Alexandra Newton

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
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    Ph.D.Stanford University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Structural and Molecular Mechanisms for Dysregulation of Protein Kinase C Gamma in Cerebellar Ataxia
    NIH R01NS120725May 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Establishing Function of Understudied PRKCQ Kinase in Cellular Regulation and Disease
    NIH R03TR002914Aug 20, 2019 - Aug 19, 2021
    Role: Principal Investigator
    Molecular Mechanisms of Cell Signaling
    NIH R35GM122523Jun 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Signal Termination by PHLPP, PH domain Leucine-rich repeat Protein Phosphatase
    NIH R01GM067946May 1, 2003 - Jan 31, 2017
    Role: Principal Investigator
    NIH R13CA085161Feb 7, 2000 - Feb 6, 2001
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH P01DK054441Dec 15, 1998 - Mar 31, 2019
    Role: Co-Investigator
    NIH R13GM057207Mar 1, 1998 - Feb 28, 1999
    Role: Principal Investigator
    NIH R01EY008820Aug 1, 1991 - Feb 28, 2004
    Role: Principal Investigator
    Structure, Function and Regulation of Protein Kinase C
    NIH R01GM043154Dec 1, 1989 - May 31, 2017
    Role: Principal Investigator
    Structure, Function and Regulation of Protein Kinase C
    NIH R37GM043154Dec 1, 1989 - Aug 31, 2013
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    NIH F32GM011356Feb 14, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC. bioRxiv. 2024 Mar 30. Su Q, Zhang J, Lin W, Zhang JF, Newton AC, Mehta S, Yang J, Zhang J. PMID: 38586003; PMCID: PMC10996667.
      View in: PubMed   Mentions:
    2. Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput. bioRxiv. 2023 Nov 14. Kennedy PH, Deh Sheikh AA, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer C, Alarcón S, Newby G, Myers SA. PMID: 38014346; PMCID: PMC10680671.
      View in: PubMed   Mentions:
    3. Author Correction: Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol. 2023 Sep; 25(9):1385. Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. PMID: 37580389.
      View in: PubMed   Mentions:    Fields:    
    4. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. Biochem J. 2023 08 30; 480(16):1299-1316. Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. PMID: 37551632; PMCID: PMC10586763.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. bioRxiv. 2023 Mar 16. Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. PMID: 36993163; PMCID: PMC10055082.
      View in: PubMed   Mentions:
    7. Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer. IUBMB Life. 2023 Apr; 75(4):282-283. Newton AC, Alessi DR. PMID: 36905647.
      View in: PubMed   Mentions:    Fields:    
    8. Protein kinase C showcases allosteric control: activation of LRRK1. Biochem J. 2023 02 14; 480(3):219-223. Tovell H, Newton AC. PMID: 36762701; PMCID: PMC9987930.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    9. Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model. Nat Commun. 2022 11 23; 13(1):7200. Lordén G, Wozniak JM, Doré K, Dozier LE, Cates-Gatto C, Patrick GN, Gonzalez DJ, Roberts AJ, Tanzi RE, Newton AC. PMID: 36418293; PMCID: PMC9684486.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    10. Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition. Sci Signal. 2022 Sep 27; 15(753):eabk1147. Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, Newton AC. PMID: 36166510; PMCID: PMC9810342.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration. Front Cell Dev Biol. 2022; 10:929510. Pilo CA, Newton AC. PMID: 35800893; PMCID: PMC9253466.
      View in: PubMed   Mentions: 3  
    12. Protein kinase C: release from quarantine by mTORC2. Trends Biochem Sci. 2022 06; 47(6):518-530. Baffi TR, Newton AC. PMID: 35361526; PMCID: PMC10936736.
      View in: PubMed   Mentions: 7     Fields:    Translation:CellsPHPublic Health
    13. PHLPP Signaling in Immune Cells. Curr Top Microbiol Immunol. 2022; 436:117-143. Lordén G, Lam AJ, Levings MK, Newton AC. PMID: 36243842.
      View in: PubMed   Mentions: 3     Fields:    
    14. Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment? Neuronal Signal. 2021 Dec; 5(4):NS20210036. Lordén G, Newton AC. PMID: 34737895; PMCID: PMC8536831.
      View in: PubMed   Mentions: 8  
    15. mTOR Regulation of AGC Kinases: New Twist to an Old Tail. Mol Pharmacol. 2022 04; 101(4):213-218. Baffi TR, Newton AC. PMID: 34155089; PMCID: PMC9092464.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 04 13; 14(678). Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. PMID: 33850054; PMCID: PMC8208635.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    17. PKCα Is Recruited to Staphylococcus aureus-Containing Phagosomes and Impairs Bacterial Replication by Inhibition of Autophagy. Front Immunol. 2021; 12:662987. Gauron MC, Newton AC, Colombo MI. PMID: 33815423; PMCID: PMC8013776.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. Protein kinase C fusion proteins are paradoxically loss of function in cancer. J Biol Chem. 2021 Jan-Jun; 296:100445. Van AN, Kunkel MT, Baffi TR, Lordén G, Antal CE, Banerjee S, Newton AC. PMID: 33617877; PMCID: PMC8008189.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    19. PHLPPing the balance: restoration of protein kinase C in cancer. Biochem J. 2021 01 29; 478(2):341-355. Tovell H, Newton AC. PMID: 33502516; PMCID: PMC8086891.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    20. The PHLPP1 N-Terminal Extension is a Mitotic Cdk1 Substrate and Controls an Interactome Switch. Mol Cell Biol. 2021 Jan 04. Kawashima AT, Wong C, Lordén G, King CC, Lara-Gonzalez P, Desai A, Gingras AC, Newton AC. PMID: 33397691; PMCID: PMC8088274.
