Julijus Bogomolovas

Title(s)	Assistant Project Scientist, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Understanding the molecular basis of cardiomyopathy. Am J Physiol Heart Circ Physiol. 2022 02 01; 322(2):H181-H233. Bang ML, Bogomolovas J, Chen J. PMID: 34797172; PMCID: PMC8759964.

View in: PubMed Mentions: 10 Fields:
Car Cardiology Phy Physiology
Translation:Humans Animals Cells
Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021 06 01; 131(11). Liang Y, Lyon RC, Pellman J, Bradford WH, Lange S, Bogomolovas J, Dalton ND, Gu Y, Bobar M, Lee MH, Iwakuma T, Nigam V, Asimaki A, Scheinman M, Peterson KL, Sheikh F. PMID: 33857019; PMCID: PMC8159691.

View in: PubMed Mentions: 10 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 04 13; 14(678). Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. PMID: 33850054; PMCID: PMC8208635.

View in: PubMed Mentions: 31 Fields:
Cel Cell Biology Phy Physiology Sci Science
Translation:Animals Cells
Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism. J Mol Biol. 2021 04 30; 433(9):166901. Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O. PMID: 33647290; PMCID: PMC8052292.

View in: PubMed Mentions: 14 Fields:
Mol Molecular Biology
Translation:Animals Cells
Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1. Int J Mol Sci. 2021 Feb 23; 22(4). Labeit S, Hirner S, Bogomolovas J, Cruz A, Myrzabekova M, Moriscot A, Bowen TS, Adams V. PMID: 33672385; PMCID: PMC7926706.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals Cells
Atypical ALPK2 kinase is not essential for cardiac development and function. Am J Physiol Heart Circ Physiol. 2020 06 01; 318(6):H1509-H1515. Bogomolovas J, Feng W, Yu MD, Huang S, Zhang L, Trexler C, Gu Y, Spinozzi S, Chen J. PMID: 32383995; PMCID: PMC7311700.

View in: PubMed Mentions: 3 Fields:
Car Cardiology Phy Physiology
Translation:Animals Cells
Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease. Sci Transl Med. 2020 03 18; 12(535). Manso AM, Hashem SI, Nelson BC, Gault E, Soto-Hermida A, Villarruel E, Brambatti M, Bogomolovas J, Bushway PJ, Chen C, Battiprolu P, Keravala A, Schwartz JD, Shah G, Gu Y, Dalton ND, Hammond K, Peterson K, Saftig P, Adler ED. PMID: 32188720.

View in: PubMed Mentions: 25 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals
The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy. Medicina (Kaunas). 2020 Jan 09; 56(1). Baltruniene V, Rinkunaite I, Bogomolovas J, Bironaite D, Kažukauskiene I, Šimoliunas E, Rucinskas K, Puronaite R, Bukelskiene V, Grabauskiene AV. PMID: 31936691; PMCID: PMC7023024.

View in: PubMed Mentions: 4 Fields:
Med Medicine (General)
Translation:Humans
Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal. Adv Mater. 2019 Apr; 31(17):e1807521. Hill CJ, Fleming JR, Mousavinejad M, Nicholson R, Tzokov SB, Bullough PA, Bogomolovas J, Morgan MR, Mayans O, Murray P. PMID: 30866118.

View in: PubMed Mentions: 3 Fields:
Bio Biophysics Che Chemistry
Translation:Humans Cells
The BAG3-dependent and -independent roles of cardiac small heat shock proteins. JCI Insight. 2019 02 21; 4(4). Fang X, Bogomolovas J, Trexler C, Chen J. PMID: 30830872; PMCID: PMC6478417.

View in: PubMed Mentions: 12 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
PKC and PKN in heart disease. J Mol Cell Cardiol. 2019 03; 128:212-226. Marrocco V, Bogomolovas J, Ehler E, Dos Remedios CG, Yu J, Gao C, Lange S. PMID: 30742812; PMCID: PMC6408329.

View in: PubMed Mentions: 26 Fields:
Car Cardiology Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
P209L mutation in Bag3 does not cause cardiomyopathy in mice. Am J Physiol Heart Circ Physiol. 2019 02 01; 316(2):H392-H399. Fang X, Bogomolovas J, Zhou PS, Mu Y, Ma X, Chen Z, Zhang L, Zhu M, Veevers J, Ouyang K, Chen J. PMID: 30499714; PMCID: PMC6397380.

View in: PubMed Mentions: 12 Fields:
Car Cardiology Phy Physiology
Translation:Animals Cells
Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. Circ Res. 2018 08 03; 123(4):428-442. Boogerd CJ, Zhu X, Aneas I, Sakabe N, Zhang L, Sobreira DR, Montefiori L, Bogomolovas J, Joslin AC, Zhou B, Chen J, Nobrega MA, Evans SM. PMID: 29903739; PMCID: PMC6092109.

