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Karen Arden

Title(s)Adjunct Professor, Medicine
SchoolHealth Sciences
Phone858-534-7812
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. PMID: 28178237.
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    2. Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol. 2009 May; 10(5):504-13. PMID: 19363483.
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    3. Kim JJ, Li P, Huntley J, Chang JP, Arden KC, Olefsky JM. FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue. Diabetes. 2009 Jun; 58(6):1275-82. PMID: 19289458.
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    4. Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, DePinho RA, Rickert RC. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol. 2008 Dec; 9(12):1388-98. PMID: 18978794.
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    5. Arden KC. FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene. 2008 Apr 07; 27(16):2345-50. PMID: 18391976.
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    6. Roeb W, Boyer A, Cavenee WK, Arden KC. Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor. Cell Cycle. 2008 Apr 01; 7(7):837-41. PMID: 18414034.
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    7. Barrera LO, Li Z, Smith AD, Arden KC, Cavenee WK, Zhang MQ, Green RD, Ren B. Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Res. 2008 Jan; 18(1):46-59. PMID: 18042645.
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    8. Roeb W, Boyer A, Cavenee WK, Arden KC. PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18085-90. PMID: 17986608.
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    9. Arden KC. FoxOs in tumor suppression and stem cell maintenance. Cell. 2007 Jan 26; 128(2):235-7. PMID: 17254960.
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    10. Finckenstein FG, Davicioni E, Osborn KG, Cavenee WK, Arden KC, Anderson MJ. Transgenic mice expressing PAX3-FKHR have multiple defects in muscle development, including ectopic skeletal myogenesis in the developing neural tube. Transgenic Res. 2006 Oct; 15(5):595-614. PMID: 16952014.
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    11. Arden KC. Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp Gerontol. 2006 Aug; 41(8):709-17. PMID: 16806782.
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    12. Hashimoto N, Kido Y, Uchida T, Asahara S, Shigeyama Y, Matsuda T, Takeda A, Tsuchihashi D, Nishizawa A, Ogawa W, Fujimoto Y, Okamura H, Arden KC, Herrera PL, Noda T, Kasuga M. Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Nat Genet. 2006 May; 38(5):589-93. PMID: 16642023.
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    13. Djerassi C, Lewis AL, Altheide TK, Varki A, Arden K, Varki NM, Peekna A. Combining Parenting and a Science Career. Science. 2005 Mar 18; 307(5716):1720b-1721b. PMID: 15778202.
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    14. Lewis AL, Altheide TK, Varki A, Arden K, Varki NM. Combining parenting and a science career. Science. 2005 Mar 18; 307(5716):1720-1. PMID: 15779114.
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    15. Arden KC. FoxO: linking new signaling pathways. Mol Cell. 2004 May 21; 14(4):416-8. PMID: 15149589.
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    16. Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell. 2004 May 14; 117(4):421-6. PMID: 15137936.
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    17. Hosaka T, Biggs WH, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):2975-80. PMID: 14978268.
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    18. Stuart RO, Wachsman W, Berry CC, Wang-Rodriguez J, Wasserman L, Klacansky I, Masys D, Arden K, Goodison S, McClelland M, Wang Y, Sawyers A, Kalcheva I, Tarin D, Mercola D. In silico dissection of cell-type-associated patterns of gene expression in prostate cancer. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):615-20. PMID: 14722351.
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    19. Chen YT, Alpen B, Ono T, Gure AO, Scanlan MA, Biggs WH, Arden K, Nakayama E, Old LJ. Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression. Genomics. 2003 Dec; 82(6):628-36. PMID: 14611804.
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    20. Nakae J, Kitamura T, Kitamura Y, Biggs WH, Arden KC, Accili D. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell. 2003 Jan; 4(1):119-29. PMID: 12530968.
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    21. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest. 2002 Dec; 110(12):1839-47. PMID: 12488434.
