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    Samuel Rapaport

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #9111
    CA La Jolla 92093
    Phone858-454-2914
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      Collapse Research Activities and Funding
      HEMATOLOGY STUDY SECTION
      NIH/CSR U09RG010773Oct 1, 1985 - Jun 30, 1991
      Role: Co-Principal Investigator
      RELATIONSHIPS BETWEEN COAGULATION AND THROMBOSIS
      NIH/NHLBI R37HL027234May 1, 1981 - Apr 30, 1997
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Rapaport S, Vermylen J, Hoylaerts M, Saito H, Hirsh J, Bates S, Dahlbäck B, Poller L. The multiple faces of the partial thromboplastin time APTT. J Thromb Haemost. 2004 Dec; 2(12):2250-9. PMID: 15613038.
        View in: PubMed
      2. Rapaport S. Coagulation problems in liver disease. Blood Coagul Fibrinolysis. 2000 Apr; 11 Suppl 1:S69-74. PMID: 10850568.
        View in: PubMed
      3. Petrovan RJ, Rapaport S, Le DT. A novel clotting assay for quantitation of plasma prothrombin (factor II) using Echis multisquamatus venom. Am J Clin Pathol. 1999 Nov; 112(5):705-11. PMID: 10549258.
        View in: PubMed
      4. Le DT, Borgs P, Toneff TW, Witte MH, Rapaport S. Hemostatic factors in rabbit limb lymph: relationship to mechanisms regulating extravascular coagulation. Am J Physiol. 1998 Mar; 274(3 Pt 2):H769-76. PMID: 9530187.
        View in: PubMed
      5. Rapaport S. Presentation of the 1997 George M. Kober Medal to Helen Ranney. Proc Assoc Am Physicians. 1997 Sep; 109(5):494-503. PMID: 9285948.
        View in: PubMed
      6. Gable PS, Le DT, McGehee W, Rapaport S. A Protac-based screening test for activated protein C-resistant factor Va and other defects of the protein C anticoagulant pathway. Blood Coagul Fibrinolysis. 1997 Sep; 8(6):327-35. PMID: 9351522.
        View in: PubMed
      7. Weibert RT, Le DT, Kayser SR, Rapaport S. Correction of excessive anticoagulation with low-dose oral vitamin K1. Ann Intern Med. 1997 Jun 15; 126(12):959-62. PMID: 9182473.
        View in: PubMed
      8. Gable PS, Le DT, Rapaport S. Protac, a commercially available protein C activator from the venom of Agkistrodon contortrix contortrix, can activate factor V and factor VIII. Thromb Res. 1997 Apr 1; 86(1):79-84. PMID: 9172290.
        View in: PubMed
      9. Le DT, Donnelly KJ, Wu N, Sevilla BK, Rapaport S. Reliability of a modified tissue factor-dependent factor V assay for activated protein C resistant factor Va using a calcium-containing thromboplastin. Thromb Haemost. 1997 Mar; 77(3):481-5. PMID: 9065998.
        View in: PubMed
      10. Rapaport S, Toneff T, Rimon A, Warn-Cramer BJ. The effect of immunodepletion of antithrombin III on the response of rabbits to Russell's viper venom-induced activation of factor X. Arterioscler Thromb Vasc Biol. 1997 Feb; 17(2):409-16. PMID: 9081698.
        View in: PubMed
      11. Zivelin A, Rao LV, Rapaport S. Plasma PIVKA proteins in rabbits given warfarin. Thromb Res. 1996 Jun 1; 82(5):429-38. PMID: 8771703.
        View in: PubMed
      12. Rapaport S, Rao LV. The tissue factor pathway: how it has become a "prima ballerina". Thromb Haemost. 1995 Jul; 74(1):7-17. PMID: 8578528.
        View in: PubMed
      13. Le DT, Griffin JH, Greengard JS, Mujumdar V, Rapaport S. Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant. Blood. 1995 Apr 1; 85(7):1704-11. PMID: 7703480.
        View in: PubMed
      14. Warn-Cramer BJ, Rapaport S. Evidence suggestive of activation of the intrinsic pathway of blood coagulation after injection of factor Xa/phospholipid into rabbits. Arterioscler Thromb Vasc Biol. 1995 Jan; 15(1):133-9. PMID: 7749809.
        View in: PubMed
      15. Zivelin A, Rao LV, Rapaport S. Evidence for an essential role of tissue factor dependent blood coagulation in the pathogenesis of the local Shwartzman reaction. Blood Cells Mol Dis. 1995; 21(1):9-19. PMID: 7655863.
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      16. Le DT, Rapaport S, Rao LV. Studies of the mechanism for enhanced cell surface factor VIIa/tissue factor activation of factor X on fibroblast monolayers after their exposure to N-ethylmaleimide. Thromb Haemost. 1994 Dec; 72(6):848-55. PMID: 7740453.
