Itay Budin

Title(s)	Assistant Professor, Chemistry and Biochemistry
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

Cornell University, Ithaca, NY	BS	06/2007	Bioengineering
Harvard University, Cambridge, MA	PhD	11/2012	Biochemistry

Awards and Honors

Revelle College	2024		Outstanding Teacher Award
American Society for Biochemistry and Molecular Biology	2023		Walter Shaw Award
Department of Energy	2022 -	2027	Early Career Research Award
National Science Foundation	2021 -	2026	CAREER Award
American Society for Biochemistry and Molecular Biology	2017		Herb Tabor Young Investigator Award
Miller Institute	2012 -	2015	Miller Junior Fellowship
Fred Hutchinson Cancer Center	2012		Harold M. Weintraub Award
Harvard University	2009		Matt Meselson Prize

Overview

Websites

Lab website

In The News

	Comb jellies withstand deep sea water pressure by reshaping molecules (07/10/2024)
	Deep-sea comb jellies’ cells are primed to withstand pressure (07/10/2024)
	How Deep-Sea Comb Jellies Hold Their Shape Under Crushing Pressure (07/03/2024)
	How jellyfish survive pressures that would crush you into oblivion (06/27/2024)
	How Delicate Comb Jellies Withstand Crushing Depths—But Melt Away on Land (06/27/2024)
	Deep-sea creatures survive crushing pressures with just the right fats (06/27/2024)
	Under Pressure: How Comb Jellies Have Adapted to Life at the Bottom of the Ocean (06/27/2024)
	Performance under pressure (06/27/2024)
	Ambitious Project to Understand Cellular Evolution Underway (10/06/2020)

Research

Research Activities and Funding

Collaborative Research: IntBIO: Rules for cell membranes in the extremes of the deep sea
NSF MCB2316458Jul 1, 2023 - Jun 30, 2028
Role: Principal Investigator

Biophysical drivers of decompression tolerance in cell membranes
ONR N000142312543Jun 1, 2023 - May 31, 2026
Role: Principal Investigator

Synthetic membrane biology in microbial cell factories
DOE DESC0022954Jul 1, 2022 - Jun 30, 2027
Role: Principal Investigator

Lipidic drivers of organelle function and dysregulation
NIH R35GM142960Aug 1, 2021 - Jul 31, 2026
Role: Principal Investigator

CAREER: Structure, function, and evolution of lipid domains in living cells
NSF MCB2046303Jul 1, 2021 - Jun 30, 2026
Role: Principal Investigator

Temperature adaptive behavior mediated by inter-kingdom lipid exchange
NSF IOS2040022May 1, 2021 - Apr 30, 2024
Role: Principal Investigator

The evolution of cell membrane structure and oxygen requirements during eukaryogenesis
Moore Foundation GBMF9734Sep 1, 2020 - Aug 31, 2024
Role: Principal Investigator

Featured Content

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Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Setting the curve: the biophysical properties of lipids in mitochondrial form and function. J Lipid Res. 2024 Sep 18; 65(10):100643. Venkatraman K, Lee CT, Budin I. PMID: 39303982.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Organelle-Targeted Laurdans Measure Heterogeneity in Subcellular Membranes and Their Responses to Saturated Lipid Stress. ACS Chem Biol. 2024 Aug 16; 19(8):1773-1785. Wong AM, Budin I. PMID: 39069657.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Cells
Cardiolipin remodeling maintains the inner mitochondrial membrane in cells with saturated lipidomes. J Lipid Res. 2024 Aug; 65(8):100601. Venkatraman K, Budin I. PMID: 39038656; PMCID: PMC11381790.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Homeocurvature adaptation of phospholipids to pressure in deep-sea invertebrates. Science. 2024 Jun 28; 384(6703):1482-1488. Winnikoff JR, Milshteyn D, Vargas-Urbano SJ, Pedraza-Joya MA, Armando AM, Quehenberger O, Sodt A, Gillilan RE, Dennis EA, Lyman E, Haddock SHD, Budin I. PMID: 38935710.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Animals Cells
Subcellular imaging of lipids and sugars using genetically encoded proximity sensors. bioRxiv. 2024 May 03. Moore WM, Brea RJ, Knittel C, Wrightsman E, Hui B, Lou J, Ancajas CF, Best MD, Devaraj NK, Budin I. PMID: 38746395; PMCID: PMC11092643.

