Neal Devaraj

Title(s)Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    A Small Molecule Enzyme Replacement for the Treatment of CLN1
    NIH R43NS122619Aug 15, 2021 - Jul 31, 2022
    Role: Co-Principal Investigator
    Illuminating cellular dark matter through the development of novel chemical tools
    NIH R35GM141939Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Targeted Depalmitoylation for the Treatment of NRas-Driven Melanoma
    NIH R43CA250702Sep 21, 2020 - Aug 31, 2021
    Role: Co-Principal Investigator
    Enzymatic Site-Specific Labeling of RNA for Affinity Isolation
    NIH R01GM123285Sep 20, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Amplifying PET Imaging Signals for In Vivo Detection of Pancreatic Beta-cells
    NIH DP2DK111801Sep 25, 2016 - May 31, 2021
    Role: Principal Investigator
    Fast in vivo CLICK chemistries for PET imaging
    NIH K01EB010078May 15, 2010 - Apr 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Control of giant vesicle assemblies by stimuli-responsive lipids. Chem Commun (Camb). 2024 Mar 18. Lee Y, Fracassi A, Devaraj NK. PMID: 38497420.
      View in: PubMed   Mentions:    Fields:    
    2. Chemoselective Esterification of Natural and Prebiotic 1,2-Amino Alcohol Amphiphiles in Water. J Am Chem Soc. 2023 12 13; 145(49):27149-27159. Bhattacharya A, Tanwar L, Fracassi A, Brea RJ, Salvador-Castell M, Khanal S, Sinha SK, Devaraj NK. PMID: 38039527; PMCID: PMC10722506.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Rapid Formation of Non-canonical Phospholipid Membranes by Chemoselective Amide-Forming Ligations with Hydroxylamines. Angew Chem Int Ed Engl. 2024 Jan 02; 63(1):e202311635. Chen J, Brea RJ, Fracassi A, Cho CJ, Wong AM, Salvador-Castell M, Sinha SK, Budin I, Devaraj NK. PMID: 37919232.
      View in: PubMed   Mentions:    Fields:    
    4. Light-Driven Membrane Assembly, Shape-Shifting, and Tissue Formation in Chemically Responsive Synthetic Cells. J Am Chem Soc. 2023 11 29; 145(47):25815-25823. Lee Y, Fracassi A, Devaraj NK. PMID: 37963186; PMCID: PMC10690792.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. RNA-TAG Mediated Protein-RNA Conjugation. Chembiochem. 2023 09 15; 24(18):e202300454. Tota EM, Devaraj NK. PMID: 37500587.
      View in: PubMed   Mentions:    Fields:    
    6. Biomimetic construction of phospholipid membranes by direct aminolysis ligations. Interface Focus. 2023 Oct 06; 13(5):20230019. Souto-Trinei FA, Brea RJ, Devaraj NK. PMID: 37577004; PMCID: PMC10415742.
      View in: PubMed   Mentions:
    7. Sponge-phase Lipid Droplets as Synthetic Organelles: An Ultrafast Study of Hydrogen Bonding and Interfacial Environments. Chemphyschem. 2023 10 17; 24(20):e202300404. Xu C, Fracassi A, Baryiames CP, Bhattacharya A, Devaraj NK, Baiz CR. PMID: 37486881.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Site-Specific Covalent Labeling of DNA Substrates by an RNA Transglycosylase. J Am Chem Soc. 2023 04 12; 145(14):8099-8106. Tota EM, Devaraj NK. PMID: 36988146; PMCID: PMC10103133.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    9. Characterizing the Self-Assembly Properties of Monoolein Lipid Isosteres. J Phys Chem B. 2023 03 02; 127(8):1771-1779. Fracassi A, Podolsky KA, Pandey S, Xu C, Hutchings J, Seifert S, Baiz CR, Sinha SK, Devaraj NK. PMID: 36795462; PMCID: PMC9986874.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    10. Editorial overview: Synthetic biomolecules for probing lipid membranes. Curr Opin Chem Biol. 2023 04; 73:102271. Devaraj NK, Tsukiji S. PMID: 36764234.
      View in: PubMed   Mentions:    Fields:    
    11. Site-specific Covalent Labeling of DNA Substrates by an RNA Transglycosylase. bioRxiv. 2023 Jan 23. Tota EM, Devaraj NK. PMID: 36747847; PMCID: PMC9900779.
