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Kun-Liang Guan

Title(s)Professor, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-822-7945
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Purdue University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanism and Therapy for Ocular Melanoma
    NIH/NCI R01CA217642Mar 14, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    The mTOR and Hippo pathway in cell growth and cancer
    NIH/NCI R35CA196878Aug 5, 2015 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of the Hippo pathway and its role in uveal melanoma
    NIH/NEI R01EY022611Sep 1, 2012 - Aug 31, 2016
    Role: Principal Investigator
    Regulation and function of the YAP transcription co-activator oncoprotein
    NIH/NCI R01CA132809Apr 8, 2008 - Feb 28, 2018
    Role: Principal Investigator
    Rag GTPases in mTOR regulation and physiological functions
    NIH/NCI R01CA108941Sep 3, 2004 - Sep 30, 2007
    Role: Principal Investigator
    S6K and mTOR as targets for tuberous sclerosis
    NIH/NCI R41CA101611Jul 1, 2003 - Jun 30, 2004
    Role: Principal Investigator
    Regulation of Ras and Rheb modification by GCN2
    NIH/NIGMS R01GM062694Jul 1, 2000 - Sep 30, 2007
    Role: Principal Investigator
    REGULATION OF PROTEIN TYROSINE PHOSPHORYLATION IN YEAST
    NIH/NIGMS R01GM055642May 1, 1997 - Apr 30, 2001
    Role: Principal Investigator
    Protein phosphorylation and growth factor function
    NIH/NIGMS R01GM051586Aug 1, 1994 - Sep 30, 2007
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. 2020 Jun 10. Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan KL, Malmberg KJ, Kaufman DS. PMID: 32531207.
      View in: PubMed   Mentions: 1     Fields:    
    2. Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis. Cell Stem Cell. 2020 May 07; 26(5):612-614. Fu V, Guan KL. PMID: 32386550.
      View in: PubMed   Mentions:    Fields:    
    3. EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability. Cancer Res. 2020 Jun 15; 80(12):2550-2563. Zhou Z, Zhou H, Ponzoni L, Luo A, Zhu R, He M, Huang Y, Guan KL, Bahar I, Liu Z, Wan Y. PMID: 32269044.
      View in: PubMed   Mentions:    Fields:    
    4. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell Metab. 2020 May 05; 31(5):969-986.e7. Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I. PMID: 32259482.
      View in: PubMed   Mentions:    Fields:    
    5. YAP/TAZ phase separation for transcription. Nat Cell Biol. 2020 04; 22(4):357-358. Franklin JM, Guan KL. PMID: 32203419.
      View in: PubMed   Mentions: 1     Fields:    
    6. Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver Int. 2020 Jun; 40(6):1378-1394. Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, Guan KL, Xiong Y, Liu J, Yuan HX. PMID: 32145145.
      View in: PubMed   Mentions:    Fields:    
    7. Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Genes Dev. 2020 Apr 01; 34(7-8):511-525. Hong AW, Meng Z, Plouffe SW, Lin Z, Zhang M, Guan KL. PMID: 32115406.
      View in: PubMed   Mentions:    Fields:    
    8. Publisher Correction: STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat Cell Biol. 2020 Feb; 22(2):257. Chen R, Xie R, Meng Z, Ma S, Guan KL. PMID: 31896773.
      View in: PubMed   Mentions:    Fields:    
    9. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes Dev. 2020 01 01; 34(1-2):72-86. Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL. PMID: 31831627.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Volume Adaptation Controls Stem Cell Mechanotransduction. ACS Appl Mater Interfaces. 2019 Dec 11; 11(49):45520-45530. Major LG, Holle AW, Young JL, Hepburn MS, Jeong K, Chin IL, Sanderson RW, Jeong JH, Aman ZM, Kennedy BF, Hwang Y, Han DW, Park HW, Guan KL, Spatz JP, Choi YS. PMID: 31714734.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat Cell Biol. 2019 12; 21(12):1565-1577. Chen R, Xie R, Meng Z, Ma S, Guan KL. PMID: 31792377.
      View in: PubMed   Mentions:    Fields:    
    12. Hippo kinase loss contributes to del(20q) hematologic malignancies through chronic innate immune activation. Blood. 2019 11 14; 134(20):1730-1744. Stoner SA, Yan M, Liu KTH, Arimoto KI, Shima T, Wang HY, Johnson DT, Bejar R, Jamieson C, Guan KL, Zhang DE. PMID: 31434702.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019 12 17; 51(6):1012-1027.e7. Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H. PMID: 31668641.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019 10 07; 10(10):755. Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, Yuan HX. PMID: 31591388.
