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Pascal Gagneux

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Glycan array for phenotype-driven capture and genotyping of viruses in primary isolates
    NIH R21AI129894Sep 1, 2016 - Aug 31, 2019
    Role: Principal Investigator
    Glycan Diversity and Anti-Glycan Antibodies as Barriers to Gene Flow
    NIH R01GM095882Jul 15, 2011 - Apr 30, 2017
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins. Genome Biol Evol. 2020 Jul 01; 12(7):1040-1050. Khan N, de Manuel M, Peyregne S, Do R, Prufer K, Marques-Bonet T, Varki N, Gagneux P, Varki A. PMID: 32556248.
      View in: PubMed   Mentions:    Fields:    
    2. Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging. FASEB J. 2020 02; 34(2):1928-1938. Khan N, Kim SK, Gagneux P, Dugan LL, Varki A. PMID: 31907986.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes. G3 (Bethesda). 2019 07 09; 9(7):2199-2224. Vangenot C, Gagneux P, de Groot NG, Baumeyer A, Mouterde M, Crouau-Roy B, Darlu P, Sanchez-Mazas A, Sabbagh A, Poloni ES. PMID: 31068377.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    4. The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival. J Biol Chem. 2019 08 02; 294(31):11910-11919. Tecle E, Reynoso HS, Wang R, Gagneux P. PMID: 31201275.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans-An Evolutionary Perspective. Front Immunol. 2019; 10:789. Altman MO, Gagneux P. PMID: 31134048.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. The New Science of Practical Wisdom. Perspect Biol Med. 2019; 62(2):216-236. Jeste DV, Lee EE, Cassidy C, Caspari R, Gagneux P, Glorioso D, Miller BL, Semendeferi K, Vogler C, Nusbaum H, Blazer D. PMID: 31281119.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Ovulation Induction for the General Gynecologist. J Obstet Gynaecol India. 2018 Aug; 68(4):242-252. Lindheim SR, Glenn TL, Smith MC, Gagneux P. PMID: 30065537.
      View in: PubMed   Mentions:    Fields:    
    8. Corrigendum: Evolutionary expansion of DNA hypomethylation in the mammalian germline genome. Genome Res. 2018 05; 28(5):766.2. Qu J, Hodges E, Molaro A, Gagneux P, Dean MD, Hannon GJ, Smith AD. PMID: 29717002.
      View in: PubMed   Mentions:    Fields:    
    9. Cesarean Scar Ectopic Pregnancy: Current Management Strategies. Obstet Gynecol Surv. 2018 May; 73(5):293-302. Glenn TL, Bembry J, Findley AD, Yaklic JL, Bhagavath B, Gagneux P, Lindheim SR. PMID: 29850919.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Evolutionary expansion of DNA hypomethylation in the mammalian germline genome. Genome Res. 2018 02; 28(2):145-158. Qu J, Hodges E, Molaro A, Gagneux P, Dean MD, Hannon GJ, Smith AD. PMID: 29259021.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8155-E8164. Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A. PMID: 28893995.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Vulvodynia: What We Know and Where We Should Be Going. J Low Genit Tract Dis. 2017 Apr; 21(2):150-156. PMID: 27984345.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. [New genes protect old minds]. Med Sci (Paris). 2016 Oct; 32(10):806-808. PMID: 27758736.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. Synthetic Mucus Nanobarriers for Identification of Glycan-Dependent Primary Influenza A Infection Inhibitors. ACS Cent Sci. 2016 Oct 26; 2(10):710-714. PMID: 27800553.
      View in: PubMed   Mentions:
    15. A Mouse Model for Dietary Xenosialitis: ANTIBODIES TO XENOGLYCAN CAN REDUCE FERTILITY. J Biol Chem. 2016 08 26; 291(35):18222-31. PMID: 27382056.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Sialylation Facilitates the Maturation of Mammalian Sperm and Affects Its Survival in Female Uterus. Biol Reprod. 2016 06; 94(6):123. PMID: 27075617.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. Capture and characterization of influenza A virus from primary samples using glycan bead arrays. Virology. 2016 06; 493:128-35. PMID: 27031581.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):E1591-2. PMID: 26933219.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    19. Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):74-9. PMID: 26621708.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. Glycomics: revealing the dynamic ecology and evolution of sugar molecules. J Proteomics. 2016 Mar 01; 135:90-100. PMID: 26626628.
