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Kun-Liang Guan

Title(s)Professor, Pharmacology
SchoolHealth Sciences
Phone858-822-7945
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Purdue University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanism and Therapy for Ocular Melanoma
    NIH/NCI R01CA217642Mar 14, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    The mTOR and Hippo pathway in cell growth and cancer
    NIH/NCI R35CA196878Aug 5, 2015 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of the Hippo pathway and its role in uveal melanoma
    NIH/NEI R01EY022611Sep 1, 2012 - Aug 31, 2016
    Role: Principal Investigator
    Regulation and function of the YAP transcription co-activator oncoprotein
    NIH/NCI R01CA132809Apr 8, 2008 - Feb 28, 2018
    Role: Principal Investigator
    Rag GTPases in mTOR regulation and physiological functions
    NIH/NCI R01CA108941Sep 3, 2004 - Jun 30, 2019
    Role: Principal Investigator
    S6K and mTOR as targets for tuberous sclerosis
    NIH/NCI R41CA101611Jul 1, 2003 - Jun 30, 2004
    Role: Principal Investigator
    Regulation of Ras and Rheb modification by GCN2
    NIH/NIGMS R01GM062694Jul 1, 2000 - Jun 30, 2012
    Role: Principal Investigator
    REGULATION OF PROTEIN TYROSINE PHOSPHORYLATION IN YEAST
    NIH/NIGMS R01GM055642May 1, 1997 - Apr 30, 2001
    Role: Principal Investigator
    Protein phosphorylation and growth factor function
    NIH/NIGMS R01GM051586Aug 1, 1994 - Nov 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, Yuan HX. ELP3 acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). Biochem J. 2019 Jul 24. PMID: 31341009.
      View in: PubMed
    2. Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019 May 21; 8. PMID: 31112131.
      View in: PubMed
    3. Li W, Zhu T, Guan KL. Withdrawal: Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. J Biol Chem. 2019 May 17; 294(20):8310. PMID: 31101660.
      View in: PubMed
    4. Peng JR, Guan KL, Hong DY, Lin XH, Yang HM, Zhu YX. A special issue to mark the 90th Anniversary of College of Life Sciences, Zhejiang University. J Zhejiang Univ Sci B. 2019 May; 20(5):371-372. PMID: 31090262.
      View in: PubMed
    5. Li Y, Inoki K, Vacratsis P, Guan KL. Correction: The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2019 Apr 12; 294(15):5807. PMID: 30979849.
      View in: PubMed
    6. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2019 Apr 12; 294(15):5808. PMID: 30979850.
      View in: PubMed
    7. Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL. Correction: The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFß-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2019 Apr 12; 294(15):5809. PMID: 30979851.
      View in: PubMed
    8. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2019 04 01; 33(7-8):477. PMID: 30936192.
      View in: PubMed
    9. Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell. 2019 Jun; 18(3):e12943. PMID: 30924297.
      View in: PubMed
    10. Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, Guan KL, Verma IM. BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7363-7370. PMID: 30918126.
      View in: PubMed
    11. Li W, Aurandt J, Jürgensen C, Rao Y, Guan KL. Retraction: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5 (doi: 10.1242/jcs.02697). J Cell Sci. 2019 02 19; 132(5). PMID: 30782981.
      View in: PubMed
    12. Zhang M, Wu J, Sun R, Tao X, Wang X, Kang Q, Wang H, Zhang L, Liu P, Zhang J, Xia Y, Zhao Y, Yang Y, Xiong Y, Guan KL, Zou Y, Ye D. SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress. PLoS One. 2019; 14(2):e0211796. PMID: 30759120.
      View in: PubMed
    13. Kim J, Guan KL. mTOR as a central hub of nutrient signalling and cell growth. Nat Cell Biol. 2019 01; 21(1):63-71. PMID: 30602761.
      View in: PubMed
    14. Chen R, Plouffe SW, Guan KL. Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag. Methods Mol Biol. 2019; 1893:281-287. PMID: 30565141.
      View in: PubMed
    15. Xu H, Xia YK, Li CJ, Zhang JY, Liu Y, Yi W, Qin ZY, Chen L, Shi ZF, Quan K, Yang ZX, Guan KL, Xiong Y, Ng HK, Ye D, Hua W, Mao Y. Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry. Lab Invest. 2019 Apr; 99(4):588-598. PMID: 30573870.
