Li-fan Lu

Title(s)Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Functional dissection of the Klrg1+ regulatory T cell subset in health and diseases
    NIH R21AI163813Jul 1, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Function of tissue-specific regulatory T cells in health and disease
    NIH R21AI140095May 3, 2018 - Apr 30, 2020
    Role: Principal Investigator
    Specialization of regulatory T cell-mediated immune regulation during Toxoplasma infection
    NIH R56AI127751Aug 3, 2017 - Jul 31, 2018
    Role: Principal Investigator
    Role of miR-146a at the interface between T and B cell immunity
    NIH R21AI123782Feb 12, 2016 - Jul 31, 2018
    Role: Principal Investigator
    MicroRNA-mediated control of immune responses and tolerance
    NIH R01AI108651Apr 1, 2014 - Jan 31, 2025
    Role: Principal Investigator
    The role of SOCS1 repression by miR-155 in regulating immune responsiveness
    NIH R21AI103646Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Function of microRNAs in controlling regulatory T cell biology
    NIH R00AI089935Mar 9, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Function of microRNAs in controlling regulatory T cell biology
    NIH K99AI089935Mar 1, 2011 - Mar 8, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18423-18428. Xu H, Tong Z, Ye Q, Sun T, Hong Z, Zhang L, Bortnick A, Cho S, Beuzer P, Axelrod J, Hu Q, Wang M, Evans SM, Murre C, Lu LF, Sun S, Corbett KD, Cang H. PMID: 31444302; PMCID: PMC6744910.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    2. Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival. J Immunother Cancer. 2019 07 31; 7(1):201. Sorrentino C, Yin Z, Ciummo S, Lanuti P, Lu LF, Marchisio M, Bellone M, Di Carlo E. PMID: 31366386; PMCID: PMC6670138.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    3. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 2019 06 18; 27(12):3629-3645.e6. Yang BH, Wang K, Wan S, Liang Y, Yuan X, Dong Y, Cho S, Xu W, Jepsen K, Feng GS, Lu LF, Xue HH, Fu W. PMID: 31216480; PMCID: PMC6701704.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    4. TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion. Proc Natl Acad Sci U S A. 2019 06 18; 116(25):12410-12415. Seo H, Chen J, González-Avalos E, Samaniego-Castruita D, Das A, Wang YH, López-Moyado IF, Georges RO, Zhang W, Onodera A, Wu CJ, Lu LF, Hogan PG, Bhandoola A, Rao A. PMID: 31152140; PMCID: PMC6589758.
      View in: PubMed   Mentions: 308     Fields:    Translation:AnimalsCells
    5. An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice. Hepatology. 2019 06; 69(6):2518-2532. Wen L, Xin B, Wu P, Lin CH, Peng C, Wang G, Lee J, Lu LF, Feng GS. PMID: 30693544; PMCID: PMC6541536.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    6. Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nat Commun. 2018 08 16; 9(1):3338. Mann M, Mehta A, Zhao JL, Lee K, Marinov GK, Garcia-Flores Y, Lu LF, Rudensky AY, Baltimore D. PMID: 30115909; PMCID: PMC6095848.
      View in: PubMed   Mentions: 7     Fields:    
    7. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 2018 07 16; 9(1):2757. Cho S, Lee HM, Yu IS, Choi YS, Huang HY, Hashemifar SS, Lin LL, Chen MC, Afanasiev ND, Khan AA, Lin SW, Rudensky AY, Crotty S, Lu LF. PMID: 30013024; PMCID: PMC6048122.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    8. Conditional Gene-Targeting in Mice: Problems and Solutions. Immunity. 2018 05 15; 48(5):835-836. Becher B, Waisman A, Lu LF. PMID: 29768166; PMCID: PMC7771386.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    9. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. J Immunol. 2018 06 15; 200(12):4012-4023. Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg MH, Petrich BG, Chang JT. PMID: 29703862; PMCID: PMC5988969.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    10. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Cell. 2017 Dec 14; 171(7):1495-1507.e15. Liao HK, Hatanaka F, Araoka T, Reddy P, Wu MZ, Sui Y, Yamauchi T, Sakurai M, O'Keefe DD, Núñez-Delicado E, Guillen P, Campistol JM, Wu CJ, Lu LF, Esteban CR, Izpisua Belmonte JC. PMID: 29224783; PMCID: PMC5732045.
