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Ana Pajor
Title
Professor
School
University of California, San Diego
Department
School of Pharmacy and Pharmaceutical Science
Address
9500 Gilman Drive #0714
CA La Jolla 92093
Phone
858-822-7806
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Research
Research Activities and Funding
Involvement of Na/Dicarboxylate Cotransporter in Aging
NIH/NIA
R03AG020810
Apr 1, 2002 - Mar 31, 2004
Role: Principal Investigator
MECHANISM OF RENAL NA/DICARBOXYLATE TRANSPORT
NIH/NIDDK
K02DK002429
Aug 10, 1996 - Jul 31, 2002
Role: Principal Investigator
Molecular Mechanism of Renal Na+ Dependent Cotransport
NIH/NIDDK
R01DK046269
Apr 1, 1993 - Jun 30, 2012
Role: Principal Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Colas C, Schlessinger A,
Pajor A
. Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1. Biochemistry. 2017 Aug 22; 56(33):4432-4441. PMID: 28731330.
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PubMed
Pajor A
, de Oliveira CA, Song K, Huard K, Shanmugasundaram V, Erion DM. Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors. Mol Pharmacol. 2016 Dec; 90(6):755-765. PMID: 27683012.
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PubMed
Colas C,
Pajor A
, Schlessinger A. Structure-Based Identification of Inhibitors for the SLC13 Family of Na(+)/Dicarboxylate Cotransporters. Biochemistry. 2015 Aug 11; 54(31):4900-8. PMID: 26176240; PMCID: PMC4781755.
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PubMed
,
PubMed Central
Schlessinger A, Sun NN, Colas C,
Pajor A
. Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3. J Biol Chem. 2014 Jun 13; 289(24):16998-7008. PMID: 24808185; PMCID: PMC4059142.
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PubMed
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PubMed Central
Hering-Smith KS, Mao W, Schiro FR, Coleman-Barnett J,
Pajor A
, Hamm LL. Localization of the calcium-regulated citrate transport process in proximal tubule cells. Urolithiasis. 2014 Jun; 42(3):209-19. PMID: 24652587; PMCID: PMC4106718.
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PubMed
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PubMed Central
Pajor A
. Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch. 2014 Jan; 466(1):119-30. PMID: 24114175.
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PubMed
Pajor A
, Sun NN, Leung A. Functional characterization of SdcF from Bacillus licheniformis, a homolog of the SLC13 Na?/dicarboxylate transporters. J Membr Biol. 2013 Sep; 246(9):705-15. PMID: 23979173.
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PubMed
Pajor A
, Sun NN. Nonsteroidal anti-inflammatory drugs and other anthranilic acids inhibit the Na(+)/dicarboxylate symporter from Staphylococcus aureus. Biochemistry. 2013 Apr 30; 52(17):2924-32. PMID: 23566164.
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PubMed
Hering-Smith KS, Schiro FR,
Pajor A
, Hamm LL. Calcium sensitivity of dicarboxylate transport in cultured proximal tubule cells. Am J Physiol Renal Physiol. 2011 Feb; 300(2):F425-32. PMID: 21123491; PMCID: PMC3043994.
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PubMed
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PubMed Central
Pajor A
, Sun NN, Joshi AD, Randolph KM. Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function. Biochim Biophys Acta. 2011 Jun; 1808(6):1454-61. PMID: 21073858; PMCID: PMC3046213.
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PubMed Central
Pajor A
, Sun NN. Role of isoleucine-554 in lithium binding by the Na+/dicarboxylate cotransporter NaDC1. Biochemistry. 2010 Oct 19; 49(41):8937-43. PMID: 20845974; PMCID: PMC2956517.
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PubMed
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PubMed Central
Pajor A
, Sun NN. Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F704-11. PMID: 20610529; PMCID: PMC2957249.
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PubMed
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PubMed Central
Strickler MA, Hall JA, Gaiko O,
Pajor A
. Functional characterization of a Na(+)-coupled dicarboxylate transporter from Bacillus licheniformis. Biochim Biophys Acta. 2009 Dec; 1788(12):2489-96. PMID: 19840771; PMCID: PMC2787743.
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PubMed
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PubMed Central
Joshi AD,
Pajor A
. Identification of conformationally sensitive amino acids in the Na(+)/dicarboxylate symporter (SdcS). Biochemistry. 2009 Apr 07; 48(13):3017-24. PMID: 19260674; PMCID: PMC2666955.
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PubMed
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PubMed Central
Weerachayaphorn J,
Pajor A
. Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter. Biochemistry. 2008 Jan 22; 47(3):1087-93. PMID: 18161988; PMCID: PMC2570185.
