Peter Novick

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    Our lab is studying the molecular mechanism of membrane traffic, particularly as it relates to cell polarity. We also study the structure and inheritance of the endoplasmic reticulum.

    Research Focus Areas:

  • Cell Division and Cell Cycle Control

  • Genetics and Genomics

  • Membrane Trafficking

  • Signal Transduction

  • Collapse Research 
    Collapse Research Activities and Funding
    Coordination of membrane traffic through rab GEF and GAP cascades
    NIH R01GM082861Jul 1, 2008 - Jun 30, 2021
    Role: Principal Investigator
    Structure and Inheritance of the endoplasmic reticulum
    NIH R01GM073892Jan 1, 2006 - Dec 31, 2010
    Role: Principal Investigator
    Molecular Membrane Biology Gordon Conference
    NIH R13CA093209Aug 5, 2001 - Jul 31, 2002
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    Genetics of secretion in yeast
    NIH R01GM035370Jul 1, 1985 - Jun 30, 2024
    Role: Principal Investigator
    Genetics of Secretion in Yeast
    NIH R37GM035370Jul 1, 1985 - Dec 31, 2011
    Role: Principal Investigator
    Membrane Traffic in Normal and Transformed Cells
    NIH P01CA046128Dec 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Exploring the consequences of redirecting an exocytic Rab onto endocytic vesicles. Mol Biol Cell. 2023 05 01; 34(5):ar38. Li X, Liu D, Griffis E, Novick P. PMID: 36857153; PMCID: PMC10162416.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Exploring the consequences of redirecting an exocytic Rab onto endocytic vesicles. bioRxiv. 2023 Feb 10. Li X, Liu D, Griffis E, Novick P. PMID: 36798320; PMCID: PMC9934678.
      View in: PubMed   Mentions:
    3. Double NPY motifs at the N-terminus of the yeast t-SNARE Sso2 synergistically bind Sec3 to promote membrane fusion. Elife. 2022 08 18; 11. Peer M, Yuan H, Zhang Y, Korbula K, Novick P, Dong G. PMID: 35979953; PMCID: PMC9427108.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Actin assembly at sites of contact between the cortical ER and endocytic pits promotes ER autophagy. Autophagy. 2023 01; 19(1):358-359. Liu D, Ferro-Novick S, Novick P. PMID: 35532158; PMCID: PMC9809928.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Autophagy of the ER requires actin assembly driven by the interaction of ER with endocytic pits. Contact (Thousand Oaks). 2022 Jan-Dec; 5. Novick P, Liu D, Ferro-Novick S. PMID: 37102157; PMCID: PMC10129067.
      View in: PubMed   Mentions:
    6. ER-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Liu D, Mari M, Li X, Reggiori F, Ferro-Novick S, Novick P. PMID: 35101986; PMCID: PMC8833162.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    7. Testing the Phenotypic Effects of a Rab Chimera that Resolves Exchange Factor Specificity from Effector Specificity. Methods Mol Biol. 2021; 2293:57-67. Yuan H, Novick P. PMID: 34453710.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Proc Natl Acad Sci U S A. 2020 08 04; 117(31):18530-18539. Chen S, Mari M, Parashar S, Liu D, Cui Y, Reggiori F, Novick PJ, Ferro-Novick S. PMID: 32690699; PMCID: PMC7414049.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    9. GIV/Girdin and Exo70 Collaboratively Regulate the Mammalian Polarized Exocytic Machinery. iScience. 2020 Jul 24; 23(7):101246. Rohena C, Rajapakse N, Lo IC, Novick P, Sahoo D, Ghosh P. PMID: 32590327; PMCID: PMC7322189.