      View in: PubMed
    16. Ma S, Meng Z, Chen R, Guan KL. The Hippo Pathway: Biology and Pathophysiology. Annu Rev Biochem. 2018 Dec 19. PMID: 30566373.
      View in: PubMed
    17. Pan WW, Moroishi T, Koo JH, Guan KL. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019 04; 38(14):2595-2610. PMID: 30531839.
      View in: PubMed
    18. Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Mol Cell. 2019 Jan 03; 73(1):7-21.e7. PMID: 30472188.
      View in: PubMed
    19. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. Cell Rep. 2018 Nov 06; 25(6):1680. PMID: 30404018.
      View in: PubMed
    20. Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL. SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Rep. 2018 Nov 06; 25(6):1485-1500.e4. PMID: 30404004.
      View in: PubMed
    21. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. Cell Rep. 2018 Oct 23; 25(4):1018-1026.e4. PMID: 30355481.
      View in: PubMed
    22. Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R, Wang W. Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell. 2018 Oct 18; 72(2):328-340.e8. PMID: 30293781.
      View in: PubMed
    23. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. Author Correction: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2018 Sep; 20(9):1098. PMID: 30018319.
      View in: PubMed
    24. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660. PMID: 30135582.
      View in: PubMed
    25. Koo JH, Guan KL. Interplay between YAP/TAZ and Metabolism. Cell Metab. 2018 Aug 07; 28(2):196-206. PMID: 30089241.
      View in: PubMed
    26. Akgül S, Li Y, Zheng S, Kool M, Treisman DM, Li C, Wang Y, Gröbner S, Ikenoue T, Shen Y, Camelo-Piragua S, Tomasek G, Stark S, Guduguntla V, Gusella JF, Guan KL, Pfister SM, Verhaak RGW, Zhu Y. Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma. Cell Rep. 2018 Jul 10; 24(2):463-478.e5. PMID: 29996106.
      View in: PubMed
    27. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 07 09; 9(1):2372. PMID: 29985391.
      View in: PubMed
    28. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. PMID: 29887596.
      View in: PubMed
    29. Ma S, Guan KL. Polycystic kidney disease: a Hippo connection. Genes Dev. 2018 06 01; 32(11-12):737-739. PMID: 29921661.
      View in: PubMed
    30. Plouffe SW, Lin KC, Moore JL, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL. The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell. J Biol Chem. 2018 07 13; 293(28):11230-11240. PMID: 29802201.
      View in: PubMed
    31. Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep. 2018 05; 19(5). PMID: 29491006.
      View in: PubMed
    32. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018 02 06; 9(1):508. PMID: 29410405.
      View in: PubMed
    33. Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 Mar 01; 128(3):970-984. PMID: 29400695.
      View in: PubMed
    34. Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH, Yuan HX, Xiong Y. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene. 2018 03; 37(12):1637-1653. PMID: 29335519.
      View in: PubMed
    35. Fu V, Plouffe SW, Guan KL. The Hippo pathway in organ development, homeostasis, and regeneration. Curr Opin Cell Biol. 2017 12; 49:99-107. PMID: 29316535.
      View in: PubMed
    36. Ye D, Guan KL, Xiong Y. Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates. Trends Cancer. 2018 02; 4(2):151-165. PMID: 29458964.
      View in: PubMed
    37. Chen R, Guan KL. Colonic epithelium rejuvenation through YAP/TAZ. EMBO J. 2018 01 17; 37(2):164-166. PMID: 29282206.
      View in: PubMed
    38. Cosset É, Ilmjärv S, Dutoit V, Elliott K, von Schalscha T, Camargo MF, Reiss A, Moroishi T, Seguin L, Gomez G, Moo JS, Preynat-Seauve O, Krause KH, Chneiweiss H, Sarkaria JN, Guan KL, Dietrich PY, Weis SM, Mischel PS, Cheresh DA. Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):856-868.e5. PMID: 29198914.
      View in: PubMed
    39. Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, Yuan HX. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017 11; 284(21):3619-3636. PMID: 28886238.
      View in: PubMed
    40. Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 05; 68(1):198-209.e6. PMID: 28985504.
