Saptarshi Sinha

Title(s)Assistant Project Scientist, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. 5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex. Expert Opin Ther Targets. 2026 Jul; 30(7):785-802. Paul S, Das C, Bhal S, Sinha S, Dash SR, Acharya SS, Goswami A, Goutam K, Kundu CN, Parija T. PMID: 42466612.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. COMPASS enables cohort-independent digital biomarker discovery and pathway quantification. bioRxiv. 2026 Jun 14. Sinha S, Ghosh P. PMID: 41573865; PMCID: PMC12822815.
      View in: PubMed   Mentions:
    3. A stromal-state dichotomy governs recalcitrance or remission in inflammatory bowel disease. bioRxiv. 2026 Jun 13. Tindle C, Penrose HM, Sinha S, Mullick M, Carpio-Perkins K, Hayashi M, Carpinelli SS, McLaren E, Hsieh CC, Zablan K, Le HN, Neill J, Katkar GD, Sandborn WJ, Boland BS, Ghosh P. PMID: 42146514; PMCID: PMC13174420.
      View in: PubMed   Mentions:
    4. An Endocytic Checkpoint Controls Macrophage PD-1 Function and Immunotherapy Fate. bioRxiv. 2026 Apr 17. Mullick M, McLaren E, Roy S, Biagas B, Anandachar MS, Castillo V, Williams S, Espinoza CR, Tindle C, Katkar GD, Thistlethwaite PA, Sinha S, Ghosh P. PMID: 42039661; PMCID: PMC13104919.
      View in: PubMed   Mentions:
    5. A NOD2-Encoded Toggle Switch Resolves the Host-Microbe Battle Over Cyclic AMP Control. bioRxiv. 2026 Mar 31. Anandachar MS, Chen D, Perkins KC, Katkar GD, Roy S, Espinoza CR, Mullick M, Sinha S, Nakayama M, Salem J, Estanol M, Bhattacharjee R, Zablan K, Hsu ST, Williams S, Sun A, Tindle C, Yang J, Kufareva I, Ghosh P. PMID: 41959225; PMCID: PMC13060301.
      View in: PubMed   Mentions:
    6. A Druggable G Protein Checkpoint in Cholesterol Efflux. bioRxiv. 2026 Feb 17. Katkar GD, Anandachar MS, Espinoza CR, Estanol M, Biggs C, Nacayama M, Tam E, Mukharjee R, McLaren E, Aviles S, Castillo V, Mullick M, Yang J, Kaufmann B, Sinha S, Ghosh P. PMID: 41757070; PMCID: PMC12934564.
      View in: PubMed   Mentions:
    7. New approach methodologies in Crohn's disease link molecular disease subtypes to clinical outcomes. Am J Physiol Gastrointest Liver Physiol. 2026 Mar 01; 330(3):G322-G329. Penrose HM, Sinha S, Tindle C, Zablan K, Le HN, Neill J, Ghosh P, Boland BS. PMID: 41665110; PMCID: PMC13008478.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. CANDiT: A machine learning framework for differentiation therapy in colorectal cancer. Cell Rep Med. 2025 Nov 18; 6(11):102421. Sinha S, Alcantara J, Perry K, Castillo V, Ondersma AK, Banerjee S, McLaren E, Espinoza CR, Taheri S, Vidales E, Tindle C, Adel A, Amirfakhri S, Sawires JR, Yang J, Bouvet M, Ghosh P. PMID: 41118768; PMCID: PMC12711679.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Distinct colitis-associated macrophages drive NOD2-dependent bacterial sensing and gut homeostasis. J Clin Invest. 2025 12 01; 135(23). Katkar GD, Anandachar MS, Ibeawuchi SC, McLaren EG, Estanol ML, Carpio-Perkins K, Hsu ST, Espinoza CR, Coates JE, Malhotra YS, Mullick M, Castillo V, Vo D, Sinha S, Ghosh P. PMID: 41321314; PMCID: PMC12646664.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Nootropic benzothiazoles promote dendritic spine formation by targeting fascin-1. J Biol Chem. 2025 09; 301(9):110572. Shivkumar A, Berg KR, Sibucao KC, Leriche G, Dozier LE, Espinoza CA, Patrick GN, Gaieb Z, Seitz C, Amaro RE, Park HH, Hoe HS, Wozniak J, Gonzalez DJ, Sinha S, Ghosh P, Yang J. PMID: 40784448; PMCID: PMC12926044.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. Distinct Colitis-Associated Macrophages Drive NOD2-Dependent Bacterial Sensing and Gut Homeostasis. bioRxiv. 2025 Jul 31. Katkar GD, Anandachar MS, Ibeawuchi SR, McLaren E, Estanol M, Carpio-Perkins K, Hsu ST, Espinoza CR, Coates J, Malhotra YS, Mullick M, Castillo V, Vo DT, Sinha S, Ghosh P. PMID: 40766554; PMCID: PMC12324400.
