H Hammond

Title(s)Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Urocortin-2 Gene Transfer for Type 1 Diabetes and Associated LV Dysfunction
    NIH R42HL144299Sep 20, 2019 - Mar 20, 2021
    Role: Principal Investigator
    ShEEP Request for Comprehensive Lab Animal Monitoring System (CLAMS) / Oxy CLAMS
    NIH IS1BX004783Jan 1, 2019 - Sep 30, 2019
    Role: Principal Investigator
    Urocortin 2 Gene Transfer for Heart Failure with Preserved Ejection Fraction
    NIH I01BX003774Apr 1, 2017 - Mar 31, 2025
    Role: Principal Investigator
    Urocortin-2 Gene Transfer for CHF: a Paracrine Approach Using Intravenous AAV8
    NIH R42HL122038May 1, 2014 - Nov 30, 2019
    Role: Principal Investigator
    Translational Studies of Paracrine CV Gene Transfer
    NIH I01BX001515Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Translational Studies of AAV Gene Transfer for CHF
    NIH R01HL088426May 1, 2008 - Apr 30, 2012
    Role: Principal Investigator
    Mechanisms of Adenylyl Cyclase Effects in the Heart
    NIH R01HL081741Sep 1, 2005 - Dec 31, 2015
    Role: Principal Investigator
    Discovery and Development of Therapeutic Genes for CHF
    NIH P01HL066941Sep 29, 2000 - Jun 30, 2020
    Role: Principal Investigator
    NIH K04HL002812Aug 24, 1992 - Jun 30, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of Urocortin 2 Gene Transfer on Glucose Disposal in Insulin-Resistant db/db Mice on Metformin. Hum Gene Ther. 2023 08; 34(15-16):732-741. Gao MH, Giamouridis D, Lai NC, Guo T, Hammond HK. PMID: 37433214; PMCID: PMC10457654.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina. Sci Rep. 2023 05 01; 13(1):7075. Mathur PD, Zou J, Neiswanger G, Zhu D, Wang Y, Almishaal AA, Vashist D, Hammond HK, Park AH, Yang J. PMID: 37127773; PMCID: PMC10151359.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Impact of blood factors on endothelial cell metabolism and function in two diverse heart failure models. PLoS One. 2023; 18(2):e0281550. Song Y, Leem J, Dhanani M, McKirnan MD, Ichikawa Y, Braza J, Harrington EO, Hammond HK, Roth DM, Patel HH. PMID: 36780477; PMCID: PMC9924994.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Urocortin 2 Gene Transfer for Systolic and Diastolic Dysfunction Due to Chronically Increased Left Ventricular Pressure. Hum Gene Ther. 2022 Oct; 33(19-20):1091-1100. Lai NC, Tan Z, Giamouridis D, Gao MH, Hammond HK. PMID: 36053712; PMCID: PMC9595638.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2. Front Immunol. 2022; 13:980435. Ji Y, Zhang Q, Cheng L, Ge J, Wang R, Fang M, Mucker EM, Chen P, Ma J, Zhang R, Li C, Hammond H, Baracco L, Holbrook M, Frieman M, Zhang Z, Wang X, Hooper JW, Zhang L, Zhu Q. PMID: 36189212; PMCID: PMC9518701.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:220-233. Gao MH, Giamouridis D, Lai NC, Guo T, Xia B, Kim YC, Huu VAN, Skowronska-Krawczyk D, Lantier L, Bhargava R, Hammond HK. PMID: 31970200; PMCID: PMC6965520.
