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Noninvasive therapy of brain cancer using a unique systemic delivery methodology with a cancer terminator virus. J Cell Physiol. 2024 Aug; 239(8):e31302.
Bhoopathi P, Mannangatti P, Pradhan AK, Kumar A, Maji S, Lang FF, Klibanov AL, Madan E, Cavenee WK, Keoprasert T, Sun D, Bjerkvig R, Thorsen F, Gogna R, Das SK, Emdad L, Fisher PB. PMID: 38775127.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma. Acta Neuropathol Commun. 2024 Mar 13; 12(1):40.
Harachi M, Masui K, Shimizu E, Murakami K, Onizuka H, Muragaki Y, Kawamata T, Nakayama H, Miyata M, Komori T, Cavenee WK, Mischel PS, Kurata A, Shibata N. PMID: 38481314; PMCID: PMC10935831.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis. Proc Natl Acad Sci U S A. 2023 Nov 07; 120(45):e2307094120.
Maji S, Pradhan AK, Kumar A, Bhoopathi P, Mannangatti P, Guo C, Windle JJ, Subler MA, Wang XY, Semmes OJ, Nyalwidhe JO, Mukhopadhyay N, Paul AK, Hatfield B, Levit MM, Madan E, Sarkar D, Emdad L, Cohen DJ, Gogna R, Cavenee WK, Das SK, Fisher PB. PMID: 37922327; PMCID: PMC10636346.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts. Elife. 2023 01 16; 12.
Lauer RC, Barry M, Smith TL, Thomas AM, Wu J, Du R, Lee JH, Rao A, Dobroff AS, Arap MA, Nunes DN, Silva IT, Dias-Neto E, Chen I, McCance DJ, Cavenee WK, Pasqualini R, Arap W. PMID: 36645410; PMCID: PMC9886275.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Somatic 9p24.1 alterations in HPV- head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity. Proc Natl Acad Sci U S A. 2022 11 22; 119(47):e2213835119.
Zhao X, Cohen EEW, William WN, Bianchi JJ, Abraham JP, Magee D, Spetzler DB, Gutkind JS, Alexandrov LB, Cavenee WK, Lippman SM, Davoli T. PMID: 36395141; PMCID: PMC9704728.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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The metabolomic landscape plays a critical role in glioma oncogenesis. Cancer Sci. 2022 May; 113(5):1555-1563.
Masui K, Cavenee WK, Mischel PS, Shibata N. PMID: 35271755; PMCID: PMC9128185.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein. Int J Mol Sci. 2021 Dec 22; 23(1).
Modi J, Roy A, Pradhan AK, Kumar A, Talukdar S, Bhoopathi P, Maji S, Mannangatti P, Sanchez De La Rosa D, Li J, Guo C, Subler MA, Windle JJ, Cavenee WK, Sarkar D, Wang XY, Das SK, Emdad L, Fisher PB. PMID: 35008495; PMCID: PMC8744595.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β. Proc Natl Acad Sci U S A. 2021 05 25; 118(21).
Pradhan AK, Maji S, Bhoopathi P, Talukdar S, Mannangatti P, Guo C, Wang XY, Cartagena LC, Idowu M, Landry JW, Sarkar D, Emdad L, Cavenee WK, Das SK, Fisher PB. PMID: 34016751; PMCID: PMC8166168.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Immune evasion in HPV- head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss. Proc Natl Acad Sci U S A. 2021 05 11; 118(19).
William WN, Zhao X, Bianchi JJ, Lin HY, Cheng P, Lee JJ, Carter H, Alexandrov LB, Abraham JP, Spetzler DB, Dubinett SM, Cleveland DW, Cavenee W, Davoli T, Lippman SM. PMID: 33952700; PMCID: PMC8126856.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer. Metabolites. 2021 Apr 01; 11(4).
Harachi M, Masui K, Cavenee WK, Mischel PS, Shibata N. PMID: 33916219; PMCID: PMC8066013.
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PubMed Mentions:
12
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A Mathematical Model to Estimate Chemotherapy Concentration at the Tumor-Site and Predict Therapy Response in Colorectal Cancer Patients with Liver Metastases. Cancers (Basel). 2021 Jan 25; 13(3).
Anaya DA, Dogra P, Wang Z, Haider M, Ehab J, Jeong DK, Ghayouri M, Lauwers GY, Thomas K, Kim R, Butner JD, Nizzero S, Ramírez JR, Plodinec M, Sidman RL, Cavenee WK, Pasqualini R, Arap W, Fleming JB, Cristini V. PMID: 33503971; PMCID: PMC7866038.
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PubMed Mentions:
6
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Tumour predisposition and cancer syndromes as models to study gene-environment interactions. Nat Rev Cancer. 2020 09; 20(9):533-549.
Carbone M, Arron ST, Beutler B, Bononi A, Cavenee W, Cleaver JE, Croce CM, D'Andrea A, Foulkes WD, Gaudino G, Groden JL, Henske EP, Hickson ID, Hwang PM, Kolodner RD, Mak TW, Malkin D, Monnat RJ, Novelli F, Pass HI, Petrini JH, Schmidt LS, Yang H. PMID: 32472073; PMCID: PMC8104546.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimals
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Lumefantrine, an antimalarial drug, reverses radiation and temozolomide resistance in glioblastoma. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12324-12331.
Rajesh Y, Biswas A, Kumar U, Banerjee I, Das S, Maji S, Das SK, Emdad L, Cavenee WK, Mandal M, Fisher PB. PMID: 32409605; PMCID: PMC7275698.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. Mol Cancer Res. 2020 08; 18(8):1142-1152.
Harachi M, Masui K, Honda H, Muragaki Y, Kawamata T, Cavenee WK, Mischel PS, Shibata N. PMID: 32366675.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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mTOR complex 2 is an integrator of cancer metabolism and epigenetics. Cancer Lett. 2020 05 28; 478:1-7.
Masui K, Harachi M, Cavenee WK, Mischel PS, Shibata N. PMID: 32145344.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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MDA-9/Syntenin (SDCBP): Novel gene and therapeutic target for cancer metastasis. Pharmacol Res. 2020 05; 155:104695.
Das SK, Maji S, Wechman SL, Bhoopathi P, Pradhan AK, Talukdar S, Sarkar D, Landry J, Guo C, Wang XY, Cavenee WK, Emdad L, Fisher PB. PMID: 32061839; PMCID: PMC7551653.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 Dec 09; 36(6):690-691.
Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 31821785; PMCID: PMC6946119.
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PubMed Mentions:
9 Fields:
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mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. J Biol Chem. 2019 12 20; 294(51):19740-19751.
Masui K, Harachi M, Ikegami S, Yang H, Onizuka H, Yong WH, Cloughesy TF, Muragaki Y, Kawamata T, Arai N, Komori T, Cavenee WK, Mischel PS, Shibata N. PMID: 31712311; PMCID: PMC6926466.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene. Genes (Basel). 2019 11 01; 10(11).
Berry JL, Polski A, Cavenee WK, Dryja TP, Murphree AL, Gallie BL. PMID: 31683923; PMCID: PMC6895859.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019 09 03; 30(3):525-538.e8.
Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. PMID: 31303424; PMCID: PMC6742496.
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PubMed Mentions:
77 Fields:
Translation:
HumansAnimalsCells
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Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies. Cancer Gene Ther. 2020 05; 27(5):301-310.
Staquicini FI, Smith TL, Tang FHF, Gelovani JG, Giordano RJ, Libutti SK, Sidman RL, Cavenee WK, Arap W, Pasqualini R. PMID: 31130731; PMCID: PMC6879804.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 May 13; 35(5):816.
Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 31085179; PMCID: PMC8717880.
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PubMed Mentions:
12 Fields:
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Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):10009-10018.
Orellana L, Thorne AH, Lema R, Gustavsson J, Parisian AD, Hospital A, Cordeiro TN, Bernadó P, Scott AM, Brun-Heath I, Lindahl E, Cavenee WK, Furnari FB, Orozco M. PMID: 31028138; PMCID: PMC6525488.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease: A Review. JAMA Neurol. 2019 04 01; 76(4):492-500.
Chohan MO, Marchiò S, Morrison LA, Sidman RL, Cavenee WK, Dejana E, Yonas H, Pasqualini R, Arap W. PMID: 30476961.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6308-6312.
Qu C, Wang Y, Wang P, Chen K, Wang M, Zeng H, Lu J, Song Q, Diplas BH, Tan D, Fan C, Guo Q, Zhu Z, Yin H, Jiang L, Chen X, Zhao H, He H, Wang Y, Li G, Bi X, Zhao X, Chen T, Tang H, Lv C, Wang D, Chen W, Zhou J, Zhao H, Cai J, Wang X, Wang S, Yan H, Zeng YX, Cavenee WK, Jiao Y. PMID: 30858324; PMCID: PMC6442629.
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PubMed Mentions:
78 Fields:
Translation:
HumansCells
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MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5687-5692.
Pradhan AK, Bhoopathi P, Talukdar S, Scheunemann D, Sarkar D, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 30842276; PMCID: PMC6431152.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 03 18; 35(3):504-518.e7.
Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 30827889; PMCID: PMC6424615.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Rethinking Glioblastoma Therapy: MDA-9/Syntenin Targeted Small Molecule. ACS Chem Neurosci. 2019 03 20; 10(3):1121-1123.
Das SK, Sarkar D, Cavenee WK, Emdad L, Fisher PB. PMID: 30681320.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk. Cancer Res. 2019 03 15; 79(6):1239-1251.
Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, Ljubimov VA, Shatalova ES, Wagner S, Li D, Mamelak AN, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Lyubimov AV, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY. PMID: 30659021; PMCID: PMC6625517.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Metabolic reprogramming in the pathogenesis of glioma: Update. Neuropathology. 2019 Feb; 39(1):3-13.
Masui K, Onizuka H, Cavenee WK, Mischel PS, Shibata N. PMID: 30609184.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death Differ. 2018 11; 25(11):1885-1904.
Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G. PMID: 30323273; PMCID: PMC6219489.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin. Autophagy. 2018; 14(10):1845-1846.
Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 30118375; PMCID: PMC6135626.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Reply to Yoshida: Delineating critical roles of MDA-9 in protective autophagy-mediated anoikis resistance in human glioma stem cells. Proc Natl Acad Sci U S A. 2018 08 14; 115(33):E7654-E7655.
Talukdar S, Das SK, Emdad L, Sarkar D, Cavenee WK, Fisher PB. PMID: 30087190; PMCID: PMC6099876.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Publisher Correction: PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2018 05 25; 9:16217.
Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB. PMID: 29799523; PMCID: PMC6026911.
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PubMed Mentions:
1 Fields:
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MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5768-5773.
Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 29760085; PMCID: PMC5984507.
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PubMed Mentions:
61 Fields:
Translation:
HumansCells
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Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts. J Vis Exp. 2018 04 26; (134).
Benitez JA, Zanca C, Ma J, Cavenee WK, Furnari FB. PMID: 29757276; PMCID: PMC6100979.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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FHL2 interacts with EGFR to promote glioblastoma growth. Oncogene. 2018 03; 37(10):1386-1398.
