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Pascal Gagneux

Title(s)Professor In Residence, Pathology
SchoolHealth Sciences
Phone858-822-4030
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    Collapse Research 
    Collapse Research Activities and Funding
    Glycan array for phenotype-driven capture and genotyping of viruses in primary isolates
    NIH/NIAID R21AI129894Sep 1, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Glycan Diversity and Anti-Glycan Antibodies as Barriers to Gene Flow
    NIH/NIGMS R01GM095882Jul 15, 2011 - Apr 30, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vangenot C, Gagneux P, de Groot NG, Baumeyer A, Mouterde M, Crouau-Roy B, Darlu P, Sanchez-Mazas A, Sabbagh A, Poloni ES. Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes. G3 (Bethesda). 2019 07 09; 9(7):2199-2224. PMID: 31068377.
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    2. Tecle E, Reynoso HS, Wang R, Gagneux P. The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival. J Biol Chem. 2019 Aug 02; 294(31):11910-11919. PMID: 31201275.
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    3. Altman MO, Gagneux P. Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans-An Evolutionary Perspective. Front Immunol. 2019; 10:789. PMID: 31134048.
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    4. Jeste DV, Lee EE, Cassidy C, Caspari R, Gagneux P, Glorioso D, Miller BL, Semendeferi K, Vogler C, Nusbaum H, Blazer D. The New Science of Practical Wisdom. Perspect Biol Med. 2019; 62(2):216-236. PMID: 31281119.
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    5. Lindheim SR, Glenn TL, Smith MC, Gagneux P. Ovulation Induction for the General Gynecologist. J Obstet Gynaecol India. 2018 Aug; 68(4):242-252. PMID: 30065537.
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    6. Qu J, Hodges E, Molaro A, Gagneux P, Dean MD, Hannon GJ, Smith AD. Corrigendum: Evolutionary expansion of DNA hypomethylation in the mammalian germline genome. Genome Res. 2018 05; 28(5):766.2. PMID: 29717002.
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    7. Glenn TL, Bembry J, Findley AD, Yaklic JL, Bhagavath B, Gagneux P, Lindheim SR. Cesarean Scar Ectopic Pregnancy: Current Management Strategies. Obstet Gynecol Surv. 2018 May; 73(5):293-302. PMID: 29850919.
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    8. Qu J, Hodges E, Molaro A, Gagneux P, Dean MD, Hannon GJ, Smith AD. Evolutionary expansion of DNA hypomethylation in the mammalian germline genome. Genome Res. 2018 02; 28(2):145-158. PMID: 29259021.
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    9. Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A. N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8155-E8164. PMID: 28893995.
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    10. Havemann LM, Cool DR, Gagneux P, Markey MP, Yaklic JL, Maxwell RA, Iyer A, Lindheim SR. Vulvodynia: What We Know and Where We Should Be Going. J Low Genit Tract Dis. 2017 Apr; 21(2):150-156. PMID: 27984345.
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    11. Springer S, Gagneux P. [New genes protect old minds]. Med Sci (Paris). 2016 Oct; 32(10):806-808. PMID: 27758736.
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    12. Cohen M, Senaati HP, Fisher CJ, Huang ML, Gagneux P, Godula K. Synthetic Mucus Nanobarriers for Identification of Glycan-Dependent Primary Influenza A Infection Inhibitors. ACS Cent Sci. 2016 Oct 26; 2(10):710-714. PMID: 27800553.
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    13. Ma F, Deng L, Secrest P, Shi L, Zhao J, Gagneux P. A Mouse Model for Dietary Xenosialitis: ANTIBODIES TO XENOGLYCAN CAN REDUCE FERTILITY. J Biol Chem. 2016 08 26; 291(35):18222-31. PMID: 27382056.
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    14. Ma X, Pan Q, Feng Y, Choudhury BP, Ma Q, Gagneux P, Ma F. Sialylation Facilitates the Maturation of Mammalian Sperm and Affects Its Survival in Female Uterus. Biol Reprod. 2016 06; 94(6):123. PMID: 27075617.
