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Alexandra Newton

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0721
La Jolla CA 92093
Phone858-534-4527
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Stanford University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanisms of Cell Signaling
    NIH/NIGMS R35GM122523Jun 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    NIH/NIGMS R01GM067946May 1, 2003 - Jul 31, 2015
    Role: Principal Investigator
    PROTEIN KINASE C: STRUCTURE/REGULATION/CELLULAR FUNCTION
    NIH/NCI R13CA085161Feb 7, 2000 - Feb 6, 2001
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
    Role: Co-Investigator
    ON SIGNAL TRANSDUCTION AND LIPID SECOND MESSENGERS
    NIH/NIGMS R13GM057207Mar 1, 1998 - Feb 28, 1999
    Role: Principal Investigator
    PROTEIN KINASE C AND PHOTORECEPTORS
    NIH/NEI R01EY008820Aug 1, 1991 - Feb 28, 2004
    Role: Principal Investigator
    Structure, Function and Regulation of Protein Kinase C
    NIH/NIGMS R01GM043154Dec 1, 1989 - May 31, 2017
    Role: Principal Investigator
    Structure, Function and Regulation of Protein Kinase C
    NIH/NIGMS R37GM043154Dec 1, 1989 - Aug 31, 2013
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    EFFECT OF ACTIVATION ON MEMBRANE-BOUND PROTEIN KINASE C
    NIH/NIGMS F32GM011356Feb 14, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC. Protein kinase Ca gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation. Proc Natl Acad Sci U S A. 2018 May 29. PMID: 29844158.
      View in: PubMed
    2. Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P. Genetic code expansion and live cell imaging reveal that Thr308 phosphorylation is irreplaceable and sufficient for Akt1 activity. J Biol Chem. 2018 May 17. PMID: 29773654.
      View in: PubMed
    3. Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, Kannan N. Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. Sci Rep. 2018 Apr 25; 8(1):6518. PMID: 29695735.
      View in: PubMed
    4. Newton AC. Protein kinase C: perfectly balanced. Crit Rev Biochem Mol Biol. 2018 Apr; 53(2):208-230. PMID: 29513138.
      View in: PubMed
    5. Newton AC. Protein kinase C as a tumor suppressor. Semin Cancer Biol. 2018 Feb; 48:18-26. PMID: 28476658.
      View in: PubMed
    6. Newton AC, Brognard J. Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. Trends Pharmacol Sci. 2017 05; 38(5):438-447. PMID: 28283201.
      View in: PubMed
    7. Grzechnik AT, Newton AC. PHLPPing through history: a decade in the life of PHLPP phosphatases. Biochem Soc Trans. 2016 12 15; 44(6):1675-1682. PMID: 27913677.
      View in: PubMed
    8. McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyers PA, Kannan N. KinView: a visual comparative sequence analysis tool for integrated kinome research. Mol Biosyst. 2016 11 15; 12(12):3651-3665. PMID: 27731453.
      View in: PubMed
    9. Newton AC, Antal CE, Steinberg SF. Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond). 2016 09 01; 130(17):1499-510. PMID: 27433023; PMCID: PMC5024564.
    10. Newton AC, Bootman MD, Scott JD. Second Messengers. Cold Spring Harb Perspect Biol. 2016 Aug 01; 8(8). PMID: 27481708.
      View in: PubMed
    11. Scott JD, Newton AC. Bacterial spore coat protein kinases: A new twist to an old story. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):6811-2. PMID: 27286827; PMCID: PMC4922189 [Available on 12/21/16].
    12. Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Raza Ali S, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJ, Nizet V. Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem. 2016 Jul 01; 291(27):13964-73. PMID: 27226531; PMCID: PMC4933157 [Available on 07/01/17].
    13. Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Gain-of-function mutations in protein kinase Ca (PKCa) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016 05 10; 9(427):ra47. PMID: 27165780.
      View in: PubMed
    14. Newton AC, Tanzi RE, VanHook AM. Science Signaling Podcast for 10 May 2016: PKCa in Alzheimer's disease. Sci Signal. 2016 May 10; 9(427):pc11. PMID: 27165779.
