Kun-liang Guan

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Purdue University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanism and Therapy for Ocular Melanoma
    NIH R01CA217642Mar 14, 2017 - Feb 28, 2023
    Role: Co-Principal Investigator
    The mTOR and Hippo pathway in cell growth and cancer
    NIH R35CA196878Aug 5, 2015 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of the Hippo pathway and its role in uveal melanoma
    NIH R01EY022611Sep 1, 2012 - Aug 31, 2016
    Role: Principal Investigator
    Regulation and function of the YAP transcription co-activator oncoprotein
    NIH R01CA132809Apr 8, 2008 - Feb 28, 2018
    Role: Principal Investigator
    Rag GTPases in mTOR regulation and physiological functions
    NIH R01CA108941Sep 3, 2004 - Jun 30, 2019
    Role: Principal Investigator
    S6K and mTOR as targets for tuberous sclerosis
    NIH R41CA101611Jul 1, 2003 - Jun 30, 2004
    Role: Principal Investigator
    Regulation of Ras and Rheb modification by GCN2
    NIH R01GM062694Jul 1, 2000 - Jun 30, 2012
    Role: Principal Investigator
    REGULATION OF PROTEIN TYROSINE PHOSPHORYLATION IN YEAST
    NIH R01GM055642May 1, 1997 - Apr 30, 2001
    Role: Principal Investigator
    Protein phosphorylation and growth factor function
    NIH R01GM051586Aug 1, 1994 - Jun 30, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rheb regulates nuclear mTORC1 activity independent of farnesylation. Cell Chem Biol. 2022 06 16; 29(6):1037-1045.e4. Zhong Y, Zhou X, Guan KL, Zhang J. PMID: 35294906.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses. Nat Cell Biol. 2022 03; 24(3):353-363. Chen LL, Morcelle C, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M, Zhu Y, Zhou N, Cheng M, He C, Liu KY, Lu G, Zhang L, Zhang C, Zhang J, Sun Y, Qi T, Lyu Y, Ren ZZ, Tan XM, Yin J, Lan F, Liu Y, Yang H, Qian M, Duan C, Chang X, Zhou Y, Shen L, Baldwin AS, Guan KL, Xiong Y, Ye D. PMID: 35256775; PMCID: PMC9305987.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    3. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer. Nat Commun. 2022 02 25; 13(1):1061. Ma S, Tang T, Probst G, Konradi A, Jin C, Li F, Gutkind JS, Fu XD, Guan KL. PMID: 35217640; PMCID: PMC8881512.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Rag GTPases regulate cellular amino acid homeostasis. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). Inoki K, Guan KL. PMID: 35177479; PMCID: PMC8872802.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence. Mol Oncol. 2022 02; 16(3):607-629. Yu L, Zhou D, Zhang G, Ren Z, Luo X, Liu P, Plouffe SW, Meng Z, Moroishi T, Li Y, Zhang Y, Brown JH, Liu S, Guan KL. PMID: 34706158; PMCID: PMC8807356.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. The two sides of Hippo pathway in cancer. Semin Cancer Biol. 2022 10; 85:33-42. Li FL, Guan KL. PMID: 34265423.
