Neal Devaraj

InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0359
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Enzymatic Site-Specific Labeling of RNA for Affinity Isolation
    NIH/NIGMS R01GM123285Sep 20, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Amplifying PET Imaging Signals for In Vivo Detection of Pancreatic Beta-cells
    NIH/NIDDK DP2DK111801Sep 25, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Fast in vivo CLICK chemistries for PET imaging
    NIH/NIBIB K01EB010078May 15, 2010 - Apr 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Devaraj NK. The Future of Bioorthogonal Chemistry. ACS Cent Sci. 2018 Aug 22; 4(8):952-959. PMID: 30159392.
      View in: PubMed
    2. Rudd AK, Devaraj NK. Traceless synthesis of ceramides in living cells reveals saturation-dependent apoptotic effects. Proc Natl Acad Sci U S A. 2018 Jul 02. PMID: 29967152.
      View in: PubMed
    3. Seoane A, Brea RJ, Fuertes A, Podolsky KA, Devaraj NK. Biomimetic Generation and Remodeling of Phospholipid Membranes by Dynamic Imine Chemistry. J Am Chem Soc. 2018 Jun 13. PMID: 29886740.
      View in: PubMed
    4. Wu H, Devaraj NK. Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles. Acc Chem Res. 2018 May 15; 51(5):1249-1259. PMID: 29638113.
      View in: PubMed
    5. Zhang D, Zhou CY, Busby KN, Alexander SC, Devaraj NK. Light-Activated Control of Translation by Enzymatic Covalent mRNA Labeling. Angew Chem Int Ed Engl. 2018 Mar 05; 57(11):2822-2826. PMID: 29380476.
      View in: PubMed
    6. Devaraj NK, Perrin CL. Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides. Chem Sci. 2018 Feb 21; 9(7):1789-1794. PMID: 29675223.
      View in: PubMed
    7. Bhattacharya A, Brea RJ, Devaraj NK. De novo vesicle formation and growth: an integrative approach to artificial cells. Chem Sci. 2017 Dec 01; 8(12):7912-7922. PMID: 29619165.
      View in: PubMed
    8. Enomoto T, Brea RJ, Bhattacharya A, Devaraj NK. In Situ Lipid Membrane Formation Triggered by Intramolecular Photoinduced Electron Transfer. Langmuir. 2018 Jan 23; 34(3):750-755. PMID: 28982007.
      View in: PubMed
    9. Brea RJ, Devaraj NK. Continual reproduction of self-assembling oligotriazole peptide nanomaterials. Nat Commun. 2017 09 28; 8(1):730. PMID: 28959049.
      View in: PubMed
    10. Zhou CY, Alexander SC, Devaraj NK. Fluorescent turn-on probes for wash-free mRNA imaging via covalent site-specific enzymatic labeling. Chem Sci. 2017 Oct 01; 8(10):7169-7173. PMID: 29081948.
      View in: PubMed
    11. Ehret F, Zhou CY, Alexander SC, Zhang D, Devaraj NK. Site-Specific Covalent Conjugation of Modified mRNA by tRNA Guanine Transglycosylase. Mol Pharm. 2018 Mar 05; 15(3):737-742. PMID: 28749687.
      View in: PubMed
    12. Alexander SC, Devaraj NK. Developing a Fluorescent Toolbox To Shed Light on the Mysteries of RNA. Biochemistry. 2017 10 03; 56(39):5185-5193. PMID: 28671838.
      View in: PubMed
    13. Brea RJ, Devaraj NK. Tension Promoted Sulfur Exchange for Cellular Delivery. ACS Cent Sci. 2017 Jun 28; 3(6):524-525. PMID: 28691060.
      View in: PubMed
    14. Devaraj NK. In Situ Synthesis of Phospholipid Membranes. J Org Chem. 2017 Jun 16; 82(12):5997-6005. PMID: 28467841.
      View in: PubMed
    15. Brea RJ, Cole CM, Lyda BR, Ye L, Prosser RS, Sunahara RK, Devaraj NK. In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes. J Am Chem Soc. 2017 03 15; 139(10):3607-3610. PMID: 28263576.
      View in: PubMed
    16. Wu H, Alexander SC, Jin S, Devaraj NK. A Bioorthogonal Near-Infrared Fluorogenic Probe for mRNA Detection. J Am Chem Soc. 2016 09 14; 138(36):11429-32. PMID: 27510580.
      View in: PubMed
    17. Wu H, Devaraj NK. Mining Proteomes Using Bioorthogonal Probes. Cell Chem Biol. 2016 Jul 21; 23(7):751-753. PMID: 27447043.
      View in: PubMed
    18. Brea RJ, Rudd AK, Devaraj NK. Nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8589-94. PMID: 27439858; PMCID: PMC4978229 [Available on 02/02/17].