Sun L, Yu S, Xu H, Zheng Y, Lin J, Wu M, Wang J, Wang A, Lan Q, Furnari F, Cavenee W, Purow B, Li M. PMID: 29321665; PMCID: PMC8691187.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme. Nat Commun. 2017 12 04; 8(1):1913.
Newman JP, Wang GY, Arima K, Guan SP, Waters MR, Cavenee WK, Pan E, Aliwarga E, Chong ST, Kok CYL, Endaya BB, Habib AA, Horibe T, Ng WH, Ho IAW, Hui KM, Kordula T, Lam PYP. PMID: 29203859; PMCID: PMC5715073.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses. EMBO Mol Med. 2017 10; 9(10):1327-1330.
Teixeira AA, Marchiò S, Dias-Neto E, Nunes DN, da Silva IT, Chackerian B, Barry M, Lauer RC, Giordano RJ, Sidman RL, Wheeler CM, Cavenee WK, Pasqualini R, Arap W. PMID: 28751581; PMCID: PMC5623838.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE. Clin Cancer Res. 2018 02 15; 24(4):737-743.
Alexander BM, Ba S, Berger MS, Berry DA, Cavenee WK, Chang SM, Cloughesy TF, Jiang T, Khasraw M, Li W, Mittman R, Poste GH, Wen PY, Yung WKA, Barker AD, GBM AGILE Network. PMID: 28814435.
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PubMed Mentions:
90 Fields:
Translation:
Humans
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Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity. Genes Dev. 2017 06 15; 31(12):1212-1227.
Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee WK, Furnari FB. PMID: 28724615; PMCID: PMC5558924.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6812-6817.
Cai J, Lin Y, Zhang H, Liang J, Tan Y, Cavenee WK, Yan G. PMID: 28607091; PMCID: PMC5495246.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2017 05 12; 8:15223.
Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB. PMID: 28497778; PMCID: PMC5437297.
View in:
PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling. NPJ Precis Oncol. 2017; 1(1):1.
Liu F, Mischel PS, Cavenee WK. PMID: 29872691; PMCID: PMC5871882.
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PubMed Mentions:
2
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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125.
Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237; PMCID: PMC5334176.
View in:
PubMed Mentions:
332 Fields:
Translation:
HumansCells
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Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):370-375.
Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, Hu B, Emdad L, Valerie K, Sarkar D, Furnari FB, Cavenee WK, Wei J, Purves A, De SK, Pellecchia M, Fisher PB. PMID: 28011764; PMCID: PMC5240699.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme. J Control Release. 2016 12 28; 244(Pt A):14-23.
Chou ST, Patil R, Galstyan A, Gangalum PR, Cavenee WK, Furnari FB, Ljubimov VA, Chesnokova A, Kramerov AA, Ding H, Falahatian V, Mashouf L, Fox I, Black KL, Holler E, Ljubimov AV, Ljubimova JY. PMID: 27825958; PMCID: PMC5308909.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. 2016 Nov 14; 30(5):683-693.
Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. PMID: 27746144; PMCID: PMC5479636.
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PubMed Mentions:
162 Fields:
Translation:
HumansAnimalsCells
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mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling. Bioessays. 2016 09; 38(9):839-44.
Masui K, Shibata N, Cavenee WK, Mischel PS. PMID: 27427440; PMCID: PMC5501721.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Cancer metabolism as a central driving force of glioma pathogenesis. Brain Tumor Pathol. 2016 Jul; 33(3):161-8.
Masui K, Cavenee WK, Mischel PS. PMID: 27295313; PMCID: PMC5488809.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016 06; 131(6):803-20.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. PMID: 27157931.
View in:
PubMed Mentions:
6790 Fields:
Translation:
HumansAnimals
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Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma. Cancer Cell. 2016 Apr 11; 29(4):563-573.
Wei W, Shin YS, Xue M, Matsutani T, Masui K, Yang H, Ikegami S, Gu Y, Herrmann K, Johnson D, Ding X, Hwang K, Kim J, Zhou J, Su Y, Li X, Bonetti B, Chopra R, James CD, Cavenee WK, Cloughesy TF, Mischel PS, Heath JR, Gini B. PMID: 27070703; PMCID: PMC4831071.
View in:
PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment. Brain Pathol. 2015 Nov; 25(6):755-9.
Masui K, Cavenee WK, Mischel PS. PMID: 26526943; PMCID: PMC4636016.
View in:
PubMed Mentions:
19 Fields:
Translation:
Humans
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EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. Mol Cell. 2015 Oct 15; 60(2):307-18.
Liu F, Hon GC, Villa GR, Turner KM, Ikegami S, Yang H, Ye Z, Li B, Kuan S, Lee AY, Zanca C, Wei B, Lucey G, Jenkins D, Zhang W, Barr CL, Furnari FB, Cloughesy TF, Yong WH, Gahman TC, Shiau AK, Cavenee WK, Ren B, Mischel PS. PMID: 26455392; PMCID: PMC4609298.
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PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9406-11.
Masui K, Tanaka K, Ikegami S, Villa GR, Yang H, Yong WH, Cloughesy TF, Yamagata K, Arai N, Cavenee WK, Mischel PS. PMID: 26170313; PMCID: PMC4522814.
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PubMed Mentions:
70 Fields:
Translation:
HumansAnimalsCells
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PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8403-8.
Salameh A, Lee AK, Cardó-Vila M, Nunes DN, Efstathiou E, Staquicini FI, Dobroff AS, Marchiò S, Navone NM, Hosoya H, Lauer RC, Wen S, Salmeron CC, Hoang A, Newsham I, Lima LA, Carraro DM, Oliviero S, Kolonin MG, Sidman RL, Do KA, Troncoso P, Logothetis CJ, Brentani RR, Calin GA, Cavenee WK, Dias-Neto E, Pasqualini R, Arap W. PMID: 26080435; PMCID: PMC4500257.
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PubMed Mentions:
123 Fields:
Translation:
HumansAnimalsCells
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Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition. Oncotarget. 2015 May 20; 6(14):11751-67.
Shen Y, Li J, Nitta M, Futalan D, Steed T, Treiber JM, Taich Z, Stevens D, Wykosky J, Chen HZ, Carter BS, Becher OJ, Kennedy R, Esashi F, Sarkaria JN, Furnari FB, Cavenee WK, Desai A, Chen CC. PMID: 26059434; PMCID: PMC4494902.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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IGFBP2 potentiates nuclear EGFR-STAT3 signaling. Oncogene. 2016 Feb 11; 35(6):738-47.
Chua CY, Liu Y, Granberg KJ, Hu L, Haapasalo H, Annala MJ, Cogdell DE, Verploegen M, Moore LM, Fuller GN, Nykter M, Cavenee WK, Zhang W. PMID: 25893308; PMCID: PMC4615268.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma. Nat Rev Cancer. 2015 May; 15(5):302-10.
Furnari FB, Cloughesy TF, Cavenee WK, Mischel PS. PMID: 25855404; PMCID: PMC4875778.
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PubMed Mentions:
209 Fields:
Translation:
HumansCells
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Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1107-12.
Chen K, Yang D, Li X, Sun B, Song F, Cao W, Brat DJ, Gao Z, Li H, Liang H, Zhao Y, Zheng H, Li M, Buckner J, Patterson SD, Ye X, Reinhard C, Bhathena A, Joshi D, Mischel PS, Croce CM, Wang YM, Raghavakaimal S, Li H, Lu X, Pan Y, Chang H, Ba S, Luo L, Cavenee WK, Zhang W, Hao X. PMID: 25583476; PMCID: PMC4313862.
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PubMed Mentions:
89 Fields:
Translation:
Humans
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Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance. Cancer Biol Med. 2014 Dec; 11(4):255-63.
Wu SH, Bi JF, Cloughesy T, Cavenee WK, Mischel PS. PMID: 25610711; PMCID: PMC4296088.
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PubMed Mentions:
28 Fields:
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A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer Res. 2015 Jan 15; 75(2):394-404.
Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee WK, Furnari FB. PMID: 25432173; PMCID: PMC4297573.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. Oncogene. 2015 Jul 30; 34(31):4078-88.
Hu J, Muller KA, Furnari FB, Cavenee WK, VandenBerg SR, Gonias SL. PMID: 25347738; PMCID: PMC4411189.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3741-56.
Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY. PMID: 25061874; PMCID: PMC4151226.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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mTORC2 in the center of cancer metabolic reprogramming. Trends Endocrinol Metab. 2014 Jul; 25(7):364-73.
Masui K, Cavenee WK, Mischel PS. PMID: 24856037; PMCID: PMC4077930.
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PubMed Mentions:
74 Fields:
Translation:
HumansAnimalsCells
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Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. Oncogene. 2015 Mar 05; 34(10):1270-9.
Costa ET, Barnabé GF, Li M, Dias AA, Machado TR, Asprino PF, Cavalher FP, Ferreira EN, Del Mar Inda M, Nagai MH, Malnic B, Duarte ML, Leite KR, de Barros AC, Carraro DM, Chammas R, Armelin HA, Cavenee W, Furnari F, Camargo AA. PMID: 24662834.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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mTORC2 dictates Warburg effect and drug resistance. Cell Cycle. 2014; 13(7):1053-4.
Masui K, Cavenee WK, Mischel PS. PMID: 24583874; PMCID: PMC4013152.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. 2014 Feb 28; 5(4):882-93.
Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen CC. PMID: 24658464; PMCID: PMC4011590.
View in:
PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Efficient synthesis of chloro-derivatives of sialosyllactosylceramide, and their enhanced inhibitory effect on epidermal growth factor receptor activation. Oncol Lett. 2014 Apr; 7(4):933-940.
Kawashima N, Qu H, Lobaton M, Zhu Z, Sollogoub M, Cavenee WK, Handa K, Hakomori SI, Zhang Y. PMID: 24944646; PMCID: PMC3961331.
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PubMed Mentions:
1
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Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer Res. 2014 Mar 01; 74(5):1429-39.
Gomez GG, Volinia S, Croce CM, Zanca C, Li M, Emnett R, Gutmann DH, Brennan CW, Furnari FB, Cavenee WK. PMID: 24436148; PMCID: PMC3947420.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 2014 Jan 03; 343(6166):72-6.
Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. PMID: 24310612; PMCID: PMC4049335.
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PubMed Mentions:
307 Fields:
Translation:
HumansAnimalsCells
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Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks. Cancer Biol Med. 2013 Dec; 10(4):192-205.
Gomez GG, Wykosky J, Zanca C, Furnari FB, Cavenee WK. PMID: 24349829; PMCID: PMC3860350.
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PubMed Mentions:
24 Fields:
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mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab. 2013 Nov 05; 18(5):726-39.
Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, Campos C, Zhu S, Yang H, Yong WH, Cloughesy TF, Mellinghoff IK, Cavenee WK, Shaw RJ, Mischel PS. PMID: 24140020; PMCID: PMC3840163.
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PubMed Mentions:
238 Fields:
Translation:
HumansAnimalsCells
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The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15; 19(20):5722-32.
Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. PMID: 24030701; PMCID: PMC3815450.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Glioblastoma: from molecular pathology to targeted treatment. Annu Rev Pathol. 2014; 9:1-25.
Cloughesy TF, Cavenee WK, Mischel PS. PMID: 23937436.
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PubMed Mentions:
287 Fields:
Translation:
HumansAnimals
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EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180. Oncogene. 2014 May 08; 33(19):2504-12.
Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng SY. PMID: 23728337; PMCID: PMC3883905.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab. 2013 Jun 04; 17(6):1000-1008.
Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. PMID: 23707073; PMCID: PMC3679227.
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PubMed Mentions:
92 Fields:
Translation:
HumansAnimalsCells
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Arsenic reverses glioblastoma resistance to mTOR-targeted therapies. Cell Cycle. 2013 May 15; 12(10):1473-4.
Iwanami A, Cloughesy TF, Cavenee WK, Mischel PS. PMID: 23624839; PMCID: PMC3680520.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov. 2013 May; 3(5):534-47.
Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS. PMID: 23533263; PMCID: PMC3651754.
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A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments. Carcinogenesis. 2013 Apr; 34(4):725-38.
Masui K, Gini B, Wykosky J, Zanca C, Mischel PS, Furnari FB, Cavenee WK. PMID: 23455378; PMCID: PMC3616676.
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PubMed Mentions:
43 Fields:
Translation:
Humans
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PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4339-44.
Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, Dang J, Yang H, Zhu S, Kohyama J, Kitabayashi I, Cavenee WK, Cloughesy TF, Furnari FB, Nakamura M, Toyama Y, Okano H, Mischel PS. PMID: 23440206; PMCID: PMC3600508.
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A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS Genet. 2013; 9(2):e1003253.
Read RD, Fenton TR, Gomez GG, Wykosky J, Vandenberg SR, Babic I, Iwanami A, Yang H, Cavenee WK, Mischel PS, Furnari FB, Thomas JB. PMID: 23459592; PMCID: PMC3573097.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Genetic driver events in premalignancy: LOH validated for marking the risk of oral cancer. Cancer Prev Res (Phila). 2012 Sep; 5(9):1073-4.
Cavenee WK. PMID: 22911109.
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PubMed Mentions: Fields:
Translation:
Humans
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Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14164-9.
Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB. PMID: 22891331; PMCID: PMC3435194.
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PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
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Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter. Int J Cancer. 2013 Feb 01; 132(3):509-20.
Latha K, Li M, Chumbalkar V, Gururaj A, Hwang Y, Dakeng S, Sawaya R, Aldape K, Cavenee WK, Bogler O, Furnari FB. PMID: 22729867; PMCID: PMC3802533.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev. 2012 Apr 15; 26(8):756-84.
Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, Chin L, Hahn WC. PMID: 22508724; PMCID: PMC3337451.
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PubMed Mentions:
304 Fields:
Translation:
HumansCells
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Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance. Curr Cancer Drug Targets. 2012 Mar; 12(3):197-209.
Taylor TE, Furnari FB, Cavenee WK. PMID: 22268382; PMCID: PMC3464093.
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PubMed Mentions:
100 Fields:
Translation:
HumansAnimals
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Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3018-23.
Feng H, Hu B, Jarzynka MJ, Li Y, Keezer S, Johns TG, Tang CK, Hamilton RL, Vuori K, Nishikawa R, Sarkaria JN, Fenton T, Cheng T, Furnari FB, Cavenee WK, Cheng SY. PMID: 22323579; PMCID: PMC3286964.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma. J Exp Med. 2011 Dec 19; 208(13):2657-73.
Li M, Mukasa A, Inda MM, Zhang J, Chin L, Cavenee W, Furnari F. PMID: 22162832; PMCID: PMC3244036.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway. Oncogene. 2012 Sep 06; 31(36):4054-66.
Bonavia R, Inda MM, Vandenberg S, Cheng SY, Nagane M, Hadwiger P, Tan P, Sah DW, Cavenee WK, Furnari FB. PMID: 22139077; PMCID: PMC3537826.
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PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest. 2011 Dec; 121(12):4670-84.
Feng H, Hu B, Liu KW, Li Y, Lu X, Cheng T, Yiin JJ, Lu S, Keezer S, Fenton T, Furnari FB, Hamilton RL, Vuori K, Sarkaria JN, Nagane M, Nishikawa R, Cavenee WK, Cheng SY. PMID: 22080864; PMCID: PMC3223070.
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PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance. Cancer Discov. 2011 Nov; 1(6):524-38.
Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. PMID: 22145100; PMCID: PMC3229221.
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PubMed Mentions:
168 Fields:
Translation:
HumansCells
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Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15984-9.
Hu J, Jo M, Cavenee WK, Furnari F, VandenBerg SR, Gonias SL. PMID: 21896743; PMCID: PMC3179096.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism. J Cell Sci. 2011 Sep 01; 124(Pt 17):2938-50.
Cvrljevic AN, Akhavan D, Wu M, Martinello P, Furnari FB, Johnston AJ, Guo D, Pike L, Cavenee WK, Scott AM, Mischel PS, Hoogenraad NJ, Johns TG. PMID: 21878501; PMCID: PMC3706030.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. Mol Cancer Res. 2011 Aug; 9(8):1100-11.
Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T. PMID: 21693595; PMCID: PMC3157593.
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PubMed Mentions:
76 Fields:
Translation:
HumansCells
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Heterogeneity maintenance in glioblastoma: a social network. Cancer Res. 2011 Jun 15; 71(12):4055-60.
Bonavia R, Inda MM, Cavenee WK, Furnari FB. PMID: 21628493; PMCID: PMC3117065.
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PubMed Mentions:
249 Fields:
Translation:
HumansAnimalsCells
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Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR. J Proteome Res. 2011 Mar 04; 10(3):1343-52.
Chumbalkar V, Latha K, Hwang Y, Maywald R, Hawley L, Sawaya R, Diao L, Baggerly K, Cavenee WK, Furnari FB, Bogler O. PMID: 21214269; PMCID: PMC3049961.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations. Chin J Cancer. 2011 Jan; 30(1):5-12.
Wykosky J, Fenton T, Furnari F, Cavenee WK. PMID: 21192840; PMCID: PMC3359794.
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PubMed Mentions:
68 Fields:
Translation:
HumansCells
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Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. J Clin Invest. 2011 Jan; 121(1):161-73.
Staquicini FI, Ozawa MG, Moya CA, Driessen WH, Barbu EM, Nishimori H, Soghomonyan S, Flores LG, Liang X, Paolillo V, Alauddin MM, Basilion JP, Furnari FB, Bogler O, Lang FF, Aldape KD, Fuller GN, Höök M, Gelovani JG, Sidman RL, Cavenee WK, Pasqualini R, Arap W. PMID: 21183793; PMCID: PMC3007161.
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PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 2010 Aug 15; 24(16):1731-45.
Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, Depinho RA, Cavenee W, Furnari F. PMID: 20713517; PMCID: PMC2922502.
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PubMed Mentions:
275 Fields:
Translation:
HumansAnimalsCells
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KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment. J Natl Cancer Inst. 2010 Aug 04; 102(15):1131-47.
Huh SJ, Chen YL, Friedman SL, Liao J, Huang HJ, Cavenee WK, Robertson GP. PMID: 20660366; PMCID: PMC2914760.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One. 2010 May 24; 5(5):e10767.
Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MM, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, D'Andrea A, Chen CC. PMID: 20532243; PMCID: PMC2879424.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Escape from targeted inhibition: the dark side of kinase inhibitor therapy. Cell Cycle. 2010 May; 9(9):1661-2.
Wykosky J, Mukasa A, Furnari F, Cavenee WK. PMID: 20404502.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth. Mol Biosyst. 2010 Jul; 6(7):1227-37.
Huang PH, Miraldi ER, Xu AM, Kundukulam VA, Del Rosario AM, Flynn RA, Cavenee WK, Furnari FB, White FM. PMID: 20461251; PMCID: PMC3291333.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2616-21.
Mukasa A, Wykosky J, Ligon KL, Chin L, Cavenee WK, Furnari F. PMID: 20133782; PMCID: PMC2823874.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res. 2009 Sep 01; 69(17):6889-98.
Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, Dang J, Dinca EB, Plaisier SB, Oderberg I, Lee Y, Chen Z, Caldwell JS, Xie Y, Loo JA, Seligson D, Chakravari A, Lee FY, Weinmann R, Cloughesy TF, Nelson SF, Bergers G, Graeber T, Furnari FB, James CD, Cavenee WK, Johns TG, Mischel PS. PMID: 19690143; PMCID: PMC2770839.
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PubMed Mentions:
96 Fields:
Translation:
HumansAnimalsCells
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EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma. Cancer Res. 2009 May 15; 69(10):4252-9.
Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S. PMID: 19435898; PMCID: PMC2694953.
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PubMed Mentions:
133 Fields:
Translation:
HumansAnimalsCells
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Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5082-7.
Garrett TP, Burgess AW, Gan HK, Luwor RB, Cartwright G, Walker F, Orchard SG, Clayton AH, Nice EC, Rothacker J, Catimel B, Cavenee WK, Old LJ, Stockert E, Ritter G, Adams TE, Hoyne PA, Wittrup D, Chao G, Cochran JR, Luo C, Lou M, Huyton T, Xu Y, Fairlie WD, Yao S, Scott AM, Johns TG. PMID: 19289842; PMCID: PMC2656555.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Stem cells for treating glioblastoma: how close to reality? Neuro Oncol. 2009 Apr; 11(2):101.
James CD, Cavenee WK. PMID: 19237733; PMCID: PMC2718980.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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A drosophila model for EGFR-Ras and PI3K-dependent human glioma. PLoS Genet. 2009 Feb; 5(2):e1000374.
Read RD, Cavenee WK, Furnari FB, Thomas JB. PMID: 19214224; PMCID: PMC2636203.
View in:
PubMed Mentions:
114 Fields:
Translation:
HumansAnimalsCells
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Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell. 2008 Apr; 13(4):355-64.
Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L. PMID: 18394558; PMCID: PMC2292238.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor. Cell Cycle. 2008 Apr 01; 7(7):837-41.
Roeb W, Boyer A, Cavenee WK, Arden KC. PMID: 18414034.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clin Cancer Res. 2008 Jan 15; 14(2):488-93.
Yoshimoto K, Dang J, Zhu S, Nathanson D, Huang T, Dumont R, Seligson DB, Yong WH, Xiong Z, Rao N, Winther H, Chakravarti A, Bigner DD, Mellinghoff IK, Horvath S, Cavenee WK, Cloughesy TF, Mischel PS. PMID: 18223223.
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PubMed Mentions:
57 Fields:
Translation:
Humans
-
Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Res. 2008 Jan; 18(1):46-59.
Barrera LO, Li Z, Smith AD, Arden KC, Cavenee WK, Zhang MQ, Green RD, Ren B. PMID: 18042645; PMCID: PMC2134779.
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PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
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PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18085-90.
Roeb W, Boyer A, Cavenee WK, Arden KC. PMID: 17986608; PMCID: PMC2084300.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007 Nov 01; 21(21):2683-710.
Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. PMID: 17974913.
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PubMed Mentions:
1119 Fields:
Translation:
HumansAnimals
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Uncovering therapeutic targets for glioblastoma: a systems biology approach. Cell Cycle. 2007 Nov 15; 6(22):2750-4.
Huang PH, Cavenee WK, Furnari FB, White FM. PMID: 17986864.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12867-72.
Huang PH, Mukasa A, Bonavia R, Flynn RA, Brewer ZE, Cavenee WK, Furnari FB, White FM. PMID: 17646646; PMCID: PMC1937558.