      View in: PubMed   Mentions: 1  
    10. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6237-E6244. Chen S, Cui Y, Parashar S, Novick PJ, Ferro-Novick S. PMID: 29915089; PMCID: PMC6142256.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    11. Two subunits of the exocyst, Sec3p and Exo70p, can function exclusively on the plasma membrane. Mol Biol Cell. 2018 03 15; 29(6):736-750. Liu D, Li X, Shen D, Novick P. PMID: 29343551; PMCID: PMC6003224.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Rewiring a Rab regulatory network reveals a possible inhibitory role for the vesicle tether, Uso1. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8637-E8645. Yuan H, Davis S, Ferro-Novick S, Novick P. PMID: 28973856; PMCID: PMC5642711.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    13. Regulation of membrane traffic by Rab GEF and GAP cascades. Small GTPases. 2016 10; 7(4):252-256. Novick P. PMID: 27427966; PMCID: PMC5129893.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    14. The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. Mol Biol Cell. 2016 Feb 15; 27(4):686-701. Stalder D, Novick PJ. PMID: 26700316; PMCID: PMC4750927.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    15. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Mol Biol Cell. 2015 Aug 01; 26(15):2833-44. Casey AK, Chen S, Novick P, Ferro-Novick S, Wente SR. PMID: 26041935; PMCID: PMC4571342.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    16. Assaying the interaction of the Rab guanine nucleotide exchange protein Sec2 with the upstream Rab, a downstream effector, and a phosphoinositide. Methods Mol Biol. 2015; 1298:85-98. Stalder D, Novick PJ. PMID: 25800834.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    17. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):418-23. Chen S, Desai T, McNew JA, Gerard P, Novick PJ, Ferro-Novick S. PMID: 25548161; PMCID: PMC4299238.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    18. The Rab GTPase YPT-1 associates with Golgi cisternae and Spitzenkörper microvesicles in Neurospora crassa. Mol Microbiol. 2015 Feb; 95(3):472-90. Sánchez-León E, Bowman B, Seidel C, Fischer R, Novick P, Riquelme M. PMID: 25425138.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. J Cell Biol. 2014 Oct 13; 207(1):59-72. Liu D, Novick P. PMID: 25313406; PMCID: PMC4195821.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    20. Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature. Mol Biol Cell. 2014 Nov 01; 25(21):3389-400. Ling Y, Hayano S, Novick P. PMID: 25165144; PMCID: PMC4214785.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    21. A pathway of a hundred genes starts with a single mutant: isolation of sec1-1. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9019-20. Novick PJ. PMID: 24958859; PMCID: PMC4078845.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    22. The Neurospora crassa exocyst complex tethers Spitzenkörper vesicles to the apical plasma membrane during polarized growth. Mol Biol Cell. 2014 Apr; 25(8):1312-26. Riquelme M, Bredeweg EL, Callejas-Negrete O, Roberson RW, Ludwig S, Beltrán-Aguilar A, Seiler S, Novick P, Freitag M. PMID: 24523289; PMCID: PMC3982996.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    23. Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):19995-20002. Stalder D, Mizuno-Yamasaki E, Ghassemian M, Novick PJ. PMID: 24248333; PMCID: PMC3864272.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    24. Different polarisome components play distinct roles in Slt2p-regulated cortical ER inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2013 Oct; 24(19):3145-54. Li X, Ferro-Novick S, Novick P. PMID: 23924898; PMCID: PMC3784387.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p. J Cell Biol. 2013 Aug 05; 202(3):509-26. Shen D, Yuan H, Hutagalung A, Verma A, Kümmel D, Wu X, Reinisch K, McNew JA, Novick P. PMID: 23897890; PMCID: PMC3734085.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    26. ER structure and function. Curr Opin Cell Biol. 2013 Aug; 25(4):428-33. Chen S, Novick P, Ferro-Novick S. PMID: 23478217; PMCID: PMC5614462.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    27. ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. Nat Cell Biol. 2012 Jun 24; 14(7):707-16. Chen S, Novick P, Ferro-Novick S. PMID: 22729086; PMCID: PMC3389217.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    28. GTPase networks in membrane traffic. Annu Rev Biochem. 2012; 81:637-59. Mizuno-Yamasaki E, Rivera-Molina F, Novick P. PMID: 22463690; PMCID: PMC3708692.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    29. Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev. 2011 Jan; 91(1):119-49. Hutagalung AH, Novick PJ. PMID: 21248164; PMCID: PMC3710122.