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PubMed
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PubMed Central
Weerachayaphorn J,
Pajor A
. Identification of transport pathways for citric acid cycle intermediates in the human colon carcinoma cell line, Caco-2. Biochim Biophys Acta. 2008 Apr; 1778(4):1051-9. PMID: 18194662; PMCID: PMC2323910.
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PubMed
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PubMed Central
Pajor A
, Randolph KM, Kerner SA, Smith CD. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar; 324(3):985-91. PMID: 18063724.
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PubMed
Pajor A
, Randolph KM. Inhibition of the Na+/dicarboxylate cotransporter by anthranilic acid derivatives. Mol Pharmacol. 2007 Nov; 72(5):1330-6. PMID: 17715401.
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PubMed
Weerachayaphorn J,
Pajor A
. Sodium-dependent extracellular accessibility of Lys-84 in the sodium/dicarboxylate cotransporter. J Biol Chem. 2007 Jul 13; 282(28):20213-20. PMID: 17504760; PMCID: PMC2864014.
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PubMed
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PubMed Central
Hall JA,
Pajor A
. Functional reconstitution of SdcS, a Na+-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2007 Feb; 189(3):880-5. PMID: 17114260; PMCID: PMC1797332.
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PubMed
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PubMed Central
Oshiro N,
Pajor A
. Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter. Biochim Biophys Acta. 2006 Jun; 1758(6):781-8. PMID: 16787639; PMCID: PMC1622917.
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PubMed
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PubMed Central
Joshi AD,
Pajor A
. Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1. Biochemistry. 2006 Apr 04; 45(13):4231-9. PMID: 16566597; PMCID: PMC2547120.
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PubMed
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PubMed Central
Oshiro N, King SC,
Pajor A
. Transmembrane helices 3 and 4 are involved in substrate recognition by the Na+/dicarboxylate cotransporter, NaDC1. Biochemistry. 2006 Feb 21; 45(7):2302-10. PMID: 16475819.
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PubMed
Pajor A
. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch. 2006 Feb; 451(5):597-605. PMID: 16211368; PMCID: PMC1866268.
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PubMed
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PubMed Central
Hall JA,
Pajor A
. Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2005 Aug; 187(15):5189-94. PMID: 16030212; PMCID: PMC1196027.
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PubMed
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PubMed Central
Oshiro N,
Pajor A
. Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1159-68. PMID: 15944208.
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PubMed
Pajor A
, Randolph KM. Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2005 May 13; 280(19):18728-35. PMID: 15774465; PMCID: PMC1224748.
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PubMed
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PubMed Central
Buddington RK,
Pajor A
, Buddington KK, Pierzynowski S. Absorption of alpha-ketoglutarate by the gastrointestinal tract of pigs. Comp Biochem Physiol A Mol Integr Physiol. 2004 Jun; 138(2):215-20. PMID: 15275656.
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PubMed
Aruga S,
Pajor A
, Nakamura K, Liu L, Moe OW, Preisig PA, Alpern RJ. OKP cells express the Na-dicarboxylate cotransporter NaDC-1. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C64-72. PMID: 14973148.
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PubMed
Li H,
Pajor A
. Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. Am J Physiol Cell Physiol. 2003 Nov; 285(5):C1188-96. PMID: 12867358.
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PubMed
Li H,
Pajor A
. Serines 260 and 288 are involved in sulfate transport by hNaSi-1. J Biol Chem. 2003 Sep 26; 278(39):37204-12. PMID: 12857732.
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PubMed
Yao X,
Pajor A
. Arginine-349 and aspartate-373 of the Na(+)/dicarboxylate cotransporter are conformationally sensitive residues. Biochemistry. 2002 Jan 22; 41(3):1083-90. PMID: 11790133.
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PubMed
Li H,
Pajor A
. Functional characterization of CitM, the Mg2+-citrate transporter. J Membr Biol. 2002 Jan 01; 185(1):9-16. PMID: 11891560.
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PubMed
Pajor A
. Conformationally sensitive residues in transmembrane domain 9 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2001 Aug 10; 276(32):29961-8. PMID: 11399753.
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PubMed
Pajor A
, Gangula R, Yao X. Cloning and functional characterization of a high-affinity Na(+)/dicarboxylate cotransporter from mouse brain. Am J Physiol Cell Physiol. 2001 May; 280(5):C1215-23. PMID: 11287335.