View in:
PubMed Mentions:
194 Fields:
Translation:
HumansAnimalsCells
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The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007 Aug; 114(2):97-109.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P. PMID: 17618441; PMCID: PMC1929165.
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PubMed Mentions:
4933 Fields:
Translation:
Humans
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The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization. Clin Cancer Res. 2007 Mar 15; 13(6):1911-25.
Johns TG, Perera RM, Vernes SC, Vitali AA, Cao DX, Cavenee WK, Scott AM, Furnari FB. PMID: 17363548.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor-related apoptosis-inducing ligand. J Neurosurg. 2007 Mar; 106(3):407-16.
Nagane M, Cavenee WK, Shiokawa Y. PMID: 17367063.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas. J Clin Invest. 2007 Feb; 117(2):346-52.
Li D, Ji H, Zaghlul S, McNamara K, Liang MC, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Scott AM, Jungbluth AA, Cavenee WK, Old LJ, Demetri GD, Wong KK. PMID: 17256054; PMCID: PMC1770949.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Transgenic mice expressing PAX3-FKHR have multiple defects in muscle development, including ectopic skeletal myogenesis in the developing neural tube. Transgenic Res. 2006 Oct; 15(5):595-614.
Finckenstein FG, Davicioni E, Osborn KG, Cavenee WK, Arden KC, Anderson MJ. PMID: 16952014.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Res. 2006 Aug 15; 66(16):7864-9.
Wang MY, Lu KV, Zhu S, Dia EQ, Vivanco I, Shackleford GM, Cavenee WK, Mellinghoff IK, Cloughesy TF, Sawyers CL, Mischel PS. PMID: 16912159.
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PubMed Mentions:
128 Fields:
Translation:
HumansCells
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PCAF modulates PTEN activity. J Biol Chem. 2006 Sep 08; 281(36):26562-8.
Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB. PMID: 16829519.
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PubMed Mentions:
101 Fields:
Translation:
HumansAnimalsCells
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The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell. 2006 May; 9(5):379-90.
Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA. PMID: 16697958.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Identification of EGFRvIII-derived CTL epitopes restricted by HLA A0201 for dendritic cell based immunotherapy of gliomas. J Neurooncol. 2006 Jan; 76(1):23-30.
Wu AH, Xiao J, Anker L, Hall WA, Gregerson DS, Cavenee WK, Chen W, Low WC. PMID: 16155724.
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PubMed Mentions:
27 Fields:
Translation:
HumansCellsPHPublic Health
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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005 Nov 10; 353(19):2012-24.
Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN, Beroukhim R, Peck TC, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, Mischel PS. PMID: 16282176.
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PubMed Mentions:
596 Fields:
Translation:
HumansCells
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Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity. Clin Cancer Res. 2005 Sep 01; 11(17):6390-9.
Perera RM, Narita Y, Furnari FB, Gan HK, Murone C, Ahlkvist M, Luwor RB, Burgess AW, Stockert E, Jungbluth AA, Old LJ, Cavenee WK, Scott AM, Johns TG. PMID: 16144944.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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PTEN: a novel anti-oncogenic function independent of phosphatase activity. Cell Cycle. 2005 Apr; 4(4):540-2.
Okumura K, Zhao M, DePinho RA, Furnari FB, Cavenee WK. PMID: 15753657.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2703-6.
Okumura K, Zhao M, Depinho RA, Furnari FB, Cavenee WK. PMID: 15659546; PMCID: PMC549467.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimals
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Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther. 2005 Jan; 4(1):101-12.
Goudar RK, Shi Q, Hjelmeland MD, Keir ST, McLendon RE, Wikstrand CJ, Reese ED, Conrad CA, Traxler P, Lane HA, Reardon DA, Cavenee WK, Wang XF, Bigner DD, Friedman HS, Rich JN. PMID: 15657358.
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PubMed Mentions:
82 Fields:
Translation:
HumansAnimalsCells
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Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol. 2004 10; 24(20):8981-93.
Schmidt MHH, Hoeller D, Yu J, Furnari FB, Cavenee WK, Dikic I, Bögler O. PMID: 15456872; PMCID: PMC517880.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Methylation Profiling Identifies Epigenetic Markers for High-grade Gliomas. Cancer Genomics Proteomics. 2004 May-Jun; 1(3):209-214.
Waha A, Rodrigues FJ, Waha A, Meyer-Puttlitz B, Cavenee WK, Huang TH, Wiestler OD, Yan PS. PMID: 31394655.
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PubMed Mentions:
3 Fields:
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Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):2975-80.
Hosaka T, Biggs WH, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC. PMID: 14978268; PMCID: PMC365730.
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PubMed Mentions:
297 Fields:
Translation:
Animals
-
Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma. Brain Tumor Pathol. 2004; 21(2):53-6.
Nishikawa R, Sugiyama T, Narita Y, Furnari F, Cavenee WK, Matsutani M. PMID: 15700833.
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PubMed Mentions:
58 Fields:
Translation:
Humans
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The recessive nature of dominance. Genes Chromosomes Cancer. 2003 Dec; 38(4):322-5.
Cavenee WK. PMID: 14566850.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13418-23.
Brentani H, Caballero OL, Camargo AA, da Silva AM, da Silva WA, Dias Neto E, Grivet M, Gruber A, Guimaraes PE, Hide W, Iseli C, Jongeneel CV, Kelso J, Nagai MA, Ojopi EP, Osorio EC, Reis EM, Riggins GJ, Simpson AJ, de Souza S, Stevenson BJ, Strausberg RL, Tajara EH, Verjovski-Almeida S, Acencio ML, Bengtson MH, Bettoni F, Bodmer WF, Briones MR, Camargo LP, Cavenee W, Cerutti JM, Coelho Andrade LE, Costa dos Santos PC, Ramos Costa MC, da Silva IT, Estécio MR, Sa Ferreira K, Furnari FB, Faria M, Galante PA, Guimaraes GS, Holanda AJ, Kimura ET, Leerkes MR, Lu X, Maciel RM, Martins EA, Massirer KB, Melo AS, Mestriner CA, Miracca EC, Miranda LL, Nobrega FG, Oliveira PS, Paquola AC, Pandolfi JR, Campos Pardini MI, Passetti F, Quackenbush J, Schnabel B, Sogayar MC, Souza JE, Valentini SR, Zaiats AC, Amaral EJ, Arnaldi LA, de Araújo AG, de Bessa SA, Bicknell DC, Ribeiro de Camaro ME, Carraro DM, Carrer H, Carvalho AF, Colin C, Costa F, Curcio C, Guerreiro da Silva ID, Pereira da Silva N, Dellamano M, El-Dorry H, Espreafico EM, Scattone Ferreira AJ, Ayres Ferreira C, Fortes MA, Gama AH, Giannella-Neto D, Giannella ML, Giorgi RR, Goldman GH, Goldman MH, Hackel C, Ho PL, Kimura EM, Kowalski LP, Krieger JE, Leite LC, Lopes A, Luna AM, Mackay A, Mari SK, Marques AA, Martins WK, Montagnini A, Mourão Neto M, Nascimento AL, Neville AM, Nobrega MP, O'Hare MJ, Otsuka AY, Ruas de Melo AI, Paco-Larson ML, Guimarães Pereira G, Pereira da Silva N, Pesquero JB, Pessoa JG, Rahal P, Rainho CA, Rodrigues V, Rogatto SR, Romano CM, Romeiro JG, Rossi BM, Rusticci M, Guerra de Sá R, Sant' Anna SC, Sarmazo ML, Silva TC, Soares FA, Sonati Mde F, de Freitas Sousa J, Queiroz D, Valente V, Vettore AL, Villanova FE, Zago MA, Zalcberg H, Human Cancer Genome Project/Cancer Genome Anatomy Project Annotation Consortium, Human Cancer Genome Project Sequencing Consortium. PMID: 14593198; PMCID: PMC263829.
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PubMed Mentions:
44 Fields:
Translation:
Humans
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Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8904-9.
Hu B, Guo P, Fang Q, Tao HQ, Wang D, Nagane M, Huang HJ, Gunji Y, Nishikawa R, Alitalo K, Cavenee WK, Cheng SY. PMID: 12861074; PMCID: PMC166411.
View in:
PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8164-9.
Li Z, Van Calcar S, Qu C, Cavenee WK, Zhang MQ, Ren B. PMID: 12808131; PMCID: PMC166200.
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PubMed Mentions:
254 Fields:
Translation:
HumansCells
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Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. Proc Natl Acad Sci U S A. 2003 05 27; 100(11):6505-10.
Schmidt MHH, Furnari FB, Cavenee WK, Bögler O. PMID: 12734385; PMCID: PMC164476.
View in:
PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. Am J Pathol. 2003 Apr; 162(4):1083-93.
Guo P, Hu B, Gu W, Xu L, Wang D, Huang HJ, Cavenee WK, Cheng SY. PMID: 12651601; PMCID: PMC1851242.
View in:
PubMed Mentions:
126 Fields:
Translation:
HumansAnimalsCells
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Preparing for serendipity. Cancer Biol Ther. 2003 Mar-Apr; 2(2):213-5.
Cavenee WK. PMID: 12750567.
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PubMed Mentions: Fields:
Translation:
Humans
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A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):639-44.
Jungbluth AA, Stockert E, Huang HJ, Collins VP, Coplan K, Iversen K, Kolb D, Johns TJ, Scott AM, Gullick WJ, Ritter G, Cohen L, Scanlan MJ, Cavenee WK, Old LJ, Cavanee WK. PMID: 12515857; PMCID: PMC141049.
View in:
PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. Cancer Res. 2002 Nov 15; 62(22):6764-9.
Narita Y, Nagane M, Mishima K, Huang HJ, Furnari FB, Cavenee WK. PMID: 12438278.
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PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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Muscling in on rhabdomyosarcoma. Nat Med. 2002 Nov; 8(11):1200-1.
Cavenee WK. PMID: 12411939.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002 Oct; 32(2):245-53.
Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D. PMID: 12219087.
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PubMed Mentions:
238 Fields:
Translation:
Animals
-
A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. J Neurochem. 2002 May; 81(3):575-88.
De Smet C, Nishimori H, Furnari FB, Bögler O, Huang HJ, Cavenee WK. PMID: 12065666.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Genetics and new approaches to cancer therapy. Carcinogenesis. 2002 May; 23(5):683-6.
Cavenee WK. PMID: 12016138.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene. Int J Cancer. 2002 Mar 20; 98(3):398-408.
Johns TG, Stockert E, Ritter G, Jungbluth AA, Huang HJ, Cavenee WK, Smyth FE, Hall CM, Watson N, Nice EC, Gullick WJ, Old LJ, Burgess AW, Scott AM. PMID: 11920591.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol. 2002 Mar; 61(3):215-25; discussion 226-9.
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK. PMID: 11895036.
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PubMed Mentions:
574 Fields:
Translation:
Humans
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CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity. Brain Pathol. 2002 Jan; 12(1):12-20.
Steinbach JP, Supra P, Huang HJ, Cavenee WK, Weller M. PMID: 11770895; PMCID: PMC8095827.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Restriction landmark genome scanning. Methods Mol Biol. 2002; 200:53-70.
