Susan Ferro-Novick

Title(s)Distinguished Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
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    Collapse Overview
    The Ferro-Novick laboratory studies how the directionality and specificity of vesicle traffic between the endoplasmic reticulum and Golgi is achieved and the role that the GTPase Rab1 plays in these events and in autophagy. The laboratory also studies the structure and inheritance of the endoplasmic reticulum.

    Research Focus Areas:

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    The diverse roles of ER-Golgi trafficking machinery in autophagy and ER quality control
    NIH/NIGMS R35GM131681Apr 1, 2019 - Mar 31, 2024
    Role: Principal Investigator
    The contribution of the secretory pathway to macroautophagy
    NIH/NIGMS R01GM115422May 1, 2016 - Apr 30, 2020
    Role: Principal Investigator
    The role of a CK1 kinase in membrane traffic
    NIH/NIGMS R01GM114111May 11, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen S, Cui Y, Parashar S, Novick PJ, Ferro-Novick S. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6237-E6244. PMID: 29915089.
      View in: PubMed
    2. Yuan H, Davis S, Ferro-Novick S, Novick P. Rewiring a Rab regulatory network reveals a possible inhibitory role for the vesicle tether, Uso1. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8637-E8645. PMID: 28973856.
      View in: PubMed
    3. Farhan H, Kundu M, Ferro-Novick S. The link between autophagy and secretion: a story of multitasking proteins. Mol Biol Cell. 2017 May 01; 28(9):1161-1164. PMID: 28468940.
      View in: PubMed
    4. Davis S, Wang J, Ferro-Novick S. Crosstalk between the Secretory and Autophagy Pathways Regulates Autophagosome Formation. Dev Cell. 2017 04 10; 41(1):23-32. PMID: 28399396.
      View in: PubMed
    5. Wang J, Davis S, Zhu M, Miller EA, Ferro-Novick S. Autophagosome formation: Where the secretory and autophagy pathways meet. Autophagy. 2017 May 04; 13(5):973-974. PMID: 28287860.
      View in: PubMed
    6. Davis S, Wang J, Zhu M, Stahmer K, Lakshminarayan R, Ghassemian M, Jiang Y, Miller EA, Ferro-Novick S. Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation. Elife. 2016 11 18; 5. PMID: 27855785.
      View in: PubMed
    7. Ding J, Segarra VA, Chen S, Cai H, Lemmon SK, Ferro-Novick S. Auxilin facilitates membrane traffic in the early secretory pathway. Mol Biol Cell. 2016 Jan 01; 27(1):127-36. PMID: 26538028; PMCID: PMC4694752.
    8. Wang J, Davis S, Menon S, Zhang J, Ding J, Cervantes S, Miller E, Jiang Y, Ferro-Novick S. Ypt1/Rab1 regulates Hrr25/CK1d kinase activity in ER-Golgi traffic and macroautophagy. J Cell Biol. 2015 Jul 20; 210(2):273-85. PMID: 26195667; PMCID: PMC4508898.
    9. Casey AK, Chen S, Novick P, Ferro-Novick S, Wente SR. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Mol Biol Cell. 2015 Aug 01; 26(15):2833-44. PMID: 26041935; PMCID: PMC4571342.
    10. Davis S, Ferro-Novick S. Ypt1 and COPII vesicles act in autophagosome biogenesis and the early secretory pathway. Biochem Soc Trans. 2015 Feb; 43(1):92-6. PMID: 25619251.
      View in: PubMed
    11. Wang J, Cervantes S, Davis S, Ferro-Novick S. Identifying a Rab effector on the macroautophagy pathway. Methods Mol Biol. 2015; 1298:117-25. PMID: 25800837.
      View in: PubMed
    12. Chen S, Desai T, McNew JA, Gerard P, Novick PJ, Ferro-Novick S. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):418-23. PMID: 25548161; PMCID: PMC4299238.
    13. Wang J, Tan D, Cai Y, Reinisch KM, Walz T, Ferro-Novick S. A requirement for ER-derived COPII vesicles in phagophore initiation. Autophagy. 2014 Apr; 10(4):708-9. PMID: 24561915; PMCID: PMC4091162.
    14. Ferro-Novick S, Brose N. Nobel 2013 Physiology or medicine: Traffic control system within cells. Nature. 2013 Dec 05; 504(7478):98. PMID: 24305158.
