Kun-liang Guan

Title(s)Emeritus Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Purdue University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanism and Therapy for Ocular Melanoma
    NIH R01CA217642Mar 14, 2017 - Feb 28, 2023
    Role: Co-Principal Investigator
    The mTOR and Hippo pathway in cell growth and cancer
    NIH R35CA196878Aug 5, 2015 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of the Hippo pathway and its role in uveal melanoma
    NIH R01EY022611Sep 1, 2012 - Aug 31, 2016
    Role: Principal Investigator
    Regulation and function of the YAP transcription co-activator oncoprotein
    NIH R01CA132809Apr 8, 2008 - Feb 28, 2018
    Role: Principal Investigator
    Rag GTPases in mTOR regulation and physiological functions
    NIH R01CA108941Sep 3, 2004 - Jun 30, 2019
    Role: Principal Investigator
    S6K and mTOR as targets for tuberous sclerosis
    NIH R41CA101611Jul 1, 2003 - Jun 30, 2004
    Role: Principal Investigator
    Regulation of Ras and Rheb modification by GCN2
    NIH R01GM062694Jul 1, 2000 - Jun 30, 2012
    Role: Principal Investigator
    REGULATION OF PROTEIN TYROSINE PHOSPHORYLATION IN YEAST
    NIH R01GM055642May 1, 1997 - Apr 30, 2001
    Role: Principal Investigator
    Protein phosphorylation and growth factor function
    NIH R01GM051586Aug 1, 1994 - Jun 30, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rheb regulates nuclear mTORC1 activity independent of farnesylation. Cell Chem Biol. 2022 06 16; 29(6):1037-1045.e4. Zhong Y, Zhou X, Guan KL, Zhang J. PMID: 35294906; PMCID: PMC9667991.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    2. Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses. Nat Cell Biol. 2022 03; 24(3):353-363. Chen LL, Morcelle C, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M, Zhu Y, Zhou N, Cheng M, He C, Liu KY, Lu G, Zhang L, Zhang C, Zhang J, Sun Y, Qi T, Lyu Y, Ren ZZ, Tan XM, Yin J, Lan F, Liu Y, Yang H, Qian M, Duan C, Chang X, Zhou Y, Shen L, Baldwin AS, Guan KL, Xiong Y, Ye D. PMID: 35256775; PMCID: PMC9305987.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    3. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer. Nat Commun. 2022 02 25; 13(1):1061. Ma S, Tang T, Probst G, Konradi A, Jin C, Li F, Gutkind JS, Fu XD, Guan KL. PMID: 35217640; PMCID: PMC8881512.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    4. Rag GTPases regulate cellular amino acid homeostasis. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). Inoki K, Guan KL. PMID: 35177479; PMCID: PMC8872802.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence. Mol Oncol. 2022 02; 16(3):607-629. Yu L, Zhou D, Zhang G, Ren Z, Luo X, Liu P, Plouffe SW, Meng Z, Moroishi T, Li Y, Zhang Y, Brown JH, Liu S, Guan KL. PMID: 34706158; PMCID: PMC8807356.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    6. The two sides of Hippo pathway in cancer. Semin Cancer Biol. 2022 10; 85:33-42. Li FL, Guan KL. PMID: 34265423.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    7. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 06; 20(6):986-998. Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. PMID: 33850002.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    8. Hippo signalling maintains ER expression and ER+ breast cancer growth. Nature. 2021 03; 591(7848):E1-E10. Ma S, Wu Z, Yang F, Zhang J, Johnson RL, Rosenfeld MG, Guan KL. PMID: 33658690; PMCID: PMC8725601.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    9. Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells. Sci Adv. 2021 01; 7(5). Wang Y, Wu J, Chen H, Yang Y, Xiao C, Yi X, Shi C, Zhong K, He H, Li Y, Wu Z, Zhou G, Rao Q, Wang X, Zhou X, Lomberk G, Liu B, Zhao J, Ge J, Zhou W, Chu X, Chen C, Zhou X, Wang L, Guan K, Qu L. PMID: 33571129; PMCID: PMC7840125.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    10. Structural insights into TSC complex assembly and GAP activity on Rheb. Nat Commun. 2021 01 12; 12(1):339. Yang H, Yu Z, Chen X, Li J, Li N, Cheng J, Gao N, Yuan HX, Ye D, Guan KL, Xu Y. PMID: 33436626; PMCID: PMC7804450.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    11. Heat stress activates YAP/TAZ to induce the heat shock transcriptome. Nat Cell Biol. 2020 12; 22(12):1447-1459. Luo M, Meng Z, Moroishi T, Lin KC, Shen G, Mo F, Shao B, Wei X, Zhang P, Wei Y, Guan KL. PMID: 33199845; PMCID: PMC7757600.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    12. Hippo Signaling in Embryogenesis and Development. Trends Biochem Sci. 2021 01; 46(1):51-63. Wu Z, Guan KL. PMID: 32928629; PMCID: PMC7749079.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    13. A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. Cell Rep. 2020 09 08; 32(10):108118. Lin Z, Xie R, Guan K, Zhang M. PMID: 32905778; PMCID: PMC7494017.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. 2020 07; 19(7):480-494. Dey A, Varelas X, Guan KL. PMID: 32555376; PMCID: PMC7880238.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    15. LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction. Cell Rep. 2020 Jun 16; 31(11):107792. Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY. PMID: 32553156; PMCID: PMC7380863.
      View in: PubMed   Mentions: 1     Fields:    
    16. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. 2020 08 06; 27(2):224-237.e6. Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan KL, Malmberg KJ, Kaufman DS. PMID: 32531207; PMCID: PMC7415618.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    17. Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis. Cell Stem Cell. 2020 05 07; 26(5):612-614. Fu V, Guan KL. PMID: 32386550.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. YAP/TAZ phase separation for transcription. Nat Cell Biol. 2020 04; 22(4):357-358. Franklin JM, Guan KL. PMID: 32203419.
      View in: PubMed   Mentions: 13     Fields:    
    19. Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Genes Dev. 2020 04 01; 34(7-8):511-525. Hong AW, Meng Z, Plouffe SW, Lin Z, Zhang M, Guan KL. PMID: 32115406; PMCID: PMC7111263.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    20. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes Dev. 2020 01 01; 34(1-2):72-86. Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL. PMID: 31831627; PMCID: PMC6938666.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    21. STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat Cell Biol. 2019 12; 21(12):1565-1577. Chen R, Xie R, Meng Z, Ma S, Guan KL. PMID: 31792377.
