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Frank Furnari

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Biophysical Interrogation of Signals that Drive GBM Invasion
    NIH R01NS116802May 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Genotypic Interactions in Brain Cancer Heterogeneity
    NIH/NINDS R01NS080939Sep 1, 2012 - Mar 31, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PI3K? inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci U S A. 2021 Apr 20; 118(16). PMID: 33846242.
      View in: PubMed   Mentions:    Fields:    
    2. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Sci Adv. 2021 Feb; 7(7). Oatman N, Dasgupta N, Arora P, Choi K, Gawali MV, Gupta N, Parameswaran S, Salomone J, Reisz JA, Lawler S, Furnari F, Brennan C, Wu J, Sallans L, Gudelsky G, Desai P, Gebelein B, Weirauch MT, D'Alessandro A, Komurov K, Dasgupta B. PMID: 33568479.
      View in: PubMed   Mentions:    Fields:    
    3. Pten Deficiency Leads To Proteasome Addiction, A Novel Vulnerability In Glioblastoma. Neuro Oncol. 2021 Jan 11. Benitez JA, Finlay D, Castanza A, Parisian AD, Ma J, Longobardi C, Campos A, Vadla R, Izurieta A, Scerra G, Koga T, Long T, Chavez L, Mesirov JP, Vuori K, Furnari F. PMID: 33428749.
      View in: PubMed   Mentions:    Fields:    
    4. EGFRvIII uses intrinsic and extrinsic mechanisms to reduce glioma adhesion and increase migration. J Cell Sci. 2020 Nov 26. Banisadr A, Eick M, Beri P, Parisian AD, Yeoman B, Placone JK, Engler AJ, Furnari F. PMID: 33243756.
      View in: PubMed   Mentions:    Fields:    
    5. SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability. Genes Dev. 2020 Oct 01; 34(19-20):1316-1329. Parisian AD, Koga T, Miki S, Johann PD, Kool M, Crawford JR, Furnari FB. PMID: 32912900.
      View in: PubMed   Mentions:    Fields:    
    6. Epidermal Growth Factor Receptor (EGFR) as a molecular determinant of glioblastoma response to dopamine receptor 2 (DRD2) inhibitors. Neuro Oncol. 2020 Aug 24. He Y, Li J, Koga T, Ma J, Dhawan S, Suzuki Y, Furnari F, Prabhu VV, Allen JE, Chen CC. PMID: 32830856.
      View in: PubMed   Mentions:    Fields:    
    7. Genome Engineering Evolves Brain Tumor Modeling. Neurol Med Chir (Tokyo). 2020 Jul 15; 60(7):329-336. Koga T, Chen CC, Furnari FB. PMID: 32536682.
      View in: PubMed   Mentions: 1     Fields:    
    8. Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas. EBioMedicine. 2020 May; 55:102736. Ramakrishnan V, Xu B, Akers J, Nguyen T, Ma J, Dhawan S, Ning J, Mao Y, Hua W, Kokkoli E, Furnari F, Carter BS, Chen CC. PMID: 32361246.
      View in: PubMed   Mentions: 1     Fields:    
    9. Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020 04 20; 11(1):1958. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. PMID: 32312984.
      View in: PubMed   Mentions:    Fields:    
    10. Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020 Jan 28; 11(1):550. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. PMID: 31992716.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Integrin avß5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy. Cell Rep. 2020 01 28; 30(4):969-983.e4. Wang S, Zhang Q, Tiwari SK, Lichinchi G, Yau EH, Hui H, Li W, Furnari F, Rana TM. PMID: 31956073.
      View in: PubMed   Mentions: 6     Fields:    
    12. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 Dec 09; 36(6):690-691. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 31821785.
