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Kun-Liang Guan

Title(s)Professor, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-822-7945
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Purdue University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanism and Therapy for Ocular Melanoma
    NIH R01CA217642Mar 14, 2017 - Feb 28, 2023
    Role: Co-Principal Investigator
    The mTOR and Hippo pathway in cell growth and cancer
    NIH R35CA196878Aug 5, 2015 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of the Hippo pathway and its role in uveal melanoma
    NIH R01EY022611Sep 1, 2012 - Aug 31, 2016
    Role: Principal Investigator
    Regulation and function of the YAP transcription co-activator oncoprotein
    NIH R01CA132809Apr 8, 2008 - Feb 29, 2016
    Role: Principal Investigator
    Rag GTPases in mTOR regulation and physiological functions
    NIH R01CA108941Sep 3, 2004 - Nov 30, 2013
    Role: Principal Investigator
    S6K and mTOR as targets for tuberous sclerosis
    NIH R41CA101611Jul 1, 2003 - Jun 30, 2004
    Role: Principal Investigator
    Regulation of Ras and Rheb modification by GCN2
    NIH R01GM062694Jul 1, 2000 - Sep 30, 2007
    Role: Principal Investigator
    REGULATION OF PROTEIN TYROSINE PHOSPHORYLATION IN YEAST
    NIH R01GM055642May 1, 1997 - Apr 30, 2001
    Role: Principal Investigator
    Protein phosphorylation and growth factor function
    NIH R01GM051586Aug 1, 1994 - Nov 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hippo Signaling in Embryogenesis and Development. Trends Biochem Sci. 2021 01; 46(1):51-63. Wu Z, Guan KL. PMID: 32928629.
      View in: PubMed   Mentions:    Fields:    
    2. Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Protein Cell. 2020 Jul 18. Xia YK, Zeng YR, Zhang ML, Liu P, Liu F, Zhang H, He CX, Sun YP, Zhang JY, Zhang C, Song L, Ding C, Tang YJ, Yang Z, Yang C, Wang P, Guan KL, Xiong Y, Ye D. PMID: 32683582.
      View in: PubMed   Mentions: 1     Fields:    
    3. The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Rep. 2020 07 14; 32(2):107877. Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan KL, Xiong Y, Zhang M, Ye D. PMID: 32668244.
      View in: PubMed   Mentions:    Fields:    
    4. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. 2020 07; 19(7):480-494. Dey A, Varelas X, Guan KL. PMID: 32555376.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting ß-Catenin/BCL9 Interaction. Cell Rep. 2020 Jun 16; 31(11):107792. Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY. PMID: 32553156.
      View in: PubMed   Mentions:    Fields:    
    6. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. 2020 Aug 06; 27(2):224-237.e6. Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan KL, Malmberg KJ, Kaufman DS. PMID: 32531207.
      View in: PubMed   Mentions: 3     Fields:    
    7. Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis. Cell Stem Cell. 2020 05 07; 26(5):612-614. Fu V, Guan KL. PMID: 32386550.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability. Cancer Res. 2020 06 15; 80(12):2550-2563. Zhou Z, Zhou H, Ponzoni L, Luo A, Zhu R, He M, Huang Y, Guan KL, Bahar I, Liu Z, Wan Y. PMID: 32269044.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell Metab. 2020 May 05; 31(5):969-986.e7. Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I. PMID: 32259482.
      View in: PubMed   Mentions: 6     Fields:    
    10. YAP/TAZ phase separation for transcription. Nat Cell Biol. 2020 04; 22(4):357-358. Franklin JM, Guan KL. PMID: 32203419.
      View in: PubMed   Mentions: 1     Fields:    
    11. Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver Int. 2020 06; 40(6):1378-1394. Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, Guan KL, Xiong Y, Liu J, Yuan HX. PMID: 32145145.
      View in: PubMed   Mentions: 4     Fields:    
    12. Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Genes Dev. 2020 04 01; 34(7-8):511-525. Hong AW, Meng Z, Plouffe SW, Lin Z, Zhang M, Guan KL. PMID: 32115406.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Publisher Correction: STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat Cell Biol. 2020 Feb; 22(2):257. Chen R, Xie R, Meng Z, Ma S, Guan KL. PMID: 31896773.