      View in: PubMed   Mentions: 3  
    7. Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance. PLoS One. 2019; 14(12):e0224428. Kim YC, Truax AD, Giamouridis D, Lai NC, Guo T, Hammond HK, Gao MH. PMID: 31790421; PMCID: PMC6886859.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice. Mol Ther. 2020 01 08; 28(1):180-188. Giamouridis D, Gao MH, Lai NC, Guo T, Miyanohara A, Blankesteijn WM, Biessen EAL, Hammond HK. PMID: 31676153; PMCID: PMC6953892.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6. PLoS One. 2019; 14(6):e0218110. Bull Melsom C, Cosson MV, Ørstavik Ø, Lai NC, Hammond HK, Osnes JB, Skomedal T, Nikolaev V, Levy FO, Krobert KA. PMID: 31173603; PMCID: PMC6556981.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Urocortin 2 Gene Transfer Reduces the Adverse Effects of a Western Diet on Cardiac Function in Mice. Hum Gene Ther. 2019 06; 30(6):693-701. Kim YC, Giamouridis D, Lai NC, Guo T, Xia B, Fu Z, Gao MH, Hammond HK. PMID: 30648430; PMCID: PMC6589493.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain (C1C2) Attenuates Deleterious Effects of Pressure Overload. Hum Gene Ther. 2019 06; 30(6):682-692. Tan Z, Giamouridis D, Lai NC, Kim YC, Guo T, Xia B, Gao MH, Hammond HK. PMID: 30638074; PMCID: PMC6589496.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction. Life Sci. 2019 Mar 15; 221:212-223. McKirnan MD, Ichikawa Y, Zhang Z, Zemljic-Harpf AE, Fan S, Barupal DK, Patel HH, Hammond HK, Roth DM. PMID: 30731143; PMCID: PMC6445392.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    13. Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart. Hum Gene Ther. 2019 01; 30(1):10-20. Giamouridis D, Gao MH, Lai NC, Tan Z, Kim YC, Guo T, Miyanohara A, Blankesteijn MW, Biessen EAL, Hammond HK. PMID: 30003813; PMCID: PMC6343192.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC Basic Transl Sci. 2018 Apr; 3(2):249-264. Giamouridis D, Gao MH, Lai NC, Tan Z, Kim YC, Guo T, Miyanohara A, Blankesteijn WM, Biessen E, Hammond HK. PMID: 30062211; PMCID: PMC6059348.
      View in: PubMed   Mentions: 13  
    15. Design of a Phase 3 trial of intracoronary administration of human adenovirus 5 encoding human adenylyl cyclase type 6 (RT-100) gene transfer in patients with heart failure with reduced left ventricular ejection fraction: The FLOURISH Clinical Trial. Am Heart J. 2018 07; 201:111-116. Penny WF, Henry TD, Watkins MW, Patel AN, Hammond HK. PMID: 29763816.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation. PLoS One. 2017; 12(8):e0181282. Gao MH, Lai NC, Giamouridis D, Kim YC, Guo T, Hammond HK. PMID: 28767701; PMCID: PMC5540275.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    17. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM. PMID: 28498861; PMCID: PMC5428970.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    18. Randomized Clinical Trials of Gene Transfer for Heart Failure with Reduced Ejection Fraction. Hum Gene Ther. 2017 05; 28(5):378-384. Penny WF, Hammond HK. PMID: 28322590; PMCID: PMC5444414.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    19. Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation. JACC Basic Transl Sci. 2016 Dec; 1(7):617-629. Gao MH, Lai NC, Giamouridis D, Kim YC, Tan Z, Guo T, Dillmann WH, Suarez J, Hammond HK. PMID: 28670631; PMCID: PMC5490496.
      View in: PubMed   Mentions: 7  
    20. One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight. 2016 09 22; 1(15):e88322. Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK. PMID: 27699250; PMCID: PMC5033760.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    21. Clinical Evaluation of Heart Failure: Agreement among Tests. PLoS One. 2016; 11(8):e0161536. Pandey AK, Penny WF, Bhargava V, Lai NC, Xu R, Hammond HK. PMID: 27537778; PMCID: PMC4990285.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial. JAMA Cardiol. 2016 05 01; 1(2):163-71. Hammond HK, Penny WF, Traverse JH, Henry TD, Watkins MW, Yancy CW, Sweis RN, Adler ED, Patel AN, Murray DR, Ross RS, Bhargava V, Maisel A, Barnard DD, Lai NC, Dalton ND, Lee ML, Narayan SM, Blanchard DG, Gao MH. PMID: 27437887; PMCID: PMC5535743.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCellsCTClinical Trials
