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Ana Pajor

Title(s)Emeritus Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Metabolic role of the neuronal Na+-dependent citrate transporter implicated in epilepsy
    NIH R21NS104513May 15, 2018 - Apr 30, 2021
    Role: Principal Investigator
    Involvement of Na/Dicarboxylate Cotransporter in Aging
    NIH R03AG020810Apr 1, 2002 - Mar 31, 2004
    Role: Principal Investigator
    MECHANISM OF RENAL NA/DICARBOXYLATE TRANSPORT
    NIH K02DK002429Aug 10, 1996 - Jul 31, 2002
    Role: Principal Investigator
    Molecular Mechanism of Renal Na+ Dependent Cotransport
    NIH R01DK046269Apr 1, 1993 - Dec 31, 2006
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1. Biochemistry. 2017 08 22; 56(33):4432-4441. Colas C, Schlessinger A, Pajor AM. PMID: 28731330.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    2. Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors. Mol Pharmacol. 2016 Dec; 90(6):755-765. PMID: 27683012.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Mutations in the Na(+)/citrate cotransporter NaCT (SLC13A5) in pediatric patients with epilepsy and developmental delay. Mol Med. 2016 05 26; 22. PMID: 27261973.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    4. Structure-Based Identification of Inhibitors for the SLC13 Family of Na(+)/Dicarboxylate Cotransporters. Biochemistry. 2015 Aug 11; 54(31):4900-8. PMID: 26176240.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    5. Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3. J Biol Chem. 2014 Jun 13; 289(24):16998-7008. PMID: 24808185.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. Localization of the calcium-regulated citrate transport process in proximal tubule cells. Urolithiasis. 2014 Jun; 42(3):209-19. PMID: 24652587.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch. 2014 Jan; 466(1):119-30. PMID: 24114175.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    8. Functional characterization of SdcF from Bacillus licheniformis, a homolog of the SLC13 Na?/dicarboxylate transporters. J Membr Biol. 2013 Sep; 246(9):705-15. Pajor AM, Sun NN, Leung A. PMID: 23979173.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    9. Nonsteroidal anti-inflammatory drugs and other anthranilic acids inhibit the Na(+)/dicarboxylate symporter from Staphylococcus aureus. Biochemistry. 2013 Apr 30; 52(17):2924-32. PMID: 23566164.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Calcium sensitivity of dicarboxylate transport in cultured proximal tubule cells. Am J Physiol Renal Physiol. 2011 Feb; 300(2):F425-32. Hering-Smith KS, Schiro FR, Pajor AM, Hamm LL. PMID: 21123491.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function. Biochim Biophys Acta. 2011 Jun; 1808(6):1454-61. PMID: 21073858.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Role of isoleucine-554 in lithium binding by the Na+/dicarboxylate cotransporter NaDC1. Biochemistry. 2010 Oct 19; 49(41):8937-43. Pajor AM, Sun NN. PMID: 20845974.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F704-11. Pajor AM, Sun NN. PMID: 20610529.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    14. Functional characterization of a Na(+)-coupled dicarboxylate transporter from Bacillus licheniformis. Biochim Biophys Acta. 2009 Dec; 1788(12):2489-96. Strickler MA, Hall JA, Gaiko O, Pajor AM. PMID: 19840771.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    15. Identification of conformationally sensitive amino acids in the Na(+)/dicarboxylate symporter (SdcS). Biochemistry. 2009 Apr 07; 48(13):3017-24. Joshi AD, Pajor AM. PMID: 19260674.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter. Biochemistry. 2008 Jan 22; 47(3):1087-93. Weerachayaphorn J, Pajor AM. PMID: 18161988.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Identification of transport pathways for citric acid cycle intermediates in the human colon carcinoma cell line, Caco-2. Biochim Biophys Acta. 2008 Apr; 1778(4):1051-9. Weerachayaphorn J, Pajor AM. PMID: 18194662.