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    22. Harding MA, Arden KC, Gildea JW, Gildea JJ, Perlman EJ, Viars C, Theodorescu D. Functional genomic comparison of lineage-related human bladder cancer cell lines with differing tumorigenic and metastatic potentials by spectral karyotyping, comparative genomic hybridization, and a novel method of positional expression profiling. Cancer Res. 2002 Dec 01; 62(23):6981-9. PMID: 12460916.
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    23. Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002 Oct; 32(2):245-53. PMID: 12219087.
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    24. Arden KC, Biggs WH. Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling. Arch Biochem Biophys. 2002 Jul 15; 403(2):292-8. PMID: 12139979.
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    25. Johnstone CN, White SJ, Tebbutt NC, Clay FJ, Ernst M, Biggs WH, Viars CS, Czekay S, Arden KC, Heath JK. Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression. J Biol Chem. 2002 Sep 13; 277(37):34531-9. PMID: 12114523.
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    26. Kawai K, Viars C, Arden K, Tarin D, Urquidi V, Goodison S. Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line. Genes Chromosomes Cancer. 2002 May; 34(1):1-8. PMID: 11921276.
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    27. Biggs WH, Cavenee WK, Arden KC. Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome. 2001 Jun; 12(6):416-25. PMID: 11353388.
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    28. Stan RV, Arden KC, Palade GE. cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes. Genomics. 2001 Mar 15; 72(3):304-13. PMID: 11401446.
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    29. Anderson MJ, Shelton GD, Cavenee WK, Arden KC. Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1589-94. PMID: 11171995.
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    30. Cardó-Vila M, Arden KC, Cavenee WK, Pasqualini R, Arap W. Is annexin 7 a tumor suppressor gene in prostate cancer? Pharmacogenomics J. 2001; 1(2):92-4. PMID: 11911446.
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    31. Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H. p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. Gene. 2000 Oct 17; 257(1):23-31. PMID: 11054565.
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    32. Clark ME, Kelner GS, Turbeville LA, Boyer A, Arden KC, Maki RA. ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family. Genomics. 2000 Aug 01; 67(3):343-50. PMID: 10936055.
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    33. Güre AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT. CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis. Int J Cancer. 2000 Mar 01; 85(5):726-32. PMID: 10699956.
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    34. Hyatt MA, Sykes VW, Boyer AD, Arden KC, Bögler O. Assignment of seta to distal mouse X chromosome by radiation hybrid mapping. Cytogenet Cell Genet. 2000; 89(3-4):278. PMID: 10965144.
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    35. Rader K, Boyer AD, Farquhar MG, Arden KC. Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to human chromosome 5q12-->q13 by radiation hybrid mapping and somatic cell hybrid PCR. Cytogenet Cell Genet. 2000; 89(3-4):164-5. PMID: 10965114.
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    36. Knudsen KE, Weber E, Arden KC, Cavenee WK, Feramisco JR, Knudsen ES. The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death. Oncogene. 1999 Sep 16; 18(37):5239-45. PMID: 10498874.
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    37. Wieland I, Arden KC, Michels D, Klein-Hitpass L, Böhm M, Viars CS, Weidle UH. Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. Oncogene. 1999 Aug 12; 18(32):4530-7. PMID: 10467397.
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    38. De Backer O, Arden KC, Boretti M, Vantomme V, De Smet C, Czekay S, Viars CS, De Plaen E, Brasseur F, Chomez P, Van den Eynde B, Boon T, van der Bruggen P. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. Cancer Res. 1999 Jul 01; 59(13):3157-65. PMID: 10397259.
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    39. Biggs WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7421-6. PMID: 10377430.
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    40. Knudsen KE, Cavenee WK, Arden KC. D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res. 1999 May 15; 59(10):2297-301. PMID: 10344732.
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    41. Wang HY, Arden KC, Bermingham JR, Viars CS, Lin W, Boyer AD, Fu XD. Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Genomics. 1999 Apr 15; 57(2):310-5. PMID: 10198174.