      View in: PubMed   Mentions: 4     Fields:    
    7. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 06; 20(6):986-998. Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. PMID: 33850002.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    8. Hippo signalling maintains ER expression and ER+ breast cancer growth. Nature. 2021 03; 591(7848):E1-E10. Ma S, Wu Z, Yang F, Zhang J, Johnson RL, Rosenfeld MG, Guan KL. PMID: 33658690; PMCID: PMC8725601.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells. Sci Adv. 2021 01; 7(5). Wang Y, Wu J, Chen H, Yang Y, Xiao C, Yi X, Shi C, Zhong K, He H, Li Y, Wu Z, Zhou G, Rao Q, Wang X, Zhou X, Lomberk G, Liu B, Zhao J, Ge J, Zhou W, Chu X, Chen C, Zhou X, Wang L, Guan K, Qu L. PMID: 33571129; PMCID: PMC7840125.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Structural insights into TSC complex assembly and GAP activity on Rheb. Nat Commun. 2021 01 12; 12(1):339. Yang H, Yu Z, Chen X, Li J, Li N, Cheng J, Gao N, Yuan HX, Ye D, Guan KL, Xu Y. PMID: 33436626; PMCID: PMC7804450.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. Heat stress activates YAP/TAZ to induce the heat shock transcriptome. Nat Cell Biol. 2020 12; 22(12):1447-1459. Luo M, Meng Z, Moroishi T, Lin KC, Shen G, Mo F, Shao B, Wei X, Zhang P, Wei Y, Guan KL. PMID: 33199845; PMCID: PMC7757600.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    12. Hippo Signaling in Embryogenesis and Development. Trends Biochem Sci. 2021 01; 46(1):51-63. Wu Z, Guan KL. PMID: 32928629; PMCID: PMC7749079.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    13. A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. Cell Rep. 2020 09 08; 32(10):108118. Lin Z, Xie R, Guan K, Zhang M. PMID: 32905778; PMCID: PMC7494017.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. 2020 07; 19(7):480-494. Dey A, Varelas X, Guan KL. PMID: 32555376; PMCID: PMC7880238.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    15. LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction. Cell Rep. 2020 Jun 16; 31(11):107792. Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY. PMID: 32553156; PMCID: PMC7380863.
      View in: PubMed   Mentions: 1     Fields:    
    16. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. 2020 08 06; 27(2):224-237.e6. Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan KL, Malmberg KJ, Kaufman DS. PMID: 32531207; PMCID: PMC7415618.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    17. Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis. Cell Stem Cell. 2020 05 07; 26(5):612-614. Fu V, Guan KL. PMID: 32386550.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. YAP/TAZ phase separation for transcription. Nat Cell Biol. 2020 04; 22(4):357-358. Franklin JM, Guan KL. PMID: 32203419.
      View in: PubMed   Mentions: 7     Fields:    
    19. Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Genes Dev. 2020 04 01; 34(7-8):511-525. Hong AW, Meng Z, Plouffe SW, Lin Z, Zhang M, Guan KL. PMID: 32115406; PMCID: PMC7111263.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes Dev. 2020 01 01; 34(1-2):72-86. Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL. PMID: 31831627; PMCID: PMC6938666.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    21. STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat Cell Biol. 2019 12; 21(12):1565-1577. Chen R, Xie R, Meng Z, Ma S, Guan KL. PMID: 31792377.
      View in: PubMed   Mentions: 28     Fields:    
    22. Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation. Blood. 2019 11 14; 134(20):1730-1744. Stoner SA, Yan M, Liu KTH, Arimoto KI, Shima T, Wang HY, Johnson DT, Bejar R, Jamieson C, Guan KL, Zhang DE. PMID: 31434702; PMCID: PMC6856986.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 12 17; 51(6):1012-1027.e7. Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H. PMID: 31668641; PMCID: PMC6948188.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    24. Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity. Elife. 2019 09 05; 8. Lin Z, Yang Z, Xie R, Ji Z, Guan K, Zhang M. PMID: 31486770; PMCID: PMC6744271.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. YAP and TAZ regulate cell volume. J Cell Biol. 2019 10 07; 218(10):3472-3488. Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S, Wirtz D, Petrie RJ, Guan KL, Sun SX. PMID: 31481532; PMCID: PMC6781432.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. The Hippo Pathway: Biology and Pathophysiology. Annu Rev Biochem. 2019 06 20; 88:577-604. Ma S, Meng Z, Chen R, Guan KL. PMID: 30566373.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansAnimalsCells
    27. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019 05 21; 8. Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. PMID: 31112131; PMCID: PMC6529218.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    28. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell. 2019 06; 18(3):e12943. Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB. PMID: 30924297; PMCID: PMC6516169.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    29. BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7363-7370. Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, Guan KL, Verma IM. PMID: 30918126; PMCID: PMC6462108.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. mTOR as a central hub of nutrient signalling and cell growth. Nat Cell Biol. 2019 01; 21(1):63-71. Kim J, Guan KL. PMID: 30602761.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansAnimalsCells
    31. Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag. Methods Mol Biol. 2019; 1893:281-287. Chen R, Plouffe SW, Guan KL. PMID: 30565141.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    32. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019 04; 38(14):2595-2610. Pan WW, Moroishi T, Koo JH, Guan KL. PMID: 30531839; PMCID: PMC6450751.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    33. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Mol Cell. 2019 01 03; 73(1):7-21.e7. Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. PMID: 30472188.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    34. SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Rep. 2018 11 06; 25(6):1485-1500.e4. Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL. PMID: 30404004; PMCID: PMC6317994.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    35. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. Cell Rep. 2018 Nov 06; 25(6):1680. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30404018; PMCID: PMC7337229.
