Zoran Radic

Title(s)Recall Faculty, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Awards and Honors
    Croatian Society of Natural Sciences2016  - 2017Spiridion Brusina Medal
    New York Academy of Science2016  - 2020Professional Member

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    Dr. Radić is a graduate of the University of Zagreb in Croatia where he started his research in acetylcholinesterase (AChE) reaction kinetics under mentorship of late Dr. Elsa Reiner, one of founding contributors in the field of cholinesterases. His interests in the AChE molecular structure brought him to the laboratory of Dr. Palmer Taylor at UCSD where he provided key contributions to functional mapping of the AChE molecule using site directed mutagenesis and defined structural domains and amino acid residues critical for catalytic activity and ligand interaction. He was the first to propose common, simplified kinetic scheme and equation to describe acetylcholine (ACh) turnover by both AChE and its structurally and functionally close relative butyrylcholinesterase (BChE) that included both substrate inhibition of AChE and substrate activation of BChE, two prominent forms of deviation from Michaelis-Menten kinetcs. Later this scheme and mechanism proved useful for the description of oxime reactivation kinetics of nerve agent organophosphate (OP) and OP pesticide conjugated AChE and BChE including positive allosteric modulation in reactivation of OP-BChE and negative allosteric modulation of OP-AChE conjugates. Dr. Radić developed intrinsic tryptophane fluorescence based assays as a highly valuable tool for in vitro monitoring of time resolved and equilibrium interactions of cholinergic ligands with native nicotinic acetylcholine receptor ligand binding domain surrogates, ACh binding proteins (AChBPs), as well as with AChE and BChE. This assay proved essential in functional characterization of one of tightest known, high affinity binding small molecule femtomolar AChE inhibitors developed in collaboration with Dr. Barry Sharpless of The Scripps Research Institute in La Jolla (TSRI). Dr. Radić leads, as a PI, NIH funded international collaborative project with researchers from TSRI (Dr. Barry K. Sharpless and Dr. Valery Fokin) and Institute for Medical Research and Occupational Health in Zagreb, Croatia (Dr. Zrinka Kovarik) towards development of novel, improved oxime reactivators of OP-AChE and OP-BChE conjugates, both in vitro and in vivo.

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    Refined uncharged bis-oximes for rapid CNS reactivation of OP-inhibited hAChE.
    NIH/NINDS 1R21NS120839-01A1Apr 1, 2022 - Mar 31, 2024
    Role: PI
    Description: The principal aim of this study is to optimize structure and create improved analogues of novel “smart” uncharged bis-oxime antidotes against OP poisoning.
    In Vivo Efficacy of Novel Uncharged Bis-Oximes in OP Poisoning Treatment
    NIH/NINDS 1R21NS120884-01A1Apr 1, 2022 - Mar 31, 2024
    Role: PI
    Description: The principal aim of this study is to evaluate in vivo efficacy of novel “smart” uncharged bis-oxime antidotes against OP poisoning.
    Uncharged non-oximes for reactivation of OP-inhibited hAChE in CNS.
    University of California Academic Senate, San Diego Division RG103477Dec 1, 2021 - Nov 30, 2022
    Role: PI
    Description: The major goal of this project is to design, synthesize and perform initial characterization in vitro of enhanced uncharged non-oxime and bis-oxime reactivators of OP-conjugated human AChE.
    Novel uncharged bis-oxime antidotes to treat OP intoxication
    University of California Academic Senate, San Diego Division BG084144Jun 1, 2019 - May 31, 2021
    Role: PI
    Description: Our key objective is to develop uncharged antidote more effective than cationic ones currently in use, with higher affinity for OP-hAChE conjugates and better solubility in water. To that effect and based on our own x-ray structural information we designed and synthesized a small directed library of seven uncharged bis-oxime antidotes.
    Overlay independent X-ray data analysis for enhanced oxime OP-ChE reactivation
    NIH R21NS098998Sep 30, 2016 - Aug 31, 2019
    Role: Principal Investigator
    Accelerated AChE Reactivator Design by Mechanistic Neutron Scattering Studies
    NIH U01NS083451Jul 15, 2014 - Jun 30, 2020
    Role: Principal Investigator
    BChE reactivators for nerve agent and pesticide OP detoxification in human tissue
    NIH R21NS084904Sep 30, 2013 - Aug 31, 2016
    Role: Principal Investigator
    Optimization of nonpyridinium oximes for BChE hydrolysis of OPs in plasma
    NIH R21NS072086Sep 30, 2010 - Aug 31, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shifts in Backbone Conformation of Acetylcholinesterases upon Binding of Covalent Inhibitors, Reversible Ligands and Substrates. Crystals. 2021; 11(12):1557. Zoran Radic. . View Publication.