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    42. Scanlan MJ, Williamson B, Jungbluth A, Stockert E, Arden KC, Viars CS, Gure AO, Gordan JD, Chen YT, Old LJ. Isoforms of the human PDZ-73 protein exhibit differential tissue expression. Biochim Biophys Acta. 1999 Apr 14; 1445(1):39-52. PMID: 10209257.
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    43. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999 Mar 19; 96(6):857-68. PMID: 10102273.
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    44. Tishkoff DX, Amin NS, Viars CS, Arden KC, Kolodner RD. Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination. Cancer Res. 1998 Nov 15; 58(22):5027-31. PMID: 9823303.
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    45. Knudsen KE, Arden KC, Cavenee WK. Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells. J Biol Chem. 1998 Aug 07; 273(32):20213-22. PMID: 9685369.
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    46. Knudsen ES, Pazzagli C, Born TL, Bertolaet BL, Knudsen KE, Arden KC, Henry RR, Feramisco JR. Elevated cyclins and cyclin-dependent kinase activity in the rhabdomyosarcoma cell line RD. Cancer Res. 1998 May 01; 58(9):2042-9. PMID: 9581851.
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    47. Lucas S, De Smet C, Arden KC, Viars CS, Lethé B, Lurquin C, Boon T. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. Cancer Res. 1998 Feb 15; 58(4):743-52. PMID: 9485030.
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    48. Albertoni M, Daub DM, Arden KC, Viars CS, Powell C, Van Meir EG. Genetic instability leads to loss of both p53 alleles in a human glioblastoma. Oncogene. 1998 Jan 22; 16(3):321-6. PMID: 9467957.
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    49. Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics. 1998 Jan 15; 47(2):187-99. PMID: 9479491.
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    50. Hansen L, Arden KC, Rasmussen SB, Viars CS, Vestergaard H, Hansen T, Møller AM, Woodgett JR, Pedersen O. Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM. Diabetologia. 1997 Aug; 40(8):940-6. PMID: 9267989.
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    51. Schwarz H, Arden K, Lotz M. CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies. Biochem Biophys Res Commun. 1997 Jun 27; 235(3):699-703. PMID: 9207223.
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    52. Herbst RA, Gutzmer R, Matiaske F, Mommert S, Kapp A, Weiss J, Arden KC, Cavenee WK. Further evidence for ultraviolet light induction of CDKN2 (p16INK4) mutations in sporadic melanoma in vivo. J Invest Dermatol. 1997 Jun; 108(6):950. PMID: 9182829.
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    53. Chen YT, Boyer AD, Viars CS, Tsang S, Old LJ, Arden KC. Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28. Cytogenet Cell Genet. 1997; 79(3-4):237-40. PMID: 9605863.
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    54. Bigby TD, Hodulik CR, Arden KC, Fu L. Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35. Mol Med. 1996 Sep; 2(5):637-46. PMID: 8898379.
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    55. Arden KC, Anderson MJ, Finckenstein FG, Czekay S, Cavenee WK. Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction. Genes Chromosomes Cancer. 1996 Aug; 16(4):254-60. PMID: 8875239.
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    56. Wieland I, Böhm M, Arden KC, Ammermüller T, Bogatz S, Viars CS, Rajewsky MF. Allelic deletion mapping on chromosome 5 in human carcinomas. Oncogene. 1996 Jan 04; 12(1):97-102. PMID: 8552404.
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    57. Kermouni A, Van Roost E, Arden KC, Vermeesch JR, Weiss S, Godelaine D, Flint J, Lurquin C, Szikora JP, Higgs DR. The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter. Genomics. 1995 Sep 20; 29(2):371-82. PMID: 8666384.
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    58. Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, Khotz J, Manley JL, Rosenfeld MG. Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). Genomics. 1995 Sep 01; 29(1):70-9. PMID: 8530103.
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    59. Herbst RA, Larson A, Weiss J, Cavenee WK, Hampton GM, Arden KC. A defined region of loss of heterozygosity at 11q23 in cutaneous malignant melanoma. Cancer Res. 1995 Jun 15; 55(12):2494-6. PMID: 7780954.