      View in: PubMed
    41. Lin KC, Park HW, Guan KL. Regulation of the Hippo Pathway Transcription Factor TEAD. Trends Biochem Sci. 2017 11; 42(11):862-872. PMID: 28964625.
      View in: PubMed
    42. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002. PMID: 28752853.
      View in: PubMed
    43. Hong AW, Guan KL. Non-radioactive LATS in vitro Kinase Assay. Bio Protoc. 2017 Jul 20; 7(14). PMID: 29104896.
      View in: PubMed
    44. Jin Y, Chen Y, Zhao S, Guan KL, Zhuang Y, Zhou W, Wu X, Xu T. DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7408-7413. PMID: 28645898.
      View in: PubMed
    45. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. PMID: 28648777.
      View in: PubMed
    46. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635. PMID: 28417999.
      View in: PubMed
    47. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 04 15; 77(8):1997-2007. PMID: 28381547.
      View in: PubMed
    48. Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017 04 15; 37(8). PMID: 28137912.
      View in: PubMed
    49. Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan KL, Xu P. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 04; 19(4):362-374. PMID: 28346439.
      View in: PubMed
    50. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan KL. Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Res. 2017 05 01; 77(9):2413-2423. PMID: 28249901.
      View in: PubMed
    51. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648. PMID: 28130546.
      View in: PubMed
    52. Ma X, Zhang S, He L, Rong Y, Brier LW, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan KL, Li D, Zhong Q. MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 2017 Mar 04; 13(3):592-607. PMID: 28059666.
      View in: PubMed
    53. Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep. 2017 01; 18(1):72-86. PMID: 27979971.
      View in: PubMed
    54. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. PMID: 27912060.
      View in: PubMed
    55. Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV, Guan KL. Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell. 2016 12 01; 64(5):993-1008. PMID: 27912098.
      View in: PubMed
    56. Lin HP, Cheng ZL, He RY, Song L, Tian MX, Zhou LS, Groh BS, Liu WR, Ji MB, Ding C, Shi YH, Guan KL, Ye D, Xiong Y. Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. Cancer Res. 2016 12 01; 76(23):6924-6936. PMID: 27758890.
      View in: PubMed
    57. Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YJ, Chien S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11525-11530. PMID: 27671657.
      View in: PubMed
    58. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng Z, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan KL. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 09 02; 291(36):18947-58. PMID: 27382053; PMCID: PMC5009267 [Available on 09/02/17].
      View in: PubMed, PubMed Central
    59. Hong AW, Meng Z, Guan KL. The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol. 2016 06; 13(6):324-37. PMID: 27147489.
      View in: PubMed
    60. Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XH, Guan KL, Zou J, Xu P. Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes Dev. 2016 05 01; 30(9):1086-100. PMID: 27125670; PMCID: PMC4863739 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    61. Zha Z, Han XR, Smith MD, Lei QY, Guan KL, Xiong Y. Hypertension-associated C825T polymorphism impairs the function of Gß3 to target GRK2 ubiquitination. Cell Discov. 2016; 2:16005. PMID: 27462452; PMCID: PMC4849471.
      View in: PubMed, PubMed Central
    62. Fu V, Moroishi T, Guan KL. Glycoholics Anonymous: Cancer Sobers Up with mTORC1. Cancer Cell. 2016 Apr 11; 29(4):432-434. PMID: 27070696.
      View in: PubMed
    63. Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan KL, Yang P, Yu H, Ye D. SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Rep. 2016 06; 17(6):811-22. PMID: 27113762.
      View in: PubMed
    64. Diao Y, Li B, Meng Z, Jung I, Lee AY, Dixon J, Maliskova L, Guan KL, Shen Y, Ren B. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 2016 Mar; 26(3):397-405. PMID: 26813977; PMCID: PMC4772021.
      View in: PubMed, PubMed Central
    65. Yuan HX, Guan KL. Structural insights of mTOR complex 1. Cell Res. 2016 Mar; 26(3):267-8. PMID: 26794870; PMCID: PMC4783463 [Available on 03/01/17].
      View in: PubMed, PubMed Central
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    205. Mori H, Inoki K, Opland D, Münzberg H, Villanueva EC, Faouzi M, Ikenoue T, Kwiatkowski DJ, Macdougald OA, Myers MG, Guan KL. Critical roles for the TSC-mTOR pathway in ß-cell function. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1013-22. PMID: 19690069.
