Zoran Radic

Title(s)Associate Adjunct Professor, School of Pharmacy and Pharmaceutical Science
SchoolHealth Sciences
Address9500 Gilman Drive #0751
La Jolla CA 92093
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    Collapse Biography 
    Collapse Awards and Honors
    Croatian Society of Natural Sciences2016  - 2017Spiridion Brusina Medal
    New York Academy of Science2016  - 2020Professional Member

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    Dr. Radic is a graduate of the University of Zagreb in Croatia where he started his research in acetylcholinesterase (AChE) reaction kinetics under mentorship of late Dr. Elsa Reiner, one of founding contributors in the field of cholinesterases. His interests in the AChE molecular structure brought him to the laboratory of Dr. Palmer Taylor at UCSD where he provided key contributions to functional mapping of the AChE molecule using site directed mutagenesis and defined structural domains and amino acid residues critical for catalytic activity and ligand interaction. He was the first to propose common, simplified kinetic scheme and equation to describe acetylcholine (ACh) turnover by both AChE and its structurally and functionally close relative butyrylcholinesterase (BChE) that included both substrate inhibition of AChE and substrate activation of BChE, two prominent forms of deviation from Michaelis-Menten kinetcs. Later this scheme and mechanism proved useful for the description of oxime reactivation kinetics of nerve agent organophosphate (OP) and OP pesticide conjugated AChE and BChE including positive allosteric modulation in reactivation of OP-BChE and negative allosteric modulation of OP-AChE conjugates. Dr. Radic developed intrinsic tryptophane fluorescence based assays as a highly valuable tool for in vitro monitoring of time resolved and equilibrium interactions of cholinergic ligands with native nicotinic acetylcholine receptor ligand binding domain surrogates, ACh binding proteins (AChBPs), as well as with AChE and BChE. This assay proved essential in functional characterization of one of tightest known, high affinity binding small molecule femtomolar AChE inhibitors developed in collaboration with Dr. Barry Sharpless of The Scripps Research Institute in La Jolla (TSRI). Dr. Radic leads, as a PI, NIH funded international collaborative project with researchers from TSRI (Dr. Barry K. Sharpless and Dr. Valery Fokin) and Institute for Medical Research and Occupational Health in Zagreb, Croatia (Dr. Zrinka Kovarik) towards development of novel, improved oxime reactivators of OP-AChE and OP-BChE conjugates, both in vitro and in vivo.

    Collapse Research 
    Collapse Research Activities and Funding
    Overlay independent X-ray data analysis for enhanced oxime OP-ChE reactivation
    NIH/NINDS R21NS098998Sep 30, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Accelerated AChE Reactivator Design by Mechanistic Neutron Scattering Studies
    NIH/NINDS U01NS083451Jul 15, 2014 - Jun 30, 2019
    Role: Principal Investigator
    BChE reactivators for nerve agent and pesticide OP detoxification in human tissue
    NIH/NINDS R21NS084904Sep 30, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Optimization of nonpyridinium oximes for BChE hydrolysis of OPs in plasma
    NIH/NINDS R21NS072086Sep 30, 2010 - Aug 31, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. J Biol Chem. 2020 Mar 27; 295(13):4079-4092. Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z. PMID: 32019865.