      View in: PubMed   Mentions: 50     Fields:    
    22. Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation. Blood. 2019 11 14; 134(20):1730-1744. Stoner SA, Yan M, Liu KTH, Arimoto KI, Shima T, Wang HY, Johnson DT, Bejar R, Jamieson C, Guan KL, Zhang DE. PMID: 31434702; PMCID: PMC6856986.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    23. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 12 17; 51(6):1012-1027.e7. Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H. PMID: 31668641; PMCID: PMC6948188.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    24. Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity. Elife. 2019 09 05; 8. Lin Z, Yang Z, Xie R, Ji Z, Guan K, Zhang M. PMID: 31486770; PMCID: PMC6744271.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    25. YAP and TAZ regulate cell volume. J Cell Biol. 2019 10 07; 218(10):3472-3488. Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S, Wirtz D, Petrie RJ, Guan KL, Sun SX. PMID: 31481532; PMCID: PMC6781432.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    26. The Hippo Pathway: Biology and Pathophysiology. Annu Rev Biochem. 2019 06 20; 88:577-604. Ma S, Meng Z, Chen R, Guan KL. PMID: 30566373.
      View in: PubMed   Mentions: 341     Fields:    Translation:HumansAnimalsCells
    27. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019 05 21; 8. Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. PMID: 31112131; PMCID: PMC6529218.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    28. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell. 2019 06; 18(3):e12943. Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB. PMID: 30924297; PMCID: PMC6516169.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    29. BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7363-7370. Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, Guan KL, Verma IM. PMID: 30918126; PMCID: PMC6462108.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    30. mTOR as a central hub of nutrient signalling and cell growth. Nat Cell Biol. 2019 01; 21(1):63-71. Kim J, Guan KL. PMID: 30602761.
      View in: PubMed   Mentions: 360     Fields:    Translation:HumansAnimalsCells
    31. Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag. Methods Mol Biol. 2019; 1893:281-287. Chen R, Plouffe SW, Guan KL. PMID: 30565141.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019 04; 38(14):2595-2610. Pan WW, Moroishi T, Koo JH, Guan KL. PMID: 30531839; PMCID: PMC6450751.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    33. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Mol Cell. 2019 01 03; 73(1):7-21.e7. Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. PMID: 30472188.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    34. SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Rep. 2018 11 06; 25(6):1485-1500.e4. Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL. PMID: 30404004; PMCID: PMC6317994.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    35. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. Cell Rep. 2018 Nov 06; 25(6):1680. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30404018; PMCID: PMC7337229.
      View in: PubMed   Mentions: 10     Fields:    
    36. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. PMID: 30135582; PMCID: PMC6128698.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    37. Interplay between YAP/TAZ and Metabolism. Cell Metab. 2018 08 07; 28(2):196-206. Koo JH, Guan KL. PMID: 30089241.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    38. Polycystic kidney disease: a Hippo connection. Genes Dev. 2018 06 01; 32(11-12):737-739. Ma S, Guan KL. PMID: 29921661; PMCID: PMC6049516.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    39. The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell. J Biol Chem. 2018 07 13; 293(28):11230-11240. Plouffe SW, Lin KC, Moore JL, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL. PMID: 29802201; PMCID: PMC6052207.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    40. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep. 2018 05; 19(5). Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D. PMID: 29491006; PMCID: PMC5934778.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    41. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018 02 06; 9(1):508. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX. PMID: 29410405; PMCID: PMC5802808.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    42. The Hippo pathway in organ development, homeostasis, and regeneration. Curr Opin Cell Biol. 2017 12; 49:99-107. Fu V, Plouffe SW, Guan KL. PMID: 29316535; PMCID: PMC6348871.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    43. Colonic epithelium rejuvenation through YAP/TAZ. EMBO J. 2018 01 17; 37(2):164-166. Chen R, Guan KL. PMID: 29282206; PMCID: PMC5770785.
      View in: PubMed   Mentions: 3     Fields:    
    44. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 05; 68(1):198-209.e6. Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL. PMID: 28985504.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    45. Regulation of the Hippo Pathway Transcription Factor TEAD. Trends Biochem Sci. 2017 11; 42(11):862-872. Lin KC, Park HW, Guan KL. PMID: 28964625; PMCID: PMC5735856.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    46. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. PMID: 28752853; PMCID: PMC5541894.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    47. Non-radioactive LATS in vitro Kinase Assay. Bio Protoc. 2017 Jul 20; 7(14). Hong AW, Guan KL. PMID: 29104896; PMCID: PMC5669374.
      View in: PubMed   Mentions: 4  
    48. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. PMID: 28648777; PMCID: PMC5521991.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    49. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B. PMID: 28417999; PMCID: PMC5490986.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    50. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 04 15; 77(8):1997-2007. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL. PMID: 28381547; PMCID: PMC5392372.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    51. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017 04 15; 37(8). Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL. PMID: 28137912; PMCID: PMC5376639.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    52. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 04; 19(4):362-374. Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan KL, Xu P. PMID: 28346439; PMCID: PMC5398908.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    53. Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Res. 2017 05 01; 77(9):2413-2423. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan KL. PMID: 28249901; PMCID: PMC6724531.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    54. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep. 2017 01; 18(1):72-86. Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL. PMID: 27979971; PMCID: PMC5210094.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    55. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL. PMID: 27912060; PMCID: PMC5512418.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    56. Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell. 2016 12 01; 64(5):993-1008. Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV, Guan KL. PMID: 27912098; PMCID: PMC5137798.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    57. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 09 02; 291(36):18947-58. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng Z, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan KL. PMID: 27382053; PMCID: PMC5009267.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    58. The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol. 2016 06; 13(6):324-37. Hong AW, Meng Z, Guan KL. PMID: 27147489; PMCID: PMC5642988.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    59. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 2016 Mar; 26(3):397-405. Diao Y, Li B, Meng Z, Jung I, Lee AY, Dixon J, Maliskova L, Guan KL, Shen Y, Ren B. PMID: 26813977; PMCID: PMC4772021.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    60. Structural insights of mTOR complex 1. Cell Res. 2016 Mar; 26(3):267-8. Yuan HX, Guan KL. PMID: 26794870; PMCID: PMC4783463.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    61. Mechanisms of Hippo pathway regulation. Genes Dev. 2016 Jan 01; 30(1):1-17. Meng Z, Moroishi T, Guan KL. PMID: 26728553; PMCID: PMC4701972.