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    15. Cohen M, Fisher CJ, Huang ML, Lindsay LL, Plancarte M, Boyce WM, Godula K, Gagneux P. Capture and characterization of influenza A virus from primary samples using glycan bead arrays. Virology. 2016 06; 493:128-35. PMID: 27031581.
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    16. Springer SA, Schwarz F, Altheide TK, Varki NM, Varki A, Gagneux P. Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):E1591-2. PMID: 26933219.
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    17. Schwarz F, Springer SA, Altheide TK, Varki NM, Gagneux P, Varki A. Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):74-9. PMID: 26621708.
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    18. Springer SA, Gagneux P. Glycomics: revealing the dynamic ecology and evolution of sugar molecules. J Proteomics. 2016 Mar 01; 135:90-100. PMID: 26626628.
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    19. Lindheim SR, Gagneux P. A sweet view of reproduction. Fertil Steril. 2015 Sep; 104(3):533. PMID: 26149356.
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    20. Tecle E, Gagneux P. Sugar-coated sperm: Unraveling the functions of the mammalian sperm glycocalyx. Mol Reprod Dev. 2015 Sep; 82(9):635-50. PMID: 26061344.
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    21. Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, Varki A, Gagneux P. Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife. 2015 Apr 07; 4. PMID: 25846707.
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    22. Huang ML, Cohen M, Fisher CJ, Schooley RT, Gagneux P, Godula K. Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays. Chem Commun (Camb). 2015 Mar 28; 51(25):5326-9. PMID: 25574528.
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    23. Niv Y, Boltin D, Halpern M, Cohen M, Levi Z, Vilkin A, Morgenstern S, Manugian V, St Lawrence E, Gagneux P, Kaur S, Sharma P, Batra SK, Ho SB. Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers. World J Gastroenterol. 2014 Oct 28; 20(40):14913-20. PMID: 25356051.
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    24. Springer SA, Diaz SL, Gagneux P. Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc. Immunogenetics. 2014 Nov; 66(11):671-4. PMID: 25124893.
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    25. Cohen M, Zhang XQ, Senaati HP, Chen HW, Varki NM, Schooley RT, Gagneux P. Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virol J. 2013 Nov 22; 10:321. PMID: 24261589.
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    26. Prado-Martinez J, Sudmant PH, Kidd JM, Li H, Kelley JL, Lorente-Galdos B, Veeramah KR, Woerner AE, O'Connor TD, Santpere G, Cagan A, Theunert C, Casals F, Laayouni H, Munch K, Hobolth A, Halager AE, Malig M, Hernandez-Rodriguez J, Hernando-Herraez I, Prüfer K, Pybus M, Johnstone L, Lachmann M, Alkan C, Twigg D, Petit N, Baker C, Hormozdiari F, Fernandez-Callejo M, Dabad M, Wilson ML, Stevison L, Camprubí C, Carvalho T, Ruiz-Herrera A, Vives L, Mele M, Abello T, Kondova I, Bontrop RE, Pusey A, Lankester F, Kiyang JA, Bergl RA, Lonsdorf E, Myers S, Ventura M, Gagneux P, Comas D, Siegismund H, Blanc J, Agueda-Calpena L, Gut M, Fulton L, Tishkoff SA, Mullikin JC, Wilson RK, Gut IG, Gonder MK, Ryder OA, Hahn BH, Navarro A, Akey JM, Bertranpetit J, Reich D, Mailund T, Schierup MH, Hvilsom C, Andrés AM, Wall JD, Bustamante CD, Hammer MF, Eichler EE, Marques-Bonet T. Great ape genetic diversity and population history. Nature. 2013 Jul 25; 499(7459):471-5. PMID: 23823723.
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    27. Springer SA, Gagneux P. Glycan evolution in response to collaboration, conflict, and constraint. J Biol Chem. 2013 Mar 08; 288(10):6904-11. PMID: 23329843.
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    28. O'Bleness M, Searles VB, Varki A, Gagneux P, Sikela JM. Evolution of genetic and genomic features unique to the human lineage. Nat Rev Genet. 2012 Dec; 13(12):853-66. PMID: 23154808.