    2. Backbone Conformation Shifts in X-ray Structures of Human Acetylcholinesterase upon Covalent Organophosphate Inhibition. Crystals. 2021; 11(11):1270. Stephanie Luedtke; Celine Bojo; Yunshen Li; Emilio Luna; Bianca Pomar; Zoran Radic. . View Publication.
    3. Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures. J Pharmacol Exp Ther. 2021 09; 378(3):315-321. Shyong YJ, Sepulveda Y, Garcia A, Samskey NM, Radic Z, Sit RK, Sharpless KB, Momper JD, Taylor P. PMID: 34145064.
      View in: PubMed   Mentions: 1     Fields:    
    4. Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. J Biol Chem. 2020 03 27; 295(13):4079-4092. Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z. PMID: 32019865; PMCID: PMC7105318.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure. J Pharmacol Exp Ther. 2018 11; 367(2):363-372. Sit RK, Kovarik Z, Macek Hrvat N, Žunec S, Green C, Fokin VV, Sharpless KB, Radic Z, Taylor P. PMID: 30190337; PMCID: PMC6223194.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    6. Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity. Arch Toxicol. 2018 Mar; 92(3):1161-1176. Hagstrom D, Zhang S, Ho A, Tsai ES, Radic Z, Jahromi A, Kaj KJ, He Y, Taylor P, Collins ES. PMID: 29167930; PMCID: PMC6413736.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Arch Toxicol. 2017 Aug; 91(8):2837-2847. Hagstrom D, Hirokawa H, Zhang L, Radic Z, Taylor P, Collins ES. PMID: 27990564; PMCID: PMC6485937.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10749-54. Kaczanowska K, Harel M, Radic Z, Changeux JP, Finn MG, Taylor P. PMID: 25006260; PMCID: PMC4115551.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes. Biochem J. 2013 Feb 15; 450(1):231-42. Radic Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Duggan BM, Ajami D, Rebek J, Taylor P. PMID: 23216060; PMCID: PMC4772673.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    10. Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates. Chem Biol Interact. 2013 Mar 25; 203(1):67-71. Radic Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P. PMID: 22975155; PMCID: PMC3561488.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    11. Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. J Biol Chem. 2012 Apr 06; 287(15):11798-809. Radic Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Fokin VV, Sharpless KB, Taylor P. PMID: 22343626; PMCID: PMC3320928.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    12. Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. J Biol Chem. 2011 Aug 26; 286(34):29718-24. Cochran R, Kalisiak J, Küçükkilinç T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P. PMID: 21730071; PMCID: PMC3191013.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    13. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther. 2011 Jul; 338(1):125-33. Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih PA, Rao F, O'Connor DT, Taylor P. PMID: 21493754; PMCID: PMC3126649.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    14. Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase. Chem Biol Interact. 2010 Sep 06; 187(1-3):163-6. Radic Z, Kalisiak J, Fokin VV, Sharpless KB, Taylor P. PMID: 20412789; PMCID: PMC2912944.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation. Chem Biol Interact. 2010 Sep 06; 187(1-3):238-40. Küçükkilinç T, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radic Z, Taylor P. PMID: 20382137; PMCID: PMC2933076.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7606-11. Talley TT, Harel M, Hibbs RE, Radic Z, Tomizawa M, Casida JE, Taylor P. PMID: 18477694; PMCID: PMC2396707.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    17. Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chem Biol Interact. 2008 Sep 25; 175(1-3):161-5. Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. PMID: 18555981; PMCID: PMC2585062.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Acetylcholinesterase: mechanisms of covalent inhibition of H447I mutant determined by computational analyses. Chem Biol Interact. 2008 Sep 25; 175(1-3):196-9. Cheng YH, Cheng XL, Radic Z, McCammon JA. PMID: 18657802; PMCID: PMC2576475.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. The cholinesterases: analysis by pharmacogenomics in man. Chem Biol Interact. 2008 Sep 25; 175(1-3):343-5. Valle AM, Radic Z, Rana BK, Whitfield JB, O'Connor DT, Martin NG, Taylor P. PMID: 18541229; PMCID: PMC2585411.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectors. Arh Hig Rada Toksikol. 2007 Sep; 58(3):339-45. Taylor P, Reiner E, Kovarik Z, Radic Z. PMID: 17913689.