      View in: PubMed   Mentions:    Fields:    
    15. Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity. Elife. 2019 09 05; 8. Lin Z, Yang Z, Xie R, Ji Z, Guan K, Zhang M. PMID: 31486770.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. YAP and TAZ regulate cell volume. J Cell Biol. 2019 10 07; 218(10):3472-3488. Perez-Gonzalez NA, Rochman ND, Yao K, Tao J, Le MT, Flanary S, Sablich L, Toler B, Crentsil E, Takaesu F, Lambrus B, Huang J, Fu V, Chengappa P, Jones TM, Holland AJ, An S, Wirtz D, Petrie RJ, Guan KL, Sun SX. PMID: 31481532.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). Biochem J. 2019 08 15; 476(15):2239-2254. Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, Yuan HX. PMID: 31341009.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. The Hippo Pathway: Biology and Pathophysiology. Annu Rev Biochem. 2019 06 20; 88:577-604. Ma S, Meng Z, Chen R, Guan KL. PMID: 30566373.
      View in: PubMed   Mentions: 5     Fields:    
    19. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019 05 21; 8. Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. PMID: 31112131.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. Withdrawal: Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. J Biol Chem. 2019 May 17; 294(20):8310. Li W, Zhu T, Guan KL. PMID: 31101660.
      View in: PubMed   Mentions:    Fields:    
    21. A special issue to mark the 90th Anniversary of College of Life Sciences, Zhejiang University. J Zhejiang Univ Sci B. 2019 May; 20(5):371-372. Peng JR, Guan KL, Hong DY, Lin XH, Yang HM, Zhu YX. PMID: 31090262.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Correction: The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2019 Apr 12; 294(15):5807. Li Y, Inoki K, Vacratsis P, Guan KL. PMID: 30979849.
      View in: PubMed   Mentions:    Fields:    
    23. Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2019 Apr 12; 294(15):5808. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 30979850.
      View in: PubMed   Mentions:    Fields:    
    24. Correction: The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFß-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2019 Apr 12; 294(15):5809. Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL. PMID: 30979851.
      View in: PubMed   Mentions:    Fields:    
    25. Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2019 04 01; 33(7-8):477. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. PMID: 30936192.
      View in: PubMed   Mentions:    Fields:    
    26. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell. 2019 06; 18(3):e12943. Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB. PMID: 30924297.
      View in: PubMed   Mentions: 4     Fields:    
    27. BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7363-7370. Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, Guan KL, Verma IM. PMID: 30918126.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. Retraction: FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5 (doi: 10.1242/jcs.02697). J Cell Sci. 2019 02 19; 132(5). Li W, Aurandt J, Jürgensen C, Rao Y, Guan KL. PMID: 30782981.
      View in: PubMed   Mentions:    Fields:    
    29. SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress. PLoS One. 2019; 14(2):e0211796. Zhang M, Wu J, Sun R, Tao X, Wang X, Kang Q, Wang H, Zhang L, Liu P, Zhang J, Xia Y, Zhao Y, Yang Y, Xiong Y, Guan KL, Zou Y, Ye D. PMID: 30759120.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    30. mTOR as a central hub of nutrient signalling and cell growth. Nat Cell Biol. 2019 01; 21(1):63-71. Kim J, Guan KL. PMID: 30602761.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    31. Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag. Methods Mol Biol. 2019; 1893:281-287. Chen R, Plouffe SW, Guan KL. PMID: 30565141.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    32. Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry. Lab Invest. 2019 04; 99(4):588-598. Xu H, Xia YK, Li CJ, Zhang JY, Liu Y, Yi W, Qin ZY, Chen L, Shi ZF, Quan K, Yang ZX, Guan KL, Xiong Y, Ng HK, Ye D, Hua W, Mao Y. PMID: 30573870.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019 04; 38(14):2595-2610. Pan WW, Moroishi T, Koo JH, Guan KL. PMID: 30531839.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    34. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Mol Cell. 2019 01 03; 73(1):7-21.e7. Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. PMID: 30472188.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    35. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. Cell Rep. 2018 Nov 06; 25(6):1680. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30404018.
      View in: PubMed   Mentions:    Fields:    
    36. SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Rep. 2018 11 06; 25(6):1485-1500.e4. Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY, Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, Lan F, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL. PMID: 30404004.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    37. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. Cell Rep. 2018 10 23; 25(4):1018-1026.e4. Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. PMID: 30355481.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    38. Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell. 2018 10 18; 72(2):328-340.e8. Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R, Wang W. PMID: 30293781.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. Author Correction: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2018 Sep; 20(9):1098. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. PMID: 30018319.
      View in: PubMed   Mentions:    Fields:    
    40. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. 2018 08; 560(7720):655-660. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. PMID: 30135582.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    41. Interplay between YAP/TAZ and Metabolism. Cell Metab. 2018 08 07; 28(2):196-206. Koo JH, Guan KL. PMID: 30089241.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    42. Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma. Cell Rep. 2018 07 10; 24(2):463-478.e5. Akgül S, Li Y, Zheng S, Kool M, Treisman DM, Li C, Wang Y, Gröbner S, Ikenoue T, Shen Y, Camelo-Piragua S, Tomasek G, Stark S, Guduguntla V, Gusella JF, Guan KL, Pfister SM, Verhaak RGW, Zhu Y. PMID: 29996106.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    43. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 07 09; 9(1):2372. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. PMID: 29985391.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    44. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    45. Polycystic kidney disease: a Hippo connection. Genes Dev. 2018 06 01; 32(11-12):737-739. Ma S, Guan KL. PMID: 29921661.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    46. The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell. J Biol Chem. 2018 07 13; 293(28):11230-11240. Plouffe SW, Lin KC, Moore JL, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL. PMID: 29802201.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    47. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep. 2018 05; 19(5). Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D. PMID: 29491006.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    48. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018 02 06; 9(1):508. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX. PMID: 29410405.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    49. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 03 01; 128(3):970-984. Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z. PMID: 29400695.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    50. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene. 2018 03; 37(12):1637-1653. Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH, Yuan HX, Xiong Y. PMID: 29335519.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    51. The Hippo pathway in organ development, homeostasis, and regeneration. Curr Opin Cell Biol. 2017 12; 49:99-107. Fu V, Plouffe SW, Guan KL. PMID: 29316535.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    52. Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates. Trends Cancer. 2018 02; 4(2):151-165. Ye D, Guan KL, Xiong Y. PMID: 29458964.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    53. Colonic epithelium rejuvenation through YAP/TAZ. EMBO J. 2018 01 17; 37(2):164-166. Chen R, Guan KL. PMID: 29282206.
      View in: PubMed   Mentions:    Fields:    
    54. Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):856-868.e5. Cosset É, Ilmjärv S, Dutoit V, Elliott K, von Schalscha T, Camargo MF, Reiss A, Moroishi T, Seguin L, Gomez G, Moo JS, Preynat-Seauve O, Krause KH, Chneiweiss H, Sarkaria JN, Guan KL, Dietrich PY, Weis SM, Mischel PS, Cheresh DA. PMID: 29198914.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    55. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017 11; 284(21):3619-3636. Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, Yuan HX. PMID: 28886238.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    56. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 05; 68(1):198-209.e6. Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL. PMID: 28985504.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    57. Regulation of the Hippo Pathway Transcription Factor TEAD. Trends Biochem Sci. 2017 11; 42(11):862-872. Lin KC, Park HW, Guan KL. PMID: 28964625.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    58. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. PMID: 28752853.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    59. Non-radioactive LATS in vitro Kinase Assay. Bio Protoc. 2017 Jul 20; 7(14). Hong AW, Guan KL. PMID: 29104896.
      View in: PubMed   Mentions:
    60. DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7408-7413. Jin Y, Chen Y, Zhao S, Guan KL, Zhuang Y, Zhou W, Wu X, Xu T. PMID: 28645898.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    61. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. PMID: 28648777.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    62. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B. PMID: 28417999.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    63. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 04 15; 77(8):1997-2007. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL. PMID: 28381547.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    64. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017 04 15; 37(8). Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL. PMID: 28137912.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    65. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 04; 19(4):362-374. Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan KL, Xu P. PMID: 28346439.
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    192. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6474-9. Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL. PMID: 21464307.
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    193. Regulation of the autophagy initiating kinase ULK1 by nutrients: roles of mTORC1 and AMPK. Cell Cycle. 2011 May 01; 10(9):1337-8. Kim J, Guan KL. PMID: 21403467.
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    194. The ribosome and TORC2: collaborators for cell growth. Cell. 2011 Mar 04; 144(5):640-2. Xie X, Guan KL. PMID: 21376227.
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    195. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol. 2011 Mar; 13(3):263-72. Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J. PMID: 21336308.
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    196. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011 Feb; 13(2):132-41. Kim J, Kundu M, Viollet B, Guan KL. PMID: 21258367.
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    197. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell. 2011 Jan 21; 41(2):139-49. Hallows WC, Yu W, Smith BC, Devries MK, Devires MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. PMID: 21255725.
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    198. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18; 19(1):17-30. Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y. PMID: 21251613.
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    199. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 2011 Jan 01; 25(1):51-63. Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL. PMID: 21205866.
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    200. Amino acid signaling in TOR activation. Annu Rev Biochem. 2011; 80:1001-32. Kim J, Guan KL. PMID: 21548787.
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    201. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem. 2011 Feb 18; 286(7):5558-66. Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 21189257.
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    202. Hippo signaling at a glance. J Cell Sci. 2010 Dec 01; 123(Pt 23):4001-6. Zhao B, Li L, Guan KL. PMID: 21084559.
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    203. IDH1 mutant structures reveal a mechanism of dominant inhibition. Cell Res. 2010 Dec; 20(12):1279-81. Zhao S, Guan KL. PMID: 21079649.
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    204. Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci. 2011 Feb; 36(2):108-16. Guan KL, Xiong Y. PMID: 20934340.
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    205. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem. 2010 Nov 26; 285(48):37159-69. Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 20858893.
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    206. Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc. 2010 Sep; 5(9):1583-95. Guan KL, Yu W, Lin Y, Xiong Y, Zhao S. PMID: 21085124.
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    207. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16. Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. PMID: 20644257.
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    208. Regulation of Integrin ß 1 recycling to lipid rafts by Rab1a to promote cell migration. J Biol Chem. 2010 Sep 17; 285(38):29398-405. Wang C, Yoo Y, Fan H, Kim E, Guan KL, Guan JL. PMID: 20639577.
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    209. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death Differ. 2011 Jan; 18(1):133-44. Kang YJ, Lu MK, Guan KL. PMID: 20616807.
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    210. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010 Jun 01; 24(11):1106-18. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL. PMID: 20516196.
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    211. Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem. 2010 Jun 25; 285(26):19705-9. Li L, Kim E, Yuan H, Inoki K, Goraksha-Hicks P, Schiesher RL, Neufeld TP, Guan KL. PMID: 20457610.
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    212. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem. 2010 May 07; 285(19):14842. Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan KL, Wan Y. PMID: 29874310.
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    213. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev. 2010 May; 24(9):862-74. Zhao B, Li L, Lei Q, Guan KL. PMID: 20439427.
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    214. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science. 2010 Feb 19; 327(5968):1004-7. Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao S, Zhao GP. PMID: 20167787.
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    215. Regulation of cellular metabolism by protein lysine acetylation. Science. 2010 Feb 19; 327(5968):1000-4. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. PMID: 20167786.
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    216. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4153-8. Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. PMID: 20160076.
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    217. Structural insights into the YAP and TEAD complex. Genes Dev. 2010 Feb 01; 24(3):235-40. Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan KL, Xu Y. PMID: 20123905.
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    218. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev. 2010 Jan 01; 24(1):72-85. Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. PMID: 20048001.
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    219. Mst out and HCC in. Cancer Cell. 2009 Nov 06; 16(5):363-4. Zhao B, Lei Q, Guan KL. PMID: 19878866.
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    220. Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF. Mol Cell. 2009 Sep 11; 35(5):543-5. Li L, Guan KL. PMID: 19748348.
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    221. Critical roles for the TSC-mTOR pathway in ß-cell function. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1013-22. Mori H, Inoki K, Opland D, Münzberg H, Villanueva EC, Faouzi M, Ikenoue T, Kwiatkowski DJ, Macdougald OA, Myers MG, Guan KL. PMID: 19690069.
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    222. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med. 2009 Jun; 15(6):682-9. Chang J, Wang Z, Tang E, Fan Z, McCauley L, Franceschi R, Guan K, Krebsbach PH, Wang CY. PMID: 19448637.
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    223. Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8923-8. Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL. PMID: 19458266.
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    224. The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. Biochem Biophys Res Commun. 2009 Jul 10; 384(4):471-5. Mori H, Inoki K, Masutani K, Wakabayashi Y, Komai K, Nakagawa R, Guan KL, Yoshimura A. PMID: 19422788.
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    225. Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet. 2009 Apr 15; 18(R1):R94-100. Inoki K, Guan KL. PMID: 19297407.
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    226. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009 Apr 10; 324(5924):261-5. Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y. PMID: 19359588.
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    227. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab. 2009 Apr; 9(4):362-74. Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG, Guan KL. PMID: 19356717.