Costello JF, Plass C, Cavenee WK. PMID: 11951655.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor. J Biol Chem. 2001 Dec 07; 276(49):46313-8.
Klingler-Hoffmann M, Fodero-Tavoletti MT, Mishima K, Narita Y, Cavenee WK, Furnari FB, Huang HJ, Tiganis T. PMID: 11514572.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Vascular endothelial growth factor isoforms display distinct activities in promoting tumor angiogenesis at different anatomic sites. Cancer Res. 2001 Dec 01; 61(23):8569-77.
Guo P, Xu L, Pan S, Brekken RA, Yang ST, Whitaker GB, Nagane M, Thorpe PE, Rosenbaum JS, Su Huang HJ, Cavenee WK, Cheng SY. PMID: 11731444.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimals
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Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor. J Neurosurg. 2001 Sep; 95(3):472-9.
Nagane M, Narita Y, Mishima K, Levitzki A, Burgess AW, Cavenee WK, Huang HJ. PMID: 11565870.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9936-41.
Chuenkova MV, Furnari FB, Cavenee WK, Pereira MA. PMID: 11481434; PMCID: PMC55556.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR. Cancer Res. 2001 Jul 15; 61(14):5355-61.
Luwor RB, Johns TG, Murone C, Huang HJ, Cavenee WK, Ritter G, Old LJ, Burgess AW, Scott AM. PMID: 11454674.
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PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor. Cancer Res. 2001 Jul 15; 61(14):5349-54.
Mishima K, Johns TG, Luwor RB, Scott AM, Stockert E, Jungbluth AA, Ji XD, Suvarna P, Voland JR, Old LJ, Huang HJ, Cavenee WK. PMID: 11454673.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Malignant glioma: genetics and biology of a grave matter. Genes Dev. 2001 Jun 01; 15(11):1311-33.
Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. PMID: 11390353.
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PubMed Mentions:
468 Fields:
Translation:
HumansAnimals
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Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome. 2001 Jun; 12(6):416-25.
Biggs WH, Cavenee WK, Arden KC. PMID: 11353388.
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PubMed Mentions:
93 Fields:
Translation:
HumansAnimalsCells
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The potential of TRAIL for cancer chemotherapy. Apoptosis. 2001 Jun; 6(3):191-7.
Nagane M, Huang HJ, Cavenee WK. PMID: 11388668.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimals
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Non-isotopic silver-stained SSCP is more sensitive than automated direct sequencing for the detection of PTEN mutations in a mixture of DNA extracted from normal and tumor cells. Int J Oncol. 2001 May; 18(5):1023-6.
Fan X, Furnari FB, Cavenee WK, Castresana JS. PMID: 11295051.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1589-94.
Anderson MJ, Shelton GD, Cavenee WK, Arden KC. PMID: 11171995; PMCID: PMC29301.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications. Cancer Lett. 2001 Jan; 162 Suppl:S17-S21.
Nagane M, Lin H, Cavenee WK, Huang HJ. PMID: 11164186.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Is annexin 7 a tumor suppressor gene in prostate cancer? Pharmacogenomics J. 2001; 1(2):92-4.
Cardó-Vila M, Arden KC, Cavenee WK, Pasqualini R, Arap W. PMID: 11911446.
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PubMed Mentions: Fields:
Translation:
Humans
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A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8484-9.
Mishima K, Mazar AP, Gown A, Skelly M, Ji XD, Wang XD, Jones TR, Cavenee WK, Huang HJ. PMID: 10890917; PMCID: PMC26974.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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High-grade gliomas with chromosome 1p loss. J Neurosurg. 2000 Jun; 92(6):1080-1.
Cavenee WK. PMID: 10839286.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene. 2000 May 18; 19(22):2687-94.
Reiss K, Wang JY, Romano G, Furnari FB, Cavenee WK, Morrione A, Tu X, Baserga R. PMID: 10851068.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP. Genomics. 2000 Mar 01; 64(2):195-202.
Amler LC, Bauer A, Corvi R, Dihlmann S, Praml C, Cavenee WK, Schwab M, Hampton GM. PMID: 10729226.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer Res. 2000 Feb 15; 60(4):847-53.
Nagane M, Pan G, Weddle JJ, Dixit VM, Cavenee WK, Huang HJ. PMID: 10706092.
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PubMed Mentions:
98 Fields:
Translation:
HumansAnimalsCells
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Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet. 2000 Feb; 24(2):132-8.
Costello JF, Frühwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomäki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Su Huang H, Petrelli NJ, Zhang X, O'Dorisio MS, Held WA, Cavenee WK, Plass C. PMID: 10655057.
View in:
PubMed Mentions:
393 Fields:
Translation:
HumansCells
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SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes. Neuro Oncol. 2000 01; 2(1):6-15.
Bögler O, Furnari FB, Kindler-Roehrborn A, Sykes VW, Yung R, Huang HJ, Cavenee WK. PMID: 11302255; PMCID: PMC1920697.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Aberrant methylation of genes in low-grade astrocytomas. Brain Tumor Pathol. 2000; 17(2):49-56.
Costello JF, Plass C, Cavenee WK. PMID: 11210171.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Analysis of the p300/CBP-Associated Factor (PCAF) gene in astrocytic tumors. J Neurooncol. 2000; 46(1):17-22.
Nishimori H, Nishikawa R, Fujimaki T, Nakagomi T, Matsutani M, Huang HJ, Cavenee WK. PMID: 10896202.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. Cancer Res. 1999 Nov 01; 59(21):5608-14.
Valter MM, Hügel A, Huang HJ, Cavenee WK, Wiestler OD, Pietsch T, Wernert N. PMID: 10554042.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death. Oncogene. 1999 Sep 16; 18(37):5239-45.
Knudsen KE, Weber E, Arden KC, Cavenee WK, Feramisco JR, Knudsen ES. PMID: 10498874.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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The chromosome 10 monosomy common in human melanomas results from loss of two separate tumor suppressor loci. Cancer Res. 1999 Aug 01; 59(15):3596-601.
Robertson GP, Herbst RA, Nagane M, Huang HJ, Cavenee WK. PMID: 10446968.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. 1999 Jul 08; 18(27):3936-43.
Wick W, Furnari FB, Naumann U, Cavenee WK, Weller M. PMID: 10435616.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Identification and validation of tumor suppressor genes. Mol Cell Biol Res Commun. 1999 Jul; 2(1):1-10.
Robertson GP, Huang HJ, Cavenee WK. PMID: 10527883.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7421-6.
Biggs WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC. PMID: 10377430; PMCID: PMC22101.
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PubMed Mentions:
390 Fields:
Translation:
AnimalsCells
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A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels. Genomics. 1999 Jun 15; 58(3):254-62.
Smiraglia DJ, Frühwald MC, Costello JF, McCormick SP, Dai Z, Peltomäki P, O'Dorisio MS, Cavenee WK, Plass C. PMID: 10373323.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res. 1999 May 15; 59(10):2297-301.
Knudsen KE, Cavenee WK, Arden KC. PMID: 10344732.
View in:
PubMed Mentions:
70 Fields:
Translation:
HumansCells
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Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res. 1999 Apr 01; 59(7):1464-72.
Wang D, Huang HJ, Kazlauskas A, Cavenee WK. PMID: 10197615.
View in:
PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res. 1999 Feb 15; 59(4):798-802.
Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR. PMID: 10029065.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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Malignant transformation of p53-deficient astrocytes is modulated by environmental cues in vitro. Cell Growth Differ. 1999 Feb; 10(2):73-86.
Bögler O, Nagane M, Gillis J, Huang HJ, Cavenee WK. PMID: 10074901.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Causes of drug resistance and novel therapeutic opportunities for the treatment of glioblastoma. Drug Resist Updat. 1999 Feb; 2(1):30-37.
Nagane M, Huang HJ, Cavenee WK. PMID: 11504467.
View in:
PubMed Mentions:
1 Fields:
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The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res. 1998 Nov 15; 58(22):5002-8.
Furnari FB, Huang HJ, Cavenee WK. PMID: 9823298.
View in:
PubMed Mentions:
118 Fields:
Translation:
HumansCells
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Expression of vascular endothelial growth factor in human brain tumors. Acta Neuropathol. 1998 Nov; 96(5):453-62.
Nishikawa R, Cheng SY, Nagashima R, Huang HJ, Cavenee WK, Matsutani M. PMID: 9829808.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Host microvasculature influence on tumor vascular morphology and endothelial gene expression. Am J Pathol. 1998 Oct; 153(4):1239-48.
Roberts WG, Delaat J, Nagane M, Huang S, Cavenee WK, Palade GE. PMID: 9777955; PMCID: PMC1853053.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells. J Biol Chem. 1998 Aug 07; 273(32):20213-22.
Knudsen KE, Arden KC, Cavenee WK. PMID: 9685369.
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PubMed Mentions:
83 Fields:
Translation:
HumansCells
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In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9418-23.
Robertson GP, Furnari FB, Miele ME, Glendening MJ, Welch DR, Fountain JW, Lugo TG, Huang HJ, Cavenee WK. PMID: 9689095; PMCID: PMC21353.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. Cancer Res. 1998 Jul 01; 58(13):2724-6.
Carethers JM, Furnari FB, Zigman AF, Lavine JE, Jones MC, Graham GE, Teebi AS, Huang HJ, Ha HT, Chauhan DP, Chang CL, Cavenee WK, Boland CR. PMID: 9661881.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
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Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci U S A. 1998 May 12; 95(10):5724-9.
Nagane M, Levitzki A, Gazit A, Cavenee WK, Huang HJ. PMID: 9576951; PMCID: PMC20446.
View in:
PubMed Mentions:
117 Fields:
Translation:
HumansCells
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Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics. 1998 Jan 15; 47(2):187-99.
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC. PMID: 9479491.
View in:
PubMed Mentions:
113 Fields:
Translation:
HumansCells
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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12479-84.
Furnari FB, Lin H, Huang HS, Cavenee WK. PMID: 9356475; PMCID: PMC25009.
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PubMed Mentions:
144 Fields:
Translation:
HumansCells
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Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):12081-7.
Cheng SY, Nagane M, Huang HS, Cavenee WK. PMID: 9342366; PMCID: PMC23709.
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PubMed Mentions:
74 Fields:
Translation:
HumansCells
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Functional analysis of wild-type and malignant glioma derived CDKN2Abeta alleles: evidence for an RB-independent growth suppressive pathway. Oncogene. 1997 Oct 23; 15(17):2013-20.
Arap W, Knudsen E, Sewell DA, Sidransky D, Wang JY, Huang HJ, Cavenee WK. PMID: 9366518.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin for multifocal lesions. Cancer Res. 1997 Oct 01; 57(19):4171-6.
Larson AA, Liao SY, Stanbridge EJ, Cavenee WK, Hampton GM. PMID: 9331069.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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High resolution analysis of chromosome 3p alterations in cervical carcinoma. Cancer Res. 1997 Sep 15; 57(18):4082-90.
Larson AA, Kern S, Curtiss S, Gordon R, Cavenee WK, Hampton GM. PMID: 9307297.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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An arrayed human not I-EcoRV boundary library as a tool for RLGS spot analysis. DNA Res. 1997 Jun 30; 4(3):253-5.
