Peter Novick

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
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    Collapse Overview 
    Collapse Overview
    Our lab is studying the molecular mechanism of membrane traffic, particularly as it relates to cell polarity. We also study the structure and inheritance of the endoplasmic reticulum.

    Research Focus Areas:

  • Cell Division and Cell Cycle Control

  • Genetics and Genomics

  • Membrane Trafficking

  • Signal Transduction

  • Collapse Research 
    Collapse Research Activities and Funding
    Coordination of membrane traffic through rab GEF and GAP cascades
    NIH/NIGMS R01GM082861Jul 1, 2008 - Jun 30, 2021
    Role: Principal Investigator
    Structure and Inheritance of the endoplasmic reticulum
    NIH/NIGMS R01GM073892Jan 1, 2006 - Dec 31, 2010
    Role: Principal Investigator
    Molecular Membrane Biology Gordon Conference
    NIH/NCI R13CA093209Aug 5, 2001 - Jul 31, 2002
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    Membrane Traffic in Normal and Transformed Cells
    NIH/NCI P01CA046128May 1, 1988 - Dec 31, 2007
    Role: Principal Investigator
    Genetics of secretion in yeast
    NIH/NIGMS R01GM035370Jul 1, 1985 - Dec 31, 2019
    Role: Principal Investigator
    Genetics of Secretion in Yeast
    NIH/NIGMS R37GM035370Jul 1, 1985 - Dec 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chen S, Cui Y, Parashar S, Novick PJ, Ferro-Novick S. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6237-E6244. PMID: 29915089.
      View in: PubMed
    2. Liu D, Li X, Shen D, Novick P. Two subunits of the exocyst, Sec3p and Exo70p, can function exclusively on the plasma membrane. Mol Biol Cell. 2018 03 15; 29(6):736-750. PMID: 29343551.
      View in: PubMed
    3. Yuan H, Davis S, Ferro-Novick S, Novick P. Rewiring a Rab regulatory network reveals a possible inhibitory role for the vesicle tether, Uso1. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8637-E8645. PMID: 28973856.
      View in: PubMed
    4. Novick P. Regulation of membrane traffic by Rab GEF and GAP cascades. Small GTPases. 2016 10; 7(4):252-256. PMID: 27427966.
      View in: PubMed
    5. Stalder D, Novick PJ. The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. Mol Biol Cell. 2016 Feb 15; 27(4):686-701. PMID: 26700316; PMCID: PMC4750927.
    6. Casey AK, Chen S, Novick P, Ferro-Novick S, Wente SR. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Mol Biol Cell. 2015 Aug 01; 26(15):2833-44. PMID: 26041935; PMCID: PMC4571342.
    7. Stalder D, Novick PJ. Assaying the interaction of the Rab guanine nucleotide exchange protein Sec2 with the upstream Rab, a downstream effector, and a phosphoinositide. Methods Mol Biol. 2015; 1298:85-98. PMID: 25800834.
      View in: PubMed
    8. Chen S, Desai T, McNew JA, Gerard P, Novick PJ, Ferro-Novick S. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):418-23. PMID: 25548161; PMCID: PMC4299238.
    9. Sánchez-León E, Bowman B, Seidel C, Fischer R, Novick P, Riquelme M. The Rab GTPase YPT-1 associates with Golgi cisternae and Spitzenkörper microvesicles in Neurospora crassa. Mol Microbiol. 2015 Feb; 95(3):472-90. PMID: 25425138.
      View in: PubMed
    10. Liu D, Novick P. Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. J Cell Biol. 2014 Oct 13; 207(1):59-72. PMID: 25313406; PMCID: PMC4195821.
    11. Ling Y, Hayano S, Novick P. Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature. Mol Biol Cell. 2014 Nov 01; 25(21):3389-400. PMID: 25165144; PMCID: PMC4214785.
    12. Novick PJ. A pathway of a hundred genes starts with a single mutant: isolation of sec1-1. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9019-20. PMID: 24958859; PMCID: PMC4078845.