      View in: PubMed   Mentions: 754     Fields:    Translation:HumansAnimalsCells
    30. Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14176-81. Vasan N, Hutagalung A, Novick P, Reinisch KM. PMID: 20660722; PMCID: PMC2922553.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    31. Membrane traffic. Curr Opin Cell Biol. 2010 Aug; 22(4):419-21. Pfeffer SR, Novick PJ. PMID: 20566276.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    32. Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. Dev Cell. 2010 May 18; 18(5):828-40. Mizuno-Yamasaki E, Medkova M, Coleman J, Novick P. PMID: 20493815; PMCID: PMC2877039.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    33. Activation of the mitogen-activated protein kinase, Slt2p, at bud tips blocks a late stage of endoplasmic reticulum inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2010 May 15; 21(10):1772-82. Li X, Du Y, Siegel S, Ferro-Novick S, Novick P. PMID: 20357006; PMCID: PMC2869382.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. Establishing a role for the GTPase Ypt1p at the late Golgi. Traffic. 2010 Apr; 11(4):520-32. Sclafani A, Chen S, Rivera-Molina F, Reinisch K, Novick P, Ferro-Novick S. PMID: 20059749; PMCID: PMC2861988.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    35. A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14408-13. Rivera-Molina FE, Novick PJ. PMID: 19666511; PMCID: PMC2732877.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    36. Analysis of SEC9 suppression reveals a relationship of SNARE function to cell physiology. PLoS One. 2009; 4(5):e5449. Williams DC, Novick PJ. PMID: 19421331; PMCID: PMC2674220.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components. Mol Biol Cell. 2009 Jan; 20(1):153-63. Hutagalung AH, Coleman J, Pypaert M, Novick PJ. PMID: 18946089; PMCID: PMC2613103.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    38. Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body. RNA. 2008 Mar; 14(3):491-502. Chang W, Zaarour RF, Reck-Peterson S, Rinn J, Singer RH, Snyder M, Novick P, Mooseker MS. PMID: 18218704; PMCID: PMC2248268.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Identification and verification of Sro7p as an effector of the Sec4p Rab GTPase. Methods Enzymol. 2008; 438:95-108. Grosshans BL, Novick P. PMID: 18413243.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    40. A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p. Mol Cell. 2007 Feb 09; 25(3):455-62. Dong G, Medkova M, Novick P, Reinisch KM. PMID: 17289591; PMCID: PMC1847580.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    41. Interactions between Rabs, tethers, SNAREs and their regulators in exocytosis. Biochem Soc Trans. 2006 Nov; 34(Pt 5):683-6. Novick P, Medkova M, Dong G, Hutagalung A, Reinisch K, Grosshans B. PMID: 17052174.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    42. Ptc1p regulates cortical ER inheritance via Slt2p. EMBO J. 2006 Oct 04; 25(19):4413-22. Du Y, Walker L, Novick P, Ferro-Novick S. PMID: 16977319; PMCID: PMC1589985.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    43. Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):11821-7. Grosshans BL, Ortiz D, Novick P. PMID: 16882731; PMCID: PMC1567661.
