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    Peter Novick

    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0644
    CA La Jolla 92093
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      Collapse Overview 
      Collapse Overview
      Our lab is studying the molecular mechanism of membrane traffic, particularly as it relates to cell polarity. We also study the structure and inheritance of the endoplasmic reticulum.

      Research Focus Areas:

    • Cell Division and Cell Cycle Control

    • Genetics and Genomics

    • Membrane Trafficking

    • Signal Transduction

    • Collapse Research 
      Collapse Research Activities and Funding
      Coordination of membrane traffic through rab GEF and GAP cascades
      NIH/NIGMS R01GM082861Jul 1, 2008 - Jun 30, 2021
      Role: Principal Investigator
      Structure and Inheritance of the endoplasmic reticulum
      NIH/NIGMS R01GM073892Jan 1, 2006 - Dec 31, 2010
      Role: Principal Investigator
      Molecular Membrane Biology Gordon Conference
      NIH/NCI R13CA093209Aug 5, 2001 - Jul 31, 2002
      Role: Principal Investigator
      Comprehensive Biology: Exploiting the Yeast Genome
      NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
      Role: Co-Investigator
      Membrane Traffic in Normal and Transformed Cells
      NIH/NCI P01CA046128May 1, 1988 - Dec 31, 2007
      Role: Principal Investigator
      Genetics of secretion in yeast
      NIH/NIGMS R01GM035370Jul 1, 1985 - Dec 31, 2019
      Role: Principal Investigator
      Genetics of Secretion in Yeast
      NIH/NIGMS R37GM035370Jul 1, 1985 - Dec 31, 2011
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Novick P. Regulation of membrane traffic by Rab GEF and GAP cascades. Small GTPases. 2016 Oct; 7(4):252-256. PMID: 27427966.
        View in: PubMed
      2. Stalder D, Novick P. The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. Mol Biol Cell. 2016 Feb 15; 27(4):686-701. PMID: 26700316; PMCID: PMC4750927.
      3. Casey AK, Chen S, Novick P, Ferro-Novick S, Wente SR. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Mol Biol Cell. 2015 Aug 01; 26(15):2833-44. PMID: 26041935; PMCID: PMC4571342.
      4. Stalder D, Novick P. Assaying the interaction of the Rab guanine nucleotide exchange protein Sec2 with the upstream Rab, a downstream effector, and a phosphoinositide. Methods Mol Biol. 2015; 1298:85-98. PMID: 25800834.
        View in: PubMed
      5. Chen S, Desai T, McNew JA, Gerard P, Novick P, Ferro-Novick S. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):418-23. PMID: 25548161; PMCID: PMC4299238.
      6. Sánchez-León E, Bowman B, Seidel C, Fischer R, Novick P, Riquelme M. The Rab GTPase YPT-1 associates with Golgi cisternae and Spitzenkörper microvesicles in Neurospora crassa. Mol Microbiol. 2015 Feb; 95(3):472-90. PMID: 25425138.
        View in: PubMed
      7. Liu D, Novick P. Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. J Cell Biol. 2014 Oct 13; 207(1):59-72. PMID: 25313406; PMCID: PMC4195821.
      8. Ling Y, Hayano S, Novick P. Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature. Mol Biol Cell. 2014 Nov 01; 25(21):3389-400. PMID: 25165144; PMCID: PMC4214785.
      9. Novick P. A pathway of a hundred genes starts with a single mutant: isolation of sec1-1. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9019-20. PMID: 24958859; PMCID: PMC4078845.
      10. Riquelme M, Bredeweg EL, Callejas-Negrete O, Roberson RW, Ludwig S, Beltrán-Aguilar A, Seiler S, Novick P, Freitag M. The Neurospora crassa exocyst complex tethers Spitzenkörper vesicles to the apical plasma membrane during polarized growth. Mol Biol Cell. 2014 Apr; 25(8):1312-26. PMID: 24523289; PMCID: PMC3982996.
      11. Stalder D, Mizuno-Yamasaki E, Ghassemian M, Novick P. Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):19995-20002. PMID: 24248333; PMCID: PMC3864272.
      12. Li X, Ferro-Novick S, Novick P. Different polarisome components play distinct roles in Slt2p-regulated cortical ER inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2013 Oct; 24(19):3145-54. PMID: 23924898; PMCID: PMC3784387.