View in: PubMed Mentions:
Organelle-targeted Laurdans measure heterogeneity in subcellular membranes and their responses to saturated lipid stress. bioRxiv. 2024 Apr 20. Wong AM, Budin I. PMID: 38659784; PMCID: PMC11042318.

View in: PubMed Mentions:
Using the yeast vacuole as a system to test the lipidic drivers of membrane heterogeneity in living cells. Methods Enzymol. 2024; 700:77-104. Kim H, Juarez-Contreras I, Budin I. PMID: 38971613.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Animals Cells
Rapid Formation of Non-canonical Phospholipid Membranes by Chemoselective Amide-Forming Ligations with Hydroxylamines. Angew Chem Int Ed Engl. 2024 01 02; 63(1):e202311635. Chen J, Brea RJ, Fracassi A, Cho CJ, Wong AM, Salvador-Castell M, Sinha SK, Budin I, Devaraj NK. PMID: 37919232; PMCID: PMC11179435.

View in: PubMed Mentions: Fields:
Che Chemistry
Intracellular sphingolipid sorting drives membrane phase separation in the yeast vacuole. J Biol Chem. 2024 Jan; 300(1):105496. Kim H, Budin I. PMID: 38013088; PMCID: PMC10776997.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Animals Cells
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome. EMBO J. 2023 Dec 11; 42(24):e114054. Venkatraman K, Lee CT, Garcia GC, Mahapatra A, Milshteyn D, Perkins G, Kim KY, Pasolli HA, Phan S, Lippincott-Schwartz J, Ellisman MH, Rangamani P, Budin I. PMID: 37933600; PMCID: PMC10711667.

View in: PubMed Mentions: 6 Fields:
Bio Biotechnology Mol Molecular Biology
Translation:Animals Cells
Depth- and temperature-specific fatty acid adaptations in ctenophores from extreme habitats. J Exp Biol. 2021 11 01; 224(21). Winnikoff JR, Haddock SHD, Budin I. PMID: 34676421; PMCID: PMC8627573.

View in: PubMed Mentions: 9 Fields:
Bio Biology
Translation:Animals
Engineering the bilayer: Emerging genetic tool kits for mechanistic lipid biology. Curr Opin Chem Biol. 2021 12; 65:66-73. Moore WM, Milshteyn D, Tsai YT, Budin I. PMID: 34218059.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Cells
ATP synthase: Evolution, energetics, and membrane interactions. J Gen Physiol. 2020 11 02; 152(11). Nirody JA, Budin I, Rangamani P. PMID: 32966553; PMCID: PMC7594442.

View in: PubMed Mentions: 25 Fields:
Phy Physiology
Translation:Humans Animals Cells
Bringing rafts to life: Lessons learned from lipid organization across diverse biological membranes. Chem Phys Lipids. 2020 11; 233:104984. Tsai YT, Moore W, Kim H, Budin I. PMID: 33203526.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry
Translation:Cells
Aging membranes: Unexplored functions for lipids in the lifespan of the central nervous system. Exp Gerontol. 2020 03; 131:110817. Skowronska-Krawczyk D, Budin I. PMID: 31862420; PMCID: PMC7877915.

View in: PubMed Mentions: 18 Fields:
Ger Geriatrics
Translation:Humans
Distinct functional roles for hopanoid composition in the chemical tolerance of Zymomonas mobilis. Mol Microbiol. 2019 11; 112(5):1564-1575. Brenac L, Baidoo EEK, Keasling JD, Budin I. PMID: 31468587.

