Darren Casteel

Title(s)Project Scientist, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Study of mTOR Regulation by Rheb Using Deuterium Exchange Mass Spectrometry
    NIH K22CA124517Sep 17, 2007 - Aug 31, 2011
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A plasma membrane-associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells. Sci Signal. 2024 Jan 30; 17(821):eadi7861. Kalyanaraman H, Casteel DE, China SP, Zhuang S, Boss GR, Pilz RB. PMID: 38289986; PMCID: PMC10916501.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome. JACC Basic Transl Sci. 2024 Jan; 9(1):46-62. Kalyanaraman H, Casteel DE, Cabriales JA, Tat J, Zhuang S, Chan A, Dretchen KL, Boss GR, Pilz RB. PMID: 38362350; PMCID: PMC10864892.
      View in: PubMed   Mentions:
    3. Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3. J Biol Chem. 2023 04; 299(4):104584. Hu T, Kalyanaraman H, Pilz RB, Casteel DE. PMID: 36889588; PMCID: PMC10124902.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice. J Bone Miner Res. 2023 01; 38(1):171-185. Kalyanaraman H, Pal China S, Cabriales JA, Moininazeri J, Casteel DE, Garcia JJ, Wong VW, Chen A, Sah RL, Boss GR, Pilz RB. PMID: 36371651; PMCID: PMC9825661.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice. PNAS Nexus. 2022 Sep; 1(4):pgac191. Chang S, Tat J, China SP, Kalyanaraman H, Zhuang S, Chan A, Lai C, Radic Z, Abdel-Rahman EA, Casteel DE, Pilz RB, Ali SS, Boss GR. PMID: 36276587; PMCID: PMC9578022.
      View in: PubMed   Mentions: 2  
    6. An auto-inhibited state of protein kinase G and implications for selective activation. Elife. 2022 08 05; 11. Sharma R, Kim JJ, Qin L, Henning P, Akimoto M, VanSchouwen B, Kaur G, Sankaran B, MacKenzie KR, Melacini G, Casteel DE, Herberg FW, Kim C. PMID: 35929723; PMCID: PMC9417419.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells. J Biol Chem. 2022 08; 298(8):102175. Aminzai S, Hu T, Pilz RB, Casteel DE. PMID: 35752367; PMCID: PMC9293632.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Bladder Cancer Invasion Is Mediated by Mammalian Target of Rapamycin Complex 2-Driven Regulation of Nitric Oxide and Invadopodia Formation. Am J Pathol. 2021 12; 191(12):2203-2218. Sahu D, Huan J, Wang H, Sahoo D, Casteel DE, Klemke RL, Boss GR, Hansel DE. PMID: 34428425.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. Br J Pharmacol. 2022 06; 179(11):2413-2429. Schwaerzer GK, Casteel DE, Cividini F, Kalyanaraman H, Zhuang S, Gu Y, Dalton ND, Peterson KL, Dillmann WH, Boss GR, Pilz RB. PMID: 34000062; PMCID: PMC9926932.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function. Diabetes. 2021 03; 70(3):665-679. Cividini F, Scott BT, Suarez J, Casteel DE, Heinz S, Dai A, Diemer T, Suarez JA, Benner CW, Ghassemian M, Dillmann WH. PMID: 33303689; PMCID: PMC7897348.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity. Sci Rep. 2020 11 16; 10(1):19907. Wahwah N, Dhar D, Chen H, Zhuang S, Chan A, Casteel DE, Kalyanaraman H, Pilz RB, Boss GR. PMID: 33199755; PMCID: PMC7670436.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. J Biol Chem. 2020 07 24; 295(30):10394-10405. Chan MH, Aminzai S, Hu T, Taran A, Li S, Kim C, Pilz RB, Casteel DE. PMID: 32506052; PMCID: PMC7383375.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly. J Transl Med. 2020 Jan 16; 18(1):27. Kim C, Sharma R, Casteel DE. PMID: 31948450; PMCID: PMC6966794.
      View in: PubMed   Mentions: 1     Fields:    
    14. Letter by Casteel Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of the cGMP-Dependent Protein Kinase". Circulation. 2019 11 26; 140(22):e808-e809. Casteel DE. PMID: 31765253.
      View in: PubMed   Mentions:    Fields:    
    15. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun. 2019 08 06; 10(1):3533. Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. PMID: 31387997; PMCID: PMC6684604.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    16. cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss. J Endocrinol. 2018 09; 238(3):203-219. Ramdani G, Schall N, Kalyanaraman H, Wahwah N, Moheize S, Lee JJ, Sah RL, Pfeifer A, Casteel DE, Pilz RB. PMID: 29914933; PMCID: PMC6086127.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46. J Biol Chem. 2018 07 13; 293(28):10985-10992. Qin L, Sankaran B, Aminzai S, Casteel DE, Kim C. PMID: 29769318; PMCID: PMC6052212.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem. 2018 03 23; 293(12):4411-4421. Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS. PMID: 29378851; PMCID: PMC5868259.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes. Diabetes. 2018 04; 67(4):607-623. Kalyanaraman H, Schwaerzer G, Ramdani G, Castillo F, Scott BT, Dillmann W, Sah RL, Casteel DE, Pilz RB. PMID: 29301852; PMCID: PMC5860855.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    20. The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43. J Biol Chem. 2017 05 19; 292(20):8262-8268. Kalyanaraman H, Zhuang S, Pilz RB, Casteel DE. PMID: 28360102; PMCID: PMC5437233.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    21. Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase. Am J Pathol. 2017 01; 187(1):200-213. Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel DE, Boss GR, Hansel DE. PMID: 27979310; PMCID: PMC5225295.