      13. Shen D, Yuan H, Hutagalung A, Verma A, Kümmel D, Wu X, Reinisch K, McNew JA, Novick P. The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p. J Cell Biol. 2013 Aug 05; 202(3):509-26. PMID: 23897890; PMCID: PMC3734085.
      14. Chen S, Novick P, Ferro-Novick S. ER structure and function. Curr Opin Cell Biol. 2013 Aug; 25(4):428-33. PMID: 23478217.
        View in: PubMed
      15. Chen S, Novick P, Ferro-Novick S. ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. Nat Cell Biol. 2012 Jun 24; 14(7):707-16. PMID: 22729086; PMCID: PMC3389217.
      16. Mizuno-Yamasaki E, Rivera-Molina F, Novick P. GTPase networks in membrane traffic. Annu Rev Biochem. 2012; 81:637-59. PMID: 22463690; PMCID: PMC3708692.
      17. Hutagalung AH, Novick P. Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev. 2011 Jan; 91(1):119-49. PMID: 21248164; PMCID: PMC3710122.
      18. Vasan N, Hutagalung A, Novick P, Reinisch KM. Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14176-81. PMID: 20660722; PMCID: PMC2922553.
      19. Pfeffer SR, Novick P. Membrane traffic. Curr Opin Cell Biol. 2010 Aug; 22(4):419-21. PMID: 20566276.
        View in: PubMed
      20. Mizuno-Yamasaki E, Medkova M, Coleman J, Novick P. Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. Dev Cell. 2010 May 18; 18(5):828-40. PMID: 20493815; PMCID: PMC2877039.
      21. Li X, Du Y, Siegel S, Ferro-Novick S, Novick P. Activation of the mitogen-activated protein kinase, Slt2p, at bud tips blocks a late stage of endoplasmic reticulum inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2010 May 15; 21(10):1772-82. PMID: 20357006; PMCID: PMC2869382.
      22. Sclafani A, Chen S, Rivera-Molina F, Reinisch K, Novick P, Ferro-Novick S. Establishing a role for the GTPase Ypt1p at the late Golgi. Traffic. 2010 Apr; 11(4):520-32. PMID: 20059749; PMCID: PMC2861988.
      23. Rivera-Molina FE, Novick P. A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14408-13. PMID: 19666511; PMCID: PMC2732877.
      24. Williams DC, Novick P. Analysis of SEC9 suppression reveals a relationship of SNARE function to cell physiology. PLoS One. 2009; 4(5):e5449. PMID: 19421331; PMCID: PMC2674220.
      25. Hutagalung AH, Coleman J, Pypaert M, Novick P. An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components. Mol Biol Cell. 2009 Jan; 20(1):153-63. PMID: 18946089; PMCID: PMC2613103.
      26. Chang W, Zaarour RF, Reck-Peterson S, Rinn J, Singer RH, Snyder M, Novick P, Mooseker MS. Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body. RNA. 2008 Mar; 14(3):491-502. PMID: 18218704; PMCID: PMC2248268.
      27. Grosshans BL, Novick P. Identification and verification of Sro7p as an effector of the Sec4p Rab GTPase. Methods Enzymol. 2008; 438:95-108. PMID: 18413243.
        View in: PubMed
      28. Dong G, Medkova M, Novick P, Reinisch KM. A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p. Mol Cell. 2007 Feb 09; 25(3):455-62. PMID: 17289591; PMCID: PMC1847580.
      29. Novick P, Medkova M, Dong G, Hutagalung A, Reinisch K, Grosshans B. Interactions between Rabs, tethers, SNAREs and their regulators in exocytosis. Biochem Soc Trans. 2006 Nov; 34(Pt 5):683-6. PMID: 17052174.
        View in: PubMed
      30. Du Y, Walker L, Novick P, Ferro-Novick S. Ptc1p regulates cortical ER inheritance via Slt2p. EMBO J. 2006 Oct 04; 25(19):4413-22. PMID: 16977319; PMCID: PMC1589985.
      31. Grosshans BL, Ortiz D, Novick P. Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):11821-7. PMID: 16882731; PMCID: PMC1567661.
