Itay Budin

Title(s)Assistant Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Cornell University, Ithaca, NYBS06/2007Bioengineering
    Harvard University, Cambridge, MAPhD11/2012Biochemistry
    Collapse Awards and Honors
    American Society for Biochemistry and Molecular Biology2023Walter Shaw Award
    Department of Energy2022  - 2027Early Career Research Award
    National Science Foundation2021  - 2026CAREER Award
    American Society for Biochemistry and Molecular Biology2017Herb Tabor Young Investigator Award
    Miller Institute2012  - 2015Miller Junior Fellowship
    Fred Hutchinson Cancer Center2012Harold M. Weintraub Award
    Harvard University2009Matt Meselson Prize

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Collaborative Research: IntBIO: Rules for cell membranes in the extremes of the deep sea
    NSF MCB2316458Jul 1, 2023 - Jun 30, 2028
    Role: Principal Investigator
    Biophysical drivers of decompression tolerance in cell membranes
    ONR N000142312543Jun 1, 2023 - May 31, 2026
    Role: Principal Investigator
    Synthetic membrane biology in microbial cell factories
    DOE DESC0022954Jul 1, 2022 - Jun 30, 2027
    Role: Principal Investigator
    Lipidic drivers of organelle function and dysregulation
    NIH R35GM142960Aug 1, 2021 - Jul 31, 2026
    Role: Principal Investigator
    CAREER: Structure, function, and evolution of lipid domains in living cells
    NSF MCB2046303Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Temperature adaptive behavior mediated by inter-kingdom lipid exchange
    NSF IOS2040022May 1, 2021 - Apr 30, 2024
    Role: Principal Investigator
    The evolution of cell membrane structure and oxygen requirements during eukaryogenesis
    Moore Foundation GBMF9734Sep 1, 2020 - Aug 31, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rapid Formation of Non-canonical Phospholipid Membranes by Chemoselective Amide-Forming Ligations with Hydroxylamines. Angew Chem Int Ed Engl. 2024 Jan 02; 63(1):e202311635. Chen J, Brea RJ, Fracassi A, Cho CJ, Wong AM, Salvador-Castell M, Sinha SK, Budin I, Devaraj NK. PMID: 37919232.
      View in: PubMed   Mentions:    Fields:    
    2. Intracellular sphingolipid sorting drives membrane phase separation in the yeast vacuole. J Biol Chem. 2024 Jan; 300(1):105496. Kim H, Budin I. PMID: 38013088; PMCID: PMC10776997.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome. EMBO J. 2023 Dec 11; 42(24):e114054. Venkatraman K, Lee CT, Garcia GC, Mahapatra A, Milshteyn D, Perkins G, Kim KY, Pasolli HA, Phan S, Lippincott-Schwartz J, Ellisman MH, Rangamani P, Budin I. PMID: 37933600; PMCID: PMC10711667.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome. bioRxiv. 2023 Sep 02. Venkatraman K, Lee CT, Garcia GC, Mahapatra A, Milshteyn D, Perkins G, Kim KY, Pasolli HA, Phan S, Lippincott-Schwartz J, Ellisman MH, Rangamani P, Budin I. PMID: 36993370; PMCID: PMC10054968.
