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    Kun-liang Guan

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-822-7945
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Ph.D.Purdue University

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Molecular Mechanism and Therapy for Ocular Melanoma
      NIH/NCI R01CA217642Mar 14, 2017 - Feb 28, 2022
      Role: Co-Principal Investigator
      The mTOR and Hippo pathway in cell growth and cancer
      NIH/NCI R35CA196878Aug 5, 2015 - Jul 31, 2022
      Role: Principal Investigator
      Regulation of the Hippo pathway and its role in uveal melanoma
      NIH/NEI R01EY022611Sep 1, 2012 - Aug 31, 2016
      Role: Principal Investigator
      Regulation and function of the YAP transcription co-activator oncoprotein
      NIH/NCI R01CA132809Apr 8, 2008 - Feb 28, 2018
      Role: Principal Investigator
      Rag GTPases in mTOR regulation and physiological functions
      NIH/NCI R01CA108941Sep 3, 2004 - Jun 30, 2019
      Role: Principal Investigator
      S6K and mTOR as targets for tuberous sclerosis
      NIH/NCI R41CA101611Jul 1, 2003 - Jun 30, 2004
      Role: Principal Investigator
      Regulation of Ras and Rheb modification by GCN2
      NIH/NIGMS R01GM062694Jul 1, 2000 - Jun 30, 2012
      Role: Principal Investigator
      REGULATION OF PROTEIN TYROSINE PHOSPHORYLATION IN YEAST
      NIH/NIGMS R01GM055642May 1, 1997 - Apr 30, 2001
      Role: Principal Investigator
      Protein phosphorylation and growth factor function
      NIH/NIGMS R01GM051586Aug 1, 1994 - Nov 30, 2019
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan K. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002. PMID: 28752853.
        View in: PubMed
      2. Jin Y, Chen Y, Zhao S, Guan K, Zhuang Y, Zhou W, Wu X, Xu T. DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):7408-7413. PMID: 28645898.
        View in: PubMed
      3. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan K, Ren B. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635. PMID: 28417999.
        View in: PubMed
      4. Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan K, Xu P. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 Apr; 19(4):362-374. PMID: 28346439.
        View in: PubMed
      5. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan K. Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Res. 2017 May 01; 77(9):2413-2423. PMID: 28249901.
        View in: PubMed
      6. Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan K. L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration. Mol Cell Biol. 2017 Jan 30. PMID: 28137912.
        View in: PubMed
      7. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan K, Haybaeck J, Datz C, Zhang K, Karin M. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 Jan 27. PMID: 28130546.
        View in: PubMed
      8. Ma X, Zhang S, He L, Rong Y, Wilz Brier L, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan K, Li D, Zhong Q. MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 2017 Jan 06; 0. PMID: 28059666.
        View in: PubMed
      9. Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan K. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep. 2017 Jan; 18(1):72-86. PMID: 27979971.
        View in: PubMed
      10. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan K. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. PMID: 27912060.
        View in: PubMed
      11. Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV, Guan K. Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell. 2016 Dec 01; 64(5):993-1008. PMID: 27912098.
        View in: PubMed
      12. Lin HP, Cheng ZL, He RY, Song L, Tian MX, Zhou L, S Groh B, Liu W, Ji MB, Ding C, Shi YH, Guan K, Ye D, Xiong Y. Destabilization of fatty acid synthase by acetylation inhibits de novo lipogenesis and tumor cell growth. Cancer Res. 2016 Oct 10. PMID: 27758890.
        View in: PubMed
      13. Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan K, Li YJ, Chien S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41):11525-11530. PMID: 27671657.
        View in: PubMed
      14. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng Z, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan K. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 Sep 2; 291(36):18947-58. PMID: 27382053.
        View in: PubMed
      15. Hong AW, Meng Z, Guan K. The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol. 2016 Jun; 13(6):324-37. PMID: 27147489.
        View in: PubMed
      16. Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XH, Guan K, Zou J, Xu P. Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes Dev. 2016 May 1; 30(9):1086-100. PMID: 27125670.