      View in: PubMed   Mentions: 682     Fields:    Translation:HumansAnimalsCells
    62. The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Res. 2015 Dec; 25(12):1299-313. Hansen CG, Ng YL, Lam WL, Plouffe SW, Guan KL. PMID: 26611634; PMCID: PMC4670996.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    63. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev. 2015 Nov 15; 29(22):2362-76. Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL. PMID: 26588989; PMCID: PMC4691891.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    64. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 2015 Nov 05; 163(4):811-28. Yu FX, Zhao B, Guan KL. PMID: 26544935; PMCID: PMC4638384.
      View in: PubMed   Mentions: 968     Fields:    Translation:HumansAnimalsCells
    65. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015 Nov; 5(11):1127-9. Yuan HX, Guan KL. PMID: 26526694; PMCID: PMC4638136.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    66. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nat Cell Biol. 2015 Nov; 17(11):1379-87. Ma T, Li J, Xu Y, Yu C, Xu T, Wang H, Liu K, Cao N, Nie BM, Zhu SY, Xu S, Li K, Wei WG, Wu Y, Guan KL, Ding S. PMID: 26502054.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    67. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015 Oct 05; 6:8357. Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HW, Mo JS, Lu W, Lu S, Flores F, Yu FX, Halder G, Guan KL. PMID: 26437443; PMCID: PMC4600732.
      View in: PubMed   Mentions: 241     Fields:    Translation:HumansAnimalsCells
    68. Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015; 13(9):e1002243. Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan KL. PMID: 26356530; PMCID: PMC4565669.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    69. Alternative Wnt Signaling Activates YAP/TAZ. Cell. 2015 Aug 13; 162(4):780-94. Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan KL. PMID: 26276632; PMCID: PMC4538707.
      View in: PubMed   Mentions: 328     Fields:    Translation:HumansAnimalsCells
    70. Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Cell Res. 2015 Aug; 25(8):985-8. Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX, Xu Y, Guan KL. PMID: 26206313; PMCID: PMC4528059.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    71. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015 Aug; 16(8):975-85. Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan KL. PMID: 26116754; PMCID: PMC4552490.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    72. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84. Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. PMID: 26109050; PMCID: PMC4495398.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    73. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol. 2015 Sep; 25(9):499-513. Hansen CG, Moroishi T, Guan KL. PMID: 26045258; PMCID: PMC4554827.
      View in: PubMed   Mentions: 269     Fields:    Translation:HumansAnimalsCells
    74. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7255-60. Qi Q, Li DY, Luo HR, Guan KL, Ye K. PMID: 26039999; PMCID: PMC4466726.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    75. A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Mol Cell. 2015 Jun 04; 58(5):794-803. Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y. PMID: 25982117; PMCID: PMC4458238.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    76. D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarget. 2015 Apr 20; 6(11):8606-20. Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan KL. PMID: 25825982; PMCID: PMC4496170.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    77. Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest. 2015 May; 125(5):2123-35. Zhou X, Wang S, Wang Z, Feng X, Liu P, Lv XB, Li F, Yu FX, Sun Y, Yuan H, Zhu H, Xiong Y, Lei QY, Guan KL. PMID: 25893606; PMCID: PMC4463207.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    78. The hippo pathway in heart development, regeneration, and diseases. Circ Res. 2015 Apr 10; 116(8):1431-47. Zhou Q, Li L, Zhao B, Guan KL. PMID: 25858067; PMCID: PMC4394208.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    79. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015 Apr; 17(4):500-10. Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan KL. PMID: 25751140; PMCID: PMC4380774.
      View in: PubMed   Mentions: 261     Fields:    Translation:HumansAnimalsCells
    80. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO J. 2015 Apr 15; 34(8):1110-25. Yang H, Zhou L, Shi Q, Zhao Y, Lin H, Zhang M, Zhao S, Yang Y, Ling ZQ, Guan KL, Xiong Y, Ye D. PMID: 25755250; PMCID: PMC4406655.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    81. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. PMID: 25731159; PMCID: PMC4447318.
      View in: PubMed   Mentions: 308     Fields:    Translation:HumansAnimalsCells
    82. Micro(RNA) managing by mTORC1. Mol Cell. 2015 Feb 19; 57(4):575-576. Jewell JL, Flores F, Guan KL. PMID: 25699705; PMCID: PMC4378617.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    83. Disease implications of the Hippo/YAP pathway. Trends Mol Med. 2015 Apr; 21(4):212-22. Plouffe SW, Hong AW, Guan KL. PMID: 25702974; PMCID: PMC4385444.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    84. The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer. 2015 Feb; 15(2):73-79. Moroishi T, Hansen CG, Guan KL. PMID: 25592648; PMCID: PMC4562315.
      View in: PubMed   Mentions: 591     Fields:    Translation:HumansCells
    85. WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell. 2015 Feb 19; 57(4):662-673. Wang Y, Xiao M, Chen X, Chen L, Xu Y, Lv L, Wang P, Yang H, Ma S, Lin H, Jiao B, Ren R, Ye D, Guan KL, Xiong Y. PMID: 25601757; PMCID: PMC4336627.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansCells
    86. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015 Jan 09; 347(6218):194-8. Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL. PMID: 25567907; PMCID: PMC4384888.
      View in: PubMed   Mentions: 357     Fields:    Translation:HumansAnimalsCells
    87. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015 Jan; 125(1):25-32. Kim YC, Guan KL. PMID: 25654547; PMCID: PMC4382265.
      View in: PubMed   Mentions: 721     Fields:    Translation:HumansAnimals
    88. Glutathione-S-transferase (GST)-fusion based assays for studying protein-protein interactions. Methods Mol Biol. 2015; 1278:353-64. Vikis HG, Guan KL. PMID: 25859961.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    89. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014 Dec; 124(12):5453-65. Zhao D, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y, Guan KL, Lei QY. PMID: 25384215; PMCID: PMC4348941.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    90. Hippo pathway regulation of gastrointestinal tissues. Annu Rev Physiol. 2015; 77:201-27. Yu FX, Meng Z, Plouffe SW, Guan KL. PMID: 25293527.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    91. Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene. 2015 Jul; 34(27):3536-46. Liu G, Yu FX, Kim YC, Meng Z, Naipauer J, Looney DJ, Liu X, Gutkind JS, Mesri EA, Guan KL. PMID: 25195862; PMCID: PMC4721508.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    92. Hippo pathway key to ploidy checkpoint. Cell. 2014 Aug 14; 158(4):695-696. Zhao B, Guan KL. PMID: 25126776.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    93. Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun. 2014 Jul 01; 5:4241. Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL. PMID: 24980141; PMCID: PMC4100214.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    94. An alternative DNA damage pathway to apoptosis in hematological cancers. Nat Med. 2014 Jun; 20(6):587-8. Luk JM, Guan KL. PMID: 24901566.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    95. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. PMID: 24882516; PMCID: PMC4075337.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    96. The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep. 2014 Jun; 15(6):642-56. Mo JS, Park HW, Guan KL. PMID: 24825474; PMCID: PMC4197875.
