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Kun-Liang Guan

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-822-7945
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Ph.D.Purdue University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanism and Therapy for Ocular Melanoma
    NIH/NCI R01CA217642Mar 14, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    The mTOR and Hippo pathway in cell growth and cancer
    NIH/NCI R35CA196878Aug 5, 2015 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of the Hippo pathway and its role in uveal melanoma
    NIH/NEI R01EY022611Sep 1, 2012 - Aug 31, 2016
    Role: Principal Investigator
    Regulation and function of the YAP transcription co-activator oncoprotein
    NIH/NCI R01CA132809Apr 8, 2008 - Feb 28, 2018
    Role: Principal Investigator
    Rag GTPases in mTOR regulation and physiological functions
    NIH/NCI R01CA108941Sep 3, 2004 - Jun 30, 2019
    Role: Principal Investigator
    S6K and mTOR as targets for tuberous sclerosis
    NIH/NCI R41CA101611Jul 1, 2003 - Jun 30, 2004
    Role: Principal Investigator
    Regulation of Ras and Rheb modification by GCN2
    NIH/NIGMS R01GM062694Jul 1, 2000 - Jun 30, 2012
    Role: Principal Investigator
    REGULATION OF PROTEIN TYROSINE PHOSPHORYLATION IN YEAST
    NIH/NIGMS R01GM055642May 1, 1997 - Apr 30, 2001
    Role: Principal Investigator
    Protein phosphorylation and growth factor function
    NIH/NIGMS R01GM051586Aug 1, 1994 - Nov 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Plouffe SW, Lin KC, Moore JL, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan K. The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell. J Biol Chem. 2018 May 25. PMID: 29802201.
      View in: PubMed
    2. Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan K, Ye D. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep. 2018 May; 19(5). PMID: 29491006.
      View in: PubMed
    3. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan K, Yuan HX. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018 Feb 06; 9(1):508. PMID: 29410405.
      View in: PubMed
    4. Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 Mar 01; 128(3):970-984. PMID: 29400695.
      View in: PubMed
    5. Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan K, Shi YH, Yuan HX, Xiong Y. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene. 2018 Mar; 37(12):1637-1653. PMID: 29335519.
      View in: PubMed
    6. Fu V, Plouffe SW, Guan K. The Hippo pathway in organ development, homeostasis, and regeneration. Curr Opin Cell Biol. 2017 Dec; 49:99-107. PMID: 29316535.
      View in: PubMed
    7. Ye D, Guan K, Xiong Y. Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates. Trends Cancer. 2018 Feb; 4(2):151-165. PMID: 29458964.
      View in: PubMed
    8. Chen R, Guan K. Colonic epithelium rejuvenation through YAP/TAZ. EMBO J. 2018 Jan 17; 37(2):164-166. PMID: 29282206.
      View in: PubMed
    9. Cosset É, Ilmjärv S, Dutoit V, Elliott K, von Schalscha T, Camargo MF, Reiss A, Moroishi T, Seguin L, Gomez G, Moo JS, Preynat-Seauve O, Krause KH, Chneiweiss H, Sarkaria JN, Guan K, Dietrich PY, Weis SM, Mischel PS, Cheresh DA. Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):856-868.e5. PMID: 29198914.
      View in: PubMed
    10. Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan K, Yuan HX. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017 11; 284(21):3619-3636. PMID: 28886238.
      View in: PubMed
    11. Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan K. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell. 2017 Oct 05; 68(1):198-209.e6. PMID: 28985504.
      View in: PubMed
    12. Lin KC, Park HW, Guan K. Regulation of the Hippo Pathway Transcription Factor TEAD. Trends Biochem Sci. 2017 11; 42(11):862-872. PMID: 28964625.
      View in: PubMed
    13. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan K. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002. PMID: 28752853.
      View in: PubMed
    14. Hong AW, Guan K. Non-radioactive LATS in vitro Kinase Assay. Bio Protoc. 2017 Jul 20; 7(14). PMID: 29104896.
      View in: PubMed
    15. Jin Y, Chen Y, Zhao S, Guan K, Zhuang Y, Zhou W, Wu X, Xu T. DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7408-7413. PMID: 28645898.
      View in: PubMed
    16. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan K, Mischel PS. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. PMID: 28648777.
      View in: PubMed
    17. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan K, Ren B. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635. PMID: 28417999.
      View in: PubMed
    18. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan K, Klemke RL. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 04 15; 77(8):1997-2007. PMID: 28381547.
      View in: PubMed
    19. Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan K. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017 Apr 15; 37(8). PMID: 28137912.
      View in: PubMed
    20. Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan K, Xu P. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 04; 19(4):362-374. PMID: 28346439.
      View in: PubMed
    21. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan K. Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Res. 2017 05 01; 77(9):2413-2423. PMID: 28249901.
      View in: PubMed
    22. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan K, Haybaeck J, Datz C, Zhang K, Karin M. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648. PMID: 28130546.
      View in: PubMed
    23. Ma X, Zhang S, He L, Rong Y, Brier LW, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan K, Li D, Zhong Q. MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 2017 Mar 04; 13(3):592-607. PMID: 28059666.
      View in: PubMed
    24. Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan K. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep. 2017 01; 18(1):72-86. PMID: 27979971.
      View in: PubMed
    25. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan K. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. PMID: 27912060.
      View in: PubMed
    26. Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV, Guan K. Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell. 2016 Dec 01; 64(5):993-1008. PMID: 27912098.
      View in: PubMed
    27. Lin HP, Cheng ZL, He RY, Song L, Tian MX, Zhou LS, Groh BS, Liu WR, Ji MB, Ding C, Shi YH, Guan K, Ye D, Xiong Y. Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. Cancer Res. 2016 12 01; 76(23):6924-6936. PMID: 27758890.
      View in: PubMed
    28. Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan K, Li YJ, Chien S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11525-11530. PMID: 27671657.
      View in: PubMed
    29. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng Z, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan K. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 09 02; 291(36):18947-58. PMID: 27382053; PMCID: PMC5009267 [Available on 09/02/17].
      View in: PubMed, PubMed Central
    30. Hong AW, Meng Z, Guan K. The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol. 2016 06; 13(6):324-37. PMID: 27147489.
      View in: PubMed
    31. Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XH, Guan K, Zou J, Xu P. Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes Dev. 2016 05 01; 30(9):1086-100. PMID: 27125670; PMCID: PMC4863739 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    32. Zha Z, Han XR, Smith MD, Lei QY, Guan K, Xiong Y. Hypertension-associated C825T polymorphism impairs the function of Gß3 to target GRK2 ubiquitination. Cell Discov. 2016; 2:16005. PMID: 27462452; PMCID: PMC4849471.