      View in: PubMed   Mentions:
    12. Miniaturized Synthetic Palmitoylation Motifs for Small-Molecule Localization in Living Cells. Bioconjug Chem. 2023 01 18; 34(1):169-173. Suzuki S, Yoshikawa M, Sawada S, Devaraj NK, Tsukiji S. PMID: 36534355.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Bioconjugation Strategies for Revealing the Roles of Lipids in Living Cells. Acc Chem Res. 2022 11 01; 55(21):3099-3109. Knittel CH, Devaraj NK. PMID: 36215688; PMCID: PMC10257556.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Light-activated tetrazines enable precision live-cell bioorthogonal chemistry. Nat Chem. 2022 09; 14(9):1078-1085. Liu L, Zhang D, Johnson M, Devaraj NK. PMID: 35788560; PMCID: PMC10198265.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. Rapid and Sequential Dual Oxime Ligation Enables De Novo Formation of Functional Synthetic Membranes from Water-Soluble Precursors. Angew Chem Int Ed Engl. 2022 07 18; 61(29):e202200549. Flores J, Brea RJ, Lamas A, Fracassi A, Salvador-Castell M, Xu C, Baiz CR, Sinha SK, Devaraj NK. PMID: 35546783.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. In Situ Assembly of Transmembrane Proteins from Expressed and Synthetic Components in Giant Unilamellar Vesicles. ACS Chem Biol. 2022 05 20; 17(5):1015-1021. Podolsky KA, Masubuchi T, Debelouchina GT, Hui E, Devaraj NK. PMID: 35482050; PMCID: PMC9255206.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Site-Specific and Enzymatic Cross-Linking of sgRNA Enables Wavelength-Selectable Photoactivated Control of CRISPR Gene Editing. J Am Chem Soc. 2022 Mar 16; 144(10):4487-4495. Zhang D, Liu L, Jin S, Tota E, Li Z, Piao X, Zhang X, Fu XD, Devaraj NK. PMID: 35257575; PMCID: PMC9469474.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    18. Controlling Protein Enrichment in Lipid Sponge Phase Droplets using SNAP-Tag Bioconjugation. Chembiochem. 2022 03 04; 23(5):e202100624. Moinpour M, Fracassi A, Brea RJ, Salvador-Castell M, Pandey S, Edwards MM, Seifert S, Joseph S, Sinha SK, Devaraj NK. PMID: 34936727.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    19. Synthetic probes and chemical tools in sphingolipid research. Curr Opin Chem Biol. 2021 12; 65:126-135. Chen J, Devaraj NK. PMID: 34509716.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Probing the Role of Chirality in Phospholipid Membranes. Chembiochem. 2021 11 16; 22(22):3148-3157. Martin HS, Podolsky KA, Devaraj NK. PMID: 34227722.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. Synthesis of lipid membranes for artificial cells. Nat Rev Chem. 2021 Oct; 5(10):676-694. Podolsky KA, Devaraj NK. PMID: 37118179.
      View in: PubMed   Mentions: 5  
    22. Expression of Fatty Acyl-CoA Ligase Drives One-Pot De Novo Synthesis of Membrane-Bound Vesicles in a Cell-Free Transcription-Translation System. J Am Chem Soc. 2021 07 28; 143(29):11235-11242. Bhattacharya A, Cho CJ, Brea RJ, Devaraj NK. PMID: 34260248.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Introduction: Click Chemistry. Chem Rev. 2021 06 23; 121(12):6697-6698. Devaraj NK, Finn MG. PMID: 34157843.
      View in: PubMed   Mentions: 18     Fields:    
    24. Membrane Mimetic Chemistry in Artificial Cells. J Am Chem Soc. 2021 06 09; 143(22):8223-8231. Vance JA, Devaraj NK. PMID: 34014081.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    25. Chemoenzymatic Generation of Phospholipid Membranes Mediated by Type I Fatty Acid Synthase. J Am Chem Soc. 2021 06 16; 143(23):8533-8537. Khanal S, Brea RJ, Burkart MD, Devaraj NK. PMID: 33978402.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    26. Author Correction: Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation. Nat Commun. 2021 Apr 07; 12(1):2210. Jin S, Brea RJ, Rudd AK, Moon SP, Pratt MR, Devaraj NK. PMID: 33828105; PMCID: PMC8026954.