      View in: PubMed   Mentions: 319     Fields:    Translation:HumansCells
    97. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 2014 Jun 17; 33(12):1304-20. Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D. PMID: 24769394; PMCID: PMC4194121.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    98. Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway. EMBO J. 2014 May 02; 33(9):942-4. Yu FX, Guan KL. PMID: 24639555; PMCID: PMC4193929.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    99. mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases. Sci Signal. 2014 Feb 25; 7(314):ra18. Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A, Sugiarto S, Garner M, Paik J, DePinho RA, Goldman D, Guan KL, Shrager JB. PMID: 24570486.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    100. LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction. Cell Rep. 2013 Dec 26; 5(6):1650-63. Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY. PMID: 24360964; PMCID: PMC3897473.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    101. Autophagy regulation by nutrient signaling. Cell Res. 2014 Jan; 24(1):42-57. Russell RC, Yuan HX, Guan KL. PMID: 24343578; PMCID: PMC3879708.
      View in: PubMed   Mentions: 319     Fields:    Translation:AnimalsCells
    102. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy. 2013 Dec; 9(12):1983-95. Yuan HX, Russell RC, Guan KL. PMID: 24013218; PMCID: PMC4028342.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    103. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell. 2013 Nov 07; 52(3):340-52. Lv L, Xu YP, Zhao D, Li FL, Wang W, Sasaki N, Jiang Y, Zhou X, Li TT, Guan KL, Lei QY, Xiong Y. PMID: 24120661; PMCID: PMC4183148.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    104. Regulation of the Hippo pathway and implications for anticancer drug development. Trends Pharmacol Sci. 2013 Oct; 34(10):581-9. Park HW, Guan KL. PMID: 24051213; PMCID: PMC3929107.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    105. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22; 51(4):506-518. Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY. PMID: 23932781; PMCID: PMC4180208.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    106. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013 Jun 01; 27(11):1223-32. Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL. PMID: 23752589; PMCID: PMC3690396.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    107. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol. 2013 Jul; 15(7):741-50. Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. PMID: 23685627; PMCID: PMC3885611.
      View in: PubMed   Mentions: 738     Fields:    Translation:HumansAnimalsCells
    108. AMPK connects energy stress to PIK3C3/VPS34 regulation. Autophagy. 2013 Jul; 9(7):1110-1. Kim J, Guan KL. PMID: 23669030; PMCID: PMC3722323.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    109. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell. 2013 Apr 15; 23(4):464-76. Zhao D, Zou SW, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y, Lei QY, Guan KL. PMID: 23523103; PMCID: PMC3885615.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    110. R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis. Cancer Cell. 2013 Mar 18; 23(3):274-6. Ye D, Ma S, Xiong Y, Guan KL. PMID: 23518346; PMCID: PMC3652525.
      View in: PubMed   Mentions: 45     Fields:    
    111. Nutrient signaling to mTOR and cell growth. Trends Biochem Sci. 2013 May; 38(5):233-42. Jewell JL, Guan KL. PMID: 23465396; PMCID: PMC3634910.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    112. The Hippo pathway: regulators and regulations. Genes Dev. 2013 Feb 15; 27(4):355-71. Yu FX, Guan KL. PMID: 23431053; PMCID: PMC3589553.
      View in: PubMed   Mentions: 629     Fields:    Translation:AnimalsCells
    113. Nutrient sensing, metabolism, and cell growth control. Mol Cell. 2013 Feb 07; 49(3):379-87. Yuan HX, Xiong Y, Guan KL. PMID: 23395268; PMCID: PMC3587157.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    114. Amino acid signalling upstream of mTOR. Nat Rev Mol Cell Biol. 2013 Mar; 14(3):133-9. Jewell JL, Russell RC, Guan KL. PMID: 23361334; PMCID: PMC3988467.
      View in: PubMed   Mentions: 411     Fields:    Translation:HumansAnimalsCells
    115. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 2013 Jan 17; 152(1-2):290-303. Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q, Guan KL. PMID: 23332761; PMCID: PMC3587159.
      View in: PubMed   Mentions: 389     Fields:    Translation:AnimalsCells
    116. YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol. 2012 Dec; 14(12):1322-9. Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan KL. PMID: 23143395; PMCID: PMC4019071.
      View in: PubMed   Mentions: 261     Fields:    Translation:HumansAnimalsCells
    117. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem. 2013 Jan 04; 288(1):703-8. Li L, Guan KL. PMID: 23184942; PMCID: PMC3537069.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    118. Upstream regulators of the Hippo pathway. Cell Cycle. 2012 Nov 15; 11(22):4097-8. Yu FX, Mo JS, Guan KL. PMID: 23075495; PMCID: PMC3524194.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    119. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev. 2012 Oct 01; 26(19):2138-43. Mo JS, Yu FX, Gong R, Brown JH, Guan KL. PMID: 22972936; PMCID: PMC3465735.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    120. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012 Sep 07; 11(3):415-28. Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ. PMID: 22958933; PMCID: PMC3447536.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    121. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17; 150(4):780-91. Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. PMID: 22863277; PMCID: PMC3433174.
      View in: PubMed   Mentions: 805     Fields:    Translation:HumansAnimalsCells
    122. Mechanistic insights into the regulation of metabolic enzymes by acetylation. J Cell Biol. 2012 Jul 23; 198(2):155-64. Xiong Y, Guan KL. PMID: 22826120; PMCID: PMC3410420.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    123. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2012 Jul 27; 287(31):26245-53. Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL. PMID: 22692215; PMCID: PMC3406709.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    124. Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. J Biol Chem. 2012 Aug 03; 287(32):27126-38. Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G. PMID: 22685302; PMCID: PMC3411055.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    125. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2012 Jun 15; 26(12):1326-38. Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL. PMID: 22677546; PMCID: PMC3387660.
      View in: PubMed   Mentions: 491     Fields:    Translation:HumansAnimalsCells
    126. The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. Semin Cell Dev Biol. 2012 Sep; 23(7):785-93. Hong W, Guan KL. PMID: 22659496; PMCID: PMC3459069.