      View in: PubMed   Mentions: 3     Fields:    
    21. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun. 2020 11 30; 11(1):6088. Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. PMID: 33257668; PMCID: PMC7705703.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes. IUBMB Life. 2020 12; 72(12):2584-2590. Jones AC, Taylor SS, Newton AC, Kornev AP. PMID: 33166426; PMCID: PMC8086893.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling. Annu Rev Pharmacol Toxicol. 2021 01 06; 61:723-743. Baffi TR, Cohen-Katsenelson K, Newton AC. PMID: 32997603.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    24. Pharmacology on Target. Trends Pharmacol Sci. 2020 04; 41(4):227-230. Kawashima AT, Newton AC. PMID: 32122673.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    25. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. Elife. 2019 08 13; 8. Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. PMID: 31408005; PMCID: PMC6692130.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    26. The PHLPP2 phosphatase is a druggable driver of prostate cancer progression. J Cell Biol. 2019 06 03; 218(6):1943-1957. Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, Trotman LC. PMID: 31092557; PMCID: PMC6548123.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    27. Protein kinases in tune. IUBMB Life. 2019 06; 71(6):670-671. Newton AC. PMID: 31059207.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer. Mol Cell. 2019 04 18; 74(2):378-392.e5. Baffi TR, Van AN, Zhao W, Mills GB, Newton AC. PMID: 30904392; PMCID: PMC6504549.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    29. Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol. 2019 03; 21(3):359-371. Jung HY, Fattet L, Tsai JH, Kajimoto T, Chang Q, Newton AC, Yang J. PMID: 30804505; PMCID: PMC6546105.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    30. Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter. Sci Signal. 2019 01 01; 12(562). Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, Andrew McCammon J, Nakamura SI, Newton AC. PMID: 30600259; PMCID: PMC6657501.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    31. Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation. Proc Natl Acad Sci U S A. 2018 06 12; 115(24):E5497-E5505. Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC. PMID: 29844158; PMCID: PMC6004447.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity. J Biol Chem. 2018 07 06; 293(27):10744-10756. Balasuriya N, Kunkel MT, Liu X, Biggar KK, Li SS, Newton AC, O'Donoghue P. PMID: 29773654; PMCID: PMC6036199.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    33. Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. Sci Rep. 2018 04 25; 8(1):6518. Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, Kannan N. PMID: 29695735; PMCID: PMC5916945.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    34. Protein kinase C: perfectly balanced. Crit Rev Biochem Mol Biol. 2018 04; 53(2):208-230. Newton AC. PMID: 29513138; PMCID: PMC5901981.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    35. Modelling the role of groundwater hydro-refugia in East African hominin evolution and dispersal. Nat Commun. 2017 05 30; 8:15696. Cuthbert MO, Gleeson T, Reynolds SC, Bennett MR, Newton AC, McCormack CJ, Ashley GM. PMID: 28556825; PMCID: PMC5460002.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    36. Protein kinase C as a tumor suppressor. Semin Cancer Biol. 2018 02; 48:18-26. Newton AC. PMID: 28476658; PMCID: PMC5668200.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    37. Conventional protein kinase C in the brain: 40 years later. Neuronal Signal. 2017 Apr; 1(2):NS20160005. Callender JA, Newton AC. PMID: 32714576; PMCID: PMC7373245.
      View in: PubMed   Mentions: 35  
    38. Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. Trends Pharmacol Sci. 2017 05; 38(5):438-447. Newton AC, Brognard J. PMID: 28283201; PMCID: PMC5403564.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    39. PHLPPing through history: a decade in the life of PHLPP phosphatases. Biochem Soc Trans. 2016 12 15; 44(6):1675-1682. Grzechnik AT, Newton AC. PMID: 27913677; PMCID: PMC5783572.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    40. KinView: a visual comparative sequence analysis tool for integrated kinome research. Mol Biosyst. 2016 11 15; 12(12):3651-3665. McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyers PA, Kannan N. PMID: 27731453; PMCID: PMC5508867.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    41. Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond). 2016 09 01; 130(17):1499-510. Newton AC, Antal CE, Steinberg SF. PMID: 27433023; PMCID: PMC5024564.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    42. Second Messengers. Cold Spring Harb Perspect Biol. 2016 08 01; 8(8). Newton AC, Bootman MD, Scott JD. PMID: 27481708; PMCID: PMC4968160.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    43. Bacterial spore coat protein kinases: A new twist to an old story. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):6811-2. Scott JD, Newton AC. PMID: 27286827; PMCID: PMC4922189.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    44. Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem. 2016 Jul 01; 291(27):13964-13973. Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Raza Ali S, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJP, Nizet V. PMID: 27226531; PMCID: PMC4933157.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    45. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016 05 10; 9(427):ra47. Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. PMID: 27165780; PMCID: PMC5154619.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    46. Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease. Sci Signal. 2016 May 10; 9(427):pc11. Newton AC, Tanzi RE, VanHook AM. PMID: 27165779.