      View in: PubMed   Mentions: 6     Fields:    
    36. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. PMID: 30135582; PMCID: PMC6128698.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    37. Interplay between YAP/TAZ and Metabolism. Cell Metab. 2018 08 07; 28(2):196-206. Koo JH, Guan KL. PMID: 30089241.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    38. Polycystic kidney disease: a Hippo connection. Genes Dev. 2018 06 01; 32(11-12):737-739. Ma S, Guan KL. PMID: 29921661; PMCID: PMC6049516.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    39. The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell. J Biol Chem. 2018 07 13; 293(28):11230-11240. Plouffe SW, Lin KC, Moore JL, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL. PMID: 29802201; PMCID: PMC6052207.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    40. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep. 2018 05; 19(5). Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D. PMID: 29491006; PMCID: PMC5934778.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    41. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018 02 06; 9(1):508. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX. PMID: 29410405; PMCID: PMC5802808.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    42. The Hippo pathway in organ development, homeostasis, and regeneration. Curr Opin Cell Biol. 2017 12; 49:99-107. Fu V, Plouffe SW, Guan KL. PMID: 29316535; PMCID: PMC6348871.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    43. Colonic epithelium rejuvenation through YAP/TAZ. EMBO J. 2018 01 17; 37(2):164-166. Chen R, Guan KL. PMID: 29282206; PMCID: PMC5770785.
      View in: PubMed   Mentions: 1     Fields:    
    44. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 05; 68(1):198-209.e6. Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL. PMID: 28985504.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    45. Regulation of the Hippo Pathway Transcription Factor TEAD. Trends Biochem Sci. 2017 11; 42(11):862-872. Lin KC, Park HW, Guan KL. PMID: 28964625; PMCID: PMC5735856.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    46. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. PMID: 28752853; PMCID: PMC5541894.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    47. Non-radioactive LATS in vitro Kinase Assay. Bio Protoc. 2017 Jul 20; 7(14). Hong AW, Guan KL. PMID: 29104896; PMCID: PMC5669374.
