Robert Ross

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-2195-8982 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Columbia University, New York, NYA.B.05/1979Psychology / Liberal Arts
    University of Southern California, Los Angeles,M.D.05/1983Medicine
    UCSD- Rady School of Management, La Jolla, CAM.B.A.06/2020Management / Leadership

    Collapse Overview 
    Collapse Overview
    Research focuses globally on the molecular basis of heart disease, specifically hypertrophy, heart failure and conduction system disease. We currently have interests in studying cell-cell, cell-matrix and mitochondrial proteins. A portion of the lab work also studies these proteins in skeletal muscle pathologies.

    Collapse Research 
    Collapse Research Activities and Funding
    Perm1 in skeletal muscle dysfunction induced by disuse and heart failure
    NIH I01BX004897Apr 1, 2020 - Mar 31, 2024
    Role: Principal Investigator
    PERM in Cardiac Function
    NIH R01HL151239Jan 1, 2020 - Dec 31, 2023
    Role: Principal Investigator
    UCSD PRIDE Faculty Development Program in Cardiovascular Sciences
    NIH R25HL145817Feb 8, 2019 - Jan 31, 2024
    Role: Co-Principal Investigator
    Costamere Structure, Membrane Stability and Integrin Trafficking in the Normal and Diseased Heart
    NIH I01BX003260Apr 1, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Cardiac Myocyte Form and Function: Role of Talin and Kindlin
    NIH R01HL127806Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Diversity in Research and Medicine
    NIH R25HL120892Apr 1, 2014 - Mar 31, 2020
    Role: Principal Investigator
    Integrins and Caveolin Proteins in Cardiac Hypertrophy and Failure
    NIH R01HL115933Sep 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Replacement of Small Animal Echocardiographic Instrumentation
    NIH S10OD010417Jun 5, 2012 - Jun 4, 2013
    Role: Principal Investigator
    Beta-1 Integrin and Caveolin-3 in Cardiac Mechanotransduction
    NIH I01BX001704Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Cardiomyocyte mechanotransduction through the integrin complex
    NIH R01HL103566Jul 15, 2010 - Apr 30, 2016
    Role: Principal Investigator
    Integrin Function in Cardiac Remodeling
    NIH R01HL088390Apr 1, 2008 - Mar 31, 2012
    Role: Principal Investigator
    MSTP Summer Undergraduate Research Fellowship (SURF)
    NIH R25HL084692Aug 21, 2006 - Jul 31, 2013
    Role: Principal Investigator
    Vinculin and Metavinculin Function in the Myocardium
    NIH R01HL073393Apr 18, 2003 - Mar 31, 2007
    Role: Principal Investigator
    BI Integrins Signaling During Cardiogenesis &Growth
    NIH R01HL057872Aug 1, 1996 - Jul 31, 2006
    Role: Principal Investigator
    Training in Cardiovascular Physiology and Pharmacology
    NIH T32HL007444Jul 1, 1979 - Jun 30, 2023
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH P01HL046345Jun 30, 2014
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Perm1 Protects the Heart From Pressure Overload-Induced Dysfunction by Promoting Oxidative Metabolism. Circulation. 2023 03 14; 147(11):916-919. Tachibana S, Yu NK, Li R, Fernandez-Costa C, Liang A, Choi J, Jung D, Xiao C, Kralli A, Yates JR, Ross RS, Cho Y. PMID: 36913499; PMCID: PMC10018424.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    2. Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice. J Biol Chem. 2021 07; 297(1):100825. Cho Y, Tachibana S, Lam K, Arita Y, Khosrowjerdi S, Zhang O, Liang A, Li R, Andreyev A, Murphy AN, Ross RS. PMID: 34029594; PMCID: PMC8214196.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    3. Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells. Dev Cell. 2021 03 22; 56(6):761-780.e7. Biswas R, Banerjee A, Lembo S, Zhao Z, Lakshmanan V, Lim R, Le S, Nakasaki M, Kutyavin V, Wright G, Palakodeti D, Ross RS, Jamora C, Vasioukhin V, Jie Y, Raghavan S. PMID: 33725480.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. Integrating Integrins: A New Way to Increase Our COVID-19 Armamentarium? JACC Basic Transl Sci. 2021 Jan; 6(1):9-11. Ross RS. PMID: 33521397; PMCID: PMC7834098.