    23. Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice. Hum Gene Ther. 2015 Jun; 26(6):347-56. Lai NC, Gao MH, Giamouridis D, Suarez J, Miyanohara A, Parikh J, Hightower S, Guo T, Dillmann W, Kim YC, Diaz-Juarez J, Hammond HK. PMID: 25760560; PMCID: PMC4492611.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    24. Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo. FASEB J. 2014 Mar; 28(3):1157-65. Lee KL, Hoey DA, Spasic M, Tang T, Hammond HK, Jacobs CR. PMID: 24277577; PMCID: PMC3929676.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    25. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. PMID: 24091324; PMCID: PMC3784521.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    26. Preserved cardiac function despite marked impairment of cAMP generation. PLoS One. 2013; 8(9):e72151. Gao MH, Lai NC, Tang T, Guo T, Tang R, Chun BJ, Wang H, Dalton NN, Suarez J, Dillmann WH, Hammond HK. PMID: 24147149; PMCID: PMC3797917.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    27. Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice. Hum Gene Ther. 2013 Sep; 24(9):777-85. Gao MH, Lai NC, Miyanohara A, Schilling JM, Suarez J, Tang T, Guo T, Tang R, Parikh J, Giamouridis D, Dillmann WH, Patel HH, Roth DM, Dalton ND, Hammond HK. PMID: 23931341; PMCID: PMC3768340.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes. Circ Res. 2013 Jun 07; 112(12):1567-76. Timofeyev V, Myers RE, Kim HJ, Woltz RL, Sirish P, Heiserman JP, Li N, Singapuri A, Tang T, Yarov-Yarovoy V, Yamoah EN, Hammond HK, Chiamvimonvat N. PMID: 23609114; PMCID: PMC3751398.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    29. Adenylyl cyclase 6 deletion increases mortality during sustained β-adrenergic receptor stimulation. J Mol Cell Cardiol. 2013 Jul; 60:60-7. Tang T, Lai NC, Wright AT, Gao MH, Lee P, Guo T, Tang R, McCulloch AD, Hammond HK. PMID: 23587598; PMCID: PMC3987812.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    30. Gene transfer for congestive heart failure: update 2013. Transl Res. 2013 Apr; 161(4):313-20. Tang T, Hammond HK. PMID: 23261978; PMCID: PMC3602385.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Am J Pathol. 2013 Jan; 182(1):96-106. Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V. PMID: 23123217; PMCID: PMC3532715.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    32. Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer. Hum Gene Ther Methods. 2012 Aug; 23(4):234-41. Fang H, Lai NC, Gao MH, Miyanohara A, Roth DM, Tang T, Hammond HK. PMID: 22966786; PMCID: PMC3555516.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    33. Prospects for gene transfer for clinical heart failure. Gene Ther. 2012 Jun; 19(6):606-12. Tang T, Gao MH, Hammond HK. PMID: 22534469; PMCID: PMC3555515.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    34. An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes. Int J Biol Sci. 2012; 8(3):310-27. Zhang L, McCabe T, Condra JH, Ni YG, Peterson LB, Wang W, Strack AM, Wang F, Pandit S, Hammond H, Wood D, Lewis D, Rosa R, Mendoza V, Cumiskey AM, Johns DG, Hansen BC, Shen X, Geoghagen N, Jensen K, Zhu L, Wietecha K, Wisniewski D, Huang L, Zhao JZ, Ernst R, Hampton R, Haytko P, Ansbro F, Chilewski S, Chin J, Mitnaul LJ, Pellacani A, Sparrow CP, An Z, Strohl W, Hubbard B, Plump AS, Blom D, Sitlani A. PMID: 22355267; PMCID: PMC3282994.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    35. Improved function of the failing rat heart by regulated expression of insulin-like growth factor I via intramuscular gene transfer. Hum Gene Ther. 2012 Mar; 23(3):255-61. Lai NC, Tang T, Gao MH, Saito M, Miyanohara A, Hammond HK. PMID: 22017392; PMCID: PMC3300080.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    36. Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function. J Am Coll Cardiol. 2011 Nov 08; 58(20):2118-27. Dai B, Huang W, Xu M, Millard RW, Gao MH, Hammond HK, Menick DR, Ashraf M, Wang Y. PMID: 22051336; PMCID: PMC3342759.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    37. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. PMID: 21982317; PMCID: PMC3230644.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    38. Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts. J Am Coll Cardiol. 2011 May 03; 57(18):1846-55. Tang T, Hammond HK, Firth A, Yang Y, Gao MH, Yuan JX, Lai NC. PMID: 21527160; PMCID: PMC3087976.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer. J Mol Cell Cardiol. 2011 May; 50(5):751-8. Gao MH, Hammond HK. PMID: 21354173; PMCID: PMC3095111.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    40. Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6. Hypertension. 2011 Mar; 57(3):460-8. Aldehni F, Tang T, Madsen K, Plattner M, Schreiber A, Friis UG, Hammond HK, Han PL, Schweda F. PMID: 21282557; PMCID: PMC3106204.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    41. Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart. Biochem Biophys Res Commun. 2011 Feb 18; 405(3):349-55. Sugano Y, Lai NC, Gao MH, Firth AL, Yuan JX, Lew WY, Hammond HK. PMID: 21195051; PMCID: PMC3219303.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    42. Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Mol Pharmacol. 