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PubMed
Zhang FF,
Pajor A
. Topology of the Na(+)/dicarboxylate cotransporter: the N-terminus and hydrophilic loop 4 are located intracellularly. Biochim Biophys Acta. 2001 Mar 09; 1511(1):80-9. PMID: 11248207.
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PubMed
Pajor A
, Kahn ES, Gangula R. Role of cationic amino acids in the Na+/dicarboxylate co-transporter NaDC-1. Biochem J. 2000 Sep 15; 350 Pt 3:677-83. PMID: 10970779; PMCID: PMC1221297.
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PubMed
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PubMed Central
Pajor A
, Sun NN. Molecular cloning, chromosomal organization, and functional characterization of a sodium-dicarboxylate cotransporter from mouse kidney. Am J Physiol Renal Physiol. 2000 Sep; 279(3):F482-90. PMID: 10966927.
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PubMed
Aruga S, Wehrli S, Kaissling B, Moe OW, Preisig PA,
Pajor A
, Alpern RJ. Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney. Kidney Int. 2000 Jul; 58(1):206-15. PMID: 10886565.
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PubMed
Yao X,
Pajor A
. The transport properties of the human renal Na(+)- dicarboxylate cotransporter under voltage-clamp conditions. Am J Physiol Renal Physiol. 2000 Jul; 279(1):F54-64. PMID: 10894787.
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PubMed
Meinild AK, Loo DD,
Pajor A
, Zeuthen T, Wright EM. Water transport by the renal Na(+)-dicarboxylate cotransporter. Am J Physiol Renal Physiol. 2000 May; 278(5):F777-83. PMID: 10807589.
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PubMed
Pajor A
. Molecular properties of sodium/dicarboxylate cotransporters. J Membr Biol. 2000 May 01; 175(1):1-8. PMID: 10811962.
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PubMed
Pajor A
, Krajewski SJ, Sun N, Gangula R. Cysteine residues in the Na+/dicarboxylate co-transporter, NaDC-1. Biochem J. 1999 Nov 15; 344 Pt 1:205-9. PMID: 10548552; PMCID: PMC1220632.
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PubMed Central
Pajor A
, Sun N. Protein kinase C-mediated regulation of the renal Na(+)/dicarboxylate cotransporter, NaDC-1. Biochim Biophys Acta. 1999 Aug 20; 1420(1-2):223-30. PMID: 10446305.
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PubMed
Griffith DA,
Pajor A
. Acidic residues involved in cation and substrate interactions in the Na+/dicarboxylate cotransporter, NaDC-1. Biochemistry. 1999 Jun 08; 38(23):7524-31. PMID: 10360950.
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PubMed
Kahn ES,
Pajor A
. Determinants of substrate and cation affinities in the Na+/dicarboxylate cotransporter. Biochemistry. 1999 May 11; 38(19):6151-6. PMID: 10320342.
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PubMed
Pajor A
. Citrate transport by the kidney and intestine. Semin Nephrol. 1999 Mar; 19(2):195-200. PMID: 10192253.
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PubMed
Kekuda R, Wang H, Huang W,
Pajor A
, Leibach FH, Devoe LD, Prasad PD, Ganapathy V. Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter. J Biol Chem. 1999 Feb 05; 274(6):3422-9. PMID: 9920886.
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PubMed
Pajor A
. Sodium-coupled transporters for Krebs cycle intermediates. Annu Rev Physiol. 1999; 61:663-82. PMID: 10099705.
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PubMed
Pajor A
. Sequence of a pyrimidine-selective Na+/nucleoside cotransporter from pig kidney, pkCNT1. Biochim Biophys Acta. 1998 Dec 09; 1415(1):266-9. PMID: 9858747.
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PubMed
Pajor A
, Hirayama BA, Loo DD. Sodium and lithium interactions with the Na+/Dicarboxylate cotransporter. J Biol Chem. 1998 Jul 24; 273(30):18923-9. PMID: 9668069.
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PubMed
Pajor A
, Sun N, Valmonte HG. Mutational analysis of histidine residues in the rabbit Na+/dicarboxylate co-transporter NaDC-1. Biochem J. 1998 Apr 01; 331 ( Pt 1):257-64. PMID: 9512488; PMCID: PMC1219347.
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PubMed Central
Pajor A
, Sun N, Bai L, Markovich D, Sule P. The substrate recognition domain in the Na+/dicarboxylate and Na+/sulfate cotransporters is located in the carboxy-terminal portion of the protein. Biochim Biophys Acta. 1998 Mar 06; 1370(1):98-106. PMID: 9518567.