      View in: PubMed   Mentions:    Fields:    
    2. Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases. Toxicol Lett. 2020 Mar 15; 321:83-89. Macek Hrvat N, Kalisiak J, Šinko G, Radic Z, Sharpless KB, Taylor P, Kovarik Z. PMID: 31863869.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies. Chem Biol Interact. 2019 Aug 25; 309:108698. Gerlits O, Ho KY, Cheng X, Blumenthal D, Taylor P, Kovalevsky A, Radic Z. PMID: 31176713.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. J Biol Chem. 2019 07 05; 294(27):10607-10618. Gerlits O, Kong X, Cheng X, Wymore T, Blumenthal DK, Taylor P, Radic Z, Kovalevsky A. PMID: 31138650.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase. Toxicol Appl Pharmacol. 2019 06 01; 372:40-46. Kovarik Z, Macek Hrvat N, Kalisiak J, Katalinic M, Sit RK, Zorbaz T, Radic Z, Fokin VV, Sharpless KB, Taylor P. PMID: 30978400.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. Chemistry. 2019 Mar 15; 25(16):4100-4114. Kovarik Z, Kalisiak J, Hrvat NM, Katalinic M, Zorbaz T, Žunec S, Green C, Radic Z, Fokin VV, Sharpless KB, Taylor P. PMID: 30458057.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure. J Pharmacol Exp Ther. 2018 11; 367(2):363-372. Sit RK, Kovarik Z, Macek Hrvat N, Žunec S, Green C, Fokin VV, Sharpless KB, Radic Z, Taylor P. PMID: 30190337.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity. Arch Toxicol. 2018 Mar; 92(3):1161-1176. Hagstrom D, Zhang S, Ho A, Tsai ES, Radic Z, Jahromi A, Kaj KJ, He Y, Taylor P, Collins ES. PMID: 29167930.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor. Chem Biol Interact. 2017 Aug 25; 274:50-57. Rosenberg YJ, Mao L, Jiang X, Lees J, Zhang L, Radic Z, Taylor P. PMID: 28693885.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    10. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Arch Toxicol. 2017 Aug; 91(8):2837-2847. Hagstrom D, Hirokawa H, Zhang L, Radic Z, Taylor P, Collins ES. PMID: 27990564.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    11. Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning. Ann N Y Acad Sci. 2016 08; 1378(1):41-49. Kovalevsky A, Blumenthal DK, Cheng X, Taylor P, Radic Z. PMID: 27371941.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Mechanistic studies of new oximes reactivators of human butyryl cholinesterase inhibited by cyclosarin and sarin. J Biomol Struct Dyn. 2017 May; 35(6):1272-1282. de Lima WE, Francisco A, da Cunha EF, Radic Z, Taylor P, França TC, Ramalho TC. PMID: 27125569.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. Chem Biol Interact. 2016 Nov 25; 259(Pt B):148-153. Macek Hrvat N, Žunec S, Taylor P, Radic Z, Kovarik Z. PMID: 27083141.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Butyrylcholinesterase identification in a phenylvalerate esterase-enriched fraction sensitive to low mipafox concentrations in chicken brain. Arch Toxicol. 2017 Feb; 91(2):909-919. Mangas I, Radic Z, Taylor P, Ghassemian M, Candela H, Vilanova E, Estévez J. PMID: 26838044.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    15. Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal a7 from Muscle a1(2)ß?d nAChRs. Structure. 2015 Jun 02; 23(6):1106-15. Bourne Y, Sulzenbacher G, Radic Z, Aráoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgó J, Taylor P, Marchot P. PMID: 26004441.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    16. Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes. Chem Res Toxicol. 2015 May 18; 28(5):1036-44. Kovarik Z, Macek Hrvat N, Katalinic M, Sit RK, Paradyse A, Žunec S, Musilek K, Fokin VV, Taylor P, Radic Z. PMID: 25835984.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    17. Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system. Toxicol Appl Pharmacol. 2015 Apr 15; 284(2):197-203. Schmidt HR, Radic Z, Taylor P, Fradinger EA. PMID: 25701203.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10749-54. Kaczanowska K, Harel M, Radic Z, Changeux JP, Finn MG, Taylor P. PMID: 25006260.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. J Med Chem. 2014 Feb 27; 57(4):1378-89. Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radic Z. PMID: 24571195.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    20. Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity. PLoS One. 2013; 8(6):e67446. Geng L, Gao Y, Chen X, Hou S, Zhan CG, Radic Z, Parks RJ, Russell SJ, Pham L, Brimijoin S. PMID: 23840704.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    21. Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase. J Chem Inf Model. 2013 Apr 22; 53(4):898-906. Morris GM, Green LG, Radic Z, Taylor P, Sharpless KB, Olson AJ, Grynszpan F. PMID: 23451944.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes. Biochem J. 2013 Feb 15; 450(1):231-42. Radic Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Duggan BM, Ajami D, Rebek J, Taylor P. PMID: 23216060.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    23. Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chem Biol Interact. 2013 Mar 25; 203(1):77-80. Kovarik Z, Macek N, Sit RK, Radic Z, Fokin VV, Barry Sharpless K, Taylor P. PMID: 22960624.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates. Chem Biol Interact. 2013 Mar 25; 203(1):67-71. Radic Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P. PMID: 22975155.