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      17. Permpikul P, Rao LV, Rapaport S. Functional and binding studies of the roles of prothrombin and beta 2-glycoprotein I in the expression of lupus anticoagulant activity. Blood. 1994 May 15; 83(10):2878-92. PMID: 8180383.
        View in: PubMed
      18. Le DT, Weibert RT, Sevilla BK, Donnelly KJ, Rapaport S. The international normalized ratio (INR) for monitoring warfarin therapy: reliability and relation to other monitoring methods. Ann Intern Med. 1994 Apr 1; 120(7):552-8. PMID: 8116992.
        View in: PubMed
      19. Warn-Cramer BJ, Rapaport S. Studies of factor Xa/phospholipid-induced intravascular coagulation in rabbits. Effects of immunodepletion of tissue factor pathway inhibitor. Arterioscler Thromb. 1993 Nov; 13(11):1551-7. PMID: 8218094.
        View in: PubMed
      20. Zivelin A, Rao LV, Rapaport S. Mechanism of the anticoagulant effect of warfarin as evaluated in rabbits by selective depression of individual procoagulant vitamin K-dependent clotting factors. J Clin Invest. 1993 Nov; 92(5):2131-40. PMID: 8227329.
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      21. Rao LV, Rapaport S, Hoang AD. Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa. Blood. 1993 May 15; 81(10):2600-7. PMID: 8490170.
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      22. Callander N, Rapaport S. Trousseau's syndrome. West J Med. 1993 Apr; 158(4):364-71. PMID: 8317122.
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      23. Warn-Cramer BJ, Maki SL, Rapaport S. Heparin-releasable and platelet pools of tissue factor pathway inhibitor in rabbits. Thromb Haemost. 1993 Mar 1; 69(3):221-6. PMID: 8470044.
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      24. Rapaport S. Blood coagulation and its alterations in hemorrhagic and thrombotic disorders. West J Med. 1993 Feb; 158(2):153-61. PMID: 8434467.
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      25. Almus FE, Rao LV, Rapaport S. Regulation of factor VIIa/tissue factor functional activity in an umbilical vein model. Arterioscler Thromb. 1993 Jan; 13(1):105-11. PMID: 8422331.
        View in: PubMed
      26. Rapaport S, Rao LV. Initiation and regulation of tissue factor-dependent blood coagulation. Arterioscler Thromb. 1992 Oct; 12(10):1111-21. PMID: 1390583.
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      27. Le DT, Rapaport S, Rao LV. Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces. J Biol Chem. 1992 Aug 5; 267(22):15447-54. PMID: 1639786.
        View in: PubMed
      28. Callander NS, Rao LV, Nordfang O, Sandset PM, Warn-Cramer B, Rapaport S. Mechanisms of binding of recombinant extrinsic pathway inhibitor (rEPI) to cultured cell surfaces. Evidence that rEPI can bind to and inhibit factor VIIa-tissue factor complexes in the absence of factor Xa. J Biol Chem. 1992 Jan 15; 267(2):876-82. PMID: 1730676.
        View in: PubMed
      29. Rapaport S, Zivelin A, Minow RA, Hunter CS, Donnelly K. Clinical significance of antibodies to bovine and human thrombin and factor V after surgical use of bovine thrombin. Am J Clin Pathol. 1992 Jan; 97(1):84-91. PMID: 1728869.
        View in: PubMed
      30. Sandset PM, Warn-Cramer BJ, Maki SL, Rapaport S. Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction. Blood. 1991 Sep 15; 78(6):1496-502. PMID: 1909195.
        View in: PubMed
      31. Almus FE, Rao LV, Pendurthi UR, Quattrochi L, Rapaport S. Mechanism for diminished tissue factor expression by endothelial cells cultured with heparin binding growth factor-1 and heparin. Blood. 1991 Mar 15; 77(6):1256-62. PMID: 1705837.
        View in: PubMed
      32. Warn-Cramer BJ, Maki SL, Rapaport S. A sulfated rabbit endothelial cell glycoprotein that inhibits factor VIIa/tissue factor is functionally and immunologically identical to rabbit extrinsic pathway inhibitor (EPI). Thromb Res. 1991 Mar; 61(5-6):515-27. PMID: 2028453.
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      33. Sandset PM, Warn-Cramer BJ, Rao LV, Maki SL, Rapaport S. Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: evidence supporting a physiologic role for EPI as a natural anticoagulant. Proc Natl Acad Sci U S A. 1991 Feb 1; 88(3):708-12. PMID: 1899482.
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      34. Rapaport S. Regulation of the tissue factor pathway. Ann N Y Acad Sci. 1991; 614:51-62. PMID: 2024893.
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      35. Warr TA, Rao LV, Rapaport S. A sensitive, accurate assay for extrinsic pathway inhibitor (EPI) activity in rabbit plasma: paradoxical effect of excess exogenous factor X. Thromb Res. 1990 Aug 15; 59(4):773-82. PMID: 2080494.
