Robert Ross

TitleProfessor In Residence
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0613C
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Costamere Structure, Membrane Stability and Integrin Trafficking in the Normal and Diseased Heart
    VA I01BX003260Apr 1, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Cardiac Myocyte Form and Function: Role of Talin and Kindlin
    NIH/NHLBI R01HL127806Jul 1, 2015 - Jun 30, 2019
    Role: Principal Investigator
    Diversity in Research and Medicine
    NIH/NHLBI R25HL120892Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Integrins and Caveolin Proteins in Cardiac Hypertrophy and Failure
    NIH/NHLBI R01HL115933Sep 1, 2013 - May 31, 2017
    Role: Principal Investigator
    Replacement of Small Animal Echocardiographic Instrumentation
    NIH S10OD010417Jun 5, 2012 - Jun 4, 2013
    Role: Principal Investigator
    Beta-1 Integrin and Caveolin-3 in Cardiac Mechanotransduction
    VA I01BX001704Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Cardiomyocyte mechanotransduction through the integrin complex
    NIH/NHLBI R01HL103566Jul 15, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Integrin Function in Cardiac Remodeling
    NIH/NHLBI R01HL088390Apr 1, 2008 - Mar 31, 2012
    Role: Principal Investigator
    MSTP Summer Undergraduate Research Fellowship (SURF)
    NIH/NHLBI R25HL084692Aug 21, 2006 - Jul 31, 2013
    Role: Principal Investigator
    Vinculin and Metavinculin Function in the Myocardium
    NIH/NHLBI R01HL073393Apr 18, 2003 - Mar 31, 2007
    Role: Principal Investigator
    BI Integrins Signaling During Cardiogenesis &Growth
    NIH/NHLBI R01HL057872Aug 1, 1996 - Jul 31, 2006
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH/NHLBI P01HL046345Feb 1, 1992 - Jun 30, 2014
    Role: Co-Investigator
    Training In Cardiovascular Physiology & Pharmacology
    NIH/NHLBI T32HL007444Jul 1, 1979 - Jun 30, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Manso AM, Okada H, Sakamoto FM, Moreno E, Monkley SJ, Li R, Critchley DR, Ross R. Loss of mouse cardiomyocyte talin-1 and talin-2 leads to ß-1 integrin reduction, costameric instability, and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2017 Jul 25; 114(30):E6250-E6259. PMID: 28698364.
      View in: PubMed
    2. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross R, Hammond HK, Patel HH, Roth DM. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. PMID: 28498861.
      View in: PubMed
    3. Ma X, Chen C, Veevers J, Zhou X, Ross R, Feng W, Chen J. CRISPR/Cas9-mediated gene manipulation to create single-amino-acid-substituted and floxed mice with a cloning-free method. Sci Rep. 2017 Feb 08; 7:42244. PMID: 28176880.
      View in: PubMed
    4. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross R, Chen-Izu Y. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. PMID: 27500929.
      View in: PubMed
    5. Zhang Z, Mu Y, Veevers J, Peter AK, Manso AM, Bradford WH, Dalton ND, Peterson KL, Knowlton KU, Ross R, Zhou X, Chen J. Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail. 2016 Aug; 9(8). PMID: 27502369; PMCID: PMC4979611 [Available on 08/01/17].
    6. Hammond HK, Penny WF, Traverse JH, Henry TD, Watkins MW, Yancy CW, Sweis RN, Adler ED, Patel AN, Murray DR, Ross R, Bhargava V, Maisel A, Barnard DD, Lai NC, Dalton ND, Lee ML, Narayan SM, Blanchard DG, Gao MH. Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial. JAMA Cardiol. 2016 05 01; 1(2):163-71. PMID: 27437887.
      View in: PubMed
    7. Chen C, Li R, Ross R, Manso AM. Integrins and integrin-related proteins in cardiac fibrosis. J Mol Cell Cardiol. 2016 04; 93:162-74. PMID: 26562414.