    13. Riquelme M, Bredeweg EL, Callejas-Negrete O, Roberson RW, Ludwig S, Beltrán-Aguilar A, Seiler S, Novick P, Freitag M. The Neurospora crassa exocyst complex tethers Spitzenkörper vesicles to the apical plasma membrane during polarized growth. Mol Biol Cell. 2014 Apr; 25(8):1312-26. PMID: 24523289; PMCID: PMC3982996.
    14. Stalder D, Mizuno-Yamasaki E, Ghassemian M, Novick PJ. Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):19995-20002. PMID: 24248333; PMCID: PMC3864272.
    15. Li X, Ferro-Novick S, Novick P. Different polarisome components play distinct roles in Slt2p-regulated cortical ER inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2013 Oct; 24(19):3145-54. PMID: 23924898; PMCID: PMC3784387.
    16. Shen D, Yuan H, Hutagalung A, Verma A, Kümmel D, Wu X, Reinisch K, McNew JA, Novick P. The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p. J Cell Biol. 2013 Aug 05; 202(3):509-26. PMID: 23897890; PMCID: PMC3734085.
    17. Chen S, Novick P, Ferro-Novick S. ER structure and function. Curr Opin Cell Biol. 2013 Aug; 25(4):428-33. PMID: 23478217.
      View in: PubMed
    18. Chen S, Novick P, Ferro-Novick S. ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. Nat Cell Biol. 2012 Jun 24; 14(7):707-16. PMID: 22729086; PMCID: PMC3389217.
    19. Mizuno-Yamasaki E, Rivera-Molina F, Novick P. GTPase networks in membrane traffic. Annu Rev Biochem. 2012; 81:637-59. PMID: 22463690; PMCID: PMC3708692.
    20. Hutagalung AH, Novick PJ. Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev. 2011 Jan; 91(1):119-49. PMID: 21248164; PMCID: PMC3710122.
    21. Vasan N, Hutagalung A, Novick P, Reinisch KM. Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14176-81. PMID: 20660722.
      View in: PubMed
    22. Pfeffer SR, Novick PJ. Membrane traffic. Curr Opin Cell Biol. 2010 Aug; 22(4):419-21. PMID: 20566276.
      View in: PubMed
    23. Mizuno-Yamasaki E, Medkova M, Coleman J, Novick P. Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. Dev Cell. 2010 May 18; 18(5):828-40. PMID: 20493815; PMCID: PMC2877039.
    24. Li X, Du Y, Siegel S, Ferro-Novick S, Novick P. Activation of the mitogen-activated protein kinase, Slt2p, at bud tips blocks a late stage of endoplasmic reticulum inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2010 May 15; 21(10):1772-82. PMID: 20357006.
      View in: PubMed
    25. Sclafani A, Chen S, Rivera-Molina F, Reinisch K, Novick P, Ferro-Novick S. Establishing a role for the GTPase Ypt1p at the late Golgi. Traffic. 2010 Apr; 11(4):520-32. PMID: 20059749; PMCID: PMC2861988.
    26. Rivera-Molina FE, Novick PJ. A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14408-13. PMID: 19666511; PMCID: PMC2732877.
    27. Williams DC, Novick PJ. Analysis of SEC9 suppression reveals a relationship of SNARE function to cell physiology. PLoS One. 2009; 4(5):e5449. PMID: 19421331; PMCID: PMC2674220.
    28. Hutagalung AH, Coleman J, Pypaert M, Novick PJ. An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components. Mol Biol Cell. 2009 Jan; 20(1):153-63. PMID: 18946089.
      View in: PubMed
    29. Chang W, Zaarour RF, Reck-Peterson S, Rinn J, Singer RH, Snyder M, Novick P, Mooseker MS. Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body. RNA. 2008 Mar; 14(3):491-502. PMID: 18218704; PMCID: PMC2248268.
    30. Grosshans BL, Novick P. Identification and verification of Sro7p as an effector of the Sec4p Rab GTPase. Methods Enzymol. 2008; 438:95-108. PMID: 18413243.
      View in: PubMed
    31. Dong G, Medkova M, Novick P, Reinisch KM. A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p. Mol Cell. 2007 Feb 09; 25(3):455-62. PMID: 17289591.
      View in: PubMed
    32. Du Y, Walker L, Novick P, Ferro-Novick S. Ptc1p regulates cortical ER inheritance via Slt2p. EMBO J. 2006 Oct 04; 25(19):4413-22. PMID: 16977319; PMCID: PMC1589985.