      View in: PubMed   Mentions: 3     Fields:    
    13. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019 11; 575(7784):699-703. Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. PMID: 31748743.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    14. Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins. Mol Cancer Res. 2019 11; 17(11):2208-2220. Jameson NM, Ma J, Benitez J, Izurieta A, Han JY, Mendez R, Parisian A, Furnari F. PMID: 31444232.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019 09 03; 30(3):525-538.e8. Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. PMID: 31303424.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 May 13; 35(5):816. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 31085179.
      View in: PubMed   Mentions: 6     Fields:    
    17. Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):10009-10018. Orellana L, Thorne AH, Lema R, Gustavsson J, Parisian AD, Hospital A, Cordeiro TN, Bernadó P, Scott AM, Brun-Heath I, Lindahl E, Cavenee WK, Furnari FB, Orozco M. PMID: 31028138.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    18. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. Nature. 2019 05; 569(7757):570-575. Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS. PMID: 31019297.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    19. When less is more: Gaining power through gene rearrangement of amplified EGFR. Oncotarget. 2019 Mar 15; 10(22):2116-2117. Koga T, Chen CC, Furnari FB. PMID: 31040904.
      View in: PubMed   Mentions:    Fields:    
    20. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 03 18; 35(3):504-518.e7. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 30827889.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk. Cancer Res. 2019 03 15; 79(6):1239-1251. Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, Ljubimov VA, Shatalova ES, Wagner S, Li D, Mamelak AN, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Lyubimov AV, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY. PMID: 30659021.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development. Neuro Oncol. 2018 09 03; 20(10):1310-1320. Koga T, Li B, Figueroa JM, Ren B, Chen CC, Carter BS, Furnari FB. PMID: 29660021.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin. Autophagy. 2018; 14(10):1845-1846. Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 30118375.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. Cancer Cell. 2018 07 09; 34(1):163-177.e7. Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM. PMID: 29990498.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    25. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    26. Publisher Correction: PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2018 05 25; 9:16217. Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB. PMID: 29799523.
      View in: PubMed   Mentions:    Fields:    
    27. MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5768-5773. Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 29760085.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    28. Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts. J Vis Exp. 2018 04 26; (134). Benitez JA, Zanca C, Ma J, Cavenee WK, Furnari FB. PMID: 29757276.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    29. FHL2 interacts with EGFR to promote glioblastoma growth. Oncogene. 2018 03; 37(10):1386-1398. Sun L, Yu S, Xu H, Zheng Y, Lin J, Wu M, Wang J, Wang A, Lan Q, Furnari F, Cavenee W, Purow B, Li M. PMID: 29321665.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    30. Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity. Genes Dev. 2017 06 15; 31(12):1212-1227. Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee WK, Furnari FB. PMID: 28724615.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    31. PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2017 05 12; 8:15223. Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB. PMID: 28497778.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    32. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    33. Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):370-375. Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, Hu B, Emdad L, Valerie K, Sarkar D, Furnari FB, Cavenee WK, Wei J, Purves A, De SK, Pellecchia M, Fisher PB. PMID: 28011764.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    34. Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme. J Control Release. 2016 12 28; 244(Pt A):14-23. Chou ST, Patil R, Galstyan A, Gangalum PR, Cavenee WK, Furnari FB, Ljubimov VA, Chesnokova A, Kramerov AA, Ding H, Falahatian V, Mashouf L, Fox I, Black KL, Holler E, Ljubimov AV, Ljubimova JY. PMID: 27825958.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    35. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. 2016 Nov 14; 30(5):683-693. Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. PMID: 27746144.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    36. The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-). Cancer Res. 2016 05 15; 76(10):2954-63. Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H, Nagano O. PMID: 26980765.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    37. Epidermal growth factor receptor targeting and challenges in glioblastoma. Neuro Oncol. 2016 07; 18(7):914-8. Thorne AH, Zanca C, Furnari F. PMID: 26755074.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    38. EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. Mol Cell. 2015 Oct 15; 60(2):307-18. Liu F, Hon GC, Villa GR, Turner KM, Ikegami S, Yang H, Ye Z, Li B, Kuan S, Lee AY, Zanca C, Wei B, Lucey G, Jenkins D, Zhang W, Barr CL, Furnari FB, Cloughesy TF, Yong WH, Gahman TC, Shiau AK, Cavenee WK, Ren B, Mischel PS. PMID: 26455392.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    39. Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition. Oncotarget. 2015 May 20; 6(14):11751-67. Shen Y, Li J, Nitta M, Futalan D, Steed T, Treiber JM, Taich Z, Stevens D, Wykosky J, Chen HZ, Carter BS, Becher OJ, Kennedy R, Esashi F, Sarkaria JN, Furnari FB, Cavenee WK, Desai A, Chen CC. PMID: 26059434.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    40. Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma. Nat Rev Cancer. 2015 May; 15(5):302-10. Furnari FB, Cloughesy TF, Cavenee WK, Mischel PS. PMID: 25855404.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    41. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29; 160(3):489-502. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. PMID: 25619690.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    42. A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer Res. 2015 Jan 15; 75(2):394-404. Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee WK, Furnari FB. PMID: 25432173.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    43. Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. Oncogene. 2015 Jul 30; 34(31):4078-88. Hu J, Muller KA, Furnari FB, Cavenee WK, VandenBerg SR, Gonias SL. PMID: 25347738.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    44. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3741-56. Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY. PMID: 25061874.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    45. A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul 01; 7(332):pe15. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. PMID: 24985344.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    46. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. Oncogene. 2015 Mar 05; 34(10):1270-9. Costa ET, Barnabé GF, Li M, Dias AA, Machado TR, Asprino PF, Cavalher FP, Ferreira EN, Del Mar Inda M, Nagai MH, Malnic B, Duarte ML, Leite KR, de Barros AC, Carraro DM, Chammas R, Armelin HA, Cavenee W, Furnari F, Camargo AA. PMID: 24662834.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    47. Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. 2014 Feb 28; 5(4):882-93. Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen CC. PMID: 24658464.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    48. Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer Res. 2014 Mar 01; 74(5):1429-39. Gomez GG, Volinia S, Croce CM, Zanca C, Li M, Emnett R, Gutmann DH, Brennan CW, Furnari FB, Cavenee WK. PMID: 24436148.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    49. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 2014 Jan 03; 343(6166):72-6. Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS. PMID: 24310612.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    50. Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks. Cancer Biol Med. 2013 Dec; 10(4):192-205. Gomez GG, Wykosky J, Zanca C, Furnari FB, Cavenee WK. PMID: 24349829.
      View in: PubMed   Mentions:
    51. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15; 19(20):5722-32. Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee WK, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. PMID: 24030701.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    52. EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180. Oncogene. 2014 May 08; 33(19):2504-12. Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng SY. PMID: 23728337.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    53. A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments. Carcinogenesis. 2013 Apr; 34(4):725-38. Masui K, Gini B, Wykosky J, Zanca C, Mischel PS, Furnari FB, Cavenee WK. PMID: 23455378.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    54. PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4339-44. Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, Dang J, Yang H, Zhu S, Kohyama J, Kitabayashi I, Cavenee WK, Cloughesy TF, Furnari FB, Nakamura M, Toyama Y, Okano H, Mischel PS. PMID: 23440206.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    55. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS Genet. 2013; 9(2):e1003253. Read RD, Fenton TR, Gomez GG, Wykosky J, Vandenberg SR, Babic I, Iwanami A, Yang H, Cavenee WK, Mischel PS, Furnari FB, Thomas JB. PMID: 23459592.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    56. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14164-9. Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB. PMID: 22891331.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    57. Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter. Int J Cancer. 2013 Feb 01; 132(3):509-20. Latha K, Li M, Chumbalkar V, Gururaj A, Hwang Y, Dakeng S, Sawaya R, Aldape K, Cavenee WK, Bogler O, Furnari FB. PMID: 22729867.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    58. Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev. 2012 Apr 15; 26(8):756-84. Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, Chin L, Hahn WC. PMID: 22508724.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansCells
    59. Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance. Curr Cancer Drug Targets. 2012 Mar; 12(3):197-209. Taylor TE, Furnari FB, Cavenee WK. PMID: 22268382.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    60. Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3018-23. Feng H, Hu B, Jarzynka MJ, Li Y, Keezer S, Johns TG, Tang CK, Hamilton RL, Vuori K, Nishikawa R, Sarkaria JN, Fenton T, Cheng T, Furnari FB, Cavenee WK, Cheng SY. PMID: 22323579.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    61. Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma. J Exp Med. 2011 Dec 19; 208(13):2657-73. Li M, Mukasa A, Inda MM, Zhang J, Chin L, Cavenee W, Furnari F. PMID: 22162832.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    62. EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway. Oncogene. 2012 Sep 06; 31(36):4054-66. Bonavia R, Inda MM, Vandenberg S, Cheng SY, Nagane M, Hadwiger P, Tan P, Sah DW, Cavenee WK, Furnari FB. PMID: 22139077.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    63. Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRa-stimulated glioma tumorigenesis in mice and humans. J Clin Invest. 2011 Dec; 121(12):4670-84. Feng H, Hu B, Liu KW, Li Y, Lu X, Cheng T, Yiin JJ, Lu S, Keezer S, Fenton T, Furnari FB, Hamilton RL, Vuori K, Sarkaria JN, Nagane M, Nishikawa R, Cavenee WK, Cheng SY. PMID: 22080864.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    64. Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15984-9. Hu J, Jo M, Cavenee WK, Furnari F, VandenBerg SR, Gonias SL. PMID: 21896743.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    65. Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism. J Cell Sci. 2011 Sep 01; 124(Pt 17):2938-50. Cvrljevic AN, Akhavan D, Wu M, Martinello P, Furnari FB, Johnston AJ, Guo D, Pike L, Cavenee WK, Scott AM, Mischel PS, Hoogenraad NJ, Johns TG. PMID: 21878501.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    66. Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop. Neuro Oncol. 2011 Jul; 13(7):692-9. Gutmann DH, Stiles CD, Lowe SW, Bollag GE, Furnari FB, Charest AL. PMID: 21727208.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    67. MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. Mol Cancer Res. 2011 Aug; 9(8):1100-11. Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T. PMID: 21693595.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    68. Heterogeneity maintenance in glioblastoma: a social network. Cancer Res. 2011 Jun 15; 71(12):4055-60. Bonavia R, Inda MM, Cavenee WK, Furnari FB. PMID: 21628493.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    69. Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ?EGFR. J Proteome Res. 2011 Mar 04; 10(3):1343-52. Chumbalkar V, Latha K, Hwang Y, Maywald R, Hawley L, Sawaya R, Diao L, Baggerly K, Cavenee WK, Furnari FB, Bogler O. PMID: 21214269.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    70. Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations. Chin J Cancer. 2011 Jan; 30(1):5-12. Wykosky J, Fenton T, Furnari F, Cavenee WK. PMID: 21192840.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    71. Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. J Clin Invest. 2011 Jan; 121(1):161-73. Staquicini FI, Ozawa MG, Moya CA, Driessen WH, Barbu EM, Nishimori H, Soghomonyan S, Flores LG, Liang X, Paolillo V, Alauddin MM, Basilion JP, Furnari FB, Bogler O, Lang FF, Aldape KD, Fuller GN, Höök M, Gelovani JG, Sidman RL, Cavenee WK, Pasqualini R, Arap W. PMID: 21183793.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    72. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 2010 Aug 15; 24(16):1731-45. Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, Depinho RA, Cavenee W, Furnari F. PMID: 20713517.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    73. Gene-expression forum: Decoy for microRNAs. Nature. 2010 Jun 24; 465(7301):1016-7. Rigoutsos I, Furnari F. PMID: 20577197.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    74. Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One. 2010 May 24; 5(5):e10767. Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MM, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, D'Andrea A, Chen CC. PMID: 20532243.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    75. Escape from targeted inhibition: the dark side of kinase inhibitor therapy. . 2010 May; 9(9):1661-2. Wykosky J, Mukasa A, Furnari F, Cavenee WK. PMID: 20404502.