    19. Hardy MD, Konetski D, Bowman CN, Devaraj NK. Ruthenium photoredox-triggered phospholipid membrane formation. Org Biomol Chem. 2016 Jun 15; 14(24):5555-8. PMID: 26924258.
      View in: PubMed
    20. Chowdhuri S, Cole CM, Devaraj NK. Encapsulation of Living Cells within Giant Phospholipid Liposomes Formed by the Inverse-Emulsion Technique. Chembiochem. 2016 05 17; 17(10):886-9. PMID: 26919463.
      View in: PubMed
    21. Wu H, Devaraj NK. Inverse Electron-Demand Diels-Alder Bioorthogonal Reactions. Top Curr Chem (Cham). 2016 Feb; 374(1):3. PMID: 27572986.
      View in: PubMed
    22. Alexander SC, Busby KN, Cole CM, Zhou CY, Devaraj NK. Site-Specific Covalent Labeling of RNA by Enzymatic Transglycosylation. J Am Chem Soc. 2015 Oct 14; 137(40):12756-9. PMID: 26393285.
      View in: PubMed
    23. Cole CM, Brea RJ, Kim YH, Hardy MD, Yang J, Devaraj NK. Spontaneous Reconstitution of Functional Transmembrane Proteins During Bioorthogonal Phospholipid Membrane Synthesis. Angew Chem Int Ed Engl. 2015 Oct 19; 54(43):12738-42. PMID: 26316292.
      View in: PubMed
    24. Ehret F, Wu H, Alexander SC, Devaraj NK. Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes. J Am Chem Soc. 2015 Jul 22; 137(28):8876-9. PMID: 26132207.
      View in: PubMed
    25. Brea RJ, Hardy MD, Devaraj NK. Towards self-assembled hybrid artificial cells: novel bottom-up approaches to functional synthetic membranes. Chemistry. 2015 Sep 01; 21(36):12564-70. PMID: 26149747; PMCID: PMC4617832.
    26. Hardy MD, Yang J, Selimkhanov J, Cole CM, Tsimring LS, Devaraj NK. Self-reproducing catalyst drives repeated phospholipid synthesis and membrane growth. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8187-92. PMID: 26100914; PMCID: PMC4500204.
    27. Zhou CY, Wu H, Devaraj NK. Rapid access to phospholipid analogs using thiol-yne chemistry. Chem Sci. 2015 Jul 01; 6(7):4365-4372. PMID: 29218208.
      View in: PubMed
    28. Rudd AK, Valls Cuevas JM, Devaraj NK. SNAP-Tag-Reactive Lipid Anchors Enable Targeted and Spatiotemporally Controlled Localization of Proteins to Phospholipid Membranes. J Am Chem Soc. 2015 Apr 22; 137(15):4884-7. PMID: 25830488.
      View in: PubMed
    29. Wu H, Cisneros BT, Cole CM, Devaraj NK. Bioorthogonal tetrazine-mediated transfer reactions facilitate reaction turnover in nucleic acid-templated detection of microRNA. J Am Chem Soc. 2014 Dec 31; 136(52):17942-5. PMID: 25495860; PMCID: PMC4291768.
    30. Brea RJ, Cole CM, Devaraj NK. In situ vesicle formation by native chemical ligation. Angew Chem Int Ed Engl. 2014 Dec 15; 53(51):14102-5. PMID: 25346090; PMCID: PMC4418804.
    31. Wu H, Yang J, Šeckute J, Devaraj NK. In situ synthesis of alkenyl tetrazines for highly fluorogenic bioorthogonal live-cell imaging probes. Angew Chem Int Ed Engl. 2014 Jun 02; 53(23):5805-9. PMID: 24764312; PMCID: PMC4104127.
    32. Nichols B, Qin Z, Yang J, Vera DR, Devaraj NK. 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers. Chem Commun (Camb). 2014 May 25; 50(40):5215-5217. PMID: 24589653; PMCID: PMC4119763.
    33. Yang J, Liang Y, Šeckute J, Houk KN, Devaraj NK. Synthesis and reactivity comparisons of 1-methyl-3-substituted cyclopropene mini-tags for tetrazine bioorthogonal reactions. Chemistry. 2014 Mar 17; 20(12):3365-75. PMID: 24615990; PMCID: PMC4020353.
    34. Seckute J, Devaraj NK. Expanding room for tetrazine ligations in the in vivo chemistry toolbox. Curr Opin Chem Biol. 2013 Oct; 17(5):761-7. PMID: 24021760; PMCID: PMC4002580.
    35. Seckute J, Yang J, Devaraj NK. Rapid oligonucleotide-templated fluorogenic tetrazine ligations. Nucleic Acids Res. 2013 Aug; 41(15):e148. PMID: 23775794; PMCID: PMC3753649.