      View in: PubMed   Mentions:
    5. Depth- and temperature-specific fatty acid adaptations in ctenophores from extreme habitats. J Exp Biol. 2021 11 01; 224(21). Winnikoff JR, Haddock SHD, Budin I. PMID: 34676421; PMCID: PMC8627573.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    6. Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology. Curr Opin Chem Biol. 2021 12; 65:66-73. Moore WM, Milshteyn D, Tsai YT, Budin I. PMID: 34218059.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. ATP synthase: Evolution, energetics, and membrane interactions. J Gen Physiol. 2020 11 02; 152(11). Nirody JA, Budin I, Rangamani P. PMID: 32966553; PMCID: PMC7594442.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    8. Bringing rafts to life: Lessons learned from lipid organization across diverse biological membranes. Chem Phys Lipids. 2020 11; 233:104984. Tsai YT, Moore W, Kim H, Budin I. PMID: 33203526.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    9. Aging membranes: Unexplored functions for lipids in the lifespan of the central nervous system. Exp Gerontol. 2020 03; 131:110817. Skowronska-Krawczyk D, Budin I. PMID: 31862420; PMCID: PMC7877915.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    10. Distinct functional roles for hopanoid composition in the chemical tolerance of Zymomonas mobilis. Mol Microbiol. 2019 11; 112(5):1564-1575. Brenac L, Baidoo EEK, Keasling JD, Budin I. PMID: 31468587.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    11. The Transcriptome and Flux Profiling of Crabtree-Negative Hydroxy Acid-Producing Strains of Saccharomyces cerevisiae Reveals Changes in the Central Carbon Metabolism. Biotechnol J. 2019 Sep; 14(9):e1900013. Jessop-Fabre MM, Dahlin J, Biron MB, Stovicek V, Ebert BE, Blank LM, Budin I, Keasling JD, Borodina I. PMID: 30969019.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Lipid determinants of endocytosis and exocytosis in budding yeast. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 07; 1864(7):1005-1016. Degreif D, Cucu B, Budin I, Thiel G, Bertl A. PMID: 30917917.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    13. Synthetic Biology for Fundamental Biochemical Discovery. Biochemistry. 2019 03 19; 58(11):1464-1469. Budin I, Keasling JD. PMID: 30350947.
      View in: PubMed   Mentions: 4     Fields:    
    14. Viscous control of cellular respiration by membrane lipid composition. Science. 2018 12 07; 362(6419):1186-1189. Budin I, de Rond T, Chen Y, Chan LJG, Petzold CJ, Keasling JD. PMID: 30361388.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    15. Lipid engineering reveals regulatory roles for membrane fluidity in yeast flocculation and oxygen-limited growth. Metab Eng. 2017 05; 41:46-56. Degreif D, de Rond T, Bertl A, Keasling JD, Budin I. PMID: 28323063.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    16. Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions. Biophys J. 2014 Oct 07; 107(7):1582-90. Budin I, Prwyes N, Zhang N, Szostak JW. PMID: 25296310; PMCID: PMC4190651.
      View in: PubMed   Mentions: 31     Fields:    
    17. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. Methods Enzymol. 2013; 533:267-74. Zhu TF, Budin I, Szostak JW. PMID: 24182932; PMCID: PMC4310237.
      View in: PubMed   Mentions: 1     Fields:    
    18. Preparation of fatty acid micelles. Methods Enzymol. 2013; 533:283-8. Zhu TF, Budin I, Szostak JW. PMID: 24182934; PMCID: PMC4310231.
      View in: PubMed   Mentions: 7     Fields:    
    19. Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. Methods Enzymol. 2013; 533:275-82. Zhu TF, Budin I, Szostak JW. PMID: 24182933; PMCID: PMC4310236.
      View in: PubMed   Mentions: 6     Fields:    
    20. Concentration-driven growth of model protocell membranes. J Am Chem Soc. 2012 Dec 26; 134(51):20812-9. Budin I, Debnath A, Szostak JW. PMID: 23198690; PMCID: PMC3530389.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    21. Membrane assembly driven by a biomimetic coupling reaction. J Am Chem Soc. 2012 Jan 18; 134(2):751-3. Budin I, Devaraj NK. PMID: 22239722; PMCID: PMC3262119.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    22. Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5249-54. Budin I, Szostak JW. PMID: 21402937; PMCID: PMC3069173.
      View in: PubMed   Mentions: 89     Fields:    Translation:Cells
    23. Expanding roles for diverse physical phenomena during the origin of life. Annu Rev Biophys. 2010; 39:245-63. Budin I, Szostak JW. PMID: 20192779; PMCID: PMC4992673.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    24. Formation of protocell-like vesicles in a thermal diffusion column. J Am Chem Soc. 2009 Jul 22; 131(28):9628-9. Budin I, Bruckner RJ, Szostak JW. PMID: 19601679; PMCID: PMC2710859.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
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