      View in: PubMed   Mentions:
    12. Machine Learning-Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers. bioRxiv. 2025 Jul 09. Sinha S, Alcantara J, Perry K, Castillo V, Ondersma A, Banerjee S, McLaren E, Espinoza CR, Taheri S, Vidales E, Tindle C, Adel A, Amirfakhri S, Sawires JR, Yang J, Bouvet M, Ghosh P. PMID: 37745574; PMCID: PMC10515918.
      View in: PubMed   Mentions:
    13. A Living Organoid Biobank of Crohn's Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes. medRxiv. 2025 Jul 09. Penrose HM, Sinha S, Tindle C, Zablan K, Le HN, Neill J, Ghosh P, Boland BS. PMID: 40236416; PMCID: PMC11998810.
      View in: PubMed   Mentions:
    14. F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery. bioRxiv. 2025 Apr 30. Sinha S, McLaren E, Mullick M, Penrose HM, Tindle C, Singh S, Boland BS, Ghosh P. PMID: 39071297; PMCID: PMC11275938.
      View in: PubMed   Mentions:
    15. Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels. J Clin Invest. 2024 10 31; 134(24). Sinha S, Callow BW, Farfel AP, Roy S, Chen S, Masotti M, Rajendran S, Buschhaus JM, Espinoza CR, Luker KE, Ghosh P, Luker GD. PMID: 39480488; PMCID: PMC11645149.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    16. Breast Cancers That Disseminate to Bone Marrow Acquire Aggressive Phenotypes through CX43-related Tumor-Stroma Tunnels. bioRxiv. 2024 Aug 10. Sinha S, Callow BW, Farfel AP, Roy S, Chen S, Rajendran S, Buschhaus JM, Espinoza CR, Luker KE, Ghosh P, Luker GD. PMID: 36993616; PMCID: PMC10055300.
      View in: PubMed   Mentions:
    17. Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers. JCI Insight. 2024 07 11; 9(16). Cuello HA, Sinha S, Verhagen AL, Varki N, Varki A, Ghosh P. PMID: 38990656; PMCID: PMC11343606.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of p21. Med Oncol. 2024 Jun 04; 41(7):167. Bhal S, Das B, Sinha S, Das C, Acharya SS, Maji J, Kundu CN. PMID: 38831079.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Growth factor-dependent phosphorylation of Gαi shapes canonical signaling by G protein-coupled receptors. Sci Signal. 2024 06 04; 17(839):eade8041. Roy S, Sinha S, Silas AJ, Ghassemian M, Kufareva I, Ghosh P. PMID: 38833528; PMCID: PMC11328959.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-19 pandemic (MIP-C). EBioMedicine. 2024 Jun; 104:105136. David P, Sinha S, Iqbal K, De Marco G, Taheri S, McLaren E, Maisuria S, Arumugakani G, Ash Z, Buckley C, Coles L, Hettiarachchi C, Payne E, Savic S, Smithson G, Slade M, Shah R, Marzo-Ortega H, Keen M, Lawson C, Mclorinan J, Nizam S, Reddy H, Sharif O, Sultan S, Tran G, Wood M, Wood S, Ghosh P, McGonagle D. PMID: 38723554; PMCID: PMC11090026.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsPHPublic Health
    21. Interlinked switch circuits of biological intelligence. Trends Biochem Sci. 2024 04; 49(4):286-289. Mukherjee R, Sinha S, Luker GD, Ghosh P. PMID: 38341333; PMCID: PMC13277709.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    22. Growth signaling autonomy in circulating tumor cells aids metastatic seeding. PNAS Nexus. 2024 Feb; 3(2):pgae014. Sinha S, Farfel A, Luker KE, Parker BA, Yeung KT, Luker GD, Ghosh P. PMID: 38312224; PMCID: PMC10833458.