      View in: PubMed   Mentions: 2  
    48. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. PMID: 28648777; PMCID: PMC5521991.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    49. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B. PMID: 28417999; PMCID: PMC5490986.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    50. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 04 15; 77(8):1997-2007. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL. PMID: 28381547; PMCID: PMC5392372.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    51. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017 04 15; 37(8). Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL. PMID: 28137912; PMCID: PMC5376639.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    52. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 04; 19(4):362-374. Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan KL, Xu P. PMID: 28346439; PMCID: PMC5398908.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    53. Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Res. 2017 05 01; 77(9):2413-2423. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan KL. PMID: 28249901; PMCID: PMC6724531.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    54. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep. 2017 01; 18(1):72-86. Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL. PMID: 27979971; PMCID: PMC5210094.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    55. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL. PMID: 27912060; PMCID: PMC5512418.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    56. Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell. 2016 12 01; 64(5):993-1008. Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV, Guan KL. PMID: 27912098; PMCID: PMC5137798.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    57. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 09 02; 291(36):18947-58. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng Z, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan KL. PMID: 27382053; PMCID: PMC5009267.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    58. The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol. 2016 06; 13(6):324-37. Hong AW, Meng Z, Guan KL. PMID: 27147489; PMCID: PMC5642988.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    59. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 2016 Mar; 26(3):397-405. Diao Y, Li B, Meng Z, Jung I, Lee AY, Dixon J, Maliskova L, Guan KL, Shen Y, Ren B. PMID: 26813977; PMCID: PMC4772021.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    60. Structural insights of mTOR complex 1. Cell Res. 2016 Mar; 26(3):267-8. Yuan HX, Guan KL. PMID: 26794870; PMCID: PMC4783463.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    61. Mechanisms of Hippo pathway regulation. Genes Dev. 2016 Jan 01; 30(1):1-17. Meng Z, Moroishi T, Guan KL. PMID: 26728553; PMCID: PMC4701972.
      View in: PubMed   Mentions: 587     Fields:    Translation:HumansAnimalsCells
    62. The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Res. 2015 Dec; 25(12):1299-313. Hansen CG, Ng YL, Lam WL, Plouffe SW, Guan KL. PMID: 26611634; PMCID: PMC4670996.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    63. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev. 2015 Nov 15; 29(22):2362-76. Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL. PMID: 26588989; PMCID: PMC4691891.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    64. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 2015 Nov 05; 163(4):811-28. Yu FX, Zhao B, Guan KL. PMID: 26544935; PMCID: PMC4638384.
      View in: PubMed   Mentions: 825     Fields:    Translation:HumansAnimalsCells
    65. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015 Nov; 5(11):1127-9. Yuan HX, Guan KL. PMID: 26526694; PMCID: PMC4638136.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
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    216. Nonreceptor tyrosine phosphatases in cellular signaling: regulation of mitogen-activated protein kinases. Chem Rev. 2001 Aug; 101(8):2477-96. Zhan XL, Wishart MJ, Guan KL. PMID: 11749384.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    217. Function of the Rho family GTPases in Ras-stimulated Raf activation. J Biol Chem. 2001 Sep 14; 276(37):34728-37. Li W, Chong H, Guan KL. PMID: 11457831.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    218. Positive and negative regulation of Raf kinase activity and function by phosphorylation. EMBO J. 2001 Jul 16; 20(14):3716-27. Chong H, Lee J, Guan KL. PMID: 11447113; PMCID: PMC125532.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    219. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. J Biol Chem. 2001 Aug 24; 276(34):31620-6. Zhang BH, Tang ED, Zhu T, Greenberg ME, Vojtek AB, Guan KL. PMID: 11410590.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    220. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proc Natl Acad Sci U S A. 2000 Nov 07; 97(23):12457-62. Vikis HG, Li W, He Z, Guan KL. PMID: 11035813; PMCID: PMC18785.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    221. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J. 2000 Oct 16; 19(20):5429-39. Zhang BH, Guan KL. PMID: 11032810; PMCID: PMC314015.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    222. Regulation of STAT3 by direct binding to the Rac1 GTPase. Science. 2000 Oct 06; 290(5489):144-7. Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL. PMID: 11021801.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    223. Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem. 2000 Sep 01; 275(35):27354-9. Guan KL, Figueroa C, Brtva TR, Zhu T, Taylor J, Barber TD, Vojtek AB. PMID: 10869359.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    224. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev. 2000 Apr 15; 14(8):895-900. Li W, Han M, Guan KL. PMID: 10783161; PMCID: PMC316541.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    225. The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation. J Biol Chem. 2000 Mar 24; 275(12):8854-62. Stewart S, Guan KL. PMID: 10722731.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    226. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem. 2000 Feb 11; 275(6):4453-9. Xiao G, Jiang D, Thomas P, Benson MD, Guan K, Karsenty G, Franceschi RT. PMID: 10660618.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    227. Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Mol Biol Cell. 2000 Feb; 11(2):663-76. Zhan XL, Hong Y, Zhu T, Mitchell AP, Deschenes RJ, Guan KL. PMID: 10679022; PMCID: PMC14801.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    228. PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Natl Acad Sci U S A. 2000 Jan 04; 97(1):109-14. Tan M, Wang Y, Guan K, Sun Y. PMID: 10618379; PMCID: PMC26624.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    229. A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase. Genes Dev. 1999 Nov 01; 13(21):2811-27. Zhan XL, Guan KL. PMID: 10557209; PMCID: PMC317133.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    230. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol. 1999 Aug; 19(8):5523-34. Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan KL. PMID: 10409742; PMCID: PMC84397.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    231. A G-protein signaling network mediated by an RGS protein. Genes Dev. 1999 Jul 15; 13(14):1763-7. Guan KL, Han M. PMID: 10421628.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    232. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem. 1999 Jun 11; 274(24):16741-6. Tang ED, Nuñez G, Barr FG, Guan KL. PMID: 10358014.
      View in: PubMed   Mentions: 263     Fields:    Translation:Cells
    233. Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6. Cancer Res. 1999 Feb 01; 59(3):558-64. Noh SJ, Li Y, Xiong Y, Guan KL. PMID: 9973200.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    234. Cloning and characterization of GETS-1, a goldfish Ets family member that functions as a transcriptional repressor in muscle. Biochem J. 1998 Oct 15; 335 ( Pt 2):267-75. Goldman D, Sapru MK, Stewart S, Plotkin J, Libermann TA, Wasylyk B, Guan K. PMID: 9761723; PMCID: PMC1219778.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    235. The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation. EMBO J. 1998 Mar 16; 17(6):1717-27. Sugimoto T, Stewart S, Han M, Guan KL. PMID: 9501093; PMCID: PMC1170519.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    236. The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase. J Biol Chem. 1997 Nov 21; 272(47):29415-8. Sugimoto T, Stewart S, Guan KL. PMID: 9367995.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    237. Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Genes Dev. 1997 Jul 01; 11(13):1690-702. Zhan XL, Deschenes RJ, Guan KL. PMID: 9224718.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    238. Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2. J Biol Chem. 1996 Feb 23; 271(8):4230-5. Butch ER, Guan KL. PMID: 8626767.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    239. Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. J Biol Chem. 1996 Feb 09; 271(6):3265-71. Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL. PMID: 8621729.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    240. Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. Mol Biol Cell. 1996 Jan; 7(1):57-70. Guan KL, Jenkins CW, Li Y, O'Keefe CL, Noh S, Wu X, Zariwala M, Matera AG, Xiong Y. PMID: 8741839; PMCID: PMC278612.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    241. Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe. Biochemistry. 1995 Aug 22; 34(33):10560-8. Zhang ZY, Zhou G, Denu JM, Wu L, Tang X, Mondesert O, Russell P, Butch E, Guan KL. PMID: 7654712.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    242. Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans. Development. 1995 Aug; 121(8):2525-35. Church DL, Guan KL, Lambie EJ. PMID: 7671816.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    243. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Am J Physiol. 1995 Jun; 268(6 Pt 1):G1060-5. Duan RD, Zheng CF, Guan KL, Williams JA. PMID: 7611406.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    244. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. J Biol Chem. 1995 Mar 31; 270(13):7197-203. Guan KL, Butch E. PMID: 7535768.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    245. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes Dev. 1995 Mar 15; 9(6):756-68. Kornfeld K, Guan KL, Horvitz HR. PMID: 7729691.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    246. MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes Dev. 1995 Mar 15; 9(6):742-55. Wu Y, Han M, Guan KL. PMID: 7729690.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    247. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 1994 Dec 15; 8(24):2939-52. Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y. PMID: 8001816.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    248. Cytoplasmic localization of the mitogen-activated protein kinase activator MEK. J Biol Chem. 1994 Aug 05; 269(31):19947-52. Zheng CF, Guan KL. PMID: 8051079.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    249. The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. Cell Signal. 1994 Aug; 6(6):581-9. Guan KL. PMID: 7857762.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    250. Growth factor induced MEK activation is primarily mediated by an activator different from c-raf. Biochemistry. 1994 May 10; 33(18):5595-9. Zheng CF, Ohmichi M, Saltiel AR, Guan KL. PMID: 8180183.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    251. Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J. 1994 Mar 01; 13(5):1123-31. Zheng CF, Guan KL. PMID: 8131746; PMCID: PMC394921.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    252. Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. J Biol Chem. 1993 Nov 15; 268(32):23933-9. Zheng CF, Guan KL. PMID: 8226933.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    253. Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase. J Biol Chem. 1993 Aug 05; 268(22):16116-9. Zheng CF, Guan KL. PMID: 8344896.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    254. Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene. Curr Genet. 1993 Jul-Aug; 24(1-2):141-8. Guan K, Farh L, Marshall TK, Deschenes RJ. PMID: 7916673.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    255. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J Biol Chem. 1993 May 25; 268(15):11435-9. Zheng CF, Guan KL. PMID: 8388392.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    256. A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12175-9. Guan K, Hakes DJ, Wang Y, Park HD, Cooper TG, Dixon JE. PMID: 1334559; PMCID: PMC50721.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    257. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. EMBO J. 1992 Dec; 11(13):4943-52. Millar JB, Russell P, Dixon JE, Guan KL. PMID: 1464319; PMCID: PMC556972.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    258. Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae. J Biol Chem. 1992 May 15; 267(14):10024-30. Guan K, Deschenes RJ, Dixon JE. PMID: 1577774.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    259. Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate. J Biol Chem. 1991 Sep 15; 266(26):17026-30. Guan KL, Dixon JE. PMID: 1654322.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    260. Cloning and expression of a yeast protein tyrosine phosphatase. J Biol Chem. 1991 Jul 15; 266(20):12964-70. Guan KL, Deschenes RJ, Qiu H, Dixon JE. PMID: 1649172.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    261. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature. 1991 Mar 28; 350(6316):359-62. Guan KL, Broyles SS, Dixon JE. PMID: 1848923.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    262. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal Biochem. 1991 Feb 01; 192(2):262-7. Guan KL, Dixon JE. PMID: 1852137.
      View in: PubMed   Mentions: 644     Fields:    Translation:AnimalsCells
    263. Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science. 1990 Aug 03; 249(4968):553-6. Guan KL, Dixon JE. PMID: 2166336.
      View in: PubMed   Mentions: 167     Fields:    Translation:Cells
    264. Sequence of the precursor of bovine liver mitochondrial aldehyde dehydrogenase as determined from its cDNA, its gene, and its functionality. Arch Biochem Biophys. 1990 Mar; 277(2):351-60. Guan KL, Weiner H. PMID: 1689984.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    265. Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1501-5. Guan KL, Haun RS, Watson SJ, Geahlen RL, Dixon JE. PMID: 2154749; PMCID: PMC53503.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    266. Influence of the 5'-end region of aldehyde dehydrogenase mRNA on translational efficiency. Potential secondary structure inhibition of translation in vitro. J Biol Chem. 1989 Oct 25; 264(30):17764-9. Guan KL, Weiner H. PMID: 2808349.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    267. Purification and characterization of beef and pig liver aldehyde dehydrogenases. Alcohol Clin Exp Res. 1988 Oct; 12(5):713-9. Guan KL, Pak YK, Tu GC, Cao QN, Weiner H. PMID: 3067621.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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