      View in: PubMed   Mentions: 189     Fields:    Translation:AnimalsCells
    11. An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nat Commun. 2017 10 11; 8(1):851. Mann M, Mehta A, Zhao JL, Lee K, Marinov GK, Garcia-Flores Y, Lu LF, Rudensky AY, Baltimore D. PMID: 29021573; PMCID: PMC5636846.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    12. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. Nat Cell Biol. 2017 Oct; 19(10):1286-1296. Wu MZ, Cheng WC, Chen SF, Nieh S, O'Connor C, Liu CL, Tsai WW, Wu CJ, Martin L, Lin YS, Wu KJ, Lu LF, Izpisua Belmonte JC. PMID: 28920955; PMCID: PMC5658024.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    13. A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses. J Immunol. 2017 05 15; 198(10):3919-3926. Cho S, Wu CJ, Nguyen DT, Lin LL, Chen MC, Khan AA, Yang BH, Fu W, Lu LF. PMID: 28404635; PMCID: PMC5437976.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow. Cell Rep. 2017 02 21; 18(8):1906-1916. Glatman Zaretsky A, Konradt C, Dépis F, Wing JB, Goenka R, Atria DG, Silver JS, Cho S, Wolf AI, Quinn WJ, Engiles JB, Brown DC, Beiting D, Erikson J, Allman D, Cancro MP, Sakaguchi S, Lu LF, Benoist CO, Hunter CA. PMID: 28228257; PMCID: PMC5361408.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    15. Excessive expression of miR-27 impairs Treg-mediated immunological tolerance. J Clin Invest. 2017 Feb 01; 127(2):530-542. Cruz LO, Hashemifar SS, Wu CJ, Cho S, Nguyen DT, Lin LL, Khan AA, Lu LF. PMID: 28067667; PMCID: PMC5272185.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    16. MicroRNA in Immune Regulation. Curr Top Microbiol Immunol. 2017; 410:249-267. Wu CJ, Lu LF. PMID: 28900683; PMCID: PMC8476048.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    17. A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. J Exp Med. 2016 08 22; 213(9):1901-19. Liu WH, Kang SG, Huang Z, Wu CJ, Jin HY, Maine CJ, Liu Y, Shepherd J, Sabouri-Ghomi M, Gonzalez-Martin A, Xu S, Hoffmann A, Zheng Y, Lu LF, Xiao N, Fu G, Xiao C. PMID: 27481129; PMCID: PMC4995083.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    18. Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation. Nat Immunol. 2016 07; 17(7):834-43. Shaw LA, Bélanger S, Omilusik KD, Cho S, Scott-Browne JP, Nance JP, Goulding J, Lasorella A, Lu LF, Crotty S, Goldrath AW. PMID: 27213691; PMCID: PMC4915968.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    19. miR-23∼27∼24 clusters control effector T cell differentiation and function. J Exp Med. 2016 Feb 08; 213(2):235-49. Cho S, Wu CJ, Yasuda T, Cruz LO, Khan AA, Lin LL, Nguyen DT, Miller M, Lee HM, Kuo ML, Broide DH, Rajewsky K, Rudensky AY, Lu LF. PMID: 26834155; PMCID: PMC4749926.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    20. A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner. Immunity. 2015 Jul 21; 43(1):52-64. Lu LF, Gasteiger G, Yu IS, Chaudhry A, Hsin JP, Lu Y, Bos PD, Lin LL, Zawislak CL, Cho S, Sun JC, Leslie CS, Lin SW, Rudensky AY. PMID: 26163372; PMCID: PMC4529747.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    21. IFNγ signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet+ regulatory T cells. PLoS Pathog. 2015 Feb; 11(2):e1004635. Lee HM, Fleige A, Forman R, Cho S, Khan AA, Lin LL, Nguyen DT, O'Hara-Hall A, Yin Z, Hunter CA, Muller W, Lu LF. PMID: 25658840; PMCID: PMC4450074.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    22. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Nat Immunol. 2014 Aug; 15(8):767-76. Miyazaki M, Miyazaki K, Chen S, Itoi M, Miller M, Lu LF, Varki N, Chang AN, Broide DH, Murre C. PMID: 24973820; PMCID: PMC4365819.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    23. Progress and challenge of microRNA research in immunity. Front Genet. 2014; 5:178. Lee HM, Nguyen DT, Lu LF. PMID: 24971086; PMCID: PMC4053854.
