Frank Furnari

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Biophysical Interrogation of Signals that Drive GBM Invasion
    NIH R01NS116802May 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Genotypic Interactions in Brain Cancer Heterogeneity
    NIH/NINDS R01NS080939Sep 1, 2012 - Mar 31, 2023
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo. Neuro Oncol. 2022 Dec 01; 24(12):2063-2075. Miki S, Koga T, Mckinney AM, Parisian AD, Tadokoro T, Vadla R, Marsala M, Hevner RF, Costello JF, Furnari F. PMID: 35325218; PMCID: PMC9713509.
      View in: PubMed   Mentions:    Fields:    
    2. PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors. Neuro Oncol. 2022 11 02; 24(11):1857-1868. Ferdosi SR, Taylor B, Lee M, Tang N, Peng S, Bybee R, Reid G, Hartman L, Garcia-Mansfield K, Sharma R, Pirrotte P, Ma J, Parisian AD, Furnari F, Dhruv HD, Berens ME. PMID: 35305088; PMCID: PMC9629460.
      View in: PubMed   Mentions:    Fields:    
    3. The impact of phosphorylated PTEN at threonine 366 on cortical connectivity and behaviour. Brain. 2022 10 21; 145(10):3608-3621. Ledderose JMT, Benitez JA, Roberts AJ, Reed R, Bintig W, Larkum ME, Sachdev RNS, Furnari F, Eickholt BJ. PMID: 35603900.
      View in: PubMed   Mentions:    Fields:    
    4. Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. Cell Rep. 2021 11 02; 37(5):109957. Bi J, Khan A, Tang J, Armando AM, Wu S, Zhang W, Gimple RC, Reed A, Jing H, Koga T, Wong IT, Gu Y, Miki S, Yang H, Prager B, Curtis EJ, Wainwright DA, Furnari FB, Rich JN, Cloughesy TF, Kornblum HI, Quehenberger O, Rzhetsky A, Cravatt BF, Mischel PS. PMID: 34731610; PMCID: PMC8856626.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. PTEN deficiency leads to proteasome addiction: a novel vulnerability in glioblastoma. Neuro Oncol. 2021 07 01; 23(7):1072-1086. Benitez JA, Finlay D, Castanza A, Parisian AD, Ma J, Longobardi C, Campos A, Vadla R, Izurieta A, Scerra G, Koga T, Long T, Chavez L, Mesirov JP, Vuori K, Furnari F. PMID: 33428749; PMCID: PMC8661409.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. A Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas. Front Oncol. 2021; 11:652133. Jandrey EHF, Bezerra M, Inoue LT, Furnari FB, Camargo AA, Costa ÉT. PMID: 34178638; PMCID: PMC8222785.
      View in: PubMed   Mentions: 1  
    7. PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). Li J, Kaneda MM, Ma J, Li M, Shepard RM, Patel K, Koga T, Sarver A, Furnari F, Xu B, Dhawan S, Ning J, Zhu H, Wu A, You G, Jiang T, Venteicher AS, Rich JN, Glass CK, Varner JA, Chen CC. PMID: 33846242; PMCID: PMC8072253.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    8. Epidermal growth factor receptor as a molecular determinant of glioblastoma response to dopamine receptor D2 inhibitors. Neuro Oncol. 2021 03 25; 23(3):400-411. He Y, Li J, Koga T, Ma J, Dhawan S, Suzuki Y, Furnari F, Prabhu VV, Allen JE, Chen CC. PMID: 32830856; PMCID: PMC7992877.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Sci Adv. 2021 02; 7(7). Oatman N, Dasgupta N, Arora P, Choi K, Gawali MV, Gupta N, Parameswaran S, Salomone J, Reisz JA, Lawler S, Furnari F, Brennan C, Wu J, Sallans L, Gudelsky G, Desai P, Gebelein B, Weirauch MT, D'Alessandro A, Komurov K, Dasgupta B. PMID: 33568479; PMCID: PMC7875532.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    10. EGFRvIII uses intrinsic and extrinsic mechanisms to reduce glioma adhesion and increase migration. J Cell Sci. 2020 12 24; 133(24). Banisadr A, Eick M, Beri P, Parisian AD, Yeoman B, Placone JK, Engler AJ, Furnari F. PMID: 33243756; PMCID: PMC7774888.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability. Genes Dev. 2020 10 01; 34(19-20):1316-1329. Parisian AD, Koga T, Miki S, Johann PD, Kool M, Crawford JR, Furnari FB. PMID: 32912900; PMCID: PMC7528703.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Genome Engineering Evolves Brain Tumor Modeling. Neurol Med Chir (Tokyo). 2020 Jul 15; 60(7):329-336. Koga T, Chen CC, Furnari FB. PMID: 32536682; PMCID: PMC7358782.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    13. Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas. EBioMedicine. 2020 May; 55:102736. Ramakrishnan V, Xu B, Akers J, Nguyen T, Ma J, Dhawan S, Ning J, Mao Y, Hua W, Kokkoli E, Furnari F, Carter BS, Chen CC. PMID: 32361246; PMCID: PMC7195524.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    14. Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020 04 20; 11(1):1958. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. PMID: 32312984; PMCID: PMC7171109.