Plass C, Weichenhan D, Catanese J, Costello JF, Yu F, Yu L, Smiraglia D, Cavenee WK, Caligiuri MA, deJong P, Held WA. PMID: 9330914.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Further evidence for ultraviolet light induction of CDKN2 (p16INK4) mutations in sporadic melanoma in vivo. J Invest Dermatol. 1997 Jun; 108(6):950.
Herbst RA, Gutzmer R, Matiaske F, Mommert S, Kapp A, Weiss J, Arden KC, Cavenee WK. PMID: 9182829.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Advances in the molecular genetics of gliomas. Curr Opin Oncol. 1997 May; 9(3):215-22.
Nagane M, Huang HJ, Cavenee WK. PMID: 9229142.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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The expression of RET and its multiple splice forms in developing human kidney. Oncogene. 1997 Apr 17; 14(15):1811-8.
Ivanchuk SM, Eng C, Cavenee WK, Mulligan LM. PMID: 9150387.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res. 1997 Apr 01; 57(7):1250-4.
Costello JF, Plass C, Arap W, Chapman VM, Held WA, Berger MS, Su Huang HJ, Cavenee WK. PMID: 9102208.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma. Oncogene. 1997 Feb 06; 14(5):603-9.
Arap W, Knudsen ES, Wang JY, Cavenee WK, Huang HJ. PMID: 9053859.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol. 1997 Feb; 93(2):109-17.
Pietsch T, Valter MM, Wolf HK, von Deimling A, Huang HJ, Cavenee WK, Wiestler OD. PMID: 9039457.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansCells
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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem. 1997 Jan 31; 272(5):2927-35.
Huang HS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD, Huang CM, Gill GN, Wiley HS, Cavenee WK. PMID: 9006938.
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PubMed Mentions:
236 Fields:
Translation:
HumansAnimalsCells
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Population variation at the polymorphic ApaLI restriction enzyme site in intron 5 of the WT1 gene. Clin Genet. 1996 Dec; 50(6):555-7.
Besnard-Guérin C, Winqvist R, Newsham I, Cavenee WK. PMID: 9147899.
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PubMed Mentions: Fields:
Translation:
Humans
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A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis. Cancer Res. 1996 Nov 01; 56(21):5079-86.
Nagane M, Coufal F, Lin H, Bögler O, Cavenee WK, Huang HJ. PMID: 8895767.
View in:
PubMed Mentions:
152 Fields:
Translation:
HumansAnimalsCells
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Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway. J Biol Chem. 1996 Oct 11; 271(41):25639-45.
Prigent SA, Nagane M, Lin H, Huvar I, Boss GR, Feramisco JR, Cavenee WK, Huang HS. PMID: 8810340.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res. 1996 Sep 01; 56(17):3859-61.
Han Y, Caday CG, Nanda A, Cavenee WK, Huang HJ. PMID: 8752145.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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cAMP effects on myogenic gene expression in rhabdomyosarcoma cells. Exp Cell Res. 1996 Aug 25; 227(1):55-62.
Wasserman LM, Newsham I, Huang HJ, Cavenee WK. PMID: 8806451.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8502-7.
Cheng SY, Huang HJ, Nagane M, Ji XD, Wang D, Shih CC, Arap W, Huang CM, Cavenee WK. PMID: 8710899; PMCID: PMC38701.
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PubMed Mentions:
75 Fields:
Translation:
HumansAnimalsCells
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Report of the Ninth International Symposium of the Foundation for Promotion of Cancer Research: basic and clinical research in brain tumors. Jpn J Clin Oncol. 1996 Aug; 26(4):277-82.
Black PM, Nomura K, Cavenee WK, Kakizoe T, Mukai K. PMID: 8765189.
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PubMed Mentions: Fields:
Translation:
Humans
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Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction. Genes Chromosomes Cancer. 1996 Aug; 16(4):254-60.
Arden KC, Anderson MJ, Finckenstein FG, Czekay S, Cavenee WK. PMID: 8875239.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: subregional mapping of chromosome 4 in cervical carcinoma. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6704-9.
Hampton GM, Larson AA, Baergen RN, Sommers RL, Kern S, Cavenee WK. PMID: 8692882; PMCID: PMC39090.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res. 1996 May 15; 56(10):2405-10.
Costello JF, Berger MS, Huang HS, Cavenee WK. PMID: 8625319.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansCells
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Analysis of replication error (RER+) phenotypes in cervical carcinoma. Cancer Res. 1996 Mar 15; 56(6):1426-31.
Larson AA, Kern S, Sommers RL, Yokota J, Cavenee WK, Hampton GM. PMID: 8640835.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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A common region of loss of heterozygosity in Wilms' tumor and embryonal rhabdomyosarcoma distal to the D11S988 locus on chromosome 11p15.5. Hum Genet. 1996 Feb; 97(2):163-70.
Besnard-Guérin C, Newsham I, Winqvist R, Cavenee WK. PMID: 8566947.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Molecular biology of malignant degeneration of astrocytoma. Pediatr Neurosurg. 1996; 24(1):41-9.
Furnari FB, Huang HJ, Cavenee WK. PMID: 8817614.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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The p53 gene and its role in human brain tumors. Glia. 1995 Nov; 15(3):308-27.
Bögler O, Huang HJ, Kleihues P, Cavenee WK. PMID: 8586466.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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EGFR gene amplification--rearrangement in human glioblastomas. Int J Cancer. 1995 Jul 17; 62(2):145-8.
Schwechheimer K, Huang S, Cavenee WK. PMID: 7622287.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Definition and refinement of chromosome 11 regions of loss of heterozygosity in breast cancer: identification of a new region at 11q23.3. Cancer Res. 1995 Jul 15; 55(14):3003-7.
Negrini M, Rasio D, Hampton GM, Sabbioni S, Rattan S, Carter SL, Rosenberg AL, Schwartz GF, Shiloh Y, Cavenee WK, et al. PMID: 7606718.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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The t(11;22)(p15.5;q11.23) in a retroperitoneal rhabdoid tumor also includes a regional deletion distal to CRYBB2 on 22q. Genes Chromosomes Cancer. 1995 Jul; 13(3):145-50.
Besnard-Guérin C, Cavenee W, Newsham I. PMID: 7669732.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Loss of wild-type p53 bestows a growth advantage on primary cortical astrocytes and facilitates their in vitro transformation. Cancer Res. 1995 Jul 01; 55(13):2746-51.
Bögler O, Huang HJ, Cavenee WK. PMID: 7796398.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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A defined region of loss of heterozygosity at 11q23 in cutaneous malignant melanoma. Cancer Res. 1995 Jun 15; 55(12):2494-6.
Herbst RA, Larson A, Weiss J, Cavenee WK, Hampton GM, Arden KC. PMID: 7780954.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med. 1995 Jun; 1(6):570-7.
Wales MM, Biel MA, el Deiry W, Nelkin BD, Issa JP, Cavenee WK, Kuerbitz SJ, Baylin SB. PMID: 7585125.
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PubMed Mentions:
124 Fields:
Translation:
HumansCells
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Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res. 1995 May 01; 55(9):1941-5.
Nishikawa R, Furnari FB, Lin H, Arap W, Berger MS, Cavenee WK, Su Huang HJ. PMID: 7728764.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res. 1995 Mar 15; 55(6):1351-4.
Arap W, Nishikawa R, Furnari FB, Cavenee WK, Huang HJ. PMID: 7882335.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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The genetic basis of cancer. Sci Am. 1995 Mar; 272(3):72-9.
Cavenee WK, White RL. PMID: 7871410.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):1008-12.
Van Meir EG, Roemer K, Diserens AC, Kikuchi T, Rempel SA, Haas M, Huang HJ, Friedmann T, de Tribolet N, Cavenee WK. PMID: 7862624; PMCID: PMC42626.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Genetics and cancer: a second look. Introduction. Cancer Surv. 1995; 25:1-2.
Solomon E, Ponder BA, Cavenee WK. PMID: 8718509.
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PubMed Mentions: Fields:
Translation:
Humans
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Genetics and malignant progression of human brain tumours. Cancer Surv. 1995; 25:233-75.
Furnari FB, Huang HJ, Cavenee WK. PMID: 8718522.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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A constitutional BWS-related t(11;16) chromosome translocation occurring in the same region of chromosome 16 implicated in Wilms' tumors. Genes Chromosomes Cancer. 1995 Jan; 12(1):1-7.
Newsham I, Kindler-Röhrborn A, Daub D, Cavenee W. PMID: 7534105.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Dinucleotide repeat polymorphism adjacent to CDKN2. Hum Mol Genet. 1994 Dec; 3(12):2265.
Herbst RA, Nobori T, Cavenee WK, Carson DA, Arden KC. PMID: 7881438.
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PubMed Mentions: Fields:
Translation:
HumansCells
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p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res. 1994 Nov 01; 54(21):5649-51.
Adesina AM, Nalbantoglu J, Cavenee WK. PMID: 7923211.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat Genet. 1994 Oct; 8(2):171-6.
Van Meir EG, Polverini PJ, Chazin VR, Su Huang HJ, de Tribolet N, Cavenee WK. PMID: 7531056.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Loss of heterozygosity in sporadic human breast carcinoma: a common region between 11q22 and 11q23.3. Cancer Res. 1994 Sep 01; 54(17):4586-9.
Hampton GM, Mannermaa A, Winqvist R, Alavaikko M, Blanco G, Taskinen PJ, Kiviniemi H, Newsham I, Cavenee WK, Evans GA, Winquist R. PMID: 8062246.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7727-31.
Nishikawa R, Ji XD, Harmon RC, Lazar CS, Gill GN, Cavenee WK, Huang HJ. PMID: 8052651; PMCID: PMC44475.
View in:
PubMed Mentions:
351 Fields:
Translation:
HumansAnimalsCells
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Loss of heterozygosity for 10q22-10qter in malignant melanoma progression. Cancer Res. 1994 Jun 15; 54(12):3111-4.
Herbst RA, Weiss J, Ehnis A, Cavenee WK, Arden KC. PMID: 8205526.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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A new highly polymorphic DNA restriction site marker in the 5' region of the human tyrosine hydroxylase gene (TH) detecting loss of heterozygosity in human embryonal rhabdomyosarcoma. Hum Genet. 1994 Mar; 93(3):349-50.
Besnard-Guérin C, Cavenee WK, Newsham I. PMID: 7510263.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Molecular sublocalization and characterization of the 11;22 translocation breakpoint in a malignant rhabdoid tumor. Genomics. 1994 Feb; 19(3):433-40.
Newsham I, Daub D, Besnard-Guerin C, Cavenee W. PMID: 8188285.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res. 1994 Feb 01; 54(3):649-52.
Van Meir EG, Kikuchi T, Tada M, Li H, Diserens AC, Wojcik BE, Huang HJ, Friedmann T, de Tribolet N, Cavenee WK. PMID: 8306326.
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PubMed Mentions:
106 Fields:
Translation:
HumansAnimalsCells
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The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35. Cytogenet Cell Genet. 1994; 66(1):18-21.
Weiss J, Rubinfeld B, Polakis PG, McCormick F, Cavenee WK, Arden KC. PMID: 8275700.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Point mutations and allelic loss in the TP53 locus of cutaneous malignant melanomas. Arch Dermatol Res. 1994; 286(7):417-9.