      View in: PubMed, PubMed Central
    33. Fu V, Moroishi T, Guan K. Glycoholics Anonymous: Cancer Sobers Up with mTORC1. Cancer Cell. 2016 Apr 11; 29(4):432-434. PMID: 27070696.
      View in: PubMed
    34. Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan K, Yang P, Yu H, Ye D. SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Rep. 2016 06; 17(6):811-22. PMID: 27113762.
      View in: PubMed
    35. Diao Y, Li B, Meng Z, Jung I, Lee AY, Dixon J, Maliskova L, Guan K, Shen Y, Ren B. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 2016 Mar; 26(3):397-405. PMID: 26813977; PMCID: PMC4772021.
      View in: PubMed, PubMed Central
    36. Yuan HX, Guan K. Structural insights of mTOR complex 1. Cell Res. 2016 Mar; 26(3):267-8. PMID: 26794870; PMCID: PMC4783463 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    37. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    38. Meng Z, Moroishi T, Guan K. Mechanisms of Hippo pathway regulation. Genes Dev. 2016 Jan 01; 30(1):1-17. PMID: 26728553; PMCID: PMC4701972.
      View in: PubMed, PubMed Central
    39. Wang P, Wu J, Ma S, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan K, Ye D, Xiong Y. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22; 13(11):2353-2361. PMID: 26686626; PMCID: PMC4694633.
      View in: PubMed, PubMed Central
    40. Hansen CG, Ng YL, Lam WL, Plouffe SW, Guan K. The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Res. 2015 Dec; 25(12):1299-313. PMID: 26611634; PMCID: PMC4670996 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    41. Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan K. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev. 2015 Nov 15; 29(22):2362-76. PMID: 26588989; PMCID: PMC4691891.
      View in: PubMed, PubMed Central
    42. Yu FX, Zhao B, Guan K. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 2015 Nov 05; 163(4):811-28. PMID: 26544935; PMCID: PMC4638384 [Available on 11/05/16].
      View in: PubMed, PubMed Central
    43. Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan K. Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015 Nov; 13(11):e1002287. PMID: 26539968; PMCID: PMC4634850.
      View in: PubMed, PubMed Central
    44. Yuan HX, Guan K. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015 Nov; 5(11):1127-9. PMID: 26526694; PMCID: PMC4638136.
      View in: PubMed, PubMed Central
    45. Ma T, Li J, Xu Y, Yu C, Xu T, Wang H, Liu K, Cao N, Nie BM, Zhu SY, Xu S, Li K, Wei WG, Wu Y, Guan K, Ding S. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nat Cell Biol. 2015 Nov; 17(11):1379-87. PMID: 26502054.
      View in: PubMed
    46. Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HW, Mo JS, Lu W, Lu S, Flores F, Yu FX, Halder G, Guan K. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015 Oct 05; 6:8357. PMID: 26437443; PMCID: PMC4600732.
      View in: PubMed, PubMed Central
    47. Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan K, Pende M, Panasyuk G. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015 Sep 21; 6:8283. PMID: 26387534; PMCID: PMC4579570.
      View in: PubMed, PubMed Central
    48. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan K, Karin M, Hee Lee J. Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Sep 21; 5:14029. PMID: 26390293; PMCID: PMC4642703.
      View in: PubMed, PubMed Central
    49. Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan K. Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015; 13(9):e1002243. PMID: 26356530; PMCID: PMC4565669.
      View in: PubMed, PubMed Central
    50. Ha J, Guan K, Kim J. AMPK and autophagy in glucose/glycogen metabolism. Mol Aspects Med. 2015 Dec; 46:46-62. PMID: 26297963.
      View in: PubMed
    51. Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan K. Alternative Wnt Signaling Activates YAP/TAZ. Cell. 2015 Aug 13; 162(4):780-94. PMID: 26276632; PMCID: PMC4538707.
      View in: PubMed, PubMed Central
    52. Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX, Xu Y, Guan K. Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Cell Res. 2015 Aug; 25(8):985-8. PMID: 26206313; PMCID: PMC4528059.
      View in: PubMed, PubMed Central
    53. Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan K. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015 Aug; 16(8):975-85. PMID: 26116754; PMCID: PMC4552490.
      View in: PubMed, PubMed Central
    54. Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan K. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84. PMID: 26109050; PMCID: PMC4495398.
      View in: PubMed, PubMed Central
    55. Hansen CG, Moroishi T, Guan K. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol. 2015 Sep; 25(9):499-513. PMID: 26045258; PMCID: PMC4554827.
      View in: PubMed, PubMed Central
    56. Qi Q, Li DY, Luo HR, Guan K, Ye K. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7255-60. PMID: 26039999; PMCID: PMC4466726.
      View in: PubMed, PubMed Central
    57. Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan K, Lei QY, Xiong Y. A Non-Canonical Function of Gß as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Mol Cell. 2015 Jun 04; 58(5):794-803. PMID: 25982117; PMCID: PMC4458238.
      View in: PubMed, PubMed Central
    58. Zhou X, Wang S, Wang Z, Feng X, Liu P, Lv XB, Li F, Yu FX, Sun Y, Yuan H, Zhu H, Xiong Y, Lei QY, Guan K. Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest. 2015 May; 125(5):2123-35. PMID: 25893606; PMCID: PMC4463207.
      View in: PubMed, PubMed Central
    59. Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan K. D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarget. 2015 Apr 20; 6(11):8606-20. PMID: 25825982; PMCID: PMC4496170.
      View in: PubMed, PubMed Central
    60. Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan K. Corrigendum: inhibition of a-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2015 Apr 15; 29(8):887. PMID: 25877923; PMCID: PMC4403263.
      View in: PubMed, PubMed Central
    61. Zhou Q, Li L, Zhao B, Guan K. The hippo pathway in heart development, regeneration, and diseases. Circ Res. 2015 Apr 10; 116(8):1431-47. PMID: 25858067; PMCID: PMC4394208.
      View in: PubMed, PubMed Central
    62. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan K, Karin M, Lee JH. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Mar 30; 5:9502. PMID: 25819761; PMCID: PMC4377584.
      View in: PubMed, PubMed Central
    63. Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan K. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015 Apr; 17(4):500-10. PMID: 25751140; PMCID: PMC4380774.
      View in: PubMed, PubMed Central
    64. Yang H, Zhou L, Shi Q, Zhao Y, Lin H, Zhang M, Zhao S, Yang Y, Ling ZQ, Guan K, Xiong Y, Ye D. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO J. 2015 Apr 15; 34(8):1110-25. PMID: 25755250; PMCID: PMC4406655.