      View in: PubMed   Mentions:    Fields:    
    15. Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020 Jan 28; 11(1):550. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. PMID: 31992716; PMCID: PMC6987220.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy. Cell Rep. 2020 01 28; 30(4):969-983.e4. Wang S, Zhang Q, Tiwari SK, Lichinchi G, Yau EH, Hui H, Li W, Furnari F, Rana TM. PMID: 31956073; PMCID: PMC7293422.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    17. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 Dec 09; 36(6):690-691. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 31821785; PMCID: PMC6946119.
      View in: PubMed   Mentions: 6     Fields:    
    18. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019 11; 575(7784):699-703. Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. PMID: 31748743; PMCID: PMC7094777.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    19. Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins. Mol Cancer Res. 2019 11; 17(11):2208-2220. Jameson NM, Ma J, Benitez J, Izurieta A, Han JY, Mendez R, Parisian A, Furnari F. PMID: 31444232; PMCID: PMC6825583.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019 09 03; 30(3):525-538.e8. Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. PMID: 31303424; PMCID: PMC6742496.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    21. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 May 13; 35(5):816. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 31085179; PMCID: PMC8717880.
      View in: PubMed   Mentions: 10     Fields:    
    22. Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):10009-10018. Orellana L, Thorne AH, Lema R, Gustavsson J, Parisian AD, Hospital A, Cordeiro TN, Bernadó P, Scott AM, Brun-Heath I, Lindahl E, Cavenee WK, Furnari FB, Orozco M. PMID: 31028138; PMCID: PMC6525488.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    23. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. Nature. 2019 05; 569(7757):570-575. Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS. PMID: 31019297; PMCID: PMC7138021.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    24. When less is more: Gaining power through gene rearrangement of amplified EGFR. Oncotarget. 2019 Mar 15; 10(22):2116-2117. Koga T, Chen CC, Furnari FB. PMID: 31040904; PMCID: PMC6481334.
      View in: PubMed   Mentions: 1     Fields:    
    25. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 03 18; 35(3):504-518.e7. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 30827889; PMCID: PMC6424615.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    26. Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk. Cancer Res. 2019 03 15; 79(6):1239-1251. Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, Ljubimov VA, Shatalova ES, Wagner S, Li D, Mamelak AN, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Lyubimov AV, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY. PMID: 30659021; PMCID: PMC6625517.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    27. Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development. Neuro Oncol. 2018 09 03; 20(10):1310-1320. Koga T, Li B, Figueroa JM, Ren B, Chen CC, Carter BS, Furnari FB. PMID: 29660021; PMCID: PMC6120357.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin. Autophagy. 2018; 14(10):1845-1846. Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 30118375; PMCID: PMC6135626.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    29. Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. Cancer Cell. 2018 07 09; 34(1):163-177.e7. Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM. PMID: 29990498; PMCID: PMC6424337.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    30. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596; PMCID: PMC6195840.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    31. Publisher Correction: PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2018 05 25; 9:16217. Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB. PMID: 29799523; PMCID: PMC6026911.