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    29. Cohen M, Varki NM, Jankowski MD, Gagneux P. Using unfixed, frozen tissues to study natural mucin distribution. J Vis Exp. 2012 Sep 21; (67):e3928. PMID: 23023050.
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    30. Ma F, Wu D, Deng L, Secrest P, Zhao J, Varki N, Lindheim S, Gagneux P. Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. J Biol Chem. 2012 Nov 02; 287(45):38073-9. PMID: 22989879.
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    31. Davies LR, Pearce OM, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: resistance of a2-8-linked N-glycolylneuraminic acid to enzymatic cleavage. J Biol Chem. 2012 Aug 17; 287(34):28917-31. PMID: 22692207.
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    32. Niv Y, Boltin D, Halpern M, Cohen M, Levi Z, Vilkin A, Morgenstern S, Manugian V, St Lawrence E, Gagneux P, Batra SK, Ho SB. Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers. Dig Dis Sci. 2012 Oct; 57(10):2535-44. PMID: 22576713.
      View in: PubMed
    33. Varki A, Gagneux P. Multifarious roles of sialic acids in immunity. Ann N Y Acad Sci. 2012 Apr; 1253:16-36. PMID: 22524423.
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    34. Ghaderi D, Springer SA, Ma F, Cohen M, Secrest P, Taylor RE, Varki A, Gagneux P. Sexual selection by female immunity against paternal antigens can fix loss of function alleles. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17743-8. PMID: 21987817.
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    35. Babb PL, Fernandez-Duque E, Baiduc CA, Gagneux P, Evans S, Schurr TG. mtDNA diversity in Azara's owl monkeys (Aotus azarai azarai) of the Argentinean Chaco. Am J Phys Anthropol. 2011 Oct; 146(2):209-24. PMID: 21826638.
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    36. Tao N, Wu S, Kim J, An HJ, Hinde K, Power ML, Gagneux P, German JB, Lebrilla CB. Evolutionary glycomics: characterization of milk oligosaccharides in primates. J Proteome Res. 2011 Apr 01; 10(4):1548-57. PMID: 21214271.
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    37. Dall'Olio GM, Jassal B, Montanucci L, Gagneux P, Bertranpetit J, Laayouni H. The annotation of the asparagine N-linked glycosylation pathway in the Reactome database. Glycobiology. 2011 Nov; 21(11):1395-400. PMID: 21199820.
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    38. Varki A, Gagneux P. Human-specific evolution of sialic acid targets: explaining the malignant malaria mystery? Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14739-40. PMID: 19717444.
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    39. Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13552-7. PMID: 19666579.
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    40. Nascimento JM, Shi LZ, Meyers S, Gagneux P, Loskutoff NM, Botvinick EL, Berns MW. The use of optical tweezers to study sperm competition and motility in primates. J R Soc Interface. 2008 Mar 06; 5(20):297-302. PMID: 17650470.
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    41. Anderson MJ, Chapman SJ, Videan EN, Evans E, Fritz J, Stoinski TS, Dixson AF, Gagneux P. Functional evidence for differences in sperm competition in humans and chimpanzees. Am J Phys Anthropol. 2007 Oct; 134(2):274-80. PMID: 17632799.
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    42. Schrenzel M, Snook E, Gagneux P. Molecular assays for detection of falcon adenovirus. J Vet Diagn Invest. 2007 Sep; 19(5):479-85. PMID: 17823390.
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    43. Baena A, Mootnick AR, Falvo JV, Tsytskova AV, Ligeiro F, Diop OM, Brieva C, Gagneux P, O'Brien SJ, Ryder OA, Goldfeld AE. Primate TNF promoters reveal markers of phylogeny and evolution of innate immunity. PLoS One. 2007 Jul 18; 2(7):e621. PMID: 17637837.
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    44. Bishop JR, Gagneux P. Evolution of carbohydrate antigens--microbial forces shaping host glycomes? Glycobiology. 2007 May; 17(5):23R-34R. PMID: 17237137.