      View in: PubMed, PubMed Central
    65. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan K, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. PMID: 25731159; PMCID: PMC4447318.
      View in: PubMed, PubMed Central
    66. Jewell JL, Flores F, Guan K. Micro(RNA) managing by mTORC1. Mol Cell. 2015 Feb 19; 57(4):575-576. PMID: 25699705.
      View in: PubMed
    67. Plouffe SW, Hong AW, Guan K. Disease implications of the Hippo/YAP pathway. Trends Mol Med. 2015 Apr; 21(4):212-22. PMID: 25702974; PMCID: PMC4385444.
      View in: PubMed, PubMed Central
    68. Moroishi T, Hansen CG, Guan K. The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer. 2015 Feb; 15(2):73-79. PMID: 25592648; PMCID: PMC4562315.
      View in: PubMed, PubMed Central
    69. Wang Y, Xiao M, Chen X, Chen L, Xu Y, Lv L, Wang P, Yang H, Ma S, Lin H, Jiao B, Ren R, Ye D, Guan K, Xiong Y. WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell. 2015 Feb 19; 57(4):662-673. PMID: 25601757.
      View in: PubMed
    70. Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan K. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015 Jan 09; 347(6218):194-8. PMID: 25567907; PMCID: PMC4384888.
      View in: PubMed, PubMed Central
    71. Kim YC, Guan K. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015 Jan; 125(1):25-32. PMID: 25654547; PMCID: PMC4382265.
      View in: PubMed, PubMed Central
    72. Vikis HG, Guan K. Glutathione-S-transferase (GST)-fusion based assays for studying protein-protein interactions. Methods Mol Biol. 2015; 1278:353-64. PMID: 25859961.
      View in: PubMed
    73. Lyubasyuk V, Ouyang H, Yu FX, Guan K, Zhang K. YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations. Mol Cell Oncol. 2015 Jan-Mar; 2(1):e970957. PMID: 27308390; PMCID: PMC4905245.
      View in: PubMed, PubMed Central
    74. Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan K, Karin M, Budanov AV. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20; 9(4):1281-91. PMID: 25457612; PMCID: PMC4303546.
      View in: PubMed, PubMed Central
    75. Zhao D, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y, Guan K, Lei QY. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014 Dec; 124(12):5453-65. PMID: 25384215; PMCID: PMC4348941.
      View in: PubMed, PubMed Central
    76. Yu FX, Meng Z, Plouffe SW, Guan K. Hippo pathway regulation of gastrointestinal tissues. Annu Rev Physiol. 2015; 77:201-27. PMID: 25293527.
      View in: PubMed
    77. Zhao B, Guan K. Hippo pathway key to ploidy checkpoint. Cell. 2014 Aug 14; 158(4):695-696. PMID: 25126776.
      View in: PubMed
    78. Gao Y, Zhang W, Han X, Li F, Wang X, Wang R, Fang Z, Tong X, Yao S, Li F, Feng Y, Sun Y, Hou Y, Yang Z, Guan K, Chen H, Zhang L, Ji H. YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nat Commun. 2014 Aug 13; 5:4629. PMID: 25115923.
      View in: PubMed
    79. Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan K. Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun. 2014 Jul 01; 5:4241. PMID: 24980141; PMCID: PMC4100214.
      View in: PubMed, PubMed Central
    80. Yang H, Lin H, Xu H, Zhang L, Cheng L, Wen B, Shou J, Guan K, Xiong Y, Ye D. TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Res. 2014 Aug; 24(8):1017-20. PMID: 24971736; PMCID: PMC4123294.
      View in: PubMed, PubMed Central
    81. Yu FX, Zhang K, Guan K. YAP as oncotarget in uveal melanoma. Oncoscience. 2014; 1(7):480-1. PMID: 25594048; PMCID: PMC4278320.
      View in: PubMed, PubMed Central
    82. Luk JM, Guan K. An alternative DNA damage pathway to apoptosis in hematological cancers. Nat Med. 2014 Jun; 20(6):587-8. PMID: 24901566.
      View in: PubMed
    83. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan K. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30. PMID: 24882516; PMCID: PMC4075337.
      View in: PubMed, PubMed Central
    84. Mo JS, Park HW, Guan K. The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep. 2014 Jun; 15(6):642-56. PMID: 24825474; PMCID: PMC4197875.
      View in: PubMed, PubMed Central
    85. Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan K, Lei QY, Xiong Y. Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Res. 2014 Jul 01; 74(13):3630-42. PMID: 24786789; PMCID: PMC4303242.
      View in: PubMed, PubMed Central
    86. Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan K, Ye D. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 2014 Jun 17; 33(12):1304-20. PMID: 24769394; PMCID: PMC4194121.
      View in: PubMed, PubMed Central
    87. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan K, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 08; 54(3):378-91. PMID: 24703948; PMCID: PMC4019712.
      View in: PubMed, PubMed Central
    88. Yu FX, Guan K. Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway. EMBO J. 2014 May 02; 33(9):942-4. PMID: 24639555; PMCID: PMC4193929.
      View in: PubMed, PubMed Central
    89. Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A, Sugiarto S, Garner M, Paik J, DePinho RA, Goldman D, Guan K, Shrager JB. mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases. Sci Signal. 2014 Feb 25; 7(314):ra18. PMID: 24570486.
      View in: PubMed
    90. Lin R, Zhou X, Huang W, Zhao D, Lv L, Xiong Y, Guan K, Lei QY. Acetylation control of cancer cell metabolism. Curr Pharm Des. 2014; 20(15):2627-33. PMID: 23859620.
      View in: PubMed
    91. Li T, Liu M, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan K, Xiong Y, Lei QY. Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal. J Biol Chem. 2014 Feb 07; 289(6):3775-85. PMID: 24362262; PMCID: PMC3916574.
      View in: PubMed, PubMed Central
    92. Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan K, Wang CY. LATS2 suppresses oncogenic Wnt signaling by disrupting ß-catenin/BCL9 interaction. Cell Rep. 2013 Dec 26; 5(6):1650-63. PMID: 24360964; PMCID: PMC3897473.
      View in: PubMed, PubMed Central
    93. Russell RC, Yuan HX, Guan K. Autophagy regulation by nutrient signaling. Cell Res. 2014 Jan; 24(1):42-57. PMID: 24343578; PMCID: PMC3879708.
      View in: PubMed, PubMed Central
    94. Yuan HX, Russell RC, Guan K. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy. 2013 Dec; 9(12):1983-95. PMID: 24013218; PMCID: PMC4028342.