      View in: PubMed   Mentions: 1  
    5. Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function. Circ Res. 2020 07 03; 127(2):284-297. Zhang J, Vincent KP, Peter AK, Klos M, Cheng H, Huang SM, Towne JK, Ferng D, Gu Y, Dalton ND, Chan Y, Li R, Peterson KL, Chen J, McCulloch AD, Knowlton KU, Ross RS. PMID: 32345129; PMCID: PMC7571547.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking. Sci Rep. 2020 02 07; 10(1):2142. Wilson ZS, Witt H, Hazlett L, Harman M, Neumann BM, Whitman A, Patel M, Ross RS, Franck C, Reichner JS, Lefort CT. PMID: 32034208; PMCID: PMC7005776.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    7. Vinculins interaction with talin is essential for mammary epithelial differentiation. Sci Rep. 2019 12 05; 9(1):18400. Wang P, Wu J, Wood A, Jones M, Pedley R, Li W, Ross RS, Ballestrem C, Gilmore AP, Streuli CH. PMID: 31804547; PMCID: PMC6895056.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Talin and Kindlin as Integrin-Activating Proteins: Focus on the Heart. Pediatr Cardiol. 2019 Oct; 40(7):1401-1409. Chen C, Manso AM, Ross RS. PMID: 31367953; PMCID: PMC7590617.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    9. Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture. Circulation. 2019 03 19; 139(12):1554-1556. Zhang Z, Mu Y, Zhang J, Zhou Y, Cattaneo P, Veevers J, Peter AK, Manso AM, Knowlton KU, Zhou X, Evans SM, Ross RS, Chen J. PMID: 30883226; PMCID: PMC6424132.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    10. Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training. Mol Metab. 2019 05; 23:88-97. Cho Y, Tachibana S, Hazen BC, Moresco JJ, Yates JR, Kok B, Saez E, Ross RS, Russell AP, Kralli A. PMID: 30862473; PMCID: PMC6480336.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer. J Vis Exp. 2019 02 13; (144). Tachibana S, Chen C, Zhang OR, Schurr SV, Hill C, Li R, Manso AM, Zhang J, Andreyev A, Murphy AN, Ross RS, Cho Y. PMID: 30829322; PMCID: PMC7605210.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Combinatorial interactions of genetic variants in human cardiomyopathy. Nat Biomed Eng. 2019 02; 3(2):147-157. Deacon DC, Happe CL, Chen C, Tedeschi N, Manso AM, Li T, Dalton ND, Peng Q, Farah EN, Gu Y, Tenerelli KP, Tran VD, Chen J, Peterson KL, Schork NJ, Adler ED, Engler AJ, Ross RS, Chi NC. PMID: 30923642; PMCID: PMC6433174.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    13. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nat Commun. 2019 01 08; 10(1):76. Schips TG, Vanhoutte D, Vo A, Correll RN, Brody MJ, Khalil H, Karch J, Tjondrokoesoemo A, Sargent MA, Maillet M, Ross RS, Molkentin JD. PMID: 30622267; PMCID: PMC6325143.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    14. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018 11 27; 138(22):2530-2544. Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. PMID: 30571348; PMCID: PMC6309790.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    15. A mini review: Proteomics approaches to understand disused vs. exercised human skeletal muscle. Physiol Genomics. 2018 09 01; 50(9):746-757. Cho Y, Ross RS. PMID: 29958080; PMCID: PMC6172614.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Vinculin is required to maintain glomerular barrier integrity. Kidney Int. 2018 03; 93(3):643-655. Lausecker F, Tian X, Inoue K, Wang Z, Pedigo CE, Hassan H, Liu C, Zimmer M, Jinno S, Huckle AL, Hamidi H, Ross RS, Zent R, Ballestrem C, Lennon R, Ishibe S. PMID: 29241625; PMCID: PMC5846847.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    17. Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6250-E6259. Manso AM, Okada H, Sakamoto FM, Moreno E, Monkley SJ, Li R, Critchley DR, Ross RS. PMID: 28698364; PMCID: PMC5544289.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    18. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM. PMID: 28498861; PMCID: PMC5428970.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    19. CRISPR/Cas9-mediated gene manipulation to create single-amino-acid-substituted and floxed mice with a cloning-free method. Sci Rep. 2017 02 08; 7:42244. Ma X, Chen C, Veevers J, Zhou X, Ross RS, Feng W, Chen J. PMID: 28176880; PMCID: PMC5296764.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    20. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. PMID: 27500929; PMCID: PMC4976940.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure. Circ Heart Fail. 2016 08; 9(8). Zhang Z, Mu Y, Veevers J, Peter AK, Manso AM, Bradford WH, Dalton ND, Peterson KL, Knowlton KU, Ross RS, Zhou X, Chen J. PMID: 27502369; PMCID: PMC4979611.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    22. Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial. JAMA Cardiol. 2016 05 01; 1(2):163-71. Hammond HK, Penny WF, Traverse JH, Henry TD, Watkins MW, Yancy CW, Sweis RN, Adler ED, Patel AN, Murray DR, Ross RS, Bhargava V, Maisel A, Barnard DD, Lai NC, Dalton ND, Lee ML, Narayan SM, Blanchard DG, Gao MH. PMID: 27437887; PMCID: PMC5535743.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCellsCTClinical Trials