2011 Mar; 79(3):381-8. Gao MH, Tang T, Lai NC, Miyanohara A, Guo T, Tang R, Firth AL, Yuan JX, Hammond HK. PMID: 21127130; PMCID: PMC3061356.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    43. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol. 2010 Dec; 21(12):2059-68. Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V. PMID: 20864687; PMCID: PMC3014019.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    44. Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1459-67. Timofeyev V, Porter CA, Tuteja D, Qiu H, Li N, Tang T, Singapuri A, Han PL, Lopez JE, Hammond HK, Chiamvimonvat N. PMID: 20709863; PMCID: PMC2993201.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    45. Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. Circ Res. 2010 Jun 25; 106(12):1882-92. Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y. PMID: 20431059; PMCID: PMC2892563.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    46. Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice. J Am Coll Cardiol. 2010 Apr 06; 55(14):1476-86. Tang T, Lai NC, Hammond HK, Roth DM, Yang Y, Guo T, Gao MH. PMID: 20359598; PMCID: PMC3081694.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    47. beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling. Cell Signal. 2010 Apr; 22(4):584-9. Gao MH, Tang T, Miyanohara A, Feramisco JR, Hammond HK. PMID: 19932173; PMCID: PMC2815038.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    48. Gene therapy for myocardial infarction-associated congestive heart failure: how far have we got? Dialog Cardiovasc Med. 2009; 14(1):27-51. Hammond HK, Tang T. PMID: 21701699; PMCID: PMC3119547.
      View in: PubMed   Mentions:
    49. Galphaq reduces cAMP production by decreasing Galphas protein abundance. Biochem Biophys Res Commun. 2008 Dec 12; 377(2):679-684. Tang T, Gao MH, Miyanohara A, Hammond HK. PMID: 18948082; PMCID: PMC2688725.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes. J Biol Chem. 2008 Nov 28; 283(48):33527-35. Gao MH, Tang T, Guo T, Miyanohara A, Yajima T, Pestonjamasp K, Feramisco JR, Hammond HK. PMID: 18838385; PMCID: PMC2586283.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    51. Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice. J Am Coll Cardiol. 2008 Apr 15; 51(15):1490-7. Lai NC, Tang T, Gao MH, Saito M, Takahashi T, Roth DM, Hammond HK. PMID: 18402905; PMCID: PMC3095112.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    52. Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 01; 117(1):61-9. Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK. PMID: 18071070.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    53. Skeletal muscle-derived stem cell transplantation: angiogenesis is required for improved left ventricular function. J Am Coll Cardiol. 2007 Oct 23; 50(17):1685-7. Hammond HK. PMID: 17950151.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    54. New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Trends Cardiovasc Med. 2007 Oct; 17(7):215-21. Phan HM, Gao MH, Lai NC, Tang T, Hammond HK. PMID: 17936202; PMCID: PMC2278010.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    55. Cell-based GATA4 cardiac gene transfer using cell-penetrating peptide. Circ Res. 2007 Jun 08; 100(11):1540-2. Tang T, Hammond HK. PMID: 17556666.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    56. Adenylyl cyclase gene transfer in heart failure. Ann N Y Acad Sci. 2006 Oct; 1080:426-36. Hammond HK. PMID: 17132799.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    57. Adenylylcyclase gene transfer increases function of the failing heart. Hum Gene Ther. 2006 Oct; 17(10):1043-8. Rebolledo B, Lai NC, Gao MH, Takahashi T, Roth DM, Baird SM, Hammond HK. PMID: 17007567.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    58. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation. 2006 Aug 01; 114(5):388-96. Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, Saito M, Lew WY, Clopton P, Hammond HK. PMID: 16864723.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    59. Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction. J Am Coll Cardiol. 2006 Aug 01; 48(3):559-65. Sastry A, Arnold E, Gurji H, Iwasa A, Bui H, Hassankhani A, Patel HH, Feramisco JR, Roth DM, Lai NC, Hammond HK, Narayan SM. PMID: 16875984.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    60. Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy. J Mol Cell Cardiol. 2006 Jul; 41(1):170-81. Timofeyev V, He Y, Tuteja D, Zhang Q, Roth DM, Hammond HK, Chiamvimonvat N. PMID: 16750219.