      View in: PubMed   Mentions: 5     Fields:    
    21. A sweet view of reproduction. Fertil Steril. 2015 Sep; 104(3):533. PMID: 26149356.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    22. Sugar-coated sperm: Unraveling the functions of the mammalian sperm glycocalyx. Mol Reprod Dev. 2015 Sep; 82(9):635-50. PMID: 26061344.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    23. Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife. 2015 Apr 07; 4. PMID: 25846707.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    24. Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays. Chem Commun (Camb). 2015 Mar 28; 51(25):5326-9. PMID: 25574528.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    25. Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers. World J Gastroenterol. 2014 Oct 28; 20(40):14913-20. PMID: 25356051.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc. Immunogenetics. 2014 Nov; 66(11):671-4. PMID: 25124893.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    27. Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virol J. 2013 Nov 22; 10:321. PMID: 24261589.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    28. Great ape genetic diversity and population history. Nature. 2013 Jul 25; 499(7459):471-5. PMID: 23823723.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimals
    29. Glycan evolution in response to collaboration, conflict, and constraint. J Biol Chem. 2013 Mar 08; 288(10):6904-11. PMID: 23329843.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    30. Evolution of genetic and genomic features unique to the human lineage. Nat Rev Genet. 2012 Dec; 13(12):853-66. PMID: 23154808.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    31. Using unfixed, frozen tissues to study natural mucin distribution. J Vis Exp. 2012 Sep 21; (67):e3928. PMID: 23023050.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    32. Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. J Biol Chem. 2012 Nov 02; 287(45):38073-9. PMID: 22989879.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    33. Metabolism of vertebrate amino sugars with N-glycolyl groups: resistance of a2-8-linked N-glycolylneuraminic acid to enzymatic cleavage. J Biol Chem. 2012 Aug 17; 287(34):28917-31. PMID: 22692207.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    34. Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers. Dig Dis Sci. 2012 Oct; 57(10):2535-44. PMID: 22576713.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Multifarious roles of sialic acids in immunity. Ann N Y Acad Sci. 2012 Apr; 1253:16-36. PMID: 22524423.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    36. Sexual selection by female immunity against paternal antigens can fix loss of function alleles. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17743-8. Ghaderi D, Springer SA, Ma F, Cohen M, Secrest P, Taylor RE, Varki A, Gagneux P. PMID: 21987817.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    37. mtDNA diversity in Azara's owl monkeys (Aotus azarai azarai) of the Argentinean Chaco. Am J Phys Anthropol. 2011 Oct; 146(2):209-24. Babb PL, Fernandez-Duque E, Baiduc CA, Gagneux P, Evans S, Schurr TG. PMID: 21826638.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    38. Evolutionary glycomics: characterization of milk oligosaccharides in primates. J Proteome Res. 2011 Apr 01; 10(4):1548-57. Tao N, Wu S, Kim J, An HJ, Hinde K, Power ML, Gagneux P, German JB, Lebrilla CB. PMID: 21214271.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    39. The annotation of the asparagine N-linked glycosylation pathway in the Reactome database. Glycobiology. 2011 Nov; 21(11):1395-400. PMID: 21199820.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    40. Human-specific evolution of sialic acid targets: explaining the malignant malaria mystery? Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14739-40. Varki A, Gagneux P. PMID: 19717444.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    41. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13552-7. Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A. PMID: 19666579.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    42. The use of optical tweezers to study sperm competition and motility in primates. J R Soc Interface. 2008 Mar 06; 5(20):297-302. Nascimento JM, Shi LZ, Meyers S, Gagneux P, Loskutoff NM, Botvinick EL, Berns MW. PMID: 17650470.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    43. Functional evidence for differences in sperm competition in humans and chimpanzees. Am J Phys Anthropol. 2007 Oct; 134(2):274-80. Anderson MJ, Chapman SJ, Videan EN, Evans E, Fritz J, Stoinski TS, Dixson AF, Gagneux P. PMID: 17632799.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    44. Molecular assays for detection of falcon adenovirus. J Vet Diagn Invest. 2007 Sep; 19(5):479-85. Schrenzel M, Snook E, Gagneux P. PMID: 17823390.