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar; 324(3):985-91. Pajor AM, Randolph KM, Kerner SA, Smith CD. PMID: 18063724.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    19. Inhibition of the Na+/dicarboxylate cotransporter by anthranilic acid derivatives. Mol Pharmacol. 2007 Nov; 72(5):1330-6. Pajor AM, Randolph KM. PMID: 17715401.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. Sodium-dependent extracellular accessibility of Lys-84 in the sodium/dicarboxylate cotransporter. J Biol Chem. 2007 Jul 13; 282(28):20213-20. Weerachayaphorn J, Pajor AM. PMID: 17504760.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Functional reconstitution of SdcS, a Na+-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2007 Feb; 189(3):880-5. Hall JA, Pajor AM. PMID: 17114260.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    22. Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter. Biochim Biophys Acta. 2006 Jun; 1758(6):781-8. Oshiro N, Pajor AM. PMID: 16787639.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    23. Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1. Biochemistry. 2006 Apr 04; 45(13):4231-9. Joshi AD, Pajor AM. PMID: 16566597.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Transmembrane helices 3 and 4 are involved in substrate recognition by the Na+/dicarboxylate cotransporter, NaDC1. Biochemistry. 2006 Feb 21; 45(7):2302-10. Oshiro N, King SC, Pajor AM. PMID: 16475819.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    25. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch. 2006 Feb; 451(5):597-605. Pajor AM. PMID: 16211368.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    26. Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2005 Aug; 187(15):5189-94. Hall JA, Pajor AM. PMID: 16030212.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    27. Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart. . 2005 Nov; 289(5):C1159-68. Oshiro N, Pajor AM. PMID: 15944208.
      View in: PubMed   Mentions:
    28. Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2005 May 13; 280(19):18728-35. Pajor AM, Randolph KM. PMID: 15774465.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. Absorption of alpha-ketoglutarate by the gastrointestinal tract of pigs. Comp Biochem Physiol A Mol Integr Physiol. 2004 Jun; 138(2):215-20. Buddington RK, Pajor A, Buddington KK, Pierzynowski S. PMID: 15275656.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. OKP cells express the Na-dicarboxylate cotransporter NaDC-1. . 2004 Jul; 287(1):C64-72. Aruga S, Pajor AM, Nakamura K, Liu L, Moe OW, Preisig PA, Alpern RJ. PMID: 14973148.
      View in: PubMed   Mentions:
    31. Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. . 2003 Nov; 285(5):C1188-96. Li H, Pajor AM. PMID: 12867358.
      View in: PubMed   Mentions:
    32. Serines 260 and 288 are involved in sulfate transport by hNaSi-1. J Biol Chem. 2003 Sep 26; 278(39):37204-12. Li H, Pajor AM. PMID: 12857732.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    33. Arginine-349 and aspartate-373 of the Na(+)/dicarboxylate cotransporter are conformationally sensitive residues. Biochemistry. 2002 Jan 22; 41(3):1083-90. Yao X, Pajor AM. PMID: 11790133.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Functional characterization of CitM, the Mg2+-citrate transporter. J Membr Biol. 2002 Jan 01; 185(1):9-16. Li H, Pajor AM. PMID: 11891560.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    35. Conformationally sensitive residues in transmembrane domain 9 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2001 Aug 10; 276(32):29961-8. Pajor AM. PMID: 11399753.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    36. Cloning and functional characterization of a high-affinity Na(+)/dicarboxylate cotransporter from mouse brain. . 2001 May; 280(5):C1215-23. Pajor AM, Gangula R, Yao X. PMID: 11287335.
