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    Ana Pajor

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0714
    CA La Jolla 92093
    Phone858-822-7806
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      Collapse Research 
      Collapse Research Activities and Funding
      Involvement of Na/Dicarboxylate Cotransporter in Aging
      NIH/NIA R03AG020810Apr 1, 2002 - Mar 31, 2004
      Role: Principal Investigator
      MECHANISM OF RENAL NA/DICARBOXYLATE TRANSPORT
      NIH/NIDDK K02DK002429Aug 10, 1996 - Jul 31, 2002
      Role: Principal Investigator
      Molecular Mechanism of Renal Na+ Dependent Cotransport
      NIH/NIDDK R01DK046269Apr 1, 1993 - Jun 30, 2012
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Colas C, Schlessinger A, Pajor A. Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1. Biochemistry. 2017 Aug 22; 56(33):4432-4441. PMID: 28731330.
        View in: PubMed
      2. Pajor A, de Oliveira CA, Song K, Huard K, Shanmugasundaram V, Erion DM. Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors. Mol Pharmacol. 2016 Dec; 90(6):755-765. PMID: 27683012.
        View in: PubMed
      3. Colas C, Pajor A, Schlessinger A. Structure-Based Identification of Inhibitors for the SLC13 Family of Na(+)/Dicarboxylate Cotransporters. Biochemistry. 2015 Aug 11; 54(31):4900-8. PMID: 26176240; PMCID: PMC4781755.
      4. Schlessinger A, Sun NN, Colas C, Pajor A. Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3. J Biol Chem. 2014 Jun 13; 289(24):16998-7008. PMID: 24808185; PMCID: PMC4059142.
      5. Hering-Smith KS, Mao W, Schiro FR, Coleman-Barnett J, Pajor A, Hamm LL. Localization of the calcium-regulated citrate transport process in proximal tubule cells. Urolithiasis. 2014 Jun; 42(3):209-19. PMID: 24652587; PMCID: PMC4106718.
      6. Pajor A. Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch. 2014 Jan; 466(1):119-30. PMID: 24114175.
        View in: PubMed
      7. Pajor A, Sun NN, Leung A. Functional characterization of SdcF from Bacillus licheniformis, a homolog of the SLC13 Na?/dicarboxylate transporters. J Membr Biol. 2013 Sep; 246(9):705-15. PMID: 23979173.
        View in: PubMed
      8. Pajor A, Sun NN. Nonsteroidal anti-inflammatory drugs and other anthranilic acids inhibit the Na(+)/dicarboxylate symporter from Staphylococcus aureus. Biochemistry. 2013 Apr 30; 52(17):2924-32. PMID: 23566164.
        View in: PubMed
      9. Hering-Smith KS, Schiro FR, Pajor A, Hamm LL. Calcium sensitivity of dicarboxylate transport in cultured proximal tubule cells. Am J Physiol Renal Physiol. 2011 Feb; 300(2):F425-32. PMID: 21123491; PMCID: PMC3043994.
      10. Pajor A, Sun NN, Joshi AD, Randolph KM. Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function. Biochim Biophys Acta. 2011 Jun; 1808(6):1454-61. PMID: 21073858; PMCID: PMC3046213.
      11. Pajor A, Sun NN. Role of isoleucine-554 in lithium binding by the Na+/dicarboxylate cotransporter NaDC1. Biochemistry. 2010 Oct 19; 49(41):8937-43. PMID: 20845974; PMCID: PMC2956517.
      12. Pajor A, Sun NN. Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F704-11. PMID: 20610529; PMCID: PMC2957249.
      13. Strickler MA, Hall JA, Gaiko O, Pajor A. Functional characterization of a Na(+)-coupled dicarboxylate transporter from Bacillus licheniformis. Biochim Biophys Acta. 2009 Dec; 1788(12):2489-96. PMID: 19840771; PMCID: PMC2787743.
      14. Joshi AD, Pajor A. Identification of conformationally sensitive amino acids in the Na(+)/dicarboxylate symporter (SdcS). Biochemistry. 2009 Apr 07; 48(13):3017-24. PMID: 19260674; PMCID: PMC2666955.
      15. Weerachayaphorn J, Pajor A. Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter. Biochemistry. 2008 Jan 22; 47(3):1087-93. PMID: 18161988; PMCID: PMC2570185.