      View in: PubMed, PubMed Central
    95. Yang H, Xiong Y, Guan K. Metabolic alteration in tumorigenesis. Sci China Life Sci. 2013 Dec; 56(12):1067-75. PMID: 24114443.
      View in: PubMed
    96. Lv L, Xu YP, Zhao D, Li FL, Wang W, Sasaki N, Jiang Y, Zhou X, Li TT, Guan K, Lei QY, Xiong Y. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell. 2013 Nov 07; 52(3):340-52. PMID: 24120661; PMCID: PMC4183148.
      View in: PubMed, PubMed Central
    97. Dai X, She P, Chi F, Feng Y, Liu H, Jin D, Zhao Y, Guo X, Jiang D, Guan K, Zhong TP, Zhao B. Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. J Biol Chem. 2013 Nov 22; 288(47):34041-51. PMID: 24106267; PMCID: PMC3837143.
      View in: PubMed, PubMed Central
    98. Park HW, Guan K. Regulation of the Hippo pathway and implications for anticancer drug development. Trends Pharmacol Sci. 2013 Oct; 34(10):581-9. PMID: 24051213; PMCID: PMC3929107.
      View in: PubMed, PubMed Central
    99. Lin R, Tao R, Gao X, Li T, Zhou X, Guan K, Xiong Y, Lei QY. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22; 51(4):506-518. PMID: 23932781; PMCID: PMC4180208.
      View in: PubMed, PubMed Central
    100. Zhao D, Xiong Y, Lei QY, Guan K. LDH-A acetylation: implication in cancer. Oncotarget. 2013 Jun; 4(6):802-3. PMID: 23868819; PMCID: PMC3757233.
      View in: PubMed, PubMed Central
    101. Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan K. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013 Jun 01; 27(11):1223-32. PMID: 23752589; PMCID: PMC3690396.
      View in: PubMed, PubMed Central
    102. Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan K. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol. 2013 Jul; 15(7):741-50. PMID: 23685627; PMCID: PMC3885611.
      View in: PubMed, PubMed Central
    103. Kim J, Guan K. AMPK connects energy stress to PIK3C3/VPS34 regulation. Autophagy. 2013 Jul; 9(7):1110-1. PMID: 23669030; PMCID: PMC3722323.
      View in: PubMed, PubMed Central
    104. Nemazanyy I, Blaauw B, Paolini C, Caillaud C, Protasi F, Mueller A, Proikas-Cezanne T, Russell RC, Guan K, Nishino I, Sandri M, Pende M, Panasyuk G. Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease. EMBO Mol Med. 2013 Jun; 5(6):870-90. PMID: 23630012; PMCID: PMC3779449.
      View in: PubMed, PubMed Central
    105. Zhao D, Zou SW, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y, Lei QY, Guan K. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell. 2013 Apr 15; 23(4):464-76. PMID: 23523103; PMCID: PMC3885615.
      View in: PubMed, PubMed Central
    106. Ye D, Ma S, Xiong Y, Guan K. R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis. Cancer Cell. 2013 Mar 18; 23(3):274-6. PMID: 23518346; PMCID: PMC3652525.
      View in: PubMed, PubMed Central
    107. Jewell JL, Guan K. Nutrient signaling to mTOR and cell growth. Trends Biochem Sci. 2013 May; 38(5):233-42. PMID: 23465396; PMCID: PMC3634910.
      View in: PubMed, PubMed Central
    108. Yu FX, Guan K. The Hippo pathway: regulators and regulations. Genes Dev. 2013 Feb 15; 27(4):355-71. PMID: 23431053; PMCID: PMC3589553.
      View in: PubMed, PubMed Central
    109. Yuan HX, Xiong Y, Guan K. Nutrient sensing, metabolism, and cell growth control. Mol Cell. 2013 Feb 07; 49(3):379-87. PMID: 23395268; PMCID: PMC3587157.
      View in: PubMed, PubMed Central
    110. Jewell JL, Russell RC, Guan K. Amino acid signalling upstream of mTOR. Nat Rev Mol Cell Biol. 2013 Mar; 14(3):133-9. PMID: 23361334; PMCID: PMC3988467.
      View in: PubMed, PubMed Central
    111. Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q, Guan K. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 2013 Jan 17; 152(1-2):290-303. PMID: 23332761; PMCID: PMC3587159.
      View in: PubMed, PubMed Central
    112. Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan K. YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol. 2012 Dec; 14(12):1322-9. PMID: 23143395; PMCID: PMC4019071.
      View in: PubMed, PubMed Central
    113. Li L, Guan K. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem. 2013 Jan 04; 288(1):703-8. PMID: 23184942; PMCID: PMC3537069.
      View in: PubMed, PubMed Central
    114. Yu FX, Mo JS, Guan K. Upstream regulators of the Hippo pathway. Cell Cycle. 2012 Nov 15; 11(22):4097-8. PMID: 23075495; PMCID: PMC3524194.
      View in: PubMed, PubMed Central
    115. Yang H, Ye D, Guan K, Xiong Y. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin Cancer Res. 2012 Oct 15; 18(20):5562-71. PMID: 23071358; PMCID: PMC3897211.
      View in: PubMed, PubMed Central
    116. Mo JS, Yu FX, Gong R, Brown JH, Guan K. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev. 2012 Oct 01; 26(19):2138-43. PMID: 22972936; PMCID: PMC3465735.
      View in: PubMed, PubMed Central
    117. Magee JA, Ikenoue T, Nakada D, Lee JY, Guan K, Morrison SJ. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012 Sep 07; 11(3):415-28. PMID: 22958933; PMCID: PMC3447536.
      View in: PubMed, PubMed Central
    118. Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan K. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17; 150(4):780-91. PMID: 22863277; PMCID: PMC3433174.
      View in: PubMed, PubMed Central
    119. Xiong Y, Guan K. Mechanistic insights into the regulation of metabolic enzymes by acetylation. J Cell Biol. 2012 Jul 23; 198(2):155-64. PMID: 22826120; PMCID: PMC3410420.
      View in: PubMed, PubMed Central
    120. Tang F, Wu Q, Ikenoue T, Guan K, Liu Y, Zheng P. A critical role for Rictor in T lymphopoiesis. J Immunol. 2012 Aug 15; 189(4):1850-7. PMID: 22815285; PMCID: PMC3412163.
      View in: PubMed, PubMed Central
    121. Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan K. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFß-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2012 Jul 27; 287(31):26245-53. PMID: 22692215; PMCID: PMC3406709.