      View in: PubMed   Mentions:
    37. Topology of the Na(+)/dicarboxylate cotransporter: the N-terminus and hydrophilic loop 4 are located intracellularly. Biochim Biophys Acta. 2001 Mar 09; 1511(1):80-9. Zhang FF, Pajor AM. PMID: 11248207.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Role of cationic amino acids in the Na+/dicarboxylate co-transporter NaDC-1. Biochem J. 2000 Sep 15; 350 Pt 3:677-83. Pajor AM, Kahn ES, Gangula R. PMID: 10970779.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    39. Molecular cloning, chromosomal organization, and functional characterization of a sodium-dicarboxylate cotransporter from mouse kidney. Am J Physiol Renal Physiol. 2000 Sep; 279(3):F482-90. Pajor AM, Sun NN. PMID: 10966927.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    40. Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney. Kidney Int. 2000 Jul; 58(1):206-15. Aruga S, Wehrli S, Kaissling B, Moe OW, Preisig PA, Pajor AM, Alpern RJ. PMID: 10886565.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    41. The transport properties of the human renal Na(+)- dicarboxylate cotransporter under voltage-clamp conditions. Am J Physiol Renal Physiol. 2000 Jul; 279(1):F54-64. Yao X, Pajor AM. PMID: 10894787.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    42. Water transport by the renal Na(+)-dicarboxylate cotransporter. Am J Physiol Renal Physiol. 2000 May; 278(5):F777-83. Meinild AK, Loo DD, Pajor AM, Zeuthen T, Wright EM. PMID: 10807589.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    43. Molecular properties of sodium/dicarboxylate cotransporters. J Membr Biol. 2000 May 01; 175(1):1-8. Pajor AM. PMID: 10811962.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    44. Cysteine residues in the Na+/dicarboxylate co-transporter, NaDC-1. Biochem J. 1999 Nov 15; 344 Pt 1:205-9. Pajor AM, Krajewski SJ, Sun N, Gangula R. PMID: 10548552.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. Protein kinase C-mediated regulation of the renal Na(+)/dicarboxylate cotransporter, NaDC-1. Biochim Biophys Acta. 1999 Aug 20; 1420(1-2):223-30. Pajor AM, Sun N. PMID: 10446305.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. Acidic residues involved in cation and substrate interactions in the Na+/dicarboxylate cotransporter, NaDC-1. Biochemistry. 1999 Jun 08; 38(23):7524-31. Griffith DA, Pajor AM. PMID: 10360950.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    47. Determinants of substrate and cation affinities in the Na+/dicarboxylate cotransporter. Biochemistry. 1999 May 11; 38(19):6151-6. Kahn ES, Pajor AM. PMID: 10320342.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    48. Citrate transport by the kidney and intestine. Semin Nephrol. 1999 Mar; 19(2):195-200. Pajor AM. PMID: 10192253.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    49. Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter. J Biol Chem. 1999 Feb 05; 274(6):3422-9. Kekuda R, Wang H, Huang W, Pajor AM, Leibach FH, Devoe LD, Prasad PD, Ganapathy V. PMID: 9920886.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    50. Sodium-coupled transporters for Krebs cycle intermediates. Annu Rev Physiol. 1999; 61:663-82. Pajor AM. PMID: 10099705.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    51. Sequence of a pyrimidine-selective Na+/nucleoside cotransporter from pig kidney, pkCNT1. Biochim Biophys Acta. 1998 Dec 09; 1415(1):266-9. Pajor AM. PMID: 9858747.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    52. Sodium and lithium interactions with the Na+/Dicarboxylate cotransporter. J Biol Chem. 1998 Jul 24; 273(30):18923-9. Pajor AM, Hirayama BA, Loo DD. PMID: 9668069.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    53. Mutational analysis of histidine residues in the rabbit Na+/dicarboxylate co-transporter NaDC-1. Biochem J. 1998 Apr 01; 331 ( Pt 1):257-64. Pajor AM, Sun N, Valmonte HG. PMID: 9512488.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    54. The substrate recognition domain in the Na+/dicarboxylate and Na+/sulfate cotransporters is located in the carboxy-terminal portion of the protein. Biochim Biophys Acta. 1998 Mar 06; 1370(1):98-106. Pajor AM, Sun N, Bai L, Markovich D, Sule P. PMID: 9518567.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    55. Expression cloning of NaDC-2, an intestinal Na(+)- or Li(+)-dependent dicarboxylate transporter. Am J Physiol. 1997 Aug; 273(2 Pt 1):G267-74. Bai L, Pajor AM. PMID: 9277403.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    56. Characterization of the rabbit renal Na(+)-dicarboxylate cotransporter using antifusion protein antibodies. Am J Physiol. 1996 Dec; 271(6 Pt 1):C1808-16. Pajor AM, Sun N. PMID: 8997180.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    57. Functional differences between rabbit and human Na(+)-dicarboxylate cotransporters, NaDC-1 and hNaDC-1. Am J Physiol. 1996 Nov; 271(5 Pt 2):F1093-9. Pajor AM, Sun N. PMID: 8946005.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    58. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am J Physiol. 1996 Apr; 270(4 Pt 2):F642-8. Pajor AM. PMID: 8967342.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    59. Expression of the renal Na+/dicarboxylate cotransporter, NaDC-1, in COS-7 cells. Pflugers Arch. 1996 Feb; 431(4):645-51. Pajor AM, Valmonte HG. PMID: 8596711.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    60. Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter. J Biol Chem. 1995 Mar 17; 270(11):5779-85. Pajor AM. PMID: 7890707.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    61. Sequence of a putative transporter from rabbit kidney related to the Na+/glucose cotransporter gene family. Biochim Biophys Acta. 1994 Sep 14; 1194(2):349-51. Pajor AM. PMID: 7918548.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    62. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol. 1992 Sep; 263(3 Pt 2):F459-65. Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA. PMID: 1415574.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    63. Molecular evidence for two renal Na+/glucose cotransporters. Biochim Biophys Acta. 1992 Apr 29; 1106(1):216-20. Pajor AM, Hirayama BA, Wright EM. PMID: 1581333.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    64. Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family. J Biol Chem. 1992 Feb 25; 267(6):3557-60. Pajor AM, Wright EM. PMID: 1740408.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    65. High-affinity phlorizin binding in Mytilus gill. Biochim Biophys Acta. 1992 Jan 31; 1103(2):212-8. Wright SH, Pajor AM, Moon DA, Wunz TM. PMID: 1543705.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    66. Expression of mammalian renal transporters in Xenopus laevis oocytes. Arch Biochem Biophys. 1990 Nov 15; 283(1):130-4. Coady MJ, Pajor AM, Toloza EM, Wright EM. PMID: 2241165.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    67. Sequence homologies among intestinal and renal Na+/glucose cotransporters. Am J Physiol. 1990 Oct; 259(4 Pt 1):C605-10. Coady MJ, Pajor AM, Wright EM. PMID: 2221040.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    68. Mechanisms of integumental amino acid transport in marine bivalves. Am J Physiol. 1989 Sep; 257(3 Pt 2):R473-83. Wright SH, Pajor AM. PMID: 2506769.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    69. Molecular genetics of the human Na+/glucose cotransporter. Klin Wochenschr. 1989 Sep 01; 67(17):843-6. Hediger MA, Turk E, Pajor AM, Wright EM. PMID: 2681963.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    70. Uptake of lysine and proline via separate alpha-neutral amino acid transport pathways in Mytilus gill brush border membranes. J Membr Biol. 1989 Mar; 107(3):237-47. Pajor AM, Wright SH. PMID: 2497258.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    71. Sodium D-glucose cotransport in the gill of marine mussels: studies with intact tissue and brush-border membrane vesicles. J Membr Biol. 1989 Jan; 107(1):77-88. Pajor AM, Moon DA, Wright SH. PMID: 2921769.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    72. L-alanine uptake in brush border membrane vesicles from the gill of a marine bivalve. J Membr Biol. 1987; 96(3):209-23. Pajor AM, Wright SH. PMID: 3612765.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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