      View in: PubMed   Mentions: 521     Fields:    Translation:Cells
    44. Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell. 2006 Jul; 17(7):3009-20. De Craene JO, Coleman J, Estrada de Martin P, Pypaert M, Anderson S, Yates JR, Ferro-Novick S, Novick P. PMID: 16624861; PMCID: PMC1483037.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    45. The rab exchange factor Sec2p reversibly associates with the exocyst. Mol Biol Cell. 2006 Jun; 17(6):2757-69. Medkova M, France YE, Coleman J, Novick P. PMID: 16611746; PMCID: PMC1474791.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    46. The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit. J Cell Sci. 2006 Mar 01; 119(Pt 5):876-88. France YE, Boyd C, Coleman J, Novick PJ. PMID: 16478783.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    47. The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p. J Cell Biol. 2006 Jan 02; 172(1):55-66. Grosshans BL, Andreeva A, Gangar A, Niessen S, Yates JR, Brennwald P, Novick P. PMID: 16390997; PMCID: PMC2063532.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    48. The organization, structure, and inheritance of the ER in higher and lower eukaryotes. Biochem Cell Biol. 2005 Dec; 83(6):752-61. Estrada de Martin P, Novick P, Ferro-Novick S. PMID: 16333327.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    49. Ypt32p regulates the translocation of Chs3p from an internal pool to the plasma membrane. Eur J Cell Biol. 2006 Feb; 85(2):107-16. Ortiz D, Novick PJ. PMID: 16303210.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    50. The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. Nat Struct Mol Biol. 2005 Dec; 12(12):1094-100. Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM. PMID: 16249794.
      View in: PubMed   Mentions: 81     Fields:    Translation:Cells
    51. Ice2p is important for the distribution and structure of the cortical ER network in Saccharomyces cerevisiae. J Cell Sci. 2005 Jan 01; 118(Pt 1):65-77. Estrada de Martin P, Du Y, Novick P, Ferro-Novick S. PMID: 15585575.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    52. Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. J Cell Biol. 2004 Dec 06; 167(5):875-87. Wiederkehr A, De Craene JO, Ferro-Novick S, Novick P. PMID: 15583030; PMCID: PMC2172455.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    53. Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p. J Cell Biol. 2004 Dec 06; 167(5):889-901. Boyd C, Hughes T, Pypaert M, Novick P. PMID: 15583031; PMCID: PMC2172445.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    54. Dynamics and inheritance of the endoplasmic reticulum. J Cell Sci. 2004 Jun 15; 117(Pt 14):2871-8. Du Y, Ferro-Novick S, Novick P. PMID: 15197242.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    55. The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis? Trends Cell Biol. 2004 Feb; 14(2):61-3. Guo W, Novick P. PMID: 15106610.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    56. 23 genes, 23 years later. Cell. 2004 Jan 23; 116(2 Suppl):S13-5, 1 p following S19. Schekman R, Novick P. PMID: 15055575.
      View in: PubMed   Mentions: 33     Fields:    
    57. Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae. J Cell Biol. 2003 Dec 22; 163(6):1255-66. Estrada P, Kim J, Coleman J, Walker L, Dunn B, Takizawa P, Novick P, Ferro-Novick S. PMID: 14691136; PMCID: PMC2173705.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    58. Three Yips for Rab recruitment. Nat Cell Biol. 2003 Nov; 5(11):955-6. Barrowman J, Novick P. PMID: 14593419.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    59. Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum. Mol Biol Cell. 2003 Dec; 14(12):4770-82. Wiederkehr A, Du Y, Pypaert M, Ferro-Novick S, Novick P. PMID: 12960429; PMCID: PMC284782.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    60. Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae. Mol Biol Cell. 2002 Feb; 13(2):503-14. Du LL, Novick P. PMID: 11854408; PMCID: PMC65645.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    61. Aux1p/Swa2p is required for cortical endoplasmic reticulum inheritance in Saccharomyces cerevisiae. Mol Biol Cell. 2001 Sep; 12(9):2614-28. Du Y, Pypaert M, Novick P, Ferro-Novick S. PMID: 11553703; PMCID: PMC59699.