      View in: PubMed, PubMed Central
    122. Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan K, Liu G. Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. J Biol Chem. 2012 Aug 03; 287(32):27126-38. PMID: 22685302; PMCID: PMC3411055.
      View in: PubMed, PubMed Central
    123. Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan K. Inhibition of a-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2012 Jun 15; 26(12):1326-38. PMID: 22677546; PMCID: PMC3387660.
      View in: PubMed, PubMed Central
    124. Hong W, Guan K. The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. Semin Cell Dev Biol. 2012 Sep; 23(7):785-93. PMID: 22659496; PMCID: PMC3459069.
      View in: PubMed, PubMed Central
    125. Tumaneng K, Russell RC, Guan K. Organ size control by Hippo and TOR pathways. Curr Biol. 2012 May 08; 22(9):R368-79. PMID: 22575479; PMCID: PMC3601681.
      View in: PubMed, PubMed Central
    126. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
      View in: PubMed
    127. Ye D, Xiong Y, Guan K. The mechanisms of IDH mutations in tumorigenesis. Cell Res. 2012 Jul; 22(7):1102-4. PMID: 22453240; PMCID: PMC3391014.
      View in: PubMed, PubMed Central
    128. Valbuena N, Guan K, Moreno S. The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. J Cell Sci. 2012 Apr 15; 125(Pt 8):1920-8. PMID: 22344254; PMCID: PMC3656621.
      View in: PubMed, PubMed Central
    129. Oermann EK, Wu J, Guan K, Xiong Y. Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol. 2012 Jun; 23(4):370-80. PMID: 22306135; PMCID: PMC3351496.
      View in: PubMed, PubMed Central
    130. Zhang T, Wang S, Lin Y, Xu W, Ye D, Xiong Y, Zhao S, Guan K. Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab. 2012 Jan 04; 15(1):75-87. PMID: 22225877; PMCID: PMC3285296.
      View in: PubMed, PubMed Central
    131. Zhao B, Li L, Wang L, Wang CY, Yu J, Guan K. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev. 2012 Jan 01; 26(1):54-68. PMID: 22215811; PMCID: PMC3258966.
      View in: PubMed, PubMed Central
    132. Zhou X, Li TT, Feng X, Hsiang E, Xiong Y, Guan K, Lei QY. Targeted polyubiquitylation of RASSF1C by the Mule and SCFß-TrCP ligases in response to DNA damage. Biochem J. 2012 Jan 01; 441(1):227-36. PMID: 21910689; PMCID: PMC4610364.
      View in: PubMed, PubMed Central
    133. Mori H, Guan K. Tissue-specific ablation of Tsc1 in pancreatic beta-cells. Methods Mol Biol. 2012; 821:407-19. PMID: 22125081.
      View in: PubMed
    134. Inoki K, Kim J, Guan K. AMPK and mTOR in cellular energy homeostasis and drug targets. Annu Rev Pharmacol Toxicol. 2012; 52:381-400. PMID: 22017684.
      View in: PubMed
    135. Lu MK, Gong XG, Guan K. mTOR in podocyte function: is rapamycin good for diabetic nephropathy? Cell Cycle. 2011 Oct 15; 10(20):3415-6. PMID: 22067710; PMCID: PMC3266173.
      View in: PubMed, PubMed Central
    136. Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan K, Xu Y. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes Dev. 2011 Aug 15; 25(16):1668-73. PMID: 21816923; PMCID: PMC3165931.
      View in: PubMed, PubMed Central
    137. Russell RC, Fang C, Guan K. An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development. 2011 Aug; 138(16):3343-56. PMID: 21791526; PMCID: PMC3143559.
      View in: PubMed, PubMed Central
    138. Zhao B, Tumaneng K, Guan K. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol. 2011 Aug 01; 13(8):877-83. PMID: 21808241; PMCID: PMC3987945.
      View in: PubMed, PubMed Central
    139. Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan K, Inoki K. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. J Biol Chem. 2011 Sep 16; 286(37):32651-60. PMID: 21784859; PMCID: PMC3173157.
      View in: PubMed, PubMed Central
    140. Jiang W, Wang S, Xiao M, Lin Y, Zhou L, Lei Q, Xiong Y, Guan K, Zhao S. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell. 2011 Jul 08; 43(1):33-44. PMID: 21726808; PMCID: PMC3962309.
      View in: PubMed, PubMed Central
    141. Wu Q, Liu Y, Chen C, Ikenoue T, Qiao Y, Li CS, Li W, Guan K, Liu Y, Zheng P. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J Immunol. 2011 Aug 01; 187(3):1106-12. PMID: 21709159.
      View in: PubMed
    142. Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan K, Lei QY. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell. 2011 Jun 24; 42(6):719-30. PMID: 21700219; PMCID: PMC4879880.
      View in: PubMed, PubMed Central
    143. Egan D, Kim J, Shaw RJ, Guan K. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy. 2011 Jun; 7(6):643-4. PMID: 21460621; PMCID: PMC3359466.
      View in: PubMed, PubMed Central
    144. Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan K. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest. 2011 Jun; 121(6):2181-96. PMID: 21606597; PMCID: PMC3104745.
      View in: PubMed, PubMed Central
    145. Chen Y, Zhang J, Lin Y, Lei Q, Guan K, Zhao S, Xiong Y. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep. 2011 Jun; 12(6):534-41. PMID: 21566644; PMCID: PMC3128277.
      View in: PubMed, PubMed Central
    146. Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan K. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6474-9. PMID: 21464307; PMCID: PMC3081021.
      View in: PubMed, PubMed Central
    147. Kim J, Guan K. Regulation of the autophagy initiating kinase ULK1 by nutrients: roles of mTORC1 and AMPK. Cell Cycle. 2011 May 01; 10(9):1337-8. PMID: 21403467.
      View in: PubMed
    148. Xie X, Guan K. The ribosome and TORC2: collaborators for cell growth. Cell. 2011 Mar 04; 144(5):640-2. PMID: 21376227; PMCID: PMC3285269.
      View in: PubMed, PubMed Central
    149. Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan K, Han J. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol. 2011 Mar; 13(3):263-72. PMID: 21336308; PMCID: PMC3070924.
      View in: PubMed, PubMed Central
    150. Kim J, Kundu M, Viollet B, Guan K. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011 Feb; 13(2):132-41. PMID: 21258367; PMCID: PMC3987946.
      View in: PubMed, PubMed Central
    151. Hallows WC, Yu W, Smith BC, Devries MK, Devires MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan K, Denu JM. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell. 2011 Jan 21; 41(2):139-49. PMID: 21255725.
