Kun-Liang Guan
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Title(s) | Professor, Pharmacology |
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School | Health Sciences |
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Address | 9500 Gilman Drive #0695 La Jolla CA 92093
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Phone | 858-822-7945 |
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vCard | Download vCard |
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Biography Overview Research ORNG Applications Bibliographic
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Hippo Signaling in Embryogenesis and Development. Trends Biochem Sci. 2021 01; 46(1):51-63.
Wu Z, Guan KL. PMID: 32928629.
View in: PubMed Mentions: Fields:
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Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Protein Cell. 2020 Jul 18.
Xia YK, Zeng YR, Zhang ML, Liu P, Liu F, Zhang H, He CX, Sun YP, Zhang JY, Zhang C, Song L, Ding C, Tang YJ, Yang Z, Yang C, Wang P, Guan KL, Xiong Y, Ye D. PMID: 32683582.
View in: PubMed Mentions: 1 Fields:
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The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Rep. 2020 07 14; 32(2):107877.
Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan KL, Xiong Y, Zhang M, Ye D. PMID: 32668244.
View in: PubMed Mentions: Fields:
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Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. 2020 07; 19(7):480-494.
Dey A, Varelas X, Guan KL. PMID: 32555376.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting ß-Catenin/BCL9 Interaction. Cell Rep. 2020 Jun 16; 31(11):107792.
Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY. PMID: 32553156.
View in: PubMed Mentions: Fields:
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Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. 2020 Aug 06; 27(2):224-237.e6.
Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan KL, Malmberg KJ, Kaufman DS. PMID: 32531207.
View in: PubMed Mentions: 3 Fields:
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Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis. Cell Stem Cell. 2020 05 07; 26(5):612-614.
Fu V, Guan KL. PMID: 32386550.
View in: PubMed Mentions: Fields: Translation: Cells
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EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability. Cancer Res. 2020 06 15; 80(12):2550-2563.
Zhou Z, Zhou H, Ponzoni L, Luo A, Zhu R, He M, Huang Y, Guan KL, Bahar I, Liu Z, Wan Y. PMID: 32269044.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell Metab. 2020 May 05; 31(5):969-986.e7.
Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I. PMID: 32259482.
View in: PubMed Mentions: 6 Fields:
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YAP/TAZ phase separation for transcription. Nat Cell Biol. 2020 04; 22(4):357-358.
Franklin JM, Guan KL. PMID: 32203419.
View in: PubMed Mentions: 1 Fields:
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Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver Int. 2020 06; 40(6):1378-1394.
Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, Guan KL, Xiong Y, Liu J, Yuan HX. PMID: 32145145.
View in: PubMed Mentions: 4 Fields:
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Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Genes Dev. 2020 04 01; 34(7-8):511-525.
Hong AW, Meng Z, Plouffe SW, Lin Z, Zhang M, Guan KL. PMID: 32115406.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Publisher Correction: STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat Cell Biol. 2020 Feb; 22(2):257.
Chen R, Xie R, Meng Z, Ma S, Guan KL. PMID: 31896773.
View in: PubMed Mentions: Fields:
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Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes Dev. 2020 01 01; 34(1-2):72-86.
Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL. PMID: 31831627.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Volume Adaptation Controls Stem Cell Mechanotransduction. ACS Appl Mater Interfaces. 2019 Dec 11; 11(49):45520-45530.
Major LG, Holle AW, Young JL, Hepburn MS, Jeong K, Chin IL, Sanderson RW, Jeong JH, Aman ZM, Kennedy BF, Hwang Y, Han DW, Park HW, Guan KL, Spatz JP, Choi YS. PMID: 31714734.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat Cell Biol. 2019 12; 21(12):1565-1577.
Chen R, Xie R, Meng Z, Ma S, Guan KL. PMID: 31792377.
View in: PubMed Mentions: 9 Fields:
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Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation. Blood. 2019 11 14; 134(20):1730-1744.
Stoner SA, Yan M, Liu KTH, Arimoto KI, Shima T, Wang HY, Johnson DT, Bejar R, Jamieson C, Guan KL, Zhang DE. PMID: 31434702.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 12 17; 51(6):1012-1027.e7.
Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H. PMID: 31668641.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019 10 07; 10(10):755.
Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, Yuan HX. PMID: 31591388.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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YAP and TAZ regulate cell volume. J Cell Biol. 2019 10 07; 218(10):3472-3488.
Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S, Wirtz D, Petrie RJ, Guan KL, Sun SX. PMID: 31481532.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). Biochem J. 2019 08 15; 476(15):2239-2254.
Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, Yuan HX. PMID: 31341009.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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The Hippo Pathway: Biology and Pathophysiology. Annu Rev Biochem. 2019 06 20; 88:577-604.