      View in: PubMed   Mentions: 1     Fields:    
    32. MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5768-5773. Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 29760085; PMCID: PMC5984507.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    33. Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts. J Vis Exp. 2018 04 26; (134). Benitez JA, Zanca C, Ma J, Cavenee WK, Furnari FB. PMID: 29757276; PMCID: PMC6100979.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. FHL2 interacts with EGFR to promote glioblastoma growth. Oncogene. 2018 03; 37(10):1386-1398. Sun L, Yu S, Xu H, Zheng Y, Lin J, Wu M, Wang J, Wang A, Lan Q, Furnari F, Cavenee W, Purow B, Li M. PMID: 29321665; PMCID: PMC8691187.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    35. Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity. Genes Dev. 2017 06 15; 31(12):1212-1227. Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee WK, Furnari FB. PMID: 28724615; PMCID: PMC5558924.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    36. PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2017 05 12; 8:15223. Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB. PMID: 28497778; PMCID: PMC5437297.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    37. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237; PMCID: PMC5334176.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansCells
    38. Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):370-375. Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, Hu B, Emdad L, Valerie K, Sarkar D, Furnari FB, Cavenee WK, Wei J, Purves A, De SK, Pellecchia M, Fisher PB. PMID: 28011764; PMCID: PMC5240699.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    39. Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme. J Control Release. 2016 12 28; 244(Pt A):14-23. Chou ST, Patil R, Galstyan A, Gangalum PR, Cavenee WK, Furnari FB, Ljubimov VA, Chesnokova A, Kramerov AA, Ding H, Falahatian V, Mashouf L, Fox I, Black KL, Holler E, Ljubimov AV, Ljubimova JY. PMID: 27825958; PMCID: PMC5308909.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    40. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. 2016 Nov 14; 30(5):683-693. Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. PMID: 27746144; PMCID: PMC5479636.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    41. The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-). Cancer Res. 2016 05 15; 76(10):2954-63. Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H, Nagano O. PMID: 26980765; PMCID: PMC4873328.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    42. Epidermal growth factor receptor targeting and challenges in glioblastoma. Neuro Oncol. 2016 07; 18(7):914-8. Thorne AH, Zanca C, Furnari F. PMID: 26755074; PMCID: PMC4896544.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    43. EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. Mol Cell. 2015 Oct 15; 60(2):307-18. Liu F, Hon GC, Villa GR, Turner KM, Ikegami S, Yang H, Ye Z, Li B, Kuan S, Lee AY, Zanca C, Wei B, Lucey G, Jenkins D, Zhang W, Barr CL, Furnari FB, Cloughesy TF, Yong WH, Gahman TC, Shiau AK, Cavenee WK, Ren B, Mischel PS. PMID: 26455392; PMCID: PMC4609298.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    44. Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition. Oncotarget. 2015 May 20; 6(14):11751-67. Shen Y, Li J, Nitta M, Futalan D, Steed T, Treiber JM, Taich Z, Stevens D, Wykosky J, Chen HZ, Carter BS, Becher OJ, Kennedy R, Esashi F, Sarkaria JN, Furnari FB, Cavenee WK, Desai A, Chen CC. PMID: 26059434; PMCID: PMC4494902.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    45. Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma. Nat Rev Cancer. 2015 May; 15(5):302-10. Furnari FB, Cloughesy TF, Cavenee WK, Mischel PS. PMID: 25855404; PMCID: PMC4875778.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCells
    46. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29; 160(3):489-502. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. PMID: 25619690; PMCID: PMC4313737.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    47. A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer Res. 2015 Jan 15; 75(2):394-404. Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee WK, Furnari FB. PMID: 25432173; PMCID: PMC4297573.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    48. Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. Oncogene. 2015 Jul 30; 34(31):4078-88. Hu J, Muller KA, Furnari FB, Cavenee WK, VandenBerg SR, Gonias SL. PMID: 25347738; PMCID: PMC4411189.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    49. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3741-56. Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY. PMID: 25061874; PMCID: PMC4151226.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    50. A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul 01; 7(332):pe15. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. PMID: 24985344; PMCID: PMC4367864.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
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    106. Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9936-41. Chuenkova MV, Furnari FB, Cavenee WK, Pereira MA. PMID: 11481434; PMCID: PMC55556.