        View in: PubMed
      17. Zha Z, Han XR, Smith MD, Lei QY, Guan K, Xiong Y. Hypertension-associated C825T polymorphism impairs the function of Gß3 to target GRK2 ubiquitination. Cell Discov. 2016; 2:16005. PMID: 27462452.
        View in: PubMed
      18. Fu V, Moroishi T, Guan K. Glycoholics Anonymous: Cancer Sobers Up with mTORC1. Cancer Cell. 2016 Apr 11; 29(4):432-4. PMID: 27070696.
        View in: PubMed
      19. Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan K, Yang P, Yu H, Ye D. SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Rep. 2016 Jun; 17(6):811-22. PMID: 27113762.
        View in: PubMed
      20. Diao Y, Li B, Meng Z, Jung I, Lee AY, Dixon J, Maliskova L, Guan K, Shen Y, Ren B. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 2016 Mar; 26(3):397-405. PMID: 26813977.
        View in: PubMed
      21. Yuan HX, Guan K. Structural insights of mTOR complex 1. Cell Res. 2016 Mar; 26(3):267-8. PMID: 26794870.
        View in: PubMed
      22. Meng Z, Moroishi T, Guan K. Mechanisms of Hippo pathway regulation. Genes Dev. 2016 Jan 1; 30(1):1-17. PMID: 26728553.
        View in: PubMed
      23. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652; PMCID: PMC4835977 [Available on 01/21/17].
      24. Wang P, Wu J, Ma S, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan K, Ye D, Xiong Y. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22; 13(11):2353-61. PMID: 26686626.
        View in: PubMed
      25. Hansen CG, Ng YL, Lam WL, Plouffe SW, Guan K. The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Res. 2015 Dec; 25(12):1299-313. PMID: 26611634.
        View in: PubMed
      26. Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan K. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev. 2015 Nov 15; 29(22):2362-76. PMID: 26588989.
        View in: PubMed
      27. Yu FX, Zhao B, Guan K. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 2015 Nov 5; 163(4):811-28. PMID: 26544935.
        View in: PubMed
      28. Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan K. Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015 Nov; 13(11):e1002287. PMID: 26539968.
        View in: PubMed
      29. Yuan HX, Guan K. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015 Nov; 5(11):1127-9. PMID: 26526694.
        View in: PubMed
      30. Ma T, Li J, Xu Y, Yu C, Xu T, Wang H, Liu K, Cao N, Nie BM, Zhu SY, Xu S, Li K, Wei WG, Wu Y, Guan K, Ding S. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nat Cell Biol. 2015 Nov; 17(11):1379-87. PMID: 26502054.
        View in: PubMed
      31. Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HW, Mo JS, Lu W, Lu S, Flores F, Yu FX, Halder G, Guan K. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015; 6:8357. PMID: 26437443.
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      32. Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan K, Pende M, Panasyuk G. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015; 6:8283. PMID: 26387534.
        View in: PubMed
      33. Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan K. Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015 Sep; 13(9):e1002243. PMID: 26356530.
        View in: PubMed
      34. Ha J, Guan K, Kim J. AMPK and autophagy in glucose/glycogen metabolism. Mol Aspects Med. 2015 Dec; 46:46-62. PMID: 26297963.
        View in: PubMed
      35. Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan K. Alternative Wnt Signaling Activates YAP/TAZ. Cell. 2015 Aug 13; 162(4):780-94. PMID: 26276632.
        View in: PubMed
      36. Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX, Xu Y, Guan K. Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Cell Res. 2015 Aug; 25(8):985-8. PMID: 26206313.
        View in: PubMed
      37. Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan K. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015 Aug; 16(8):975-85. PMID: 26116754.
        View in: PubMed
      38. Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan K. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84. PMID: 26109050.
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      39. Qi Q, Li DY, Luo HR, Guan K, Ye K. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proc Natl Acad Sci U S A. 2015 Jun 9; 112(23):7255-60. PMID: 26039999.