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    62. The yeast class V myosins, Myo2p and Myo4p, are nonprocessive actin-based motors. J Cell Biol. 2001 May 28; 153(5):1121-6. Reck-Peterson SL, Tyska MJ, Novick PJ, Mooseker MS. PMID: 11381095; PMCID: PMC2174330.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    63. Yeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p. Mol Biol Cell. 2001 May; 12(5):1215-26. Du LL, Novick P. PMID: 11359917; PMCID: PMC34579.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    64. Spatial regulation of the exocyst complex by Rho1 GTPase. Nat Cell Biol. 2001 Apr; 3(4):353-60. Guo W, Tamanoi F, Novick P. PMID: 11283608.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    65. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. Mol Biol Cell. 2000 Dec; 11(12):4259-75. Lipschutz JH, Guo W, O'Brien LE, Nguyen YH, Novick P, Mostov KE. PMID: 11102522; PMCID: PMC15071.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    66. A snc1 endocytosis mutant: phenotypic analysis and suppression by overproduction of dihydrosphingosine phosphate lyase. Mol Biol Cell. 2000 Dec; 11(12):4051-65. Grote E, Vlacich G, Pypaert M, Novick PJ. PMID: 11102507; PMCID: PMC15056.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    67. Synthetic interactions of the post-Golgi sec mutations of Saccharomyces cerevisiae. Genetics. 2000 Nov; 156(3):943-51. Finger FP, Novick P. PMID: 11063675; PMCID: PMC1461333.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    68. Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion. J Cell Biol. 2000 Oct 16; 151(2):453-66. Grote E, Baba M, Ohsumi Y, Novick PJ. PMID: 11038190; PMCID: PMC2192637.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    69. Ordering the final events in yeast exocytosis. J Cell Biol. 2000 Oct 16; 151(2):439-52. Grote E, Carr CM, Novick PJ. PMID: 11038189; PMCID: PMC2192655.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    70. Protein complexes in transport vesicle targeting. Trends Cell Biol. 2000 Jun; 10(6):251-5. Guo W, Sacher M, Barrowman J, Ferro-Novick S, Novick P. PMID: 10802541.
      View in: PubMed   Mentions: 77     Fields:    Translation:Cells
    71. Role of actin and Myo2p in polarized secretion and growth of Saccharomyces cerevisiae. Mol Biol Cell. 2000 May; 11(5):1727-37. Karpova TS, Reck-Peterson SL, Elkind NB, Mooseker MS, Novick PJ, Cooper JA. PMID: 10793147; PMCID: PMC14879.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    72. The role of the COOH terminus of Sec2p in the transport of post-Golgi vesicles. J Cell Biol. 2000 Apr 03; 149(1):95-110. Elkind NB, Walch-Solimena C, Novick PJ. PMID: 10747090; PMCID: PMC2175086.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    73. Membrane fusion. Changing partners. Nature. 2000 Mar 23; 404(6776):347-9. Carr CM, Novick PJ. PMID: 10746709.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    74. The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi. Nat Cell Biol. 1999 Dec; 1(8):523-5. Walch-Solimena C, Novick P. PMID: 10587649.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    75. Promiscuity in Rab-SNARE interactions. Mol Biol Cell. 1999 Dec; 10(12):4149-61. Grote E, Novick PJ. PMID: 10588649; PMCID: PMC25749.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    76. Exo84p is an exocyst protein essential for secretion. J Biol Chem. 1999 Aug 13; 274(33):23558-64. Guo W, Grant A, Novick P. PMID: 10438536.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    77. Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol. 1999 Jul 26; 146(2):333-44. Carr CM, Grote E, Munson M, Hughson FM, Novick PJ. PMID: 10427089; PMCID: PMC3206579.
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    78. The tail of a yeast class V myosin, myo2p, functions as a localization domain. Mol Biol Cell. 1999 Apr; 10(4):1001-17. Reck-Peterson SL, Novick PJ, Mooseker MS. PMID: 10198053; PMCID: PMC25227.
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    79. The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J. 1999 Feb 15; 18(4):1071-80. Guo W, Roth D, Walch-Solimena C, Novick P. PMID: 10022848; PMCID: PMC1171198.