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. J Biol Chem. 2012 Apr 06; 287(15):11798-809. Radic Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Fokin VV, Sharpless KB, Taylor P. PMID: 22343626.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    26. Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. J Biol Chem. 2011 Aug 26; 286(34):29718-24. Cochran R, Kalisiak J, Küçükkilinç T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P. PMID: 21730071.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    27. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther. 2011 Jul; 338(1):125-33. Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih PA, Rao F, O'Connor DT, Taylor P. PMID: 21493754.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases. J Biol Chem. 2011 Jun 03; 286(22):19422-30. Sit RK, Radic Z, Gerardi V, Zhang L, Garcia E, Katalinic M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P. PMID: 21464125.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    29. Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state. J Am Chem Soc. 2010 Dec 29; 132(51):18292-300. Bourne Y, Radic Z, Taylor P, Marchot P. PMID: 21090615.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase. Chem Biol Interact. 2010 Sep 06; 187(1-3):163-6. Radic Z, Kalisiak J, Fokin VV, Sharpless KB, Taylor P. PMID: 20412789.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation. Chem Biol Interact. 2010 Sep 06; 187(1-3):238-40. Küçükkilinç T, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radic Z, Taylor P. PMID: 20382137.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    32. Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):6076-81. Bourne Y, Radic Z, Aráoz R, Talley TT, Benoit E, Servent D, Taylor P, Molgó J, Marchot P. PMID: 20224036.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    33. Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7606-11. Talley TT, Harel M, Hibbs RE, Radic Z, Tomizawa M, Casida JE, Taylor P. PMID: 18477694.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    34. Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chem Biol Interact. 2008 Sep 25; 175(1-3):161-5. Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. PMID: 18555981.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    35. Acetylcholinesterase: mechanisms of covalent inhibition of H447I mutant determined by computational analyses. Chem Biol Interact. 2008 Sep 25; 175(1-3):196-9. Cheng YH, Cheng XL, Radic Z, McCammon JA. PMID: 18657802.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. The cholinesterases: analysis by pharmacogenomics in man. Chem Biol Interact. 2008 Sep 25; 175(1-3):343-5. Valle AM, Radic Z, Rana BK, Whitfield JB, O'Connor DT, Martin NG, Taylor P. PMID: 18541229.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectors. Arh Hig Rada Toksikol. 2007 Sep; 58(3):339-45. Taylor P, Reiner E, Kovarik Z, Radic Z. PMID: 17913689.
      View in: PubMed   Mentions: 3     Fields:    
    38. Mechanisms of organophosphate toxicity and detoxication with emphasis on studies in Croatia. Arh Hig Rada Toksikol. 2007 Sep; 58(3):329-38. Reiner E, Radic Z, Simeon-Rudolf V. PMID: 17913688.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    39. Acetylcholinesterase: mechanisms of covalent inhibition of wild-type and H447I mutant determined by computational analyses. J Am Chem Soc. 2007 May 23; 129(20):6562-70. Cheng Y, Cheng X, Radic Z, McCammon JA. PMID: 17461584.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    40. Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins. Biochemistry. 2007 Mar 20; 46(11):3338-55. Kang TS, Radic Z, Talley TT, Jois SD, Taylor P, Kini RM. PMID: 17315952.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    41. Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models. Biophys Chem. 2007 May; 127(3):129-39. Cheng Y, Suen JK, Radic Z, Bond SD, Holst MJ, McCammon JA. PMID: 17307283.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    42. Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure. Toxicology. 2007 Apr 20; 233(1-3):70-8. Taylor P, Kovarik Z, Reiner E, Radic Z. PMID: 17196318.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    43. Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein. J Biol Chem. 2006 Dec 22; 281(51):39708-18. Hibbs RE, Radic Z, Taylor P, Johnson DA. PMID: 17068341.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    44. Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates. Toxicology. 2007 Apr 20; 233(1-3):79-84. Kovarik Z, Radic Z, Berman HA, Taylor P. PMID: 17046138.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    45. Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. J Biol Chem. 2006 Sep 29; 281(39):29256-67. Bourne Y, Radic Z, Sulzenbacher G, Kim E, Taylor P, Marchot P. PMID: 16837465.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    46. Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP. Biochem Biophys Res Commun. 2006 Apr 14; 342(3):973-8. Kovarik Z, Ciban N, Radic Z, Simeon-Rudolf V, Taylor P. PMID: 16598855.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    47. Conformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesterase. Biophys J. 2006 May 01; 90(9):3280-7. Bui JM, Radic Z, Taylor P, McCammon JA. PMID: 16473897.