      View in: PubMed   Mentions:    Fields:    
    27. Lipase mimetic cyclodextrins. Chem Sci. 2020 Nov 19; 12(3):1090-1094. Lee Y, Devaraj NK. PMID: 34163875; PMCID: PMC8179069.
      View in: PubMed   Mentions: 2  
    28. Enzyme-free synthesis of natural phospholipids in water. Nat Chem. 2020 11; 12(11):1029-1034. Liu L, Zou Y, Bhattacharya A, Zhang D, Lang SQ, Houk KN, Devaraj NK. PMID: 33046841; PMCID: PMC8849033.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    29. A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells. J Am Chem Soc. 2020 10 21; 142(42):17887-17891. Rudd AK, Mittal N, Lim EW, Metallo CM, Devaraj NK. PMID: 33044062; PMCID: PMC8849011.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Enzymatic RNA Biotinylation for Affinity Purification and Identification of RNA-Protein Interactions. ACS Chem Biol. 2020 08 21; 15(8):2247-2258. Busby KN, Fulzele A, Zhang D, Bennett EJ, Devaraj NK. PMID: 32706237; PMCID: PMC10198264.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    31. Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32724206.
      View in: PubMed   Mentions: 2     Fields:    
    32. Lipids: chemical tools for their synthesis, modification, and analysis. Chem Soc Rev. 2020 Jul 21; 49(14):4602-4614. Flores J, White BM, Brea RJ, Baskin JM, Devaraj NK. PMID: 32691785; PMCID: PMC7380508.
      View in: PubMed   Mentions: 17     Fields:    
    33. Lipid sponge droplets as programmable synthetic organelles. Proc Natl Acad Sci U S A. 2020 08 04; 117(31):18206-18215. Bhattacharya A, Niederholtmeyer H, Podolsky KA, Bhattacharya R, Song JJ, Brea RJ, Tsai CH, Sinha SK, Devaraj NK. PMID: 32694212; PMCID: PMC7414067.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    34. Inhibition of NRAS Signaling in Melanoma through Direct Depalmitoylation Using Amphiphilic Nucleophiles. ACS Chem Biol. 2020 08 21; 15(8):2079-2086. Vora HD, Johnson M, Brea RJ, Rudd AK, Devaraj NK. PMID: 32568509; PMCID: PMC7556697.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32581380; PMCID: PMC7521455.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimalsCells
    36. Temperature-Dependent Reversible Morphological Transformations in N-Oleoyl β-d-Galactopyranosylamine. J Phys Chem B. 2020 07 02; 124(26):5426-5433. Johnson M, Bhattacharya A, Brea RJ, Podolsky KA, Devaraj NK. PMID: 32437154; PMCID: PMC8849015.
      View in: PubMed   Mentions:    Fields:    
    37. Multiplexed Photoactivation of mRNA with Single-Cell Resolution. ACS Chem Biol. 2020 07 17; 15(7):1773-1779. Zhang D, Jin S, Piao X, Devaraj NK. PMID: 32484653; PMCID: PMC7507792.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    38. Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation. Nat Commun. 2020 06 03; 11(1):2793. Jin S, Brea RJ, Rudd AK, Moon SP, Pratt MR, Devaraj NK. PMID: 32493905; PMCID: PMC7270136.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    39. Enzymatic covalent labeling of RNA with RNA transglycosylation at guanosine (RNA-TAG). Methods Enzymol. 2020; 641:373-399. Busby KN, Devaraj NK. PMID: 32713531; PMCID: PMC10198263.
      View in: PubMed   Mentions: 4     Fields:    
    40. Designer Palmitoylation Motif-Based Self-Localizing Ligand for Sustained Control of Protein Localization in Living Cells and Caenorhabditis elegans. ACS Chem Biol. 2020 04 17; 15(4):837-843. Nakamura A, Oki C, Sawada S, Yoshii T, Kuwata K, Rudd AK, Devaraj NK, Noma K, Tsukiji S. PMID: 32182034; PMCID: PMC8849012.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    41. Laccase-Mediated Catalyzed Fluorescent Reporter Deposition for Live-Cell Imaging. Chembiochem. 2020 01 15; 21(1-2):98-102. Cisneros BT, Devaraj NK. PMID: 31556173; PMCID: PMC7556693.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    42. Tailoring the Shape and Size of Artificial Cells. ACS Nano. 2019 07 23; 13(7):7396-7401. Bhattacharya A, Devaraj NK. PMID: 31298028.