Weiss J, Cavenee WK, Herbst RA, Jung EG, Arden KC. PMID: 7818283.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Refinement of regional loss of heterozygosity for chromosome 11p15.5 in human breast tumors. Cancer Res. 1993 Oct 01; 53(19):4486-8.
Winqvist R, Mannermaa A, Alavaikko M, Blanco G, Taskinen PJ, Kiviniemi H, Newsham I, Cavenee W. PMID: 8402619.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10. Hum Genet. 1993 Sep; 92(2):169-74.
Karlbom AE, James CD, Boethius J, Cavenee WK, Collins VP, Nordenskjöld M, Larsson C. PMID: 8370584.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome. Genes Chromosomes Cancer. 1993 Jul; 7(3):131-6.
Gessler M, König A, Moore J, Qualman S, Arden K, Cavenee W, Bruns G. PMID: 7687865.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Mutation and expression of the p53 gene in malignant melanoma cell lines. Int J Cancer. 1993 Jun 19; 54(4):693-9.
Weiss J, Schwechheimer K, Cavenee WK, Herlyn M, Arden KC. PMID: 8514460.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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DNA hypermethylation is associated with 17p allelic loss in neural tumors. Cancer Res. 1993 Jun 15; 53(12):2715-8.
Makos M, Nelkin BD, Chazin VR, Cavenee WK, Brodeur GM, Baylin SB. PMID: 8389241.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Genetics of cancer predisposition and progression. Clin Investig. 1993 Jun; 71(6):488-502.
Schwechheimer K, Cavenee WK. PMID: 8353410.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningioma progression. Cancer Res. 1993 May 15; 53(10 Suppl):2386-92.
Rempel SA, Schwechheimer K, Davis RL, Cavenee WK, Rosenblum ML. PMID: 8485725.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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A genetic linkage map with 29 loci spanning human chromosome 13q. Genomics. 1993 May; 16(2):515-9.
Gerken S, Leppert M, O'Connell P, Cavenee W, James CD, Ballard L, Stauffer D, Elsner T, Plaetke R, Lalouel JM, et al. PMID: 8100218.
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Translation:
HumansCells
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Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene. Cancer Res. 1993 Mar 01; 53(5):957-61.
Kikuchi T, Rempel SA, Rutz HP, de Tribolet N, Mulligan L, Cavenee WK, Jothy S, Leduy L, Van Meir EG. PMID: 8439970.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Tumors and developmental anomalies associated with Wilms tumor. Med Pediatr Oncol. 1993; 21(3):199-204.
Newsham I, Cavenee W. PMID: 8383280.
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Translation:
Humans
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Characterization of polymorphic and monomorphic loci for chromosome 11p15.5. Mamm Genome. 1993; 4(8):451-3.
Newsham I, Artigas C, Lasko D, Cavenee W. PMID: 8104058.
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HumansCells
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A siren song from tumor cells. J Clin Invest. 1993 Jan; 91(1):3.
Cavenee WK. PMID: 7678605; PMCID: PMC329986.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Retinoblastoma and p53 gene product expression in breast carcinoma: immunohistochemical analysis and clinicopathologic correlation. Hum Pathol. 1992 Dec; 23(12):1388-94.
Trudel M, Mulligan L, Cavenee W, Margolese R, Côté J, Gariépy G. PMID: 1468776.
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PubMed Mentions:
19 Fields:
Translation:
Humans
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Gliomas in families. Can J Neurol Sci. 1992 Nov; 19(4):492-7.
Ikizler Y, van Meyel DJ, Ramsay DA, Abdallah GL, Allaster RM, Macdonald DR, Cavenee WK, Cairncross JG. PMID: 1423046.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Accumulation of genetic defects during astrocytoma progression. Cancer. 1992 Sep 15; 70(6 Suppl):1788-93.
Cavenee WK. PMID: 1325281.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. Cancer Res. 1992 Apr 01; 52(7):1780-5.
Fong CT, White PS, Peterson K, Sapienza C, Cavenee WK, Kern SE, Vogelstein B, Cantor AB, Look AT, Brodeur GM. PMID: 1551108.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1755-9.
Loh WE, Scrable HJ, Livanos E, Arboleda MJ, Cavenee WK, Oshimura M, Weissman BE. PMID: 1347425; PMCID: PMC48531.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Developmental genetics and childhood cancer. AACR special conference in cancer research. Cancer Res. 1991 Oct 01; 51(19):5435-9.
Knudson A, Vande Woude GF, Friend SH, Cavenee WK, Brodeur GM. PMID: 1655251.
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PubMed Mentions: Fields:
Translation:
Humans
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Muscle-specific gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development. Cancer Res. 1991 Oct 01; 51(19):5100-6.
Tonin PN, Scrable H, Shimada H, Cavenee WK. PMID: 1717137.
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PubMed Mentions:
48 Fields:
Translation:
HumansCells
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Charles S. Mott Prize. Recessive mutations in the causation of human cancer. Cancer. 1991 May 15; 67(10):2431-5.
Cavenee WK. PMID: 2015543.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Genetics of the malignant progression of astrocytoma. J Cell Biochem. 1991 May; 46(1):3-8.
Mikkelsen T, Cairncross JG, Cavenee WK. PMID: 1874797.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 1991 Apr 15; 51(8):2164-72.
Ekstrand AJ, James CD, Cavenee WK, Seliger B, Pettersson RF, Collins VP. PMID: 2009534.
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PubMed Mentions:
193 Fields:
Translation:
Humans
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Molecular genetics of human cancer predisposition and progression. Mutat Res. 1991 Apr; 247(2):199-202.
Cavenee WK, Scrable HJ, James CD. PMID: 2011137.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors. Cancer Res. 1991 Mar 15; 51(6):1684-8.
James CD, He J, Carlbom E, Nordenskjold M, Cavenee WK, Collins VP. PMID: 1998958.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Microdissection of chromosome band 11p15.5: characterization of probes mapping distal to the HBBC locus. Genes Chromosomes Cancer. 1991 Mar; 3(2):108-16.
Newsham I, Claussen U, Lüdecke HJ, Mason M, Senger G, Horsthemke B, Cavenee W. PMID: 1676905.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15. Am J Hum Genet. 1991 Mar; 48(3):525-35.
Phaneuf D, Labelle Y, Bérubé D, Arden K, Cavenee W, Gagné R, Tanguay RM. PMID: 1998338; PMCID: PMC1682993.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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A polymorphism of D13S86 from the region 13q14.1 to 13q22. Nucleic Acids Res. 1991 Feb 11; 19(3):684.
McHaffie NP, Houwen R, Cavenee W, Cox DW. PMID: 1672759; PMCID: PMC333677.
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Translation:
HumansCells
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Recessive mutations in cancer predisposition and progression. Basic Life Sci. 1991; 57:171-80; discussion 180-1.
Cavenee WK. PMID: 1667571.
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Translation:
HumansCells
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Genetics and cancer. Eur J Cancer. 1991; 27(12):1706-7.
Cavenee WK, Ponder B, Solomon E. PMID: 1782088.
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Translation:
Humans
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Isolation and regional localization of 25 anonymous DNA probes on a chromosome 13 hybrid panel. Cytogenet Cell Genet. 1991; 57(2-3):87-90.
Houwen RH, Pautler SE, Barwell JA, Arden K, Buchanan JA, James CD, Cavenee WK, Buys CH, Cowell JK, Cox DW. PMID: 1914527.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Loss of constitutional heterozygosity in human cancer. Annu Rev Genet. 1991; 25:281-314.
Lasko D, Cavenee W, Nordenskjöld M. PMID: 1687498.
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PubMed Mentions:
83 Fields:
Translation:
Humans
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Structural alterations at the putative retinoblastoma locus in some human leukemias and preleukemia. Cancer Genet Cytogenet. 1990 Oct 01; 49(1):15-23.
Hansen MF, Morgan R, Sandberg AA, Cavenee WK. PMID: 2397469.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Molecular genetics in the pathology and diagnosis of retinoblastoma. Brain Pathol. 1990 Sep; 1(1):25-32.
Gennett IN, Cavenee WK. PMID: 1669690.
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Translation:
HumansCells
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Mechanisms of p53 loss in human sarcomas. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5863-7.
Mulligan LM, Matlashewski GJ, Scrable HJ, Cavenee WK. PMID: 2143022; PMCID: PMC54429.
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PubMed Mentions:
70 Fields:
Translation:
HumansAnimalsCells
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Loss of genetic information in central nervous system tumors common to children and young adults. Genes Chromosomes Cancer. 1990 Jul; 2(2):94-102.
James CD, He J, Carlbom E, Mikkelsen T, Ridderheim PA, Cavenee WK, Collins VP. PMID: 1980610.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Suppressors of the malignant phenotype. Cell Growth Differ. 1990 Apr; 1(4):201-7.
Mikkelsen T, Cavenee WK. PMID: 2128032.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2182-6.
Scrable HJ, Johnson DK, Rinchik EM, Cavenee WK. PMID: 2315312; PMCID: PMC53650.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature. 1990 Feb 22; 343(6260):774-8.
Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GA. PMID: 2154702.
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PubMed Mentions:
296 Fields:
Translation:
HumansCells
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Molecular genetic aspects of glial tumour evolution. Cancer Surv. 1990; 9(4):631-44.
James CD, Mikkelsen T, Cavenee WK, Collins VP. PMID: 1983210.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5. Cytogenet Cell Genet. 1990; 53(2-3):161-5.
Arden KC, Boutin JM, Djiane J, Kelly PA, Cavenee WK. PMID: 2369845.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression. Adv Cancer Res. 1990; 54:25-62.
Scrable HJ, Sapienza C, Cavenee WK. PMID: 2404380.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7480-4.
Scrable H, Cavenee W, Ghavimi F, Lovell M, Morgan K, Sapienza C. PMID: 2798419; PMCID: PMC298088.
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PubMed Mentions:
72 Fields:
Translation:
HumansCells
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Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma. Cancer Res. 1989 Sep 15; 49(18):5130-5.
Mori N, Yokota J, Oshimura M, Cavenee WK, Mizoguchi H, Noguchi M, Shimosato Y, Sugimura T, Terada M. PMID: 2569931.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Molecular differential pathology of rhabdomyosarcoma. Genes Chromosomes Cancer. 1989 Sep; 1(1):23-35.
Scrable H, Witte D, Shimada H, Seemayer T, Sheng WW, Soukup S, Koufos A, Houghton P, Lampkin B, Cavenee W. PMID: 2487144.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Loss of heterozygosity in stages of malignancy. Clin Chem. 1989 Jul; 35(7 Suppl):B48-52.
Cavenee WK. PMID: 2663235.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5. Am J Hum Genet. 1989 May; 44(5):711-9.
Koufos A, Grundy P, Morgan K, Aleck KA, Hadro T, Lampkin BC, Kalbakji A, Cavenee WK. PMID: 2539717; PMCID: PMC1715635.
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PubMed Mentions:
86 Fields:
Translation:
HumansCells
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Molecular mechanisms of oncogenesis. Lab Invest. 1989 May; 60(5):585-99.
Seemayer TA, Cavenee WK. PMID: 2654471.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Mitotic recombination of chromosome 17 in astrocytomas. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2858-62.
