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    Nissi Varki

    Address9500 Gilman Drive #0687
    CA La Jolla 92093
    Phone858-534-4933
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      Collapse Research 
      Collapse Research Activities and Funding
      Glycan Modulation of Inflammatory Responses
      NIH P01HL107150Jul 1, 2011 - May 31, 2018
      Role: Co-Investigator
      Genetic Modulation of Blood and Vascular Glycosylation
      NIH/NHLBI P01HL057345Sep 30, 1997 - Dec 31, 2013
      Role: Principal Investigator
      MECHANISMS OF METASTASIS OF HUMAN NEOPLASM
      NIH/NCI R01CA043716Jul 1, 1987 - Jun 30, 1991
      Role: Principal Investigator
      METASTASIS OF HUMAN LUNG ADENOCARCINOMA
      NIH/NCI R23CA043009Oct 1, 1985 - Dec 31, 1987
      Role: Principal Investigator
      INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
      NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
      Role: Co-Investigator
      METASTASIS OF HUMAN LUNG ADENOCARCINOMA
      NIH/NCI R23CA039982Jan 1, 1985 - Sep 30, 1985
      Role: Principal Investigator
      Specialized Cancer Center Support Grant
      NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Schwarz F, Landig CS, Siddiqui S, Secundino I, Olson J, Varki N, Nizet V, Varki A. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J. 2017 Jan 18. PMID: 28100677.
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      2. Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki N, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng GS. Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. Cell Rep. 2016 Dec 13; 17(11):2979-2993. PMID: 27974211.
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      3. Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A. Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E. J Biol Chem. 2017 Jan 20; 292(3):1029-1037. PMID: 27920204.
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      4. Hartmann P, Seebauer CT, Mazagova M, Horvath A, Wang L, Llorente C, Varki N, Brandl K, Ho SB, Schnabl B. Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity. Am J Physiol Gastrointest Liver Physiol. 2016 Mar 1; 310(5):G310-22. PMID: 26702135.
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      5. Fong JJ, Sreedhara K, Deng L, Varki N, Angata T, Liu Q, Nizet V, Varki A. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J. 2015 Nov 12; 34(22):2775-88. PMID: 26459514.
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      6. Varki N, Varki A. On the apparent rarity of epithelial cancers in captive chimpanzees. Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19; 370(1673). PMID: 26056369.
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      7. Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, Varki A, Gagneux P. Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife. 2015; 4. PMID: 25846707.
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      8. Pearce OM, Samraj AN, Läubli H, Varki N, Varki A. Reply to Mackenzie: A comparison of Neu5Gc and a-gal xenoantigens. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):E1405. PMID: 25713131.
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      9. Miyazaki M, Miyazaki K, Chen S, Chandra V, Wagatsuma K, Agata Y, Rodewald HR, Saito R, Chang AN, Varki N, Kawamoto H, Murre C. The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. Genes Dev. 2015 Feb 15; 29(4):409-25. PMID: 25691468.
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      10. Samraj AN, Pearce OM, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki N, Varki A. A red meat-derived glycan promotes inflammation and cancer progression. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):542-7. PMID: 25548184.
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      11. Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, Varki A. Host adaptation of a bacterial toxin from the human pathogen salmonella typhi. Cell. 2014 Dec 4; 159(6):1290-9. PMID: 25480294.
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      12. Läubli H, Alisson-Silva F, Stanczak MA, Siddiqui SS, Deng L, Verhagen A, Varki N, Varki A. Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a Tumor-associated Immunomodulatory Ligand for CD33-related Siglecs. J Biol Chem. 2014 Nov 28; 289(48):33481-91. PMID: 25320078.
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      13. Miyazaki M, Miyazaki K, Chen S, Itoi M, Miller M, Lu LF, Varki N, Chang AN, Broide DH, Murre C. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Nat Immunol. 2014 Aug; 15(8):767-76. PMID: 24973820.
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      14. Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med. 2014 Jun 2; 211(6):1231-42. PMID: 24799499.
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      15. Samraj AN, Läubli H, Varki N, Varki A. Corrigendum: involvement of a non-human sialic Acid in human cancer. Front Oncol. 2014; 4:83. PMID: 24795860.
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      16. Pearce OM, Läubli H, Verhagen A, Secrest P, Zhang J, Varki N, Crocker PR, Bui JD, Varki A. Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5998-6003. PMID: 24711415.
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      17. Samraj AN, Läubli H, Varki N, Varki A. Involvement of a non-human sialic Acid in human cancer. Front Oncol. 2014; 4:33. PMID: 24600589.
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      18. Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J. 2014 Mar; 28(3):1280-93. PMID: 24308974.
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      19. Cohen M, Zhang XQ, Senaati HP, Chen HW, Varki N, Schooley RT, Gagneux P. Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virol J. 2013; 10:321. PMID: 24261589.
