Frank Furnari

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Biophysical Interrogation of Signals that Drive GBM Invasion
    NIH R01NS116802May 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Genotypic Interactions in Brain Cancer Heterogeneity
    NIH/NINDS R01NS080939Sep 1, 2012 - Mar 31, 2023
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network. Life Sci Alliance. 2023 Aug; 6(8). Gerritsen JS, Faraguna JS, Bonavia R, Furnari FB, White FM. PMID: 37169593; PMCID: PMC10176108.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Cooperativity between H3.3K27M and PDGFRA poses multiple therapeutic vulnerabilities in human iPSC-derived diffuse midline glioma avatars. bioRxiv. 2023 Feb 24. Skinner KR, Koga T, Miki S, Gruener RF, Grigore FN, Torii EH, Seelig DM, Suzuki Y, Kawauchi D, Lin B, Malicki DM, Chen CC, Benveniste EN, Patel RP, McFarland BC, Huang RS, Jones C, Mackay A, Miller CR, Furnari FB. PMID: 36865329; PMCID: PMC9980117.
      View in: PubMed   Mentions:
    3. Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy. Cell Death Differ. 2023 02; 30(2):417-428. Contadini C, Ferri A, Di Martile M, Cirotti C, Del Bufalo D, De Nicola F, Pallocca M, Fanciulli M, Sacco F, Donninelli G, Capone A, Volpe E, Keller N, Miki S, Kawauchi D, Stupack D, Furnari F, Barilà D. PMID: 36460775; PMCID: PMC9950463.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. EGFR, the Lazarus target for precision oncology in glioblastoma. Neuro Oncol. 2022 Dec 01; 24(12):2035-2062. Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. PMID: 36125064; PMCID: PMC9713527.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo. Neuro Oncol. 2022 12 01; 24(12):2063-2075. Miki S, Koga T, Mckinney AM, Parisian AD, Tadokoro T, Vadla R, Marsala M, Hevner RF, Costello JF, Furnari F. PMID: 35325218; PMCID: PMC9713509.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Corrigendum to: EGFR, the Lazarus target for precision oncology in glioblastoma. Neuro Oncol. 2022 Nov 23. Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. PMID: 36416495.
      View in: PubMed   Mentions:    Fields:    
    7. PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors. Neuro Oncol. 2022 11 02; 24(11):1857-1868. Ferdosi SR, Taylor B, Lee M, Tang N, Peng S, Bybee R, Reid G, Hartman L, Garcia-Mansfield K, Sharma R, Pirrotte P, Ma J, Parisian AD, Furnari F, Dhruv HD, Berens ME. PMID: 35305088; PMCID: PMC9629460.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. The impact of phosphorylated PTEN at threonine 366 on cortical connectivity and behaviour. Brain. 2022 10 21; 145(10):3608-3621. Ledderose JMT, Benitez JA, Roberts AJ, Reed R, Bintig W, Larkum ME, Sachdev RNS, Furnari F, Eickholt BJ. PMID: 35603900.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. Cell Rep. 2021 11 02; 37(5):109957. Bi J, Khan A, Tang J, Armando AM, Wu S, Zhang W, Gimple RC, Reed A, Jing H, Koga T, Wong IT, Gu Y, Miki S, Yang H, Prager B, Curtis EJ, Wainwright DA, Furnari FB, Rich JN, Cloughesy TF, Kornblum HI, Quehenberger O, Rzhetsky A, Cravatt BF, Mischel PS. PMID: 34731610; PMCID: PMC8856626.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. PTEN deficiency leads to proteasome addiction: a novel vulnerability in glioblastoma. Neuro Oncol. 2021 07 01; 23(7):1072-1086. Benitez JA, Finlay D, Castanza A, Parisian AD, Ma J, Longobardi C, Campos A, Vadla R, Izurieta A, Scerra G, Koga T, Long T, Chavez L, Mesirov JP, Vuori K, Furnari F. PMID: 33428749; PMCID: PMC8661409.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. A Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas. Front Oncol. 2021; 11:652133. Jandrey EHF, Bezerra M, Inoue LT, Furnari FB, Camargo AA, Costa ÉT. PMID: 34178638; PMCID: PMC8222785.