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    206. Chang J, Wang Z, Tang E, Fan Z, McCauley L, Franceschi R, Guan K, Krebsbach PH, Wang CY. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med. 2009 Jun; 15(6):682-9. PMID: 19448637; PMCID: PMC2768554.
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    207. Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL. Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8923-8. PMID: 19458266; PMCID: PMC2690031.
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    208. Mori H, Inoki K, Masutani K, Wakabayashi Y, Komai K, Nakagawa R, Guan KL, Yoshimura A. The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. Biochem Biophys Res Commun. 2009 Jul 10; 384(4):471-5. PMID: 19422788.
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    209. Inoki K, Guan KL. Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet. 2009 Apr 15; 18(R1):R94-100. PMID: 19297407; PMCID: PMC2657945.
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    210. Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009 Apr 10; 324(5924):261-5. PMID: 19359588; PMCID: PMC3251015.
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    211. Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG, Guan KL. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab. 2009 Apr; 9(4):362-74. PMID: 19356717; PMCID: PMC2790375.
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    212. Kim E, Guan KL. RAG GTPases in nutrient-mediated TOR signaling pathway. Cell Cycle. 2009 Apr 01; 8(7):1014-8. PMID: 19270521.
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    213. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009 May 15; 284(20):13355-62. PMID: 19324877; PMCID: PMC2679435.
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    214. Yu W, Lin Y, Yao J, Huang W, Lei Q, Xiong Y, Zhao S, Guan KL. Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem. 2009 May 15; 284(20):13669-75. PMID: 19318352; PMCID: PMC2679468.
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    215. Zhao B, Lei QY, Guan KL. Harness the power: new insights into the inhibition of YAP/Yorkie. Dev Cell. 2009 Mar; 16(3):321-2. PMID: 19289076.
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    216. Wang W, Guan KL. AMP-activated protein kinase and cancer. Acta Physiol (Oxf). 2009 May; 196(1):55-63. PMID: 19243571.
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    217. Liu G, Li W, Wang L, Kar A, Guan KL, Rao Y, Wu JY. DSCAM functions as a netrin receptor in commissural axon pathfinding. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2951-6. PMID: 19196994; PMCID: PMC2650370.
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    218. Zhao B, Kim J, Ye X, Lai ZC, Guan KL. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res. 2009 Feb 01; 69(3):1089-98. PMID: 19141641.
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    219. Zhao B, Lei QY, Guan KL. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol. 2008 Dec; 20(6):638-46. PMID: 18955139; PMCID: PMC3296452.
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    220. Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 2008 Sep 29; 205(10):2397-408. PMID: 18809716; PMCID: PMC2556783.
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    221. Ikenoue T, Inoki K, Zhao B, Guan KL. PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 2008 Sep 01; 68(17):6908-12. PMID: 18757404.
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    222. Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan KL, Wan Y. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem. 2008 Oct 24; 283(43):28897-908. PMID: 18715874.
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    223. Buller CL, Loberg RD, Fan MH, Zhu Q, Park JL, Vesely E, Inoki K, Guan KL, Brosius FC. A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C836-43. PMID: 18650261; PMCID: PMC2544442.
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    224. Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol. 2008 Aug; 10(8):935-45. PMID: 18604198; PMCID: PMC2711503.
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    225. Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang CY, Chinnaiyan AM, Lai ZC, Guan KL. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008 Jul 15; 22(14):1962-71. PMID: 18579750.
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    226. Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23; 27(14):1919-31. PMID: 18566587; PMCID: PMC2486275.
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    227. Zhao S, Guan KL. Substrate selectivity APPLies to Akt. Cell. 2008 May 02; 133(3):399-400. PMID: 18455980.
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    228. Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol. 2008 Apr; 28(7):2426-36. PMID: 18227151; PMCID: PMC2268418.
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    229. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007 Nov 01; 21(21):2747-61. PMID: 17974916; PMCID: PMC2045129.
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    230. Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan KL. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 2007 Nov 28; 26(23):4812-23. PMID: 17962806; PMCID: PMC2099465.
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    231. Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, Guan KL. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem. 2007 Dec 07; 282(49):35803-13. PMID: 17928295.
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    232. Yang Q, Guan KL. Expanding mTOR signaling. Cell Res. 2007 Aug; 17(8):666-81. PMID: 17680028.