      View in: PubMed   Mentions: 12     Fields:    
    22. AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2. Mol Cell Biol. 2016 12 15; 36(24):3086-3099. Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF. PMID: 27697864; PMCID: PMC5126295.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    23. O-GlcNAcylation of 8-Oxoguanine DNA Glycosylase (Ogg1) Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts. J Biol Chem. 2016 Dec 16; 291(51):26515-26528. Cividini F, Scott BT, Dai A, Han W, Suarez J, Diaz-Juarez J, Diemer T, Casteel DE, Dillmann WH. PMID: 27816939; PMCID: PMC5159511.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    24. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017 01; 32(1):46-59. Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB. PMID: 27391172; PMCID: PMC5199609.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    25. Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure. 2016 05 03; 24(5):710-720. Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim C. PMID: 27066748; PMCID: PMC4856591.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    26. Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J Biol Chem. 2016 Mar 11; 291(11):5623-5633. Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C. PMID: 26769964; PMCID: PMC4786703.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. Structures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability. Biochemistry. 2015 Jul 28; 54(29):4419-22. Qin L, Reger AS, Guo E, Yang MP, Zwart P, Casteel DE, Kim C. PMID: 26132214; PMCID: PMC4838416.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions. J Biol Chem. 2014 Sep 12; 289(37):25393-403. Reger AS, Yang MP, Koide-Yoshida S, Guo E, Mehta S, Yuasa K, Liu A, Casteel DE, Kim C. PMID: 25070890; PMCID: PMC4162144.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    29. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Sci Signal. 2014 May 20; 7(326):ra48. Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB. PMID: 24847117; PMCID: PMC6504257.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    30. Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I. Structure. 2014 Jan 07; 22(1):116-24. Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C. PMID: 24239458; PMCID: PMC4019043.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    31. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. Biochem J. 2013 Aug 15; 454(1):91-9. Fridman A, Saha A, Chan A, Casteel DE, Pilz RB, Boss GR. PMID: 23734909.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    32. Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet. 2013 Aug 08; 93(2):398-404. Guo DC, Regalado E, Casteel DE, Santos-Cortez RL, Gong L, Kim JJ, Dyack S, Horne SG, Chang G, Jondeau G, Boileau C, Coselli JS, Li Z, Leal SM, Shendure J, Rieder MJ, Bamshad MJ, Nickerson DA, GenTAC Registry Consortium, National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project, Kim C, Milewicz DM. PMID: 23910461; PMCID: PMC3738837.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    33. cGMP-dependent protein kinase Iβ regulates breast cancer cell migration and invasion via interaction with the actin/myosin-associated protein caldesmon. J Cell Sci. 2013 Apr 01; 126(Pt 7):1626-36. Schwappacher R, Rangaswami H, Su-Yuo J, Hassad A, Spitler R, Casteel DE. PMID: 23418348; PMCID: PMC3647439.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    34. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012 Nov 02; 287(45):38367-78. Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB. PMID: 22992742; PMCID: PMC3488105.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    35. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 2011; 79 Suppl 10:6-20. Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T. PMID: 22020785; PMCID: PMC3692002.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    36. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor SS, Dostmann WR. PMID: 21893290; PMCID: PMC3168983.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    37. The amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein's cGMP-binding pockets. Int J Mass Spectrom. 2011 Apr 30; 302(1-3):44-52. Lee JH, Li S, Liu T, Hsu S, Kim C, Woods VL, Casteel DE. PMID: 21643460; PMCID: PMC3107041.
      View in: PubMed   Mentions: 7  
    38. Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413. Kim JJ, Casteel DE, Huang G, Kwon TH, Ren RK, Zwart P, Headd JJ, Brown NG, Chow DC, Palzkill T, Kim C. PMID: 21526164; PMCID: PMC3080414.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    39. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. PMID: 21177494; PMCID: PMC3093297.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    40. A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring. J Biol Chem. 2010 Oct 22; 285(43):32684-32688. Casteel DE, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C. PMID: 20826808; PMCID: PMC2963381.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    41. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem. 2009 Feb 27; 284(9):5807-18. Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. PMID: 19119139; PMCID: PMC2645831.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    42. cGMP-dependent protein kinase anchoring by IRAG regulates its nuclear translocation and transcriptional activity. Cell Signal. 2008 Jul; 20(7):1392-9. Casteel DE, Zhang T, Zhuang S, Pilz RB. PMID: 18450420; PMCID: PMC2477739.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    43. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. J Biol Chem. 2007 Nov 16; 282(46):33367-33380. Zhang T, Zhuang S, Casteel DE, Looney DJ, Boss GR, Pilz RB. PMID: 17878170.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    44. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. J Biol Chem. 2005 Nov 18; 280(46):38211-8. Casteel DE, Boss GR, Pilz RB. PMID: 16166082.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    45. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem. 2005 Mar 18; 280(11):10073-82. Kambo A, Sharma VS, Casteel DE, Woods VL, Pilz RB, Boss GR. PMID: 15647267.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. Regulation of gene expression by cyclic GMP. Circ Res. 2003 Nov 28; 93(11):1034-46. Pilz RB, Casteel DE. PMID: 14645134.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    47. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol Cell Biol. 2003 Jun; 23(12):4066-82. Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB. PMID: 12773552; PMCID: PMC156132.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    48. cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions. J Biol Chem. 2002 Oct 04; 277(40):37382-93. Gudi T, Chen JC, Casteel DE, Seasholtz TM, Boss GR, Pilz RB. PMID: 12119292.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    49. cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I. J Biol Chem. 2002 Aug 30; 277(35):32003-14. Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB. PMID: 12082086.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
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