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    61. Intracoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus. Hum Gene Ther. 2006 Feb; 17(2):230-8. Roth DA, McKirnan MD, Canestrelli I, Gao MH, Dalton N, Lai NC, Roth DM, Hammond HK. PMID: 16454656.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    62. Signal peptide increases the efficacy of angiogenic gene transfer for treatment of myocardial ischemia. Hum Gene Ther. 2005 Sep; 16(9):1058-64. Gao MH, Lai NC, Hammond HK. PMID: 16149904.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    63. Why FRET? Focus on "beta-Adrenergic and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes using a FRET-based biosensor". Am J Physiol Cell Physiol. 2005 Aug; 289(2):C246-7. Hammond HK. PMID: 16002624.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    64. Myocardial gene transfer and long-term expression following intracoronary delivery of adeno-associated virus. J Gene Med. 2005 Mar; 7(3):316-24. Kaspar BK, Roth DM, Lai NC, Drumm JD, Erickson DA, McKirnan MD, Hammond HK. PMID: 15515115.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    65. Detection of dual-gene expression in arteries using an optical imaging method. J Biomed Opt. 2004 Nov-Dec; 9(6):1223-9. Chen HH, Zhan X, Kumar A, Du X, Hammond H, Cheng L, Yang X. PMID: 15568943.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    66. Nitroprusside increases gene transfer associated with intracoronary delivery of adenovirus. Hum Gene Ther. 2004 Oct; 15(10):989-94. Roth DM, Lai NC, Gao MH, Fine S, McKirnan MD, Roth DA, Hammond HK. PMID: 15585114.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    67. Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure. Circulation. 2004 Jul 20; 110(3):330-6. Lai NC, Roth DM, Gao MH, Tang T, Dalton N, Lai YY, Spellman M, Clopton P, Hammond HK. PMID: 15249510.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    68. Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1906-12. Tang T, Gao MH, Roth DM, Guo T, Hammond HK. PMID: 15242835.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    69. Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3. J Biol Chem. 2004 Sep 10; 279(37):38797-802. Gao MH, Tang T, Guo T, Sun SQ, Feramisco JR, Hammond HK. PMID: 15231818.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    70. Clinical use of intracoronary gene transfer of fibroblast growth factor for coronary artery disease. Curr Gene Ther. 2004 Jun; 4(2):225-30. Penny WF, Hammond HK. PMID: 15180588.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    71. Increased regional function and perfusion after intracoronary delivery of adenovirus encoding fibroblast growth factor 4: report of preclinical data. Hum Gene Ther. 2004 Jun; 15(6):574-87. Gao MH, Lai NC, McKirnan MD, Roth DA, Rubanyi GM, Dalton N, Roth DM, Hammond HK. PMID: 15212716.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    72. Indirect intracoronary delivery of adenovirus encoding adenylyl cyclase increases left ventricular contractile function in mice. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H172-7. Roth DM, Lai NC, Gao MH, Drumm JD, Jimenez J, Feramisco JR, Hammond HK. PMID: 15001445.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    73. Angiotensin receptor blockade improves myocardial beta-adrenergic receptor signaling in postinfarction left ventricular remodeling: a possible link between beta-adrenergic receptor kinase-1 and protein kinase C epsilon isoform. J Am Coll Cardiol. 2004 Jan 07; 43(1):125-32. Takahashi T, Anzai T, Yoshikawa T, Maekawa Y, Mahara K, Iwata M, Hammond HK, Ogawa S. PMID: 14715194.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    74. Cardiac-directed expression of adenylyl cyclase and heart rate regulation. Basic Res Cardiol. 2003 Nov; 98(6):380-7. Roth DM, Drumm JD, Bhargava V, Swaney JS, Gao MH, Hammond HK. PMID: 14556083.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    75. Adenylyl cyclase increases survival in cardiomyopathy. Circulation. 2002 Apr 23; 105(16):1989-94. Roth DM, Bayat H, Drumm JD, Gao MH, Swaney JS, Ander A, Hammond HK. PMID: 11997288.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    76. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris. Circulation. 2002 Mar 19; 105(11):1291-7. Grines CL, Watkins MW, Helmer G, Penny W, Brinker J, Marmur JD, West A, Rade JJ, Marrott P, Hammond HK, Engler RL. PMID: 11901038.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCellsCTClinical Trials
