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Stephen Adams

TitleProject Scientist
InstitutionUniversity of California San Diego
DepartmentPharmacology
Address9500 Gilman Drive #0647
La Jolla CA 92093
Phone858-534-5268
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    Collapse Research 
    Collapse Research Activities and Funding
    New Probe and Methods for Correlated LM & EM
    NIH/NIGMS R01GM086197Sep 30, 2008 - Apr 30, 2021
    Role: Co-Principal Investigator
    DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONS
    NIH/NINDS R01NS027177Apr 1, 1989 - Dec 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams S, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M. Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent. Arthritis Rheumatol. 2018 Jan; 70(1):69-79. PMID: 29164814.
      View in: PubMed
    2. Lux J, Vezeridis AM, Hoyt K, Adams S, Armstrong AM, Sirsi SR, Mattrey RF. Thrombin-Activatable Microbubbles as Potential Ultrasound Contrast Agents for the Detection of Acute Thrombosis. ACS Appl Mater Interfaces. 2017 Nov 01; 9(43):37587-37596. PMID: 28994575.
      View in: PubMed
    3. Adams S, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BNG, Ellisman MH, Tsien RY. Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species. Cell Chem Biol. 2016 Nov 17; 23(11):1417-1427. PMID: 27818300.
      View in: PubMed
    4. Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams S, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY. Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proc Natl Acad Sci U S A. 2016 Oct 20. PMID: 27791138.
      View in: PubMed
    5. Adams S. Roger Y. Tsien (1952-2016). Angew Chem Int Ed Engl. 2016 Nov 02; 55(45):13926-13927. PMID: 27730715.
      View in: PubMed
    6. Adams S, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ. Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nat Commun. 2016 Oct 04; 7:13019. PMID: 27698471.
      View in: PubMed
    7. Ngo JT, Adams S, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nat Chem Biol. 2016 06; 12(6):459-65. PMID: 27110681; PMCID: PMC4871776 [Available on 10/25/16].
    8. Kislukhin AA, Xu H, Adams S, Narsinh KH, Tsien RY, Ahrens ET. Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging. Nat Mater. 2016 06; 15(6):662-8. PMID: 26974409.
      View in: PubMed
    9. Griffin BA, Adams S, Tsien RY. How FlAsH got its sparkle: historical recollections of the biarsenical-tetracysteine tag. Methods Mol Biol. 2015; 1266:1-6. PMID: 25560064.
      View in: PubMed
    10. Waadt R, Hitomi K, Nishimura N, Hitomi C, Adams S, Getzoff ED, Schroeder JI. FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis. Elife. 2014 Apr 15; 3:e01739. PMID: 24737861; PMCID: PMC3985518.
    11. Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams S, Steinbach P, Nashi N, Nguyen QT, Tsien RY. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):325-30. PMID: 23080482; PMCID: PMC3694763.
    12. Hoffmann C, Gaietta G, Zürn A, Adams S, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nat Protoc. 2010 Sep; 5(10):1666-77. PMID: 20885379; PMCID: PMC3086663.
    13. Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams S, Gross LA, Ma W, Alber T, Tsien RY. Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem Biol. 2009 Nov 25; 16(11):1169-79. PMID: 19942140; PMCID: PMC2814181.
    14. Madani F, Lind J, Damberg P, Adams S, Tsien RY, Gräslund AO. Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy. J Am Chem Soc. 2009 Apr 08; 131(13):4613-5. PMID: 19281235; PMCID: PMC2735349.
    15. Adams S, Tsien RY. Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Nat Protoc. 2008; 3(9):1527-34. PMID: 18772880; PMCID: PMC2843588.
    16. Tour O, Adams S, Kerr RA, Meijer RM, Sejnowski TJ, Tsien RW, Tsien RY. Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator. Nat Chem Biol. 2007 Jul; 3(7):423-31. PMID: 17572670; PMCID: PMC2909385.
    17. Gaietta GM, Giepmans BN, Deerinck TJ, Smith WB, Ngan L, Llopis J, Adams S, Tsien RY, Ellisman MH. Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17777-82. PMID: 17101980; PMCID: PMC1635977.
    18. Giepmans BN, Adams S, Ellisman MH, Tsien RY. The fluorescent toolbox for assessing protein location and function. Science. 2006 Apr 14; 312(5771):217-24. PMID: 16614209.
      View in: PubMed
    19. Sun M, Oakes JL, Ananthanarayanan SK, Hawley KH, Tsien RY, Adams S, Yengo CM. Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer. J Biol Chem. 2006 Mar 03; 281(9):5711-7. PMID: 16377637.
      View in: PubMed
    20. Martin BR, Giepmans BN, Adams S, Tsien RY. Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nat Biotechnol. 2005 Oct; 23(10):1308-14. PMID: 16155565.
      View in: PubMed
    21. Hoffmann C, Gaietta G, Bünemann M, Adams S, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat Methods. 2005 Mar; 2(3):171-6. PMID: 15782185.
      View in: PubMed
    22. Ju W, Morishita W, Tsui J, Gaietta G, Deerinck TJ, Adams S, Garner CC, Tsien RY, Ellisman MH, Malenka RC. Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors. Nat Neurosci. 2004 Mar; 7(3):244-53. PMID: 14770185.
      View in: PubMed
    23. Babendure JR, Adams S, Tsien RY. Aptamers switch on fluorescence of triphenylmethane dyes. J Am Chem Soc. 2003 Dec 03; 125(48):14716-7. PMID: 14640641.
      View in: PubMed
    24. Tour O, Meijer RM, Zacharias DA, Adams S, Tsien RY. Genetically targeted chromophore-assisted light inactivation. Nat Biotechnol. 2003 Dec; 21(12):1505-8. PMID: 14625562.
      View in: PubMed
    25. Sosinsky GE, Gaietta GM, Hand G, Deerinck TJ, Han A, Mackey M, Adams S, Bouwer J, Tsien RY, Ellisman MH. Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics. Cell Commun Adhes. 2003 Jul-Dec; 10(4-6):181-6. PMID: 14681013.
      View in: PubMed
    26. Adams S, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. J Am Chem Soc. 2002 May 29; 124(21):6063-76. PMID: 12022841.
      View in: PubMed
    27. Gaietta G, Deerinck TJ, Adams S, Bouwer J, Tour O, Laird DW, Sosinsky GE, Tsien RY, Ellisman MH. Multicolor and electron microscopic imaging of connexin trafficking. Science. 2002 Apr 19; 296(5567):503-7. PMID: 11964472.
      View in: PubMed
    28. Adams S, Lev-Ram V, Tsien RY. A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based chelators. Chem Biol. 1997 Nov; 4(11):867-78. PMID: 9384535.
      View in: PubMed