      View in: PubMed   Mentions: 4     Fields:    
    21. Acetylcholinesterase: mechanisms of covalent inhibition of wild-type and H447I mutant determined by computational analyses. J Am Chem Soc. 2007 May 23; 129(20):6562-70. Cheng Y, Cheng X, Radic Z, McCammon JA. PMID: 17461584.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    22. Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models. Biophys Chem. 2007 May; 127(3):129-39. Cheng Y, Suen JK, Radic Z, Bond SD, Holst MJ, McCammon JA. PMID: 17307283; PMCID: PMC2040065.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    23. Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure. Toxicology. 2007 Apr 20; 233(1-3):70-8. Taylor P, Kovarik Z, Reiner E, Radic Z. PMID: 17196318; PMCID: PMC3279330.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein. J Biol Chem. 2006 Dec 22; 281(51):39708-18. Hibbs RE, Radic Z, Taylor P, Johnson DA. PMID: 17068341.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    25. Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates. Toxicology. 2007 Apr 20; 233(1-3):79-84. Kovarik Z, Radic Z, Berman HA, Taylor P. PMID: 17046138.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    26. Conformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesterase. Biophys J. 2006 May 01; 90(9):3280-7. Bui JM, Radic Z, Taylor P, McCammon JA. PMID: 16473897; PMCID: PMC1432132.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family. J Biol Chem. 2006 Apr 07; 281(14):9667-76. De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor P. PMID: 16434405.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    28. Acetylcholinesterase mutants: oxime-assisted catalytic scavengers of organophosphonates. Chem Biol Interact. 2005 Dec 15; 157-158:388-90. Kovarik Z, Radic Z, Simeon-Rudolf V, Reiner E, Taylor P. PMID: 16429526.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    29. Molecular basis of interactions of cholinesterases with tight binding inhibitors. Chem Biol Interact. 2005 Dec 15; 157-158:133-41. Radic Z, Manetsch R, Krasinski A, Raushel J, Yamauchi J, Garcia C, Kolb H, Sharpless KB, Taylor P. PMID: 16289416.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Tetrameric mouse acetylcholinesterase: continuum diffusion rate calculations by solving the steady-state Smoluchowski equation using finite element methods. Biophys J. 2005 Mar; 88(3):1659-65. Zhang D, Suen J, Zhang Y, Song Y, Radic Z, Taylor P, Holst MJ, Bajaj C, Baker NA, McCammon JA. PMID: 15626705; PMCID: PMC1305222.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    31. Contemporary paradigms for cholinergic ligand design guided by biological structure. Bioorg Med Chem Lett. 2004 Apr 19; 14(8):1875-7. Taylor P, Hansen SB, Talley TT, Hibbs RE, Radic Z. PMID: 15050619; PMCID: PMC3191913.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    32. Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica. J Biol Chem. 2004 Jun 04; 279(23):24197-202. Hansen SB, Talley TT, Radic Z, Taylor P. PMID: 15069068; PMCID: PMC4762456.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    33. Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates. Biochemistry. 2004 Mar 23; 43(11):3222-9. Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. PMID: 15023072.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    34. Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates. Biochem J. 2003 Jul 01; 373(Pt 1):33-40. Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. PMID: 12665427; PMCID: PMC1223469.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    35. Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates. J Appl Toxicol. 2001 Dec; 21 Suppl 1:S13-4. Radic Z, Taylor P. PMID: 11920914.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    36. Reversibly bound and covalently attached ligands induce conformational changes in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase. J Biol Chem. 2001 Nov 09; 276(45):42196-204. Shi J, Boyd AE, Radic Z, Taylor P. PMID: 11517229.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    37. Interaction kinetics of reversible inhibitors and substrates with acetylcholinesterase and its fasciculin 2 complex. J Biol Chem. 2001 Feb 16; 276(7):4622-33. Radic Z, Taylor P. PMID: 11036076.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis. Biochemistry. 2000 May 16; 39(19):5750-7. Wong L, Radic Z, Brüggemann RJ, Hosea N, Berman HA, Taylor P. PMID: 10801325.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    39. Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity. Chem Biol Interact. 