      View in: PubMed   Mentions:    Fields:    
    47. Protein Scaffolds Control Localized Protein Kinase Cζ Activity. J Biol Chem. 2016 Jun 24; 291(26):13809-22. Tobias IS, Newton AC. PMID: 27143478; PMCID: PMC4919463.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    48. Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival. Oncotarget. 2016 Apr 12; 7(15):20919-33. Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA. PMID: 26989024; PMCID: PMC4991501.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    49. Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J. 2016 Feb 15; 473(4):509-23. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC. PMID: 26635352; PMCID: PMC4888060.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    50. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Rep. 2015 Aug 25; 12(8):1252-60. Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. PMID: 26279568; PMCID: PMC4551583.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    51. Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 04; 290(36):21845-56. Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC. PMID: 26187466; PMCID: PMC4571940.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    52. Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. J Biol Chem. 2015 Jun 26; 290(26):16272-80. Bradley EW, Carpio LR, Newton AC, Westendorf JJ. PMID: 25953896; PMCID: PMC4481226.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    53. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):E937-46. Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P. PMID: 25713130; PMCID: PMC4352799.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    54. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29; 160(3):489-502. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. PMID: 25619690; PMCID: PMC4313737.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    55. Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. Chem Biol. 2015 Jan 22; 22(1):98-106. Kunkel MT, Newton AC. PMID: 25556943; PMCID: PMC4311772.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    56. Tuning the signalling output of protein kinase C. Biochem Soc Trans. 2014 Dec; 42(6):1477-83. Antal CE, Newton AC. PMID: 25399557; PMCID: PMC5783555.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    57. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E3957-65. Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC. PMID: 25201979; PMCID: PMC4183331.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    58. Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase. Biochemistry. 2014 Jun 24; 53(24):3971-81. Sierecki E, Newton AC. PMID: 24892992; PMCID: PMC4072346.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    59. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 08; 54(3):378-91. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. PMID: 24703948; PMCID: PMC4019712.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    60. Intramolecular conformational changes optimize protein kinase C signaling. Chem Biol. 2014 Apr 24; 21(4):459-469. Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. PMID: 24631122; PMCID: PMC4020788.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    61. Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem. 2014 Mar 28; 289(13):8781-98. Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE. PMID: 24500718; PMCID: PMC3979370.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    62. Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol. 2014; 54:537-58. Newton AC, Trotman LC. PMID: 24392697; PMCID: PMC4082184.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    63. Imaging kinase activity at protein scaffolds. Methods Mol Biol. 2014; 1071:129-37. Kunkel MT, Newton AC. PMID: 24052385; PMCID: PMC4043534.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    64. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics. 2013 Dec; 12(12):3498-508. Antal CE, Newton AC. PMID: 23788531; PMCID: PMC3861703.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    65. Protein kinase C pharmacology: refining the toolbox. Biochem J. 2013 Jun 01; 452(2):195-209. Wu-Zhang AX, Newton AC. PMID: 23662807; PMCID: PMC4079666.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    66. Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα. J Biol Chem. 2013 Jun 07; 288(23):16905-16915. Scott AM, Antal CE, Newton AC. PMID: 23589289; PMCID: PMC3675623.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    67. Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging. J Biol Chem. 2012 Nov 02; 287(45):37891-906. Wu-Zhang AX, Murphy AN, Bachman M, Newton AC. PMID: 22988234; PMCID: PMC3488061.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    68. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chem Biol. 2012 Aug 24; 19(8):994-1000. de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG. PMID: 22921066; PMCID: PMC4079670.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    69. Shedding light on local kinase activation. BMC Biol. 2012 Jul 17; 10:61. Scott JD, Newton AC. PMID: 22805055; PMCID: PMC3398854.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    70. Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J. 2013 Jan; 280(2):572-83. O'Neill AK, Niederst MJ, Newton AC. PMID: 22340730; PMCID: PMC3770140.
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    71. Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory. J Biol Chem. 2012 Apr 13; 287(16):12879-85. Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC. PMID: 22378786; PMCID: PMC3339930.
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    72. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. PMID: 22318721; PMCID: PMC3339987.
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    73. Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia. 2012 Jul; 26(7):1689-92. O'Hayre M, Niederst M, Fecteau JF, Nguyen VM, Kipps TJ, Messmer D, Newton AC, Handel TM. PMID: 22237780; PMCID: PMC3395972.