      View in: PubMed   Mentions: 3     Fields:    
    43. Single-Chain β-d-Glycopyranosylamides of Unsaturated Fatty Acids: Self-Assembly Properties and Applications to Artificial Cell Development. J Phys Chem B. 2019 05 02; 123(17):3711-3720. Bhattacharya A, Brea RJ, Song JJ, Bhattacharya R, Sinha SK, Devaraj NK. PMID: 30964979.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    44. A minimal biochemical route towards de novo formation of synthetic phospholipid membranes. Nat Commun. 2019 01 17; 10(1):300. Bhattacharya A, Brea RJ, Niederholtmeyer H, Devaraj NK. PMID: 30655537; PMCID: PMC6336818.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    45. Amphiphile-Mediated Depalmitoylation of Proteins in Living Cells. J Am Chem Soc. 2018 12 19; 140(50):17374-17378. Rudd AK, Brea RJ, Devaraj NK. PMID: 30516377.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    46. Highly Stable Artificial Cells from Galactopyranose-Derived Single-Chain Amphiphiles. J Am Chem Soc. 2018 12 19; 140(50):17356-17360. Brea RJ, Bhattacharya A, Bhattacharya R, Song JJ, Sinha SK, Devaraj NK. PMID: 30495932.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    47. Communication and quorum sensing in non-living mimics of eukaryotic cells. Nat Commun. 2018 11 28; 9(1):5027. Niederholtmeyer H, Chaggan C, Devaraj NK. PMID: 30487584; PMCID: PMC6261949.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    48. The Future of Bioorthogonal Chemistry. ACS Cent Sci. 2018 Aug 22; 4(8):952-959. Devaraj NK. PMID: 30159392; PMCID: PMC6107859.
      View in: PubMed   Mentions: 141  
    49. Traceless synthesis of ceramides in living cells reveals saturation-dependent apoptotic effects. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):7485-7490. Rudd AK, Devaraj NK. PMID: 29967152; PMCID: PMC6055205.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    50. Biomimetic Generation and Remodeling of Phospholipid Membranes by Dynamic Imine Chemistry. J Am Chem Soc. 2018 07 11; 140(27):8388-8391. Seoane A, Brea RJ, Fuertes A, Podolsky KA, Devaraj NK. PMID: 29886740; PMCID: PMC6251970.
      View in: PubMed   Mentions: 6     Fields:    
    51. Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles. Acc Chem Res. 2018 05 15; 51(5):1249-1259. Wu H, Devaraj NK. PMID: 29638113; PMCID: PMC6225996.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    52. Light-Activated Control of Translation by Enzymatic Covalent mRNA Labeling. Angew Chem Int Ed Engl. 2018 03 05; 57(11):2822-2826. Zhang D, Zhou CY, Busby KN, Alexander SC, Devaraj NK. PMID: 29380476; PMCID: PMC6052764.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    53. Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides. Chem Sci. 2018 Feb 21; 9(7):1789-1794. Devaraj NK, Perrin CL. PMID: 29675223; PMCID: PMC5892126.
      View in: PubMed   Mentions: 3  
    54. De novo vesicle formation and growth: an integrative approach to artificial cells. Chem Sci. 2017 Dec 01; 8(12):7912-7922. Bhattacharya A, Brea RJ, Devaraj NK. PMID: 29619165; PMCID: PMC5858084.
      View in: PubMed   Mentions: 13  
    55. In Situ Lipid Membrane Formation Triggered by Intramolecular Photoinduced Electron Transfer. Langmuir. 2018 01 23; 34(3):750-755. Enomoto T, Brea RJ, Bhattacharya A, Devaraj NK. PMID: 28982007.