      View in: PubMed
    15. Tobias IS, Newton AC. Protein Scaffolds Control Localized Protein Kinase C? Activity. J Biol Chem. 2016 Jun 24; 291(26):13809-22. PMID: 27143478; PMCID: PMC4919463 [Available on 06/24/17].
    16. Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA. Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. Oncotarget. 2016 Apr 12; 7(15):20919-33. PMID: 26989024; PMCID: PMC4991501.
    17. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC. Protein kinase C? exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J. 2016 Feb 15; 473(4):509-23. PMID: 26635352; PMCID: PMC4888060.
    18. Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C ßII. Cell Rep. 2015 Aug 25; 12(8):1252-60. PMID: 26279568; PMCID: PMC4551583.
    19. Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 04; 290(36):21845-56. PMID: 26187466; PMCID: PMC4571940.
    20. Bradley EW, Carpio LR, Newton AC, Westendorf JJ. Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. J Biol Chem. 2015 Jun 26; 290(26):16272-80. PMID: 25953896; PMCID: PMC4481226.
    21. Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):E937-46. PMID: 25713130; PMCID: PMC4352799.
    22. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29; 160(3):489-502. PMID: 25619690; PMCID: PMC4313737.
    23. Kunkel MT, Newton AC. Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. Chem Biol. 2015 Jan 22; 22(1):98-106. PMID: 25556943; PMCID: PMC4311772.
    24. Antal CE, Newton AC. Tuning the signalling output of protein kinase C. Biochem Soc Trans. 2014 Dec; 42(6):1477-83. PMID: 25399557.
      View in: PubMed
    25. Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E3957-65. PMID: 25201979; PMCID: PMC4183331.
    26. Sierecki E, Newton AC. Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase. Biochemistry. 2014 Jun 24; 53(24):3971-81. PMID: 24892992; PMCID: PMC4072346.
    27. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 08; 54(3):378-91. PMID: 24703948; PMCID: PMC4019712.
    28. Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. Intramolecular conformational changes optimize protein kinase C signaling. Chem Biol. 2014 Apr 24; 21(4):459-469. PMID: 24631122; PMCID: PMC4020788.
    29. Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE. Protein kinase Cd-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem. 2014 Mar 28; 289(13):8781-98. PMID: 24500718; PMCID: PMC3979370.
    30. Newton AC, Trotman LC. Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol. 2014; 54:537-58. PMID: 24392697; PMCID: PMC4082184.
    31. Kunkel MT, Newton AC. Imaging kinase activity at protein scaffolds. Methods Mol Biol. 2014; 1071:129-37. PMID: 24052385; PMCID: PMC4043534.
    32. Antal CE, Newton AC. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics. 2013 Dec; 12(12):3498-508. PMID: 23788531; PMCID: PMC3861703.
    33. Wu-Zhang AX, Newton AC. Protein kinase C pharmacology: refining the toolbox. Biochem J. 2013 Jun 01; 452(2):195-209. PMID: 23662807; PMCID: PMC4079666.
    34. Scott AM, Antal CE, Newton AC. Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Ca. J Biol Chem. 2013 Jun 07; 288(23):16905-15. PMID: 23589289; PMCID: PMC3675623.
    35. Wu-Zhang AX, Murphy AN, Bachman M, Newton AC. Isozyme-specific interaction of protein kinase Cd with mitochondria dissected using live cell fluorescence imaging. J Biol Chem. 2012 Nov 02; 287(45):37891-906. PMID: 22988234; PMCID: PMC3488061.
    36. de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chem Biol. 2012 Aug 24; 19(8):994-1000. PMID: 22921066; PMCID: PMC4079670.
    37. Scott JD, Newton AC. Shedding light on local kinase activation. BMC Biol. 2012 Jul 17; 10:61. PMID: 22805055; PMCID: PMC3398854.
    38. O'Neill AK, Niederst MJ, Newton AC. Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J. 2013 Jan; 280(2):572-83. PMID: 22340730; PMCID: PMC3770140.
    39. Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC. Cellular pharmacology of protein kinase M? (PKM?) contrasts with its in vitro profile: implications for PKM? as a mediator of memory. J Biol Chem. 2012 Apr 13; 287(16):12879-85. PMID: 22378786; PMCID: PMC3339930.
