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H. Kirk Hammond

Title(s)Professor In Residence, Medicine
SchoolHealth Sciences
Phone858-552-8585
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Giamouridis D, Gao MH, Lai NC, Guo T, Miyanohara A, Blankesteijn WM, Biessen EAL, Hammond HK. Urocortin2 Gene Transfer Improves Heart Function in Aged Mice. Mol Ther. 2019 Oct 18. PMID: 31676153.
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    2. Bull Melsom C, Cosson MV, Ørstavik Ø, Lai NC, Hammond HK, Osnes JB, Skomedal T, Nikolaev V, Levy FO, Krobert KA. Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6. PLoS One. 2019; 14(6):e0218110. PMID: 31173603.
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    3. Kim YC, Giamouridis D, Lai NC, Guo T, Xia B, Fu Z, Gao MH, Hammond HK. Urocortin 2 Gene Transfer Reduces the Adverse Effects of a Western Diet on Cardiac Function in Mice. Hum Gene Ther. 2019 Jun; 30(6):693-701. PMID: 30648430.
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    4. Tan Z, Giamouridis D, Lai NC, Kim YC, Guo T, Xia B, Gao MH, Hammond HK. Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain (C1C2) Attenuates Deleterious Effects of Pressure Overload. Hum Gene Ther. 2019 Jun; 30(6):682-692. PMID: 30638074.
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    5. McKirnan MD, Ichikawa Y, Zhang Z, Zemljic-Harpf AE, Fan S, Barupal DK, Patel HH, Hammond HK, Roth DM. Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction. Life Sci. 2019 Mar 15; 221:212-223. PMID: 30731143.
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    6. Giamouridis D, Gao MH, Lai NC, Tan Z, Kim YC, Guo T, Miyanohara A, Blankesteijn MW, Biessen EAL, Hammond HK. Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart. Hum Gene Ther. 2019 Jan; 30(1):10-20. PMID: 30003813.
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    7. Giamouridis D, Gao MH, Lai NC, Tan Z, Kim YC, Guo T, Miyanohara A, Blankesteijn WM, Biessen E, Hammond HK. Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC Basic Transl Sci. 2018 Apr; 3(2):249-264. PMID: 30062211.
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    8. Penny WF, Henry TD, Watkins MW, Patel AN, Hammond HK. Design of a Phase 3 trial of intracoronary administration of human adenovirus 5 encoding human adenylyl cyclase type 6 (RT-100) gene transfer in patients with heart failure with reduced left ventricular ejection fraction: The FLOURISH Clinical Trial. Am Heart J. 2018 07; 201:111-116. PMID: 29763816.
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    9. Gao MH, Lai NC, Giamouridis D, Kim YC, Guo T, Hammond HK. Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained ß-adrenergic stimulation. PLoS One. 2017; 12(8):e0181282. PMID: 28767701.
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    10. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. PMID: 28498861.
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    11. Penny WF, Hammond HK. Randomized Clinical Trials of Gene Transfer for Heart Failure with Reduced Ejection Fraction. Hum Gene Ther. 2017 05; 28(5):378-384. PMID: 28322590.
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    12. Gao MH, Lai NC, Giamouridis D, Kim YC, Tan Z, Guo T, Dillmann WH, Suarez J, Hammond HK. Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation. JACC Basic Transl Sci. 2016 Dec; 1(7):617-629. PMID: 28670631.
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    13. Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK. One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight. 2016 09 22; 1(15):e88322. PMID: 27699250.
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    14. Pandey AK, Penny WF, Bhargava V, Lai NC, Xu R, Hammond HK. Clinical Evaluation of Heart Failure: Agreement among Tests. PLoS One. 2016; 11(8):e0161536. PMID: 27537778.
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    15. Hammond HK, Penny WF, Traverse JH, Henry TD, Watkins MW, Yancy CW, Sweis RN, Adler ED, Patel AN, Murray DR, Ross RS, Bhargava V, Maisel A, Barnard DD, Lai NC, Dalton ND, Lee ML, Narayan SM, Blanchard DG, Gao MH. Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial. JAMA Cardiol. 2016 05 01; 1(2):163-71. PMID: 27437887.
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    16. Lai NC, Gao MH, Giamouridis D, Suarez J, Miyanohara A, Parikh J, Hightower S, Guo T, Dillmann W, Kim YC, Diaz-Juarez J, Hammond HK. Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice. Hum Gene Ther. 2015 Jun; 26(6):347-56. PMID: 25760560.