        View in: PubMed
      40. Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan K, Lei QY, Xiong Y. A Non-Canonical Function of Gß as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Mol Cell. 2015 Jun 4; 58(5):794-803. PMID: 25982117.
        View in: PubMed
      41. Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan K. D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarget. 2015 Apr 20; 6(11):8606-20. PMID: 25825982.
        View in: PubMed
      42. Zhou X, Wang S, Wang Z, Feng X, Liu P, Lv XB, Li F, Yu FX, Sun Y, Yuan H, Zhu H, Xiong Y, Lei QY, Guan K. Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest. 2015 May 1; 125(5):2123-35. PMID: 25893606.
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      43. Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan K. Corrigendum: Inhibition of a-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2015 Apr 15; 29(8):887. PMID: 25877923.
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      44. Zhou Q, Li L, Zhao B, Guan K. The hippo pathway in heart development, regeneration, and diseases. Circ Res. 2015 Apr 10; 116(8):1431-47. PMID: 25858067.
        View in: PubMed
      45. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan K, Karin M, Lee JH. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015; 5:9502. PMID: 25819761.
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      46. Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan K. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015 Apr; 17(4):500-10. PMID: 25751140.
        View in: PubMed
      47. Yang H, Zhou L, Shi Q, Zhao Y, Lin H, Zhang M, Zhao S, Yang Y, Ling ZQ, Guan K, Xiong Y, Ye D. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO J. 2015 Apr 15; 34(8):1110-25. PMID: 25755250.
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      48. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan K, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 5; 519(7541):57-62. PMID: 25731159.
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      49. Jewell JL, Flores F, Guan K. Micro(RNA) Managing by mTORC1. Mol Cell. 2015 Feb 19; 57(4):575-6. PMID: 25699705.
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      50. Plouffe SW, Hong AW, Guan K. Disease implications of the Hippo/YAP pathway. Trends Mol Med. 2015 Apr; 21(4):212-22. PMID: 25702974.
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      51. Wang Y, Xiao M, Chen X, Chen L, Xu Y, Lv L, Wang P, Yang H, Ma S, Lin H, Jiao B, Ren R, Ye D, Guan K, Xiong Y. WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress Leukemia Cell Proliferation. Mol Cell. 2015 Feb 19; 57(4):662-73. PMID: 25601757.
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      52. Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan K. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015 Jan 9; 347(6218):194-8. PMID: 25567907.
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      53. Kim YC, Guan K. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015 Jan 2; 125(1):25-32. PMID: 25654547.
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      54. Lyubasyuk V, Ouyang H, Yu FX, Guan K, Zhang K. YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations. Mol Cell Oncol. 2015 Jan-Mar; 2(1):e970957. PMID: 27308390.
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      55. Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan K, Karin M, Budanov AV. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20; 9(4):1281-91. PMID: 25457612.
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      56. Zhao D, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y, Guan K, Lei QY. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014 Dec 1; 124(12):5453-65. PMID: 25384215.
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      57. Yu FX, Meng Z, Plouffe SW, Guan K. Hippo pathway regulation of gastrointestinal tissues. Annu Rev Physiol. 2015 Feb 10; 77:201-27. PMID: 25293527.
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      58. Gao Y, Zhang W, Han X, Li F, Wang X, Wang R, Fang Z, Tong X, Yao S, Li F, Feng Y, Sun Y, Hou Y, Yang Z, Guan K, Chen H, Zhang L, Ji H. YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nat Commun. 2014; 5:4629. PMID: 25115923.
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      59. Yang H, Lin H, Xu H, Zhang L, Cheng L, Wen B, Shou J, Guan K, Xiong Y, Ye D. TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Res. 2014 Aug; 24(8):1017-20. PMID: 24971736.
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      60. Yu FX, Zhang K, Guan K. YAP as oncotarget in uveal melanoma. Oncoscience. 2014; 1(7):480-1. PMID: 25594048.