      View in: PubMed   Mentions: 4     Fields:    
    56. Continual reproduction of self-assembling oligotriazole peptide nanomaterials. Nat Commun. 2017 09 28; 8(1):730. Brea RJ, Devaraj NK. PMID: 28959049; PMCID: PMC5620040.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    57. Fluorescent turn-on probes for wash-free mRNA imaging via covalent site-specific enzymatic labeling. Chem Sci. 2017 Oct 01; 8(10):7169-7173. Zhou CY, Alexander SC, Devaraj NK. PMID: 29081948; PMCID: PMC5635419.
      View in: PubMed   Mentions: 14  
    58. Site-Specific Covalent Conjugation of Modified mRNA by tRNA Guanine Transglycosylase. Mol Pharm. 2018 03 05; 15(3):737-742. Ehret F, Zhou CY, Alexander SC, Zhang D, Devaraj NK. PMID: 28749687.
      View in: PubMed   Mentions: 13     Fields:    
    59. Developing a Fluorescent Toolbox To Shed Light on the Mysteries of RNA. Biochemistry. 2017 10 03; 56(39):5185-5193. Alexander SC, Devaraj NK. PMID: 28671838.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    60. Tension Promoted Sulfur Exchange for Cellular Delivery. ACS Cent Sci. 2017 Jun 28; 3(6):524-525. Brea RJ, Devaraj NK. PMID: 28691060; PMCID: PMC5492249.
      View in: PubMed   Mentions: 1  
    61. In Situ Synthesis of Phospholipid Membranes. J Org Chem. 2017 06 16; 82(12):5997-6005. Devaraj NK. PMID: 28467841.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    62. In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes. J Am Chem Soc. 2017 03 15; 139(10):3607-3610. Brea RJ, Cole CM, Lyda BR, Ye L, Prosser RS, Sunahara RK, Devaraj NK. PMID: 28263576; PMCID: PMC5702554.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    63. A Bioorthogonal Near-Infrared Fluorogenic Probe for mRNA Detection. J Am Chem Soc. 2016 09 14; 138(36):11429-32. Wu H, Alexander SC, Jin S, Devaraj NK. PMID: 27510580.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    64. Mining Proteomes Using Bioorthogonal Probes. Cell Chem Biol. 2016 07 21; 23(7):751-753. Wu H, Devaraj NK. PMID: 27447043.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    65. Nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8589-94. Brea RJ, Rudd AK, Devaraj NK. PMID: 27439858; PMCID: PMC4978229.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    66. Ruthenium photoredox-triggered phospholipid membrane formation. Org Biomol Chem. 2016 Jun 15; 14(24):5555-8. Hardy MD, Konetski D, Bowman CN, Devaraj NK. PMID: 26924258.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    67. Erratum to: M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry. Top Curr Chem (Cham). 2016 04 13; 374(3):23. Carell T, Vrabel M, Yang M, Yang Y, Chen PR, Dommerholt J, Rutjes FPJT, van Delft FL, Herner A, Lin Q, Wu H, Devaraj NK, Kath-Schorr S. PMID: 27573263.
      View in: PubMed   Mentions: 10     Fields:    
    68. Encapsulation of Living Cells within Giant Phospholipid Liposomes Formed by the Inverse-Emulsion Technique. Chembiochem. 2016 05 17; 17(10):886-9. Chowdhuri S, Cole CM, Devaraj NK. PMID: 26919463.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    69. M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry. Top Curr Chem (Cham). 2016 04; 374(2):15. Carell T, Vrabel M, Yang M, Yang Y, Chen PR, Dommerholt J, Rutjes FPJT, van Delft FL, Herner A, Lin Q, Wu H, Devaraj NK, Kath-Schorr S. PMID: 27573140.
      View in: PubMed   Mentions: 6     Fields:    
    70. Inverse Electron-Demand Diels-Alder Bioorthogonal Reactions. Top Curr Chem (Cham). 2016 Feb; 374(1):3. Wu H, Devaraj NK. PMID: 27572986.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    71. Site-Specific Covalent Labeling of RNA by Enzymatic Transglycosylation. J Am Chem Soc. 2015 Oct 14; 137(40):12756-9. Alexander SC, Busby KN, Cole CM, Zhou CY, Devaraj NK. PMID: 26393285.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    72. Spontaneous Reconstitution of Functional Transmembrane Proteins During Bioorthogonal Phospholipid Membrane Synthesis. Angew Chem Int Ed Engl. 2015 Oct 19; 54(43):12738-42. Cole CM, Brea RJ, Kim YH, Hardy MD, Yang J, Devaraj NK. PMID: 26316292; PMCID: PMC5790194.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    73. Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes. J Am Chem Soc. 2015 Jul 22; 137(28):8876-9. Ehret F, Wu H, Alexander SC, Devaraj NK. PMID: 26132207.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    74. Towards self-assembled hybrid artificial cells: novel bottom-up approaches to functional synthetic membranes. Chemistry. 2015 Sep 01; 21(36):12564-70. Brea RJ, Hardy MD, Devaraj NK. PMID: 26149747; PMCID: PMC4617832.
