Ana Pajor

Title(s)Emeritus Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research Activities and Funding
    Metabolic role of the neuronal Na+-dependent citrate transporter implicated in epilepsy
    NIH R21NS104513May 15, 2018 - Apr 30, 2021
    Role: Principal Investigator
    Involvement of Na/Dicarboxylate Cotransporter in Aging
    NIH R03AG020810Apr 1, 2002 - Mar 31, 2004
    Role: Principal Investigator
    MECHANISM OF RENAL NA/DICARBOXYLATE TRANSPORT
    NIH K02DK002429Aug 10, 1996 - Jul 31, 2002
    Role: Principal Investigator
    Molecular Mechanism of Renal Na+ Dependent Cotransport
    NIH R01DK046269Apr 1, 1993 - Jun 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1. Biochemistry. 2017 08 22; 56(33):4432-4441. Colas C, Schlessinger A, Pajor AM. PMID: 28731330.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    2. Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors. Mol Pharmacol. 2016 Dec; 90(6):755-765. Pajor AM, de Oliveira CA, Song K, Huard K, Shanmugasundaram V, Erion DM. PMID: 27683012.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    3. Mutations in the Na(+)/citrate cotransporter NaCT (SLC13A5) in pediatric patients with epilepsy and developmental delay. Mol Med. 2016 05 26; 22. Klotz J, Porter BE, Colas C, Schlessinger A, Pajor AM. PMID: 27261973.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    4. Structure-Based Identification of Inhibitors for the SLC13 Family of Na(+)/Dicarboxylate Cotransporters. Biochemistry. 2015 Aug 11; 54(31):4900-8. Colas C, Pajor AM, Schlessinger A. PMID: 26176240.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    5. Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3. J Biol Chem. 2014 Jun 13; 289(24):16998-7008. Schlessinger A, Sun NN, Colas C, Pajor AM. PMID: 24808185.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    6. Localization of the calcium-regulated citrate transport process in proximal tubule cells. Urolithiasis. 2014 Jun; 42(3):209-19. Hering-Smith KS, Mao W, Schiro FR, Coleman-Barnett J, Pajor AM, Hamm LL. PMID: 24652587.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch. 2014 Jan; 466(1):119-30. Pajor AM. PMID: 24114175.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    8. Functional characterization of SdcF from Bacillus licheniformis, a homolog of the SLC13 Na?/dicarboxylate transporters. J Membr Biol. 2013 Sep; 246(9):705-15. Pajor AM, Sun NN, Leung A. PMID: 23979173.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    9. Nonsteroidal anti-inflammatory drugs and other anthranilic acids inhibit the Na(+)/dicarboxylate symporter from Staphylococcus aureus. Biochemistry. 2013 Apr 30; 52(17):2924-32. Pajor AM, Sun NN. PMID: 23566164.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Calcium sensitivity of dicarboxylate transport in cultured proximal tubule cells. Am J Physiol Renal Physiol. 2011 Feb; 300(2):F425-32. Hering-Smith KS, Schiro FR, Pajor AM, Hamm LL. PMID: 21123491.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function. Biochim Biophys Acta. 2011 Jun; 1808(6):1454-61. Pajor AM, Sun NN, Joshi AD, Randolph KM. PMID: 21073858.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Role of isoleucine-554 in lithium binding by the Na+/dicarboxylate cotransporter NaDC1. Biochemistry. 2010 Oct 19; 49(41):8937-43. Pajor AM, Sun NN. PMID: 20845974.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F704-11. Pajor AM, Sun NN. PMID: 20610529.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    14. Functional characterization of a Na(+)-coupled dicarboxylate transporter from Bacillus licheniformis. Biochim Biophys Acta. 2009 Dec; 1788(12):2489-96. Strickler MA, Hall JA, Gaiko O, Pajor AM. PMID: 19840771.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    15. Identification of conformationally sensitive amino acids in the Na(+)/dicarboxylate symporter (SdcS). Biochemistry. 2009 Apr 07; 48(13):3017-24. Joshi AD, Pajor AM. PMID: 19260674.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter. Biochemistry. 2008 Jan 22; 47(3):1087-93. Weerachayaphorn J, Pajor AM. PMID: 18161988.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Identification of transport pathways for citric acid cycle intermediates in the human colon carcinoma cell line, Caco-2. Biochim Biophys Acta. 2008 Apr; 1778(4):1051-9. Weerachayaphorn J, Pajor AM. PMID: 18194662.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar; 324(3):985-91. Pajor AM, Randolph KM, Kerner SA, Smith CD. PMID: 18063724.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    19. Inhibition of the Na+/dicarboxylate cotransporter by anthranilic acid derivatives. Mol Pharmacol. 2007 Nov; 72(5):1330-6. Pajor AM, Randolph KM. PMID: 17715401.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. Sodium-dependent extracellular accessibility of Lys-84 in the sodium/dicarboxylate cotransporter. J Biol Chem. 2007 Jul 13; 282(28):20213-20. Weerachayaphorn J, Pajor AM. PMID: 17504760.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Functional reconstitution of SdcS, a Na+-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2007 Feb; 189(3):880-5. Hall JA, Pajor AM. PMID: 17114260.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    22. Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter. Biochim Biophys Acta. 2006 Jun; 1758(6):781-8. Oshiro N, Pajor AM. PMID: 16787639.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    23. Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1. Biochemistry. 2006 Apr 04; 45(13):4231-9. Joshi AD, Pajor AM. PMID: 16566597.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Transmembrane helices 3 and 4 are involved in substrate recognition by the Na+/dicarboxylate cotransporter, NaDC1. Biochemistry. 2006 Feb 21; 45(7):2302-10. Oshiro N, King SC, Pajor AM. PMID: 16475819.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    25. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch. 2006 Feb; 451(5):597-605. Pajor AM. PMID: 16211368.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    26. Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2005 Aug; 187(15):5189-94. Hall JA, Pajor AM. PMID: 16030212.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    27. Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart. . 2005 Nov; 289(5):C1159-68. Oshiro N, Pajor AM. PMID: 15944208.
      View in: PubMed   Mentions:
    28. Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2005 May 13; 280(19):18728-35. Pajor AM, Randolph KM. PMID: 15774465.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    29. Absorption of alpha-ketoglutarate by the gastrointestinal tract of pigs. Comp Biochem Physiol A Mol Integr Physiol. 2004 Jun; 138(2):215-20. Buddington RK, Pajor A, Buddington KK, Pierzynowski S. PMID: 15275656.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. OKP cells express the Na-dicarboxylate cotransporter NaDC-1. . 2004 Jul; 287(1):C64-72. Aruga S, Pajor AM, Nakamura K, Liu L, Moe OW, Preisig PA, Alpern RJ. PMID: 14973148.
      View in: PubMed   Mentions:
    31. Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. . 2003 Nov; 285(5):C1188-96. Li H, Pajor AM. PMID: 12867358.
      View in: PubMed   Mentions:
    32. Serines 260 and 288 are involved in sulfate transport by hNaSi-1. J Biol Chem. 2003 Sep 26; 278(39):37204-12. Li H, Pajor AM. PMID: 12857732.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    33. Arginine-349 and aspartate-373 of the Na(+)/dicarboxylate cotransporter are conformationally sensitive residues. Biochemistry. 2002 Jan 22; 41(3):1083-90. Yao X, Pajor AM. PMID: 11790133.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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