      View in: PubMed   Mentions:
    76. Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth. Mol Biosyst. 2010 Jul; 6(7):1227-37. Huang PH, Miraldi ER, Xu AM, Kundukulam VA, Del Rosario AM, Flynn RA, Cavenee WK, Furnari FB, White FM. PMID: 20461251.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    77. Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2616-21. Mukasa A, Wykosky J, Ligon KL, Chin L, Cavenee WK, Furnari F. PMID: 20133782.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    78. Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res. 2009 Sep 01; 69(17):6889-98. Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, Dang J, Dinca EB, Plaisier SB, Oderberg I, Lee Y, Chen Z, Caldwell JS, Xie Y, Loo JA, Seligson D, Chakravari A, Lee FY, Weinmann R, Cloughesy TF, Nelson SF, Bergers G, Graeber T, Furnari FB, James CD, Cavenee WK, Johns TG, Mischel PS. PMID: 19690143.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    79. EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma. Cancer Res. 2009 May 15; 69(10):4252-9. Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S. PMID: 19435898.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    80. A drosophila model for EGFR-Ras and PI3K-dependent human glioma. PLoS Genet. 2009 Feb; 5(2):e1000374. Read RD, Cavenee WK, Furnari FB, Thomas JB. PMID: 19214224.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    81. Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell. 2008 Apr; 13(4):355-64. Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L. PMID: 18394558.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    82. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007 Nov 01; 21(21):2683-710. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. PMID: 17974913.
      View in: PubMed   Mentions: 863     Fields:    Translation:HumansAnimals
    83. Uncovering therapeutic targets for glioblastoma: a systems biology approach. . 2007 Nov 15; 6(22):2750-4. Huang PH, Cavenee WK, Furnari FB, White FM. PMID: 17986864.
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    84. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12867-72. Huang PH, Mukasa A, Bonavia R, Flynn RA, Brewer ZE, Cavenee WK, Furnari FB, White FM. PMID: 17646646.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    85. The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization. Clin Cancer Res. 2007 Mar 15; 13(6):1911-25. Johns TG, Perera RM, Vernes SC, Vitali AA, Cao DX, Cavenee WK, Scott AM, Furnari FB. PMID: 17363548.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    86. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res. 2006 Sep 01; 12(17):5064-73. Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, Gooding WE, Furnari FB, Grandis JR. PMID: 16951222.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    87. PCAF modulates PTEN activity. J Biol Chem. 2006 Sep 08; 281(36):26562-8. Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB. PMID: 16829519.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    88. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell. 2006 May; 9(5):379-90. Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA. PMID: 16697958.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    89. Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity. Clin Cancer Res. 2005 Sep 01; 11(17):6390-9. Perera RM, Narita Y, Furnari FB, Gan HK, Murone C, Ahlkvist M, Luwor RB, Burgess AW, Stockert E, Jungbluth AA, Old LJ, Cavenee WK, Scott AM, Johns TG. PMID: 16144944.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    90. PTEN: a novel anti-oncogenic function independent of phosphatase activity. . 2005 Apr; 4(4):540-2. Okumura K, Zhao M, DePinho RA, Furnari FB, Cavenee WK. PMID: 15753657.
      View in: PubMed   Mentions:
    91. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005 Apr 01; 18(1):13-24. Gao T, Furnari F, Newton AC. PMID: 15808505.
      View in: PubMed   Mentions: 347     Fields:    Translation:HumansCells
    92. Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2703-6. Okumura K, Zhao M, Depinho RA, Furnari FB, Cavenee WK. PMID: 15659546.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    93. Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol. 2004 10; 24(20):8981-93. Schmidt MHH, Hoeller D, Yu J, Furnari FB, Cavenee WK, Dikic I, Bögler O. PMID: 15456872.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    94. Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol. 2004 Jun 08; 14(11):942-52. Shah JV, Botvinick E, Bonday Z, Furnari F, Berns M, Cleveland DW. PMID: 15182667.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    95. Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma. Brain Tumor Pathol. 2004; 21(2):53-6. Nishikawa R, Sugiyama T, Narita Y, Furnari F, Cavenee WK, Matsutani M. PMID: 15700833.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    96. The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13418-23. Brentani H, Caballero OL, Camargo AA, da Silva AM, da Silva WA, Dias Neto E, Grivet M, Gruber A, Guimaraes PE, Hide W, Iseli C, Jongeneel CV, Kelso J, Nagai MA, Ojopi EP, Osorio EC, Reis EM, Riggins GJ, Simpson AJ, de Souza S, Stevenson BJ, Strausberg RL, Tajara EH, Verjovski-Almeida S, Acencio ML, Bengtson MH, Bettoni F, Bodmer WF, Briones MR, Camargo LP, Cavenee W, Cerutti JM, Coelho Andrade LE, Costa dos Santos PC, Ramos Costa MC, da Silva IT, Estécio MR, Sa Ferreira K, Furnari FB, Faria M, Galante PA, Guimaraes GS, Holanda AJ, Kimura ET, Leerkes MR, Lu X, Maciel RM, Martins EA, Massirer KB, Melo AS, Mestriner CA, Miracca EC, Miranda LL, Nobrega FG, Oliveira PS, Paquola AC, Pandolfi JR, Campos Pardini MI, Passetti F, Quackenbush J, Schnabel B, Sogayar MC, Souza JE, Valentini SR, Zaiats AC, Amaral EJ, Arnaldi LA, de Araújo AG, de Bessa SA, Bicknell DC, Ribeiro de Camaro ME, Carraro DM, Carrer H, Carvalho AF, Colin C, Costa F, Curcio C, Guerreiro da Silva ID, Pereira da Silva N, Dellamano M, El-Dorry H, Espreafico EM, Scattone Ferreira AJ, Ayres Ferreira C, Fortes MA, Gama AH, Giannella-Neto D, Giannella ML, Giorgi RR, Goldman GH, Goldman MH, Hackel C, Ho PL, Kimura EM, Kowalski LP, Krieger JE, Leite LC, Lopes A, Luna AM, Mackay A, Mari SK, Marques AA, Martins WK, Montagnini A, Mourão Neto M, Nascimento AL, Neville AM, Nobrega MP, O'Hare MJ, Otsuka AY, Ruas de Melo AI, Paco-Larson ML, Guimarães Pereira G, Pereira da Silva N, Pesquero JB, Pessoa JG, Rahal P, Rainho CA, Rodrigues V, Rogatto SR, Romano CM, Romeiro JG, Rossi BM, Rusticci M, Guerra de Sá R, Sant' Anna SC, Sarmazo ML, Silva TC, Soares FA, Sonati Mde F, de Freitas Sousa J, Queiroz D, Valente V, Vettore AL, Villanova FE, Zago MA, Zalcberg H. PMID: 14593198.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    97. Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. Proc Natl Acad Sci U S A. 2003 05 27; 100(11):6505-10. Schmidt MHH, Furnari FB, Cavenee WK, Bögler O. PMID: 12734385.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    98. Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. Cancer Res. 2002 Nov 15; 62(22):6764-9. Narita Y, Nagane M, Mishima K, Huang HJ, Furnari FB, Cavenee WK. PMID: 12438278.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    99. A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. J Neurochem. 2002 May; 81(3):575-88. De Smet C, Nishimori H, Furnari FB, Bögler O, Huang HJ, Cavenee WK. PMID: 12065666.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    100. The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor. J Biol Chem. 2001 Dec 07; 276(49):46313-8. Klingler-Hoffmann M, Fodero-Tavoletti MT, Mishima K, Narita Y, Cavenee WK, Furnari FB, Huang HJ, Tiganis T. PMID: 11514572.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    101. Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9936-41. Chuenkova MV, Furnari FB, Cavenee WK, Pereira MA. PMID: 11481434.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    102. Malignant glioma: genetics and biology of a grave matter. Genes Dev. 2001 Jun 01; 15(11):1311-33. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. PMID: 11390353.
