252.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    80. LKB1: cancer, polarity, metabolism, and now fertility. Biochem J. 2008 Nov 15; 416(1):e1-3. Shaw RJ. PMID: 18939946; PMCID: PMC2676712.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    81. Raptor swoops in on metabolism. Cell Metab. 2008 Nov; 8(5):343-4. Shaw RJ. PMID: 19046565.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    82. mTOR signaling: RAG GTPases transmit the amino acid signal. Trends Biochem Sci. 2008 Dec; 33(12):565-8. Shaw RJ. PMID: 18929489; PMCID: PMC2677387.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    83. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008 08 08; 134(3):405-15. Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. PMID: 18674809; PMCID: PMC2706130.
      View in: PubMed   Mentions: 534     Fields:    Translation:Animals
    84. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008 Apr 25; 30(2):214-26. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. PMID: 18439900; PMCID: PMC2674027.
      View in: PubMed   Mentions: 1842     Fields:    Translation:HumansAnimalsCells
    85. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16; 444(7117):337-42. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. PMID: 17086191; PMCID: PMC4990206.
      View in: PubMed   Mentions: 1684     Fields:    Translation:AnimalsCells
    86. Glucose metabolism and cancer. Curr Opin Cell Biol. 2006 Dec; 18(6):598-608. Shaw RJ. PMID: 17046224.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimalsCells
    87. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006 May 25; 441(7092):424-30. Shaw RJ, Cantley LC. PMID: 16724053.
      View in: PubMed   Mentions: 859     Fields:    Translation:HumansAnimalsCells
    88. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 09; 310(5754):1642-6. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. PMID: 16308421; PMCID: PMC3074427.
      View in: PubMed   Mentions: 822     Fields:    Translation:HumansAnimalsCells
    89. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem. 2005 Apr 15; 280(15):15158-64. Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD. PMID: 15713674.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    90. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004 Jul; 6(1):91-9. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. PMID: 15261145.
      View in: PubMed   Mentions: 455     Fields:    Translation:AnimalsCells
    91. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3329-35. Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. PMID: 14985505; PMCID: PMC373461.
      View in: PubMed   Mentions: 843     Fields:    Translation:HumansAnimalsCells
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