    33. Grosshans BL, Ortiz D, Novick P. Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):11821-7. PMID: 16882731; PMCID: PMC1567661.
    34. De Craene JO, Coleman J, Estrada de Martin P, Pypaert M, Anderson S, Yates JR, Ferro-Novick S, Novick P. Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell. 2006 Jul; 17(7):3009-20. PMID: 16624861.
      View in: PubMed
    35. Medkova M, France YE, Coleman J, Novick P. The rab exchange factor Sec2p reversibly associates with the exocyst. Mol Biol Cell. 2006 Jun; 17(6):2757-69. PMID: 16611746.
      View in: PubMed
    36. France YE, Boyd C, Coleman J, Novick PJ. The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit. J Cell Sci. 2006 Mar 01; 119(Pt 5):876-88. PMID: 16478783.
      View in: PubMed
    37. Grosshans BL, Andreeva A, Gangar A, Niessen S, Yates JR, Brennwald P, Novick P. The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p. J Cell Biol. 2006 Jan 02; 172(1):55-66. PMID: 16390997; PMCID: PMC2063532.
    38. Estrada de Martin P, Novick P, Ferro-Novick S. The organization, structure, and inheritance of the ER in higher and lower eukaryotes. Biochem Cell Biol. 2005 Dec; 83(6):752-61. PMID: 16333327.
      View in: PubMed
    39. Ortiz D, Novick PJ. Ypt32p regulates the translocation of Chs3p from an internal pool to the plasma membrane. Eur J Cell Biol. 2006 Feb; 85(2):107-16. PMID: 16303210.
      View in: PubMed
    40. Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM. The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. Nat Struct Mol Biol. 2005 Dec; 12(12):1094-100. PMID: 16249794.
      View in: PubMed
    41. Estrada de Martin P, Du Y, Novick P, Ferro-Novick S. Ice2p is important for the distribution and structure of the cortical ER network in Saccharomyces cerevisiae. J Cell Sci. 2005 Jan 01; 118(Pt 1):65-77. PMID: 15585575.
      View in: PubMed
    42. Wiederkehr A, De Craene JO, Ferro-Novick S, Novick P. Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. J Cell Biol. 2004 Dec 06; 167(5):875-87. PMID: 15583030; PMCID: PMC2172455.
    43. Boyd C, Hughes T, Pypaert M, Novick P. Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p. J Cell Biol. 2004 Dec 06; 167(5):889-901. PMID: 15583031; PMCID: PMC2172445.
    44. Du Y, Ferro-Novick S, Novick P. Dynamics and inheritance of the endoplasmic reticulum. J Cell Sci. 2004 Jun 15; 117(Pt 14):2871-8. PMID: 15197242.
      View in: PubMed
    45. Guo W, Novick P. The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis? Trends Cell Biol. 2004 Feb; 14(2):61-3. PMID: 15106610.
      View in: PubMed
    46. Schekman R, Novick P. 23 genes, 23 years later. Cell. 2004 Jan 23; 116(2 Suppl):S13-5, 1 p following S19. PMID: 15055575.
      View in: PubMed
    47. Estrada P, Kim J, Coleman J, Walker L, Dunn B, Takizawa P, Novick P, Ferro-Novick S. Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae. J Cell Biol. 2003 Dec 22; 163(6):1255-66. PMID: 14691136; PMCID: PMC2173705.
    48. Barrowman J, Novick P. Three Yips for Rab recruitment. Nat Cell Biol. 2003 Nov; 5(11):955-6. PMID: 14593419.
      View in: PubMed
    49. Wiederkehr A, Du Y, Pypaert M, Ferro-Novick S, Novick P. Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum. Mol Biol Cell. 2003 Dec; 14(12):4770-82. PMID: 12960429.
      View in: PubMed
    50. Ortiz D, Medkova M, Walch-Solimena C, Novick P. Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. J Cell Biol. 2002 Jun 10; 157(6):1005-15. PMID: 12045183; PMCID: PMC2174052.
    51. Novick P, Guo W. Ras family therapy: Rab, Rho and Ral talk to the exocyst. Trends Cell Biol. 2002 Jun; 12(6):247-9. PMID: 12074877.
      View in: PubMed
    52. Du LL, Novick P. Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae. Mol Biol Cell. 2002 Feb; 13(2):503-14. PMID: 11854408; PMCID: PMC65645.