      View in: PubMed   Mentions: 397     Fields:    Translation:HumansAnimals
    103. Non-isotopic silver-stained SSCP is more sensitive than automated direct sequencing for the detection of PTEN mutations in a mixture of DNA extracted from normal and tumor cells. Int J Oncol. 2001 May; 18(5):1023-6. Fan X, Furnari FB, Cavenee WK, Castresana JS. PMID: 11295051.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    104. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene. 2000 May 18; 19(22):2687-94. Reiss K, Wang JY, Romano G, Furnari FB, Cavenee WK, Morrione A, Tu X, Baserga R. PMID: 10851068.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    105. SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes. Neuro Oncol. 2000 01; 2(1):6-15. Bögler O, Furnari FB, Kindler-Roehrborn A, Sykes VW, Yung R, Huang HJ, Cavenee WK. PMID: 11302255.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    106. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. 1999 Jul 08; 18(27):3936-43. Wick W, Furnari FB, Naumann U, Cavenee WK, Weller M. PMID: 10435616.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    107. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res. 1998 Nov 15; 58(22):5002-8. Furnari FB, Huang HJ, Cavenee WK. PMID: 9823298.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansCells
    108. In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9418-23. Robertson GP, Furnari FB, Miele ME, Glendening MJ, Welch DR, Fountain JW, Lugo TG, Huang HJ, Cavenee WK. PMID: 9689095.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    109. Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. Cancer Res. 1998 Jul 01; 58(13):2724-6. Carethers JM, Furnari FB, Zigman AF, Lavine JE, Jones MC, Graham GE, Teebi AS, Huang HJ, Ha HT, Chauhan DP, Chang CL, Cavenee WK, Boland CR. PMID: 9661881.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    110. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12479-84. Furnari FB, Lin H, Huang HS, Cavenee WK. PMID: 9356475.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    111. Molecular biology of malignant degeneration of astrocytoma. Pediatr Neurosurg. 1996; 24(1):41-9. Furnari FB, Huang HJ, Cavenee WK. PMID: 8817614.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    112. Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res. 1995 May 01; 55(9):1941-5. Nishikawa R, Furnari FB, Lin H, Arap W, Berger MS, Cavenee WK, Su Huang HJ. PMID: 7728764.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    113. Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res. 1995 Mar 15; 55(6):1351-4. Arap W, Nishikawa R, Furnari FB, Cavenee WK, Huang HJ. PMID: 7882335.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    114. Genetics and malignant progression of human brain tumours. Cancer Surv. 1995; 25:233-75. Furnari FB, Huang HJ, Cavenee WK. PMID: 8718522.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    115. RAZ, an Epstein-Barr virus transdominant repressor that modulates the viral reactivation mechanism. J Virol. 1994 Mar; 68(3):1827-36. Furnari FB, Zacny V, Quinlivan EB, Kenney S, Pagano JS. PMID: 8107245.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    116. Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):378-82. Furnari FB, Adams MD, Pagano JS. PMID: 8093641.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    117. Regulation of the Epstein-Barr virus DNA polymerase gene. J Virol. 1992 May; 66(5):2837-45. Furnari FB, Adams MD, Pagano JS. PMID: 1313904.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
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