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    45. Nguyen DH, Hurtado-Ziola N, Gagneux P, Varki A. Loss of Siglec expression on T lymphocytes during human evolution. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7765-70. PMID: 16682635.
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    46. Ely JJ, Dye B, Frels WI, Fritz J, Gagneux P, Khun HH, Switzer WM, Lee DR. Subspecies composition and founder contribution of the captive U.S. chimpanzee (Pan troglodytes) population. Am J Primatol. 2005 Oct; 67(2):223-41. PMID: 16229023.
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    47. Gagneux P, Moore JJ, Varki A. The ethics of research on great apes. Nature. 2005 Sep 01; 437(7055):27-9. PMID: 16136111.
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    48. Martin MJ, Rayner JC, Gagneux P, Barnwell JW, Varki A. Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12819-24. PMID: 16126901.
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    49. Gagneux P, Muchmore EA. The chimpanzee model: contributions and considerations for studies of hepatitis B virus. Methods Mol Med. 2004; 96:289-318. PMID: 14762278.
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    50. Tangvoranuntakul P, Gagneux P, Diaz S, Bardor M, Varki N, Varki A, Muchmore E. Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12045-50. PMID: 14523234.
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    51. Gagneux P, Cheriyan M, Hurtado-Ziola N, van der Linden EC, Anderson D, McClure H, Varki A, Varki NM. Human-specific regulation of alpha 2-6-linked sialic acids. J Biol Chem. 2003 Nov 28; 278(48):48245-50. PMID: 14500706.
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    52. de Groot NG, Otting N, Doxiadis GG, Balla-Jhagjhoorsingh SS, Heeney JL, van Rood JJ, Gagneux P, Bontrop RE. Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11748-53. PMID: 12186979.
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    53. Gagneux P. The genus Pan: population genetics of an endangered outgroup. Trends Genet. 2002 Jul; 18(7):327-30. PMID: 12127763.
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    54. Hu X, Javadian A, Gagneux P, Robertson BH. Paired chimpanzee hepatitis B virus (ChHBV) and mtDNA sequences suggest different ChHBV genetic variants are found in geographically distinct chimpanzee subspecies. Virus Res. 2001 Nov 05; 79(1-2):103-8. PMID: 11551650.
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    55. Hayakawa T, Satta Y, Gagneux P, Varki A, Takahata N. Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11399-404. PMID: 11562455.
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    56. Gagneux P, Gonder MK, Goldberg TL, Morin PA. Gene flow in wild chimpanzee populations: what genetic data tell us about chimpanzee movement over space and time. Philos Trans R Soc Lond B Biol Sci. 2001 Jun 29; 356(1410):889-97. PMID: 11405936.
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    57. Gagneux P, Amess B, Diaz S, Moore S, Patel T, Dillmann W, Parekh R, Varki A. Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism. Am J Phys Anthropol. 2001 Jun; 115(2):99-109. PMID: 11385598.
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    58. Gagneux P, Varki A. Genetic differences between humans and great apes. Mol Phylogenet Evol. 2001 Jan; 18(1):2-13. PMID: 11161737.
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    59. Gagneux P, Varki A. Evolutionary considerations in relating oligosaccharide diversity to biological function. Glycobiology. 1999 Aug; 9(8):747-55. PMID: 10406840.
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    60. Gagneux P, Wills C, Gerloff U, Tautz D, Morin PA, Boesch C, Fruth B, Hohmann G, Ryder OA, Woodruff DS. Mitochondrial sequences show diverse evolutionary histories of African hominoids. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5077-82. PMID: 10220421.
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    61. Gagneux P, Boesch C, Woodruff DS. Microsatellite scoring errors associated with noninvasive genotyping based on nuclear DNA amplified from shed hair. Mol Ecol. 1997 Sep; 6(9):861-8. PMID: 9301074.
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    62. Gagneux P, Woodruff DS, Boesch C. Furtive mating in female chimpanzees. Nature. 1997 May 22; 387(6631):358-9. PMID: 9163418.
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