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    45. Primate TNF promoters reveal markers of phylogeny and evolution of innate immunity. PLoS One. 2007 Jul 18; 2(7):e621. Baena A, Mootnick AR, Falvo JV, Tsytskova AV, Ligeiro F, Diop OM, Brieva C, Gagneux P, O'Brien SJ, Ryder OA, Goldfeld AE. PMID: 17637837.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    46. Evolution of carbohydrate antigens--microbial forces shaping host glycomes? Glycobiology. 2007 May; 17(5):23R-34R. Bishop JR, Gagneux P. PMID: 17237137.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    47. Loss of Siglec expression on T lymphocytes during human evolution. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7765-70. Nguyen DH, Hurtado-Ziola N, Gagneux P, Varki A. PMID: 16682635.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    48. Subspecies composition and founder contribution of the captive U.S. chimpanzee (Pan troglodytes) population. Am J Primatol. 2005 Oct; 67(2):223-41. Ely JJ, Dye B, Frels WI, Fritz J, Gagneux P, Khun HH, Switzer WM, Lee DR. PMID: 16229023.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    49. The ethics of research on great apes. Nature. 2005 Sep 01; 437(7055):27-9. Gagneux P, Moore JJ, Varki A. PMID: 16136111.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    50. Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12819-24. Martin MJ, Rayner JC, Gagneux P, Barnwell JW, Varki A. PMID: 16126901.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    51. The chimpanzee model: contributions and considerations for studies of hepatitis B virus. Methods Mol Med. 2004; 96:289-318. Gagneux P, Muchmore EA. PMID: 14762278.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    52. Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12045-50. Tangvoranuntakul P, Gagneux P, Diaz S, Bardor M, Varki N, Varki A, Muchmore E. PMID: 14523234.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    53. Human-specific regulation of alpha 2-6-linked sialic acids. J Biol Chem. 2003 Nov 28; 278(48):48245-50. Gagneux P, Cheriyan M, Hurtado-Ziola N, van der Linden EC, Anderson D, McClure H, Varki A, Varki NM. PMID: 14500706.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    54. Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11748-53. de Groot NG, Otting N, Doxiadis GG, Balla-Jhagjhoorsingh SS, Heeney JL, van Rood JJ, Gagneux P, Bontrop RE. PMID: 12186979.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    55. The genus Pan: population genetics of an endangered outgroup. Trends Genet. 2002 Jul; 18(7):327-30. Gagneux P. PMID: 12127763.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    56. Paired chimpanzee hepatitis B virus (ChHBV) and mtDNA sequences suggest different ChHBV genetic variants are found in geographically distinct chimpanzee subspecies. Virus Res. 2001 Nov 05; 79(1-2):103-8. Hu X, Javadian A, Gagneux P, Robertson BH. PMID: 11551650.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    57. Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11399-404. Hayakawa T, Satta Y, Gagneux P, Varki A, Takahata N. PMID: 11562455.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    58. Gene flow in wild chimpanzee populations: what genetic data tell us about chimpanzee movement over space and time. Philos Trans R Soc Lond B Biol Sci. 2001 Jun 29; 356(1410):889-97. Gagneux P, Gonder MK, Goldberg TL, Morin PA. PMID: 11405936.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    59. Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism. Am J Phys Anthropol. 2001 Jun; 115(2):99-109. Gagneux P, Amess B, Diaz S, Moore S, Patel T, Dillmann W, Parekh R, Varki A. PMID: 11385598.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    60. Genetic differences between humans and great apes. Mol Phylogenet Evol. 2001 Jan; 18(1):2-13. Gagneux P, Varki A. PMID: 11161737.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    61. Evolutionary considerations in relating oligosaccharide diversity to biological function. Glycobiology. 1999 Aug; 9(8):747-55. Gagneux P, Varki A. PMID: 10406840.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    62. Mitochondrial sequences show diverse evolutionary histories of African hominoids. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5077-82. Gagneux P, Wills C, Gerloff U, Tautz D, Morin PA, Boesch C, Fruth B, Hohmann G, Ryder OA, Woodruff DS. PMID: 10220421.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    63. Microsatellite scoring errors associated with noninvasive genotyping based on nuclear DNA amplified from shed hair. Mol Ecol. 1997 Sep; 6(9):861-8. Gagneux P, Boesch C, Woodruff DS. PMID: 9301074.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    64. Furtive mating in female chimpanzees. Nature. 1997 May 22; 387(6631):358-9. Gagneux P, Woodruff DS, Boesch C. PMID: 9163418.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
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