      16. Weerachayaphorn J, Pajor A. Identification of transport pathways for citric acid cycle intermediates in the human colon carcinoma cell line, Caco-2. Biochim Biophys Acta. 2008 Apr; 1778(4):1051-9. PMID: 18194662; PMCID: PMC2323910.
      17. Pajor A, Randolph KM, Kerner SA, Smith CD. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar; 324(3):985-91. PMID: 18063724.
        View in: PubMed
      18. Pajor A, Randolph KM. Inhibition of the Na+/dicarboxylate cotransporter by anthranilic acid derivatives. Mol Pharmacol. 2007 Nov; 72(5):1330-6. PMID: 17715401.
        View in: PubMed
      19. Weerachayaphorn J, Pajor A. Sodium-dependent extracellular accessibility of Lys-84 in the sodium/dicarboxylate cotransporter. J Biol Chem. 2007 Jul 13; 282(28):20213-20. PMID: 17504760; PMCID: PMC2864014.
      20. Hall JA, Pajor A. Functional reconstitution of SdcS, a Na+-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2007 Feb; 189(3):880-5. PMID: 17114260; PMCID: PMC1797332.
      21. Oshiro N, Pajor A. Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter. Biochim Biophys Acta. 2006 Jun; 1758(6):781-8. PMID: 16787639; PMCID: PMC1622917.
      22. Joshi AD, Pajor A. Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1. Biochemistry. 2006 Apr 04; 45(13):4231-9. PMID: 16566597; PMCID: PMC2547120.
      23. Oshiro N, King SC, Pajor A. Transmembrane helices 3 and 4 are involved in substrate recognition by the Na+/dicarboxylate cotransporter, NaDC1. Biochemistry. 2006 Feb 21; 45(7):2302-10. PMID: 16475819.
        View in: PubMed
      24. Pajor A. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch. 2006 Feb; 451(5):597-605. PMID: 16211368; PMCID: PMC1866268.
      25. Hall JA, Pajor A. Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2005 Aug; 187(15):5189-94. PMID: 16030212; PMCID: PMC1196027.
      26. Oshiro N, Pajor A. Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1159-68. PMID: 15944208.
        View in: PubMed
      27. Pajor A, Randolph KM. Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2005 May 13; 280(19):18728-35. PMID: 15774465; PMCID: PMC1224748.
      28. Buddington RK, Pajor A, Buddington KK, Pierzynowski S. Absorption of alpha-ketoglutarate by the gastrointestinal tract of pigs. Comp Biochem Physiol A Mol Integr Physiol. 2004 Jun; 138(2):215-20. PMID: 15275656.
        View in: PubMed
      29. Aruga S, Pajor A, Nakamura K, Liu L, Moe OW, Preisig PA, Alpern RJ. OKP cells express the Na-dicarboxylate cotransporter NaDC-1. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C64-72. PMID: 14973148.
        View in: PubMed
      30. Li H, Pajor A. Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. Am J Physiol Cell Physiol. 2003 Nov; 285(5):C1188-96. PMID: 12867358.
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      31. Li H, Pajor A. Serines 260 and 288 are involved in sulfate transport by hNaSi-1. J Biol Chem. 2003 Sep 26; 278(39):37204-12. PMID: 12857732.
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      32. Yao X, Pajor A. Arginine-349 and aspartate-373 of the Na(+)/dicarboxylate cotransporter are conformationally sensitive residues. Biochemistry. 2002 Jan 22; 41(3):1083-90. PMID: 11790133.
        View in: PubMed
      33. Li H, Pajor A. Functional characterization of CitM, the Mg2+-citrate transporter. J Membr Biol. 2002 Jan 01; 185(1):9-16. PMID: 11891560.
        View in: PubMed
      34. Pajor A. Conformationally sensitive residues in transmembrane domain 9 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2001 Aug 10; 276(32):29961-8. PMID: 11399753.
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      35. Pajor A, Gangula R, Yao X. Cloning and functional characterization of a high-affinity Na(+)/dicarboxylate cotransporter from mouse brain. Am J Physiol Cell Physiol. 2001 May; 280(5):C1215-23. PMID: 11287335.