      View in: PubMed   Mentions: 232     Fields:    Translation:HumansAnimalsCells
    127. Organ size control by Hippo and TOR pathways. Curr Biol. 2012 May 08; 22(9):R368-79. Tumaneng K, Russell RC, Guan KL. PMID: 22575479; PMCID: PMC3601681.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimals
    128. The mechanisms of IDH mutations in tumorigenesis. Cell Res. 2012 Jul; 22(7):1102-4. Ye D, Xiong Y, Guan KL. PMID: 22453240; PMCID: PMC3391014.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    129. Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene. 2013 Jan 31; 32(5):663-9. Yang H, Liu Y, Bai F, Zhang JY, Ma SH, Liu J, Xu ZD, Zhu HG, Ling ZQ, Ye D, Guan KL, Xiong Y. PMID: 22391558; PMCID: PMC3897214.
      View in: PubMed   Mentions: 278     Fields:    Translation:HumansAnimalsCells
    130. Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol. 2012 Jun; 23(4):370-80. Oermann EK, Wu J, Guan KL, Xiong Y. PMID: 22306135; PMCID: PMC3351496.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    131. Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab. 2012 Jan 04; 15(1):75-87. Zhang T, Wang S, Lin Y, Xu W, Ye D, Xiong Y, Zhao S, Guan KL. PMID: 22225877; PMCID: PMC3285296.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    132. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev. 2012 Jan 01; 26(1):54-68. Zhao B, Li L, Wang L, Wang CY, Yu J, Guan KL. PMID: 22215811; PMCID: PMC3258966.
      View in: PubMed   Mentions: 414     Fields:    Translation:HumansAnimalsCells
    133. AMPK and mTOR in cellular energy homeostasis and drug targets. Annu Rev Pharmacol Toxicol. 2012; 52:381-400. Inoki K, Kim J, Guan KL. PMID: 22017684.
      View in: PubMed   Mentions: 335     Fields:    Translation:HumansCells
    134. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes Dev. 2011 Aug 15; 25(16):1668-73. Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan KL, Xu Y. PMID: 21816923; PMCID: PMC3165931.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    135. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol. 2011 Aug 01; 13(8):877-83. Zhao B, Tumaneng K, Guan KL. PMID: 21808241; PMCID: PMC3987945.
      View in: PubMed   Mentions: 581     Fields:    Translation:HumansAnimalsCells
    136. An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development. 2011 Aug; 138(16):3343-56. Russell RC, Fang C, Guan KL. PMID: 21791526; PMCID: PMC3143559.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    137. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell. 2011 Jul 08; 43(1):33-44. Jiang W, Wang S, Xiao M, Lin Y, Zhou L, Lei Q, Xiong Y, Guan KL, Zhao S. PMID: 21726808; PMCID: PMC3962309.
      View in: PubMed   Mentions: 199     Fields:    Translation:HumansCells
    138. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell. 2011 Jun 24; 42(6):719-30. Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan KL, Lei QY. PMID: 21700219; PMCID: PMC4879880.
      View in: PubMed   Mentions: 287     Fields:    Translation:HumansAnimalsCells
    139. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest. 2011 Jun; 121(6):2181-96. Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL. PMID: 21606597; PMCID: PMC3104745.
      View in: PubMed   Mentions: 270     Fields:    Translation:AnimalsCells
    140. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6474-9. Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL. PMID: 21464307; PMCID: PMC3081021.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    141. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol. 2011 Mar; 13(3):263-72. Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J. PMID: 21336308; PMCID: PMC3070924.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    142. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011 Feb; 13(2):132-41. Kim J, Kundu M, Viollet B, Guan KL. PMID: 21258367; PMCID: PMC3987946.
      View in: PubMed   Mentions: 3070     Fields:    Translation:HumansAnimalsCells
    143. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell. 2011 Jan 21; 41(2):139-49. Hallows WC, Yu W, Smith BC, Devries MK, Devires MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. PMID: 21255725; PMCID: PMC3101115.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansAnimalsCells
    144. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18; 19(1):17-30. Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y. PMID: 21251613; PMCID: PMC3229304.
      View in: PubMed   Mentions: 1356     Fields:    Translation:HumansAnimalsCells
    145. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 2011 Jan 01; 25(1):51-63. Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL. PMID: 21205866; PMCID: PMC3012936.
      View in: PubMed   Mentions: 350     Fields:    Translation:HumansAnimalsCells
    146. Amino acid signaling in TOR activation. Annu Rev Biochem. 2011; 80:1001-32. Kim J, Guan KL. PMID: 21548787.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    147. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem. 2011 Feb 18; 286(7):5558-66. Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 21189257; PMCID: PMC3037669.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    148. Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci. 2011 Feb; 36(2):108-16. Guan KL, Xiong Y. PMID: 20934340; PMCID: PMC3038179.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    149. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem. 2010 Nov 26; 285(48):37159-69. Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 20858893; PMCID: PMC2988322.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansAnimalsCells
    150. Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc. 2010 Sep; 5(9):1583-95. Guan KL, Yu W, Lin Y, Xiong Y, Zhao S. PMID: 21085124; PMCID: PMC4889332.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    151. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death Differ. 2011 Jan; 18(1):133-44. Kang YJ, Lu MK, Guan KL. PMID: 20616807; PMCID: PMC3131877.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    152. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010 Jun 01; 24(11):1106-18. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL. PMID: 20516196; PMCID: PMC2878649.
      View in: PubMed   Mentions: 385     Fields:    Translation:HumansAnimalsCells
    153. Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem. 2010 Jun 25; 285(26):19705-9. Li L, Kim E, Yuan H, Inoki K, Goraksha-Hicks P, Schiesher RL, Neufeld TP, Guan KL. PMID: 20457610; PMCID: PMC2888380.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    154. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev. 2010 May; 24(9):862-74. Zhao B, Li L, Lei Q, Guan KL. PMID: 20439427; PMCID: PMC2861185.
      View in: PubMed   Mentions: 570     Fields:    Translation:HumansAnimalsCells
    155. Regulation of cellular metabolism by protein lysine acetylation. Science. 2010 Feb 19; 327(5968):1000-4. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. PMID: 20167786; PMCID: PMC3232675.
      View in: PubMed   Mentions: 891     Fields:    Translation:HumansCells
    156. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science. 2010 Feb 19; 327(5968):1004-7. Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao S, Zhao GP. PMID: 20167787; PMCID: PMC4183141.
      View in: PubMed   Mentions: 460     Fields:    Translation:Cells
    157. Structural insights into the YAP and TEAD complex. Genes Dev. 2010 Feb 01; 24(3):235-40. Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan KL, Xu Y. PMID: 20123905; PMCID: PMC2811825.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    158. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev. 2010 Jan 01; 24(1):72-85. Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. PMID: 20048001; PMCID: PMC2802193.