1999 May 14; 119-120:3-15. Taylor P, Wong L, Radic Z, Tsigelny I, Brüggemann R, Hosea NA, Berman HA. PMID: 10421434.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    40. The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases. Chem Biol Interact. 1999 May 14; 119-120:111-7. Radic Z, Taylor P. PMID: 10421444.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    41. Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge. Biopolymers. 1998 Dec; 46(7):465-74. Tara S, Elcock AH, Kirchhoff PD, Briggs JM, Radic Z, Taylor P, McCammon JA. PMID: 9838872.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    42. Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin. J Biol Chem. 1997 Sep 12; 272(37):23265-77. Radic Z, Kirchhoff PD, Quinn DM, McCammon JA, Taylor P. PMID: 9287336.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    43. Expression and activity of mutants of fasciculin, a peptidic acetylcholinesterase inhibitor from mamba venom. J Biol Chem. 1997 Feb 07; 272(6):3502-10. Marchot P, Prowse CN, Kanter J, Camp S, Ackermann EJ, Radic Z, Bougis PE, Taylor P. PMID: 9013597.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    44. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer. 1997; 2(3-4):249-60. Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. PMID: 9676269.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    45. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry. 1996 Aug 20; 35(33):10995-1004. Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. PMID: 8718893.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    46. Structural bases for the specificity of cholinesterase catalysis and inhibition. Toxicol Lett. 1995 Dec; 82-83:453-8. Taylor P, Radic Z, Hosea NA, Camp S, Marchot P, Berman HA. PMID: 8597093.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    47. Allosteric control of acetylcholinesterase catalysis by fasciculin. J Biol Chem. 1995 Sep 01; 270(35):20391-9. Radic Z, Quinn DM, Vellom DC, Camp S, Taylor P. PMID: 7657613.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    48. Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase. Protein Sci. 1995 Apr; 4(4):703-15. van den Born HK, Radic Z, Marchot P, Taylor P, Tsigelny I. PMID: 7613468; PMCID: PMC2143104.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    49. Expression and ligand specificity of acetylcholinesterase and the nicotinic receptor: a tale of two cholinergic sites. Biochem Soc Trans. 1994 Aug; 22(3):740-5. Taylor P, Radic Z, Kreienkamp HJ, Maeda R, Luo Z, Fuentes ME, Vellom D, Pickering N. PMID: 7821676.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    50. Site of fasciculin interaction with acetylcholinesterase. J Biol Chem. 1994 Apr 15; 269(15):11233-9. Radic Z, Duran R, Vellom DC, Li Y, Cervenansky C, Taylor P. PMID: 8157652.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    51. The cholinesterases: from genes to proteins. Annu Rev Pharmacol Toxicol. 1994; 34:281-320. Taylor P, Radic Z. PMID: 8042853.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    52. Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors. Biochemistry. 1993 Nov 16; 32(45):12074-84. Radic Z, Pickering NA, Vellom DC, Camp S, Taylor P. PMID: 8218285.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    53. Structure and regulation of expression of the acetylcholinesterase gene. Chem Biol Interact. 1993 Jun; 87(1-3):199-207. Taylor P, Li Y, Camp S, Rachinsky TL, Ekström T, Getman D, Fuentes ME, Vellom DC, Radic Z. PMID: 8343976.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    54. Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity. Biochemistry. 1993 Jan 12; 32(1):12-7. Vellom DC, Radic Z, Li Y, Pickering NA, Camp S, Taylor P. PMID: 8418833.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    55. Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants. Biochemistry. 1992 Oct 13; 31(40):9760-7. Radic Z, Gibney G, Kawamoto S, MacPhee-Quigley K, Bongiorno C, Taylor P. PMID: 1356436.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    56. Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives. Mol Pharmacol. 1991 Jan; 39(1):98-104. Radic Z, Reiner E, Taylor P. PMID: 1987454.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    57. Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action. Mol Pharmacol. 1989 Sep; 36(3):349-54. Abramson SN, Radic Z, Manker D, Faulkner DJ, Taylor P. PMID: 2779521.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
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