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    228. RAG GTPases in nutrient-mediated TOR signaling pathway. Cell Cycle. 2009 Apr 01; 8(7):1014-8. Kim E, Guan KL. PMID: 19270521.
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    229. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009 May 15; 284(20):13355-62. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. PMID: 19324877.
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    230. Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem. 2009 May 15; 284(20):13669-75. Yu W, Lin Y, Yao J, Huang W, Lei Q, Xiong Y, Zhao S, Guan KL. PMID: 19318352.
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    231. Harness the power: new insights into the inhibition of YAP/Yorkie. Dev Cell. 2009 Mar; 16(3):321-2. Zhao B, Lei QY, Guan KL. PMID: 19289076.
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    232. AMP-activated protein kinase and cancer. Acta Physiol (Oxf). 2009 May; 196(1):55-63. Wang W, Guan KL. PMID: 19243571.
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    233. DSCAM functions as a netrin receptor in commissural axon pathfinding. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2951-6. Liu G, Li W, Wang L, Kar A, Guan KL, Rao Y, Wu JY. PMID: 19196994.
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    234. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res. 2009 Feb 01; 69(3):1089-98. Zhao B, Kim J, Ye X, Lai ZC, Guan KL. PMID: 19141641.
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    235. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol. 2008 Dec; 20(6):638-46. Zhao B, Lei QY, Guan KL. PMID: 18955139.
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    236. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 2008 Sep 29; 205(10):2397-408. Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. PMID: 18809716.
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    237. PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 2008 Sep 01; 68(17):6908-12. Ikenoue T, Inoki K, Zhao B, Guan KL. PMID: 18757404.
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    238. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem. 2008 Oct 24; 283(43):28897-908. Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan KL, Wan Y. PMID: 18715874.
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    239. A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C836-43. Buller CL, Loberg RD, Fan MH, Zhu Q, Park JL, Vesely E, Inoki K, Guan KL, Brosius FC. PMID: 18650261.
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    240. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol. 2008 Aug; 10(8):935-45. Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL. PMID: 18604198.
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    241. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008 Jul 15; 22(14):1962-71. Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang CY, Chinnaiyan AM, Lai ZC, Guan KL. PMID: 18579750.
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    242. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23; 27(14):1919-31. Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. PMID: 18566587.
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    243. Substrate selectivity APPLies to Akt. Cell. 2008 May 02; 133(3):399-400. Zhao S, Guan KL. PMID: 18455980.
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    244. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol. 2008 Apr; 28(7):2426-36. Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL. PMID: 18227151.
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    245. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007 Nov 01; 21(21):2747-61. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL. PMID: 17974916.
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    246. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 2007 Nov 28; 26(23):4812-23. Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan KL. PMID: 17962806.
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    247. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem. 2007 Dec 07; 282(49):35803-13. Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, Guan KL. PMID: 17928295.
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    248. Expanding mTOR signaling. Cell Res. 2007 Aug; 17(8):666-81. Yang Q, Guan KL. PMID: 17680028.
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    249. p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci. 2007 Jan 24; 27(4):957-68. Liu G, Li W, Gao X, Li X, Jürgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan KL, Rao Y. PMID: 17251438.
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    250. Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem. 2007 Mar 16; 282(11):7991-6. Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan KL, Dong LQ, Liu F. PMID: 17244624.
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    251. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol. 2007; 47:443-67. Lee CH, Inoki K, Guan KL. PMID: 16968213.
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    252. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15; 20(20):2820-32. Yang Q, Inoki K, Ikenoue T, Guan KL. PMID: 17043309.
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    253. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett. 2006 Oct 16; 580(24):5621-7. Wan M, Wu X, Guan KL, Han M, Zhuang Y, Xu T. PMID: 16996505.
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    254. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006 Sep 08; 126(5):955-68. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL. PMID: 16959574.
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    256. Complexity of the TOR signaling network. Trends Cell Biol. 2006 Apr; 16(4):206-12. Inoki K, Guan KL. PMID: 16516475.
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    257. Semaphorin 4D activates the MAPK pathway downstream of plexin-B1. Biochem J. 2006 Mar 01; 394(Pt 2):459-64. Aurandt J, Li W, Guan KL. PMID: 16187944.
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    260. FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. J Cell Sci. 2006 Jan 01; 119(Pt 1):47-55. Li W, Aurandt J, Jürgensen C, Jürgense C, Rao Y, Guan KL. PMID: 16371650.
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    264. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev. 2005 Mar; 69(1):79-100. Inoki K, Ouyang H, Li Y, Guan KL. PMID: 15755954.
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