      View in: PubMed
    15. Tan D, Cai Y, Wang J, Zhang J, Menon S, Chou HT, Ferro-Novick S, Reinisch KM, Walz T. The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19432-7. PMID: 24218626; PMCID: PMC3845172.
    16. Li X, Ferro-Novick S, Novick P. Different polarisome components play distinct roles in Slt2p-regulated cortical ER inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2013 Oct; 24(19):3145-54. PMID: 23924898; PMCID: PMC3784387.
    17. Bhandari D, Zhang J, Menon S, Lord C, Chen S, Helm JR, Thorsen K, Corbett KD, Hay JC, Ferro-Novick S. Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits. Mol Biol Cell. 2013 Sep; 24(17):2727-38. PMID: 23864707; PMCID: PMC3756924.
    18. Wang J, Menon S, Yamasaki A, Chou HT, Walz T, Jiang Y, Ferro-Novick S. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9800-5. PMID: 23716696; PMCID: PMC3683756.
    19. Chen S, Novick P, Ferro-Novick S. ER structure and function. Curr Opin Cell Biol. 2013 Aug; 25(4):428-33. PMID: 23478217.
      View in: PubMed
    20. Lord C, Ferro-Novick S, Miller EA. The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi. Cold Spring Harb Perspect Biol. 2013 Feb 01; 5(2). PMID: 23378591; PMCID: PMC3552504.
    21. Chen S, Novick P, Ferro-Novick S. ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. Nat Cell Biol. 2012 Jun 24; 14(7):707-16. PMID: 22729086; PMCID: PMC3389217.
    22. Lee JH, Silhavy JL, Lee JE, Al-Gazali L, Thomas S, Davis EE, Bielas SL, Hill KJ, Iannicelli M, Brancati F, Gabriel SB, Russ C, Logan CV, Sharif SM, Bennett CP, Abe M, Hildebrandt F, Diplas BH, AttiƩ-Bitach T, Katsanis N, Rajab A, Koul R, Sztriha L, Waters ER, Ferro-Novick S, Woods CG, Johnson CA, Valente EM, Zaki MS, Gleeson JG. Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. Science. 2012 Feb 24; 335(6071):966-9. PMID: 22282472.
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    23. Chen S, Cai H, Park SK, Menon S, Jackson CL, Ferro-Novick S. Trs65p, a subunit of the Ypt1p GEF TRAPPII, interacts with the Arf1p exchange factor Gea2p to facilitate COPI-mediated vesicle traffic. Mol Biol Cell. 2011 Oct; 22(19):3634-44. PMID: 21813735; PMCID: PMC3183018.
    24. Lord C, Bhandari D, Menon S, Ghassemian M, Nycz D, Hay J, Ghosh P, Ferro-Novick S. Sequential interactions with Sec23 control the direction of vesicle traffic. Nature. 2011 May 12; 473(7346):181-6. PMID: 21532587; PMCID: PMC3093450.
    25. Barrowman J, Bhandari D, Reinisch K, Ferro-Novick S. TRAPP complexes in membrane traffic: convergence through a common Rab. Nat Rev Mol Cell Biol. 2010 11; 11(11):759-63. PMID: 20966969.
      View in: PubMed
    26. Lynch-Day MA, Bhandari D, Menon S, Huang J, Cai H, Bartholomew CR, Brumell JH, Ferro-Novick S, Klionsky DJ. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7811-6. PMID: 20375281; PMCID: PMC2867920.
    27. Li X, Du Y, Siegel S, Ferro-Novick S, Novick P. Activation of the mitogen-activated protein kinase, Slt2p, at bud tips blocks a late stage of endoplasmic reticulum inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2010 May 15; 21(10):1772-82. PMID: 20357006.
      View in: PubMed
    28. Sclafani A, Chen S, Rivera-Molina F, Reinisch K, Novick P, Ferro-Novick S. Establishing a role for the GTPase Ypt1p at the late Golgi. Traffic. 2010 Apr; 11(4):520-32. PMID: 20059749; PMCID: PMC2861988.
    29. Yamasaki A, Menon S, Yu S, Barrowman J, Meerloo T, Oorschot V, Klumperman J, Satoh A, Ferro-Novick S. mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles. Mol Biol Cell. 2009 Oct; 20(19):4205-15. PMID: 19656848.