      View in: PubMed   Mentions: 687     Fields:    Translation:HumansCells
    159. Critical roles for the TSC-mTOR pathway in β-cell function. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1013-22. Mori H, Inoki K, Opland D, Münzberg H, Villanueva EC, Faouzi M, Ikenoue T, Kwiatkowski DJ, Macdougald OA, Myers MG, Guan KL. PMID: 19690069; PMCID: PMC2781354.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    160. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med. 2009 Jun; 15(6):682-9. Chang J, Wang Z, Tang E, Fan Z, McCauley L, Franceschi R, Guan K, Krebsbach PH, Wang CY. PMID: 19448637; PMCID: PMC2768554.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimalsCells
    161. Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8923-8. Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL. PMID: 19458266; PMCID: PMC2690031.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    162. Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet. 2009 Apr 15; 18(R1):R94-100. Inoki K, Guan KL. PMID: 19297407; PMCID: PMC2657945.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    163. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009 Apr 10; 324(5924):261-5. Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y. PMID: 19359588; PMCID: PMC3251015.
      View in: PubMed   Mentions: 559     Fields:    Translation:HumansCells
    164. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab. 2009 Apr; 9(4):362-74. Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG, Guan KL. PMID: 19356717; PMCID: PMC2790375.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    165. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009 May 15; 284(20):13355-13362. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 19324877; PMCID: PMC2679435.
      View in: PubMed   Mentions: 298     Fields:    Translation:HumansCells
    166. Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem. 2009 May 15; 284(20):13669-13675. Yu W, Lin Y, Yao J, Huang W, Lei Q, Xiong Y, Zhao S, Guan KL. PMID: 19318352; PMCID: PMC2679468.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    167. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res. 2009 Feb 01; 69(3):1089-98. Zhao B, Kim J, Ye X, Lai ZC, Guan KL. PMID: 19141641.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    168. PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 2008 Sep 01; 68(17):6908-12. Ikenoue T, Inoki K, Zhao B, Guan KL. PMID: 18757404.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    169. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol. 2008 Aug; 10(8):935-45. Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL. PMID: 18604198; PMCID: PMC2711503.
      View in: PubMed   Mentions: 694     Fields:    Translation:HumansAnimalsCells
    170. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008 Jul 15; 22(14):1962-71. Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang CY, Chinnaiyan AM, Lai ZC, Guan KL. PMID: 18579750; PMCID: PMC2492741.
      View in: PubMed   Mentions: 1190     Fields:    Translation:HumansAnimalsCells
    171. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23; 27(14):1919-31. Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. PMID: 18566587; PMCID: PMC2486275.
      View in: PubMed   Mentions: 346     Fields:    Translation:AnimalsCells
    172. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol. 2008 Apr; 28(7):2426-36. Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL. PMID: 18227151; PMCID: PMC2268418.
      View in: PubMed   Mentions: 497     Fields:    Translation:HumansCells
    173. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007 Nov 01; 21(21):2747-61. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL. PMID: 17974916; PMCID: PMC2045129.
      View in: PubMed   Mentions: 1481     Fields:    Translation:HumansAnimalsCells
    174. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 2007 Nov 28; 26(23):4812-23. Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan KL. PMID: 17962806; PMCID: PMC2099465.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    175. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem. 2007 Dec 07; 282(49):35803-13. Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, Guan KL. PMID: 17928295.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    176. Expanding mTOR signaling. Cell Res. 2007 Aug; 17(8):666-81. Yang Q, Guan KL. PMID: 17680028.
      View in: PubMed   Mentions: 247     Fields:    Translation:HumansAnimalsCells
    177. p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci. 2007 Jan 24; 27(4):957-68. Liu G, Li W, Gao X, Li X, Jürgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan KL, Rao Y. PMID: 17251438; PMCID: PMC2014516.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    178. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol. 2007; 47:443-67. Lee CH, Inoki K, Guan KL. PMID: 16968213.
      View in: PubMed   Mentions: 97     Fields:    Translation:Humans
    179. Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene. 2006 Oct 16; 25(48):6347-60. Corradetti MN, Guan KL. PMID: 17041621.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    180. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15; 20(20):2820-32. Yang Q, Inoki K, Ikenoue T, Guan KL. PMID: 17043309; PMCID: PMC1619946.
      View in: PubMed   Mentions: 264     Fields:    Translation:HumansAnimalsCells
    181. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006 Sep 08; 126(5):955-68. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL. PMID: 16959574.
      View in: PubMed   Mentions: 644     Fields:    Translation:HumansAnimalsCells
    182. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6811-6. Yang Q, Inoki K, Kim E, Guan KL. PMID: 16627617; PMCID: PMC1458976.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    183. Complexity of the TOR signaling network. Trends Cell Biol. 2006 Apr; 16(4):206-12. Inoki K, Guan KL. PMID: 16516475.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    184. Semaphorin 4D activates the MAPK pathway downstream of plexin-B1. Biochem J. 2006 Mar 01; 394(Pt 2):459-64. Aurandt J, Li W, Guan KL. PMID: 16187944; PMCID: PMC1408676.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    185. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem. 2006 Mar 31; 281(13):8313-6. Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan KL. PMID: 16464865.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    186. Measurements of TSC2 GAP activity toward Rheb. Methods Enzymol. 2006; 407:46-54. Li Y, Inoki K, Vikis H, Guan KL. PMID: 16757313.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    187. Semaphorins command cells to move. Nat Rev Mol Cell Biol. 2005 Oct; 6(10):789-800. Kruger RP, Aurandt J, Guan KL. PMID: 16314868.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansAnimalsCells
    188. SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans. Mol Cell Biol. 2005 Aug; 25(15):6485-95. Lee J, Li W, Guan KL. PMID: 16024786; PMCID: PMC1190325.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    189. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev. 2005 Mar; 69(1):79-100. Inoki K, Ouyang H, Li Y, Guan KL. PMID: 15755954; PMCID: PMC1082789.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    190. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18; 280(11):9769-72. Corradetti MN, Inoki K, Guan KL. PMID: 15632201.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    191. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005 Jan; 37(1):19-24. Inoki K, Corradetti MN, Guan KL. PMID: 15624019.
