Amanda Grethe

Title(s)Associate Adjunct Professor, Psychiatry
SchoolHealth Sciences
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    Dr. Bischoff-Grethe received her Ph.D. in Computer Science with a focus upon Computational Neurobiology from the University of Southern California in 1998. She was a postdoctoral fellow and Assistant Project Scientist at UCSD before joining the UCSD faculty. She is currently an Associate Adjunct Professor in the Department of Psychiatry. Dr. Bischoff-Grethe is particularly interested in the brain's response to reward and punishment and how it relates to cognitive processing. Her research focuses upon brain function in adolescents and adults with eating disorders or histories of substance use using functional MRI, DTI, and other morphometric methods.

    Research Interests

    Dr. Bischoff-Grethe’s primary interest is reward and decision-making processing in both healthy and clinical populations using functional MRI. Currently, she leads studies examining how decision-making and probabilistic learning are altered due to the individual and combined effects of recent methamphetamine dependence and HIV infection. She also plays a prominent role in studies examining how frontostriatal processing is altered in individuals with an eating disorder. Given that eating disorders most often manifest during adolescence, a period of profound neurodevelopmental change in reward and cognitive control processes, a growing part of her research has emphasized the key differences in these processes in children and adolescents with an eating disorder. More recently, she has expanded her work to include both structural and functional connectivity analyses.

    Clinical and Teaching Focus

    Dr. Bischoff-Grethe’s clinical interests involve using neuroimaging to identify the biological and cognitive processes underlying psychopathology. The identification of the neurophenotypes associated with clinical symptoms will aid in the development of more effective treatments.

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    Collapse Research Activities and Funding
    Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders
    NIH/NIMH R01MH113588Jul 21, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Neural Dysfunction of Interoception in Adolescents Diagnosed with Anorexia Nervos
    NIH/NIMH R21MH086017May 7, 2009 - Apr 30, 2012
    Role: Principal Investigator
    Translational Methamphetamine AIDS Research Center (TMARC)
    NIH/NIDA P50DA026306Dec 1, 2008 - May 31, 2019
    Role: Co-Investigator
    The Role of Dopamine Reward Mechanisms in Motor Control
    NIH/NIDA K01DA015499Sep 5, 2003 - Dec 30, 2008
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Filoteo JV, Paul EJ, Ashby FG, Frank GK, Helie S, Rockwell R, Bischoff-Grethe A, Wierenga C, Kaye WH. Simulating category learning and set shifting deficits in patients weight-restored from anorexia nervosa. Neuropsychology. 2014 Sep; 28(5):741-51. PMID: 24799291; PMCID: PMC4143467.
    2. Wierenga C, Bischoff-Grethe A, Melrose AJ, Grenesko-Stevens E, Irvine Z, Wagner A, Simmons A, Matthews S, Yau WY, Fennema-Notestine C, Kaye WH. Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa. PLoS One. 2014; 9(3):e92017. PMID: 24651705; PMCID: PMC3961291.
    3. Bischoff-Grethe A, McCurdy D, Grenesko-Stevens E, Irvine LE, Wagner A, Yau WY, Fennema-Notestine C, Wierenga CE, Fudge JL, Delgado MR, Kaye WH. Altered brain response to reward and punishment in adolescents with Anorexia nervosa. Psychiatry Res. 2013 Dec 30; 214(3):331-40. PMID: 24148909; PMCID: PMC3880152.
    4. Yau WY, Bischoff-Grethe A, Theilmann RJ, Torres L, Wagner A, Kaye WH, Fennema-Notestine C. Alterations in white matter microstructure in women recovered from anorexia nervosa. Int J Eat Disord. 2013 Nov; 46(7):701-8. PMID: 23818167; PMCID: PMC3812403.
    5. Kaye WH, Wierenga CE, Bailer UF, Simmons AN, Wagner A, Bischoff-Grethe A. Does a shared neurobiology for foods and drugs of abuse contribute to extremes of food ingestion in anorexia and bulimia nervosa? Biol Psychiatry. 2013 May 01; 73(9):836-42. PMID: 23380716; PMCID: PMC3755487.
    6. Kaye WH, Wierenga CE, Bailer UF, Simmons AN, Bischoff-Grethe A. Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa. Trends Neurosci. 2013 Feb; 36(2):110-20. PMID: 23333342; PMCID: PMC3880159.
    7. Wagner A, Aizenstein H, Venkatraman VK, Bischoff-Grethe A, Fudge J, May JC, Frank GK, Bailer UF, Fischer L, Putnam K, Kaye WH. Altered striatal response to reward in bulimia nervosa after recovery. Int J Eat Disord. 2010 May; 43(4):289-94. PMID: 19434606; PMCID: PMC4286149.
    8. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Max JE, Bischoff-Grethe A, Lansing AE, Brown G, Strigo IA, Wu J, Paulus MP. Adolescents with major depression demonstrate increased amygdala activation. J Am Acad Child Adolesc Psychiatry. 2010 Jan; 49(1):42-51. PMID: 20215925; PMCID: PMC2935523.
    9. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Bischoff-Grethe A, Lansing AE, Wu J, Brown GG, Paulus MP. Depressed adolescents demonstrate greater subgenual anterior cingulate activity. Neuroreport. 2009 Mar 04; 20(4):440-4. PMID: 19218875; PMCID: PMC2672880.
    10. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Bischoff-Grethe A, Lansing AE, Wu J, Paulus MP. Adolescent subgenual anterior cingulate activity is related to harm avoidance. Neuroreport. 2009 Jan 07; 20(1):19-23. PMID: 19034055; PMCID: PMC2852645.
    11. Brown GG, McCarthy G, Bischoff-Grethe A, Ozyurt B, Greve D, Potkin SG, Turner JA, Notestine R, Calhoun VD, Ford JM, Mathalon D, Manoach DS, Gadde S, Glover GH, Wible CG, Belger A, Gollub RL, Lauriello J, O'Leary D, Lim KO. Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach. Schizophr Bull. 2009 Jan; 35(1):32-46. PMID: 19023127; PMCID: PMC2643949.
    12. Ford JM, Roach BJ, Jorgensen KW, Turner JA, Brown GG, Notestine R, Bischoff-Grethe A, Greve D, Wible C, Lauriello J, Belger A, Mueller BA, Calhoun V, Preda A, Keator D, O'Leary DS, Lim KO, Glover G, Potkin SG, Mathalon DH. Tuning in to the voices: a multisite FMRI study of auditory hallucinations. Schizophr Bull. 2009 Jan; 35(1):58-66. PMID: 18987102; PMCID: PMC2643968.
    13. Bischoff-Grethe A, Hazeltine E, Bergren L, Ivry RB, Grafton ST. The influence of feedback valence in associative learning. Neuroimage. 2009 Jan 01; 44(1):243-51. PMID: 18834944; PMCID: PMC2642655.
    14. Yang TT, Simmons AN, Matthews SC, Tapert SF, Bischoff-Grethe A, Frank GK, Arce E, Paulus MP. Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects. Neurosci Lett. 2007 Nov 27; 428(2-3):109-14. PMID: 18029095; PMCID: PMC2171034.
    15. Bischoff-Grethe A, Ozyurt IB, Busa E, Quinn BT, Fennema-Notestine C, Clark CP, Morris S, Bondi MW, Jernigan TL, Dale AM, Brown GG, Fischl B. A technique for the deidentification of structural brain MR images. Hum Brain Mapp. 2007 Sep; 28(9):892-903. PMID: 17295313; PMCID: PMC2408762.
    16. Smalheiser NR, Torvik VI, Bischoff-Grethe A, Burhans LB, Gabriel M, Homayouni R, Kashef A, Martone ME, Perkins GA, Price DL, Talk AC, West R. Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators. J Biomed Discov Collab. 2006 Jul 03; 1:8. PMID: 16817965; PMCID: PMC1559644.
    17. Fennema-Notestine C, Ozyurt IB, Clark CP, Morris S, Bischoff-Grethe A, Bondi MW, Jernigan TL, Fischl B, Segonne F, Shattuck DW, Leahy RM, Rex DE, Toga AW, Zou KH, Brown GG. Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: effects of diagnosis, bias correction, and slice location. Hum Brain Mapp. 2006 Feb; 27(2):99-113. PMID: 15986433; PMCID: PMC2408865.
    18. Drummond SP, Bischoff-Grethe A, Dinges DF, Ayalon L, Mednick SC, Meloy MJ. The neural basis of the psychomotor vigilance task. Sleep. 2005 Sep; 28(9):1059-68. PMID: 16268374.
      View in: PubMed
    19. Bischoff-Grethe A, Goedert KM, Willingham DT, Grafton ST. Neural substrates of response-based sequence learning using fMRI. J Cogn Neurosci. 2004 Jan-Feb; 16(1):127-38. PMID: 15006042.
      View in: PubMed
    20. Bischoff-Grethe A, Ivry RB, Grafton ST. Cerebellar involvement in response reassignment rather than attention. J Neurosci. 2002 Jan 15; 22(2):546-53. PMID: 11784801.
      View in: PubMed
    21. Bischoff-Grethe A, Martin M, Mao H, Berns GS. The context of uncertainty modulates the subcortical response to predictability. J Cogn Neurosci. 2001 Oct 01; 13(7):986-93. PMID: 11595100.
      View in: PubMed
    22. Bischoff-Grethe A, Proper SM, Mao H, Daniels KA, Berns GS. Conscious and unconscious processing of nonverbal predictability in Wernicke's area. J Neurosci. 2000 Mar 01; 20(5):1975-81. PMID: 10684898.
      View in: PubMed