      View in: PubMed   Mentions:    Fields:    
    14. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes Dev. 2020 01 01; 34(1-2):72-86. Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL. PMID: 31831627.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. Volume Adaptation Controls Stem Cell Mechanotransduction. ACS Appl Mater Interfaces. 2019 Dec 11; 11(49):45520-45530. Major LG, Holle AW, Young JL, Hepburn MS, Jeong K, Chin IL, Sanderson RW, Jeong JH, Aman ZM, Kennedy BF, Hwang Y, Han DW, Park HW, Guan KL, Spatz JP, Choi YS. PMID: 31714734.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat Cell Biol. 2019 12; 21(12):1565-1577. Chen R, Xie R, Meng Z, Ma S, Guan KL. PMID: 31792377.
      View in: PubMed   Mentions: 9     Fields:    
    17. Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation. Blood. 2019 11 14; 134(20):1730-1744. Stoner SA, Yan M, Liu KTH, Arimoto KI, Shima T, Wang HY, Johnson DT, Bejar R, Jamieson C, Guan KL, Zhang DE. PMID: 31434702.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 12 17; 51(6):1012-1027.e7. Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H. PMID: 31668641.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    19. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019 10 07; 10(10):755. Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, Yuan HX. PMID: 31591388.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. YAP and TAZ regulate cell volume. J Cell Biol. 2019 10 07; 218(10):3472-3488. Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S, Wirtz D, Petrie RJ, Guan KL, Sun SX. PMID: 31481532.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). Biochem J. 2019 08 15; 476(15):2239-2254. Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, Yuan HX. PMID: 31341009.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. The Hippo Pathway: Biology and Pathophysiology. Annu Rev Biochem. 2019 06 20; 88:577-604. Ma S, Meng Z, Chen R, Guan KL. PMID: 30566373.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    23. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019 05 21; 8. Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. PMID: 31112131.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    24. Withdrawal: Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. J Biol Chem. 2019 May 17; 294(20):8310. Li W, Zhu T, Guan KL. PMID: 31101660.
      View in: PubMed   Mentions:    Fields:    
    25. A special issue to mark the 90th Anniversary of College of Life Sciences, Zhejiang University. J Zhejiang Univ Sci B. 2019 May; 20(5):371-372. Peng JR, Guan KL, Hong DY, Lin XH, Yang HM, Zhu YX. PMID: 31090262.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Correction: The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2019 Apr 12; 294(15):5807. Li Y, Inoki K, Vacratsis P, Guan KL. PMID: 30979849.
      View in: PubMed   Mentions:    Fields:    
    27. Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2019 Apr 12; 294(15):5808. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 30979850.
      View in: PubMed   Mentions:    Fields:    
    28. Correction: The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFß-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2019 Apr 12; 294(15):5809. Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL. PMID: 30979851.
      View in: PubMed   Mentions:    Fields:    
    29. Correction: Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem. 2019 Apr 12; 294(15):5810. Li L, Guan KL. PMID: 30979852.
      View in: PubMed   Mentions:    Fields:    
    30. Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2019 04 01; 33(7-8):477. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. PMID: 30936192.
      View in: PubMed   Mentions:    Fields:    
    31. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell. 2019 06; 18(3):e12943. Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB. PMID: 30924297.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    32. BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7363-7370. Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, Guan KL, Verma IM. PMID: 30918126.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    33. Retraction: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5 (doi: 10.1242/jcs.02697). J Cell Sci. 2019 02 19; 132(5). Li W, Aurandt J, Jürgensen C, Rao Y, Guan KL. PMID: 30782981.
      View in: PubMed   Mentions:    Fields:    
    34. SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress. PLoS One. 2019; 14(2):e0211796. Zhang M, Wu J, Sun R, Tao X, Wang X, Kang Q, Wang H, Zhang L, Liu P, Zhang J, Xia Y, Zhao Y, Yang Y, Xiong Y, Guan KL, Zou Y, Ye D. PMID: 30759120.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    35. mTOR as a central hub of nutrient signalling and cell growth. Nat Cell Biol. 2019 01; 21(1):63-71. Kim J, Guan KL. PMID: 30602761.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    36. Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag. Methods Mol Biol. 2019; 1893:281-287. Chen R, Plouffe SW, Guan KL. PMID: 30565141.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    37. Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry. Lab Invest. 2019 04; 99(4):588-598. Xu H, Xia YK, Li CJ, Zhang JY, Liu Y, Yi W, Qin ZY, Chen L, Shi ZF, Quan K, Yang ZX, Guan KL, Xiong Y, Ng HK, Ye D, Hua W, Mao Y. PMID: 30573870.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019 04; 38(14):2595-2610. Pan WW, Moroishi T, Koo JH, Guan KL. PMID: 30531839.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    39. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Mol Cell. 2019 01 03; 73(1):7-21.e7. Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. PMID: 30472188.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    40. SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Rep. 2018 11 06; 25(6):1485-1500.e4. Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL. PMID: 30404004.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    41. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. Cell Rep. 2018 Nov 06; 25(6):1680. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30404018.