      View in: PubMed
    30. Chin HF, Cai Y, Menon S, Ferro-Novick S, Reinisch KM, De La Cruz EM. Kinetic analysis of the guanine nucleotide exchange activity of TRAPP, a multimeric Ypt1p exchange factor. J Mol Biol. 2009 Jun 05; 389(2):275-88. PMID: 19361519; PMCID: PMC2770256.
    31. Cai Y, Chin HF, Lazarova D, Menon S, Fu C, Cai H, Sclafani A, Rodgers DW, De La Cruz EM, Ferro-Novick S, Reinisch KM. The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell. 2008 Jun 27; 133(7):1202-13. PMID: 18585354.
      View in: PubMed
    32. Cai H, Reinisch K, Ferro-Novick S. Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev Cell. 2007 May; 12(5):671-82. PMID: 17488620.
      View in: PubMed
    33. Cai H, Yu S, Menon S, Cai Y, Lazarova D, Fu C, Reinisch K, Hay JC, Ferro-Novick S. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Nature. 2007 Feb 22; 445(7130):941-4. PMID: 17287728.
      View in: PubMed
    34. Menon S, Cai H, Lu H, Dong G, Cai Y, Reinisch K, Ferro-Novick S. mBET3 is required for the organization of the TRAPP complexes. Biochem Biophys Res Commun. 2006 Nov 24; 350(3):669-77. PMID: 17027922.
      View in: PubMed
    35. Du Y, Walker L, Novick P, Ferro-Novick S. Ptc1p regulates cortical ER inheritance via Slt2p. EMBO J. 2006 Oct 04; 25(19):4413-22. PMID: 16977319; PMCID: PMC1589985.
    36. Yu S, Satoh A, Pypaert M, Mullen K, Hay JC, Ferro-Novick S. mBet3p is required for homotypic COPII vesicle tethering in mammalian cells. J Cell Biol. 2006 Jul 31; 174(3):359-68. PMID: 16880271; PMCID: PMC2064232.
    37. De Craene JO, Coleman J, Estrada de Martin P, Pypaert M, Anderson S, Yates JR, Ferro-Novick S, Novick P. Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell. 2006 Jul; 17(7):3009-20. PMID: 16624861.
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    38. Estrada de Martin P, Novick P, Ferro-Novick S. The organization, structure, and inheritance of the ER in higher and lower eukaryotes. Biochem Cell Biol. 2005 Dec; 83(6):752-61. PMID: 16333327.
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    39. Cai H, Zhang Y, Pypaert M, Walker L, Ferro-Novick S. Mutants in trs120 disrupt traffic from the early endosome to the late Golgi. J Cell Biol. 2005 Dec 05; 171(5):823-33. PMID: 16314430; PMCID: PMC2171297.
    40. Estrada de Martin P, Du Y, Novick P, Ferro-Novick S. Ice2p is important for the distribution and structure of the cortical ER network in Saccharomyces cerevisiae. J Cell Sci. 2005 Jan 01; 118(Pt 1):65-77. PMID: 15585575.
      View in: PubMed
    41. Wiederkehr A, De Craene JO, Ferro-Novick S, Novick P. Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. J Cell Biol. 2004 Dec 06; 167(5):875-87. PMID: 15583030; PMCID: PMC2172455.
    42. Du Y, Ferro-Novick S, Novick P. Dynamics and inheritance of the endoplasmic reticulum. J Cell Sci. 2004 Jun 15; 117(Pt 14):2871-8. PMID: 15197242.
      View in: PubMed
    43. Estrada P, Kim J, Coleman J, Walker L, Dunn B, Takizawa P, Novick P, Ferro-Novick S. Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae. J Cell Biol. 2003 Dec 22; 163(6):1255-66. PMID: 14691136; PMCID: PMC2173705.
    44. Wiederkehr A, Du Y, Pypaert M, Ferro-Novick S, Novick P. Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum. Mol Biol Cell. 2003 Dec; 14(12):4770-82. PMID: 12960429.
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    45. Barrowman J, Wang W, Zhang Y, Ferro-Novick S. The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles. J Biol Chem. 2003 May 30; 278(22):19878-84. PMID: 12657649.
      View in: PubMed
    46. Wang W, Ferro-Novick S. A Ypt32p exchange factor is a putative effector of Ypt1p. Mol Biol Cell. 2002 Sep; 13(9):3336-43. PMID: 12221137; PMCID: PMC124163.