      View in: PubMed
    152. Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan K, Zhao SM, Xiong Y. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18; 19(1):17-30. PMID: 21251613; PMCID: PMC3229304.
      View in: PubMed, PubMed Central
    153. Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan K. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 2011 Jan 01; 25(1):51-63. PMID: 21205866; PMCID: PMC3012936.
      View in: PubMed, PubMed Central
    154. Kim J, Guan K. Amino acid signaling in TOR activation. Annu Rev Biochem. 2011; 80:1001-32. PMID: 21548787.
      View in: PubMed
    155. Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY, Guan K. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem. 2011 Feb 18; 286(7):5558-66. PMID: 21189257; PMCID: PMC3037669.
      View in: PubMed, PubMed Central
    156. Zhao B, Li L, Guan K. Hippo signaling at a glance. J Cell Sci. 2010 Dec 01; 123(Pt 23):4001-6. PMID: 21084559; PMCID: PMC2987436.
      View in: PubMed, PubMed Central
    157. Zhao S, Guan K. IDH1 mutant structures reveal a mechanism of dominant inhibition. Cell Res. 2010 Dec; 20(12):1279-81. PMID: 21079649.
      View in: PubMed
    158. Guan K, Xiong Y. Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci. 2011 Feb; 36(2):108-16. PMID: 20934340; PMCID: PMC3038179.
      View in: PubMed, PubMed Central
    159. Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, Zhao S, Xiong Y, Lei QY, Guan K. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem. 2010 Nov 26; 285(48):37159-69. PMID: 20858893; PMCID: PMC2988322.
      View in: PubMed, PubMed Central
    160. Guan K, Yu W, Lin Y, Xiong Y, Zhao S. Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc. 2010 Sep; 5(9):1583-95. PMID: 21085124; PMCID: PMC4889332.
      View in: PubMed, PubMed Central
    161. Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan K, Brown JH, Chen J, Sonenberg N, Condorelli G. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16. PMID: 20644257; PMCID: PMC2912201.
      View in: PubMed, PubMed Central
    162. Wang C, Yoo Y, Fan H, Kim E, Guan K, Guan JL. Regulation of Integrin ß 1 recycling to lipid rafts by Rab1a to promote cell migration. J Biol Chem. 2010 Sep 17; 285(38):29398-405. PMID: 20639577; PMCID: PMC2937972.
      View in: PubMed, PubMed Central
    163. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan K. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010 Jun 01; 24(11):1106-18. PMID: 20516196; PMCID: PMC2878649.
      View in: PubMed, PubMed Central
    164. Li L, Kim E, Yuan H, Inoki K, Goraksha-Hicks P, Schiesher RL, Neufeld TP, Guan K. Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem. 2010 Jun 25; 285(26):19705-9. PMID: 20457610; PMCID: PMC2888380.
      View in: PubMed, PubMed Central
    165. Zhao B, Li L, Lei Q, Guan K. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev. 2010 May; 24(9):862-74. PMID: 20439427; PMCID: PMC2861185.
      View in: PubMed, PubMed Central
    166. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan K. Regulation of cellular metabolism by protein lysine acetylation. Science. 2010 Feb 19; 327(5968):1000-4. PMID: 20167786; PMCID: PMC3232675.
      View in: PubMed, PubMed Central
    167. Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning ZB, Zeng R, Xiong Y, Guan K, Zhao S, Zhao GP. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science. 2010 Feb 19; 327(5968):1004-7. PMID: 20167787; PMCID: PMC4183141.
      View in: PubMed, PubMed Central
    168. Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan K, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4153-8. PMID: 20160076; PMCID: PMC2840158.
      View in: PubMed, PubMed Central
    169. Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan K, Xu Y. Structural insights into the YAP and TEAD complex. Genes Dev. 2010 Feb 01; 24(3):235-40. PMID: 20123905; PMCID: PMC2811825.
      View in: PubMed, PubMed Central
    170. Zhao B, Li L, Tumaneng K, Wang CY, Guan K. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev. 2010 Jan 01; 24(1):72-85. PMID: 20048001; PMCID: PMC2802193.
      View in: PubMed, PubMed Central
    171. Zhao B, Lei Q, Guan K. Mst out and HCC in. Cancer Cell. 2009 Nov 06; 16(5):363-4. PMID: 19878866.
      View in: PubMed
    172. Li L, Guan K. Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF. Mol Cell. 2009 Sep 11; 35(5):543-5. PMID: 19748348.
      View in: PubMed
    173. Mori H, Inoki K, Opland D, Münzberg H, Villanueva EC, Faouzi M, Ikenoue T, Kwiatkowski DJ, Macdougald OA, Myers MG, Guan K. Critical roles for the TSC-mTOR pathway in ß-cell function. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1013-22. PMID: 19690069.
      View in: PubMed
    174. Chang J, Wang Z, Tang E, Fan Z, McCauley L, Franceschi R, Guan K, Krebsbach PH, Wang CY. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med. 2009 Jun; 15(6):682-9. PMID: 19448637; PMCID: PMC2768554.
      View in: PubMed, PubMed Central
    175. Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan K. Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8923-8. PMID: 19458266; PMCID: PMC2690031.
      View in: PubMed, PubMed Central
    176. Mori H, Inoki K, Masutani K, Wakabayashi Y, Komai K, Nakagawa R, Guan K, Yoshimura A. The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. Biochem Biophys Res Commun. 2009 Jul 10; 384(4):471-5. PMID: 19422788.
      View in: PubMed
    177. Inoki K, Guan K. Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet. 2009 Apr 15; 18(R1):R94-100. PMID: 19297407; PMCID: PMC2657945.
      View in: PubMed, PubMed Central
    178. Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan K, Xiong Y. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009 Apr 10; 324(5924):261-5. PMID: 19359588; PMCID: PMC3251015.
      View in: PubMed, PubMed Central
    179. Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG, Guan K. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab. 2009 Apr; 9(4):362-74. PMID: 19356717; PMCID: PMC2790375.
      View in: PubMed, PubMed Central
    180. Kim E, Guan K. RAG GTPases in nutrient-mediated TOR signaling pathway. Cell Cycle. 2009 Apr 01; 8(7):1014-8. PMID: 19270521.
      View in: PubMed
    181. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan K. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009 May 15; 284(20):13355-62. PMID: 19324877; PMCID: PMC2679435.
      View in: PubMed, PubMed Central
    182. Yu W, Lin Y, Yao J, Huang W, Lei Q, Xiong Y, Zhao S, Guan K. Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem. 2009 May 15; 284(20):13669-75. PMID: 19318352; PMCID: PMC2679468.