      View in: PubMed
    8. Israeli-Rosenberg S, Chen C, Li R, Deussen DN, Niesman IR, Okada H, Patel HH, Roth DM, Ross R. Caveolin modulates integrin function and mechanical activation in the cardiomyocyte. FASEB J. 2015 Feb; 29(2):374-84. PMID: 25366344; PMCID: PMC4314226.
    9. Israeli-Rosenberg S, Manso AM, Okada H, Ross R. Integrins and integrin-associated proteins in the cardiac myocyte. Circ Res. 2014 Jan 31; 114(3):572-586. PMID: 24481847; PMCID: PMC3975046.
    10. Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross R. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014 Mar 01; 127(Pt 5):1104-16. PMID: 24413171; PMCID: PMC3937777.
    11. Nishimura M, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan H, Cammarato A, Ross R, Engler AJ, Bodmer R, Hansen M, Ocorr K. A dual role for integrin-linked kinase and ß1-integrin in modulating cardiac aging. Aging Cell. 2014 Jun; 13(3):431-40. PMID: 24400780; PMCID: PMC4032615.
    12. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross R. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324; PMCID: PMC3784521.
    13. Thievessen I, Thompson PM, Berlemont S, Plevock KM, Plotnikov SV, Zemljic-Harpf A, Ross R, Davidson MW, Danuser G, Campbell SL, Waterman CM. Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol. 2013 Jul 08; 202(1):163-77. PMID: 23836933; PMCID: PMC3704983.
    14. Winkler U, Hirrlinger PG, Sestu M, Wilhelm F, Besser S, Zemljic-Harpf AE, Ross R, Bornschein G, Krügel U, Ziegler WH, Hirrlinger J. Deletion of the cell adhesion adaptor protein vinculin disturbs the localization of GFAP in Bergmann glial cells. Glia. 2013 Jul; 61(7):1067-83. PMID: 23595642.
      View in: PubMed
    15. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross R, Frank LR, McCulloch AD, Omens JH. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 02; 104(7):1623-33. PMID: 23561539; PMCID: PMC3617425.
    16. Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross R. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 08; 288(6):4252-64. PMID: 23266827; PMCID: PMC3567677.
    17. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross R, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. PMID: 22859372; PMCID: PMC4050367.
    18. Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross R, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ. New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Eur J Cell Biol. 2012 Mar; 91(3):180-91. PMID: 22306379; PMCID: PMC3629562.
    19. Li R, Wu Y, Manso AM, Gu Y, Liao P, Israeli S, Yajima T, Nguyen U, Huang MS, Dalton ND, Peterson KL, Ross R. ß1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses. Am J Pathol. 2012 Mar; 180(3):952-62. PMID: 22248583; PMCID: PMC3349893.
    20. Liu J, Milner DJ, Boppart MD, Ross R, Kaufman SJ. ß1D chain increases a7ß1 integrin and laminin and protects against sarcolemmal damage in mdx mice. Hum Mol Genet. 2012 Apr 01; 21(7):1592-603. PMID: 22180459; PMCID: PMC3298282.
    21. Peter AK, Cheng H, Ross R, Knowlton KU, Chen J. The costamere bridges sarcomeres to the sarcolemma in striated muscle. Prog Pediatr Cardiol. 2011 May; 31(2):83-88. PMID: 24039381.
      View in: PubMed
    22. Chuang JS, Zemljic-Harpf A, Ross R, Frank LR, McCulloch AD, Omens JH. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. PMID: 20981782; PMCID: PMC3272305.
    23. Zemljic-Harpf A, Manso AM, Ross R. Vinculin and talin: focus on the myocardium. J Investig Med. 2009 Dec; 57(8):849-55. PMID: 19952892; PMCID: PMC2810504.
    24. Manso AM, Kang SM, Ross R. Integrins, focal adhesions, and cardiac fibroblasts. J Investig Med. 2009 Dec; 57(8):856-60. PMID: 19952893; PMCID: PMC2810503.