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      36. Almus FE, Rao LV, Fleck RA, Rapaport S. Properties of factor VIIa/tissue factor complexes in an umbilical vein model. Blood. 1990 Jul 15; 76(2):354-60. PMID: 2114934.
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      37. Fleck RA, Rao LV, Rapaport S, Varki N. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb Res. 1990 Jul 15; 59(2):421-37. PMID: 2237820.
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      38. Warr TA, Rao LV, Rapaport S. Disseminated intravascular coagulation in rabbits induced by administration of endotoxin or tissue factor: effect of anti-tissue factor antibodies and measurement of plasma extrinsic pathway inhibitor activity. Blood. 1990 Apr 1; 75(7):1481-9. PMID: 2317559.
        View in: PubMed
      39. Rao LV, Rapaport S. Factor VIIa-catalyzed activation of factor X independent of tissue factor: its possible significance for control of hemophilic bleeding by infused factor VIIa. Blood. 1990 Mar 1; 75(5):1069-73. PMID: 2306514.
        View in: PubMed
      40. Rapaport S. Assessing hemostatic function before abdominal interventions. AJR Am J Roentgenol. 1990 Feb; 154(2):239-40. PMID: 2105006.
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      41. Rapaport S. The initiation of the tissue factor dependent pathway of blood coagulation. Adv Exp Med Biol. 1990; 281:97-103. PMID: 2102629.
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      42. Almus FE, Rao LV, Rapaport S. Functional properties of factor VIIa/tissue factor formed with purified tissue factor and with tissue factor expressed on cultured endothelial cells. Thromb Haemost. 1989 Dec 29; 62(4):1067-73. PMID: 2617454.
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      43. Warr TA, Rao LV, Rapaport S. Human plasma extrinsic pathway inhibitor activity: II. Plasma levels in disseminated intravascular coagulation and hepatocellular disease. Blood. 1989 Aug 15; 74(3):994-8. PMID: 2787683.
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      44. Warr TA, Warn-Cramer BJ, Rao LV, Rapaport S. Human plasma extrinsic pathway inhibitor activity: I. Standardization of assay and evaluation of physiologic variables. Blood. 1989 Jul; 74(1):201-6. PMID: 2473796.
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      45. Warn-Cramer BJ, Almus FE, Rapaport S. Studies of the factor Xa-dependent inhibitor of factor VIIa/tissue factor (extrinsic pathway inhibitor) from cell supernates of cultured human umbilical vein endothelial cells. Thromb Haemost. 1989 Feb 28; 61(1):101-5. PMID: 2665164.
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      46. Rapaport S. Inhibition of factor VIIa/tissue factor-induced blood coagulation: with particular emphasis upon a factor Xa-dependent inhibitory mechanism. Blood. 1989 Feb; 73(2):359-65. PMID: 2644974.
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      47. Warn-Cramer BJ, Rao LV, Maki SL, Rapaport S. Modifications of extrinsic pathway inhibitor (EPI) and factor Xa that affect their ability to interact and to inhibit factor VIIa/tissue factor: evidence for a two-step model of inhibition. Thromb Haemost. 1988 Dec 22; 60(3):453-6. PMID: 3238648.
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      48. Rao LV, Rapaport S. Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6687-91. PMID: 3261869.
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      49. Rao LV, Rapaport S. The effect of platelets upon factor Xa-catalyzed activation of factor VII in vitro. Blood. 1988 Aug; 72(2):396-401. PMID: 3135857.
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      50. Fleck RA, Rapaport S, Rao LV. Anti-prothrombin antibodies and the lupus anticoagulant. Blood. 1988 Aug; 72(2):512-9. PMID: 2456797.
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      51. Almus FE, Rao LV, Rapaport S. Decreased inducibility of tissue factor activity on human umbilical vein endothelial cells cultured with endothelial cell growth factor and heparin. Thromb Res. 1988 Apr 15; 50(2):339-44. PMID: 3394119.
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      52. Rao LV, Rapaport S, Lorenzi M. Enhancement by human umbilical vein endothelial cells of factor Xa-catalyzed activation of factor VII. Blood. 1988 Mar; 71(3):791-6. PMID: 3422831.
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      53. Warn-Cramer BJ, Maki SL, Zivelin A, Rapaport S. Partial purification and characterization of extrinsic pathway inhibitor (the factor Xa-dependent plasma inhibitor of factor VIIa/tissue factor). Thromb Res. 1987 Oct 1; 48(1):11-22. PMID: 3501173.
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      54. Rao LV, Rapaport S. Affinity purification of human brain tissue factor utilizing factor VII bound to immobilized anti-factor VII. Anal Biochem. 1987 Sep; 165(2):365-70. PMID: 3425896.
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