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      61. Luk JM, Guan K. An alternative DNA damage pathway to apoptosis in hematological cancers. Nat Med. 2014 Jun; 20(6):587-8. PMID: 24901566.
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      62. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan K. Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30. PMID: 24882516.
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      63. Mo JS, Park HW, Guan K. The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep. 2014 Jun; 15(6):642-56. PMID: 24825474.
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      64. Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan K, Lei QY, Xiong Y. Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase. Cancer Res. 2014 Jul 1; 74(13):3630-42. PMID: 24786789.
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      65. Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan K, Ye D. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 2014 Jun 17; 33(12):1304-20. PMID: 24769394.
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      66. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan K, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt. Mol Cell. 2014 May 8; 54(3):378-91. PMID: 24703948.
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      149. Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan K. Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci U S A. 2009 Jun 2; 106(22):8923-8. PMID: 19458266.
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      150. Mori H, Inoki K, Masutani K, Wakabayashi Y, Komai K, Nakagawa R, Guan K, Yoshimura A. The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. Biochem Biophys Res Commun. 2009 Jul 10; 384(4):471-5. PMID: 19422788.
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      151. Inoki K, Guan K. Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet. 2009 Apr 15; 18(R1):R94-100. PMID: 19297407.
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      152. Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan K, Xiong Y. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009 Apr 10; 324(5924):261-5. PMID: 19359588.
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      153. Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG, Guan K. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab. 2009 Apr; 9(4):362-74. PMID: 19356717.
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      154. Kim E, Guan K. RAG GTPases in nutrient-mediated TOR signaling pathway. Cell Cycle. 2009 Apr 1; 8(7):1014-8. PMID: 19270521.
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      155. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan K. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009 May 15; 284(20):13355-62. PMID: 19324877.
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      156. Yu W, Lin Y, Yao J, Huang W, Lei Q, Xiong Y, Zhao S, Guan K. Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem. 2009 May 15; 284(20):13669-75. PMID: 19318352.
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      157. Zhao B, Lei QY, Guan K. Harness the power: new insights into the inhibition of YAP/Yorkie. Dev Cell. 2009 Mar; 16(3):321-2. PMID: 19289076.
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      158. Zhao B, Kim J, Ye X, Lai ZC, Guan K. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res. 2009 Feb 1; 69(3):1089-98. PMID: 19141641.
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      159. Zhao B, Lei QY, Guan K. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol. 2008 Dec; 20(6):638-46. PMID: 18955139.
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      160. Chen C, Liu Y, Liu R, Ikenoue T, Guan K, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 2008 Sep 29; 205(10):2397-408. PMID: 18809716.
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      161. Ikenoue T, Inoki K, Zhao B, Guan K. PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 2008 Sep 1; 68(17):6908-12. PMID: 18757404.
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      162. Buller CL, Loberg RD, Fan MH, Zhu Q, Park JL, Vesely E, Inoki K, Guan K, Brosius FC. A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C836-43. PMID: 18650261.
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      163. Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan K. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol. 2008 Aug; 10(8):935-45. PMID: 18604198.
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      164. Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang CY, Chinnaiyan AM, Lai ZC, Guan K. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008 Jul 15; 22(14):1962-71. PMID: 18579750.
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      165. Ikenoue T, Inoki K, Yang Q, Zhou X, Guan K. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23; 27(14):1919-31. PMID: 18566587.
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      166. Zhao S, Guan K. Substrate selectivity APPLies to Akt. Cell. 2008 May 2; 133(3):399-400. PMID: 18455980.
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      167. Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan K. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol. 2008 Apr; 28(7):2426-36. PMID: 18227151.
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      168. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan K. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007 Nov 1; 21(21):2747-61. PMID: 17974916.
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      169. Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan K. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 2007 Nov 28; 26(23):4812-23. PMID: 17962806.
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      170. Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, Guan K. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem. 2007 Dec 7; 282(49):35803-13. PMID: 17928295.
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      171. Yang Q, Guan K. Expanding mTOR signaling. Cell Res. 2007 Aug; 17(8):666-81. PMID: 17680028.