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PubMed
Bai L,
Pajor A
. Expression cloning of NaDC-2, an intestinal Na(+)- or Li(+)-dependent dicarboxylate transporter. Am J Physiol. 1997 Aug; 273(2 Pt 1):G267-74. PMID: 9277403.
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Pajor A
, Sun N. Characterization of the rabbit renal Na(+)-dicarboxylate cotransporter using antifusion protein antibodies. Am J Physiol. 1996 Dec; 271(6 Pt 1):C1808-16. PMID: 8997180.
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PubMed
Pajor A
, Sun N. Functional differences between rabbit and human Na(+)-dicarboxylate cotransporters, NaDC-1 and hNaDC-1. Am J Physiol. 1996 Nov; 271(5 Pt 2):F1093-9. PMID: 8946005.
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PubMed
Pajor A
. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am J Physiol. 1996 Apr; 270(4 Pt 2):F642-8. PMID: 8967342.
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PubMed
Pajor A
, Valmonte HG. Expression of the renal Na+/dicarboxylate cotransporter, NaDC-1, in COS-7 cells. Pflugers Arch. 1996 Feb; 431(4):645-51. PMID: 8596711.
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PubMed
Pajor A
. Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter. J Biol Chem. 1995 Mar 17; 270(11):5779-85. PMID: 7890707.
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PubMed
Pajor A
. Sequence of a putative transporter from rabbit kidney related to the Na+/glucose cotransporter gene family. Biochim Biophys Acta. 1994 Sep 14; 1194(2):349-51. PMID: 7918548.
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PubMed
Wells RG,
Pajor A
, Kanai Y, Turk E, Wright EM, Hediger MA. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol. 1992 Sep; 263(3 Pt 2):F459-65. PMID: 1415574.
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Pajor A
, Hirayama BA, Wright EM. Molecular evidence for two renal Na+/glucose cotransporters. Biochim Biophys Acta. 1992 Apr 29; 1106(1):216-20. PMID: 1581333.
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PubMed
Pajor A
, Wright EM. Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family. J Biol Chem. 1992 Feb 25; 267(6):3557-60. PMID: 1740408.
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PubMed
Wright SH,
Pajor A
, Moon DA, Wunz TM. High-affinity phlorizin binding in Mytilus gill. Biochim Biophys Acta. 1992 Jan 31; 1103(2):212-8. PMID: 1543705.
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PubMed
Coady MJ,
Pajor A
, Toloza EM, Wright EM. Expression of mammalian renal transporters in Xenopus laevis oocytes. Arch Biochem Biophys. 1990 Nov 15; 283(1):130-4. PMID: 2241165.
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PubMed
Coady MJ,
Pajor A
, Wright EM. Sequence homologies among intestinal and renal Na+/glucose cotransporters. Am J Physiol. 1990 Oct; 259(4 Pt 1):C605-10. PMID: 2221040.
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PubMed
Wright SH,
Pajor A
. Mechanisms of integumental amino acid transport in marine bivalves. Am J Physiol. 1989 Sep; 257(3 Pt 2):R473-83. PMID: 2506769.
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PubMed
Hediger MA, Turk E,
Pajor A
, Wright EM. Molecular genetics of the human Na+/glucose cotransporter. Klin Wochenschr. 1989 Sep 01; 67(17):843-6. PMID: 2681963.
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PubMed
Pajor A
, Wright SH. Uptake of lysine and proline via separate alpha-neutral amino acid transport pathways in Mytilus gill brush border membranes. J Membr Biol. 1989 Mar; 107(3):237-47. PMID: 2497258.
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PubMed
Pajor A
, Moon DA, Wright SH. Sodium D-glucose cotransport in the gill of marine mussels: studies with intact tissue and brush-border membrane vesicles. J Membr Biol. 1989 Jan; 107(1):77-88. PMID: 2921769.
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PubMed
Pajor A
, Wright SH. L-alanine uptake in brush border membrane vesicles from the gill of a marine bivalve. J Membr Biol. 1987; 96(3):209-23. PMID: 3612765.
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PubMed
View timeline visualization
Year
Publications
1987
1
1989
4
1990
2
1992
4
1994
1
1995
1
1996
4
1997
1
1998
4
1999
7
2000
6
2001
3
2002
2
2003
2
2004
2
2005
4
2006
4
2007
5
2009
2
2010
4
2013
3
2014
2
2015
1
2016
1
2017
1
Ana's Networks
Concepts
Derived automatically from this person's publications.
Carrier Proteins
Organic Anion Transporters, Sodium-Dependent
Dicarboxylic Acid Transporters
Symporters
Sodium
See all (250) concept(s)
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Hall, Jason
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