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Immo Scheffler

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0322
La Jolla CA 92093
Phone858-534-2741
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    Collapse Research 
    Collapse Research Activities and Funding
    MOLEC GENETICS OF COMPLEX I IN MAMMALIAN MITOCHONDRIA
    NIH/NIGMS R01GM059909Jul 1, 2001 - Dec 31, 2005
    Role: Principal Investigator
    MOLECULAR GENETICS OF RESPIRATION-DEFICIENT CELLS
    NIH/NIGMS R01GM033752Aug 1, 1984 - Mar 31, 1996
    Role: Principal Investigator
    MOLECULAR CHARACTERIZATION OF A HUMAN CENTROMERE
    NIH/NIGMS R01GM018835Sep 1, 1977 - Aug 31, 1993
    Role: Principal Investigator
    Cell and Molecular Genetics Training Program
    NIH/NIGMS T32GM007240Jul 1, 1975 - Jun 30, 2020
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. Correction for Fogal et al., "Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation". Mol Cell Biol. 2017 Jul 15; 37(14). PMID: 28663271.
      View in: PubMed
    2. Potluri P, Procaccio V, Scheffler IE, Wallace DC. High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (?(-)) mutant. Biochim Biophys Acta. 2016 Aug; 1857(8):1336-1343. PMID: 26946086; PMCID: PMC4893908 [Available on 08/01/17].
    3. Scheffler IE. Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency. J Inherit Metab Dis. 2015 May; 38(3):405-15. PMID: 25224827.
      View in: PubMed
    4. Lau E, Kluger H, Varsano T, Lee K, Scheffler I, Rimm DL, Ideker T, Ronai ZA. PKCe promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Cell. 2012 Feb 03; 148(3):543-55. PMID: 22304920; PMCID: PMC3615433.
    5. Compton S, Kim C, Griner NB, Potluri P, Scheffler IE, Sen S, Jerry DJ, Schneider S, Yadava N. Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J Biol Chem. 2011 Jun 10; 286(23):20297-312. PMID: 21502317; PMCID: PMC3121470.
    6. Scheffler IE. Assembling complex I with ACAD9. Cell Metab. 2010 Sep 08; 12(3):211-2. PMID: 20816087.
      View in: PubMed
    7. Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol. 2010 Mar; 30(6):1303-18. PMID: 20100866; PMCID: PMC2832503.
    8. Dong LF, Freeman R, Liu J, Zobalova R, Marin-Hernandez A, Stantic M, Rohlena J, Valis K, Rodriguez-Enriquez S, Butcher B, Goodwin J, Brunk UT, Witting PK, Moreno-Sanchez R, Scheffler IE, Ralph SJ, Neuzil J. Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clin Cancer Res. 2009 Mar 01; 15(5):1593-600. PMID: 19223492.
      View in: PubMed
    9. Potluri P, Davila A, Ruiz-Pesini E, Mishmar D, O'Hearn S, Hancock S, Simon M, Scheffler IE, Wallace DC, Procaccio V. A novel NDUFA1 mutation leads to a progressive mitochondrial complex I-specific neurodegenerative disease. Mol Genet Metab. 2009 Apr; 96(4):189-95. PMID: 19185523; PMCID: PMC2693342.
    10. Sonoda J, Laganière J, Mehl IR, Barish GD, Chong LW, Li X, Scheffler IE, Mock DC, Bataille AR, Robert F, Lee CH, Giguère V, Evans RM. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev. 2007 Aug 01; 21(15):1909-20. PMID: 17671090; PMCID: PMC1935029.
    11. Neuzil J, Dyason JC, Freeman R, Dong LF, Prochazka L, Wang XF, Scheffler I, Ralph SJ. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J Bioenerg Biomembr. 2007 Feb; 39(1):65-72. PMID: 17294131.
      View in: PubMed
    12. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. PMID: 16636313.
      View in: PubMed
    13. Scheffler IE, Yadava N, Potluri P. Molecular genetics of complex I-deficient Chinese hamster cell lines. Biochim Biophys Acta. 2004 Dec 06; 1659(2-3):160-71. PMID: 15576048.
      View in: PubMed
    14. Potluri P, Yadava N, Scheffler IE. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur J Biochem. 2004 Aug; 271(15):3265-73. PMID: 15265046.
      View in: PubMed
    15. Ricci JE, Muñoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N, Scheffler IE, Ellisman MH, Green DR. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell. 2004 Jun 11; 117(6):773-86. PMID: 15186778.
      View in: PubMed
    16. Yadava N, Scheffler IE. Import and orientation of the MWFE protein in mitochondrial NADH-ubiquinone oxidoreductase. Mitochondrion. 2004 Jun; 4(1):1-12. PMID: 16120368.
      View in: PubMed
    17. Yadava N, Houchens T, Potluri P, Scheffler IE. Development and characterization of a conditional mitochondrial complex I assembly system. J Biol Chem. 2004 Mar 26; 279(13):12406-13. PMID: 14722084.
      View in: PubMed
    18. Albayrak T, Scherhammer V, Schoenfeld N, Braziulis E, Mund T, Bauer MK, Scheffler IE, Grimm S. The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction. Mol Biol Cell. 2003 Aug; 14(8):3082-96. PMID: 12925748; PMCID: PMC181552.
    19. de la Cruz BJ, Prieto S, Scheffler IE. The role of the 5' untranslated region (UTR) in glucose-dependent mRNA decay. Yeast. 2002 Jul; 19(10):887-902. PMID: 12112242.
      View in: PubMed
    20. Yadava N, Potluri P, Smith EN, Bisevac A, Scheffler IE. Species-specific and mutant MWFE proteins. Their effect on the assembly of a functional mammalian mitochondrial complex I. J Biol Chem. 2002 Jun 14; 277(24):21221-30. PMID: 11937507.
      View in: PubMed
    21. Scheffler IE. Mitochondria make a come back. Adv Drug Deliv Rev. 2001 Jul 02; 49(1-2):3-26. PMID: 11377800.
      View in: PubMed
    22. Scheffler IE, Yadava N. Molecular genetics of the mammalian NADH-ubiquinone oxidoreductase. J Bioenerg Biomembr. 2001 Jun; 33(3):243-50. PMID: 11695834.
      View in: PubMed
    23. Scheffler IE. A century of mitochondrial research: achievements and perspectives. Mitochondrion. 2001 Jun; 1(1):3-31. PMID: 16120266.
      View in: PubMed
    24. Scheffler IE, de la Cruz BJ, Prieto S. Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae. Int J Biochem Cell Biol. 1998 Nov; 30(11):1175-93. PMID: 9839444.
      View in: PubMed