      View in: PubMed   Mentions: 2  
    12. PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). Li J, Kaneda MM, Ma J, Li M, Shepard RM, Patel K, Koga T, Sarver A, Furnari F, Xu B, Dhawan S, Ning J, Zhu H, Wu A, You G, Jiang T, Venteicher AS, Rich JN, Glass CK, Varner JA, Chen CC. PMID: 33846242; PMCID: PMC8072253.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    13. Epidermal growth factor receptor as a molecular determinant of glioblastoma response to dopamine receptor D2 inhibitors. Neuro Oncol. 2021 03 25; 23(3):400-411. He Y, Li J, Koga T, Ma J, Dhawan S, Suzuki Y, Furnari F, Prabhu VV, Allen JE, Chen CC. PMID: 32830856; PMCID: PMC7992877.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Sci Adv. 2021 02; 7(7). Oatman N, Dasgupta N, Arora P, Choi K, Gawali MV, Gupta N, Parameswaran S, Salomone J, Reisz JA, Lawler S, Furnari F, Brennan C, Wu J, Sallans L, Gudelsky G, Desai P, Gebelein B, Weirauch MT, D'Alessandro A, Komurov K, Dasgupta B. PMID: 33568479; PMCID: PMC7875532.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    15. EGFRvIII uses intrinsic and extrinsic mechanisms to reduce glioma adhesion and increase migration. J Cell Sci. 2020 12 24; 133(24). Banisadr A, Eick M, Beri P, Parisian AD, Yeoman B, Placone JK, Engler AJ, Furnari F. PMID: 33243756; PMCID: PMC7774888.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability. Genes Dev. 2020 10 01; 34(19-20):1316-1329. Parisian AD, Koga T, Miki S, Johann PD, Kool M, Crawford JR, Furnari FB. PMID: 32912900; PMCID: PMC7528703.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    17. Genome Engineering Evolves Brain Tumor Modeling. Neurol Med Chir (Tokyo). 2020 Jul 15; 60(7):329-336. Koga T, Chen CC, Furnari FB. PMID: 32536682; PMCID: PMC7358782.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    18. Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas. EBioMedicine. 2020 May; 55:102736. Ramakrishnan V, Xu B, Akers J, Nguyen T, Ma J, Dhawan S, Ning J, Mao Y, Hua W, Kokkoli E, Furnari F, Carter BS, Chen CC. PMID: 32361246; PMCID: PMC7195524.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    19. Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020 04 20; 11(1):1958. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. PMID: 32312984; PMCID: PMC7171109.
      View in: PubMed   Mentions:    Fields:    
    20. Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020 Jan 28; 11(1):550. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. PMID: 31992716; PMCID: PMC6987220.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    21. Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy. Cell Rep. 2020 01 28; 30(4):969-983.e4. Wang S, Zhang Q, Tiwari SK, Lichinchi G, Yau EH, Hui H, Li W, Furnari F, Rana TM. PMID: 31956073; PMCID: PMC7293422.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    22. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 Dec 09; 36(6):690-691. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 31821785; PMCID: PMC6946119.
      View in: PubMed   Mentions: 7     Fields:    
    23. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019 11; 575(7784):699-703. Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. PMID: 31748743; PMCID: PMC7094777.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    24. Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins. Mol Cancer Res. 2019 11; 17(11):2208-2220. Jameson NM, Ma J, Benitez J, Izurieta A, Han JY, Mendez R, Parisian A, Furnari F. PMID: 31444232; PMCID: PMC6825583.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab. 2019 09 03; 30(3):525-538.e8. Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. PMID: 31303424; PMCID: PMC6742496.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    26. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 May 13; 35(5):816. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 31085179; PMCID: PMC8717880.