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    17. Lee KL, Hoey DA, Spasic M, Tang T, Hammond HK, Jacobs CR. Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo. FASEB J. 2014 Mar; 28(3):1157-65. PMID: 24277577.
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    18. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324.
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    19. Gao MH, Lai NC, Tang T, Guo T, Tang R, Chun BJ, Wang H, Dalton NN, Suarez J, Dillmann WH, Hammond HK. Preserved cardiac function despite marked impairment of cAMP generation. PLoS One. 2013; 8(9):e72151. PMID: 24147149.
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    20. Gao MH, Lai NC, Miyanohara A, Schilling JM, Suarez J, Tang T, Guo T, Tang R, Parikh J, Giamouridis D, Dillmann WH, Patel HH, Roth DM, Dalton ND, Hammond HK. Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice. Hum Gene Ther. 2013 Sep; 24(9):777-85. PMID: 23931341.
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    21. Timofeyev V, Myers RE, Kim HJ, Woltz RL, Sirish P, Heiserman JP, Li N, Singapuri A, Tang T, Yarov-Yarovoy V, Yamoah EN, Hammond HK, Chiamvimonvat N. Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes. Circ Res. 2013 Jun 07; 112(12):1567-76. PMID: 23609114.
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    22. Tang T, Lai NC, Wright AT, Gao MH, Lee P, Guo T, Tang R, McCulloch AD, Hammond HK. Adenylyl cyclase 6 deletion increases mortality during sustained ß-adrenergic receptor stimulation. J Mol Cell Cardiol. 2013 Jul; 60:60-7. PMID: 23587598.
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    23. Tang T, Hammond HK. Gene transfer for congestive heart failure: update 2013. Transl Res. 2013 Apr; 161(4):313-20. PMID: 23261978.
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    24. Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Am J Pathol. 2013 Jan; 182(1):96-106. PMID: 23123217.
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    25. Fang H, Lai NC, Gao MH, Miyanohara A, Roth DM, Tang T, Hammond HK. Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer. Hum Gene Ther Methods. 2012 Aug; 23(4):234-41. PMID: 22966786.
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    26. Tang T, Gao MH, Hammond HK. Prospects for gene transfer for clinical heart failure. Gene Ther. 2012 Jun; 19(6):606-12. PMID: 22534469.
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    27. Zhang L, McCabe T, Condra JH, Ni YG, Peterson LB, Wang W, Strack AM, Wang F, Pandit S, Hammond H, Wood D, Lewis D, Rosa R, Mendoza V, Cumiskey AM, Johns DG, Hansen BC, Shen X, Geoghagen N, Jensen K, Zhu L, Wietecha K, Wisniewski D, Huang L, Zhao JZ, Ernst R, Hampton R, Haytko P, Ansbro F, Chilewski S, Chin J, Mitnaul LJ, Pellacani A, Sparrow CP, An Z, Strohl W, Hubbard B, Plump AS, Blom D, Sitlani A. An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes. Int J Biol Sci. 2012; 8(3):310-27. PMID: 22355267.
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    28. Lai NC, Tang T, Gao MH, Saito M, Miyanohara A, Hammond HK. Improved function of the failing rat heart by regulated expression of insulin-like growth factor I via intramuscular gene transfer. Hum Gene Ther. 2012 Mar; 23(3):255-61. PMID: 22017392.
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    29. Dai B, Huang W, Xu M, Millard RW, Gao MH, Hammond HK, Menick DR, Ashraf M, Wang Y. Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function. J Am Coll Cardiol. 2011 Nov 08; 58(20):2118-27. PMID: 22051336.
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    30. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. PMID: 21982317.
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    31. Tang T, Hammond HK, Firth A, Yang Y, Gao MH, Yuan JX, Lai NC. Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts. J Am Coll Cardiol. 2011 May 03; 57(18):1846-55. PMID: 21527160.
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    32. Gao MH, Hammond HK. Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer. J Mol Cell Cardiol. 2011 May; 50(5):751-8. PMID: 21354173.
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    33. Aldehni F, Tang T, Madsen K, Plattner M, Schreiber A, Friis UG, Hammond HK, Han PL, Schweda F. Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6. Hypertension. 2011 Mar; 57(3):460-8. PMID: 21282557.
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    34. Sugano Y, Lai NC, Gao MH, Firth AL, Yuan JX, Lew WY, Hammond HK. Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart. Biochem Biophys Res Commun. 2011 Feb 18; 405(3):349-55. PMID: 21195051.