    25. Sheikh F, Ross R, Chen J. Cell-cell connection to cardiac disease. Trends Cardiovasc Med. 2009 Aug; 19(6):182-90. PMID: 20211433; PMCID: PMC3601820.
    26. Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush KT, Vera DR, Ross R, Nigam SK. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F210-7. PMID: 19439520; PMCID: PMC2711709.
    27. Ieda M, Tsuchihashi T, Ivey KN, Ross R, Hong TT, Shaw RM, Srivastava D. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb; 16(2):233-44. PMID: 19217425; PMCID: PMC2664087.
    28. Manso AM, Kang SM, Plotnikov SV, Thievessen I, Oh J, Beggs HE, Ross R. Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H627-38. PMID: 19136609; PMCID: PMC2660223.
    29. Caglayan E, Stauber B, Collins AR, Lyon CJ, Yin F, Liu J, Rosenkranz S, Erdmann E, Peterson LE, Ross R, Tangirala RK, Hsueh WA. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Diabetes. 2008 Sep; 57(9):2470-9. PMID: 18511847; PMCID: PMC2518499.
    30. Elsherif L, Huang MS, Shai SY, Yang Y, Li RY, Chun J, Mekany MA, Chu AL, Kaufman SJ, Ross R. Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. Circ Res. 2008 May 09; 102(9):1109-17. PMID: 18340010.
      View in: PubMed
    31. Ross R, Chen J. Models that Buzz, Squeak, Ribbit and Oink: Using a Variety of Species to Study Cardiovascular Disease. Drug Discov Today Dis Models. 2008; 5(3):113-115. PMID: 19802370.
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    32. Lei L, Liu D, Huang Y, Jovin I, Shai SY, Kyriakides T, Ross R, Giordano FJ. Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling. Mol Cell Biol. 2008 Jan; 28(2):794-802. PMID: 17984225; PMCID: PMC2223431.
    33. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross R. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov; 27(21):7522-37. PMID: 17785437; PMCID: PMC2169049.
    34. Roos KP, Jordan MC, Fishbein MC, Ritter MR, Friedlander M, Chang HC, Rahgozar P, Han T, Garcia AJ, Maclellan WR, Ross R, Philipson KD. Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger. J Card Fail. 2007 May; 13(4):318-29. PMID: 17517353; PMCID: PMC2017112.
    35. Menon B, Johnson JN, Ross R, Singh M, Singh K. Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins. J Mol Cell Cardiol. 2007 Mar; 42(3):653-61. PMID: 17292911; PMCID: PMC1894917.
    36. Menon B, Krishnamurthy P, Kaverina E, Johnson JN, Ross R, Singh M, Singh K. Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway. Basic Res Cardiol. 2006 Nov; 101(6):485-93. PMID: 16783488.
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    37. Oh YS, Jong AY, Kim DT, Li H, Wang C, Zemljic-Harpf A, Ross R, Fishbein MC, Chen PS, Chen LS. Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm. 2006 Jun; 3(6):728-36. PMID: 16731479.
      View in: PubMed
    38. Manso AM, Elsherif L, Kang SM, Ross R. Integrins, membrane-type matrix metalloproteinases and ADAMs: potential implications for cardiac remodeling. Cardiovasc Res. 2006 Feb 15; 69(3):574-84. PMID: 16253214.
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    39. Menon B, Singh M, Ross R, Johnson JN, Singh K. beta-Adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of beta1 integrin signaling and mitochondrial pathway. Am J Physiol Cell Physiol. 2006 Jan; 290(1):C254-61. PMID: 16148033.
      View in: PubMed
    40. Zemljic-Harpf AE, Ponrartana S, Avalos RT, Jordan MC, Roos KP, Dalton ND, Phan VQ, Adamson ED, Ross R. Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol. 2004 Sep; 165(3):1033-44. PMID: 15331426; PMCID: PMC1618594.