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    233. Liu G, Li W, Gao X, Li X, Jürgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan KL, Rao Y. p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci. 2007 Jan 24; 27(4):957-68. PMID: 17251438; PMCID: PMC2014516.
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    234. Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan KL, Dong LQ, Liu F. Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem. 2007 Mar 16; 282(11):7991-6. PMID: 17244624.
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    235. Lee CH, Inoki K, Guan KL. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol. 2007; 47:443-67. PMID: 16968213.
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    236. Yang Q, Inoki K, Ikenoue T, Guan KL. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15; 20(20):2820-32. PMID: 17043309; PMCID: PMC1619946.
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    237. Wan M, Wu X, Guan KL, Han M, Zhuang Y, Xu T. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett. 2006 Oct 16; 580(24):5621-7. PMID: 16996505.
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    238. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006 Sep 08; 126(5):955-68. PMID: 16959574.
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    239. Yang Q, Inoki K, Kim E, Guan KL. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6811-6. PMID: 16627617; PMCID: PMC1458976.
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    240. Inoki K, Guan KL. Complexity of the TOR signaling network. Trends Cell Biol. 2006 Apr; 16(4):206-12. PMID: 16516475.
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    241. Aurandt J, Li W, Guan KL. Semaphorin 4D activates the MAPK pathway downstream of plexin-B1. Biochem J. 2006 Mar 01; 394(Pt 2):459-64. PMID: 16187944; PMCID: PMC1408676.
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    242. Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan KL. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem. 2006 Mar 31; 281(13):8313-6. PMID: 16464865.
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    243. Li Y, Inoki K, Vikis H, Guan KL. Measurements of TSC2 GAP activity toward Rheb. Methods Enzymol. 2006; 407:46-54. PMID: 16757313.
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    244. Li W, Aurandt J, Jürgensen C, Jürgense C, Rao Y, Guan KL. FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. J Cell Sci. 2006 Jan 01; 119(Pt 1):47-55. PMID: 16371650.
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    245. Kruger RP, Aurandt J, Guan KL. Semaphorins command cells to move. Nat Rev Mol Cell Biol. 2005 Oct; 6(10):789-800. PMID: 16314868.
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    246. Lee J, Li W, Guan KL. SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans. Mol Cell Biol. 2005 Aug; 25(15):6485-95. PMID: 16024786; PMCID: PMC1190325.
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    247. Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol. 2005 Aug 01; 170(3):379-89. PMID: 16043512; PMCID: PMC2171462.
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    248. Inoki K, Ouyang H, Li Y, Guan KL. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev. 2005 Mar; 69(1):79-100. PMID: 15755954; PMCID: PMC1082789.
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    249. Yu Y, Li S, Xu X, Li Y, Guan K, Arnold E, Ding J. Structural basis for the unique biological function of small GTPase RHEB. J Biol Chem. 2005 Apr 29; 280(17):17093-100. PMID: 15728574.
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    250. Corradetti MN, Inoki K, Guan KL. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18; 280(11):9769-72. PMID: 15632201.
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    251. Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005 Jan; 37(1):19-24. PMID: 15624019.
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    252. Kruger RP, Lee J, Li W, Guan KL. Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. J Neurosci. 2004 Dec 01; 24(48):10826-34. PMID: 15574733.
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    253. Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci. 2004 Nov; 7(11):1213-21. PMID: 15494734; PMCID: PMC2373267.
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    254. Li Y, Inoki K, Guan KL. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol. 2004 Sep; 24(18):7965-75. PMID: 15340059; PMCID: PMC515062.
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    255. Basile JR, Barac A, Zhu T, Guan KL, Gutkind JS. Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res. 2004 Aug 01; 64(15):5212-24. PMID: 15289326.
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    256. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2004 Jul 01; 18(13):1533-8. PMID: 15231735; PMCID: PMC443516.
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    257. Li W, Zhu T, Guan KL. Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. J Biol Chem. 2004 Sep 03; 279(36):37398-406. PMID: 15210703.
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    258. Li W, Guan KL. The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. J Biol Chem. 2004 Jul 30; 279(31):32824-31. PMID: 15169762.