      View in: PubMed   Mentions: 10     Fields:    
    27. Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):10009-10018. Orellana L, Thorne AH, Lema R, Gustavsson J, Parisian AD, Hospital A, Cordeiro TN, Bernadó P, Scott AM, Brun-Heath I, Lindahl E, Cavenee WK, Furnari FB, Orozco M. PMID: 31028138; PMCID: PMC6525488.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    28. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. Nature. 2019 05; 569(7757):570-575. Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS. PMID: 31019297; PMCID: PMC7138021.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    29. When less is more: Gaining power through gene rearrangement of amplified EGFR. Oncotarget. 2019 Mar 15; 10(22):2116-2117. Koga T, Chen CC, Furnari FB. PMID: 31040904; PMCID: PMC6481334.
      View in: PubMed   Mentions: 1     Fields:    
    30. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 03 18; 35(3):504-518.e7. Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. PMID: 30827889; PMCID: PMC6424615.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    31. Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk. Cancer Res. 2019 03 15; 79(6):1239-1251. Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, Ljubimov VA, Shatalova ES, Wagner S, Li D, Mamelak AN, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Lyubimov AV, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY. PMID: 30659021; PMCID: PMC6625517.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    32. Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development. Neuro Oncol. 2018 09 03; 20(10):1310-1320. Koga T, Li B, Figueroa JM, Ren B, Chen CC, Carter BS, Furnari FB. PMID: 29660021; PMCID: PMC6120357.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    33. Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin. Autophagy. 2018; 14(10):1845-1846. Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 30118375; PMCID: PMC6135626.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    34. Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. Cancer Cell. 2018 07 09; 34(1):163-177.e7. Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM. PMID: 29990498; PMCID: PMC6424337.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    35. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596; PMCID: PMC6195840.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    36. Publisher Correction: PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2018 05 25; 9:16217. Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB. PMID: 29799523; PMCID: PMC6026911.
      View in: PubMed   Mentions: 1     Fields:    
    37. MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5768-5773. Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB. PMID: 29760085; PMCID: PMC5984507.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    38. Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts. J Vis Exp. 2018 04 26; (134). Benitez JA, Zanca C, Ma J, Cavenee WK, Furnari FB. PMID: 29757276; PMCID: PMC6100979.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    39. FHL2 interacts with EGFR to promote glioblastoma growth. Oncogene. 2018 03; 37(10):1386-1398. Sun L, Yu S, Xu H, Zheng Y, Lin J, Wu M, Wang J, Wang A, Lan Q, Furnari F, Cavenee W, Purow B, Li M. PMID: 29321665; PMCID: PMC8691187.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    40. Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity. Genes Dev. 2017 06 15; 31(12):1212-1227. Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee WK, Furnari FB. PMID: 28724615; PMCID: PMC5558924.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    41. PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2017 05 12; 8:15223. Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee WK, Furnari FB. PMID: 28497778; PMCID: PMC5437297.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    42. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237; PMCID: PMC5334176.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansCells
    43. Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proc Natl Acad Sci U S A. 2017 01 10; 114(2):370-375. Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, Hu B, Emdad L, Valerie K, Sarkar D, Furnari FB, Cavenee WK, Wei J, Purves A, De SK, Pellecchia M, Fisher PB. PMID: 28011764; PMCID: PMC5240699.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    44. Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme. J Control Release. 2016 12 28; 244(Pt A):14-23. Chou ST, Patil R, Galstyan A, Gangalum PR, Cavenee WK, Furnari FB, Ljubimov VA, Chesnokova A, Kramerov AA, Ding H, Falahatian V, Mashouf L, Fox I, Black KL, Holler E, Ljubimov AV, Ljubimova JY. PMID: 27825958; PMCID: PMC5308909.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    45. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. 2016 Nov 14; 30(5):683-693. Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. PMID: 27746144; PMCID: PMC5479636.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    46. The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-). Cancer Res. 2016 05 15; 76(10):2954-63. Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H, Nagano O. PMID: 26980765; PMCID: PMC4873328.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    47. Epidermal growth factor receptor targeting and challenges in glioblastoma. Neuro Oncol. 2016 07; 18(7):914-8. Thorne AH, Zanca C, Furnari F. PMID: 26755074; PMCID: PMC4896544.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    48. EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. Mol Cell. 2015 Oct 15; 60(2):307-18. Liu F, Hon GC, Villa GR, Turner KM, Ikegami S, Yang H, Ye Z, Li B, Kuan S, Lee AY, Zanca C, Wei B, Lucey G, Jenkins D, Zhang W, Barr CL, Furnari FB, Cloughesy TF, Yong WH, Gahman TC, Shiau AK, Cavenee WK, Ren B, Mischel PS. PMID: 26455392; PMCID: PMC4609298.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    49. Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition. Oncotarget. 2015 May 20; 6(14):11751-67. Shen Y, Li J, Nitta M, Futalan D, Steed T, Treiber JM, Taich Z, Stevens D, Wykosky J, Chen HZ, Carter BS, Becher OJ, Kennedy R, Esashi F, Sarkaria JN, Furnari FB, Cavenee WK, Desai A, Chen CC. PMID: 26059434; PMCID: PMC4494902.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    50. Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma. Nat Rev Cancer. 2015 May; 15(5):302-10. Furnari FB, Cloughesy TF, Cavenee WK, Mischel PS. PMID: 25855404; PMCID: PMC4875778.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansCells
    51. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29; 160(3):489-502. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. PMID: 25619690; PMCID: PMC4313737.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
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    105. Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma. Brain Tumor Pathol. 2004; 21(2):53-6. Nishikawa R, Sugiyama T, Narita Y, Furnari F, Cavenee WK, Matsutani M. PMID: 15700833.
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    106. The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13418-23. Brentani H, Caballero OL, Camargo AA, da Silva AM, da Silva WA, Dias Neto E, Grivet M, Gruber A, Guimaraes PE, Hide W, Iseli C, Jongeneel CV, Kelso J, Nagai MA, Ojopi EP, Osorio EC, Reis EM, Riggins GJ, Simpson AJ, de Souza S, Stevenson BJ, Strausberg RL, Tajara EH, Verjovski-Almeida S, Acencio ML, Bengtson MH, Bettoni F, Bodmer WF, Briones MR, Camargo LP, Cavenee W, Cerutti JM, Coelho Andrade LE, Costa dos Santos PC, Ramos Costa MC, da Silva IT, Estécio MR, Sa Ferreira K, Furnari FB, Faria M, Galante PA, Guimaraes GS, Holanda AJ, Kimura ET, Leerkes MR, Lu X, Maciel RM, Martins EA, Massirer KB, Melo AS, Mestriner CA, Miracca EC, Miranda LL, Nobrega FG, Oliveira PS, Paquola AC, Pandolfi JR, Campos Pardini MI, Passetti F, Quackenbush J, Schnabel B, Sogayar MC, Souza JE, Valentini SR, Zaiats AC, Amaral EJ, Arnaldi LA, de Araújo AG, de Bessa SA, Bicknell DC, Ribeiro de Camaro ME, Carraro DM, Carrer H, Carvalho AF, Colin C, Costa F, Curcio C, Guerreiro da Silva ID, Pereira da Silva N, Dellamano M, El-Dorry H, Espreafico EM, Scattone Ferreira AJ, Ayres Ferreira C, Fortes MA, Gama AH, Giannella-Neto D, Giannella ML, Giorgi RR, Goldman GH, Goldman MH, Hackel C, Ho PL, Kimura EM, Kowalski LP, Krieger JE, Leite LC, Lopes A, Luna AM, Mackay A, Mari SK, Marques AA, Martins WK, Montagnini A, Mourão Neto M, Nascimento AL, Neville AM, Nobrega MP, O'Hare MJ, Otsuka AY, Ruas de Melo AI, Paco-Larson ML, Guimarães Pereira G, Pereira da Silva N, Pesquero JB, Pessoa JG, Rahal P, Rainho CA, Rodrigues V, Rogatto SR, Romano CM, Romeiro JG, Rossi BM, Rusticci M, Guerra de Sá R, Sant' Anna SC, Sarmazo ML, Silva TC, Soares FA, Sonati Mde F, de Freitas Sousa J, Queiroz D, Valente V, Vettore AL, Villanova FE, Zago MA, Zalcberg H, Human Cancer Genome Project/Cancer Genome Anatomy Project Annotation Consortium, Human Cancer Genome Project Sequencing Consortium. PMID: 14593198; PMCID: PMC263829.