Neal Devaraj

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0359
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Enzymatic Site-Specific Labeling of RNA for Affinity Isolation
    NIH/NIGMS R01GM123285Sep 20, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Amplifying PET Imaging Signals for In Vivo Detection of Pancreatic Beta-cells
    NIH/NIDDK DP2DK111801Sep 25, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Fast in vivo CLICK chemistries for PET imaging
    NIH/NIBIB K01EB010078May 15, 2010 - Apr 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rudd AK, Devaraj N. Traceless synthesis of ceramides in living cells reveals saturation-dependent apoptotic effects. Proc Natl Acad Sci U S A. 2018 Jul 02. PMID: 29967152.
      View in: PubMed
    2. Seoane A, Brea RJ, Fuertes A, Podolsky KA, Devaraj N. Biomimetic Generation and Remodeling of Phospholipid Membranes by Dynamic Imine Chemistry. J Am Chem Soc. 2018 Jun 13. PMID: 29886740.
      View in: PubMed
    3. Wu H, Devaraj N. Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles. Acc Chem Res. 2018 May 15; 51(5):1249-1259. PMID: 29638113.
      View in: PubMed
    4. Zhang D, Zhou CY, Busby KN, Alexander SC, Devaraj N. Light-Activated Control of Translation by Enzymatic Covalent mRNA Labeling. Angew Chem Int Ed Engl. 2018 Mar 05; 57(11):2822-2826. PMID: 29380476.
      View in: PubMed
    5. Devaraj N, Perrin CL. Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides. Chem Sci. 2018 Feb 21; 9(7):1789-1794. PMID: 29675223.
      View in: PubMed
    6. Bhattacharya A, Brea RJ, Devaraj N. De novo vesicle formation and growth: an integrative approach to artificial cells. Chem Sci. 2017 Dec 01; 8(12):7912-7922. PMID: 29619165.
      View in: PubMed
    7. Enomoto T, Brea RJ, Bhattacharya A, Devaraj N. In Situ Lipid Membrane Formation Triggered by Intramolecular Photoinduced Electron Transfer. Langmuir. 2018 Jan 23; 34(3):750-755. PMID: 28982007.
      View in: PubMed
    8. Brea RJ, Devaraj N. Continual reproduction of self-assembling oligotriazole peptide nanomaterials. Nat Commun. 2017 09 28; 8(1):730. PMID: 28959049.
      View in: PubMed
    9. Zhou CY, Alexander SC, Devaraj N. Fluorescent turn-on probes for wash-free mRNA imaging via covalent site-specific enzymatic labeling. Chem Sci. 2017 Oct 01; 8(10):7169-7173. PMID: 29081948.
      View in: PubMed
    10. Ehret F, Zhou CY, Alexander SC, Zhang D, Devaraj N. Site-Specific Covalent Conjugation of Modified mRNA by tRNA Guanine Transglycosylase. Mol Pharm. 2018 Mar 05; 15(3):737-742. PMID: 28749687.
      View in: PubMed
    11. Alexander SC, Devaraj N. Developing a Fluorescent Toolbox To Shed Light on the Mysteries of RNA. Biochemistry. 2017 10 03; 56(39):5185-5193. PMID: 28671838.
      View in: PubMed
    12. Brea RJ, Devaraj N. Tension Promoted Sulfur Exchange for Cellular Delivery. ACS Cent Sci. 2017 Jun 28; 3(6):524-525. PMID: 28691060.
      View in: PubMed
    13. Devaraj N. In Situ Synthesis of Phospholipid Membranes. J Org Chem. 2017 Jun 16; 82(12):5997-6005. PMID: 28467841.
      View in: PubMed
    14. Brea RJ, Cole CM, Lyda BR, Ye L, Prosser RS, Sunahara RK, Devaraj N. In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes. J Am Chem Soc. 2017 03 15; 139(10):3607-3610. PMID: 28263576.
      View in: PubMed
    15. Wu H, Alexander SC, Jin S, Devaraj N. A Bioorthogonal Near-Infrared Fluorogenic Probe for mRNA Detection. J Am Chem Soc. 2016 09 14; 138(36):11429-32. PMID: 27510580.
      View in: PubMed
    16. Wu H, Devaraj N. Mining Proteomes Using Bioorthogonal Probes. Cell Chem Biol. 2016 Jul 21; 23(7):751-753. PMID: 27447043.
      View in: PubMed
    17. Brea RJ, Rudd AK, Devaraj N. Nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8589-94. PMID: 27439858; PMCID: PMC4978229 [Available on 02/02/17].
    18. Hardy MD, Konetski D, Bowman CN, Devaraj N. Ruthenium photoredox-triggered phospholipid membrane formation. Org Biomol Chem. 2016 Jun 15; 14(24):5555-8. PMID: 26924258.