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    35. Gao MH, Tang T, Lai NC, Miyanohara A, Guo T, Tang R, Firth AL, Yuan JX, Hammond HK. Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Mol Pharmacol. 2011 Mar; 79(3):381-8. PMID: 21127130.
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    36. Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol. 2010 Dec; 21(12):2059-68. PMID: 20864687.
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    37. Timofeyev V, Porter CA, Tuteja D, Qiu H, Li N, Tang T, Singapuri A, Han PL, Lopez JE, Hammond HK, Chiamvimonvat N. Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1459-67. PMID: 20709863.
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    38. Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y. Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. Circ Res. 2010 Jun 25; 106(12):1882-92. PMID: 20431059.
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    39. Tang T, Lai NC, Hammond HK, Roth DM, Yang Y, Guo T, Gao MH. Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice. J Am Coll Cardiol. 2010 Apr 06; 55(14):1476-86. PMID: 20359598.
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    40. Gao MH, Tang T, Miyanohara A, Feramisco JR, Hammond HK. beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling. Cell Signal. 2010 Apr; 22(4):584-9. PMID: 19932173.
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    41. Hammond HK, Tang T. Gene therapy for myocardial infarction-associated congestive heart failure: how far have we got? Dialog Cardiovasc Med. 2009; 14(1):27-51. PMID: 21701699.
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    42. Tang T, Gao MH, Miyanohara A, Hammond HK. Galphaq reduces cAMP production by decreasing Galphas protein abundance. Biochem Biophys Res Commun. 2008 Dec 12; 377(2):679-684. PMID: 18948082.
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    43. Gao MH, Tang T, Guo T, Miyanohara A, Yajima T, Pestonjamasp K, Feramisco JR, Hammond HK. Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes. J Biol Chem. 2008 Nov 28; 283(48):33527-35. PMID: 18838385.
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    44. Lai NC, Tang T, Gao MH, Saito M, Takahashi T, Roth DM, Hammond HK. Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice. J Am Coll Cardiol. 2008 Apr 15; 51(15):1490-7. PMID: 18402905.
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    45. Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK. Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 01; 117(1):61-9. PMID: 18071070.
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    46. Hammond HK. Skeletal muscle-derived stem cell transplantation: angiogenesis is required for improved left ventricular function. J Am Coll Cardiol. 2007 Oct 23; 50(17):1685-7. PMID: 17950151.
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    47. Phan HM, Gao MH, Lai NC, Tang T, Hammond HK. New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Trends Cardiovasc Med. 2007 Oct; 17(7):215-21. PMID: 17936202.
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    48. Tang T, Hammond HK. Cell-based GATA4 cardiac gene transfer using cell-penetrating peptide. Circ Res. 2007 Jun 08; 100(11):1540-2. PMID: 17556666.
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    49. Hammond HK. Adenylyl cyclase gene transfer in heart failure. Ann N Y Acad Sci. 2006 Oct; 1080:426-36. PMID: 17132799.
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    50. Rebolledo B, Lai NC, Gao MH, Takahashi T, Roth DM, Baird SM, Hammond HK. Adenylylcyclase gene transfer increases function of the failing heart. Hum Gene Ther. 2006 Oct; 17(10):1043-8. PMID: 17007567.
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    51. Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, Saito M, Lew WY, Clopton P, Hammond HK. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation. 2006 Aug 01; 114(5):388-96. PMID: 16864723.
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    52. Sastry A, Arnold E, Gurji H, Iwasa A, Bui H, Hassankhani A, Patel HH, Feramisco JR, Roth DM, Lai NC, Hammond HK, Narayan SM. Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction. J Am Coll Cardiol. 2006 Aug 01; 48(3):559-65. PMID: 16875984.
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    53. Timofeyev V, He Y, Tuteja D, Zhang Q, Roth DM, Hammond HK, Chiamvimonvat N. Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy. J Mol Cell Cardiol. 2006 Jul; 41(1):170-81. PMID: 16750219.
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    54. Roth DA, McKirnan MD, Canestrelli I, Gao MH, Dalton N, Lai NC, Roth DM, Hammond HK. Intracoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus. Hum Gene Ther. 2006 Feb; 17(2):230-8. PMID: 16454656.
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    55. Gao MH, Lai NC, Hammond HK. Signal peptide increases the efficacy of angiogenic gene transfer for treatment of myocardial ischemia. Hum Gene Ther. 2005 Sep; 16(9):1058-64. PMID: 16149904.
