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Ana Pajor

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0714
La Jolla CA 92093
Phone858-822-7806
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    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic role of the neuronal Na+-dependent citrate transporter implicated in epilepsy
    NIH/NINDS R21NS104513May 15, 2018 - Apr 30, 2020
    Role: Principal Investigator
    Involvement of Na/Dicarboxylate Cotransporter in Aging
    NIH/NIA R03AG020810Apr 1, 2002 - Mar 31, 2004
    Role: Principal Investigator
    MECHANISM OF RENAL NA/DICARBOXYLATE TRANSPORT
    NIH/NIDDK K02DK002429Aug 10, 1996 - Jul 31, 2002
    Role: Principal Investigator
    Molecular Mechanism of Renal Na+ Dependent Cotransport
    NIH/NIDDK R01DK046269Apr 1, 1993 - Jun 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Colas C, Schlessinger A, Pajor A. Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1. Biochemistry. 2017 08 22; 56(33):4432-4441. PMID: 28731330.
      View in: PubMed
    2. Pajor A, de Oliveira CA, Song K, Huard K, Shanmugasundaram V, Erion DM. Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors. Mol Pharmacol. 2016 Dec; 90(6):755-765. PMID: 27683012.
      View in: PubMed
    3. Klotz J, Porter BE, Colas C, Schlessinger A, Pajor A. Mutations in the Na(+)/citrate cotransporter NaCT (SLC13A5) in pediatric patients with epilepsy and developmental delay. Mol Med. 2016 05 26; 22. PMID: 27261973.
      View in: PubMed
    4. Colas C, Pajor A, Schlessinger A. Structure-Based Identification of Inhibitors for the SLC13 Family of Na(+)/Dicarboxylate Cotransporters. Biochemistry. 2015 Aug 11; 54(31):4900-8. PMID: 26176240; PMCID: PMC4781755.
      View in: PubMed, PubMed Central
    5. Schlessinger A, Sun NN, Colas C, Pajor A. Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3. J Biol Chem. 2014 Jun 13; 289(24):16998-7008. PMID: 24808185; PMCID: PMC4059142.
      View in: PubMed, PubMed Central
    6. Hering-Smith KS, Mao W, Schiro FR, Coleman-Barnett J, Pajor A, Hamm LL. Localization of the calcium-regulated citrate transport process in proximal tubule cells. Urolithiasis. 2014 Jun; 42(3):209-19. PMID: 24652587; PMCID: PMC4106718.
      View in: PubMed, PubMed Central
    7. Pajor A. Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family. Pflugers Arch. 2014 Jan; 466(1):119-30. PMID: 24114175.
      View in: PubMed
    8. Pajor A, Sun NN, Leung A. Functional characterization of SdcF from Bacillus licheniformis, a homolog of the SLC13 Na?/dicarboxylate transporters. J Membr Biol. 2013 Sep; 246(9):705-15. PMID: 23979173.
      View in: PubMed
    9. Pajor A, Sun NN. Nonsteroidal anti-inflammatory drugs and other anthranilic acids inhibit the Na(+)/dicarboxylate symporter from Staphylococcus aureus. Biochemistry. 2013 Apr 30; 52(17):2924-32. PMID: 23566164.
      View in: PubMed
    10. Hering-Smith KS, Schiro FR, Pajor A, Hamm LL. Calcium sensitivity of dicarboxylate transport in cultured proximal tubule cells. Am J Physiol Renal Physiol. 2011 Feb; 300(2):F425-32. PMID: 21123491; PMCID: PMC3043994.
      View in: PubMed, PubMed Central
    11. Pajor A, Sun NN, Joshi AD, Randolph KM. Transmembrane helix 7 in the Na+/dicarboxylate cotransporter 1 is an outer helix that contains residues critical for function. Biochim Biophys Acta. 2011 Jun; 1808(6):1454-61. PMID: 21073858; PMCID: PMC3046213.
      View in: PubMed, PubMed Central
    12. Pajor A, Sun NN. Role of isoleucine-554 in lithium binding by the Na+/dicarboxylate cotransporter NaDC1. Biochemistry. 2010 Oct 19; 49(41):8937-43. PMID: 20845974; PMCID: PMC2956517.
      View in: PubMed, PubMed Central
    13. Pajor A, Sun NN. Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F704-11. PMID: 20610529; PMCID: PMC2957249.
      View in: PubMed, PubMed Central
    14. Strickler MA, Hall JA, Gaiko O, Pajor A. Functional characterization of a Na(+)-coupled dicarboxylate transporter from Bacillus licheniformis. Biochim Biophys Acta. 2009 Dec; 1788(12):2489-96. PMID: 19840771; PMCID: PMC2787743.