      View in: PubMed
    19. Chowdhuri S, Cole CM, Devaraj N. Encapsulation of Living Cells within Giant Phospholipid Liposomes Formed by the Inverse-Emulsion Technique. Chembiochem. 2016 05 17; 17(10):886-9. PMID: 26919463.
      View in: PubMed
    20. Wu H, Devaraj N. Inverse Electron-Demand Diels-Alder Bioorthogonal Reactions. Top Curr Chem (Cham). 2016 Feb; 374(1):3. PMID: 27572986.
      View in: PubMed
    21. Alexander SC, Busby KN, Cole CM, Zhou CY, Devaraj N. Site-Specific Covalent Labeling of RNA by Enzymatic Transglycosylation. J Am Chem Soc. 2015 Oct 14; 137(40):12756-9. PMID: 26393285.
      View in: PubMed
    22. Cole CM, Brea RJ, Kim YH, Hardy MD, Yang J, Devaraj N. Spontaneous Reconstitution of Functional Transmembrane Proteins During Bioorthogonal Phospholipid Membrane Synthesis. Angew Chem Int Ed Engl. 2015 Oct 19; 54(43):12738-42. PMID: 26316292.
      View in: PubMed
    23. Ehret F, Wu H, Alexander SC, Devaraj N. Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes. J Am Chem Soc. 2015 Jul 22; 137(28):8876-9. PMID: 26132207.
      View in: PubMed
    24. Brea RJ, Hardy MD, Devaraj N. Towards self-assembled hybrid artificial cells: novel bottom-up approaches to functional synthetic membranes. Chemistry. 2015 Sep 01; 21(36):12564-70. PMID: 26149747; PMCID: PMC4617832.
    25. Hardy MD, Yang J, Selimkhanov J, Cole CM, Tsimring LS, Devaraj N. Self-reproducing catalyst drives repeated phospholipid synthesis and membrane growth. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8187-92. PMID: 26100914; PMCID: PMC4500204.
    26. Zhou CY, Wu H, Devaraj N. Rapid access to phospholipid analogs using thiol-yne chemistry. Chem Sci. 2015 Jul 01; 6(7):4365-4372. PMID: 29218208.
      View in: PubMed
    27. Rudd AK, Valls Cuevas JM, Devaraj N. SNAP-Tag-Reactive Lipid Anchors Enable Targeted and Spatiotemporally Controlled Localization of Proteins to Phospholipid Membranes. J Am Chem Soc. 2015 Apr 22; 137(15):4884-7. PMID: 25830488.
      View in: PubMed
    28. Wu H, Cisneros BT, Cole CM, Devaraj N. Bioorthogonal tetrazine-mediated transfer reactions facilitate reaction turnover in nucleic acid-templated detection of microRNA. J Am Chem Soc. 2014 Dec 31; 136(52):17942-5. PMID: 25495860; PMCID: PMC4291768.
    29. Brea RJ, Cole CM, Devaraj N. In situ vesicle formation by native chemical ligation. Angew Chem Int Ed Engl. 2014 Dec 15; 53(51):14102-5. PMID: 25346090; PMCID: PMC4418804.
    30. Wu H, Yang J, Šeckute J, Devaraj N. In situ synthesis of alkenyl tetrazines for highly fluorogenic bioorthogonal live-cell imaging probes. Angew Chem Int Ed Engl. 2014 Jun 02; 53(23):5805-9. PMID: 24764312; PMCID: PMC4104127.
    31. Nichols B, Qin Z, Yang J, Vera DR, Devaraj N. 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers. Chem Commun (Camb). 2014 May 25; 50(40):5215-5217. PMID: 24589653; PMCID: PMC4119763.
    32. Yang J, Liang Y, Šeckute J, Houk KN, Devaraj N. Synthesis and reactivity comparisons of 1-methyl-3-substituted cyclopropene mini-tags for tetrazine bioorthogonal reactions. Chemistry. 2014 Mar 17; 20(12):3365-75. PMID: 24615990; PMCID: PMC4020353.
    33. Seckute J, Devaraj N. Expanding room for tetrazine ligations in the in vivo chemistry toolbox. Curr Opin Chem Biol. 2013 Oct; 17(5):761-7. PMID: 24021760; PMCID: PMC4002580.
    34. Seckute J, Yang J, Devaraj N. Rapid oligonucleotide-templated fluorogenic tetrazine ligations. Nucleic Acids Res. 2013 Aug; 41(15):e148. PMID: 23775794; PMCID: PMC3753649.