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    48. A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family. J Biol Chem. 2006 Apr 07; 281(14):9667-76. De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor P. PMID: 16434405.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    49. Ligand-induced conformational changes in residues flanking the active site gorge of acetylcholinesterase. Chem Biol Interact. 2005 Dec 15; 157-158:413-4. Pezzementi L, Shi J, Johnson DA, Radic Z, Boyd A, Taylor P. PMID: 16429560.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    50. Acetylcholinesterase mutants: oxime-assisted catalytic scavengers of organophosphonates. Chem Biol Interact. 2005 Dec 15; 157-158:388-90. Kovarik Z, Radic Z, Simeon-Rudolf V, Reiner E, Taylor P. PMID: 16429526.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    51. Species-related differences in the oxime-induced reactivation of organophosphate-inhibited acetylcholinesterases. Chem Biol Interact. 2005 Dec 15; 157-158:393-4. Luo C, Dawson M, Chambers C, Chilukuri N, Radic Z, Taylor P, Doctor BP, Saxena A. PMID: 16429528.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    52. Molecular basis of interactions of cholinesterases with tight binding inhibitors. Chem Biol Interact. 2005 Dec 15; 157-158:133-41. Radic Z, Manetsch R, Krasinski A, Raushel J, Yamauchi J, Garcia C, Kolb H, Sharpless KB, Taylor P. PMID: 16289416.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    53. Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE. Chem Biol Interact. 2005 Dec 15; 157-158:159-65. Bourne Y, Radic Z, Kolb HC, Sharpless KB, Taylor P, Marchot P. PMID: 16259971.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    54. In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. J Am Chem Soc. 2005 May 11; 127(18):6686-92. Krasinski A, Radic Z, Manetsch R, Raushel J, Taylor P, Sharpless KB, Kolb HC. PMID: 15869290.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    55. Tetrameric mouse acetylcholinesterase: continuum diffusion rate calculations by solving the steady-state Smoluchowski equation using finite element methods. Biophys J. 2005 Mar; 88(3):1659-65. Zhang D, Suen J, Zhang Y, Song Y, Radic Z, Taylor P, Holst MJ, Bajaj C, Baker NA, McCammon JA. PMID: 15626705.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    56. In situ click chemistry: enzyme inhibitors made to their own specifications. J Am Chem Soc. 2004 Oct 13; 126(40):12809-18. Manetsch R, Krasinski A, Radic Z, Raushel J, Taylor P, Sharpless KB, Kolb HC. PMID: 15469276.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    57. Contemporary paradigms for cholinergic ligand design guided by biological structure. Bioorg Med Chem Lett. 2004 Apr 19; 14(8):1875-7. Taylor P, Hansen SB, Talley TT, Hibbs RE, Radic Z. PMID: 15050619.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    58. Nanosecond dynamics of acetylcholinesterase near the active center gorge. J Biol Chem. 2004 Jun 18; 279(25):26612-8. Boyd AE, Dunlop CS, Wong L, Radic Z, Taylor P, Johnson DA. PMID: 15078872.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    59. Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica. J Biol Chem. 2004 Jun 04; 279(23):24197-202. Hansen SB, Talley TT, Radic Z, Taylor P. PMID: 15069068.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    60. Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates. Biochemistry. 2004 Mar 23; 43(11):3222-9. Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. PMID: 15023072.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    61. Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1449-54. Bourne Y, Kolb HC, Radic Z, Sharpless KB, Taylor P, Marchot P. PMID: 14757816.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    62. Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases. Eur J Biochem. 2003 Nov; 270(22):4447-58. Saxena A, Fedorko JM, Vinayaka CR, Medhekar R, Radic Z, Taylor P, Lockridge O, Doctor BP. PMID: 14622273.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    63. Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase. Biochem Pharmacol. 2003 Aug 01; 66(3):387-92. Luo C, Leader H, Radic Z, Maxwell DM, Taylor P, Doctor BP, Saxena A. PMID: 12907237.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    64. Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates. Biochem J. 2003 Jul 01; 373(Pt 1):33-40. Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. PMID: 12665427.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    65. Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site. EMBO J. 2003 Jan 02; 22(1):1-12. Bourne Y, Taylor P, Radic Z, Marchot P. PMID: 12505979.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    66. Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. Angew Chem Int Ed Engl. 2002 Mar 15; 41(6):1053-7. Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB. PMID: 12491310.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    67. Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates. J Appl Toxicol. 2001 Dec; 21 Suppl 1:S13-4. Radic Z, Taylor P. PMID: 11920914.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    68. Reversibly bound and covalently attached ligands induce conformational changes in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase. J Biol Chem. 2001 Nov 09; 276(45):42196-204. Shi J, Boyd AE, Radic Z, Taylor P. PMID: 11517229.