      32. De Craene JO, Coleman J, Estrada de Martin P, Pypaert M, Anderson S, Yates JR, Ferro-Novick S, Novick P. Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell. 2006 Jul; 17(7):3009-20. PMID: 16624861; PMCID: PMC1483037.
      33. Medkova M, France YE, Coleman J, Novick P. The rab exchange factor Sec2p reversibly associates with the exocyst. Mol Biol Cell. 2006 Jun; 17(6):2757-69. PMID: 16611746; PMCID: PMC1474791.
      34. France YE, Boyd C, Coleman J, Novick P. The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit. J Cell Sci. 2006 Mar 01; 119(Pt 5):876-88. PMID: 16478783.
        View in: PubMed
      35. Grosshans BL, Andreeva A, Gangar A, Niessen S, Yates JR, Brennwald P, Novick P. The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p. J Cell Biol. 2006 Jan 02; 172(1):55-66. PMID: 16390997; PMCID: PMC2063532.
      36. Estrada de Martin P, Novick P, Ferro-Novick S. The organization, structure, and inheritance of the ER in higher and lower eukaryotes. Biochem Cell Biol. 2005 Dec; 83(6):752-61. PMID: 16333327.
        View in: PubMed
      37. Ortiz D, Novick P. Ypt32p regulates the translocation of Chs3p from an internal pool to the plasma membrane. Eur J Cell Biol. 2006 Feb; 85(2):107-16. PMID: 16303210.
        View in: PubMed
      38. Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM. The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. Nat Struct Mol Biol. 2005 Dec; 12(12):1094-100. PMID: 16249794.
        View in: PubMed
      39. Estrada de Martin P, Du Y, Novick P, Ferro-Novick S. Ice2p is important for the distribution and structure of the cortical ER network in Saccharomyces cerevisiae. J Cell Sci. 2005 Jan 01; 118(Pt 1):65-77. PMID: 15585575.
        View in: PubMed
      40. Boyd C, Hughes T, Pypaert M, Novick P. Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p. J Cell Biol. 2004 Dec 06; 167(5):889-901. PMID: 15583031; PMCID: PMC2172445.
      41. Wiederkehr A, De Craene JO, Ferro-Novick S, Novick P. Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. J Cell Biol. 2004 Dec 06; 167(5):875-87. PMID: 15583030; PMCID: PMC2172455.
      42. Du Y, Ferro-Novick S, Novick P. Dynamics and inheritance of the endoplasmic reticulum. J Cell Sci. 2004 Jun 15; 117(Pt 14):2871-8. PMID: 15197242.
        View in: PubMed
      43. Guo W, Novick P. The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis? Trends Cell Biol. 2004 Feb; 14(2):61-3. PMID: 15106610.
        View in: PubMed
      44. Schekman R, Novick P. 23 genes, 23 years later. Cell. 2004 Jan 23; 116(2 Suppl):S13-5, 1 p following S19. PMID: 15055575.
        View in: PubMed
      45. Estrada P, Kim J, Coleman J, Walker L, Dunn B, Takizawa P, Novick P, Ferro-Novick S. Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae. J Cell Biol. 2003 Dec 22; 163(6):1255-66. PMID: 14691136; PMCID: PMC2173705.
      46. Barrowman J, Novick P. Three Yips for Rab recruitment. Nat Cell Biol. 2003 Nov; 5(11):955-6. PMID: 14593419.
        View in: PubMed
      47. Wiederkehr A, Du Y, Pypaert M, Ferro-Novick S, Novick P. Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum. Mol Biol Cell. 2003 Dec; 14(12):4770-82. PMID: 12960429; PMCID: PMC284782.
      48. Ortiz D, Medkova M, Walch-Solimena C, Novick P. Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. J Cell Biol. 2002 Jun 10; 157(6):1005-15. PMID: 12045183; PMCID: PMC2174052.
      49. Novick P, Guo W. Ras family therapy: Rab, Rho and Ral talk to the exocyst. Trends Cell Biol. 2002 Jun; 12(6):247-9. PMID: 12074877.
        View in: PubMed
      50. Du LL, Novick P. Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae. Mol Biol Cell. 2002 Feb; 13(2):503-14. PMID: 11854408; PMCID: PMC65645.