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    56. Hammond HK. Why FRET? Focus on "beta-Adrenergic and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes using a FRET-based biosensor". Am J Physiol Cell Physiol. 2005 Aug; 289(2):C246-7. PMID: 16002624.
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    57. Kaspar BK, Roth DM, Lai NC, Drumm JD, Erickson DA, McKirnan MD, Hammond HK. Myocardial gene transfer and long-term expression following intracoronary delivery of adeno-associated virus. J Gene Med. 2005 Mar; 7(3):316-24. PMID: 15515115.
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    58. Chen HH, Zhan X, Kumar A, Du X, Hammond H, Cheng L, Yang X. Detection of dual-gene expression in arteries using an optical imaging method. J Biomed Opt. 2004 Nov-Dec; 9(6):1223-9. PMID: 15568943.
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    59. Roth DM, Lai NC, Gao MH, Fine S, McKirnan MD, Roth DA, Hammond HK. Nitroprusside increases gene transfer associated with intracoronary delivery of adenovirus. Hum Gene Ther. 2004 Oct; 15(10):989-94. PMID: 15585114.
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    60. Lai NC, Roth DM, Gao MH, Tang T, Dalton N, Lai YY, Spellman M, Clopton P, Hammond HK. Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure. Circulation. 2004 Jul 20; 110(3):330-6. PMID: 15249510.
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    61. Tang T, Gao MH, Roth DM, Guo T, Hammond HK. Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1906-12. PMID: 15242835.
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    62. Gao MH, Tang T, Guo T, Sun SQ, Feramisco JR, Hammond HK. Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3. J Biol Chem. 2004 Sep 10; 279(37):38797-802. PMID: 15231818.
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    63. Penny WF, Hammond HK. Clinical use of intracoronary gene transfer of fibroblast growth factor for coronary artery disease. Curr Gene Ther. 2004 Jun; 4(2):225-30. PMID: 15180588.
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    64. Gao MH, Lai NC, McKirnan MD, Roth DA, Rubanyi GM, Dalton N, Roth DM, Hammond HK. Increased regional function and perfusion after intracoronary delivery of adenovirus encoding fibroblast growth factor 4: report of preclinical data. Hum Gene Ther. 2004 Jun; 15(6):574-87. PMID: 15212716.
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    65. Roth DM, Lai NC, Gao MH, Drumm JD, Jimenez J, Feramisco JR, Hammond HK. Indirect intracoronary delivery of adenovirus encoding adenylyl cyclase increases left ventricular contractile function in mice. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H172-7. PMID: 15001445.
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    66. Takahashi T, Anzai T, Yoshikawa T, Maekawa Y, Mahara K, Iwata M, Hammond HK, Ogawa S. Angiotensin receptor blockade improves myocardial beta-adrenergic receptor signaling in postinfarction left ventricular remodeling: a possible link between beta-adrenergic receptor kinase-1 and protein kinase C epsilon isoform. J Am Coll Cardiol. 2004 Jan 07; 43(1):125-32. PMID: 14715194.
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    67. Roth DM, Drumm JD, Bhargava V, Swaney JS, Gao MH, Hammond HK. Cardiac-directed expression of adenylyl cyclase and heart rate regulation. Basic Res Cardiol. 2003 Nov; 98(6):380-7. PMID: 14556083.
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    68. Gao MH, Bayat H, Roth DM, Yao Zhou J, Drumm J, Burhan J, Hammond HK. Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function. Cardiovasc Res. 2002 Nov; 56(2):197-204. PMID: 12393090.
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    69. Bayat H, Swaney JS, Ander AN, Dalton N, Kennedy BP, Hammond HK, Roth DM. Progressive heart failure after myocardial infarction in mice. Basic Res Cardiol. 2002 May; 97(3):206-13. PMID: 12061390.
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    70. Roth DM, Bayat H, Drumm JD, Gao MH, Swaney JS, Ander A, Hammond HK. Adenylyl cyclase increases survival in cardiomyopathy. Circulation. 2002 Apr 23; 105(16):1989-94. PMID: 11997288.
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    71. Grines CL, Watkins MW, Helmer G, Penny W, Brinker J, Marmur JD, West A, Rade JJ, Marrott P, Hammond HK, Engler RL. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris. Circulation. 2002 Mar 19; 105(11):1291-7. PMID: 11901038.