    77. Angiogenic gene therapy for heart disease: a review of animal studies and clinical trials. Cardiovasc Res. 2001 Feb 16; 49(3):561-7. Hammond HK, McKirnan MD. PMID: 11166269.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    78. Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation. 1999 Jun 22; 99(24):3099-102. Roth DM, Gao MH, Lai NC, Drumm J, Dalton N, Zhou JY, Zhu J, Entrikin D, Hammond HK. PMID: 10377071.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    79. Dissociation between regional dysfunction and beta-adrenergic receptor signaling in heart failure. Am J Physiol. 1998 10; 275(4):H1267-73. Anzai T, Lai NC, Gao M, Hammond HK. PMID: 9746475.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    80. Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):1038-43. Gao M, Ping P, Post S, Insel PA, Tang R, Hammond HK. PMID: 9448281; PMCID: PMC18663.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    81. Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist. Adv Pharmacol. 1998; 42:507-10. Hammond HK, Ping P, Insel PA. PMID: 9327951.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    82. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol. 1997 Aug; 273(2 Pt 2):H707-17. Ping P, Anzai T, Gao M, Hammond HK. PMID: 9277487.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    83. Regional deficits of myocardial blood flow and function in left ventricular pacing-induced heart failure. Circulation. 1996 Nov 01; 94(9):2260-7. Helmer GA, McKirnan MD, Shabetai R, Boss GR, Ross J, Hammond HK. PMID: 8901681.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    84. Endotoxin-induced cardiac depression is associated with decreased cardiac dihydropyridine receptors in rabbits. J Mol Cell Cardiol. 1996 Jun; 28(6):1367-71. Lew WY, Yasuda S, Yuan T, Hammond HK. PMID: 8782078.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    85. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med. 1996 May; 2(5):534-9. Giordano FJ, Ping P, McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O, Hammond HK. PMID: 8616711.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    86. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. J Clin Invest. 1995 Mar; 95(3):1271-80. Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. PMID: 7883975; PMCID: PMC441466.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    87. Force-frequency relations during heart failure in pigs. Am J Physiol. 1994 Dec; 267(6 Pt 2):H2516-22. Eising GP, Hammond HK, Helmer GA, Gilpin E, Ross J. PMID: 7810747.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    88. Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts. Am J Physiol. 1994 Nov; 267(5 Pt 2):H2079-85. Ping P, Hammond HK. PMID: 7977840.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    89. Effects of dobutamine and arbutamine on regional myocardial function in a porcine model of myocardial ischemia. J Am Coll Cardiol. 1994 Feb; 23(2):475-82. Hammond HK, McKirnan MD. PMID: 8294703.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    90. Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia. J Clin Invest. 1993 Dec; 92(6):2644-52. Hammond HK, Roth DA, McKirnan MD, Ping P. PMID: 8254020; PMCID: PMC288461.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    91. Downregulation of cardiac guanosine 5'-triphosphate-binding proteins in right atrium and left ventricle in pacing-induced congestive heart failure. J Clin Invest. 1993 Mar; 91(3):939-49. Roth DA, Urasawa K, Helmer GA, Hammond HK. PMID: 8383705; PMCID: PMC288046.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    92. Heart size and maximal cardiac output are limited by the pericardium. Am J Physiol. 1992 Dec; 263(6 Pt 2):H1675-81. Hammond HK, White FC, Bhargava V, Shabetai R. PMID: 1481894.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    93. The role of the pericardium in conditioning the effects of physical training. Chest. 1992 May; 101(5 Suppl):326S-329S. Shabetai R, Hammond HK, Lai C. PMID: 1576859.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    94. Myocardial adrenergic denervation supersensitivity depends on a postreceptor mechanism not linked with increased cAMP production. Circulation. 1992 Feb; 85(2):666-79. Hammond HK, Roth DA, Ford CE, Stamnas GW, Ziegler MG, Ennis C. PMID: 1310452.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    95. Myocardial characteristics of thyroxine stimulated hypertrophy. A structural and functional study. Basic Res Cardiol. 1989 Jul-Aug; 84(4):345-58. Breisch EA, White FC, Hammond HK, Flynn S, Bloor CM. PMID: 2530972.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    96. Noncoordinate regulation of cardiac Gs protein and beta-adrenergic receptors by a physiological stimulus, chronic dynamic exercise. J Clin Invest. 1988 Dec; 82(6):2168-71. Hammond HK, Ransnas LA, Insel PA. PMID: 2848869; PMCID: PMC442802.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
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