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    74. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. J Biol Chem. 2012 Feb 03; 287(6):3610-6. Warfel NA, Newton AC. PMID: 22144674; PMCID: PMC3281723.
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    75. Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011 Dec 16; 286(50):43559-68. O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton AC. PMID: 22027822; PMCID: PMC3234831.
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    76. Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2. J Biol Chem. 2011 Nov 11; 286(45):39122-9. Warfel NA, Niederst M, Newton AC. PMID: 21908613; PMCID: PMC3234737.
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    77. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 2011 Aug 16; 20(2):173-86. Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, Carver BS, Trotman LC. PMID: 21840483; PMCID: PMC3176728.
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    78. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. J Biol Chem. 2011 Sep 23; 286(38):33390-400. Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers DM. PMID: 21795686; PMCID: PMC3190922.
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    79. Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem. 2011 Aug 19; 286(33):28922-28930. Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC. PMID: 21715334; PMCID: PMC3190699.
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    80. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem. 2011 Jul 01; 286(26):23552-8. Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. PMID: 21561857; PMCID: PMC3123118.
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    81. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol. 2011 May 15; 186(10):5533-7. Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK. PMID: 21498666; PMCID: PMC4015973.
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    82. Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem. 2011 Jun 03; 286(22):19777-88. Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC. PMID: 21454620; PMCID: PMC3103356.
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    83. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci. 2011 Feb 09; 31(6):2113-24. Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. PMID: 21307248; PMCID: PMC3097059.
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    84. Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cells. Methods Mol Biol. 2011; 756:295-310. Gallegos LL, Newton AC. PMID: 21870234; PMCID: PMC4048020.
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    85. Protein kinase C {delta}-specific activity reporter reveals agonist-evoked nuclear activity controlled by Src family of kinases. J Biol Chem. 2010 Dec 31; 285(53):41896-910. Kajimoto T, Sawamura S, Tohyama Y, Mori Y, Newton AC. PMID: 20959447; PMCID: PMC3009917.
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    86. Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem. 2010 Oct 14; 53(19):6899-911. Sierecki E, Sinko W, McCammon JA, Newton AC. PMID: 20836557; PMCID: PMC2951065.
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    87. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PMID: 20576936; PMCID: PMC2957297.
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    88. Calcium transduces plasma membrane receptor signals to produce diacylglycerol at Golgi membranes. J Biol Chem. 2010 Jul 23; 285(30):22748-52. Kunkel MT, Newton AC. PMID: 20519514; PMCID: PMC2906264.
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    89. Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010 Feb 26; 37(4):541-50. Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD. PMID: 20188672; PMCID: PMC3014287.
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    90. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1642-7. Masubuchi S, Gao T, O'Neill A, Eckel-Mahan K, Newton AC, Sassone-Corsi P. PMID: 20080691; PMCID: PMC2824391.
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    91. Spatiotemporal Dynamics of Kinase Signaling Visualized by Targeted Reporters. Curr Protoc Chem Biol. 2009 Dec 01; 1(1):17-18. Kunkel MT, Newton AC. PMID: 21804950; PMCID: PMC3146362.
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    92. Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E395-402. Newton AC. PMID: 19934406; PMCID: PMC2838521.
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    93. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. J Biol Chem. 2009 Sep 04; 284(36):24653-61. Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC. PMID: 19581308; PMCID: PMC2782054.
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    94. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. J Biol Chem. 2009 May 29; 284(22):15215-23. Brognard J, Niederst M, Reyes G, Warfel N, Newton AC. PMID: 19324870; PMCID: PMC2685702.
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    95. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem. 2009 Feb 20; 284(8):4921-35. Gould CM, Kannan N, Taylor SS, Newton AC. PMID: 19091746; PMCID: PMC2643500.
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    96. Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm. IUBMB Life. 2008 Dec; 60(12):782-9. Gallegos LL, Newton AC. PMID: 18720411; PMCID: PMC2718795.
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    97. Lipid activation of protein kinases. J Lipid Res. 2009 Apr; 50 Suppl:S266-71. Newton AC. PMID: 19033211; PMCID: PMC2674703.
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    98. Protein kinase C. IUBMB Life. 2008 Nov; 60(11):765-8. Newton AC. PMID: 18683875.
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    99. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell. 2008 Oct 24; 32(2):169-79. Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD. PMID: 18951085; PMCID: PMC3169907.
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    100. The life and death of protein kinase C. Curr Drug Targets. 2008 Aug; 9(8):614-25. Gould CM, Newton AC. PMID: 18691009; PMCID: PMC5783564.
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    101. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23; 27(14):1932-43. Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. PMID: 18566586; PMCID: PMC2486276.
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    102. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab. 2008 Aug; 19(6):223-30. Brognard J, Newton AC. PMID: 18511290; PMCID: PMC2963565.