      View in: PubMed, PubMed Central
    183. Zhao B, Lei QY, Guan K. Harness the power: new insights into the inhibition of YAP/Yorkie. Dev Cell. 2009 Mar; 16(3):321-2. PMID: 19289076.
      View in: PubMed
    184. Liu G, Li W, Wang L, Kar A, Guan K, Rao Y, Wu JY. DSCAM functions as a netrin receptor in commissural axon pathfinding. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2951-6. PMID: 19196994; PMCID: PMC2650370.
      View in: PubMed, PubMed Central
    185. Zhao B, Kim J, Ye X, Lai ZC, Guan K. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res. 2009 Feb 01; 69(3):1089-98. PMID: 19141641.
      View in: PubMed
    186. Zhao B, Lei QY, Guan K. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol. 2008 Dec; 20(6):638-46. PMID: 18955139; PMCID: PMC3296452.
      View in: PubMed, PubMed Central
    187. Chen C, Liu Y, Liu R, Ikenoue T, Guan K, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 2008 Sep 29; 205(10):2397-408. PMID: 18809716; PMCID: PMC2556783.
      View in: PubMed, PubMed Central
    188. Ikenoue T, Inoki K, Zhao B, Guan K. PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 2008 Sep 01; 68(17):6908-12. PMID: 18757404.
      View in: PubMed
    189. Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan K, Wan Y. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem. 2008 Oct 24; 283(43):28897-908. PMID: 18715874; PMCID: PMC2570892.
      View in: PubMed, PubMed Central
    190. Buller CL, Loberg RD, Fan MH, Zhu Q, Park JL, Vesely E, Inoki K, Guan K, Brosius FC. A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C836-43. PMID: 18650261; PMCID: PMC2544442.
      View in: PubMed, PubMed Central
    191. Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan K. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol. 2008 Aug; 10(8):935-45. PMID: 18604198; PMCID: PMC2711503.
      View in: PubMed, PubMed Central
    192. Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang CY, Chinnaiyan AM, Lai ZC, Guan K. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008 Jul 15; 22(14):1962-71. PMID: 18579750; PMCID: PMC2492741.
      View in: PubMed, PubMed Central
    193. Ikenoue T, Inoki K, Yang Q, Zhou X, Guan K. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23; 27(14):1919-31. PMID: 18566587; PMCID: PMC2486275.
      View in: PubMed, PubMed Central
    194. Zhao S, Guan K. Substrate selectivity APPLies to Akt. Cell. 2008 May 02; 133(3):399-400. PMID: 18455980.
      View in: PubMed
    195. Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan K. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol. 2008 Apr; 28(7):2426-36. PMID: 18227151; PMCID: PMC2268418.
      View in: PubMed, PubMed Central
    196. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan K. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007 Nov 01; 21(21):2747-61. PMID: 17974916; PMCID: PMC2045129.
      View in: PubMed, PubMed Central
    197. Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan K. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 2007 Nov 28; 26(23):4812-23. PMID: 17962806; PMCID: PMC2099465.
      View in: PubMed, PubMed Central
    198. Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, Guan K. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem. 2007 Dec 07; 282(49):35803-13. PMID: 17928295.
      View in: PubMed
    199. Yang Q, Guan K. Expanding mTOR signaling. Cell Res. 2007 Aug; 17(8):666-81. PMID: 17680028.
      View in: PubMed
    200. Liu G, Li W, Gao X, Li X, Jürgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan K, Rao Y. p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci. 2007 Jan 24; 27(4):957-68. PMID: 17251438; PMCID: PMC2014516.
      View in: PubMed, PubMed Central
    201. Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan K, Dong LQ, Liu F. Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem. 2007 Mar 16; 282(11):7991-6. PMID: 17244624.
      View in: PubMed
    202. Lee CH, Inoki K, Guan K. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol. 2007; 47:443-67. PMID: 16968213.
      View in: PubMed
    203. Yang Q, Inoki K, Ikenoue T, Guan K. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15; 20(20):2820-32. PMID: 17043309; PMCID: PMC1619946.
      View in: PubMed, PubMed Central
    204. Wan M, Wu X, Guan K, Han M, Zhuang Y, Xu T. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett. 2006 Oct 16; 580(24):5621-7. PMID: 16996505.
      View in: PubMed
    205. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan K. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006 Sep 08; 126(5):955-68. PMID: 16959574.
      View in: PubMed
    206. Yang Q, Inoki K, Kim E, Guan K. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6811-6. PMID: 16627617; PMCID: PMC1458976.
      View in: PubMed, PubMed Central
    207. Inoki K, Guan K. Complexity of the TOR signaling network. Trends Cell Biol. 2006 Apr; 16(4):206-12. PMID: 16516475.
      View in: PubMed
    208. Aurandt J, Li W, Guan K. Semaphorin 4D activates the MAPK pathway downstream of plexin-B1. Biochem J. 2006 Mar 01; 394(Pt 2):459-64. PMID: 16187944; PMCID: PMC1408676.
      View in: PubMed, PubMed Central
    209. Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan K. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem. 2006 Mar 31; 281(13):8313-6. PMID: 16464865.
      View in: PubMed
    210. Li Y, Inoki K, Vikis H, Guan K. Measurements of TSC2 GAP activity toward Rheb. Methods Enzymol. 2006; 407:46-54. PMID: 16757313.
      View in: PubMed
    211. Li W, Aurandt J, Jürgensen C, Jürgense C, Rao Y, Guan K. FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. J Cell Sci. 2006 Jan 01; 119(Pt 1):47-55. PMID: 16371650; PMCID: PMC2248276.
      View in: PubMed, PubMed Central
    212. Kruger RP, Aurandt J, Guan K. Semaphorins command cells to move. Nat Rev Mol Cell Biol. 2005 Oct; 6(10):789-800. PMID: 16314868.
      View in: PubMed
    213. Lee J, Li W, Guan K. SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans. Mol Cell Biol. 2005 Aug; 25(15):6485-95. PMID: 16024786; PMCID: PMC1190325.
      View in: PubMed, PubMed Central
    214. Gan B, Melkoumian ZK, Wu X, Guan K, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol. 2005 Aug 01; 170(3):379-89. PMID: 16043512; PMCID: PMC2171462.
      View in: PubMed, PubMed Central
    215. Inoki K, Ouyang H, Li Y, Guan K. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev. 2005 Mar; 69(1):79-100. PMID: 15755954; PMCID: PMC1082789.