    23. Integrins and integrin-related proteins in cardiac fibrosis. J Mol Cell Cardiol. 2016 04; 93:162-74. Chen C, Li R, Ross RS, Manso AM. PMID: 26562414; PMCID: PMC4846493.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    24. Caveolin modulates integrin function and mechanical activation in the cardiomyocyte. FASEB J. 2015 Feb; 29(2):374-84. Israeli-Rosenberg S, Chen C, Li R, Deussen DN, Niesman IR, Okada H, Patel HH, Roth DM, Ross RS. PMID: 25366344; PMCID: PMC4314226.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Integrins and integrin-associated proteins in the cardiac myocyte. Circ Res. 2014 Jan 31; 114(3):572-586. Israeli-Rosenberg S, Manso AM, Okada H, Ross RS. PMID: 24481847; PMCID: PMC3975046.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    26. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014 Mar 01; 127(Pt 5):1104-16. Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross RS. PMID: 24413171; PMCID: PMC3937777.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    27. A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Aging Cell. 2014 Jun; 13(3):431-40. Nishimura M, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan H, Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen M, Ocorr K. PMID: 24400780; PMCID: PMC4032615.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    28. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. PMID: 24091324; PMCID: PMC3784521.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    29. Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol. 2013 Jul 08; 202(1):163-77. Thievessen I, Thompson PM, Berlemont S, Plevock KM, Plotnikov SV, Zemljic-Harpf A, Ross RS, Davidson MW, Danuser G, Campbell SL, Waterman CM. PMID: 23836933; PMCID: PMC3704983.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    30. Deletion of the cell adhesion adaptor protein vinculin disturbs the localization of GFAP in Bergmann glial cells. Glia. 2013 Jul; 61(7):1067-83. Winkler U, Hirrlinger PG, Sestu M, Wilhelm F, Besser S, Zemljic-Harpf AE, Ross RS, Bornschein G, Krügel U, Ziegler WH, Hirrlinger J. PMID: 23595642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    31. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 02; 104(7):1623-33. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. PMID: 23561539; PMCID: PMC3617425.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    32. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 08; 288(6):4252-64. Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS. PMID: 23266827; PMCID: PMC3567677.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    33. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. PMID: 22859372; PMCID: PMC4050367.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    34. New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Eur J Cell Biol. 2012 Mar; 91(3):180-91. Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ. PMID: 22306379; PMCID: PMC3629562.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    35. β1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses. Am J Pathol. 2012 Mar; 180(3):952-962. Li R, Wu Y, Manso AM, Gu Y, Liao P, Israeli S, Yajima T, Nguyen U, Huang MS, Dalton ND, Peterson KL, Ross RS. PMID: 22248583; PMCID: PMC3349893.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    36. β1D chain increases α7β1 integrin and laminin and protects against sarcolemmal damage in mdx mice. Hum Mol Genet. 2012 Apr 01; 21(7):1592-603. Liu J, Milner DJ, Boppart MD, Ross RS, Kaufman SJ. PMID: 22180459; PMCID: PMC3298282.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    37. The costamere bridges sarcomeres to the sarcolemma in striated muscle. Prog Pediatr Cardiol. 2011 May; 31(2):83-88. Peter AK, Cheng H, Ross RS, Knowlton KU, Chen J. PMID: 24039381; PMCID: PMC3770312.