        View in: PubMed
      36. Zhang FF, Pajor A. Topology of the Na(+)/dicarboxylate cotransporter: the N-terminus and hydrophilic loop 4 are located intracellularly. Biochim Biophys Acta. 2001 Mar 09; 1511(1):80-9. PMID: 11248207.
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      37. Pajor A, Kahn ES, Gangula R. Role of cationic amino acids in the Na+/dicarboxylate co-transporter NaDC-1. Biochem J. 2000 Sep 15; 350 Pt 3:677-83. PMID: 10970779; PMCID: PMC1221297.
      38. Pajor A, Sun NN. Molecular cloning, chromosomal organization, and functional characterization of a sodium-dicarboxylate cotransporter from mouse kidney. Am J Physiol Renal Physiol. 2000 Sep; 279(3):F482-90. PMID: 10966927.
        View in: PubMed
      39. Aruga S, Wehrli S, Kaissling B, Moe OW, Preisig PA, Pajor A, Alpern RJ. Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney. Kidney Int. 2000 Jul; 58(1):206-15. PMID: 10886565.
        View in: PubMed
      40. Yao X, Pajor A. The transport properties of the human renal Na(+)- dicarboxylate cotransporter under voltage-clamp conditions. Am J Physiol Renal Physiol. 2000 Jul; 279(1):F54-64. PMID: 10894787.
        View in: PubMed
      41. Meinild AK, Loo DD, Pajor A, Zeuthen T, Wright EM. Water transport by the renal Na(+)-dicarboxylate cotransporter. Am J Physiol Renal Physiol. 2000 May; 278(5):F777-83. PMID: 10807589.
        View in: PubMed
      42. Pajor A. Molecular properties of sodium/dicarboxylate cotransporters. J Membr Biol. 2000 May 01; 175(1):1-8. PMID: 10811962.
        View in: PubMed
      43. Pajor A, Krajewski SJ, Sun N, Gangula R. Cysteine residues in the Na+/dicarboxylate co-transporter, NaDC-1. Biochem J. 1999 Nov 15; 344 Pt 1:205-9. PMID: 10548552; PMCID: PMC1220632.
      44. Pajor A, Sun N. Protein kinase C-mediated regulation of the renal Na(+)/dicarboxylate cotransporter, NaDC-1. Biochim Biophys Acta. 1999 Aug 20; 1420(1-2):223-30. PMID: 10446305.
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      45. Griffith DA, Pajor A. Acidic residues involved in cation and substrate interactions in the Na+/dicarboxylate cotransporter, NaDC-1. Biochemistry. 1999 Jun 08; 38(23):7524-31. PMID: 10360950.
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      46. Kahn ES, Pajor A. Determinants of substrate and cation affinities in the Na+/dicarboxylate cotransporter. Biochemistry. 1999 May 11; 38(19):6151-6. PMID: 10320342.
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      47. Pajor A. Citrate transport by the kidney and intestine. Semin Nephrol. 1999 Mar; 19(2):195-200. PMID: 10192253.
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      48. Kekuda R, Wang H, Huang W, Pajor A, Leibach FH, Devoe LD, Prasad PD, Ganapathy V. Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter. J Biol Chem. 1999 Feb 05; 274(6):3422-9. PMID: 9920886.
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      49. Pajor A. Sodium-coupled transporters for Krebs cycle intermediates. Annu Rev Physiol. 1999; 61:663-82. PMID: 10099705.
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      50. Pajor A. Sequence of a pyrimidine-selective Na+/nucleoside cotransporter from pig kidney, pkCNT1. Biochim Biophys Acta. 1998 Dec 09; 1415(1):266-9. PMID: 9858747.
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      51. Pajor A, Hirayama BA, Loo DD. Sodium and lithium interactions with the Na+/Dicarboxylate cotransporter. J Biol Chem. 1998 Jul 24; 273(30):18923-9. PMID: 9668069.
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      52. Pajor A, Sun N, Valmonte HG. Mutational analysis of histidine residues in the rabbit Na+/dicarboxylate co-transporter NaDC-1. Biochem J. 1998 Apr 01; 331 ( Pt 1):257-64. PMID: 9512488; PMCID: PMC1219347.