      View in: PubMed   Mentions: 42  
    24. Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Nat Commun. 2014; 5:3344. Ho BC, Yu IS, Lu LF, Rudensky A, Chen HY, Tsai CW, Chang YL, Wu CT, Chang LY, Shih SR, Lin SW, Lee CN, Yang PC, Yu SL. PMID: 24561744.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    25. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol. 2013 Sep; 14(9):959-65. Pierson W, Cauwe B, Policheni A, Schlenner SM, Franckaert D, Berges J, Humblet-Baron S, Schönefeldt S, Herold MJ, Hildeman D, Strasser A, Bouillet P, Lu LF, Matthys P, Freitas AA, Luther RJ, Weaver CT, Dooley J, Gray DH, Liston A. PMID: 23852275; PMCID: PMC4128388.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    26. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012; 30:531-64. Josefowicz SZ, Lu LF, Rudensky AY. PMID: 22224781; PMCID: PMC6066374.
      View in: PubMed   Mentions: 1386     Fields:    Translation:HumansAnimalsCells
    27. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J Exp Med. 2011 Mar 14; 208(3):577-92. Wang L, Rubinstein R, Lines JL, Wasiuk A, Ahonen C, Guo Y, Lu LF, Gondek D, Wang Y, Fava RA, Fiser A, Almo S, Noelle RJ. PMID: 21383057; PMCID: PMC3058578.
      View in: PubMed   Mentions: 342     Fields:    Translation:AnimalsCells
    28. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010 Sep 17; 142(6):914-29. Lu LF, Boldin MP, Chaudhry A, Lin LL, Taganov KD, Hanada T, Yoshimura A, Baltimore D, Rudensky AY. PMID: 20850013; PMCID: PMC3049116.
      View in: PubMed   Mentions: 473     Fields:    Translation:AnimalsCells
    29. MicroRNA in the adaptive immune system, in sickness and in health. J Clin Immunol. 2010 May; 30(3):339-46. Liston A, Linterman M, Lu LF. PMID: 20191314.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    30. MicroRNA in the immune system, microRNA as an immune system. Immunology. 2009 Jul; 127(3):291-8. Lu LF, Liston A. PMID: 19538248; PMCID: PMC2712098.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    31. Molecular orchestration of differentiation and function of regulatory T cells. Genes Dev. 2009 Jun 01; 23(11):1270-82. Lu LF, Rudensky A. PMID: 19487568; PMCID: PMC2763538.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    32. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009 Jan 16; 30(1):80-91. Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY. PMID: 19144316; PMCID: PMC2654249.
      View in: PubMed   Mentions: 419     Fields:    Translation:HumansAnimalsCells
    33. Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells. J Immunol. 2008 Oct 01; 181(7):4752-60. Gondek DC, Devries V, Nowak EC, Lu LF, Bennett KA, Scott ZA, Noelle RJ. PMID: 18802078; PMCID: PMC2572718.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    34. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med. 2008 Sep 01; 205(9):1993-2004. Liston A, Lu LF, O'Carroll D, Tarakhovsky A, Rudensky AY. PMID: 18725526; PMCID: PMC2526195.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    35. G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Mol Cell Biol. 2007 Dec; 27(23):8065-72. Lu LF, Gavin MA, Rasmussen JP, Rudensky AY. PMID: 17893329; PMCID: PMC2169173.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    36. The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation. Blood. 2007 Jul 01; 110(1):193-200. Lu LF, Ahonen CL, Lind EF, Raman VS, Cook WJ, Lin LL, Noelle RJ. PMID: 17360936; PMCID: PMC1896113.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    37. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature. 2006 Aug 31; 442(7106):997-1002. Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, Scott ZA, Coyle AJ, Reed JL, Van Snick J, Strom TB, Zheng XX, Noelle RJ. PMID: 16921386.
      View in: PubMed   Mentions: 320     Fields:    Translation:AnimalsCells
    38. NF kappa B-inducing kinase deficiency results in the development of a subset of regulatory T cells, which shows a hyperproliferative activity upon glucocorticoid-induced TNF receptor family-related gene stimulation. J Immunol. 2005 Aug 01; 175(3):1651-7. Lu LF, Gondek DC, Scott ZA, Noelle RJ. PMID: 16034105.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    39. Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol. 2005 Feb 15; 174(4):1783-6. Gondek DC, Lu LF, Quezada SA, Sakaguchi S, Noelle RJ. PMID: 15699103.
      View in: PubMed   Mentions: 312     Fields:    Translation:AnimalsCells
    40. Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8+ T cells. Cancer Gene Ther. 2004 Feb; 11(2):135-47. Liu KJ, Lu LF, Cheng HT, Hung YM, Shiou SR, Whang-Peng J, Juang SH. PMID: 14647233.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    41. CD40 signaling through a newly identified tumor necrosis factor receptor-associated factor 2 (TRAF2) binding site. J Biol Chem. 2003 Nov 14; 278(46):45414-8. Lu LF, Cook WJ, Lin LL, Noelle RJ. PMID: 12960157.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells