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    Stephen Adams

    TitleProject Scientist
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0647
    CA La Jolla 92093
    Phone858-534-5268
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      NEW PROBE AND METHODS FOR CORRELATED LM AND EM
      NIH/NIGMS R01GM086197Sep 30, 2008 - Apr 30, 2021
      Role: Co-Principal Investigator
      DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONS
      NIH/NINDS R01NS027177Apr 1, 1989 - Dec 31, 2017
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Adams S, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BN, Ellisman MH, Tsien RY. Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species. Cell Chem Biol. 2016 Oct 31. PMID: 27818300.
        View in: PubMed
      2. Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams S, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY. Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proc Natl Acad Sci U S A. 2016 Oct 20. PMID: 27791138.
        View in: PubMed
      3. Adams S. Roger Y. Tsien (1952-2016). Angew Chem Int Ed Engl. 2016 Oct 12. PMID: 27730715.
        View in: PubMed
      4. Adams S, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ. Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nat Commun. 2016 Oct 04; 7:13019. PMID: 27698471.
        View in: PubMed
      5. Ngo JT, Adams S, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nat Chem Biol. 2016 Jun; 12(6):459-65. PMID: 27110681.
        View in: PubMed
      6. Kislukhin AA, Xu H, Adams S, Narsinh KH, Tsien RY, Ahrens ET. Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging. Nat Mater. 2016 Jun; 15(6):662-8. PMID: 26974409.
        View in: PubMed
      7. Griffin BA, Adams S, Tsien RY. How FlAsH Got Its Sparkle: Historical Recollections of the Biarsenical-Tetracysteine Tag. Methods Mol Biol. 2015; 1266:1-6. PMID: 25560064.
        View in: PubMed
      8. Waadt R, Hitomi K, Nishimura N, Hitomi C, Adams S, Getzoff ED, Schroeder JI. FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis. Elife. 2014; 3:e01739. PMID: 24737861.
        View in: PubMed
      9. Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams S, Steinbach P, Nashi N, Nguyen QT, Tsien RY. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angew Chem Int Ed Engl. 2013 Jan 2; 52(1):325-30. PMID: 23080482.
        View in: PubMed
      10. Hoffmann C, Gaietta G, Zürn A, Adams S, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nat Protoc. 2010 Sep; 5(10):1666-77. PMID: 20885379.
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      11. Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams S, Gross LA, Ma W, Alber T, Tsien RY. Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem Biol. 2009 Nov 25; 16(11):1169-79. PMID: 19942140.
        View in: PubMed
      12. Madani F, Lind J, Damberg P, Adams S, Tsien RY, Gräslund AO. Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy. J Am Chem Soc. 2009 Apr 8; 131(13):4613-5. PMID: 19281235.
        View in: PubMed
      13. Adams S, Tsien RY. Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Nat Protoc. 2008; 3(9):1527-34. PMID: 18772880.
        View in: PubMed
      14. Tour O, Adams S, Kerr RA, Meijer RM, Sejnowski TJ, Tsien RW, Tsien RY. Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator. Nat Chem Biol. 2007 Jul; 3(7):423-31. PMID: 17572670.
        View in: PubMed
      15. Gaietta GM, Giepmans BN, Deerinck TJ, Smith WB, Ngan L, Llopis J, Adams S, Tsien RY, Ellisman MH. Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17777-82. PMID: 17101980.
        View in: PubMed
      16. Giepmans BN, Adams S, Ellisman MH, Tsien RY. The fluorescent toolbox for assessing protein location and function. Science. 2006 Apr 14; 312(5771):217-24. PMID: 16614209.
        View in: PubMed
      17. Sun M, Oakes JL, Ananthanarayanan SK, Hawley KH, Tsien RY, Adams S, Yengo CM. Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer. J Biol Chem. 2006 Mar 3; 281(9):5711-7. PMID: 16377637.
        View in: PubMed
      18. Martin BR, Giepmans BN, Adams S, Tsien RY. Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nat Biotechnol. 2005 Oct; 23(10):1308-14. PMID: 16155565.
        View in: PubMed
      19. Hoffmann C, Gaietta G, Bünemann M, Adams S, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat Methods. 2005 Mar; 2(3):171-6. PMID: 15782185.
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      20. Ju W, Morishita W, Tsui J, Gaietta G, Deerinck TJ, Adams S, Garner CC, Tsien RY, Ellisman MH, Malenka RC. Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors. Nat Neurosci. 2004 Mar; 7(3):244-53. PMID: 14770185.
        View in: PubMed
      21. Babendure JR, Adams S, Tsien RY. Aptamers switch on fluorescence of triphenylmethane dyes. J Am Chem Soc. 2003 Dec 3; 125(48):14716-7. PMID: 14640641.