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      20. Orr SL, Le D, Long JM, Sobieszczuk P, Ma B, Tian H, Fang X, Paulson JC, Marth JD, Varki N. A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar; 23(3):363-80. PMID: 23118208.
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      21. Cohen M, Varki N, Jankowski MD, Gagneux P. Using unfixed, frozen tissues to study natural mucin distribution. J Vis Exp. 2012; (67):e3928. PMID: 23023050.
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      22. Ma F, Wu D, Deng L, Secrest P, Zhao J, Varki N, Lindheim S, Gagneux P. Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. J Biol Chem. 2012 Nov 2; 287(45):38073-9. PMID: 22989879.
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      23. Banda K, Gregg CJ, Chow R, Varki N, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolylneuraminic acid. J Biol Chem. 2012 Aug 17; 287(34):28852-64. PMID: 22692204.
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      24. Wang X, Mitra N, Cruz P, Deng L. Evolution of siglec-11 and siglec-16 genes in hominins. Mol Biol Evol. 2012 Aug; 29(8):2073-86. PMID: 22383531.
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      25. Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki N, Wang H, Feng GS. Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell. 2011 May 17; 19(5):629-39. PMID: 21575863.
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      26. Mitra N, Banda K, Altheide TK, Schaffer L, Johnson-Pais TL, Beuten J, Leach RJ, Angata T, Varki N, Varki A. SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas. J Biol Chem. 2011 Jul 1; 286(26):23003-11. PMID: 21555517.
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      27. Varki N, Strobert E, Dick EJ, Benirschke K, Varki A. Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology. Annu Rev Pathol. 2011; 6:365-93. PMID: 21073341.
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      28. González-Navajas JM, Law J, Nguyen KP, Bhargava M, Corr MP, Varki N, Eckmann L, Hoffman HM, Lee J, Raz E. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010 Dec 20; 207(13):2799-807. PMID: 21115691.
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      29. Lee SH, Hu LL, Gonzalez-Navajas J, Seo GS, Shen C, Brick J, Herdman S, Varki N, Corr M, Lee J, Raz E. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med. 2010 Jun; 16(6):665-70. PMID: 20473309.
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      30. Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki N, Varki A. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 2009 Dec 10; 114(25):5225-35. PMID: 19828701.
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      31. Ye M, Hamzeh R, Geddis A, Varki N, Perryman MB, Grossfeld P. Deletion of JAM-C, a candidate gene for heart defects in Jacobsen syndrome, results in a normal cardiac phenotype in mice. Am J Med Genet A. 2009 Jul; 149A(7):1438-43. PMID: 19533782.
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      32. Löfling JC, Paton AW, Varki N, Paton JC, Varki A. A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome. Kidney Int. 2009 Jul; 76(2):140-4. PMID: 19387473.
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      33. Diaz SL, Padler-Karavani V, Ghaderi D, Hurtado-Ziola N, Yu H, Chen X, Brinkman-Van der Linden EC, Varki A, Varki N. Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. PLoS One. 2009; 4(1):e4241. PMID: 19156207.
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      34. Hedlund M, Padler-Karavani V, Varki N, Varki A. Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression. Proc Natl Acad Sci U S A. 2008 Dec 2; 105(48):18936-41. PMID: 19017806.
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      35. Turovskaya O, Foell D, Sinha P, Vogl T, Newlin R, Nayak J, Nguyen M, Olsson A, Nawroth PP, Bierhaus A, Varki N, Kronenberg M, Freeze HH, Srikrishna G. RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis. 2008 Oct; 29(10):2035-43. PMID: 18689872.
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      36. Padler-Karavani V, Yu H, Cao H, Chokhawala H, Karp F, Varki N, Chen X, Varki A. Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease. Glycobiology. 2008 Oct; 18(10):818-30. PMID: 18669916.
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      37. Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med. 2008 Jun; 14(6):648-55. PMID: 18488037.
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      38. Hedlund M, Ng E, Varki A, Varki N. alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo. Cancer Res. 2008 Jan 15; 68(2):388-94. PMID: 18199532.
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      39. Varki N, Varki A. Diversity in cell surface sialic acid presentations: implications for biology and disease. Lab Invest. 2007 Sep; 87(9):851-7. PMID: 17632542.
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      40. Brinkman-Van der Linden EC, Hurtado-Ziola N, Hayakawa T, Wiggleton L, Benirschke K, Varki A, Varki N. Human-specific expression of Siglec-6 in the placenta. Glycobiology. 2007 Sep; 17(9):922-31. PMID: 17580316.
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      41. Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT. Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection. Dis Aquat Organ. 2007 Jun 7; 76(1):17-26. PMID: 17718161.
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      42. Hedlund M, Tangvoranuntakul P, Takematsu H, Long JM, Housley GD, Kozutsumi Y, Suzuki A, Wynshaw-Boris A, Ryan AF, Gallo RL, Varki N, Varki A. N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution. Mol Cell Biol. 2007 Jun; 27(12):4340-6. PMID: 17420276.