      View in: PubMed   Mentions: 3  
    23. MDA5-autoimmunity and Interstitial Pneumonitis Contemporaneous with the COVID-19 Pandemic (MIP-C). medRxiv. 2023 Nov 05. Iqbal K, Sinha S, David P, De Marco G, Taheri S, McLaren E, Maisuria S, Arumugakani G, Ash Z, Buckley C, Coles L, Hettiarachchi C, Smithson G, Slade M, Shah R, Marzo-Ortega H, Keen M, Lawson C, Mclorinan J, Nizam S, Reddy H, Sharif O, Sultan S, Tran G, Wood M, Wood S, Ghosh P, McGonagle D. PMID: 37961408; PMCID: PMC10635254.
      View in: PubMed   Mentions:
    24. Diverse gut pathogens exploit the host engulfment pathway via a conserved mechanism. J Biol Chem. 2023 12; 299(12):105390. Anandachar MS, Roy S, Sinha S, Boadi A, Katkar GD, Ghosh P. PMID: 37890785; PMCID: PMC10696401.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    25. The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine. Life Sci Alliance. 2023 11; 6(11). Hernandez JE, Llorente C, Ma S, Miyamoto KT, Sinha S, Steele S, Xiao Z, Lai CJ, Zuniga EI, Ghosh P, Schnabl B, Huang WJM. PMID: 37666668; PMCID: PMC10477432.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Diverse Gut Pathogens Exploit the Host Engulfment Pathway via a Conserved Mechanism. bioRxiv. 2023 Aug 27. Anandachar MS, Roy S, Sinha S, Agyekum B, Ibeawuchi SR, Gementera H, Amamoto A, Katkar GD, Ghosh P. PMID: 37066267; PMCID: PMC10104235.
      View in: PubMed   Mentions:
    27. Machine learning identifies signatures of macrophage reactivity and tolerance that predict disease outcomes. EBioMedicine. 2023 Aug; 94:104719. Ghosh P, Sinha S, Katkar GD, Vo D, Taheri S, Dang D, Das S, Sahoo D. PMID: 37516087; PMCID: PMC10388732.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells. Phytomedicine. 2023 Aug; 117:154914. Das B, Dash SR, Patel H, Sinha S, Bhal S, Paul S, Das C, Pradhan R, Ahmed I, Goutam K, Kundu CN. PMID: 37321076.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Near-infrared enhances antiangiogenic potentiality of quinacrine-gold hybrid nanoparticles in breast cancer stem cells via deregulation of HSP-70/TGF-β. Nanomedicine (Lond). 2023 01; 18(1):19-33. Dash SR, Das B, Das C, Sinha S, Paul S, Pradhan R, Kundu CN. PMID: 36916388.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. A circuit for secretion-coupled cellular autonomy in multicellular eukaryotic cells. Mol Syst Biol. 2023 04 12; 19(4):e11127. Qiao L, Sinha S, Abd El-Hafeez AA, Lo IC, Midde KK, Ngo T, Aznar N, Lopez-Sanchez I, Gupta V, Farquhar MG, Rangamani P, Ghosh P. PMID: 36856068; PMCID: PMC10090951.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    31. COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis. EBioMedicine. 2022 Aug; 82:104185. Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P. PMID: 35870428; PMCID: PMC9297827.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    32. COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis. bioRxiv. 2022 Jul 18. Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P. PMID: 34873597; PMCID: PMC8647648.
      View in: PubMed   Mentions:
    33. NIR irradiation enhances the apoptotic potentiality of quinacrine-gold hybrid nanoparticles by modulation of HSP-70 in oral cancer stem cells. Nanomedicine. 2022 02; 40:102502. Dash SR, Chatterjee S, Sinha S, Das B, Paul S, Pradhan R, Sethy C, Panda R, Tripathy J, Kundu CN. PMID: 34843984.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
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