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    259. Xie S, Wang Q, Ruan Q, Liu T, Jhanwar-Uniyal M, Guan K, Dai W. MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3. Oncogene. 2004 May 06; 23(21):3822-9. PMID: 15021912.
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    260. Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Res. 2004 Mar 15; 64(6):1924-31. PMID: 15026325.
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    261. Ruan Q, Wang Q, Xie S, Fang Y, Darzynkiewicz Z, Guan K, Jhanwar-Uniyal M, Dai W. Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle. Exp Cell Res. 2004 Mar 10; 294(1):51-9. PMID: 14980500.
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    262. Yang F, Yamashita J, Tang E, Wang HL, Guan K, Wang CY. The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop. J Immunol. 2004 Feb 15; 172(4):2446-52. PMID: 14764716.
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    263. Li Y, Corradetti MN, Inoki K, Guan KL. TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem Sci. 2004 Jan; 29(1):32-8. PMID: 14729330.
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    264. Yoder JH, Chong H, Guan KL, Han M. Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J. 2004 Jan 14; 23(1):111-9. PMID: 14685271; PMCID: PMC1271663.
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    265. Guan KL, Rao Y. Signalling mechanisms mediating neuronal responses to guidance cues. Nat Rev Neurosci. 2003 Dec; 4(12):941-56. PMID: 14682358.
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    266. Zhou Q, Rammohan K, Lin S, Robinson N, Li O, Liu X, Bai XF, Yin L, Scarberry B, Du P, You M, Guan K, Zheng P, Liu Y. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15041-6. PMID: 14657362; PMCID: PMC299898.
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    267. Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003 Nov 26; 115(5):577-90. PMID: 14651849.
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    268. Lanigan TM, Liu A, Huang YZ, Mei L, Margolis B, Guan KL. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. FASEB J. 2003 Nov; 17(14):2048-60. PMID: 14597674.
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    269. Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL, You M. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12642-7. PMID: 14583591; PMCID: PMC240671.
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    270. Tang ED, Inohara N, Wang CY, Nuñez G, Guan KL. Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. J Biol Chem. 2003 Oct 03; 278(40):38566-70. PMID: 12890679.
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    271. Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003 Aug 01; 17(15):1829-34. PMID: 12869586; PMCID: PMC196227.
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    272. Tang ED, Wang CY, Xiong Y, Guan KL. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem. 2003 Sep 26; 278(39):37297-305. PMID: 12867425.
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    273. Chong H, Guan KL. Regulation of Raf through phosphorylation and N terminus-C terminus interaction. J Biol Chem. 2003 Sep 19; 278(38):36269-76. PMID: 12865432.
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    274. Yang F, Tang E, Guan K, Wang CY. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol. 2003 Jun 01; 170(11):5630-5. PMID: 12759443.
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    275. Chong H, Vikis HG, Guan KL. Mechanisms of regulating the Raf kinase family. Cell Signal. 2003 May; 15(5):463-9. PMID: 12639709.
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    276. Li Y, Inoki K, Vacratsis P, Guan KL. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2003 Apr 18; 278(16):13663-71. PMID: 12582162.
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    277. Li Y, Inoki K, Yeung R, Guan KL. Regulation of TSC2 by 14-3-3 binding. J Biol Chem. 2002 Nov 22; 277(47):44593-6. PMID: 12364343.
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    278. Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002 Sep; 4(9):648-57. PMID: 12172553.
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    279. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12085-90. PMID: 12196628; PMCID: PMC129402.
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    280. You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan KL, MacDougald OA, Brown AM, Evan G, Kitajewski J, Wang CY. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol. 2002 Apr 29; 157(3):429-40. PMID: 11980918; PMCID: PMC2173296.
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    281. Vikis HG, Stewart S, Guan KL. SmgGDS displays differential binding and exchange activity towards different Ras isoforms. Oncogene. 2002 Apr 04; 21(15):2425-32. PMID: 11948427.
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    282. Vikis HG, Li W, Guan KL. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes Dev. 2002 Apr 01; 16(7):836-45. PMID: 11937491; PMCID: PMC186329.
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    283. Vikis H, Guan KL. Regulation of the Ras-MAPK pathway at the level of Ras and Raf. Genet Eng (N Y). 2002; 24:49-66. PMID: 12416300.
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    284. Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. FASEB J. 2002 Jan; 16(1):90-2. PMID: 11709497.
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