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      172. Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan K, Dong LQ, Liu F. Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem. 2007 Mar 16; 282(11):7991-6. PMID: 17244624.
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      173. Lee CH, Inoki K, Guan K. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol. 2007; 47:443-67. PMID: 16968213.
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      174. Yang Q, Inoki K, Ikenoue T, Guan K. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15; 20(20):2820-32. PMID: 17043309.
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      175. Wan M, Wu X, Guan K, Han M, Zhuang Y, Xu T. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett. 2006 Oct 16; 580(24):5621-7. PMID: 16996505.
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      176. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan K. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006 Sep 8; 126(5):955-68. PMID: 16959574.
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      177. Yang Q, Inoki K, Kim E, Guan K. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A. 2006 May 2; 103(18):6811-6. PMID: 16627617.
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      178. Inoki K, Guan K. Complexity of the TOR signaling network. Trends Cell Biol. 2006 Apr; 16(4):206-12. PMID: 16516475.
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      179. Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan K. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem. 2006 Mar 31; 281(13):8313-6. PMID: 16464865.
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      180. Li Y, Inoki K, Vikis H, Guan K. Measurements of TSC2 GAP activity toward Rheb. Methods Enzymol. 2006; 407:46-54. PMID: 16757313.
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      181. Gan B, Melkoumian ZK, Wu X, Guan K, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol. 2005 Aug 1; 170(3):379-89. PMID: 16043512.
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      182. Inoki K, Ouyang H, Li Y, Guan K. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev. 2005 Mar; 69(1):79-100. PMID: 15755954.
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      183. Yu Y, Li S, Xu X, Li Y, Guan K, Arnold E, Ding J. Structural basis for the unique biological function of small GTPase RHEB. J Biol Chem. 2005 Apr 29; 280(17):17093-100. PMID: 15728574.
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      184. Corradetti MN, Inoki K, Guan K. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18; 280(11):9769-72. PMID: 15632201.
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      185. Inoki K, Corradetti MN, Guan K. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005 Jan; 37(1):19-24. PMID: 15624019.
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      186. Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan K. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci. 2004 Nov; 7(11):1213-21. PMID: 15494734.
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      187. Li Y, Inoki K, Guan K. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol. 2004 Sep; 24(18):7965-75. PMID: 15340059.
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      188. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan K. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2004 Jul 1; 18(13):1533-8. PMID: 15231735.
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      189. Li W, Zhu T, Guan K. Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. J Biol Chem. 2004 Sep 3; 279(36):37398-406. PMID: 15210703.
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      190. Li Y, Corradetti MN, Inoki K, Guan K. TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem Sci. 2004 Jan; 29(1):32-8. PMID: 14729330.
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      191. Inoki K, Zhu T, Guan K. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003 Nov 26; 115(5):577-90. PMID: 14651849.
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      192. Inoki K, Li Y, Xu T, Guan K. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003 Aug 1; 17(15):1829-34. PMID: 12869586.
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      193. Tang ED, Wang CY, Xiong Y, Guan K. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem. 2003 Sep 26; 278(39):37297-305. PMID: 12867425.
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      194. Yang F, Tang E, Guan K, Wang CY. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol. 2003 Jun 1; 170(11):5630-5. PMID: 12759443.
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      195. Li Y, Inoki K, Vacratsis P, Guan K. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2003 Apr 18; 278(16):13663-71. PMID: 12582162.
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      196. Li Y, Inoki K, Yeung R, Guan K. Regulation of TSC2 by 14-3-3 binding. J Biol Chem. 2002 Nov 22; 277(47):44593-6. PMID: 12364343.
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      197. Inoki K, Li Y, Zhu T, Wu J, Guan K. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002 Sep; 4(9):648-57. PMID: 12172553.
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      198. You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan K, MacDougald OA, Brown AM, Evan G, Kitajewski J, Wang CY. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol. 2002 Apr 29; 157(3):429-40. PMID: 11980918.
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