James CD, Carlbom E, Nordenskjold M, Collins VP, Cavenee WK. PMID: 2565039; PMCID: PMC287018.
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PubMed Mentions:
71 Fields:
Translation:
HumansCells
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Molecular detection of chromosomal translocations that disrupt the putative retinoblastoma susceptibility locus. Mol Cell Biol. 1989 Jan; 9(1):1-5.
Higgins MJ, Hansen MF, Cavenee WK, Lalande M. PMID: 2927388; PMCID: PMC362138.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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The chromosome 11 region flanking the t(11;14) breakpoint in human T-ALL is deleted in Wilms' tumor hybrids. Oncogene Res. 1989; 5(2):143-8.
Finver SN, Martiniere C, Kagan J, Cavenee W, Croce CM. PMID: 2558334.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Loss of genetic information in cancer. Ciba Found Symp. 1989; 142:79-88; discussion 88-92.
Cavenee WK, Hansen MF, Scrable HJ, James CD. PMID: 2743836.
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PubMed Mentions: Fields:
Translation:
Humans
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Tumor progression stage: specific losses of heterozygosity. Princess Takamatsu Symp. 1989; 20:33-42.
Cavenee WK. PMID: 2488236.
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Translation:
Humans
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Mitotic abnormalities leading to cancer predisposition and progression. Cancer Detect Prev. 1989; 14(2):269-73.
Cavenee WK. PMID: 2559800.
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Translation:
Humans
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Current knowledge of heritable tumors. Birth Defects Orig Artic Ser. 1989; 25(2):29-43.
Cavenee WK. PMID: 2655740.
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PubMed Mentions: Fields:
Translation:
Humans
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Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11. Nature. 1988 Nov 24; 336(6197):374-6.
Grundy P, Koufos A, Morgan K, Li FP, Meadows AT, Cavenee WK. PMID: 2848199.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Clonal genomic alterations in glioma malignancy stages. Cancer Res. 1988 Oct 01; 48(19):5546-51.
James CD, Carlbom E, Dumanski JP, Hansen M, Nordenskjold M, Collins VP, Cavenee WK. PMID: 2901288.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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Retinoblastoma and the progression of tumor genetics. Trends Genet. 1988 May; 4(5):125-8.
Hansen MF, Cavenee WK. PMID: 3070862.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Tumor suppressors: recessive mutations that lead to cancer. Cell. 1988 Apr 22; 53(2):173-4.
Hansen MF, Cavenee WK. PMID: 3282673.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
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A polymorphic DNA marker on chromosome 10 linked to RBP3 on the MEN2A side. Cytogenet Cell Genet. 1988; 48(4):246-7.
Wu J, Cavenee WK, Miki T, Kidd KK. PMID: 2907872.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Genetics and the etiology of solid tumors. Important Adv Oncol. 1988; 83-101.
Nordenskjold M, Cavenee WK. PMID: 3042611.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Genetics of cancer predisposition. Cancer Res. 1987 Nov 01; 47(21):5518-27.
Hansen MF, Cavenee WK. PMID: 2889524.
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PubMed Mentions:
35 Fields:
Translation:
Humans
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Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping. Nature. 1987 Oct 15-21; 329(6140):645-7.
Scrable HJ, Witte DP, Lampkin BC, Cavenee WK. PMID: 3657988.
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PubMed Mentions:
83 Fields:
Translation:
Humans
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Genetic markers for assessment of retinoblastoma predisposition. Dis Markers. 1987 Sep; 5(3):141-52.
Buchanan JA, Cavenee WK. PMID: 3332257.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene. DNA. 1987 Aug; 6(4):283-95.
Gray A, Tam AW, Dull TJ, Hayflick J, Pintar J, Cavenee WK, Koufos A, Ullrich A. PMID: 3652904.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Retinoblastoma and osteosarcoma: the prototypic cancer family. Acta Paediatr Jpn. 1987 Aug; 29(4):526-33.
Hansen MF, Cavenee WK. PMID: 3144887.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Loss of heterozygosity in human ductal breast tumors indicates a recessive mutation on chromosome 13. Proc Natl Acad Sci U S A. 1987 Apr; 84(8):2372-6.
Lundberg C, Skoog L, Cavenee WK, Nordenskjöld M. PMID: 3031679; PMCID: PMC304653.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13. Proc Natl Acad Sci U S A. 1987 Jan; 84(2):512-6.
Griffin CA, Emanuel BS, Hansen JR, Cavenee WK, Myers JC. PMID: 3025878; PMCID: PMC304239.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Identification of recessive mutations at human cancer loci. Birth Defects Orig Artic Ser. 1987; 23(3):93-107.
Cavenee WK. PMID: 2820528.
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PubMed Mentions: Fields:
Translation:
Humans
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A primary genetic map of chromosome 13q. Am J Hum Genet. 1986 Oct; 39(4):425-37.
Leppert M, Cavenee W, Callahan P, Holm T, O'Connell P, Thompson K, Lathrop GM, Lalouel JM, White R. PMID: 3464200; PMCID: PMC1683981.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Recessive mutant genes predisposing to human cancer. Mutat Res. 1986 Jul; 168(1):3-14.
Cavenee WK, Koufos A, Hansen MF. PMID: 3012326.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Prediction of familial predisposition to retinoblastoma. N Engl J Med. 1986 May 08; 314(19):1201-7.
Cavenee WK, Murphree AL, Shull MM, Benedict WF, Sparkes RS, Kock E, Nordenskjold M. PMID: 3702916.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Molecular genetics of human familial cancer. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 2:829-35.
Cavenee WK, Hansen MF. PMID: 3472764.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Chromosome 13 homozygosity in osteosarcoma without retinoblastoma. Am J Hum Genet. 1986 Jan; 38(1):59-66.
Dryja TP, Rapaport JM, Epstein J, Goorin AM, Weichselbaum R, Koufos A, Cavenee WK. PMID: 3004203; PMCID: PMC1684712.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Recessive mutant genes predisposing to human cancer. Prog Clin Biol Res. 1986; 209A:575-82.
Cavenee WK. PMID: 3749067.
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Translation:
HumansCells
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Chromosomal mechanisms in the initiation of human familial mixed cancers. Princess Takamatsu Symp. 1986; 17:171-9.
Cavenee WK. PMID: 3332009.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6216-20.
Hansen MF, Koufos A, Gallie BL, Phillips RA, Fodstad O, Brøgger A, Gedde-Dahl T, Cavenee WK. PMID: 2994066; PMCID: PMC391023.
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PubMed Mentions:
99 Fields:
Translation:
HumansCells
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Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. Nature. 1985 Jul 25-31; 316(6026):330-4.
Koufos A, Hansen MF, Copeland NG, Jenkins NA, Lampkin BC, Cavenee WK. PMID: 2991766.
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PubMed Mentions:
102 Fields:
Translation:
HumansAnimalsCells
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Genetic origin of mutations predisposing to retinoblastoma. Science. 1985 Apr 26; 228(4698):501-3.
Cavenee WK, Hansen MF, Nordenskjold M, Kock E, Maumenee I, Squire JA, Phillips RA, Gallie BL. PMID: 3983638.
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PubMed Mentions:
68 Fields:
Translation:
HumansCells
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Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. Nature. 1984 May 10-16; 309(5964):170-2.
Koufos A, Hansen MF, Lampkin BC, Workman ML, Copeland NG, Jenkins NA, Cavenee WK. PMID: 6325936.
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PubMed Mentions:
125 Fields:
Translation:
HumansCells
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[Carrier diagnosis of retinoblastoma with molecular genetic methods]. Lakartidningen. 1984 Mar 21; 81(12):1183-92.
Nordenskjöld M, Cavenee WK, Kumlin E, Kock E. PMID: 6369047.
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PubMed Mentions: Fields:
Translation:
Humans
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Homozygosity of chromosome 13 in retinoblastoma. N Engl J Med. 1984 Mar 01; 310(9):550-3.
Dryja TP, Cavenee W, White R, Rapaport JM, Petersen R, Albert DM, Bruns GA. PMID: 6694706.
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PubMed Mentions:
53 Fields:
Translation:
HumansCells
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Isolation and regional localization of DNA segments revealing polymorphic loci from human chromosome 13. Am J Hum Genet. 1984 Jan; 36(1):10-24.
Cavenee W, Leach R, Mohandas T, Pearson P, White R. PMID: 6320640; PMCID: PMC1684373.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature. 1983 Oct 27-Nov 2; 305(5937):779-84.
Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphree AL, Strong LC, White RL. PMID: 6633649.
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PubMed Mentions:
448 Fields:
Translation:
HumansCells
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Characterization of dominant hamster cell mutants resistant to oxygenated sterols. Somatic Cell Genet. 1982 Sep; 8(5):557-74.
Cavenee WK, Baker RM. PMID: 7135162.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Regulation of cholesterol biosynthesis in enucleated cells. J Biol Chem. 1981 Mar 25; 256(6):2675-81.
Cavenee WK, Chen HW, Kandutsch AA. PMID: 7204371.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Cell-substratum and cell-monolayer adhesion are dependent upon cellular cholesterol biosynthesis. Exp Cell Res. 1981 Jan; 131(1):31-40.
Cavenee WK, Chen HW, Kandutsch AA. PMID: 7447988.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Regulation of cholesterol biosynthesis in cultured cells by probable natural precursor sterols. J Biol Chem. 1980 Jan 25; 255(2):395-400.
Gibbons GF, Pullinger CR, Chen HW, Cavenee WK, Kandutsch AA. PMID: 7356622.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Effects of various oxygenated sterols on cellular sterol biosynthesis in Chinese hamster lung cells resistant to 25-hydroxycholesterol. Biochim Biophys Acta. 1979 Nov 21; 575(2):255-65.
Cavenee WK, Gibbons GF, Chen HW, Kandutsch AA. PMID: 508785.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Sterol synthesis in variant Chinese hamster lung cells selected for resistance to 25-hydroxycholesterol. Cross-resistance to 7-ketocholesterol, 20alpha-hydroxycholesterol, and serum. J Biol Chem. 1979 Feb 10; 254(3):715-20.
Chen HW, Cavenee WK, Kandutsch AA. PMID: 762093.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Cholesterol biosynthesis in a variety of cultured cells. Lack of correlation between synthesis and activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase caused by dexamethasone. Biochim Biophys Acta. 1979 Jan 29; 572(1):188-92.
Johnston D, Cavenee WK, Ramachandran CK, Melnykovych G. PMID: 760799.
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HumansAnimalsCells
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Elevation of HeLa cell 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by glucocorticoids: possible relationship to the cell cycle. J Cell Physiol. 1979 Jan; 98(1):199-211.
Cavenee WK, Melnykovych G. PMID: 762197.
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Cells
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Regulation of cholesterol biosynthesis in HeLa S3G cells by serum lipoproteins: dexamethasone-mediated interference with suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Proc Natl Acad Sci U S A. 1978 May; 75(5):2103-7.
Cavenee WK, Johnston D, Melnykovych G. PMID: 209449; PMCID: PMC392499.
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2 Fields:
Translation:
Cells
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Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in HeLa cells by glucocorticoids. J Biol Chem. 1977 May 25; 252(10):3272-6.
Cavenee WK, Melnykovych G. PMID: 16889.
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5 Fields:
Translation:
Cells