      View in: PubMed, PubMed Central
    15. Joshi AD, Pajor A. Identification of conformationally sensitive amino acids in the Na(+)/dicarboxylate symporter (SdcS). Biochemistry. 2009 Apr 07; 48(13):3017-24. PMID: 19260674; PMCID: PMC2666955.
      View in: PubMed, PubMed Central
    16. Weerachayaphorn J, Pajor A. Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter. Biochemistry. 2008 Jan 22; 47(3):1087-93. PMID: 18161988; PMCID: PMC2570185.
      View in: PubMed, PubMed Central
    17. Weerachayaphorn J, Pajor A. Identification of transport pathways for citric acid cycle intermediates in the human colon carcinoma cell line, Caco-2. Biochim Biophys Acta. 2008 Apr; 1778(4):1051-9. PMID: 18194662; PMCID: PMC2323910.
      View in: PubMed, PubMed Central
    18. Pajor A, Randolph KM, Kerner SA, Smith CD. Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters. J Pharmacol Exp Ther. 2008 Mar; 324(3):985-91. PMID: 18063724.
      View in: PubMed
    19. Pajor A, Randolph KM. Inhibition of the Na+/dicarboxylate cotransporter by anthranilic acid derivatives. Mol Pharmacol. 2007 Nov; 72(5):1330-6. PMID: 17715401.
      View in: PubMed
    20. Weerachayaphorn J, Pajor A. Sodium-dependent extracellular accessibility of Lys-84 in the sodium/dicarboxylate cotransporter. J Biol Chem. 2007 Jul 13; 282(28):20213-20. PMID: 17504760; PMCID: PMC2864014.
      View in: PubMed, PubMed Central
    21. Hall JA, Pajor A. Functional reconstitution of SdcS, a Na+-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2007 Feb; 189(3):880-5. PMID: 17114260; PMCID: PMC1797332.
      View in: PubMed, PubMed Central
    22. Oshiro N, Pajor A. Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter. Biochim Biophys Acta. 2006 Jun; 1758(6):781-8. PMID: 16787639; PMCID: PMC1622917.
      View in: PubMed, PubMed Central
    23. Joshi AD, Pajor A. Role of conserved prolines in the structure and function of the Na+/dicarboxylate cotransporter 1, NaDC1. Biochemistry. 2006 Apr 04; 45(13):4231-9. PMID: 16566597; PMCID: PMC2547120.
      View in: PubMed, PubMed Central
    24. Oshiro N, King SC, Pajor A. Transmembrane helices 3 and 4 are involved in substrate recognition by the Na+/dicarboxylate cotransporter, NaDC1. Biochemistry. 2006 Feb 21; 45(7):2302-10. PMID: 16475819.
      View in: PubMed
    25. Pajor A. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch. 2006 Feb; 451(5):597-605. PMID: 16211368; PMCID: PMC1866268.
      View in: PubMed, PubMed Central
    26. Hall JA, Pajor A. Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol. 2005 Aug; 187(15):5189-94. PMID: 16030212; PMCID: PMC1196027.
      View in: PubMed, PubMed Central
    27. Oshiro N, Pajor A. Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1159-68. PMID: 15944208.
      View in: PubMed
    28. Pajor A, Randolph KM. Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter. J Biol Chem. 2005 May 13; 280(19):18728-35. PMID: 15774465; PMCID: PMC1224748.
      View in: PubMed, PubMed Central
    29. Buddington RK, Pajor A, Buddington KK, Pierzynowski S. Absorption of alpha-ketoglutarate by the gastrointestinal tract of pigs. Comp Biochem Physiol A Mol Integr Physiol. 2004 Jun; 138(2):215-20. PMID: 15275656.
      View in: PubMed
    30. Aruga S, Pajor A, Nakamura K, Liu L, Moe OW, Preisig PA, Alpern RJ. OKP cells express the Na-dicarboxylate cotransporter NaDC-1. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C64-72. PMID: 14973148.
      View in: PubMed
    31. Li H, Pajor A. Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. Am J Physiol Cell Physiol. 2003 Nov; 285(5):C1188-96. PMID: 12867358.
      View in: PubMed
    32. Li H, Pajor A. Serines 260 and 288 are involved in sulfate transport by hNaSi-1. J Biol Chem. 2003 Sep 26; 278(39):37204-12. PMID: 12857732.
      View in: PubMed
    33. Yao X, Pajor A. Arginine-349 and aspartate-373 of the Na(+)/dicarboxylate cotransporter are conformationally sensitive residues. Biochemistry. 2002 Jan 22; 41(3):1083-90. PMID: 11790133.
      View in: PubMed
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