      View in: PubMed   Mentions: 16     Fields:    
    75. Self-reproducing catalyst drives repeated phospholipid synthesis and membrane growth. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8187-92. Hardy MD, Yang J, Selimkhanov J, Cole CM, Tsimring LS, Devaraj NK. PMID: 26100914; PMCID: PMC4500204.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    76. Rapid access to phospholipid analogs using thiol-yne chemistry. Chem Sci. 2015 Jul 01; 6(7):4365-4372. Zhou CY, Wu H, Devaraj NK. PMID: 29218208; PMCID: PMC5707512.
      View in: PubMed   Mentions: 7  
    77. SNAP-Tag-Reactive Lipid Anchors Enable Targeted and Spatiotemporally Controlled Localization of Proteins to Phospholipid Membranes. J Am Chem Soc. 2015 Apr 22; 137(15):4884-7. Rudd AK, Valls Cuevas JM, Devaraj NK. PMID: 25830488.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    78. Bioorthogonal tetrazine-mediated transfer reactions facilitate reaction turnover in nucleic acid-templated detection of microRNA. J Am Chem Soc. 2014 Dec 31; 136(52):17942-5. Wu H, Cisneros BT, Cole CM, Devaraj NK. PMID: 25495860; PMCID: PMC4291768.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    79. In situ vesicle formation by native chemical ligation. Angew Chem Int Ed Engl. 2014 Dec 15; 53(51):14102-5. Brea RJ, Cole CM, Devaraj NK. PMID: 25346090; PMCID: PMC4418804.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    80. In situ synthesis of alkenyl tetrazines for highly fluorogenic bioorthogonal live-cell imaging probes. Angew Chem Int Ed Engl. 2014 Jun 02; 53(23):5805-9. Wu H, Yang J, Šeckute J, Devaraj NK. PMID: 24764312; PMCID: PMC4104127.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    81. 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers. Chem Commun (Camb). 2014 May 25; 50(40):5215-5217. Nichols B, Qin Z, Yang J, Vera DR, Devaraj NK. PMID: 24589653; PMCID: PMC4119763.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    82. Synthesis and reactivity comparisons of 1-methyl-3-substituted cyclopropene mini-tags for tetrazine bioorthogonal reactions. Chemistry. 2014 Mar 17; 20(12):3365-75. Yang J, Liang Y, Šeckute J, Houk KN, Devaraj NK. PMID: 24615990; PMCID: PMC4020353.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    83. Expanding room for tetrazine ligations in the in vivo chemistry toolbox. Curr Opin Chem Biol. 2013 Oct; 17(5):761-7. Seckute J, Devaraj NK. PMID: 24021760; PMCID: PMC4002580.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    84. Rapid oligonucleotide-templated fluorogenic tetrazine ligations. Nucleic Acids Res. 2013 Aug; 41(15):e148. Seckute J, Yang J, Devaraj NK. PMID: 23775794; PMCID: PMC3753649.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    85. Fluorescent live-cell imaging of metabolically incorporated unnatural cyclopropene-mannosamine derivatives. Chembiochem. 2013 Jan 21; 14(2):205-208. Cole CM, Yang J, Šeckute J, Devaraj NK. PMID: 23292753; PMCID: PMC4010072.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    86. Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions. Angew Chem Int Ed Engl. 2012 Jul 23; 51(30):7476-9. Yang J, Šeckute J, Cole CM, Devaraj NK. PMID: 22696426; PMCID: PMC3431913.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    87. Metal-catalyzed one-pot synthesis of tetrazines directly from aliphatic nitriles and hydrazine. Angew Chem Int Ed Engl. 2012 May 21; 51(21):5222-5. Yang J, Karver MR, Li W, Sahu S, Devaraj NK. PMID: 22511586; PMCID: PMC3434974.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    88. Reactive polymer enables efficient in vivo bioorthogonal chemistry. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4762-7. Devaraj NK, Thurber GM, Keliher EJ, Marinelli B, Weissleder R. PMID: 22411831; PMCID: PMC3324005.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    89. Membrane assembly driven by a biomimetic coupling reaction. J Am Chem Soc. 2012 Jan 18; 134(2):751-3. Budin I, Devaraj NK. PMID: 22239722; PMCID: PMC3262119.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    90. Biomedical applications of tetrazine cycloadditions. Acc Chem Res. 2011 Sep 20; 44(9):816-27. Devaraj NK, Weissleder R. PMID: 21627112; PMCID: PMC3166440.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansCells
    91. Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry. ACS Nano. 2011 Apr 26; 5(4):3204-13. Haun JB, Devaraj NK, Marinelli BS, Lee H, Weissleder R. PMID: 21351804; PMCID: PMC3088084.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    92. Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010 Sep; 5(9):660-5. Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R. PMID: 20676091; PMCID: PMC2934903.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    93. Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition. J Am Chem Soc. 2010 Jun 16; 132(23):7838-9. Han HS, Devaraj NK, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG. PMID: 20481508; PMCID: PMC2892974.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    94. Bioorthogonal turn-on probes for imaging small molecules inside living cells. Angew Chem Int Ed Engl. 2010 Apr 06; 49(16):2869-72. Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R. PMID: 20306505; PMCID: PMC3433403.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    95. 18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjug Chem. 2009 Feb; 20(2):397-401. Devaraj NK, Keliher EJ, Thurber GM, Nahrendorf M, Weissleder R. PMID: 19138113; PMCID: PMC2644737.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    96. Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl. 2009; 48(38):7013-6. Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R. PMID: 19697389; PMCID: PMC2790075.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    97. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem. 2008 Dec; 19(12):2297-9. Devaraj NK, Weissleder R, Hilderbrand SA. PMID: 19053305; PMCID: PMC2677645.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansCells
    98. Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry. J Org Chem. 2007 Apr 13; 72(8):2794-802. Decréau RA, Collman JP, Yang Y, Yan Y, Devaraj NK. PMID: 17375955; PMCID: PMC2532528.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    99. A cytochrome C oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux. Science. 2007 Mar 16; 315(5818):1565-8. Collman JP, Devaraj NK, Decréau RA, Yang Y, Yan YL, Ebina W, Eberspacher TA, Chidsey CE. PMID: 17363671; PMCID: PMC3064436.
      View in: PubMed   Mentions: 87     Fields:    Translation:Cells
    100. Rate of interfacial electron transfer through the 1,2,3-triazole linkage. J Phys Chem B. 2006 Aug 17; 110(32):15955-62. Devaraj NK, Decreau RA, Ebina W, Collman JP, Chidsey CE. PMID: 16898751; PMCID: PMC3434967.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    101. Mixed azide-terminated monolayers: a platform for modifying electrode surfaces. Langmuir. 2006 Mar 14; 22(6):2457-64. Collman JP, Devaraj NK, Eberspacher TP, Chidsey CE. PMID: 16519441; PMCID: PMC1513191.
      View in: PubMed   Mentions: 37     Fields:    
    102. Selective functionalization of independently addressed microelectrodes by electrochemical activation and deactivation of a coupling catalyst. J Am Chem Soc. 2006 Feb 15; 128(6):1794-5. Devaraj NK, Dinolfo PH, Chidsey CE, Collman JP. PMID: 16464070; PMCID: PMC1473176.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    103. Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. J Am Chem Soc. 2005 Jun 22; 127(24):8600-1. Devaraj NK, Miller GP, Ebina W, Kakaradov B, Collman JP, Kool ET, Chidsey CE. PMID: 15954758; PMCID: PMC3431914.
      View in: PubMed   Mentions: 16     Fields:    
    104. "Clicking" functionality onto electrode surfaces. Langmuir. 2004 Feb 17; 20(4):1051-3. Collman JP, Devaraj NK, Chidsey CE. PMID: 15803676; PMCID: PMC3428800.
      View in: PubMed   Mentions: 44     Fields:    
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