Ma S, Meng Z, Chen R, Guan KL. PMID: 30566373.
View in: PubMed Mentions: 45 Fields: Translation: HumansAnimalsCells
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GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019 05 21; 8.
Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. PMID: 31112131.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Withdrawal: Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. J Biol Chem. 2019 May 17; 294(20):8310.
Li W, Zhu T, Guan KL. PMID: 31101660.
View in: PubMed Mentions: Fields:
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A special issue to mark the 90th Anniversary of College of Life Sciences, Zhejiang University. J Zhejiang Univ Sci B. 2019 May; 20(5):371-372.
Peng JR, Guan KL, Hong DY, Lin XH, Yang HM, Zhu YX. PMID: 31090262.
View in: PubMed Mentions: Fields: Translation: Humans
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Correction: The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2019 Apr 12; 294(15):5807.
Li Y, Inoki K, Vacratsis P, Guan KL. PMID: 30979849.
View in: PubMed Mentions: Fields:
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Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2019 Apr 12; 294(15):5808.
Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 30979850.
View in: PubMed Mentions: Fields:
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Correction: The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFß-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2019 Apr 12; 294(15):5809.
Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL. PMID: 30979851.
View in: PubMed Mentions: Fields:
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Correction: Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem. 2019 Apr 12; 294(15):5810.
Li L, Guan KL. PMID: 30979852.
View in: PubMed Mentions: Fields:
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Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2019 04 01; 33(7-8):477.
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. PMID: 30936192.
View in: PubMed Mentions: Fields:
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mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell. 2019 06; 18(3):e12943.
Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB. PMID: 30924297.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7363-7370.
Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, Guan KL, Verma IM. PMID: 30918126.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Retraction: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5 (doi: 10.1242/jcs.02697). J Cell Sci. 2019 02 19; 132(5).
Li W, Aurandt J, Jürgensen C, Rao Y, Guan KL. PMID: 30782981.
View in: PubMed Mentions: Fields:
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SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress. PLoS One. 2019; 14(2):e0211796.
Zhang M, Wu J, Sun R, Tao X, Wang X, Kang Q, Wang H, Zhang L, Liu P, Zhang J, Xia Y, Zhao Y, Yang Y, Xiong Y, Guan KL, Zou Y, Ye D. PMID: 30759120.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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mTOR as a central hub of nutrient signalling and cell growth. Nat Cell Biol. 2019 01; 21(1):63-71.
Kim J, Guan KL. PMID: 30602761.
View in: PubMed Mentions: 104 Fields: Translation: HumansAnimalsCells
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Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag. Methods Mol Biol. 2019; 1893:281-287.
Chen R, Plouffe SW, Guan KL. PMID: 30565141.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry. Lab Invest. 2019 04; 99(4):588-598.
Xu H, Xia YK, Li CJ, Zhang JY, Liu Y, Yi W, Qin ZY, Chen L, Shi ZF, Quan K, Yang ZX, Guan KL, Xiong Y, Ng HK, Ye D, Hua W, Mao Y. PMID: 30573870.
View in: PubMed Mentions: Fields: Translation: Humans
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Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019 04; 38(14):2595-2610.
Pan WW, Moroishi T, Koo JH, Guan KL. PMID: 30531839.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Mol Cell. 2019 01 03; 73(1):7-21.e7.
Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. PMID: 30472188.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Rep. 2018 11 06; 25(6):1485-1500.e4.
Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL. PMID: 30404004.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. Cell Rep. 2018 Nov 06; 25(6):1680.
Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30404018.
View in: PubMed Mentions: 3 Fields:
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Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. Cell Rep. 2018 10 23; 25(4):1018-1026.e4.
Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30355481.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell. 2018 10 18; 72(2):328-340.e8.
Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R, Wang W. PMID: 30293781.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Author Correction: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2018 Sep; 20(9):1098.
Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. PMID: 30018319.
View in: PubMed Mentions: Fields:
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RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660.
Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. PMID: 30135582.
View in: PubMed Mentions: 39 Fields: Translation: HumansAnimalsCells
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Interplay between YAP/TAZ and Metabolism. Cell Metab. 2018 08 07; 28(2):196-206.
Koo JH, Guan KL. PMID: 30089241.
View in: PubMed Mentions: 34 Fields: Translation: HumansAnimalsCells
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Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma. Cell Rep. 2018 07 10; 24(2):463-478.e5.
Akgül S, Li Y, Zheng S, Kool M, Treisman DM, Li C, Wang Y, Gröbner S, Ikenoue T, Shen Y, Camelo-Piragua S, Tomasek G, Stark S, Guduguntla V, Gusella JF, Guan KL, Pfister SM, Verhaak RGW, Zhu Y. PMID: 29996106.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 07 09; 9(1):2372.
Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. PMID: 29985391.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507.
Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimals
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Polycystic kidney disease: a Hippo connection. Genes Dev. 2018 06 01; 32(11-12):737-739.
Ma S, Guan KL. PMID: 29921661.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell. J Biol Chem. 2018 07 13; 293(28):11230-11240.
Plouffe SW, Lin KC, Moore JL, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL. PMID: 29802201.
View in: PubMed Mentions: 34 Fields: Translation: HumansCells
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SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. . 2018 05; 19(5).
Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D. PMID: 29491006.
View in: PubMed Mentions:
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Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018 02 06; 9(1):508.
Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX. PMID: 29410405.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene. 2018 03; 37(12):1637-1653.
PMID: 29335519.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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The Hippo pathway in organ development, homeostasis, and regeneration. Curr Opin Cell Biol. 2017 12; 49:99-107.
PMID: 29316535.
View in: PubMed Mentions: 32 Fields: Translation: Humans
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Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates. Trends Cancer. 2018 02; 4(2):151-165.
Ye D, Guan KL, Xiong Y. PMID: 29458964.
View in: PubMed Mentions: 36 Fields: Translation: HumansAnimals
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Colonic epithelium rejuvenation through YAP/TAZ. EMBO J. 2018 01 17; 37(2):164-166.
Chen R, Guan KL. PMID: 29282206.
View in: PubMed Mentions: Fields:
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Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):856-868.e5.
Cosset É, Ilmjärv S, Dutoit V, Elliott K, von Schalscha T, Camargo MF, Reiss A, Moroishi T, Seguin L, Gomez G, Moo JS, Preynat-Seauve O, Krause KH, Chneiweiss H, Sarkaria JN, Guan KL, Dietrich PY, Weis SM, Mischel PS, Cheresh DA. PMID: 29198914.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017 11; 284(21):3619-3636.
PMID: 28886238.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 05; 68(1):198-209.e6.
Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL. PMID: 28985504.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Regulation of the Hippo Pathway Transcription Factor TEAD. Trends Biochem Sci. 2017 11; 42(11):862-872.
Lin KC, Park HW, Guan KL. PMID: 28964625.
View in: PubMed Mentions: 36 Fields: Translation: HumansAnimalsCells
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Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002.
PMID: 28752853.
View in: PubMed Mentions: 38 Fields: Translation: HumansAnimalsCells
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Non-radioactive LATS in vitro Kinase Assay. Bio Protoc. 2017 Jul 20; 7(14).
Hong AW, Guan KL. PMID: 29104896.
View in: PubMed Mentions:
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DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7408-7413.
Jin Y, Chen Y, Zhao S, Guan KL, Zhuang Y, Zhou W, Wu X, Xu T. PMID: 28645898.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7.
PMID: 28648777.
View in: PubMed Mentions: 31 Fields: Translation: HumansCells
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A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635.
PMID: 28417999.
View in: PubMed Mentions: 48 Fields: Translation: HumansCells
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eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 04 15; 77(8):1997-2007.
PMID: 28381547.
View in: PubMed Mentions: 22 Fields: Translation: HumansCells
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L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017 04 15; 37(8).
PMID: 28137912.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 04; 19(4):362-374.
Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan KL, Xu P. PMID: 28346439.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Res. 2017 05 01; 77(9):2413-2423.
PMID: 28249901.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648.
PMID: 28130546.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimalsCells
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MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 2017 Mar 04; 13(3):592-607.
PMID: 28059666.
View in: PubMed Mentions: 17 Fields: Translation: AnimalsCells
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Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep. 2017 01; 18(1):72-86.
PMID: 27979971.
View in: PubMed Mentions:
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The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17.
PMID: 27912060.
View in: PubMed Mentions: 84 Fields: Translation: AnimalsCells
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Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell. 2016 12 01; 64(5):993-1008.
PMID: 27912098.
View in: PubMed Mentions: 48 Fields: Translation: HumansCells
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Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. Cancer Res. 2016 12 01; 76(23):6924-6936.
PMID: 27758890.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11525-11530.
PMID: 27671657.
View in: PubMed Mentions: 62 Fields: Translation: HumansAnimalsCells
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Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 09 02; 291(36):18947-58.
PMID: 27382053.
View in: PubMed Mentions: 21 Fields: Translation: HumansCells
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The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol. 2016 06; 13(6):324-37.
PMID: 27147489.
View in: PubMed Mentions: 47 Fields: Translation: HumansAnimalsCells
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Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes Dev. 2016 05 01; 30(9):1086-100.
