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    Barbara Parker

    TitleProfessor Of Clinical
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0987
    CA La Jolla 92093
    Phone858-822-6135
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      Research Interests
      My research interests include personalized approaches to cancer screening and prevention, new therapies on genomic profiling and breast cancer survivorship issues. I served as the Medical Director of the WHEL Diet Study. I currently serve as the CALGB/Alliance/ACTION clinical trials UCSD Principal Investigator and serve on the CALGB/Alliance Breast Committee and the CALGB/Alliance Prevention Committee. I serve as site PI and Co-Chair of the Diagnosis and Treatment Clinical Care and Research Group of the California Athena Breast Health Network, co-investigator of studies of life-style modification in breast cancer survivors, and co-investigator of studies involving new agents. My clinical practice is comprised of breast cancer patients.

      Education and Training
      BA - Chemistry - University of North Carolina at Chapel Hill, NC - 1974
      MD - Medicine - Stanford University of Medicine, CA - 1981
      Intern/Resident - Medicine - UC San Diego Department of Medicine, CA - 1982-1984
      Chief Resident - Medicine - UC San Diego Department of Medicine, CA - 1985
      Fellowship - Hematology/Oncology - UC San Diego Department of Medicine, CA - 1987


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bieg-Bourne CC, Millis SZ, Piccioni DE, Fanta PT, Goldberg ME, Chmielecki J, Parker B, Kurzrock R. Next-generation sequencing in the clinical setting clarifies patient characteristics and potential actionability. Cancer Res. 2017 Sep 22. PMID: 28939679.
        View in: PubMed
      2. Hartman SJ, Nelson SH, Myers E, Natarajan L, Sears DD, Palmer BW, Weiner LS, Parker B, Patterson RE. Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer. 2017 Sep 19. PMID: 28926676.
        View in: PubMed
      3. Hartman SJ, Nelson SH, Cadmus-Bertram LA, Patterson RE, Parker B, Pierce JP. Technology- and Phone-Based Weight Loss Intervention: Pilot RCT in Women at Elevated Breast Cancer Risk. Am J Prev Med. 2016 Nov; 51(5):714-721. PMID: 27593420.
        View in: PubMed
      4. Nardi EA, Wolfson JA, Rosen ST, Diasio RB, Gerson SL, Parker B, Alvarnas JC, Levine HA, Fong Y, Weisenburger DD, Fitzgerald CL, Egan M, Stranford S, Carlson RW, Benz EJ. Value, Access, and Cost of Cancer Care Delivery at Academic Cancer Centers. J Natl Compr Canc Netw. 2016 Jul; 14(7):837-47. PMID: 27407124.
        View in: PubMed
      5. Schwaederle M, Husain H, Fanta PT, Piccioni DE, Kesari S, Schwab RB, Patel SP, Harismendy O, Ikeda M, Parker B, Kurzrock R. Use of Liquid Biopsies in Clinical Oncology: Pilot Experience in 168 Patients. Clin Cancer Res. 2016 Nov 15; 22(22):5497-5505. PMID: 27185373.
        View in: PubMed
      6. Parker B, Pierce JP. Importance of Smoking Cessation to Reduce Breast Cancer Mortality. J Clin Oncol. 2016 Apr 20; 34(12):1295-6. PMID: 26951316.
        View in: PubMed
      7. Schwaederle M, Husain H, Fanta PT, Piccioni DE, Kesari S, Schwab RB, Banks KC, Lanman RB, Talasaz A, Parker B, Kurzrock R. Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay. Oncotarget. 2016 Mar 01; 7(9):9707-17. PMID: 26848768; PMCID: PMC4891078.
      8. Schwaederle M, Parker B, Schwab RB, Daniels GA, Piccioni DE, Kesari S, Helsten TL, Bazhenova LA, Romero J, Fanta PT, Lippman SM, Kurzrock R. Precision Oncology: The UC San Diego Moores Cancer Center PREDICT Experience. Mol Cancer Ther. 2016 Apr; 15(4):743-52. PMID: 26873727.