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    107. Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. Proc Natl Acad Sci U S A. 2003 05 27; 100(11):6505-10. Schmidt MHH, Furnari FB, Cavenee WK, Bögler O. PMID: 12734385; PMCID: PMC164476.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    108. Non-isotopic silver-stained SSCP is more sensitive than automated direct sequencing for the detection of PTEN mutations in a mixture of DNA extracted from normal and tumor cells. Int J Oncol. 2001 May; 18(5):1023-6. Fan X, Furnari FB, Cavenee WK, Castresana JS. PMID: 11295051.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    109. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation. Oncogene. 2000 May 18; 19(22):2687-94. Reiss K, Wang JY, Romano G, Furnari FB, Cavenee WK, Morrione A, Tu X, Baserga R. PMID: 10851068.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    110. SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes. Neuro Oncol. 2000 01; 2(1):6-15. Bögler O, Furnari FB, Kindler-Roehrborn A, Sykes VW, Yung R, Huang HJ, Cavenee WK. PMID: 11302255; PMCID: PMC1920697.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    111. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. 1999 Jul 08; 18(27):3936-43. Wick W, Furnari FB, Naumann U, Cavenee WK, Weller M. PMID: 10435616.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    112. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer Res. 1998 Nov 15; 58(22):5002-8. Furnari FB, Huang HJ, Cavenee WK. PMID: 9823298.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    113. In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9418-23. Robertson GP, Furnari FB, Miele ME, Glendening MJ, Welch DR, Fountain JW, Lugo TG, Huang HJ, Cavenee WK. PMID: 9689095; PMCID: PMC21353.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    114. Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. Cancer Res. 1998 Jul 01; 58(13):2724-6. Carethers JM, Furnari FB, Zigman AF, Lavine JE, Jones MC, Graham GE, Teebi AS, Huang HJ, Ha HT, Chauhan DP, Chang CL, Cavenee WK, Boland CR. PMID: 9661881.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    115. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12479-84. Furnari FB, Lin H, Huang HS, Cavenee WK. PMID: 9356475; PMCID: PMC25009.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansCells
    116. Molecular biology of malignant degeneration of astrocytoma. Pediatr Neurosurg. 1996; 24(1):41-9. Furnari FB, Huang HJ, Cavenee WK. PMID: 8817614.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    117. Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res. 1995 May 01; 55(9):1941-5. Nishikawa R, Furnari FB, Lin H, Arap W, Berger MS, Cavenee WK, Su Huang HJ. PMID: 7728764.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    118. Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res. 1995 Mar 15; 55(6):1351-4. Arap W, Nishikawa R, Furnari FB, Cavenee WK, Huang HJ. PMID: 7882335.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    119. Genetics and malignant progression of human brain tumours. Cancer Surv. 1995; 25:233-75. Furnari FB, Huang HJ, Cavenee WK. PMID: 8718522.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    120. RAZ, an Epstein-Barr virus transdominant repressor that modulates the viral reactivation mechanism. J Virol. 1994 Mar; 68(3):1827-36. Furnari FB, Zacny V, Quinlivan EB, Kenney S, Pagano JS. PMID: 8107245; PMCID: PMC236645.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    121. Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):378-82. Furnari FB, Adams MD, Pagano JS. PMID: 8093641; PMCID: PMC45665.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    122. Regulation of the Epstein-Barr virus DNA polymerase gene. J Virol. 1992 May; 66(5):2837-45. Furnari FB, Adams MD, Pagano JS. PMID: 1313904; PMCID: PMC241041.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
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