View in: PubMed Mentions: 17 Fields:
Mic Microbiology Mol Molecular Biology
Translation:Cells
The Transcriptome and Flux Profiling of Crabtree-Negative Hydroxy Acid-Producing Strains of Saccharomyces cerevisiae Reveals Changes in the Central Carbon Metabolism. Biotechnol J. 2019 Sep; 14(9):e1900013. Jessop-Fabre MM, Dahlin J, Biron MB, Stovicek V, Ebert BE, Blank LM, Budin I, Keasling JD, Borodina I. PMID: 30969019.

View in: PubMed Mentions: 1 Fields:
Bio Biotechnology
Translation:Animals Cells
Lipid determinants of endocytosis and exocytosis in budding yeast. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 07; 1864(7):1005-1016. Degreif D, Cucu B, Budin I, Thiel G, Bertl A. PMID: 30917917.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry Bio Biophysics Cel Cell Biology
Translation:Animals Cells
Synthetic Biology for Fundamental Biochemical Discovery. Biochemistry. 2019 03 19; 58(11):1464-1469. Budin I, Keasling JD. PMID: 30350947.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry
Viscous control of cellular respiration by membrane lipid composition. Science. 2018 12 07; 362(6419):1186-1189. Budin I, de Rond T, Chen Y, Chan LJG, Petzold CJ, Keasling JD. PMID: 30361388.

View in: PubMed Mentions: 70 Fields:
Sci Science
Translation:Cells
Lipid engineering reveals regulatory roles for membrane fluidity in yeast flocculation and oxygen-limited growth. Metab Eng. 2017 05; 41:46-56. Degreif D, de Rond T, Bertl A, Keasling JD, Budin I. PMID: 28323063.

View in: PubMed Mentions: 17 Fields:
Bio Biomedical Engineering Met Metabolism
Translation:Animals Cells
Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions. Biophys J. 2014 Oct 07; 107(7):1582-90. Budin I, Prwyes N, Zhang N, Szostak JW. PMID: 25296310; PMCID: PMC4190651.

View in: PubMed Mentions: 33 Fields:
Bio Biophysics
Preparation of fatty acid micelles. Methods Enzymol. 2013; 533:283-8. Zhu TF, Budin I, Szostak JW. PMID: 24182934; PMCID: PMC4310231.

View in: PubMed Mentions: 7 Fields:
Bio Biochemistry
Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. Methods Enzymol. 2013; 533:267-74. Zhu TF, Budin I, Szostak JW. PMID: 24182932; PMCID: PMC4310237.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. Methods Enzymol. 2013; 533:275-82. Zhu TF, Budin I, Szostak JW. PMID: 24182933; PMCID: PMC4310236.

View in: PubMed Mentions: 7 Fields:
Bio Biochemistry
Concentration-driven growth of model protocell membranes. J Am Chem Soc. 2012 Dec 26; 134(51):20812-9. Budin I, Debnath A, Szostak JW. PMID: 23198690; PMCID: PMC3530389.

View in: PubMed Mentions: 42 Fields:
Che Chemistry
Translation:Cells
Membrane assembly driven by a biomimetic coupling reaction. J Am Chem Soc. 2012 Jan 18; 134(2):751-3. Budin I, Devaraj NK. PMID: 22239722; PMCID: PMC3262119.

View in: PubMed Mentions: 31 Fields:
Che Chemistry
Translation:Cells
Physical effects underlying the transition from primitive to modern cell membranes. Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13):5249-54. Budin I, Szostak JW. PMID: 21402937; PMCID: PMC3069173.

View in: PubMed Mentions: 89 Fields:
Sci Science
Translation:Cells
Expanding roles for diverse physical phenomena during the origin of life. Annu Rev Biophys. 2010; 39:245-63. Budin I, Szostak JW. PMID: 20192779; PMCID: PMC4992673.

View in: PubMed Mentions: 39 Fields:
Bio Biophysics
Translation:Cells
Formation of protocell-like vesicles in a thermal diffusion column. J Am Chem Soc. 2009 Jul 22; 131(28):9628-9. Budin I, Bruckner RJ, Szostak JW. PMID: 19601679; PMCID: PMC2710859.

View in: PubMed Mentions: 45 Fields:
Che Chemistry
Translation:Cells