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    103. Kinetic analysis of the interaction of the C1 domain of protein kinase C with lipid membranes by stopped-flow spectroscopy. J Biol Chem. 2008 Mar 21; 283(12):7885-93. Dries DR, Newton AC. PMID: 18187412.
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    104. The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem. 2008 Mar 07; 283(10):6300-11. Gao T, Brognard J, Newton AC. PMID: 18162466.
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    105. Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007). IUBMB Life. 2007 Dec; 59(12):741-3. Newton AC, Mochly-Rosen D. PMID: 18085473.
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    106. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. J Biol Chem. 2007 Nov 16; 282(46):33776-33787. Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. PMID: 17893151.
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    107. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007 Mar 23; 25(6):917-31. Brognard J, Sierecki E, Gao T, Newton AC. PMID: 17386267.
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    108. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem. 2007 Mar 02; 282(9):6733-42. Kunkel MT, Toker A, Tsien RY, Newton AC. PMID: 17189263; PMCID: PMC2921767.
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    109. A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J Biol Chem. 2007 Jan 12; 282(2):826-30. Dries DR, Gallegos LL, Newton AC. PMID: 17071619.
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    110. Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70. J Biol Chem. 2006 Oct 27; 281(43):32461-8. Gao T, Newton AC. PMID: 16954220.
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    111. Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem. 2006 Oct 13; 281(41):30947-56. Gallegos LL, Kunkel MT, Newton AC. PMID: 16901905.
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    112. Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem. 2006 Jan 20; 281(3):1660-9. Giorgione JR, Lin JH, McCammon JA, Newton AC. PMID: 16293612; PMCID: PMC2913972.
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    113. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005 Apr 01; 18(1):13-24. Gao T, Furnari F, Newton AC. PMID: 15808505.
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    114. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem. 2005 Feb 18; 280(7):5581-7. Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. PMID: 15583002; PMCID: PMC2913970.
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    115. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2004 Sep 03; 279(36):37518-27. King CC, Newton AC. PMID: 15210700.
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    116. Diacylglycerol's affair with protein kinase C turns 25. Trends Pharmacol Sci. 2004 Apr; 25(4):175-7. Newton AC. PMID: 15116719.
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    117. Pathway illuminated: visualizing protein kinase C signaling. IUBMB Life. 2003 Dec; 55(12):653-60. Violin JD, Newton AC. PMID: 14769001.
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    118. Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. J Biol Chem. 2004 Feb 06; 279(6):4829-39. Chen D, Purohit A, Halilovic E, Doxsey SJ, Newton AC. PMID: 14594954.
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    119. Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. Biochemistry. 2003 Sep 30; 42(38):11194-202. Giorgione J, Hysell M, Harvey DF, Newton AC. PMID: 14503869.
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    120. Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J. 2003 Sep 01; 374(Pt 2):537-43. Adams RA, Liu X, Williams DS, Newton AC. PMID: 12809555; PMCID: PMC1223618.
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    121. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9470-5. Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T. PMID: 12881490; PMCID: PMC170942.
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    122. Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions. J Org Chem. 2003 Jun 27; 68(13):5028-36. Bertolini TM, Giorgione J, Harvey DF, Newton AC. PMID: 12816455.
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    123. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol. 2003 Jun 09; 161(5):899-909. Violin JD, Zhang J, Tsien RY, Newton AC. PMID: 12782683; PMCID: PMC2172956.
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    124. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J. 2003 Mar 01; 370(Pt 2):361-71. Newton AC. PMID: 12495431; PMCID: PMC1223206.
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    125. Measuring the interaction of protein kinase C with membranes: an introduction. Methods Mol Biol. 2003; 233:89-92. Newton AC. PMID: 12840500.
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    126. Measuring the binding of protein kinase C to sucrose-loaded vesicles. Methods Mol Biol. 2003; 233:105-13. Giorgione J, Newton AC. PMID: 12840502.
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    127. Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C. Methods Mol Biol. 2003; 233:115-28. Nalefski EA, Newton AC. PMID: 12840503.
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    128. The ins and outs of protein kinase C. Methods Mol Biol. 2003; 233:3-7. Newton AC. PMID: 12840493.
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    129. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem. 2002 Aug 30; 277(35):31585-92. Gao T, Newton AC. PMID: 12080070.
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    130. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science. 2002 May 03; 296(5569):913-6. Zacharias DA, Violin JD, Newton AC, Tsien RY. PMID: 11988576.
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    131. PKA, PKC, and AKAP localization in and around the neuromuscular junction. BMC Neurosci. 2001; 2:17. Perkins GA, Wang L, Huang LJ, Humphries K, Yao VJ, Martone M, Deerinck TJ, Barraclough DM, Violin JD, Smith D, Newton A, Scott JD, Taylor SS, Ellisman MH. PMID: 11716788; PMCID: PMC59892.
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    132. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev. 2001 Aug; 101(8):2353-64. Newton AC. PMID: 11749377.
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    133. The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA. J Biol Chem. 2001 Sep 21; 276(38):35794-801. Newton A, Mackay J, Crossley M. PMID: 11445591.