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      43. Altheide TK, Hayakawa T, Mikkelsen TS, Diaz S, Varki N, Varki A. System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution. J Biol Chem. 2006 Sep 1; 281(35):25689-702. PMID: 16769723.
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      44. Holzer AK, Varki N, Le QT, Gibson MA, Naredi P, Howell SB. Expression of the human copper influx transporter 1 in normal and malignant human tissues. J Histochem Cytochem. 2006 Sep; 54(9):1041-9. PMID: 16709730.
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      45. Brown JR, Fuster MM, Li R, Varki N, Glass CA, Esko JD. A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination. Clin Cancer Res. 2006 May 1; 12(9):2894-901. PMID: 16675586.
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      46. Borges HL, Bird J, Wasson K, Cardiff RD, Varki N, Eckmann L, Wang JY. Tumor promotion by caspase-resistant retinoblastoma protein. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15587-92. PMID: 16227443.
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      47. Hayakawa T, Angata T, Lewis AL, Mikkelsen TS, Varki N, Varki A. A human-specific gene in microglia. Science. 2005 Sep 9; 309(5741):1693. PMID: 16151003.
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      48. McCole DF, Rogler G, Varki N, Barrett KE. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. Gastroenterology. 2005 Aug; 129(2):591-608. PMID: 16083715.
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      49. Datta V, Myskowski SM, Kwinn LA, Chiem DN, Varki N, Kansal RG, Kotb M, Nizet V. Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection. Mol Microbiol. 2005 May; 56(3):681-95. PMID: 15819624.
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      50. Gurantz D, Cowling RT, Varki N, Frikovsky E, Moore CD, Greenberg BH. IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart. J Mol Cell Cardiol. 2005 Mar; 38(3):505-15. PMID: 15733910.
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      51. Maaser C, Housley MP, Iimura M, Smith JR, Vallance BA, Finlay BB, Schreiber JR, Varki N, Kagnoff MF, Eckmann L. Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun. 2004 Jun; 72(6):3315-24. PMID: 15155635.
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      52. Hosaka T, Biggs WH, Tieu D, Boyer AD, Varki N, Cavenee WK, Arden KC. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci U S A. 2004 Mar 2; 101(9):2975-80. PMID: 14978268.
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      53. Henriksson KC, Almgren MA, Thurlow R, Varki N, Chang CL. A fluorescent orthotopic mouse model for reliable measurement and genetic modulation of human neuroblastoma metastasis. Clin Exp Metastasis. 2004; 21(6):563-70. PMID: 15679054.
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      54. Samimi G, Varki N, Wilczynski S, Safaei R, Alberts DS, Howell SB. Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients. Clin Cancer Res. 2003 Dec 1; 9(16 Pt 1):5853-9. PMID: 14676106.
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      55. Tangvoranuntakul P, Gagneux P, Diaz S, Bardor M, Varki N, Varki A, Muchmore E. Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12045-50. PMID: 14523234.
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      56. Gagneux P, Cheriyan M, Hurtado-Ziola N, van der Linden EC, Anderson D, McClure H, Varki A, Varki N. Human-specific regulation of alpha 2-6-linked sialic acids. J Biol Chem. 2003 Nov 28; 278(48):48245-50. PMID: 14500706.
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      57. Wahrenbrock M, Borsig L, Le D, Varki N, Varki A. Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. J Clin Invest. 2003 Sep; 112(6):853-62. PMID: 12975470.
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      58. Onami TM, Lin MY, Page DM, Reynolds SA, Katayama CD, Marth JD, Irimura T, Varki A, Varki N, Hedrick SM. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Mol Cell Biol. 2002 Jul; 22(14):5173-81. PMID: 12077344.
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      59. Martin LT, Marth JD, Varki A, Varki N. Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation. J Biol Chem. 2002 Sep 6; 277(36):32930-8. PMID: 12068010.
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      60. Angata T, Kerr SC, Greaves DR, Varki N, Crocker PR, Varki A. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. J Biol Chem. 2002 Jul 5; 277(27):24466-74. PMID: 11986327.
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      61. Borsig L, Wong R, Hynes RO, Varki N, Varki A. Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2193-8. PMID: 11854515.
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      62. Varki N, Varki A. Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans. Semin Thromb Hemost. 2002 Feb; 28(1):53-66. PMID: 11885026.
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      63. Hase K, Eckmann L, Leopard JD, Varki N, Kagnoff MF. Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium. Infect Immun. 2002 Feb; 70(2):953-63. PMID: 11796631.
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      64. Ozerdem U, Mach-Hofacre B, Varki N, Folberg R, Mueller AJ, Ochabski R, Pham T, Appelt K, Freeman WR. The effect of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinases, on uveal melanoma rabbit model. Curr Eye Res. 2002 Feb; 24(2):86-91. PMID: 12187478.
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