        View in: PubMed
      9. Patterson RE, Marinac CR, Natarajan L, Hartman SJ, Cadmus-Bertram L, Flatt SW, Li H, Parker B, Oratowski-Coleman J, Villaseñor A, Godbole S, Kerr J. Recruitment strategies, design, and participant characteristics in a trial of weight-loss and metformin in breast cancer survivors. Contemp Clin Trials. 2016 Mar; 47:64-71. PMID: 26706665; PMCID: PMC4818156 [Available on 03/01/17].
      10. Bao L, Messer K, Schwab R, Harismendy O, Pu M, Crain B, Yost S, Frazer KA, Rana B, Hasteh F, Wallace A, Parker B. Mutational Profiling Can Establish Clonal or Independent Origin in Synchronous Bilateral Breast and Other Tumors. PLoS One. 2015; 10(11):e0142487. PMID: 26554380; PMCID: PMC4640562.
      11. Patel SP, Schwaederle M, Daniels GA, Fanta PT, Schwab RB, Shimabukuro KA, Kesari S, Piccioni DE, Bazhenova LA, Helsten TL, Lippman SM, Parker B, Kurzrock R. Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology. Oncotarget. 2015 Oct 20; 6(32):32602-9. PMID: 26418953; PMCID: PMC4741715.
      12. Hartman SJ, Natarajan L, Palmer BW, Parker B, Patterson RE, Sears DD. Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion. Contemp Clin Trials. 2015 Nov; 45(Pt B):371-376. PMID: 26427563; PMCID: PMC4674350 [Available on 11/01/16].
      13. Rock CL, Flatt SW, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY, Elias A, Krontiras H, Liu J, Naughton M, Pakiz B, Parker B, Sedjo RL, Wyatt H. Results of the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial: A Behavioral Weight Loss Intervention in Overweight or Obese Breast Cancer Survivors. J Clin Oncol. 2015 Oct 01; 33(28):3169-76. PMID: 26282657; PMCID: PMC4582146 [Available on 10/01/16].
      14. Schwab RB, Kato S, Crain B, Pu M, Messer K, Weidner N, Blair SL, Wallace AM, Carson DA, Parker B. A window-of-opportunity biomarker study of etodolac in resectable breast cancer. Cancer Med. 2015 Oct; 4(10):1583-8. PMID: 26275572; PMCID: PMC4618628.
      15. Parker B, Schwaederlé M, Scur MD, Boles SG, Helsten T, Subramanian R, Schwab RB, Kurzrock R. Breast Cancer Experience of the Molecular Tumor Board at the University of California, San Diego Moores Cancer Center. J Oncol Pract. 2015 Nov; 11(6):442-9. PMID: 26243651.
        View in: PubMed
      16. Schwaederle M, Daniels GA, Piccioni DE, Fanta PT, Schwab RB, Shimabukuro KA, Parker B, Kurzrock R. On the Road to Precision Cancer Medicine: Analysis of Genomic Biomarker Actionability in 439 Patients. Mol Cancer Ther. 2015 Jun; 14(6):1488-94. PMID: 25852059.
        View in: PubMed
      17. Schwaederlé M, Daniels GA, Piccioni DE, Fanta PT, Schwab RB, Shimabukuro KA, Parker B, Kurzrock R. Cyclin alterations in diverse cancers: Outcome and co-amplification network. Oncotarget. 2015 Feb 20; 6(5):3033-42. PMID: 25596748; PMCID: PMC4413635.
      18. Kato S, Schwaederle M, Daniels GA, Piccioni D, Kesari S, Bazhenova L, Shimabukuro K, Parker B, Fanta P, Kurzrock R. Cyclin-dependent kinase pathway aberrations in diverse malignancies: clinical and molecular characteristics. Cell Cycle. 2015; 14(8):1252-9. PMID: 25695927; PMCID: PMC4614867.
      19. Schwaederle M, Daniels GA, Piccioni DE, Kesari S, Fanta PT, Schwab RB, Shimabukuro KA, Parker B, Kurzrock R. Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer. Cell Cycle. 2015; 14(11):1730-7. PMID: 25928476; PMCID: PMC4614790.