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    134. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. J Biol Chem. 2001 Jun 01; 276(22):19588-96. Gao T, Toker A, Newton AC. PMID: 11376011.
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    135. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem. 2000 Dec 29; 275(52):41201-9. King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM. PMID: 10995762.
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    136. Solution structures of two CCHC zinc fingers from the FOG family protein U-shaped that mediate protein-protein interactions. Structure. 2000 Nov 15; 8(11):1157-66. Liew CK, Kowalski K, Fox AH, Newton A, Sharpe BK, Crossley M, Mackay JP. PMID: 11080638.
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    137. Cellular signaling: pivoting around PDK-1. Cell. 2000 Oct 13; 103(2):185-8. Toker A, Newton AC. PMID: 11057891.
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    138. The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain. Biochemistry. 2000 Sep 19; 39(37):11360-9. Johnson JE, Giorgione J, Newton AC. PMID: 10985781.
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    139. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol. 2000 Sep; 279(3):L429-38. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. PMID: 10956616.
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    140. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. J Biol Chem. 2000 Jun 16; 275(24):18108-13. King CC, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch GM. PMID: 10748151.
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    141. Dual role of pseudosubstrate in the coordinated regulation of protein kinase C by phosphorylation and diacylglycerol. J Biol Chem. 2000 Apr 07; 275(14):10697-701. Dutil EM, Newton AC. PMID: 10744767.
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    142. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 2000 Apr; 85(3):395-404. Granados-Soto V, Kalcheva I, Hua XY, Newton A, Yaksh TL. PMID: 10781912.
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    143. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem. 2000 Mar 24; 275(12):8271-4. Toker A, Newton AC. PMID: 10722653.
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    144. A novel bacterial tyrosine kinase essential for cell division and differentiation. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13068-73. Wu J, Ohta N, Zhao JL, Newton A. PMID: 10557274; PMCID: PMC23901.
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    145. Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction. Biochem J. 1999 Oct 15; 343 Pt 2:443-52. Faux MC, Rollins EN, Edwards AS, Langeberg LK, Newton AC, Scott JD. PMID: 10510312; PMCID: PMC1220573.
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    146. The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Curr Biol. 1999 Jul 15; 9(14):728-37. Behn-Krappa A, Newton AC. PMID: 10421574.
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    147. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. J Biol Chem. 1999 Mar 05; 274(10):6461-8. Edwards AS, Faux MC, Scott JD, Newton AC. PMID: 10037738.
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    148. Mechanism of the apparent cooperativity in the interaction of protein kinase C with phosphatidylserine. Biochemistry. 1998 Dec 08; 37(49):17271-9. Mosior M, Newton AC. PMID: 9860841.
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    149. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol. 1998 Dec 17-31; 8(25):1366-75. Dutil EM, Toker A, Newton AC. PMID: 9889098.
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    150. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol. 1998 Sep 24; 8(19):1069-77. Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A. PMID: 9768361.
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    151. Protected-site phosphorylation of protein kinase C in hippocampal long-term potentiation. J Neurochem. 1998 Sep; 71(3):1075-85. Sweatt JD, Atkins CM, Johnson J, English JD, Roberson ED, Chen SJ, Newton A, Klann E. PMID: 9721732.
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    152. Lipid structure and not membrane structure is the major determinant in the regulation of protein kinase C by phosphatidylserine. Biochemistry. 1998 Sep 01; 37(35):12020-5. Johnson JE, Zimmerman ML, Daleke DL, Newton AC. PMID: 9724512.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    153. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. Biochim Biophys Acta. 1998 Aug 21; 1376(2):155-72. Newton AC, Johnson JE. PMID: 9748550.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    154. Regulation of the phosphorylation state of rhodopsin by dopamine. J Biol Chem. 1998 Mar 27; 273(13):7181-4. Udovichenko IP, Newton AC, Williams DS. PMID: 9516406.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    155. An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1443-8. Wu J, Ohta N, Newton A. PMID: 9465034; PMCID: PMC19037.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    156. Regulation of protein kinase C betaII by its C2 domain. Biochemistry. 1997 Dec 16; 36(50):15615-23. Edwards AS, Newton AC. PMID: 9398289.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    157. A putative phosphatidylserine binding motif is not involved in the lipid regulation of protein kinase C. J Biol Chem. 1997 Dec 05; 272(49):30787-92. Johnson JE, Edwards AS, Newton AC. PMID: 9388219.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    158. Requirement of topoisomerase IV parC and parE genes for cell cycle progression and developmental regulation in Caulobacter crescentus. Mol Microbiol. 