Francesca Briganti

Title(s)	Assistant Professor, Pediatrics
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
Email	fbriganti@ucsd.edu
ORCID	0000-0001-5738-2642
vCard	Download vCard

Biography

Education and Training

University of Heidelberg , Heidelberg, Germany	PhD	07/2018	Molecular Biology
Sapienza University, Rome	MS	06/2014	Genetics, Molecular Biology
Sapienza University, Rome	BS	07/2012	Genetics, Molecular Biology
Stanford University, Stanford	postdoc	06/2023	Cardiac Biology, Genetics, Molecular Biology

Overview

Dr. Francesca Briganti is a molecular biologist interested in understanding the molecular causes of human diseases and in using this knowledge to design targeted therapeutic strategies. She is an Assistant Professor in the Department of pediatrics with a joint appointment in Genetics and Cardiology. Her scientific interests include cardiac physiology, disease mechanism, and drug development. Her work focuses on the development and application of high-content, high-thourough imaging screening strategies.
Dr. Briganti received her PhD jointly from the EMBL and the University of Heidelberg. During her PhD she studied new targeted therapeutic approaches for Dilated Cardiomyopathy. She identified a new potential therapeutic strategy that has been published and patented. She completed a Postdoctoral Fellowship in the Mercola lab at The Stanford Cardiovascular Institute. Her work is currently supported by the NIH NHLBI.

Websites

Briganti Lab

Research

Research Activities and Funding

Using miRNA to identify new therapeutic pathways for dilated cardiomyopathy
NIH R00HL165099Aug 12, 2024 - Jul 31, 2027
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Alternative Splicing in the Heart: The Therapeutic Potential of Regulating the Regulators. Int J Mol Sci. 2024 Dec 04; 25(23). Briganti F, Wang Z. PMID: 39684734; PMCID: PMC11641712.

View in: PubMed Mentions: Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Nat Commun. 2021 07 09; 12(1):4203. Zhu C, Wu J, Sun H, Briganti F, Meder B, Wei W, Steinmetz LM. PMID: 34244519; PMCID: PMC8270901.

View in: PubMed Mentions: 17 Fields:
Bio Biology Sci Science
Translation:Humans Cells
Author Correction: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs. Nat Med. 2021 Jul; 27(7):1309. Schneider JW, Oommen S, Qureshi MY, Goetsch SC, Pease DR, Sundsbak RS, Guo W, Sun M, Sun H, Kuroyanagi H, Webster DA, Coutts AW, Holst KA, Edwards BS, Newville N, Hathcock MA, Melkamu T, Briganti F, Wei W, Romanelli MG, Fahrenkrug SC, Frantz DE, Olson TM, Steinmetz LM, Carlson DF, Nelson TJ, Wanek Program Preclinical Pipeline. PMID: 34079106.

View in: PubMed Mentions: Fields:
Med Medicine (General)Mol Molecular Biology
Human iPSC modeling of heart disease for drug development. Cell Chem Biol. 2021 03 18; 28(3):271-282. Hnatiuk AP, Briganti F, Staudt DW, Mercola M. PMID: 33740432; PMCID: PMC8054828.

View in: PubMed Mentions: 27 Fields:
Bio Biochemistry Bio Biology Che Chemistry
Translation:Humans Cells
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs. Nat Med. 2020 11; 26(11):1788-1800. Schneider JW, Oommen S, Qureshi MY, Goetsch SC, Pease DR, Sundsbak RS, Guo W, Sun M, Sun H, Kuroyanagi H, Webster DA, Coutts AW, Holst KA, Edwards BS, Newville N, Hathcock MA, Melkamu T, Briganti F, Wei W, Romanelli MG, Fahrenkrug SC, Frantz DE, Olson TM, Steinmetz LM, Carlson DF, Nelson TJ, Wanek Program Preclinical Pipeline. PMID: 33188278; PMCID: PMC9270981.

View in: PubMed Mentions: 41 Fields:
Med Medicine (General)Mol Molecular Biology
Translation:Humans Animals Cells
iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy. Cell Rep. 2020 09 08; 32(10):108117. Briganti F, Sun H, Wei W, Wu J, Zhu C, Liss M, Karakikes I, Rego S, Cipriano A, Snyder M, Meder B, Xu Z, Millat G, Gotthardt M, Mercola M, Steinmetz LM. PMID: 32905764; PMCID: PMC8168789.

View in: PubMed Mentions: 25 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Rep. 2020 07 21; 32(3):107925. Feyen DAM, McKeithan WL, Bruyneel AAN, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen RP, Ginsburg KS, Lam CK, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya PL, Behrens CS, Ranjbarvaziri S, Maas RGC, Greenhaw M, Bernstein D, Wu JC, Bers DM, Eschenhagen T, Metallo CM, Mercola M. PMID: 32697997; PMCID: PMC7437654.

View in: PubMed Mentions: 150 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Mol Cell. 2017 Apr 06; 66(1):22-37.e9. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. PMID: 28344082; PMCID: PMC5387670.

View in: PubMed Mentions: 1109 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype. Nat Commun. 2016 Jan 22; 7:10488. Martone J, Briganti F, Legnini I, Morlando M, Picillo E, Sthandier O, Politano L, Bozzoni I. PMID: 26796035; PMCID: PMC4736020.

View in: PubMed Mentions: 13 Fields:
Bio Biology Sci Science
Translation:Humans Cells