      20. Scott BJ, van Vugt VA, Rush T, Brown T, Chen CC, Carter BS, Schwab R, Fanta P, Helsten T, Bazhenova L, Parker B, Pingle S, Saria MG, Brown BD, Piccioni DE, Kesari S. Concurrent intrathecal methotrexate and liposomal cytarabine for leptomeningeal metastasis from solid tumors: a retrospective cohort study. J Neurooncol. 2014 Sep; 119(2):361-8. PMID: 24942463.
        View in: PubMed
      21. Wheler JJ, Parker B, Lee JJ, Atkins JT, Janku F, Tsimberidou AM, Zinner R, Subbiah V, Fu S, Schwab R, Moulder S, Valero V, Schwaederle M, Yelensky R, Miller VA, Stephens MP, Meric-Bernstam F, Kurzrock R. Unique molecular signatures as a hallmark of patients with metastatic breast cancer: implications for current treatment paradigms. Oncotarget. 2014 May 15; 5(9):2349-54. PMID: 24811890; PMCID: PMC4058010.
      22. Schwaederle M, Parker B, Schwab RB, Fanta PT, Boles SG, Daniels GA, Bazhenova LA, Subramanian R, Coutinho AC, Ojeda-Fournier H, Datnow B, Webster NJ, Lippman SM, Kurzrock R. Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 2014 Jun; 19(6):631-6. PMID: 24797821; PMCID: PMC4041669.
      23. Ancoli-Israel S, Liu L, Rissling M, Natarajan L, Neikrug AB, Palmer BW, Mills PJ, Parker B, Sadler GR, Maglione J. Sleep, fatigue, depression, and circadian activity rhythms in women with breast cancer before and after treatment: a 1-year longitudinal study. Support Care Cancer. 2014 Sep; 22(9):2535-45. PMID: 24733634; PMCID: PMC4119484.
      24. Yan M, Parker B, Schwab R, Kurzrock R. HER2 aberrations in cancer: implications for therapy. Cancer Treat Rev. 2014 Jul; 40(6):770-80. PMID: 24656976.
        View in: PubMed
      25. Harismendy O, Schwab RB, Alakus H, Yost SE, Matsui H, Hasteh F, Wallace AM, Park HL, Madlensky L, Parker B, Carpenter PM, Jepsen K, Anton-Culver H, Frazer KA. Evaluation of ultra-deep targeted sequencing for personalized breast cancer care. Breast Cancer Res. 2013 Dec 10; 15(6):R115. PMID: 24326041; PMCID: PMC3978701.
      26. Rock CL, Pande C, Flatt SW, Ying C, Pakiz B, Parker B, Williams K, Bardwell WA, Heath DD, Nichols JF. Favorable changes in serum estrogens and other biologic factors after weight loss in breast cancer survivors who are overweight or obese. Clin Breast Cancer. 2013 Jun; 13(3):188-95. PMID: 23375717; PMCID: PMC4153749.
      27. Liu L, Rissling M, Neikrug A, Fiorentino L, Natarajan L, Faierman M, Sadler GR, Dimsdale JE, Mills PJ, Parker B, Ancoli-Israel S. Fatigue and Circadian Activity Rhythms in Breast Cancer Patients Before and After Chemotherapy: A Controlled Study. Fatigue. 2013; 1(1-2):12-26. PMID: 23412418.
        View in: PubMed
      28. Rock CL, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY, Elias A, Krontiras H, Liu J, Naughton M, Pakiz B, Parker B, Sedjo RL, Wyatt H. Reducing breast cancer recurrence with weight loss, a vanguard trial: the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial. Contemp Clin Trials. 2013 Mar; 34(2):282-95. PMID: 23266440; PMCID: PMC3593786.
      29. Cadmus-Bertram L, Wang JB, Patterson RE, Newman VA, Parker B, Pierce JP. Web-based self-monitoring for weight loss among overweight/obese women at increased risk for breast cancer: the HELP pilot study. Psychooncology. 2013 Aug; 22(8):1821-8. PMID: 23188655.
        View in: PubMed
      30. Jeste N, Liu L, Rissling M, Trofimenko V, Natarajan L, Parker B, Ancoli-Israel S. Prevention of quality-of-life deterioration with light therapy is associated with changes in fatigue in women with breast cancer undergoing chemotherapy. Qual Life Res. 2013 Aug; 22(6):1239-44. PMID: 22865153; PMCID: PMC3780416.