PMID: 27125670.
View in: PubMed Mentions: 22 Fields: Translation: HumansAnimalsCells
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Hypertension-associated C825T polymorphism impairs the function of Gß3 to target GRK2 ubiquitination. Cell Discov. 2016; 2:16005.
PMID: 27462452.
View in: PubMed Mentions:
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Glycoholics Anonymous: Cancer Sobers Up with mTORC1. Cancer Cell. 2016 Apr 11; 29(4):432-434.
PMID: 27070696.
View in: PubMed Mentions: Fields: Translation: HumansCells
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SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Rep. 2016 06; 17(6):811-22.
PMID: 27113762.
View in: PubMed Mentions:
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A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 2016 Mar; 26(3):397-405.
PMID: 26813977.
View in: PubMed Mentions: 35 Fields: Translation: HumansCells
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Structural insights of mTOR complex 1. Cell Res. 2016 Mar; 26(3):267-8.
PMID: 26794870.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
PMID: 26799652.
View in: PubMed Mentions: 1606 Fields: Translation: HumansAnimals
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Mechanisms of Hippo pathway regulation. Genes Dev. 2016 Jan 01; 30(1):1-17.
PMID: 26728553.
View in: PubMed Mentions: 316 Fields: Translation: HumansAnimalsCells
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Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22; 13(11):2353-2361.
PMID: 26686626.
View in: PubMed Mentions: 39 Fields: Translation: HumansCells
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The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Res. 2015 Dec; 25(12):1299-313.
PMID: 26611634.
View in: PubMed Mentions: 49 Fields: Translation: HumansCells
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NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev. 2015 Nov 15; 29(22):2362-76.
PMID: 26588989.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 2015 Nov 05; 163(4):811-28.
PMID: 26544935.
View in: PubMed Mentions: 465 Fields: Translation: HumansAnimalsCells
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Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015 Nov; 13(11):e1002287.
PMID: 26539968.
View in: PubMed Mentions: 2 Fields:
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The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015 Nov; 5(11):1127-9.
PMID: 26526694.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nat Cell Biol. 2015 Nov; 17(11):1379-87.
PMID: 26502054.
View in: PubMed Mentions: 43 Fields: Translation: AnimalsCells
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MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015 Oct 05; 6:8357.
PMID: 26437443.
View in: PubMed Mentions: 117 Fields: Translation: HumansAnimalsCells
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Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015 Sep 21; 6:8283.
PMID: 26387534.
View in: PubMed Mentions: 15 Fields: Translation: HumansAnimalsCells
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Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Sep 21; 5:14029.
PMID: 26390293.
View in: PubMed Mentions: 3 Fields:
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Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015; 13(9):e1002243.
PMID: 26356530.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimalsCells
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AMPK and autophagy in glucose/glycogen metabolism. Mol Aspects Med. 2015 Dec; 46:46-62.
PMID: 26297963.
View in: PubMed Mentions: 35 Fields: Translation: HumansAnimals
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Alternative Wnt Signaling Activates YAP/TAZ. Cell. 2015 Aug 13; 162(4):780-94.
PMID: 26276632.
View in: PubMed Mentions: 149 Fields: Translation: HumansAnimalsCells
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Hippo pathway regulation of gastrointestinal tissues. Annu Rev Physiol. 2015; 77:201-27.
PMID: 25293527.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
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An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development. 2011 Aug; 138(16):3343-56.
PMID: 21791526.
View in: PubMed Mentions: 49 Fields: Translation: HumansAnimalsCells
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Amino acid signaling in TOR activation. Annu Rev Biochem. 2011; 80:1001-32.
PMID: 21548787.
View in: PubMed Mentions: 89 Fields: Translation: HumansAnimalsCells
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Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc. 2010 Sep; 5(9):1583-95.
Guan KL, Yu W, Lin Y, Xiong Y, Zhao S. PMID: 21085124.
View in: PubMed Mentions: 34 Fields: Translation: HumansCells
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Critical roles for the TSC-mTOR pathway in ß-cell function. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1013-22.
Mori H, Inoki K, Opland D, Münzberg H, Villanueva EC, Faouzi M, Ikenoue T, Kwiatkowski DJ, Macdougald OA, Myers MG, Guan KL. PMID: 19690069.
View in: PubMed Mentions: 45 Fields: Translation: AnimalsCells
This graph shows the total number of publications by year. To see the data as text, click here.
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Year | Publications |
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2009 | 1 | 2010 | 1 | 2011 | 2 | 2014 | 1 | 2015 | 13 | 2016 | 15 | 2017 | 16 | 2018 | 20 | 2019 | 23 | 2020 | 13 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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