      View in: PubMed   Mentions: 63  
    38. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. PMID: 20981782; PMCID: PMC3272305.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    39. Vinculin and talin: focus on the myocardium. J Investig Med. 2009 Dec; 57(8):849-55. Zemljic-Harpf A, Manso AM, Ross RS. PMID: 19952892; PMCID: PMC2810504.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    40. Integrins, focal adhesions, and cardiac fibroblasts. J Investig Med. 2009 Dec; 57(8):856-60. Manso AM, Kang SM, Ross RS. PMID: 19952893; PMCID: PMC2810503.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    41. Cell-cell connection to cardiac disease. Trends Cardiovasc Med. 2009 Aug; 19(6):182-90. Sheikh F, Ross RS, Chen J. PMID: 20211433; PMCID: PMC3601820.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    42. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F210-7. Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush KT, Vera DR, Ross RS, Nigam SK. PMID: 19439520; PMCID: PMC2711709.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    43. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb; 16(2):233-44. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D. PMID: 19217425; PMCID: PMC2664087.
      View in: PubMed   Mentions: 284     Fields:    Translation:AnimalsCells
    44. Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H627-38. Manso AM, Kang SM, Plotnikov SV, Thievessen I, Oh J, Beggs HE, Ross RS. PMID: 19136609; PMCID: PMC2660223.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    45. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Diabetes. 2008 Sep; 57(9):2470-9. Caglayan E, Stauber B, Collins AR, Lyon CJ, Yin F, Liu J, Rosenkranz S, Erdmann E, Peterson LE, Ross RS, Tangirala RK, Hsueh WA. PMID: 18511847; PMCID: PMC2518499.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    46. Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. Circ Res. 2008 May 09; 102(9):1109-17. Elsherif L, Huang MS, Shai SY, Yang Y, Li RY, Chun J, Mekany MA, Chu AL, Kaufman SJ, Ross RS. PMID: 18340010.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    47. Models that Buzz, Squeak, Ribbit and Oink: Using a Variety of Species to Study Cardiovascular Disease. Drug Discov Today Dis Models. 2008; 5(3):113-115. Ross RS, Chen J. PMID: 19802370; PMCID: PMC2734110.