1997 Dec; 26(5):897-910. Ward D, Newton A. PMID: 9426128.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    159. Ca2+ differentially regulates conventional protein kinase Cs' membrane interaction and activation. J Biol Chem. 1997 Oct 10; 272(41):25959-67. Keranen LM, Newton AC. PMID: 9325330.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    160. Characterization of protein kinase C in photoreceptor outer segments. J Neurochem. 1997 Oct; 69(4):1693-702. Williams DS, Liu X, Schlamp CL, Ondek B, Jaken S, Newton AC. PMID: 9326298.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    161. Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C. J Biol Chem. 1997 Jul 18; 272(29):18382-90. Edwards AS, Newton AC. PMID: 9218480.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    162. Identification of protein kinase C phosphorylation sites on bovine rhodopsin. J Biol Chem. 1997 Apr 18; 272(16):10341-4. Greene NM, Williams DS, Newton AC. PMID: 9099669.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    163. Regulation of protein kinase C. Curr Opin Cell Biol. 1997 Apr; 9(2):161-7. Newton AC. PMID: 9069266.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansAnimalsCells
    164. Identification, characterization, and chromosomal organization of cell division cycle genes in Caulobacter crescentus. J Bacteriol. 1997 Apr; 179(7):2169-80. Ohta N, Ninfa AJ, Allaire A, Kulick L, Newton A. PMID: 9079901; PMCID: PMC178952.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    165. Contribution of protein kinase C to the phosphorylation of rhodopsin in intact retinas. J Biol Chem. 1997 Mar 21; 272(12):7952-9. Udovichenko IP, Newton AC, Williams DS. PMID: 9065465.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    166. Taxonomy and function of C1 protein kinase C homology domains. Protein Sci. 1997 Feb; 6(2):477-80. Hurley JH, Newton AC, Parker PJ, Blumberg PM, Nishizuka Y. PMID: 9041654; PMCID: PMC2143645.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    167. Inhibition of the insulin receptor tyrosine kinase by phosphatidic acid. J Cell Biochem. 1996 Sep 15; 62(4):516-28. Arnold RS, Newton AC. PMID: 8891897.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    168. Protein kinase C: ports of anchor in the cell. Curr Biol. 1996 Jul 01; 6(7):806-9. Newton AC. PMID: 8805297.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    169. Isolation, identification, and transcriptional specificity of the heat shock sigma factor sigma32 from Caulobacter crescentus. J Bacteriol. 1996 Apr; 178(7):2094-101. Wu J, Newton A. PMID: 8606189; PMCID: PMC177910.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    170. Diacylglycerol directly stimulates the insulin receptor tyrosine kinase. FEBS Lett. 1996 Feb 12; 380(1-2):58-62. Arnold RS, Newton AC. PMID: 8603747.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    171. Calcium-independent binding to interfacial phorbol esters causes protein kinase C to associate with membranes in the absence of acidic lipids. Biochemistry. 1996 Feb 06; 35(5):1612-23. Mosior M, Newton AC. PMID: 8634293.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    172. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol. 1995 Dec 01; 5(12):1394-1403. Keranen LM, Dutil EM, Newton AC. PMID: 8749392.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    173. Protein kinase C: structure, function, and regulation. J Biol Chem. 1995 Dec 01; 270(48):28495-8. Newton AC. PMID: 7499357.
      View in: PubMed   Mentions: 381     Fields:    Translation:Cells
    174. Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov; 177(21):6223-9. Hecht GB, Newton A. PMID: 7592388; PMCID: PMC177463.
      View in: PubMed   Mentions: 77     Fields:    Translation:Cells
    175. Mechanism of interaction of protein kinase C with phorbol esters. Reversibility and nature of membrane association. J Biol Chem. 1995 Oct 27; 270(43):25526-33. Mosior M, Newton AC. PMID: 7592722.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    176. Protein kinase C. Seeing two domains. Curr Biol. 1995 Sep 01; 5(9):973-6. Newton AC. PMID: 8542286.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    177. An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus. EMBO J. 1995 Aug 15; 14(16):3915-24. Hecht GB, Lane T, Ohta N, Sommer JM, Newton A. PMID: 7664732; PMCID: PMC394470.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    178. Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C. J Biol Chem. 1995 Mar 24; 270(12):6710-7. Greene NM, Williams DS, Newton AC. PMID: 7896814.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    179. Isozyme-specific inhibition of protein kinase C by RNA aptamers. J Biol Chem. 1994 Dec 23; 269(51):32051-4. Conrad R, Keranen LM, Ellington AD, Newton AC. PMID: 7528207.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    180. In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation. J Biol Chem. 1994 Nov 25; 269(47):29359-62. Dutil EM, Keranen LM, DePaoli-Roach AA, Newton AC. PMID: 7961910.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    181. Requirement for negative charge on "activation loop" of protein kinase C. J Biol Chem. 1994 Nov 04; 269(44):27715-8. Orr JW, Newton AC. PMID: 7961692.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    182. Information essential for cell-cycle-dependent secretion of the 591-residue Caulobacter hook protein is confined to a 21-amino-acid sequence near the N-terminus. Mol Microbiol. 1994 Oct; 14(1):73-85. Kornacker MG, Newton A. PMID: 7830563.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    183. Protein kinase C association with the retinal cytoskeleton and phosphorylation of vimentin. Exp Eye Res. 1994 Jun; 58(6):747-59. Williams DS, Park S, Schlamp CL, Newton AC. PMID: 7925714.