    36. Cole CM, Yang J, Šeckute J, Devaraj NK. Fluorescent live-cell imaging of metabolically incorporated unnatural cyclopropene-mannosamine derivatives. Chembiochem. 2013 Jan 21; 14(2):205-208. PMID: 23292753; PMCID: PMC4010072.
    37. Yang J, Šeckute J, Cole CM, Devaraj NK. Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions. Angew Chem Int Ed Engl. 2012 Jul 23; 51(30):7476-9. PMID: 22696426; PMCID: PMC3431913.
    38. Yang J, Karver MR, Li W, Sahu S, Devaraj NK. Metal-catalyzed one-pot synthesis of tetrazines directly from aliphatic nitriles and hydrazine. Angew Chem Int Ed Engl. 2012 May 21; 51(21):5222-5. PMID: 22511586; PMCID: PMC3434974.
    39. Devaraj NK, Thurber GM, Keliher EJ, Marinelli B, Weissleder R. Reactive polymer enables efficient in vivo bioorthogonal chemistry. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4762-7. PMID: 22411831; PMCID: PMC3324005.
    40. Budin I, Devaraj NK. Membrane assembly driven by a biomimetic coupling reaction. J Am Chem Soc. 2012 Jan 18; 134(2):751-3. PMID: 22239722; PMCID: PMC3262119.
    41. Devaraj NK, Weissleder R. Biomedical applications of tetrazine cycloadditions. Acc Chem Res. 2011 Sep 20; 44(9):816-27. PMID: 21627112; PMCID: PMC3166440.
    42. Haun JB, Devaraj NK, Marinelli BS, Lee H, Weissleder R. Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry. ACS Nano. 2011 Apr 26; 5(4):3204-13. PMID: 21351804; PMCID: PMC3088084.
    43. Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R. Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010 Sep; 5(9):660-5. PMID: 20676091; PMCID: PMC2934903.
    44. Han HS, Devaraj NK, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG. Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition. J Am Chem Soc. 2010 Jun 16; 132(23):7838-9. PMID: 20481508; PMCID: PMC2892974.
    45. Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R. Bioorthogonal turn-on probes for imaging small molecules inside living cells. Angew Chem Int Ed Engl. 2010 Apr 06; 49(16):2869-72. PMID: 20306505; PMCID: PMC3433403.
    46. Devaraj NK, Keliher EJ, Thurber GM, Nahrendorf M, Weissleder R. 18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjug Chem. 2009 Feb; 20(2):397-401. PMID: 19138113; PMCID: PMC2644737.
    47. Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R. Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl. 2009; 48(38):7013-6. PMID: 19697389; PMCID: PMC2790075.
    48. Devaraj NK, Weissleder R, Hilderbrand SA. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem. 2008 Dec; 19(12):2297-9. PMID: 19053305; PMCID: PMC2677645.
    49. Decréau RA, Collman JP, Yang Y, Yan Y, Devaraj NK. Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry. J Org Chem. 2007 Apr 13; 72(8):2794-802. PMID: 17375955; PMCID: PMC2532528.
    50. Collman JP, Devaraj NK, Decréau RA, Yang Y, Yan YL, Ebina W, Eberspacher TA, Chidsey CE. A cytochrome C oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux. Science. 2007 Mar 16; 315(5818):1565-8. PMID: 17363671; PMCID: PMC3064436.
    51. Devaraj NK, Decreau RA, Ebina W, Collman JP, Chidsey CE. Rate of interfacial electron transfer through the 1,2,3-triazole linkage. J Phys Chem B. 2006 Aug 17; 110(32):15955-62. PMID: 16898751; PMCID: PMC3434967.
    52. Collman JP, Devaraj NK, Eberspacher TP, Chidsey CE. Mixed azide-terminated monolayers: a platform for modifying electrode surfaces. Langmuir. 2006 Mar 14; 22(6):2457-64. PMID: 16519441; PMCID: PMC1513191.
    53. Devaraj NK, Dinolfo PH, Chidsey CE, Collman JP. Selective functionalization of independently addressed microelectrodes by electrochemical activation and deactivation of a coupling catalyst. J Am Chem Soc. 2006 Feb 15; 128(6):1794-5. PMID: 16464070; PMCID: PMC1473176.
    54. Devaraj NK, Miller GP, Ebina W, Kakaradov B, Collman JP, Kool ET, Chidsey CE. Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. J Am Chem Soc. 2005 Jun 22; 127(24):8600-1. PMID: 15954758; PMCID: PMC3431914.
    55. Collman JP, Devaraj NK, Chidsey CE. "Clicking" functionality onto electrode surfaces. Langmuir. 2004 Feb 17; 20(4):1051-3. PMID: 15803676; PMCID: PMC3428800.