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    72. Hammond HK, McKirnan MD. Angiogenic gene therapy for heart disease: a review of animal studies and clinical trials. Cardiovasc Res. 2001 Feb 16; 49(3):561-7. PMID: 11166269.
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    73. Roth DM, Gao MH, Lai NC, Drumm J, Dalton N, Zhou JY, Zhu J, Entrikin D, Hammond HK. Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation. 1999 Jun 22; 99(24):3099-102. PMID: 10377071.
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    74. Anzai T, Lai NC, Gao M, Hammond HK. Dissociation between regional dysfunction and beta-adrenergic receptor signaling in heart failure. Am J Physiol. 1998 10; 275(4):H1267-73. PMID: 9746475.
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    75. Gao M, Ping P, Post S, Insel PA, Tang R, Hammond HK. Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):1038-43. PMID: 9448281.
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    76. Hammond HK, Ping P, Insel PA. Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist. Adv Pharmacol. 1998; 42:507-10. PMID: 9327951.
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    77. Ping P, Anzai T, Gao M, Hammond HK. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol. 1997 Aug; 273(2 Pt 2):H707-17. PMID: 9277487.
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    78. Helmer GA, McKirnan MD, Shabetai R, Boss GR, Ross J, Hammond HK. Regional deficits of myocardial blood flow and function in left ventricular pacing-induced heart failure. Circulation. 1996 Nov 01; 94(9):2260-7. PMID: 8901681.
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    79. Lew WY, Yasuda S, Yuan T, Hammond HK. Endotoxin-induced cardiac depression is associated with decreased cardiac dihydropyridine receptors in rabbits. J Mol Cell Cardiol. 1996 Jun; 28(6):1367-71. PMID: 8782078.
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    80. Giordano FJ, Ping P, McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O, Hammond HK. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med. 1996 May; 2(5):534-9. PMID: 8616711.
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    81. Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. J Clin Invest. 1995 Mar; 95(3):1271-80. PMID: 7883975.
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    82. Eising GP, Hammond HK, Helmer GA, Gilpin E, Ross J. Force-frequency relations during heart failure in pigs. Am J Physiol. 1994 Dec; 267(6 Pt 2):H2516-22. PMID: 7810747.
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    83. Ping P, Hammond HK. Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts. Am J Physiol. 1994 Nov; 267(5 Pt 2):H2079-85. PMID: 7977840.
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    84. Hammond HK, McKirnan MD. Effects of dobutamine and arbutamine on regional myocardial function in a porcine model of myocardial ischemia. J Am Coll Cardiol. 1994 Feb; 23(2):475-82. PMID: 8294703.
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    85. Hammond HK, Roth DA, McKirnan MD, Ping P. Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia. J Clin Invest. 1993 Dec; 92(6):2644-52. PMID: 8254020.
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    86. Roth DA, Urasawa K, Helmer GA, Hammond HK. Downregulation of cardiac guanosine 5'-triphosphate-binding proteins in right atrium and left ventricle in pacing-induced congestive heart failure. J Clin Invest. 1993 Mar; 91(3):939-49. PMID: 8383705.
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    87. Hammond HK, White FC, Bhargava V, Shabetai R. Heart size and maximal cardiac output are limited by the pericardium. Am J Physiol. 1992 Dec; 263(6 Pt 2):H1675-81. PMID: 1481894.
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    88. Shabetai R, Hammond HK, Lai C. The role of the pericardium in conditioning the effects of physical training. Chest. 1992 May; 101(5 Suppl):326S-329S. PMID: 1576859.
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    89. Hammond HK, Roth DA, Ford CE, Stamnas GW, Ziegler MG, Ennis C. Myocardial adrenergic denervation supersensitivity depends on a postreceptor mechanism not linked with increased cAMP production. Circulation. 1992 Feb; 85(2):666-79. PMID: 1310452.
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    90. Breisch EA, White FC, Hammond HK, Flynn S, Bloor CM. Myocardial characteristics of thyroxine stimulated hypertrophy. A structural and functional study. Basic Res Cardiol. 1989 Jul-Aug; 84(4):345-58. PMID: 2530972.
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    91. Hammond HK, Ransnas LA, Insel PA. Noncoordinate regulation of cardiac Gs protein and beta-adrenergic receptors by a physiological stimulus, chronic dynamic exercise. J Clin Invest. 1988 Dec; 82(6):2168-71. PMID: 2848869.
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