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    184. Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes. Biochemistry. 1994 May 31; 33(21):6651-8. Newton AC, Keranen LM. PMID: 8204602.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    185. Intrapeptide regulation of protein kinase C. J Biol Chem. 1994 Mar 18; 269(11):8383-7. Orr JW, Newton AC. PMID: 8132562.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    186. Protein kinase C as a measure of transbilayer phosphatidylserine asymmetry. Anal Biochem. 1994 Feb 15; 217(1):33-40. Daleke DL, Huestis WH, Newton AC. PMID: 8203737.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    187. Gene expression of the neuropeptide-processing enzyme carboxypeptidase E in rat photoreceptor cells. J Neurochem. 1993 Nov; 61(5):1891-900. Nickells RW, Schlamp CL, Newton AC, Williams DS. PMID: 7693871.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    188. Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors. J Biol Chem. 1993 Aug 25; 268(24):18181-6. Newton AC, Williams DS. PMID: 8349693.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    189. Does protein kinase C play a role in rhodopsin desensitization? Trends Biochem Sci. 1993 Aug; 18(8):275-7. Newton AC, Williams DS. PMID: 8236436.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    190. Interaction of proteins with lipid headgroups: lessons from protein kinase C. Annu Rev Biophys Biomol Struct. 1993; 22:1-25. Newton AC. PMID: 8347986.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    191. A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10297-301. Ohta N, Lane T, Ninfa EG, Sommer JM, Newton A. PMID: 1438215; PMCID: PMC50325.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    192. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. J Biol Chem. 1992 Aug 05; 267(22):15263-6. Orr JW, Keranen LM, Newton AC. PMID: 1639770.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    193. Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding. Biochemistry. 1992 May 19; 31(19):4661-7. Orr JW, Newton AC. PMID: 1581316.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    194. Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation. Biochemistry. 1992 May 19; 31(19):4667-73. Orr JW, Newton AC. PMID: 1581317.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    195. Cell cycle regulation in bacteria. Curr Opin Cell Biol. 1992 Apr; 4(2):180-5. Newton A, Ohta N. PMID: 1599688.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    196. Involvement of protein kinase C in the phosphorylation of rhodopsin. J Biol Chem. 1991 Sep 25; 266(27):17725-8. Newton AC, Williams DS. PMID: 1917916.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    197. Inhibition of the insulin receptor tyrosine kinase by sphingosine. Biochemistry. 1991 Aug 06; 30(31):7747-54. Arnold RS, Newton AC. PMID: 1651108.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    198. Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation. Biochemistry. 1990 Jul 17; 29(28):6656-61. Newton AC, Koshland DE. PMID: 2397206.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    199. High cooperativity, specificity, and multiplicity in the protein kinase C-lipid interaction. J Biol Chem. 1989 Sep 05; 264(25):14909-15. Newton AC, Koshland DE. PMID: 2768246.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    200. Vesicle-to-cell protein transfer: insertion of band 3, the erythrocyte anion transporter, into lymphoid cells. Biochemistry. 1988 Jun 28; 27(13):4655-9. Newton AC, Huestis WH. PMID: 3167008.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    201. Lymphoma-vesicle interactions: vesicle adsorption, membrane fragmentation, and intermembrane protein transfer. Biochemistry. 1988 Jun 28; 27(13):4645-55. Newton AC, Huestis WH. PMID: 3167007.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    202. Protein kinase C autophosphorylates by an intrapeptide reaction. J Biol Chem. 1987 Jul 25; 262(21):10185-8. Newton AC, Koshland DE. PMID: 3611058.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    203. Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry. 1987 May 19; 26(10):2886-93. Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE, Cole RD. PMID: 3111527.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    204. Efflux of dipicolinic acid from human erythrocytes, sealed membrane fragments, and band 3-liposome complexes: a fluorescence probe for the erythrocyte anion transporter. Anal Biochem. 1986 Jul; 156(1):56-60. Newton AC, Huestis WH. PMID: 3740418.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    205. Transfer of band 3, the erythrocyte anion transporter, between phospholipid vesicles and cells. Biochemistry. 1983 Dec 20; 22(26):6110-7. Newton AC, Cook SL, Huestis WH. PMID: 6661430.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    206. Regulation of periodic protein synthesis in the cell cycle: control of initiation and termination of flagellar gene expression. Cell. 1981 Apr; 24(1):49-57. Sheffery M, Newton A. PMID: 7237543.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    207. Regulation of flagellin synthesis in the cell cycle of caulobacter: dependence on DNA replication. Cell. 1977 Oct; 12(2):393-400. Osley MA, Sheffery M, Newton A. PMID: 912749.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    208. A pool size problem associated with the use of tritiated thymidine. Nature. 1962 Jun 02; 194:886-7. NEWTON A, DENDY PP, SMITH CL, WILDY P. PMID: 14479357.
      View in: PubMed   Mentions: 7     Fields:    
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