      31. Saquib J, Parker B, Natarajan L, Madlensky L, Saquib N, Patterson RE, Newman VA, Pierce JP. Prognosis following the use of complementary and alternative medicine in women diagnosed with breast cancer. Complement Ther Med. 2012 Oct; 20(5):283-90. PMID: 22863642; PMCID: PMC3413169.
      32. Yost SE, Smith EN, Schwab RB, Bao L, Jung H, Wang X, Voest E, Pierce JP, Messer K, Parker B, Harismendy O, Frazer KA. Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens. Nucleic Acids Res. 2012 Aug; 40(14):e107. PMID: 22492626; PMCID: PMC3413110.
      33. Liu L, Mills PJ, Rissling M, Fiorentino L, Natarajan L, Dimsdale JE, Sadler GR, Parker B, Ancoli-Israel S. Fatigue and sleep quality are associated with changes in inflammatory markers in breast cancer patients undergoing chemotherapy. Brain Behav Immun. 2012 Jul; 26(5):706-13. PMID: 22406004; PMCID: PMC3372667.
      34. Liu L, Rissling M, Natarajan L, Fiorentino L, Mills PJ, Dimsdale JE, Sadler GR, Parker B, Ancoli-Israel S. The longitudinal relationship between fatigue and sleep in breast cancer patients undergoing chemotherapy. Sleep. 2012 Feb 01; 35(2):237-45. PMID: 22294814; PMCID: PMC3250363.
      35. Neikrug AB, Rissling M, Trofimenko V, Liu L, Natarajan L, Lawton S, Parker B, Ancoli-Israel S. Bright light therapy protects women from circadian rhythm desynchronization during chemotherapy for breast cancer. Behav Sleep Med. 2012; 10(3):202-16. PMID: 22742438.
        View in: PubMed
      36. Ancoli-Israel S, Rissling M, Neikrug A, Trofimenko V, Natarajan L, Parker B, Lawton S, Desan P, Liu L. Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer. Support Care Cancer. 2012 Jun; 20(6):1211-9. PMID: 21660669; PMCID: PMC3192914.
      37. Al-Delaimy WK, Flatt SW, Natarajan L, Laughlin GA, Rock CL, Gold EB, Caan BJ, Parker B, Pierce JP. IGF1 and risk of additional breast cancer in the WHEL study. Endocr Relat Cancer. 2011 Apr; 18(2):235-44. PMID: 21263044.
        View in: PubMed
      38. Saquib N, Pierce JP, Saquib J, Flatt SW, Natarajan L, Bardwell WA, Patterson RE, Stefanick ML, Thomson CA, Rock CL, Jones LA, Gold EB, Karanja N, Parker B. Poor physical health predicts time to additional breast cancer events and mortality in breast cancer survivors. Psychooncology. 2011 Mar; 20(3):252-9. PMID: 20878837; PMCID: PMC3297415.
      39. Patterson RE, Flatt SW, Newman VA, Natarajan L, Rock CL, Thomson CA, Caan BJ, Parker B, Pierce JP. Marine fatty acid intake is associated with breast cancer prognosis. J Nutr. 2011 Feb; 141(2):201-6. PMID: 21178081; PMCID: PMC3021439.
      40. Erickson K, Patterson RE, Flatt SW, Natarajan L, Parker B, Heath DD, Laughlin GA, Saquib N, Rock CL, Pierce JP. Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. J Clin Oncol. 2011 Jan 01; 29(1):54-60. PMID: 21115861; PMCID: PMC3055860.
      41. Patterson RE, Saquib N, Natarajan L, Rock CL, Parker B, Thomson CA, Pierce JP. Improvement in self-reported physical health predicts longer survival among women with a history of breast cancer. Breast Cancer Res Treat. 2011 Jun; 127(2):541-7. PMID: 21042931; PMCID: PMC3306248.
      42. Gorman JR, Roesch SC, Parker B, Madlensky L, Saquib N, Newman VA, Pierce JP. Physical and mental health correlates of pregnancy following breast cancer. Psychooncology. 2010 May; 19(5):517-24. PMID: 20425779; PMCID: PMC2861788.