    40. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. PMID: 22318721; PMCID: PMC3339987.
    41. Warfel NA, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. J Biol Chem. 2012 Feb 03; 287(6):3610-6. PMID: 22144674; PMCID: PMC3281723.
    42. O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton AC. Protein kinase Ca promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011 Dec 16; 286(50):43559-68. PMID: 22027822; PMCID: PMC3234831.
    43. Warfel NA, Niederst M, Newton AC. Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. J Biol Chem. 2011 Nov 11; 286(45):39122-9. PMID: 21908613; PMCID: PMC3234737.
    44. Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, Carver BS, Trotman LC. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 2011 Aug 16; 20(2):173-86. PMID: 21840483; PMCID: PMC3176728.
    45. Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. J Biol Chem. 2011 Sep 23; 286(38):33390-400. PMID: 21795686; PMCID: PMC3190922.
    46. Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC. Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem. 2011 Aug 19; 286(33):28922-30. PMID: 21715334; PMCID: PMC3190699.
    47. Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem. 2011 Jul 01; 286(26):23552-8. PMID: 21561857; PMCID: PMC3123118.
    48. Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol. 2011 May 15; 186(10):5533-7. PMID: 21498666; PMCID: PMC4015973.
    49. Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. Mislocalization of the E3 ligase, ß-transducin repeat-containing protein 1 (ß-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem. 2011 Jun 03; 286(22):19777-88. PMID: 21454620; PMCID: PMC3103356.
    50. Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci. 2011 Feb 09; 31(6):2113-24. PMID: 21307248; PMCID: PMC3097059.
    51. Gallegos LL, Newton AC. Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. Methods Mol Biol. 2011; 756:295-310. PMID: 21870234; PMCID: PMC4048020.
    52. Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton AC. Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. J Biol Chem. 2010 Dec 31; 285(53):41896-910. PMID: 20959447; PMCID: PMC3009917.
    53. Sierecki E, Sinko W, McCammon JA, Newton AC. Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem. 2010 Oct 14; 53(19):6899-911. PMID: 20836557; PMCID: PMC2951065.
    54. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. PMID: 20576936; PMCID: PMC2957297.
    55. Kunkel MT, Newton AC. Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes. J Biol Chem. 2010 Jul 23; 285(30):22748-52. PMID: 20519514; PMCID: PMC2906264.
    56. Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010 Feb 26; 37(4):541-50. PMID: 20188672; PMCID: PMC3014287.
    57. Masubuchi S, Gao T, O'Neill A, Eckel-Mahan K, Newton AC, Sassone-Corsi P. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1642-7. PMID: 20080691; PMCID: PMC2824391.
    58. Kunkel MT, Newton AC. Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters. Curr Protoc Chem Biol. 2009 Dec 01; 1(1):17-18. PMID: 21804950.
      View in: PubMed
    59. Newton AC. Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E395-402. PMID: 19934406; PMCID: PMC2838521.
    60. Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. J Biol Chem. 2009 Sep 04; 284(36):24653-61. PMID: 19581308; PMCID: PMC2782054.
    61. Brognard J, Niederst M, Reyes G, Warfel N, Newton AC. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. J Biol Chem. 2009 May 29; 284(22):15215-23. PMID: 19324870; PMCID: PMC2685702.
    62. Gould CM, Kannan N, Taylor SS, Newton AC. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem. 2009 Feb 20; 284(8):4921-35. PMID: 19091746; PMCID: PMC2643500.
    63. Gallegos LL, Newton AC. Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. IUBMB Life. 2008 Dec; 60(12):782-9. PMID: 18720411; PMCID: PMC2718795.
    64. Newton AC. Lipid activation of protein kinases. J Lipid Res. 2009 Apr; 50 Suppl:S266-71. PMID: 19033211; PMCID: PMC2674703.
    65. Newton AC. Protein kinase C. IUBMB Life. 2008 Nov; 60(11):765-8. PMID: 18683875.
      View in: PubMed
    66. Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell. 2008 Oct 24; 32(2):169-79. PMID: 18951085; PMCID: PMC3169907.
    67. Gould CM, Newton AC. The life and death of protein kinase C. Curr Drug Targets. 2008 Aug; 9(8):614-25. PMID: 18691009.