      View in: PubMed   Mentions: 405     Fields:    Translation:Humans
    192. Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. J Neurosci. 2004 Dec 01; 24(48):10826-34. Kruger RP, Lee J, Li W, Guan KL. PMID: 15574733; PMCID: PMC6730211.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    193. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci. 2004 Nov; 7(11):1213-21. Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL. PMID: 15494734; PMCID: PMC2373267.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    194. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol. 2004 Sep; 24(18):7965-75. Li Y, Inoki K, Guan KL. PMID: 15340059; PMCID: PMC515062.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    195. Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res. 2004 Aug 01; 64(15):5212-24. Basile JR, Barac A, Zhu T, Guan KL, Gutkind JS. PMID: 15289326.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    196. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2004 Jul 01; 18(13):1533-8. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. PMID: 15231735; PMCID: PMC443516.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimalsCells
    197. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Res. 2004 Mar 15; 64(6):1924-31. Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M. PMID: 15026325.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    198. Glutathione-S-transferase-fusion based assays for studying protein-protein interactions. Methods Mol Biol. 2004; 261:175-86. Vikis HG, Guan KL. PMID: 15064458.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    199. TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem Sci. 2004 Jan; 29(1):32-8. Li Y, Corradetti MN, Inoki K, Guan KL. PMID: 14729330.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    200. Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J. 2004 Jan 14; 23(1):111-9. Yoder JH, Chong H, Guan KL, Han M. PMID: 14685271; PMCID: PMC1271663.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    201. Signalling mechanisms mediating neuronal responses to guidance cues. Nat Rev Neurosci. 2003 Dec; 4(12):941-56. Guan KL, Rao Y. PMID: 14682358.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    202. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003 Nov 26; 115(5):577-90. Inoki K, Zhu T, Guan KL. PMID: 14651849.
      View in: PubMed   Mentions: 1731     Fields:    Translation:HumansAnimalsCells
    203. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. FASEB J. 2003 Nov; 17(14):2048-60. Lanigan TM, Liu A, Huang YZ, Mei L, Margolis B, Guan KL. PMID: 14597674.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    204. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12642-7. Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL, You M. PMID: 14583591; PMCID: PMC240671.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    205. Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. J Biol Chem. 2003 Oct 03; 278(40):38566-70. Tang ED, Inohara N, Wang CY, Nuñez G, Guan KL. PMID: 12890679.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    206. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003 Aug 01; 17(15):1829-34. Inoki K, Li Y, Xu T, Guan KL. PMID: 12869586; PMCID: PMC196227.
      View in: PubMed   Mentions: 846     Fields:    Translation:HumansCells
    207. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem. 2003 Sep 26; 278(39):37297-305. Tang ED, Wang CY, Xiong Y, Guan KL. PMID: 12867425.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    208. Regulation of Raf through phosphorylation and N terminus-C terminus interaction. J Biol Chem. 2003 Sep 19; 278(38):36269-76. Chong H, Guan KL. PMID: 12865432.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    209. Mechanisms of regulating the Raf kinase family. Cell Signal. 2003 May; 15(5):463-9. Chong H, Vikis HG, Guan KL. PMID: 12639709.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    210. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2003 Apr 18; 278(16):13663-71. Li Y, Inoki K, Vacratsis P, Guan KL. PMID: 12582162.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    211. Regulation of TSC2 by 14-3-3 binding. J Biol Chem. 2002 Nov 22; 277(47):44593-6. Li Y, Inoki K, Yeung R, Guan KL. PMID: 12364343.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    212. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002 Sep; 4(9):648-57. Inoki K, Li Y, Zhu T, Wu J, Guan KL. PMID: 12172553.
      View in: PubMed   Mentions: 1318     Fields:    Translation:HumansCells
    213. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12085-90. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. PMID: 12196628; PMCID: PMC129402.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    214. SmgGDS displays differential binding and exchange activity towards different Ras isoforms. Oncogene. 2002 Apr 04; 21(15):2425-32. Vikis HG, Stewart S, Guan KL. PMID: 11948427.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    215. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes Dev. 2002 Apr 01; 16(7):836-45. Vikis HG, Li W, Guan KL. PMID: 11937491; PMCID: PMC186329.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    216. Nonreceptor tyrosine phosphatases in cellular signaling: regulation of mitogen-activated protein kinases. Chem Rev. 2001 Aug; 101(8):2477-96. Zhan XL, Wishart MJ, Guan KL. PMID: 11749384.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    217. Function of the Rho family GTPases in Ras-stimulated Raf activation. J Biol Chem. 2001 Sep 14; 276(37):34728-37. Li W, Chong H, Guan KL. PMID: 11457831.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    218. Positive and negative regulation of Raf kinase activity and function by phosphorylation. EMBO J. 2001 Jul 16; 20(14):3716-27. Chong H, Lee J, Guan KL. PMID: 11447113; PMCID: PMC125532.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    219. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. J Biol Chem. 2001 Aug 24; 276(34):31620-6. Zhang BH, Tang ED, Zhu T, Greenberg ME, Vojtek AB, Guan KL. PMID: 11410590.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    220. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proc Natl Acad Sci U S A. 2000 Nov 07; 97(23):12457-62. Vikis HG, Li W, He Z, Guan KL. PMID: 11035813; PMCID: PMC18785.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    221. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J. 2000 Oct 16; 19(20):5429-39. Zhang BH, Guan KL. PMID: 11032810; PMCID: PMC314015.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    222. Regulation of STAT3 by direct binding to the Rac1 GTPase. Science. 2000 Oct 06; 290(5489):144-7. Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL. PMID: 11021801.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    223. Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem. 2000 Sep 01; 275(35):27354-9. Guan KL, Figueroa C, Brtva TR, Zhu T, Taylor J, Barber TD, Vojtek AB. PMID: 10869359.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    224. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev. 2000 Apr 15; 14(8):895-900. Li W, Han M, Guan KL. PMID: 10783161; PMCID: PMC316541.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    225. The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation. J Biol Chem. 2000 Mar 24; 275(12):8854-62. Stewart S, Guan KL. PMID: 10722731.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    226. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem. 2000 Feb 11; 275(6):4453-9. Xiao G, Jiang D, Thomas P, Benson MD, Guan K, Karsenty G, Franceschi RT. PMID: 10660618.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    227. Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Mol Biol Cell. 2000 Feb; 11(2):663-76. Zhan XL, Hong Y, Zhu T, Mitchell AP, Deschenes RJ, Guan KL. PMID: 10679022; PMCID: PMC14801.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    228. PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Natl Acad Sci U S A. 2000 Jan 04; 97(1):109-14. Tan M, Wang Y, Guan K, Sun Y. PMID: 10618379; PMCID: PMC26624.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    229. A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase. Genes Dev. 1999 Nov 01; 13(21):2811-27. Zhan XL, Guan KL. PMID: 10557209; PMCID: PMC317133.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    230. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol. 1999 Aug; 19(8):5523-34. Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan KL. PMID: 10409742; PMCID: PMC84397.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    231. A G-protein signaling network mediated by an RGS protein. Genes Dev. 1999 Jul 15; 13(14):1763-7. Guan KL, Han M. PMID: 10421628.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    232. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem. 1999 Jun 11; 274(24):16741-6. Tang ED, Nuñez G, Barr FG, Guan KL. PMID: 10358014.