      51. Zhang X, Bi E, Novick P, Du L, Kozminski KG, Lipschutz JH, Guo W. Cdc42 interacts with the exocyst and regulates polarized secretion. J Biol Chem. 2001 Dec 14; 276(50):46745-50. PMID: 11595741.
        View in: PubMed
      52. Du Y, Pypaert M, Novick P, Ferro-Novick S. Aux1p/Swa2p is required for cortical endoplasmic reticulum inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2001 Sep; 12(9):2614-28. PMID: 11553703; PMCID: PMC59699.
      53. Drees BL, Sundin B, Brazeau E, Caviston JP, Chen GC, Guo W, Kozminski KG, Lau MW, Moskow JJ, Tong A, Schenkman LR, McKenzie A, Brennwald P, Longtine M, Bi E, Chan C, Novick P, Boone C, Pringle JR, Davis TN, Fields S, Drubin DG. A protein interaction map for cell polarity development. J Cell Biol. 2001 Aug 06; 154(3):549-71. PMID: 11489916; PMCID: PMC2196425.
      54. Reck-Peterson SL, Tyska MJ, Novick P, Mooseker MS. The yeast class V myosins, Myo2p and Myo4p, are nonprocessive actin-based motors. J Cell Biol. 2001 May 28; 153(5):1121-6. PMID: 11381095; PMCID: PMC2174330.
      55. Du LL, Novick P. Yeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p. Mol Biol Cell. 2001 May; 12(5):1215-26. PMID: 11359917; PMCID: PMC34579.
      56. Guo W, Tamanoi F, Novick P. Spatial regulation of the exocyst complex by Rho1 GTPase. Nat Cell Biol. 2001 Apr; 3(4):353-60. PMID: 11283608.
        View in: PubMed
      57. Terbush DR, Guo W, Dunkelbarger S, Novick P. Purification and characterization of yeast exocyst complex. Methods Enzymol. 2001; 329:100-10. PMID: 11210526.
        View in: PubMed
      58. Du LL, Novick P. Purification and properties of a GTPase-activating protein for yeast Rab GTPases. Methods Enzymol. 2001; 329:91-9. PMID: 11210577.
        View in: PubMed
      59. Grote E, Vlacich G, Pypaert M, Novick P. A snc1 endocytosis mutant: phenotypic analysis and suppression by overproduction of dihydrosphingosine phosphate lyase. Mol Biol Cell. 2000 Dec; 11(12):4051-65. PMID: 11102507; PMCID: PMC15056.
      60. Lipschutz JH, Guo W, O'Brien LE, Nguyen YH, Novick P, Mostov KE. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. Mol Biol Cell. 2000 Dec; 11(12):4259-75. PMID: 11102522; PMCID: PMC15071.
      61. Finger FP, Novick P. Synthetic interactions of the post-Golgi sec mutations of Saccharomyces cerevisiae. Genetics. 2000 Nov; 156(3):943-51. PMID: 11063675; PMCID: PMC1461333.
      62. Grote E, Carr CM, Novick P. Ordering the final events in yeast exocytosis. J Cell Biol. 2000 Oct 16; 151(2):439-52. PMID: 11038189; PMCID: PMC2192655.
      63. Grote E, Baba M, Ohsumi Y, Novick P. Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion. J Cell Biol. 2000 Oct 16; 151(2):453-66. PMID: 11038190; PMCID: PMC2192637.
      64. Guo W, Sacher M, Barrowman J, Ferro-Novick S, Novick P. Protein complexes in transport vesicle targeting. Trends Cell Biol. 2000 Jun; 10(6):251-5. PMID: 10802541.
        View in: PubMed
      65. Karpova TS, Reck-Peterson SL, Elkind NB, Mooseker MS, Novick P, Cooper JA. Role of actin and Myo2p in polarized secretion and growth of Saccharomyces cerevisiae. Mol Biol Cell. 2000 May; 11(5):1727-37. PMID: 10793147; PMCID: PMC14879.
      66. Elkind NB, Walch-Solimena C, Novick P. The role of the COOH terminus of Sec2p in the transport of post-Golgi vesicles. J Cell Biol. 2000 Apr 03; 149(1):95-110. PMID: 10747090; PMCID: PMC2175086.