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    80. Spatial regulation of exocytosis: lessons from yeast. J Cell Biol. 1998 Aug 10; 142(3):609-12. Finger FP, Novick P. PMID: 9700152; PMCID: PMC2148161.
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    81. Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast. Mol Biol Cell. 1998 Jul; 9(7):1725-39. Roth D, Guo W, Novick P. PMID: 9658167; PMCID: PMC25411.
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    82. Tlg2p, a yeast syntaxin homolog that resides on the Golgi and endocytic structures. J Biol Chem. 1998 May 08; 273(19):11719-27. Abeliovich H, Grote E, Novick P, Ferro-Novick S. PMID: 9565594.
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    83. Sec3p is a spatial landmark for polarized secretion in budding yeast. Cell. 1998 Feb 20; 92(4):559-71. Finger FP, Hughes TE, Novick P. PMID: 9491896.
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    84. Identification of a Sec4p GTPase-activating protein (GAP) as a novel member of a Rab GAP family. J Biol Chem. 1998 Feb 06; 273(6):3253-6. Du LL, Collins RN, Novick PJ. PMID: 9452439.
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    85. The diversity of Rab proteins in vesicle transport. Curr Opin Cell Biol. 1997 Aug; 9(4):496-504. Novick P, Zerial M. PMID: 9261061.
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    86. Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast. J Biol Chem. 1997 Jul 18; 272(29):18281-9. Collins RN, Brennwald P, Garrett M, Lauring A, Novick P. PMID: 9218467.
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    87. Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol. 1997 Jun 30; 137(7):1495-509. Walch-Solimena C, Collins RN, Novick PJ. PMID: 9199166; PMCID: PMC2137815.
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    88. Sec3p is involved in secretion and morphogenesis in Saccharomyces cerevisiae. Mol Biol Cell. 1997 Apr; 8(4):647-62. Finger FP, Novick P. PMID: 9247645; PMCID: PMC276116.
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    89. Identification and characterization of homologues of the Exocyst component Sec10p. FEBS Lett. 1997 Mar 10; 404(2-3):135-9. Guo W, Roth D, Gatti E, De Camilli P, Novick P. PMID: 9119050.
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    90. The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J. 1996 Dec 02; 15(23):6483-94. TerBush DR, Maurice T, Roth D, Novick P. PMID: 8978675; PMCID: PMC452473.
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    91. Phosphoinositides as regulators in membrane traffic. Science. 1996 Mar 15; 271(5255):1533-9. De Camilli P, Emr SD, McPherson PS, Novick P. PMID: 8599109.
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    92. Development of cell polarity in budding yeast. J Exp Zool. 1995 Dec 01; 273(5):401-24. Govindan B, Novick P. PMID: 8576696.
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    93. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol. 1995 Jul; 130(2):299-312. TerBush DR, Novick P. PMID: 7615633; PMCID: PMC2199927.
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    94. The role of Myo2, a yeast class V myosin, in vesicular transport. J Cell Biol. 1995 Mar; 128(6):1055-68. Govindan B, Bowser R, Novick P. PMID: 7896871; PMCID: PMC2120422.
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    95. Control of exocytosis in yeast. Cold Spring Harb Symp Quant Biol. 1995; 60:171-7. Novick P, Garrett MD, Brennwald P, Lauring A, Finger FP, Collins R, TerBush DR. PMID: 8824389.
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    96. Purification of GDP dissociation stimulator Dss4 from recombinant bacteria. Methods Enzymol. 1995; 257:84-92. Roberts DM, Garrett MD, Novick PJ. PMID: 8583942.
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    97. Expression, purification, and assays of Gdi1p from recombinant Escherichia coli. Methods Enzymol. 1995; 257:232-40. Garrett MD, Novick PJ. PMID: 8583926.
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    98. Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis. Cell. 1994 Oct 21; 79(2):245-58. Brennwald P, Kearns B, Champion K, Keränen S, Bankaitis V, Novick P. PMID: 7954793.