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    107. Malignant glioma: genetics and biology of a grave matter. Genes Dev. 2001 Jun 01; 15(11):1311-33. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. PMID: 11390353.
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    108. Non-isotopic silver-stained SSCP is more sensitive than automated direct sequencing for the detection of PTEN mutations in a mixture of DNA extracted from normal and tumor cells. Int J Oncol. 2001 May; 18(5):1023-6. Fan X, Furnari FB, Cavenee WK, Castresana JS. PMID: 11295051.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    109. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene. 2000 May 18; 19(22):2687-94. Reiss K, Wang JY, Romano G, Furnari FB, Cavenee WK, Morrione A, Tu X, Baserga R. PMID: 10851068.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    110. SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes. Neuro Oncol. 2000 01; 2(1):6-15. Bögler O, Furnari FB, Kindler-Roehrborn A, Sykes VW, Yung R, Huang HJ, Cavenee WK. PMID: 11302255; PMCID: PMC1920697.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    111. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. 1999 Jul 08; 18(27):3936-43. Wick W, Furnari FB, Naumann U, Cavenee WK, Weller M. PMID: 10435616.
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    112. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res. 1998 Nov 15; 58(22):5002-8. Furnari FB, Huang HJ, Cavenee WK. PMID: 9823298.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    113. In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9418-23. Robertson GP, Furnari FB, Miele ME, Glendening MJ, Welch DR, Fountain JW, Lugo TG, Huang HJ, Cavenee WK. PMID: 9689095; PMCID: PMC21353.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    114. Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. Cancer Res. 1998 Jul 01; 58(13):2724-6. Carethers JM, Furnari FB, Zigman AF, Lavine JE, Jones MC, Graham GE, Teebi AS, Huang HJ, Ha HT, Chauhan DP, Chang CL, Cavenee WK, Boland CR. PMID: 9661881.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    115. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12479-84. Furnari FB, Lin H, Huang HS, Cavenee WK. PMID: 9356475; PMCID: PMC25009.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    116. Molecular biology of malignant degeneration of astrocytoma. Pediatr Neurosurg. 1996; 24(1):41-9. Furnari FB, Huang HJ, Cavenee WK. PMID: 8817614.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    117. Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res. 1995 May 01; 55(9):1941-5. Nishikawa R, Furnari FB, Lin H, Arap W, Berger MS, Cavenee WK, Su Huang HJ. PMID: 7728764.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    118. Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res. 1995 Mar 15; 55(6):1351-4. Arap W, Nishikawa R, Furnari FB, Cavenee WK, Huang HJ. PMID: 7882335.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    119. Genetics and malignant progression of human brain tumours. Cancer Surv. 1995; 25:233-75. Furnari FB, Huang HJ, Cavenee WK. PMID: 8718522.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    120. RAZ, an Epstein-Barr virus transdominant repressor that modulates the viral reactivation mechanism. J Virol. 1994 Mar; 68(3):1827-36. Furnari FB, Zacny V, Quinlivan EB, Kenney S, Pagano JS. PMID: 8107245; PMCID: PMC236645.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    121. Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):378-82. Furnari FB, Adams MD, Pagano JS. PMID: 8093641; PMCID: PMC45665.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    122. Regulation of the Epstein-Barr virus DNA polymerase gene. J Virol. 1992 May; 66(5):2837-45. Furnari FB, Adams MD, Pagano JS. PMID: 1313904; PMCID: PMC241041.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
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