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    69. Interaction kinetics of reversible inhibitors and substrates with acetylcholinesterase and its fasciculin 2 complex. J Biol Chem. 2001 Feb 16; 276(7):4622-33. Radic Z, Taylor P. PMID: 11036076.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    70. Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis. Biochemistry. 2000 May 16; 39(19):5750-7. Wong L, Radic Z, Brüggemann RJ, Hosea N, Berman HA, Taylor P. PMID: 10801325.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    71. Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity. Chem Biol Interact. 1999 May 14; 119-120:3-15. Taylor P, Wong L, Radic Z, Tsigelny I, Brüggemann R, Hosea NA, Berman HA. PMID: 10421434.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    72. The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases. Chem Biol Interact. 1999 May 14; 119-120:111-7. Radic Z, Taylor P. PMID: 10421444.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    73. Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge. Biopolymers. 1998 Dec; 46(7):465-74. Tara S, Elcock AH, Kirchhoff PD, Briggs JM, Radic Z, Taylor P, McCammon JA. PMID: 9838872.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    74. Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin. J Biol Chem. 1997 Sep 12; 272(37):23265-77. Radic Z, Kirchhoff PD, Quinn DM, McCammon JA, Taylor P. PMID: 9287336.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    75. Expression and activity of mutants of fasciculin, a peptidic acetylcholinesterase inhibitor from mamba venom. J Biol Chem. 1997 Feb 07; 272(6):3502-10. Marchot P, Prowse CN, Kanter J, Camp S, Ackermann EJ, Radic Z, Bougis PE, Taylor P. PMID: 9013597.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    76. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer. 1997; 2(3-4):249-60. Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. PMID: 9676269.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    77. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry. 1996 Aug 20; 35(33):10995-1004. Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. PMID: 8718893.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    78. Structural bases for the specificity of cholinesterase catalysis and inhibition. Toxicol Lett. 1995 Dec; 82-83:453-8. Taylor P, Radic Z, Hosea NA, Camp S, Marchot P, Berman HA. PMID: 8597093.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    79. Allosteric control of acetylcholinesterase catalysis by fasciculin. J Biol Chem. 1995 Sep 01; 270(35):20391-9. Radic Z, Quinn DM, Vellom DC, Camp S, Taylor P. PMID: 7657613.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    80. Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase. Protein Sci. 1995 Apr; 4(4):703-15. van den Born HK, Radic Z, Marchot P, Taylor P, Tsigelny I. PMID: 7613468.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    81. Expression and ligand specificity of acetylcholinesterase and the nicotinic receptor: a tale of two cholinergic sites. Biochem Soc Trans. 1994 Aug; 22(3):740-5. Taylor P, Radic Z, Kreienkamp HJ, Maeda R, Luo Z, Fuentes ME, Vellom D, Pickering N. PMID: 7821676.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    82. Site of fasciculin interaction with acetylcholinesterase. J Biol Chem. 1994 Apr 15; 269(15):11233-9. Radic Z, Duran R, Vellom DC, Li Y, Cervenansky C, Taylor P. PMID: 8157652.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    83. The cholinesterases: from genes to proteins. Annu Rev Pharmacol Toxicol. 1994; 34:281-320. Taylor P, Radic Z. PMID: 8042853.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    84. Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors. Biochemistry. 1993 Nov 16; 32(45):12074-84. Radic Z, Pickering NA, Vellom DC, Camp S, Taylor P. PMID: 8218285.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    85. Structure and regulation of expression of the acetylcholinesterase gene. Chem Biol Interact. 1993 Jun; 87(1-3):199-207. Taylor P, Li Y, Camp S, Rachinsky TL, Ekström T, Getman D, Fuentes ME, Vellom DC, Radic Z. PMID: 8343976.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    86. Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity. Biochemistry. 1993 Jan 12; 32(1):12-7. Vellom DC, Radic Z, Li Y, Pickering NA, Camp S, Taylor P. PMID: 8418833.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    87. Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants. Biochemistry. 1992 Oct 13; 31(40):9760-7. Radic Z, Gibney G, Kawamoto S, MacPhee-Quigley K, Bongiorno C, Taylor P. PMID: 1356436.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    88. Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives. Mol Pharmacol. 1991 Jan; 39(1):98-104. Radic Z, Reiner E, Taylor P. PMID: 1987454.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    89. Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action. Mol Pharmacol. 1989 Sep; 36(3):349-54. Abramson SN, Radic Z, Manker D, Faulkner DJ, Taylor P. PMID: 2779521.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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