      View in: PubMed
    68. Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23; 27(14):1932-43. PMID: 18566586; PMCID: PMC2486276.
    69. Brognard J, Newton AC. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab. 2008 Aug; 19(6):223-30. PMID: 18511290; PMCID: PMC2963565.
    70. Dries DR, Newton AC. Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy. J Biol Chem. 2008 Mar 21; 283(12):7885-93. PMID: 18187412.
      View in: PubMed
    71. Gao T, Brognard J, Newton AC. The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem. 2008 Mar 07; 283(10):6300-11. PMID: 18162466.
      View in: PubMed
    72. Newton AC, Mochly-Rosen D. Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007). IUBMB Life. 2007 Dec; 59(12):741-3. PMID: 18085473.
      View in: PubMed
    73. Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem. 2007 Nov 16; 282(46):33776-87. PMID: 17893151.
      View in: PubMed
    74. Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007 Mar 23; 25(6):917-31. PMID: 17386267.
      View in: PubMed
    75. Kunkel MT, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem. 2007 Mar 02; 282(9):6733-42. PMID: 17189263; PMCID: PMC2921767.
    76. Dries DR, Gallegos LL, Newton AC. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J Biol Chem. 2007 Jan 12; 282(2):826-30. PMID: 17071619.
      View in: PubMed
    77. Gao T, Newton AC. Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70. J Biol Chem. 2006 Oct 27; 281(43):32461-8. PMID: 16954220.
      View in: PubMed
    78. Gallegos LL, Kunkel MT, Newton AC. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem. 2006 Oct 13; 281(41):30947-56. PMID: 16901905.
      View in: PubMed
    79. Giorgione JR, Lin JH, McCammon JA, Newton AC. Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem. 2006 Jan 20; 281(3):1660-9. PMID: 16293612; PMCID: PMC2913972.
    80. Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005 Apr 01; 18(1):13-24. PMID: 15808505.
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    81. Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem. 2005 Feb 18; 280(7):5581-7. PMID: 15583002; PMCID: PMC2913970.
    82. King CC, Newton AC. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2004 Sep 03; 279(36):37518-27. PMID: 15210700.
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    83. Newton AC. Diacylglycerol's affair with protein kinase C turns 25. Trends Pharmacol Sci. 2004 Apr; 25(4):175-7. PMID: 15116719.
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    84. Violin JD, Newton AC. Pathway illuminated: visualizing protein kinase C signaling. IUBMB Life. 2003 Dec; 55(12):653-60. PMID: 14769001.
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    85. Chen D, Purohit A, Halilovic E, Doxsey SJ, Newton AC. Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. J Biol Chem. 2004 Feb 06; 279(6):4829-39. PMID: 14594954.
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    86. Giorgione J, Hysell M, Harvey DF, Newton AC. Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. Biochemistry. 2003 Sep 30; 42(38):11194-202. PMID: 14503869.
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    87. Adams RA, Liu X, Williams DS, Newton AC. Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J. 2003 Sep 01; 374(Pt 2):537-43. PMID: 12809555; PMCID: PMC1223618.
    88. Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9470-5. PMID: 12881490; PMCID: PMC170942.
    89. Bertolini TM, Giorgione J, Harvey DF, Newton AC. Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions. J Org Chem. 2003 Jun 27; 68(13):5028-36. PMID: 12816455.
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    90. Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol. 2003 Jun 09; 161(5):899-909. PMID: 12782683; PMCID: PMC2172956.
    91. Newton AC. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J. 2003 Mar 01; 370(Pt 2):361-71. PMID: 12495431; PMCID: PMC1223206.
    92. Newton AC. Measuring the interaction of protein kinase C with membranes: an introduction. Methods Mol Biol. 2003; 233:89-92. PMID: 12840500.
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    93. Giorgione J, Newton AC. Measuring the binding of protein kinase C to sucrose-loaded vesicles. Methods Mol Biol. 2003; 233:105-13. PMID: 12840502.
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    94. Nalefski EA, Newton AC. Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C. Methods Mol Biol. 2003; 233:115-28. PMID: 12840503.
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    95. Newton AC. The ins and outs of protein kinase C. Methods Mol Biol. 2003; 233:3-7. PMID: 12840493.
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