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    60. Arden KC, Viars CS, Weiss S, Argentin S, Nemer M. Localization of the human B-type natriuretic peptide precursor (NPPB) gene to chromosome 1p36. Genomics. 1995 Mar 20; 26(2):385-9. PMID: 7601467.
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    61. Arden KC, Viars CS, Fu K, Rozen R. Localization of short/branched chain acyl-CoA dehydrogenase (ACADSB) to human chromosome 10. Genomics. 1995 Feb 10; 25(3):743-5. PMID: 7759115.
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    62. Weiss J, Heine M, Arden KC, Körner B, Pilch H, Herbst RA, Jung EG. Mutation and expression of TP53 in malignant melanomas. Recent Results Cancer Res. 1995; 139:137-54. PMID: 7597286.
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    63. Herbst RA, Nobori T, Cavenee WK, Carson DA, Arden KC. Dinucleotide repeat polymorphism adjacent to CDKN2. Hum Mol Genet. 1994 Dec; 3(12):2265. PMID: 7881438.
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    64. Herbst RA, Weiss J, Ehnis A, Cavenee WK, Arden KC. Loss of heterozygosity for 10q22-10qter in malignant melanoma progression. Cancer Res. 1994 Jun 15; 54(12):3111-4. PMID: 8205526.
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    65. Gessler M, König A, Arden K, Grundy P, Orkin S, Sallan S, Peters C, Ruyle S, Mandell J, Li F. Infrequent mutation of the WT1 gene in 77 Wilms' Tumors. Hum Mutat. 1994; 3(3):212-22. PMID: 8019557.
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    66. Weiss J, Rubinfeld B, Polakis PG, McCormick F, Cavenee WK, Arden KC. The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35. Cytogenet Cell Genet. 1994; 66(1):18-21. PMID: 8275700.
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    67. De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, van der Bruggen P, Lethé B, Lurquin C. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. Immunogenetics. 1994; 40(5):360-9. PMID: 7927540.
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    68. Weiss J, Cavenee WK, Herbst RA, Jung EG, Arden KC. Point mutations and allelic loss in the TP53 locus of cutaneous malignant melanomas. Arch Dermatol Res. 1994; 286(7):417-9. PMID: 7818283.
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    69. Gessler M, König A, Moore J, Qualman S, Arden K, Cavenee W, Bruns G. Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome. Genes Chromosomes Cancer. 1993 Jul; 7(3):131-6. PMID: 7687865.
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    70. Weiss J, Schwechheimer K, Cavenee WK, Herlyn M, Arden KC. Mutation and expression of the p53 gene in malignant melanoma cell lines. Int J Cancer. 1993 Jun 19; 54(4):693-9. PMID: 8514460.
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    71. Phaneuf D, Labelle Y, Bérubé D, Arden K, Cavenee W, Gagné R, Tanguay RM. Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15. Am J Hum Genet. 1991 Mar; 48(3):525-35. PMID: 1998338.
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    72. Houwen RH, Pautler SE, Barwell JA, Arden K, Buchanan JA, James CD, Cavenee WK, Buys CH, Cowell JK, Cox DW. Isolation and regional localization of 25 anonymous DNA probes on a chromosome 13 hybrid panel. Cytogenet Cell Genet. 1991; 57(2-3):87-90. PMID: 1914527.
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    73. Testa JR, Park M, Blair DG, Kalbakji A, Arden K, Vande Woude GF. Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS. Oncogene. 1990 Oct; 5(10):1565-71. PMID: 2250912.
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    74. Arden KC, Boutin JM, Djiane J, Kelly PA, Cavenee WK. The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5. Cytogenet Cell Genet. 1990; 53(2-3):161-5. PMID: 2369845.
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    75. Arden KC, Pathak S, Swartzendruber DE, Zimmer SG. Cytogenetic characterization and DNA content analysis of Ad 2-transformed rat embryo brain cells. Anticancer Res. 1984 Nov-Dec; 4(6):367-74. PMID: 6595960.
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