    41. Ross R. Molecular and mechanical synergy: cross-talk between integrins and growth factor receptors. Cardiovasc Res. 2004 Aug 15; 63(3):381-90. PMID: 15276463.
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    42. Henderson SA, Goldhaber JI, So JM, Han T, Motter C, Ngo A, Chantawansri C, Ritter MR, Friedlander M, Nicoll DA, Frank JS, Jordan MC, Roos KP, Ross R, Philipson KD. Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circ Res. 2004 Sep 17; 95(6):604-11. PMID: 15308581.
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    43. Cheng Q, Ross R, Walsh KB. Overexpression of the integrin beta(1A) subunit and the beta(1A) cytoplasmic domain modifies the beta-adrenergic regulation of the cardiac L-type Ca(2+)current. J Mol Cell Cardiol. 2004 Jun; 36(6):809-19. PMID: 15158122.
      View in: PubMed
    44. Collins AR, Schnee J, Wang W, Kim S, Fishbein MC, Bruemmer D, Law RE, Nicholas S, Ross R, Hsueh WA. Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart. J Am Coll Cardiol. 2004 May 05; 43(9):1698-705. PMID: 15120833.
      View in: PubMed
    45. Ross R. Cardiac remodeling: is 8 the heart's lucky number? J Mol Cell Cardiol. 2004 Mar; 36(3):323-6. PMID: 15010269.
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    46. Inubushi M, Jordan MC, Roos KP, Ross R, Chatziioannou AF, Stout DB, Dahlbom M, Schelbert HR. Nitrogen-13 ammonia cardiac positron emission tomography in mice: effects of clonidine-induced changes in cardiac work on myocardial perfusion. Eur J Nucl Med Mol Imaging. 2004 Jan; 31(1):110-6. PMID: 14551749.
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    47. Schelbert HR, Inubushi M, Ross R. PET imaging in small animals. J Nucl Cardiol. 2003 Sep-Oct; 10(5):513-20. PMID: 14569245.
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    48. Reuter H, Henderson SA, Han T, Mottino GA, Frank JS, Ross R, Goldhaber JI, Philipson KD. Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Cell Calcium. 2003 Jul; 34(1):19-26. PMID: 12767889.
      View in: PubMed
    49. Willey CD, Balasubramanian S, Rodríguez Rosas MC, Ross R, Kuppuswamy D. Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src. J Mol Cell Cardiol. 2003 Jun; 35(6):671-83. PMID: 12788385.
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    50. Ross R. The extracellular connections: the role of integrins in myocardial remodeling. J Card Fail. 2002 Dec; 8(6 Suppl):S326-31. PMID: 12555140.
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    51. Babbitt CJ, Shai SY, Harpf AE, Pham CG, Ross R. Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Histochem Cell Biol. 2002 Dec; 118(6):431-9. PMID: 12483308.
      View in: PubMed
    52. Jordan MC, Quednau BD, Roos KP, Ross R, Philipson KD, Nicholas SB. Cyclosporin A regulates sodium-calcium exchanger (NCX1) gene expression in vitro and cardiac hypertrophy in NCX1 transgenic mice. Ann N Y Acad Sci. 2002 Nov; 976:259-67. PMID: 12502568.
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    53. Reuter H, Henderson SA, Han T, Matsuda T, Baba A, Ross R, Goldhaber JI, Philipson KD. Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors. Circ Res. 2002 Jul 26; 91(2):90-2. PMID: 12142340.
      View in: PubMed
    54. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross R. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002 Mar 08; 90(4):458-64. PMID: 11884376.
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    55. Reuter H, Henderson SA, Han T, Ross R, Goldhaber JI, Philipson KD. The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002 Feb 22; 90(3):305-8. PMID: 11861419.
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    56. Shai SY, Harpf AE, Ross R. Integrins and the myocardium. Genet Eng (N Y). 2002; 24:87-105. PMID: 12416302.
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