      View in: PubMed   Mentions: 3     Fields:    
    42. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. Cell Rep. 2018 10 23; 25(4):1018-1026.e4. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30355481.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    43. Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell. 2018 10 18; 72(2):328-340.e8. Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R, Wang W. PMID: 30293781.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    44. Author Correction: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2018 Sep; 20(9):1098. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. PMID: 30018319.
      View in: PubMed   Mentions:    Fields:    
    45. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. PMID: 30135582.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    46. Interplay between YAP/TAZ and Metabolism. Cell Metab. 2018 08 07; 28(2):196-206. Koo JH, Guan KL. PMID: 30089241.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    47. Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma. Cell Rep. 2018 07 10; 24(2):463-478.e5. Akgül S, Li Y, Zheng S, Kool M, Treisman DM, Li C, Wang Y, Gröbner S, Ikenoue T, Shen Y, Camelo-Piragua S, Tomasek G, Stark S, Guduguntla V, Gusella JF, Guan KL, Pfister SM, Verhaak RGW, Zhu Y. PMID: 29996106.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    48. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 07 09; 9(1):2372. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. PMID: 29985391.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    49. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    50. Polycystic kidney disease: a Hippo connection. Genes Dev. 2018 06 01; 32(11-12):737-739. Ma S, Guan KL. PMID: 29921661.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    51. The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell. J Biol Chem. 2018 07 13; 293(28):11230-11240. Plouffe SW, Lin KC, Moore JL, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL. PMID: 29802201.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    52. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. . 2018 05; 19(5). Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D. PMID: 29491006.
      View in: PubMed   Mentions:
    53. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018 02 06; 9(1):508. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX. PMID: 29410405.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    54. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene. 2018 03; 37(12):1637-1653. PMID: 29335519.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    55. The Hippo pathway in organ development, homeostasis, and regeneration. Curr Opin Cell Biol. 2017 12; 49:99-107. PMID: 29316535.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    56. Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates. Trends Cancer. 2018 02; 4(2):151-165. Ye D, Guan KL, Xiong Y. PMID: 29458964.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    57. Colonic epithelium rejuvenation through YAP/TAZ. EMBO J. 2018 01 17; 37(2):164-166. Chen R, Guan KL. PMID: 29282206.
      View in: PubMed   Mentions:    Fields:    
    58. Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):856-868.e5. Cosset É, Ilmjärv S, Dutoit V, Elliott K, von Schalscha T, Camargo MF, Reiss A, Moroishi T, Seguin L, Gomez G, Moo JS, Preynat-Seauve O, Krause KH, Chneiweiss H, Sarkaria JN, Guan KL, Dietrich PY, Weis SM, Mischel PS, Cheresh DA. PMID: 29198914.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    59. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017 11; 284(21):3619-3636. PMID: 28886238.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    60. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 05; 68(1):198-209.e6. Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL. PMID: 28985504.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    61. Regulation of the Hippo Pathway Transcription Factor TEAD. Trends Biochem Sci. 2017 11; 42(11):862-872. Lin KC, Park HW, Guan KL. PMID: 28964625.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    62. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002. PMID: 28752853.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    63. Non-radioactive LATS in vitro Kinase Assay. Bio Protoc. 2017 Jul 20; 7(14). Hong AW, Guan KL. PMID: 29104896.
      View in: PubMed   Mentions:
    64. DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7408-7413. Jin Y, Chen Y, Zhao S, Guan KL, Zhuang Y, Zhou W, Wu X, Xu T. PMID: 28645898.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    65. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. PMID: 28648777.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    66. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635. PMID: 28417999.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    67. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 04 15; 77(8):1997-2007. PMID: 28381547.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    68. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017 04 15; 37(8). PMID: 28137912.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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