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Stephen Adams

Title(s)PROJ SCIENTIST-FY NON REP, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Developing new tools for high throughput analysis of microcircuits and synapse ultrastructure using tagged vesicular transporters and deep learning.
    NIH RF1MH120685Aug 1, 2019 - Jul 31, 2022
    Role: Co-Investigator
    Elucidation and therapeutic exploitation of PAK mediated radioresistance
    NIH R37CA215081Dec 18, 2017 - Nov 30, 2022
    Role: Co-Investigator
    Compositions and methods for enhanced fluorine-19 magnetic resonance imaging cell tracking
    NIH/NIBIB R01EB024015Apr 15, 2017 - Feb 28, 2021
    Role: Co-Investigator
    New Probe and Methods for Correlated LM & EM
    NIH R01GM086197Sep 30, 2008 - Apr 30, 2021
    Role: Co-Principal Investigator
    DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONS
    NIH R01NS027177Apr 1, 1989 - Dec 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Elemental mapping of labeled biological specimens at intermediate energy loss in an energy-filtered TEM acquired using a direct detection device. J Microsc. 2021 Apr 12. Ramachandra R, Mackey MR, Hu J, Peltier ST, Xuong NH, Ellisman MH, Adams SR. PMID: 33844293.
      View in: PubMed   Mentions:    Fields:    
    2. Tumor Activated Cell Penetrating Peptides to Selectively Deliver Immune Modulatory Drugs. Pharmaceutics. 2021 Mar 10; 13(3). Hingorani DV, Camargo MF, Quraishi MA, Adams SR, Advani SJ. PMID: 33801967.
      View in: PubMed   Mentions:
    3. Metallo-Fluorocarbon Nanoemulsion for Inflammatory Macrophage Detection via PET and MRI. J Nucl Med. 2020 Dec 04. Wang C, Leach BI, Lister D, Adams SR, Xu H, Hoh CK, McConville P, Zhang J, Messer K, Ahrens E. PMID: 33277399.
      View in: PubMed   Mentions:    Fields:    
    4. Aequorea's secrets revealed: New fluorescent proteins with unique properties for bioimaging and biosensing. PLoS Biol. 2020 Nov; 18(11):e3000936. Lambert GG, Depernet H, Gotthard G, Schultz DT, Navizet I, Lambert T, Adams SR, Torreblanca-Zanca A, Chu M, Bindels DS, Levesque V, Nero Moffatt J, Salih A, Royant A, Shaner NC. PMID: 33137097.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems. Cell Chem Biol. 2020 Aug 20; 27(8):1063-1072.e7. Binns TC, Ayala AX, Grimm JB, Tkachuk AN, Castillon GA, Phan S, Zhang L, Brown TA, Liu Z, Adams SR, Ellisman MH, Koyama M, Lavis LD. PMID: 32698018.
      View in: PubMed   Mentions: 1     Fields:    
    6. Paramagnetic Fluorinated Nanoemulsions for in vivo F-19 MRI. Mol Imaging Biol. 2020 06; 22(3):665-674. Rho J, Stares E, Adams SR, Lister D, Leach B, Ahrens ET. PMID: 31482414.
      View in: PubMed   Mentions:    Fields:    
    7. Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors. Biomaterials. 2020 07; 248:120032. Hingorani DV, Crisp JL, Doan MK, Camargo MF, Quraishi MA, Aguilera J, Gilardi M, Gross LA, Jiang T, Li WT, Ongkeko WM, Cohen EEW, Gutkind JS, Adams SR, Advani SJ. PMID: 32304937.
      View in: PubMed   Mentions:    Fields:    
    8. Cell penetrating peptide functionalized perfluorocarbon nanoemulsions for targeted cell labeling and enhanced fluorine-19 MRI detection. Magn Reson Med. 2020 03; 83(3):974-987. Hingorani DV, Chapelin F, Stares E, Adams SR, Okada H, Ahrens ET. PMID: 31631402.
      View in: PubMed   Mentions:    Fields:    
    9. Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability. Mol Cancer Ther. 2020 01; 19(1):157-167. Hingorani DV, Doan MK, Camargo MF, Aguilera J, Song SM, Pizzo D, Scanderbeg DJ, Cohen EEW, Lowy AM, Adams SR, Advani SJ. PMID: 31597712.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. ß-Diketonate-Iron(III) Complex: A Versatile Fluorine-19 MRI Signal Enhancement Agent. ACS Appl Bio Mater. 2019 Sep 16; 2(9):3836-3842. Wang C, Adams SR, Xu H, Zhu W, Ahrens ET. PMID: 33981964.
      View in: PubMed   Mentions:
    11. Split-miniSOG for Spatially Detecting Intracellular Protein-Protein Interactions by Correlated Light and Electron Microscopy. Cell Chem Biol. 2019 10 17; 26(10):1407-1416.e5. Boassa D, Lemieux SP, Lev-Ram V, Hu J, Xiong Q, Phan S, Mackey M, Ramachandra R, Peace RE, Adams SR, Ellisman MH, Ngo JT. PMID: 31378710.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes. ACS Nano. 2019 01 22; 13(1):143-151. Jahromi AH, Wang C, Adams SR, Zhu W, Narsinh K, Xu H, Gray DL, Tsien RY, Ahrens ET. PMID: 30525446.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Editorial Overview: Non-invasive molecular imaging: dedicated to the memory of Professor Roger Tsien. Curr Opin Chem Biol. 2018 08; 45:iv-vi. Adams S, Rao J. PMID: 30075836.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent. Arthritis Rheumatol. 2018 01; 70(1):69-79. Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M. PMID: 29164814.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    15. Thrombin-Activatable Microbubbles as Potential Ultrasound Contrast Agents for the Detection of Acute Thrombosis. ACS Appl Mater Interfaces. 2017 Nov 01; 9(43):37587-37596. Lux J, Vezeridis AM, Hoyt K, Adams SR, Armstrong AM, Sirsi SR, Mattrey RF. PMID: 28994575.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    16. Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species. Cell Chem Biol. 2016 Nov 17; 23(11):1417-1427. Adams SR, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BNG, Ellisman MH, Tsien RY. PMID: 27818300.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    17. Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):12774-12779. Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY. PMID: 27791138.