      67. Carr CM, Novick P. Membrane fusion. Changing partners. Nature. 2000 Mar 23; 404(6776):347-9. PMID: 10746709.
        View in: PubMed
      68. Walch-Solimena C, Novick P. The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi. Nat Cell Biol. 1999 Dec; 1(8):523-5. PMID: 10587649.
        View in: PubMed
      69. Grote E, Novick P. Promiscuity in Rab-SNARE interactions. Mol Biol Cell. 1999 Dec; 10(12):4149-61. PMID: 10588649; PMCID: PMC25749.
      70. Guo W, Grant A, Novick P. Exo84p is an exocyst protein essential for secretion. J Biol Chem. 1999 Aug 13; 274(33):23558-64. PMID: 10438536.
        View in: PubMed
      71. Carr CM, Grote E, Munson M, Hughson FM, Novick P. Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol. 1999 Jul 26; 146(2):333-44. PMID: 10427089; PMCID: PMC3206579.
      72. Reck-Peterson SL, Novick P, Mooseker MS. The tail of a yeast class V myosin, myo2p, functions as a localization domain. Mol Biol Cell. 1999 Apr; 10(4):1001-17. PMID: 10198053; PMCID: PMC25227.
      73. Guo W, Roth D, Walch-Solimena C, Novick P. The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J. 1999 Feb 15; 18(4):1071-80. PMID: 10022848; PMCID: PMC1171198.
      74. Finger FP, Novick P. Spatial regulation of exocytosis: lessons from yeast. J Cell Biol. 1998 Aug 10; 142(3):609-12. PMID: 9700152; PMCID: PMC2148161.
      75. Roth D, Guo W, Novick P. Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast. Mol Biol Cell. 1998 Jul; 9(7):1725-39. PMID: 9658167; PMCID: PMC25411.
      76. Abeliovich H, Grote E, Novick P, Ferro-Novick S. Tlg2p, a yeast syntaxin homolog that resides on the Golgi and endocytic structures. J Biol Chem. 1998 May 08; 273(19):11719-27. PMID: 9565594.
        View in: PubMed
      77. Finger FP, Hughes TE, Novick P. Sec3p is a spatial landmark for polarized secretion in budding yeast. Cell. 1998 Feb 20; 92(4):559-71. PMID: 9491896.
        View in: PubMed
      78. Du LL, Collins RN, Novick P. Identification of a Sec4p GTPase-activating protein (GAP) as a novel member of a Rab GAP family. J Biol Chem. 1998 Feb 06; 273(6):3253-6. PMID: 9452439.
        View in: PubMed
      79. Novick P, Zerial M. The diversity of Rab proteins in vesicle transport. Curr Opin Cell Biol. 1997 Aug; 9(4):496-504. PMID: 9261061.
        View in: PubMed
      80. Collins RN, Brennwald P, Garrett M, Lauring A, Novick P. Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast. J Biol Chem. 1997 Jul 18; 272(29):18281-9. PMID: 9218467.
        View in: PubMed
      81. Walch-Solimena C, Collins RN, Novick P. Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol. 1997 Jun 30; 137(7):1495-509. PMID: 9199166; PMCID: PMC2137815.
      82. Finger FP, Novick P. Sec3p is involved in secretion and morphogenesis in Saccharomyces cerevisiae. Mol Biol Cell. 1997 Apr; 8(4):647-62. PMID: 9247645; PMCID: PMC276116.
      83. Guo W, Roth D, Gatti E, De Camilli P, Novick P. Identification and characterization of homologues of the Exocyst component Sec10p. FEBS Lett. 1997 Mar 10; 404(2-3):135-9. PMID: 9119050.
        View in: PubMed
      84. TerBush DR, Maurice T, Roth D, Novick P. The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J. 1996 Dec 02; 15(23):6483-94. PMID: 8978675; PMCID: PMC452473.
      85. De Camilli P, Emr SD, McPherson PS, Novick P. Phosphoinositides as regulators in membrane traffic. Science. 1996 Mar 15; 271(5255):1533-9. PMID: 8599109.
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      86. Govindan B, Novick P. Development of cell polarity in budding yeast. J Exp Zool. 1995 Dec 01; 273(5):401-24. PMID: 8576696.
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      87. TerBush DR, Novick P. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol. 1995 Jul; 130(2):299-312. PMID: 7615633; PMCID: PMC2199927.