View in: PubMed Mentions: 27 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Animals Cells
Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages. Circ Res. 2018 02 16; 122(4):583-590. Moore-Morris T, Cattaneo P, Guimarães-Camboa N, Bogomolovas J, Cedenilla M, Banerjee I, Ricote M, Kisseleva T, Zhang L, Gu Y, Dalton ND, Peterson KL, Chen J, Pucéat M, Evans SM. PMID: 29269349; PMCID: PMC5815911.

View in: PubMed Mentions: 38 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Animals Cells
The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure. Biomed Res Int. 2017; 2017:3818292. Baltruniene V, Bironaite D, Kažukauskiene I, Bogomolovas J, Vitkus D, Rucinskas K, Žurauskas E, Augulis R, Grabauskiene V. PMID: 29318144; PMCID: PMC5727561.

View in: PubMed Mentions: 8 Fields:
Bio Biotechnology Med Medicine (General)
Translation:Humans CTClinical Trials
HSPB7 is indispensable for heart development by modulating actin filament assembly. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):11956-11961. Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J. PMID: 29078393; PMCID: PMC5692592.

View in: PubMed Mentions: 33 Fields:
Sci Science
Translation:Animals Cells
Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01; 127(8):3189-3200. Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. PMID: 28737513; PMCID: PMC5531406.

View in: PubMed Mentions: 75 Fields:
Med Medicine (General)
Translation:Animals Cells
A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19. Biomed Res Int. 2016; 2016:1627184. Bogomolovas J, Šimoliunas E, Rinkunaite I, Smalinskaite L, Podkopajev A, Bironaite D, Weis CA, Marx A, Bukelskiene V, Gretz N, Grabauskiene V, Labeit D, Labeit S. PMID: 27812527; PMCID: PMC5080459.

View in: PubMed Mentions: 7 Fields:
Bio Biotechnology Med Medicine (General)
Translation:Animals Cells PHPublic Health
CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex. FEBS Lett. 2016 09; 590(18):3098-110. Zhou T, Fleming JR, Franke B, Bogomolovas J, Barsukov I, Rigden DJ, Labeit S, Mayans O. PMID: 27531639.

View in: PubMed Mentions: 15 Fields:
Bio Biochemistry
Translation:Humans Cells
Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biol. 2016 Sep; 6(9). Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O. PMID: 27683155; PMCID: PMC5043576.

View in: PubMed Mentions: 11 Fields:
Cel Cell Biology Mol Molecular Biology
Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury. Int J Cardiol. 2016 Jun 01; 212:232-4. Bogomolovas J, Gasch A, Bajoras V, Karciauskaite D, Šerpytis P, Grabauskiene V, Labeit D, Labeit S. PMID: 27043064.

View in: PubMed Mentions: 6 Fields:
Car Cardiology
Translation:Humans
Titin antibodies in "seronegative" myasthenia gravis--A new role for an old antigen. J Neuroimmunol. 2016 Mar 15; 292:108-15. Stergiou C, Lazaridis K, Zouvelou V, Tzartos J, Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, Saruhan-Direskeneli G, Durmus H, Brenner T, Vaknin A, Berrih-Aknin S, Behin A, Sharshar T, De Baets M, Losen M, Martinez-Martinez P, Kleopa KA, Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk A, Szczudlik P, Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A, Gilhus NE, Casasnovas Pons C, Pitha J, Jakubíkova M, Hanisch F, Bogomolovas J, Labeit D, Labeit S, Tzartos SJ. PMID: 26943968.

View in: PubMed Mentions: 27 Fields:
All Allergy and Immunology Neu Neurology
Translation:Humans
Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression. Biomed Res Int. 2015; 2015:273936. Bogomolovas J, Brohm K, Celutkiene J, Balciunaite G, Bironaite D, Bukelskiene V, Daunoravicus D, Witt CC, Fielitz J, Grabauskiene V, Labeit S. PMID: 25961010; PMCID: PMC4415747.

View in: PubMed Mentions: 15 Fields:
Bio Biotechnology Med Medicine (General)
Translation:Humans
Molecular mechanisms behind progressing chronic inflammatory dilated cardiomyopathy. BMC Cardiovasc Disord. 2015 Mar 26; 15:26. Bironaite D, Daunoravicius D, Bogomolovas J, Cibiras S, Vitkus D, Zurauskas E, Zasytyte I, Rucinskas K, Labeit S, Venalis A, Grabauskiene V. PMID: 25888309; PMCID: PMC4466865.

View in: PubMed Mentions: 10 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Cells
Quantification of myocardial fibrosis by digital image analysis and interactive stereology. Diagn Pathol. 2014 Jun 09; 9:114. Daunoravicius D, Besusparis J, Zurauskas E, Laurinaviciene A, Bironaite D, Pankuweit S, Plancoulaine B, Herlin P, Bogomolovas J, Grabauskiene V, Laurinavicius A. PMID: 24912374; PMCID: PMC4072260.