      View in: PubMed   Mentions: 6     Fields:    
    18. Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nat Commun. 2016 10 04; 7:13019. Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ. PMID: 27698471.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    19. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nat Chem Biol. 2016 06; 12(6):459-65. Ngo JT, Adams SR, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY. PMID: 27110681.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging. Nat Mater. 2016 06; 15(6):662-8. Kislukhin AA, Xu H, Adams SR, Narsinh KH, Tsien RY, Ahrens ET. PMID: 26974409.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    21. How FlAsH got its sparkle: historical recollections of the biarsenical-tetracysteine tag. Methods Mol Biol. 2015; 1266:1-6. Griffin BA, Adams SR, Tsien RY. PMID: 25560064.
      View in: PubMed   Mentions: 2     Fields:    
    22. FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis. Elife. 2014 Apr 15; 3:e01739. Waadt R, Hitomi K, Nishimura N, Hitomi C, Adams SR, Getzoff ED, Schroeder JI. PMID: 24737861.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCellsPHPublic Health
    23. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):325-30. Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams SR, Steinbach P, Nashi N, Nguyen QT, Tsien RY. PMID: 23080482.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    24. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nat Protoc. 2010 Sep; 5(10):1666-77. Hoffmann C, Gaietta G, Zürn A, Adams SR, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. PMID: 20885379.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    25. Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem Biol. 2009 Nov 25; 16(11):1169-79. Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams SR, Gross LA, Ma W, Alber T, Tsien RY. PMID: 19942140.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    26. Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy. J Am Chem Soc. 2009 Apr 08; 131(13):4613-5. Madani F, Lind J, Damberg P, Adams SR, Tsien RY, Gräslund AO. PMID: 19281235.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    27. Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Nat Protoc. 2008; 3(9):1527-34. Adams SR, Tsien RY. PMID: 18772880.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    28. Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator. Nat Chem Biol. 2007 Jul; 3(7):423-31. Tour O, Adams SR, Kerr RA, Meijer RM, Sejnowski TJ, Tsien RW, Tsien RY. PMID: 17572670.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    29. Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17777-82. Gaietta GM, Giepmans BN, Deerinck TJ, Smith WB, Ngan L, Llopis J, Adams SR, Tsien RY, Ellisman MH. PMID: 17101980.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    30. The fluorescent toolbox for assessing protein location and function. Science. 2006 Apr 14; 312(5771):217-24. Giepmans BN, Adams SR, Ellisman MH, Tsien RY. PMID: 16614209.
      View in: PubMed   Mentions: 650     Fields:    Translation:Cells
    31. Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer. J Biol Chem. 2006 Mar 03; 281(9):5711-7. Sun M, Oakes JL, Ananthanarayanan SK, Hawley KH, Tsien RY, Adams SR, Yengo CM. PMID: 16377637.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    32. Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nat Biotechnol. 2005 Oct; 23(10):1308-14. Martin BR, Giepmans BN, Adams SR, Tsien RY. PMID: 16155565.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansCells
    33. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat Methods. 2005 Mar; 2(3):171-6. Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. PMID: 15782185.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    34. Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors. Nat Neurosci. 2004 Mar; 7(3):244-53. Ju W, Morishita W, Tsui J, Gaietta G, Deerinck TJ, Adams SR, Garner CC, Tsien RY, Ellisman MH, Malenka RC. PMID: 14770185.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    35. Aptamers switch on fluorescence of triphenylmethane dyes. J Am Chem Soc. 2003 Dec 03; 125(48):14716-7. Babendure JR, Adams SR, Tsien RY. PMID: 14640641.
      View in: PubMed   Mentions: 95     Fields:    
    36. Genetically targeted chromophore-assisted light inactivation. Nat Biotechnol. 2003 Dec; 21(12):1505-8. Tour O, Meijer RM, Zacharias DA, Adams SR, Tsien RY. PMID: 14625562.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    37. Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics. Cell Commun Adhes. 2003 Jul-Dec; 10(4-6):181-6. Sosinsky GE, Gaietta GM, Hand G, Deerinck TJ, Han A, Mackey M, Adams SR, Bouwer J, Tsien RY, Ellisman MH. PMID: 14681013.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    38. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. J Am Chem Soc. 2002 May 29; 124(21):6063-76. Adams SR, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. PMID: 12022841.
      View in: PubMed   Mentions: 232     Fields:    Translation:HumansCells
    39. Multicolor and electron microscopic imaging of connexin trafficking. Science. 2002 Apr 19; 296(5567):503-7. Gaietta G, Deerinck TJ, Adams SR, Bouwer J, Tour O, Laird DW, Sosinsky GE, Tsien RY, Ellisman MH. PMID: 11964472.
      View in: PubMed   Mentions: 284     Fields:    Translation:HumansAnimalsCells
    40. A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based chelators. Chem Biol. 1997 Nov; 4(11):867-78. Adams SR, Lev-Ram V, Tsien RY. PMID: 9384535.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
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