      88. Govindan B, Bowser R, Novick P. The role of Myo2, a yeast class V myosin, in vesicular transport. J Cell Biol. 1995 Mar; 128(6):1055-68. PMID: 7896871; PMCID: PMC2120422.
      89. Roberts DM, Garrett MD, Novick P. Purification of GDP dissociation stimulator Dss4 from recombinant bacteria. Methods Enzymol. 1995; 257:84-92. PMID: 8583942.
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      90. Novick P, Garrett MD, Brennwald P, Lauring A, Finger FP, Collins R, TerBush DR. Control of exocytosis in yeast. Cold Spring Harb Symp Quant Biol. 1995; 60:171-7. PMID: 8824389.
        View in: PubMed
      91. Brennwald P, Kearns B, Champion K, Keränen S, Bankaitis V, Novick P. Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis. Cell. 1994 Oct 21; 79(2):245-58. PMID: 7954793.
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      92. Novick P, Garrett MD. Vesicular transport. No exchange without receipt. Nature. 1994 May 05; 369(6475):18-9. PMID: 8164732.
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      93. Garrett MD, Zahner JE, Cheney CM, Novick P. GDI1 encodes a GDP dissociation inhibitor that plays an essential role in the yeast secretory pathway. EMBO J. 1994 Apr 01; 13(7):1718-28. PMID: 8157010; PMCID: PMC395005.
      94. Novick P, Brennwald P. Friends and family: the role of the Rab GTPases in vesicular traffic. Cell. 1993 Nov 19; 75(4):597-601. PMID: 8242735.
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      95. Garrett MD, Kabcenell AK, Zahner JE, Kaibuchi K, Sasaki T, Takai Y, Cheney CM, Novick P. Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity. FEBS Lett. 1993 Oct 04; 331(3):233-8. PMID: 8375508.
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      96. Protopopov V, Govindan B, Novick P, Gerst JE. Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell. 1993 Sep 10; 74(5):855-61. PMID: 8374953.
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      97. Brennwald P, Novick P. Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4. Nature. 1993 Apr 08; 362(6420):560-3. PMID: 8464498.
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      98. Moya M, Roberts D, Novick P. DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function. Nature. 1993 Feb 04; 361(6411):460-3. PMID: 8429886.
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      99. Burton J, Roberts D, Montaldi M, Novick P, De Camilli P. A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4. Nature. 1993 Feb 04; 361(6411):464-7. PMID: 8429887.
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      100. Ferro-Novick S, Novick P. The role of GTP-binding proteins in transport along the exocytic pathway. Annu Rev Cell Biol. 1993; 9:575-99. PMID: 8280472.
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      101. Novick P, Brennwald P, Walworth NC, Kabcenell AK, Garrett M, Moya M, Roberts D, Müller H, Govindan B, Bowser R. The cycle of SEC4 function in vesicular transport. Ciba Found Symp. 1993; 176:218-28; discussion 229-32. PMID: 8299422.
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      102. Bowser R, Müller H, Govindan B, Novick P. Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis. J Cell Biol. 1992 Sep; 118(5):1041-56. PMID: 1512289; PMCID: PMC2289594.
      103. Jena BP, Brennwald P, Garrett MD, Novick P, Jamieson JD. Distinct and specific GAP activities in rat pancreas act on the yeast GTP-binding proteins Ypt1 and Sec4. FEBS Lett. 1992 Aug 31; 309(1):5-9. PMID: 1511744.
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      104. Potenza M, Bowser R, Müller H, Novick P. SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast. Yeast. 1992 Jul; 8(7):549-58. PMID: 1523887.
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      105. Walworth NC, Brennwald P, Kabcenell AK, Garrett M, Novick P. Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae. Mol Cell Biol. 1992 May; 12(5):2017-28. PMID: 1569938; PMCID: PMC364372.
      106. Novick P, Garrett MD, Brennwald P, Kabcenell AK. Purification of Sec4 protein from Saccharomyces cerevisiae and Escherichia coli. Methods Enzymol. 1992; 219:352-62. PMID: 1488008.
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      107. Sasaki T, Kaibuchi K, Kabcenell AK, Novick P, Takai Y. A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein. Mol Cell Biol. 1991 May; 11(5):2909-12. PMID: 1901952; PMCID: PMC360085.