      View in: PubMed   Mentions: 267     Fields:    Translation:Cells
    233. Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6. Cancer Res. 1999 Feb 01; 59(3):558-64. Noh SJ, Li Y, Xiong Y, Guan KL. PMID: 9973200.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    234. Cloning and characterization of GETS-1, a goldfish Ets family member that functions as a transcriptional repressor in muscle. Biochem J. 1998 Oct 15; 335 ( Pt 2):267-75. Goldman D, Sapru MK, Stewart S, Plotkin J, Libermann TA, Wasylyk B, Guan K. PMID: 9761723; PMCID: PMC1219778.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    235. The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation. EMBO J. 1998 Mar 16; 17(6):1717-27. Sugimoto T, Stewart S, Han M, Guan KL. PMID: 9501093; PMCID: PMC1170519.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    236. The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase. J Biol Chem. 1997 Nov 21; 272(47):29415-8. Sugimoto T, Stewart S, Guan KL. PMID: 9367995.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    237. Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Genes Dev. 1997 Jul 01; 11(13):1690-702. Zhan XL, Deschenes RJ, Guan KL. PMID: 9224718.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    238. Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2. J Biol Chem. 1996 Feb 23; 271(8):4230-5. Butch ER, Guan KL. PMID: 8626767.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    239. Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. J Biol Chem. 1996 Feb 09; 271(6):3265-71. Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL. PMID: 8621729.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    240. Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. Mol Biol Cell. 1996 Jan; 7(1):57-70. Guan KL, Jenkins CW, Li Y, O'Keefe CL, Noh S, Wu X, Zariwala M, Matera AG, Xiong Y. PMID: 8741839; PMCID: PMC278612.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    241. Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe. Biochemistry. 1995 Aug 22; 34(33):10560-8. Zhang ZY, Zhou G, Denu JM, Wu L, Tang X, Mondesert O, Russell P, Butch E, Guan KL. PMID: 7654712.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    242. Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans. Development. 1995 Aug; 121(8):2525-35. Church DL, Guan KL, Lambie EJ. PMID: 7671816.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    243. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Am J Physiol. 1995 Jun; 268(6 Pt 1):G1060-5. Duan RD, Zheng CF, Guan KL, Williams JA. PMID: 7611406.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    244. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. J Biol Chem. 1995 Mar 31; 270(13):7197-203. Guan KL, Butch E. PMID: 7535768.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    245. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes Dev. 1995 Mar 15; 9(6):756-68. Kornfeld K, Guan KL, Horvitz HR. PMID: 7729691.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    246. MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes Dev. 1995 Mar 15; 9(6):742-55. Wu Y, Han M, Guan KL. PMID: 7729690.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    247. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 1994 Dec 15; 8(24):2939-52. Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y. PMID: 8001816.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    248. Cytoplasmic localization of the mitogen-activated protein kinase activator MEK. J Biol Chem. 1994 Aug 05; 269(31):19947-52. Zheng CF, Guan KL. PMID: 8051079.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    249. The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. Cell Signal. 1994 Aug; 6(6):581-9. Guan KL. PMID: 7857762.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    250. Growth factor induced MEK activation is primarily mediated by an activator different from c-raf. Biochemistry. 1994 May 10; 33(18):5595-9. Zheng CF, Ohmichi M, Saltiel AR, Guan KL. PMID: 8180183.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    251. Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J. 1994 Mar 01; 13(5):1123-31. Zheng CF, Guan KL. PMID: 8131746; PMCID: PMC394921.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    252. Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. J Biol Chem. 1993 Nov 15; 268(32):23933-9. Zheng CF, Guan KL. PMID: 8226933.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    253. Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase. J Biol Chem. 1993 Aug 05; 268(22):16116-9. Zheng CF, Guan KL. PMID: 8344896.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    254. Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene. Curr Genet. 1993 Jul-Aug; 24(1-2):141-8. Guan K, Farh L, Marshall TK, Deschenes RJ. PMID: 7916673.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    255. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J Biol Chem. 1993 May 25; 268(15):11435-9. Zheng CF, Guan KL. PMID: 8388392.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    256. A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12175-9. Guan K, Hakes DJ, Wang Y, Park HD, Cooper TG, Dixon JE. PMID: 1334559; PMCID: PMC50721.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    257. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. EMBO J. 1992 Dec; 11(13):4943-52. Millar JB, Russell P, Dixon JE, Guan KL. PMID: 1464319; PMCID: PMC556972.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    258. Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae. J Biol Chem. 1992 May 15; 267(14):10024-30. Guan K, Deschenes RJ, Dixon JE. PMID: 1577774.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    259. Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate. J Biol Chem. 1991 Sep 15; 266(26):17026-30. Guan KL, Dixon JE. PMID: 1654322.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    260. Cloning and expression of a yeast protein tyrosine phosphatase. J Biol Chem. 1991 Jul 15; 266(20):12964-70. Guan KL, Deschenes RJ, Qiu H, Dixon JE. PMID: 1649172.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    261. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature. 1991 Mar 28; 350(6316):359-62. Guan KL, Broyles SS, Dixon JE. PMID: 1848923.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    262. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal Biochem. 1991 Feb 01; 192(2):262-7. Guan KL, Dixon JE. PMID: 1852137.
      View in: PubMed   Mentions: 624     Fields:    Translation:AnimalsCells
    263. Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science. 1990 Aug 03; 249(4968):553-6. Guan KL, Dixon JE. PMID: 2166336.
      View in: PubMed   Mentions: 169     Fields:    Translation:Cells
    264. Sequence of the precursor of bovine liver mitochondrial aldehyde dehydrogenase as determined from its cDNA, its gene, and its functionality. Arch Biochem Biophys. 1990 Mar; 277(2):351-60. Guan KL, Weiner H. PMID: 1689984.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    265. Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1501-5. Guan KL, Haun RS, Watson SJ, Geahlen RL, Dixon JE. PMID: 2154749; PMCID: PMC53503.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    266. Influence of the 5'-end region of aldehyde dehydrogenase mRNA on translational efficiency. Potential secondary structure inhibition of translation in vitro. J Biol Chem. 1989 Oct 25; 264(30):17764-9. Guan KL, Weiner H. PMID: 2808349.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    267. Purification and characterization of beef and pig liver aldehyde dehydrogenases. Alcohol Clin Exp Res. 1988 Oct; 12(5):713-9. Guan KL, Pak YK, Tu GC, Cao QN, Weiner H. PMID: 3067621.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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