Immo Scheffler

Title(s)Emeritus Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    MOLEC GENETICS OF COMPLEX I IN MAMMALIAN MITOCHONDRIA
    NIH R01GM059909Jul 1, 2001 - Dec 31, 2005
    Role: Principal Investigator
    MOLECULAR GENETICS OF RESPIRATION-DEFICIENT CELLS
    NIH R01GM033752Aug 1, 1984 - Mar 31, 1996
    Role: Principal Investigator
    MOLECULAR CHARACTERIZATION OF A HUMAN CENTROMERE
    NIH R01GM018835Sep 1, 1977 - Aug 31, 1993
    Role: Principal Investigator
    Cell and Molecular Genetics Training Program
    NIH T32GM007240Jul 1, 1975 - Jun 30, 2021
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction for Fogal et al., "Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation". Mol Cell Biol. 2017 07 15; 37(14). Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. PMID: 28663271.
      View in: PubMed   Mentions:    Fields:    
    2. High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (?(-)) mutant. Biochim Biophys Acta. 2016 Aug; 1857(8):1336-1343. Potluri P, Procaccio V, Scheffler IE, Wallace DC. PMID: 26946086.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency. J Inherit Metab Dis. 2015 May; 38(3):405-15. Scheffler IE. PMID: 25224827.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    4. PKCe promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Cell. 2012 Feb 03; 148(3):543-55. Lau E, Kluger H, Varsano T, Lee K, Scheffler I, Rimm DL, Ideker T, Ronai ZA. PMID: 22304920.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    5. Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J Biol Chem. 2011 Jun 10; 286(23):20297-312. Compton S, Kim C, Griner NB, Potluri P, Scheffler IE, Sen S, Jerry DJ, Schneider S, Yadava N. PMID: 21502317.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    6. Assembling complex I with ACAD9. Cell Metab. 2010 Sep 08; 12(3):211-2. Scheffler IE. PMID: 20816087.
      View in: PubMed   Mentions: 1     Fields:    
    7. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol. 2010 Mar; 30(6):1303-18. Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. PMID: 20100866.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    8. Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clin Cancer Res. 2009 Mar 01; 15(5):1593-600. Dong LF, Freeman R, Liu J, Zobalova R, Marin-Hernandez A, Stantic M, Rohlena J, Valis K, Rodriguez-Enriquez S, Butcher B, Goodwin J, Brunk UT, Witting PK, Moreno-Sanchez R, Scheffler IE, Ralph SJ, Neuzil J. PMID: 19223492.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    9. A novel NDUFA1 mutation leads to a progressive mitochondrial complex I-specific neurodegenerative disease. Mol Genet Metab. 2009 Apr; 96(4):189-95. Potluri P, Davila A, Ruiz-Pesini E, Mishmar D, O'Hearn S, Hancock S, Simon M, Scheffler IE, Wallace DC, Procaccio V. PMID: 19185523.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    10. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev. 2007 Aug 01; 21(15):1909-20. Sonoda J, Laganière J, Mehl IR, Barish GD, Chong LW, Li X, Scheffler IE, Mock DC, Bataille AR, Robert F, Lee CH, Giguère V, Evans RM. PMID: 17671090.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    11. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J Bioenerg Biomembr. 2007 Feb; 39(1):65-72. Neuzil J, Dyason JC, Freeman R, Dong LF, Prochazka L, Wang XF, Scheffler I, Ralph SJ. PMID: 17294131.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    12. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR. PMID: 16636313.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    13. Molecular genetics of complex I-deficient Chinese hamster cell lines. Biochim Biophys Acta. 2004 Dec 06; 1659(2-3):160-71. Scheffler IE, Yadava N, Potluri P. PMID: 15576048.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur J Biochem. 2004 Aug; 271(15):3265-73. Potluri P, Yadava N, Scheffler IE. PMID: 15265046.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell. 2004 Jun 11; 117(6):773-86. Ricci JE, Muñoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N, Scheffler IE, Ellisman MH, Green DR. PMID: 15186778.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    16. Import and orientation of the MWFE protein in mitochondrial NADH-ubiquinone oxidoreductase. Mitochondrion. 2004 Jun; 4(1):1-12. Yadava N, Scheffler IE. PMID: 16120368.
      View in: PubMed   Mentions: 2     Fields:    
    17. Development and characterization of a conditional mitochondrial complex I assembly system. J Biol Chem. 2004 Mar 26; 279(13):12406-13. Yadava N, Houchens T, Potluri P, Scheffler IE. PMID: 14722084.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    18. The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction. Mol Biol Cell. 2003 Aug; 14(8):3082-96. Albayrak T, Scherhammer V, Schoenfeld N, Braziulis E, Mund T, Bauer MK, Scheffler IE, Grimm S. PMID: 12925748.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    19. The role of the 5' untranslated region (UTR) in glucose-dependent mRNA decay. Yeast. 2002 Jul; 19(10):887-902. de la Cruz BJ, Prieto S, Scheffler IE. PMID: 12112242.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    20. Species-specific and mutant MWFE proteins. Their effect on the assembly of a functional mammalian mitochondrial complex I. J Biol Chem. 2002 Jun 14; 277(24):21221-30. Yadava N, Potluri P, Smith EN, Bisevac A, Scheffler IE. PMID: 11937507.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. Mitochondria make a come back. Adv Drug Deliv Rev. 2001 Jul 02; 49(1-2):3-26. Scheffler IE. PMID: 11377800.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    22. Molecular genetics of the mammalian NADH-ubiquinone oxidoreductase. J Bioenerg Biomembr. 2001 Jun; 33(3):243-50. Scheffler IE, Yadava N. PMID: 11695834.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. A century of mitochondrial research: achievements and perspectives. Mitochondrion. 2001 Jun; 1(1):3-31. Scheffler IE. PMID: 16120266.
      View in: PubMed   Mentions: 58     Fields:    
    24. Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae. Int J Biochem Cell Biol. 1998 Nov; 30(11):1175-93. Scheffler IE, de la Cruz BJ, Prieto S. PMID: 9839444.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
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