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    99. Vesicular transport. No exchange without receipt. Nature. 1994 May 05; 369(6475):18-9. Novick P, Garrett MD. PMID: 8164732.
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    100. GDI1 encodes a GDP dissociation inhibitor that plays an essential role in the yeast secretory pathway. EMBO J. 1994 Apr 01; 13(7):1718-28. Garrett MD, Zahner JE, Cheney CM, Novick PJ. PMID: 8157010; PMCID: PMC395005.
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    101. Friends and family: the role of the Rab GTPases in vesicular traffic. Cell. 1993 Nov 19; 75(4):597-601. Novick P, Brennwald P. PMID: 8242735.
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    102. Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity. FEBS Lett. 1993 Oct 04; 331(3):233-8. Garrett MD, Kabcenell AK, Zahner JE, Kaibuchi K, Sasaki T, Takai Y, Cheney CM, Novick PJ. PMID: 8375508.
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    103. Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell. 1993 Sep 10; 74(5):855-61. Protopopov V, Govindan B, Novick P, Gerst JE. PMID: 8374953.
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    104. Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4. Nature. 1993 Apr 08; 362(6420):560-3. Brennwald P, Novick P. PMID: 8464498.
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    105. A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4. Nature. 1993 Feb 04; 361(6411):464-7. Burton J, Roberts D, Montaldi M, Novick P, De Camilli P. PMID: 8429887.
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    106. DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function. Nature. 1993 Feb 04; 361(6411):460-3. Moya M, Roberts D, Novick P. PMID: 8429886.
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    107. The role of GTP-binding proteins in transport along the exocytic pathway. Annu Rev Cell Biol. 1993; 9:575-99. Ferro-Novick S, Novick P. PMID: 8280472.
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    108. The cycle of SEC4 function in vesicular transport. Ciba Found Symp. 1993; 176:218-28; discussion 229-32. Novick P, Brennwald P, Walworth NC, Kabcenell AK, Garrett M, Moya M, Roberts D, Müller H, Govindan B, Bowser R. PMID: 8299422.
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    109. Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis. J Cell Biol. 1992 Sep; 118(5):1041-56. Bowser R, Müller H, Govindan B, Novick P. PMID: 1512289; PMCID: PMC2289594.
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    110. Distinct and specific GAP activities in rat pancreas act on the yeast GTP-binding proteins Ypt1 and Sec4. FEBS Lett. 1992 Aug 31; 309(1):5-9. Jena BP, Brennwald P, Garrett MD, Novick P, Jamieson JD. PMID: 1511744.
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    111. SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast. Yeast. 1992 Jul; 8(7):549-58. Potenza M, Bowser R, Müller H, Novick P. PMID: 1523887.
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    112. Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae. Mol Cell Biol. 1992 May; 12(5):2017-28. Walworth NC, Brennwald P, Kabcenell AK, Garrett M, Novick P. PMID: 1569938; PMCID: PMC364372.
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    113. Purification of Sec4 protein from Saccharomyces cerevisiae and Escherichia coli. Methods Enzymol. 1992; 219:352-62. Novick P, Garrett MD, Brennwald P, Kabcenell AK. PMID: 1488008.
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    114. A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein. Mol Cell Biol. 1991 May; 11(5):2909-12. Sasaki T, Kaibuchi K, Kabcenell AK, Novick PJ, Takai Y. PMID: 1901952; PMCID: PMC360085.
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    115. Sec15 protein, an essential component of the exocytotic apparatus, is associated with the plasma membrane and with a soluble 19.5S particle. J Cell Biol. 1991 Mar; 112(6):1117-31. Bowser R, Novick P. PMID: 1900300; PMCID: PMC2288896.
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    116. Binding and hydrolysis of guanine nucleotides by Sec4p, a yeast protein involved in the regulation of vesicular traffic. J Biol Chem. 1990 Jun 05; 265(16):9366-72. Kabcenell AK, Goud B, Northup JK, Novick PJ. PMID: 2111819.