      View in: PubMed   Mentions:
    48. Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling. Mol Cell Biol. 2008 Jan; 28(2):794-802. Lei L, Liu D, Huang Y, Jovin I, Shai SY, Kyriakides T, Ross RS, Giordano FJ. PMID: 17984225; PMCID: PMC2223431.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    49. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov; 27(21):7522-37. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross RS. PMID: 17785437; PMCID: PMC2169049.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    50. Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger. J Card Fail. 2007 May; 13(4):318-29. Roos KP, Jordan MC, Fishbein MC, Ritter MR, Friedlander M, Chang HC, Rahgozar P, Han T, Garcia AJ, Maclellan WR, Ross RS, Philipson KD. PMID: 17517353; PMCID: PMC2017112.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    51. Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins. J Mol Cell Cardiol. 2007 Mar; 42(3):653-61. Menon B, Johnson JN, Ross RS, Singh M, Singh K. PMID: 17292911; PMCID: PMC1894917.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    52. Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway. Basic Res Cardiol. 2006 Nov; 101(6):485-93. Menon B, Krishnamurthy P, Kaverina E, Johnson JN, Ross RS, Singh M, Singh K. PMID: 16783488.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    53. Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm. 2006 Jun; 3(6):728-36. Oh YS, Jong AY, Kim DT, Li H, Wang C, Zemljic-Harpf A, Ross RS, Fishbein MC, Chen PS, Chen LS. PMID: 16731479.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    54. Integrins, membrane-type matrix metalloproteinases and ADAMs: potential implications for cardiac remodeling. Cardiovasc Res. 2006 Feb 15; 69(3):574-84. Manso AM, Elsherif L, Kang SM, Ross RS. PMID: 16253214.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    55. beta-Adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of beta1 integrin signaling and mitochondrial pathway. Am J Physiol Cell Physiol. 2006 Jan; 290(1):C254-61. Menon B, Singh M, Ross RS, Johnson JN, Singh K. PMID: 16148033.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    56. The Na+/Ca2+ exchanger/SR Ca2+ ATPase transport capacity regulates the contractility of normal and hypertrophied feline ventricular myocytes. J Card Fail. 2005 Jun; 11(5):380-7. Weisser-Thomas J, Kubo H, Hefner CA, Gaughan JP, McGowan BS, Ross R, Meyer M, Dillmann W, Houser SR. PMID: 15948089.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    57. Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol. 2004 Sep; 165(3):1033-44. Zemljic-Harpf AE, Ponrartana S, Avalos RT, Jordan MC, Roos KP, Dalton ND, Phan VQ, Adamson ED, Ross RS. PMID: 15331426; PMCID: PMC1618594.
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    60. Overexpression of the integrin beta(1A) subunit and the beta(1A) cytoplasmic domain modifies the beta-adrenergic regulation of the cardiac L-type Ca(2+)current. J Mol Cell Cardiol. 2004 Jun; 36(6):809-19. Cheng Q, Ross RS, Walsh KB. PMID: 15158122.
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    65. PET imaging in small animals. J Nucl Cardiol. 2003 Sep-Oct; 10(5):513-20. Schelbert HR, Inubushi M, Ross RS. PMID: 14569245.
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    67. Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src. J Mol Cell Cardiol. 2003 Jun; 35(6):671-83. Willey CD, Balasubramanian S, Rodríguez Rosas MC, Ross RS, Kuppuswamy D. PMID: 12788385.
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    68. The extracellular connections: the role of integrins in myocardial remodeling. J Card Fail. 2002 Dec; 8(6 Suppl):S326-31. Ross RS. PMID: 12555140.
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    69. Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Histochem Cell Biol. 2002 Dec; 118(6):431-9. Babbitt CJ, Shai SY, Harpf AE, Pham CG, Ross RS. PMID: 12483308.
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    70. Cyclosporin A regulates sodium-calcium exchanger (NCX1) gene expression in vitro and cardiac hypertrophy in NCX1 transgenic mice. Ann N Y Acad Sci. 2002 Nov; 976:259-67. Jordan MC, Quednau BD, Roos KP, Ross RS, Philipson KD, Nicholas SB. PMID: 12502568.
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    71. Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors. Circ Res. 2002 Jul 26; 91(2):90-2. Reuter H, Henderson SA, Han T, Matsuda T, Baba A, Ross RS, Goldhaber JI, Philipson KD. PMID: 12142340.
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    72. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002 Mar 08; 90(4):458-64. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross RS. PMID: 11884376.
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    73. The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002 Feb 22; 90(3):305-8. Reuter H, Henderson SA, Han T, Ross RS, Goldhaber JI, Philipson KD. PMID: 11861419.
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    74. Integrins and the myocardium. Genet Eng (N Y). 2002; 24:87-105. Shai SY, Harpf AE, Ross RS. PMID: 12416302.
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