      View in: PubMed, PubMed Central
    216. Yu Y, Li S, Xu X, Li Y, Guan K, Arnold E, Ding J. Structural basis for the unique biological function of small GTPase RHEB. J Biol Chem. 2005 Apr 29; 280(17):17093-100. PMID: 15728574.
      View in: PubMed
    217. Corradetti MN, Inoki K, Guan K. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18; 280(11):9769-72. PMID: 15632201.
      View in: PubMed
    218. Inoki K, Corradetti MN, Guan K. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005 Jan; 37(1):19-24. PMID: 15624019.
      View in: PubMed
    219. Kruger RP, Lee J, Li W, Guan K. Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. J Neurosci. 2004 Dec 01; 24(48):10826-34. PMID: 15574733.
      View in: PubMed
    220. Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan K. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci. 2004 Nov; 7(11):1213-21. PMID: 15494734; PMCID: PMC2373267.
      View in: PubMed, PubMed Central
    221. Li Y, Inoki K, Guan K. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol. 2004 Sep; 24(18):7965-75. PMID: 15340059; PMCID: PMC515062.
      View in: PubMed, PubMed Central
    222. Basile JR, Barac A, Zhu T, Guan K, Gutkind JS. Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res. 2004 Aug 01; 64(15):5212-24. PMID: 15289326.
      View in: PubMed
    223. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan K. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2004 Jul 01; 18(13):1533-8. PMID: 15231735; PMCID: PMC443516.
      View in: PubMed, PubMed Central
    224. Li W, Zhu T, Guan K. Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. J Biol Chem. 2004 Sep 03; 279(36):37398-406. PMID: 15210703.
      View in: PubMed
    225. Li W, Guan K. The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. J Biol Chem. 2004 Jul 30; 279(31):32824-31. PMID: 15169762.
      View in: PubMed
    226. Wang M, Devereux TR, Vikis HG, McCulloch SD, Holliday W, Anna C, Wang Y, Bebenek K, Kunkel TA, Guan K, You M. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Res. 2004 Mar 15; 64(6):1924-31. PMID: 15026325.
      View in: PubMed
    227. Ruan Q, Wang Q, Xie S, Fang Y, Darzynkiewicz Z, Guan K, Jhanwar-Uniyal M, Dai W. Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle. Exp Cell Res. 2004 Mar 10; 294(1):51-9. PMID: 14980500.
      View in: PubMed
    228. Yang F, Yamashita J, Tang E, Wang HL, Guan K, Wang CY. The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop. J Immunol. 2004 Feb 15; 172(4):2446-52. PMID: 14764716.
      View in: PubMed
    229. Li Y, Corradetti MN, Inoki K, Guan K. TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem Sci. 2004 Jan; 29(1):32-8. PMID: 14729330.
      View in: PubMed
    230. Yoder JH, Chong H, Guan K, Han M. Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J. 2004 Jan 14; 23(1):111-9. PMID: 14685271; PMCID: PMC1271663.
      View in: PubMed, PubMed Central
    231. Guan K, Rao Y. Signalling mechanisms mediating neuronal responses to guidance cues. Nat Rev Neurosci. 2003 Dec; 4(12):941-56. PMID: 14682358.
      View in: PubMed
    232. Zhou Q, Rammohan K, Lin S, Robinson N, Li O, Liu X, Bai XF, Yin L, Scarberry B, Du P, You M, Guan K, Zheng P, Liu Y. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15041-6. PMID: 14657362; PMCID: PMC299898.
      View in: PubMed, PubMed Central
    233. Inoki K, Zhu T, Guan K. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003 Nov 26; 115(5):577-90. PMID: 14651849.
      View in: PubMed
    234. Lanigan TM, Liu A, Huang YZ, Mei L, Margolis B, Guan K. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. FASEB J. 2003 Nov; 17(14):2048-60. PMID: 14597674.
      View in: PubMed
    235. Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan K, You M. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12642-7. PMID: 14583591; PMCID: PMC240671.
      View in: PubMed, PubMed Central
    236. Tang ED, Inohara N, Wang CY, Nuñez G, Guan K. Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. J Biol Chem. 2003 Oct 03; 278(40):38566-70. PMID: 12890679.
      View in: PubMed
    237. Inoki K, Li Y, Xu T, Guan K. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003 Aug 01; 17(15):1829-34. PMID: 12869586; PMCID: PMC196227.
      View in: PubMed, PubMed Central
    238. Tang ED, Wang CY, Xiong Y, Guan K. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem. 2003 Sep 26; 278(39):37297-305. PMID: 12867425.
      View in: PubMed
    239. Chong H, Guan K. Regulation of Raf through phosphorylation and N terminus-C terminus interaction. J Biol Chem. 2003 Sep 19; 278(38):36269-76. PMID: 12865432.
      View in: PubMed
    240. Yang F, Tang E, Guan K, Wang CY. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol. 2003 Jun 01; 170(11):5630-5. PMID: 12759443.
      View in: PubMed
    241. Li Y, Inoki K, Vacratsis P, Guan K. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2003 Apr 18; 278(16):13663-71. PMID: 12582162.
      View in: PubMed
    242. Li Y, Inoki K, Yeung R, Guan K. Regulation of TSC2 by 14-3-3 binding. J Biol Chem. 2002 Nov 22; 277(47):44593-6. PMID: 12364343.
      View in: PubMed
    243. Inoki K, Li Y, Zhu T, Wu J, Guan K. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002 Sep; 4(9):648-57. PMID: 12172553.
      View in: PubMed
    244. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan K. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12085-90. PMID: 12196628; PMCID: PMC129402.
      View in: PubMed, PubMed Central
    245. You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan K, MacDougald OA, Brown AM, Evan G, Kitajewski J, Wang CY. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol. 2002 Apr 29; 157(3):429-40. PMID: 11980918; PMCID: PMC2173296.
      View in: PubMed, PubMed Central
    246. Vikis HG, Stewart S, Guan K. SmgGDS displays differential binding and exchange activity towards different Ras isoforms. Oncogene. 2002 Apr 04; 21(15):2425-32. PMID: 11948427.
      View in: PubMed
    247. Vikis HG, Li W, Guan K. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes Dev. 2002 Apr 01; 16(7):836-45. PMID: 11937491; PMCID: PMC186329.
      View in: PubMed, PubMed Central
    248. Vikis H, Guan K. Regulation of the Ras-MAPK pathway at the level of Ras and Raf. Genet Eng (N Y). 2002; 24:49-66. PMID: 12416300.
      View in: PubMed
    249. Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan K, Zhang C, Chen H, He F. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. FASEB J. 2002 Jan; 16(1):90-2. PMID: 11709497.
      View in: PubMed
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