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    117. Sec2 protein contains a coiled-coil domain essential for vesicular transport and a dispensable carboxy terminal domain. J Cell Biol. 1990 Jun; 110(6):1897-909. Nair J, Müller H, Peterson M, Novick P. PMID: 1693620; PMCID: PMC2116119.
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    118. Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function. J Cell Biol. 1989 Dec; 109(6 Pt 1):2939-50. Cleves AE, Novick PJ, Bankaitis VA. PMID: 2687291; PMCID: PMC2115899.
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    119. The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants. J Cell Biol. 1989 Sep; 109(3):1015-22. Bacon RA, Salminen A, Ruohola H, Novick P, Ferro-Novick S. PMID: 2504726; PMCID: PMC2115776.
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    120. The Sec15 protein responds to the function of the GTP binding protein, Sec4, to control vesicular traffic in yeast. J Cell Biol. 1989 Sep; 109(3):1023-36. Salminen A, Novick PJ. PMID: 2504727; PMCID: PMC2115742.
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    121. Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic. EMBO J. 1989 Jun; 8(6):1685-93. Walworth NC, Goud B, Kabcenell AK, Novick PJ. PMID: 2504585; PMCID: PMC401010.
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    122. Suppressors of yeast actin mutations. Genetics. 1989 Apr; 121(4):659-74. Novick P, Osmond BC, Botstein D. PMID: 2656401; PMCID: PMC1203651.
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    123. Fractionation of yeast organelles. Methods Cell Biol. 1989; 31:335-56. Walworth NC, Goud B, Ruohola H, Novick PJ. PMID: 2674627.
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    124. A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast. Cell. 1988 Jun 03; 53(5):753-68. Goud B, Salminen A, Walworth NC, Novick PJ. PMID: 3131018.
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    125. Regulation of vesicular traffic by a GTP-binding protein on the cytoplasmic surface of secretory vesicles in yeast. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:637-47. Novick PJ, Goud B, Salminen A, Walworth NC, Nair J, Potenza M. PMID: 3151180.
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    126. Purification and characterization of constitutive secretory vesicles from yeast. J Cell Biol. 1987 Jul; 105(1):163-74. Walworth NC, Novick PJ. PMID: 3301865; PMCID: PMC2114885.
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    127. A ras-like protein is required for a post-Golgi event in yeast secretion. Cell. 1987 May 22; 49(4):527-38. Salminen A, Novick PJ. PMID: 3552249.
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    128. Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell. 1985 Feb; 40(2):405-16. Novick P, Botstein D. PMID: 3967297.
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    129. Construction and genetic characterization of temperature-sensitive mutant alleles of the yeast actin gene. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4889-93. Shortle D, Novick P, Botstein D. PMID: 6379652; PMCID: PMC391597.
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    130. Yeast secretory mutants that block the formation of active cell surface enzymes. J Cell Biol. 1984 Jan; 98(1):35-43. Ferro-Novick S, Novick P, Field C, Schekman R. PMID: 6368571; PMCID: PMC2113008.
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    131. Export of major cell surface proteins is blocked in yeast secretory mutants. J Cell Biol. 1983 Feb; 96(2):541-7. Novick P, Schekman R. PMID: 6339519; PMCID: PMC2112282.
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    132. Yeast secretory mutants: isolation and characterization. Methods Enzymol. 1983; 96:802-15. Schekman R, Esmon B, Ferro-Novick S, Field C, Novick P. PMID: 6361466.
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    133. Order of events in the yeast secretory pathway. Cell. 1981 Aug; 25(2):461-9. Novick P, Ferro S, Schekman R. PMID: 7026045.
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    134. Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast. Cell. 1981 Aug; 25(2):451-60. Esmon B, Novick P, Schekman R. PMID: 7026044.
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    135. Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1858-62. Novick P, Schekman R. PMID: 377286; PMCID: PMC383491.
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