      53. Pajor A, Sun N, Bai L, Markovich D, Sule P. The substrate recognition domain in the Na+/dicarboxylate and Na+/sulfate cotransporters is located in the carboxy-terminal portion of the protein. Biochim Biophys Acta. 1998 Mar 06; 1370(1):98-106. PMID: 9518567.
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      54. Bai L, Pajor A. Expression cloning of NaDC-2, an intestinal Na(+)- or Li(+)-dependent dicarboxylate transporter. Am J Physiol. 1997 Aug; 273(2 Pt 1):G267-74. PMID: 9277403.
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      55. Pajor A, Sun N. Characterization of the rabbit renal Na(+)-dicarboxylate cotransporter using antifusion protein antibodies. Am J Physiol. 1996 Dec; 271(6 Pt 1):C1808-16. PMID: 8997180.
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      56. Pajor A, Sun N. Functional differences between rabbit and human Na(+)-dicarboxylate cotransporters, NaDC-1 and hNaDC-1. Am J Physiol. 1996 Nov; 271(5 Pt 2):F1093-9. PMID: 8946005.
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      57. Pajor A. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am J Physiol. 1996 Apr; 270(4 Pt 2):F642-8. PMID: 8967342.
        View in: PubMed
      58. Pajor A, Valmonte HG. Expression of the renal Na+/dicarboxylate cotransporter, NaDC-1, in COS-7 cells. Pflugers Arch. 1996 Feb; 431(4):645-51. PMID: 8596711.
        View in: PubMed
      59. Pajor A. Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter. J Biol Chem. 1995 Mar 17; 270(11):5779-85. PMID: 7890707.
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      60. Pajor A. Sequence of a putative transporter from rabbit kidney related to the Na+/glucose cotransporter gene family. Biochim Biophys Acta. 1994 Sep 14; 1194(2):349-51. PMID: 7918548.
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      61. Wells RG, Pajor A, Kanai Y, Turk E, Wright EM, Hediger MA. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol. 1992 Sep; 263(3 Pt 2):F459-65. PMID: 1415574.
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      62. Pajor A, Hirayama BA, Wright EM. Molecular evidence for two renal Na+/glucose cotransporters. Biochim Biophys Acta. 1992 Apr 29; 1106(1):216-20. PMID: 1581333.
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      63. Pajor A, Wright EM. Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family. J Biol Chem. 1992 Feb 25; 267(6):3557-60. PMID: 1740408.
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      64. Wright SH, Pajor A, Moon DA, Wunz TM. High-affinity phlorizin binding in Mytilus gill. Biochim Biophys Acta. 1992 Jan 31; 1103(2):212-8. PMID: 1543705.
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      65. Coady MJ, Pajor A, Toloza EM, Wright EM. Expression of mammalian renal transporters in Xenopus laevis oocytes. Arch Biochem Biophys. 1990 Nov 15; 283(1):130-4. PMID: 2241165.
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      66. Coady MJ, Pajor A, Wright EM. Sequence homologies among intestinal and renal Na+/glucose cotransporters. Am J Physiol. 1990 Oct; 259(4 Pt 1):C605-10. PMID: 2221040.
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      67. Wright SH, Pajor A. Mechanisms of integumental amino acid transport in marine bivalves. Am J Physiol. 1989 Sep; 257(3 Pt 2):R473-83. PMID: 2506769.
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      68. Hediger MA, Turk E, Pajor A, Wright EM. Molecular genetics of the human Na+/glucose cotransporter. Klin Wochenschr. 1989 Sep 01; 67(17):843-6. PMID: 2681963.
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      69. Pajor A, Wright SH. Uptake of lysine and proline via separate alpha-neutral amino acid transport pathways in Mytilus gill brush border membranes. J Membr Biol. 1989 Mar; 107(3):237-47. PMID: 2497258.
        View in: PubMed
      70. Pajor A, Moon DA, Wright SH. Sodium D-glucose cotransport in the gill of marine mussels: studies with intact tissue and brush-border membrane vesicles. J Membr Biol. 1989 Jan; 107(1):77-88. PMID: 2921769.
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      71. Pajor A, Wright SH. L-alanine uptake in brush border membrane vesicles from the gill of a marine bivalve. J Membr Biol. 1987; 96(3):209-23. PMID: 3612765.
        View in: PubMed
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