        View in: PubMed
      22. Tour O, Meijer RM, Zacharias DA, Adams S, Tsien RY. Genetically targeted chromophore-assisted light inactivation. Nat Biotechnol. 2003 Dec; 21(12):1505-8. PMID: 14625562.
        View in: PubMed
      23. Sosinsky GE, Gaietta GM, Hand G, Deerinck TJ, Han A, Mackey M, Adams S, Bouwer J, Tsien RY, Ellisman MH. Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics. Cell Commun Adhes. 2003 Jul-Dec; 10(4-6):181-6. PMID: 14681013.
        View in: PubMed
      24. Adams S, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. J Am Chem Soc. 2002 May 29; 124(21):6063-76. PMID: 12022841.
        View in: PubMed
      25. Gaietta G, Deerinck TJ, Adams S, Bouwer J, Tour O, Laird DW, Sosinsky GE, Tsien RY, Ellisman MH. Multicolor and electron microscopic imaging of connexin trafficking. Science. 2002 Apr 19; 296(5567):503-7. PMID: 11964472.
        View in: PubMed
      26. Kapahi P, Takahashi T, Natoli G, Adams S, Chen Y, Tsien RY, Karin M. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17; 275(46):36062-6. PMID: 10967126.
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      27. Cacciatore TW, Brodfuehrer PD, Gonzalez JE, Jiang T, Adams S, Tsien RY, Kristan WB, Kleinfeld D. Identification of neural circuits by imaging coherent electrical activity with FRET-based dyes. Neuron. 1999 Jul; 23(3):449-59. PMID: 10433258.
        View in: PubMed
      28. Griffin BA, Adams S, Tsien RY. Specific covalent labeling of recombinant protein molecules inside live cells. Science. 1998 Jul 10; 281(5374):269-72. PMID: 9657724.
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      29. Adams S, Lev-Ram V, Tsien RY. A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based chelators. Chem Biol. 1997 Nov; 4(11):867-78. PMID: 9384535.
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      30. Hempel CM, Vincent P, Adams S, Tsien RY, Selverston AI. Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuitm. Nature. 1996 Nov 14; 384(6605):166-9. PMID: 8906791.
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      31. Cubitt AB, Heim R, Adams S, Boyd AE, Gross LA, Tsien RY. Understanding, improving and using green fluorescent proteins. Trends Biochem Sci. 1995 Nov; 20(11):448-55. PMID: 8578587.
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      32. Wen W, Harootunian AT, Adams S, Feramisco J, Tsien RY, Meinkoth JL, Taylor SS. Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. J Biol Chem. 1994 Dec 23; 269(51):32214-20. PMID: 7798221.
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      33. Harootunian AT, Adams S, Wen W, Meinkoth JL, Taylor SS, Tsien RY. Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion. Mol Biol Cell. 1993 Oct; 4(10):993-1002. PMID: 8298196.
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      34. Tsien RY, Bacskai BJ, Adams S. FRET for studying intracellular signalling. Trends Cell Biol. 1993 Jul; 3(7):242-5. PMID: 14731760.
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      35. Bacskai BJ, Hochner B, Mahaut-Smith M, Adams S, Kaang BK, Kandel ER, Tsien RY. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science. 1993 Apr 9; 260(5105):222-6. PMID: 7682336.
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      36. Adams S, Bacskai BJ, Hochner B, Kaang BK, Kandel ER, Mahaut-Smith M, Tsien RY. Confocal imaging of cAMP signals in Aplysia neurons. Jpn J Physiol. 1993; 43 Suppl 1:S91-3. PMID: 8271521.
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      37. Adams S, Tsien RY. Controlling cell chemistry with caged compounds. Annu Rev Physiol. 1993; 55:755-84. PMID: 8466191.
        View in: PubMed
      38. Sammak PJ, Adams S, Harootunian AT, Schliwa M, Tsien RY. Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging. J Cell Biol. 1992 Apr; 117(1):57-72. PMID: 1348251.
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      39. Adams S, Harootunian AT, Buechler YJ, Taylor SS, Tsien RY. Fluorescence ratio imaging of cyclic AMP in single cells. Nature. 1991 Feb 21; 349(6311):694-7. PMID: 1847505.
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      40. Harootunian AT, Kao JP, Paranjape S, Adams S, Potter BV, Tsien RY. Cytosolic Ca2+ oscillations in REF52 fibroblasts: Ca(2+)-stimulated IP3 production or voltage-dependent Ca2+ channels as key positive feedback elements. Cell Calcium. 1991 Feb-Mar; 12(2-3):153-64. PMID: 1647875.
        View in: PubMed
      41. Harootunian AT, Kao JP, Adams S, Tsien RY. Imaging and manipulation of cytosolic ions and messengers during cell activation. J Cell Sci Suppl. 1990; 13:1-4. PMID: 2084112.
        View in: PubMed
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