View in: PubMed Mentions: 17 Fields:
Pat Pathology
Translation:Humans
Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line. Open Biol. 2014 May; 4(5):140041. Bogomolovas J, Gasch A, Simkovic F, Rigden DJ, Labeit S, Mayans O. PMID: 24850911; PMCID: PMC4042850.

View in: PubMed Mentions: 36 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1. Open Biol. 2014 Mar 26; 4:130172. Franke B, Gasch A, Rodriguez D, Chami M, Khan MM, Rudolf R, Bibby J, Hanashima A, Bogomolovas J, von Castelmur E, Rigden DJ, Uson I, Labeit S, Mayans O. PMID: 24671946; PMCID: PMC3971405.

View in: PubMed Mentions: 10 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism. J Biol Chem. 2013 Feb 22; 288(8):5303-15. Anderson BR, Bogomolovas J, Labeit S, Granzier H. PMID: 23297410; PMCID: PMC3581406.

View in: PubMed Mentions: 20 Fields:
Bio Biochemistry
Translation:Animals Cells
Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways. Age (Dordr). 2013 Oct; 35(5):1663-74. Rudolf R, Bogomolovas J, Strack S, Choi KR, Khan MM, Wagner A, Brohm K, Hanashima A, Gasch A, Labeit D, Labeit S. PMID: 22956146; PMCID: PMC3776120.

View in: PubMed Mentions: 43 Fields:
Ger Geriatrics
Translation:Animals Cells
Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13608-13. von Castelmur E, Strümpfer J, Franke B, Bogomolovas J, Barbieri S, Qadota H, Konarev PV, Svergun DI, Labeit S, Benian GM, Schulten K, Mayans O. PMID: 22869697; PMCID: PMC3427058.

View in: PubMed Mentions: 11 Fields:
Sci Science
Translation:Animals Cells
Titin-actin interaction: PEVK-actin-based viscosity in a large animal. J Biomed Biotechnol. 2011; 2011:310791. Chung CS, Bogomolovas J, Gasch A, Hidalgo CG, Labeit S, Granzier HL. PMID: 22162634; PMCID: PMC3227466.

View in: PubMed Mentions: 12 Fields:
Bio Biotechnology Med Medicine (General)
Translation:Animals Cells
Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation. 2011 Aug 23; 124(8):876-85. Taylor M, Graw S, Sinagra G, Barnes C, Slavov D, Brun F, Pinamonti B, Salcedo EE, Sauer W, Pyxaras S, Anderson B, Simon B, Bogomolovas J, Labeit S, Granzier H, Mestroni L. PMID: 21810661; PMCID: PMC3167235.

View in: PubMed Mentions: 127 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Cells
Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy. J Clin Invest. 2010 Aug; 120(8):2672-83. Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H. PMID: 20592470; PMCID: PMC2912184.

View in: PubMed Mentions: 49 Fields:
Med Medicine (General)
Translation:Animals Cells
MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. J Struct Biol. 2010 May; 170(2):344-53. Moriscot AS, Baptista IL, Bogomolovas J, Witt C, Hirner S, Granzier H, Labeit S. PMID: 20149877; PMCID: PMC2856802.

View in: PubMed Mentions: 45 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
The effects of PKCalpha phosphorylation on the extensibility of titin's PEVK element. J Struct Biol. 2010 May; 170(2):270-7. Anderson BR, Bogomolovas J, Labeit S, Granzier H. PMID: 20149875; PMCID: PMC2856808.

View in: PubMed Mentions: 19 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res. 2009 Sep 25; 105(7):631-8, 17 p following 638. Hidalgo C, Hudson B, Bogomolovas J, Zhu Y, Anderson B, Greaser M, Labeit S, Granzier H. PMID: 19679839; PMCID: PMC2764991.

View in: PubMed Mentions: 138 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Animals Cells
Single molecule force spectroscopy of the cardiac titin N2B element: effects of the molecular chaperone alphaB-crystallin with disease-causing mutations. J Biol Chem. 2009 May 15; 284(20):13914-13923. Zhu Y, Bogomolovas J, Labeit S, Granzier H. PMID: 19282282; PMCID: PMC2679491.

View in: PubMed Mentions: 29 Fields:
Bio Biochemistry
Translation:Humans Cells
Screening of fusion partners for high yield expression and purification of bioactive viscotoxins. Protein Expr Purif. 2009 Mar; 64(1):16-23. Bogomolovas J, Simon B, Sattler M, Stier G. PMID: 18983922.

View in: PubMed Mentions: 71 Fields:
Mol Molecular Biology
Translation:Cells