      43. Patterson RE, Flatt SW, Saquib N, Rock CL, Caan BJ, Parker B, Laughlin GA, Erickson K, Thomson CA, Bardwell WA, Hajek RA, Pierce JP. Medical comorbidities predict mortality in women with a history of early stage breast cancer. Breast Cancer Res Treat. 2010 Aug; 122(3):859-65. PMID: 20077000; PMCID: PMC2895945.
      44. Natarajan L, Pu M, Parker B, Thomson CA, Caan BJ, Flatt SW, Madlensky L, Hajek RA, Al-Delaimy WK, Saquib N, Gold EB, Pierce JP. Time-varying effects of prognostic factors associated with disease-free survival in breast cancer. Am J Epidemiol. 2009 Jun 15; 169(12):1463-70. PMID: 19403844; PMCID: PMC2733768.
      45. Pierce JP, Natarajan L, Caan BJ, Flatt SW, Kealey S, Gold EB, Hajek RA, Newman VA, Rock CL, Pu M, Saquib N, Stefanick ML, Thomson CA, Parker B. Dietary change and reduced breast cancer events among women without hot flashes after treatment of early-stage breast cancer: subgroup analysis of the Women's Healthy Eating and Living Study. Am J Clin Nutr. 2009 May; 89(5):1565S-1571S. PMID: 19339393; PMCID: PMC2677006.
      46. Liu L, Fiorentino L, Natarajan L, Parker B, Mills PJ, Sadler GR, Dimsdale JE, Rissling M, He F, Ancoli-Israel S. Pre-treatment symptom cluster in breast cancer patients is associated with worse sleep, fatigue and depression during chemotherapy. Psychooncology. 2009 Feb; 18(2):187-94. PMID: 18677716; PMCID: PMC2762479.
      47. Pierce JP, Newman VA, Natarajan L, Flatt SW, Al-Delaimy WK, Caan BJ, Emond JA, Faerber S, Gold EB, Hajek RA, Hollenbach K, Jones LA, Karanja N, Kealey S, Madlensky L, Marshall J, Ritenbaugh C, Rock CL, Stefanick ML, Thomson C, Wasserman L, Parker B. Telephone counseling helps maintain long-term adherence to a high-vegetable dietary pattern. J Nutr. 2007 Oct; 137(10):2291-6. PMID: 17885013; PMCID: PMC2064909.
      48. Pierce JP, Natarajan L, Caan BJ, Parker B, Greenberg ER, Flatt SW, Rock CL, Kealey S, Al-Delaimy WK, Bardwell WA, Carlson RW, Emond JA, Faerber S, Gold EB, Hajek RA, Hollenbach K, Jones LA, Karanja N, Madlensky L, Marshall J, Newman VA, Ritenbaugh C, Thomson CA, Wasserman L, Stefanick ML. Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial. JAMA. 2007 Jul 18; 298(3):289-98. PMID: 17635889; PMCID: PMC2083253.
      49. Pierce JP, Stefanick ML, Flatt SW, Natarajan L, Sternfeld B, Madlensky L, Al-Delaimy WK, Thomson CA, Kealey S, Hajek R, Parker B, Newman VA, Caan B, Rock CL. Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity. J Clin Oncol. 2007 Jun 10; 25(17):2345-51. PMID: 17557947; PMCID: PMC2274898.
      50. Mortimer JE, Flatt SW, Parker B, Gold EB, Wasserman L, Natarajan L, Pierce JP. Tamoxifen, hot flashes and recurrence in breast cancer. Breast Cancer Res Treat. 2008 Apr; 108(3):421-6. PMID: 17541741; PMCID: PMC2575100.
      51. Ancoli-Israel S, Liu L, Marler MR, Parker B, Jones V, Sadler GR, Dimsdale J, Cohen-Zion M, Fiorentino L. Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer. Support Care Cancer. 2006 Mar; 14(3):201-9. PMID: 16010529; PMCID: PMC1599708.
      52. Liu L, Marler MR, Parker B, Jones V, Johnson S, Cohen-Zion M, Fiorentino L, Sadler GR, Ancoli-Israel S. The relationship between fatigue and light exposure during chemotherapy. Support Care Cancer. 2005 Dec; 13(12):1010-7. PMID: 15864659; PMCID: PMC1599705.