      108. Bowser R, Novick P. Sec15 protein, an essential component of the exocytotic apparatus, is associated with the plasma membrane and with a soluble 19.5S particle. J Cell Biol. 1991 Mar; 112(6):1117-31. PMID: 1900300; PMCID: PMC2288896.
      109. Kabcenell AK, Goud B, Northup JK, Novick P. Binding and hydrolysis of guanine nucleotides by Sec4p, a yeast protein involved in the regulation of vesicular traffic. J Biol Chem. 1990 Jun 05; 265(16):9366-72. PMID: 2111819.
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      110. Nair J, Müller H, Peterson M, Novick P. Sec2 protein contains a coiled-coil domain essential for vesicular transport and a dispensable carboxy terminal domain. J Cell Biol. 1990 Jun; 110(6):1897-909. PMID: 1693620; PMCID: PMC2116119.
      111. Cleves AE, Novick P, Bankaitis VA. Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function. J Cell Biol. 1989 Dec; 109(6 Pt 1):2939-50. PMID: 2687291; PMCID: PMC2115899.
      112. Bacon RA, Salminen A, Ruohola H, Novick P, Ferro-Novick S. The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants. J Cell Biol. 1989 Sep; 109(3):1015-22. PMID: 2504726; PMCID: PMC2115776.
      113. Salminen A, Novick P. The Sec15 protein responds to the function of the GTP binding protein, Sec4, to control vesicular traffic in yeast. J Cell Biol. 1989 Sep; 109(3):1023-36. PMID: 2504727; PMCID: PMC2115742.
      114. Walworth NC, Goud B, Kabcenell AK, Novick P. Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic. EMBO J. 1989 Jun; 8(6):1685-93. PMID: 2504585; PMCID: PMC401010.
      115. Novick P, Osmond BC, Botstein D. Suppressors of yeast actin mutations. Genetics. 1989 Apr; 121(4):659-74. PMID: 2656401; PMCID: PMC1203651.
      116. Walworth NC, Goud B, Ruohola H, Novick P. Fractionation of yeast organelles. Methods Cell Biol. 1989; 31:335-56. PMID: 2674627.
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      117. Goud B, Salminen A, Walworth NC, Novick P. A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast. Cell. 1988 Jun 03; 53(5):753-68. PMID: 3131018.
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      118. Novick P, Goud B, Salminen A, Walworth NC, Nair J, Potenza M. Regulation of vesicular traffic by a GTP-binding protein on the cytoplasmic surface of secretory vesicles in yeast. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:637-47. PMID: 3151180.
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      119. Walworth NC, Novick P. Purification and characterization of constitutive secretory vesicles from yeast. J Cell Biol. 1987 Jul; 105(1):163-74. PMID: 3301865; PMCID: PMC2114885.
      120. Salminen A, Novick P. A ras-like protein is required for a post-Golgi event in yeast secretion. Cell. 1987 May 22; 49(4):527-38. PMID: 3552249.
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      121. Novick P, Botstein D. Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell. 1985 Feb; 40(2):405-16. PMID: 3967297.
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      122. Shortle D, Novick P, Botstein D. Construction and genetic characterization of temperature-sensitive mutant alleles of the yeast actin gene. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4889-93. PMID: 6379652; PMCID: PMC391597.
      123. Ferro-Novick S, Novick P, Field C, Schekman R. Yeast secretory mutants that block the formation of active cell surface enzymes. J Cell Biol. 1984 Jan; 98(1):35-43. PMID: 6368571; PMCID: PMC2113008.
      124. Novick P, Schekman R. Export of major cell surface proteins is blocked in yeast secretory mutants. J Cell Biol. 1983 Feb; 96(2):541-7. PMID: 6339519; PMCID: PMC2112282.
      125. Schekman R, Esmon B, Ferro-Novick S, Field C, Novick P. Yeast secretory mutants: isolation and characterization. Methods Enzymol. 1983; 96:802-15. PMID: 6361466.
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      126. Esmon B, Novick P, Schekman R. Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast. Cell. 1981 Aug; 25(2):451-60. PMID: 7026044.
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      127. Novick P, Schekman R. Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1858-62. PMID: 377286; PMCID: PMC383491.