    35. Cole CM, Yang J, Šeckute J, Devaraj N. Fluorescent live-cell imaging of metabolically incorporated unnatural cyclopropene-mannosamine derivatives. Chembiochem. 2013 Jan 21; 14(2):205-208. PMID: 23292753; PMCID: PMC4010072.
    36. Yang J, Šeckute J, Cole CM, Devaraj N. Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions. Angew Chem Int Ed Engl. 2012 Jul 23; 51(30):7476-9. PMID: 22696426; PMCID: PMC3431913.
    37. Yang J, Karver MR, Li W, Sahu S, Devaraj N. Metal-catalyzed one-pot synthesis of tetrazines directly from aliphatic nitriles and hydrazine. Angew Chem Int Ed Engl. 2012 May 21; 51(21):5222-5. PMID: 22511586; PMCID: PMC3434974.
    38. Devaraj N, Thurber GM, Keliher EJ, Marinelli B, Weissleder R. Reactive polymer enables efficient in vivo bioorthogonal chemistry. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4762-7. PMID: 22411831; PMCID: PMC3324005.
    39. Budin I, Devaraj N. Membrane assembly driven by a biomimetic coupling reaction. J Am Chem Soc. 2012 Jan 18; 134(2):751-3. PMID: 22239722; PMCID: PMC3262119.
    40. Devaraj N, Weissleder R. Biomedical applications of tetrazine cycloadditions. Acc Chem Res. 2011 Sep 20; 44(9):816-27. PMID: 21627112; PMCID: PMC3166440.
    41. Haun JB, Devaraj N, Marinelli BS, Lee H, Weissleder R. Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry. ACS Nano. 2011 Apr 26; 5(4):3204-13. PMID: 21351804; PMCID: PMC3088084.
    42. Haun JB, Devaraj N, Hilderbrand SA, Lee H, Weissleder R. Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010 Sep; 5(9):660-5. PMID: 20676091; PMCID: PMC2934903.
    43. Han HS, Devaraj N, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG. Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition. J Am Chem Soc. 2010 Jun 16; 132(23):7838-9. PMID: 20481508; PMCID: PMC2892974.
    44. Devaraj N, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R. Bioorthogonal turn-on probes for imaging small molecules inside living cells. Angew Chem Int Ed Engl. 2010 Apr 06; 49(16):2869-72. PMID: 20306505; PMCID: PMC3433403.
    45. Devaraj N, Keliher EJ, Thurber GM, Nahrendorf M, Weissleder R. 18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjug Chem. 2009 Feb; 20(2):397-401. PMID: 19138113; PMCID: PMC2644737.
    46. Devaraj N, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R. Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl. 2009; 48(38):7013-6. PMID: 19697389; PMCID: PMC2790075.
    47. Devaraj N, Weissleder R, Hilderbrand SA. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem. 2008 Dec; 19(12):2297-9. PMID: 19053305; PMCID: PMC2677645.
    48. Decréau RA, Collman JP, Yang Y, Yan Y, Devaraj N. Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry. J Org Chem. 2007 Apr 13; 72(8):2794-802. PMID: 17375955; PMCID: PMC2532528.
    49. Collman JP, Devaraj N, Decréau RA, Yang Y, Yan YL, Ebina W, Eberspacher TA, Chidsey CE. A cytochrome C oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux. Science. 2007 Mar 16; 315(5818):1565-8. PMID: 17363671; PMCID: PMC3064436.
    50. Devaraj N, Decreau RA, Ebina W, Collman JP, Chidsey CE. Rate of interfacial electron transfer through the 1,2,3-triazole linkage. J Phys Chem B. 2006 Aug 17; 110(32):15955-62. PMID: 16898751; PMCID: PMC3434967.
    51. Collman JP, Devaraj N, Eberspacher TP, Chidsey CE. Mixed azide-terminated monolayers: a platform for modifying electrode surfaces. Langmuir. 2006 Mar 14; 22(6):2457-64. PMID: 16519441; PMCID: PMC1513191.
    52. Devaraj N, Dinolfo PH, Chidsey CE, Collman JP. Selective functionalization of independently addressed microelectrodes by electrochemical activation and deactivation of a coupling catalyst. J Am Chem Soc. 2006 Feb 15; 128(6):1794-5. PMID: 16464070; PMCID: PMC1473176.
    53. Devaraj N, Miller GP, Ebina W, Kakaradov B, Collman JP, Kool ET, Chidsey CE. Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. J Am Chem Soc. 2005 Jun 22; 127(24):8600-1. PMID: 15954758; PMCID: PMC3431914.
    54. Collman JP, Devaraj N, Chidsey CE. "Clicking" functionality onto electrode surfaces. Langmuir. 2004 Feb 17; 20(4):1051-3. PMID: 15803676; PMCID: PMC3428800.