Carolyn Worby

Title(s)Project Scientist, Pharmacology
SchoolHealth Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    Lafora Epilepsy - Basic mechanisms to therapy
    NIH P01NS097197Jul 1, 2016 - Jun 30, 2021
    Role: Co-Investigator
    Fic-mediated Adenylylation
    NIH/NIGMS R01GM090328May 15, 2004 - Jul 31, 2014
    Role: Principal Investigator
    NIH/NINDS R29NS028496Apr 1, 1990 - Mar 31, 1996
    Role: Principal Investigator
    Novel Secreted Kinases
    NIH/NIDDK R01DK018024Jun 1, 1979 - Jul 31, 2019
    Role: Principal Investigator
    Regulation and Function of the Secretory Phosphoproteome
    NIH/NIDDK R01DK018849May 1, 1976 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Worby CA, Dixon JE. Reversible phosphorylation: a birthday tribute to Herb Tabor. J Biol Chem. 2019 Feb 01; 294(5):1638-1642. PMID: 30710011.
      View in: PubMed
    2. Sanyal A, Chen AJ, Nakayasu ES, Lazar CS, Zbornik EA, Worby CA, Koller A, Mattoo S. A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. J Biol Chem. 2015 Mar 27; 290(13):8482-99. PMID: 25601083.
      View in: PubMed
    3. Worby CA, Dixon JE. Unpacking the unfolded protein response. Cell. 2014 Sep 11; 158(6):1221-1224. PMID: 25215479.
      View in: PubMed
    4. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-1044. PMID: 25171405; PMCID: PMC4149754.
    5. Worby CA, Dixon JE. PTEN. Annu Rev Biochem. 2014; 83:641-69. PMID: 24905788.
      View in: PubMed
    6. Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon JE, Zhang J. Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica. J Biol Chem. 2013 Feb 15; 288(7):5176-85. PMID: 23293031; PMCID: PMC3576122.
    7. Sherwood AR, Paasch BC, Worby CA, Gentry MS. A malachite green-based assay to assess glucan phosphatase activity. Anal Biochem. 2013 Apr 01; 435(1):54-6. PMID: 23201267.
      View in: PubMed
    8. Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science. 2012 Jun 01; 336(6085):1150-3. PMID: 22582013; PMCID: PMC3754843.
    9. Lo KL, Kimball RA, Lehmann J, Gershwin LJ, Worby C, Corbeil LB. Antibody responses of calves to Histophilus somni recombinant IbpA subunits. Comp Immunol Microbiol Infect Dis. 2012 Sep; 35(5):453-9. PMID: 22554920.
      View in: PubMed
    10. DePaoli-Roach AA, Segvich DM, Meyer CM, Rahimi Y, Worby CA, Gentry MS, Roach PJ. Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity. Hum Mol Genet. 2012 Apr 01; 21(7):1604-10. PMID: 22186021; PMCID: PMC3298283.
    11. Romá-Mateo C, Solaz-Fuster Mdel C, Gimeno-Alcañiz JV, Dukhande VV, Donderis J, Worby CA, Marina A, Criado O, Koller A, Rodriguez De Cordoba S, Gentry MS, Sanz P. Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase. Biochem J. 2011 Oct 15; 439(2):265-75. PMID: 21728993; PMCID: PMC3299407.
    12. Mattoo S, Durrant E, Chen MJ, Xiao J, Lazar CS, Manning G, Dixon JE, Worby CA. Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. J Biol Chem. 2011 Sep 16; 286(37):32834-42. PMID: 21795713; PMCID: PMC3173180.
    13. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. PMID: 21641550; PMCID: PMC3119201.
    14. Worby CA, Dixon JE. Glycogen synthase: an old enzyme with a new trick. Cell Metab. 2011 Mar 02; 13(3):233-4. PMID: 21356510.
      View in: PubMed
    15. Xiao J, Worby CA, Mattoo S, Sankaran B, Dixon JE. Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol. 2010 Aug; 17(8):1004-10. PMID: 20622875; PMCID: PMC2920259.
    16. Zekarias B, Mattoo S, Worby C, Lehmann J, Rosenbusch RF, Corbeil LB. Histophilus somni IbpA DR2/Fic in virulence and immunoprotection at the natural host alveolar epithelial barrier. Infect Immun. 2010 May; 78(5):1850-8. PMID: 20176790; PMCID: PMC2863524.
    17. Gentry MS, Dixon JE, Worby CA. Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci. 2009 Dec; 34(12):628-39. PMID: 19818631.
      View in: PubMed
    18. Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE. The fic domain: regulation of cell signaling by adenylylation. Mol Cell. 2009 Apr 10; 34(1):93-103. PMID: 19362538; PMCID: PMC2820730.
    19. Geertsema RS, Worby C, Kruger RP, Tagawa Y, Russo R, Herdman DS, Lo K, Kimball RA, Dixon J, Corbeil LB. Protection of mice against H. somni septicemia by vaccination with recombinant immunoglobulin binding protein subunits. Vaccine. 2008 Aug 18; 26(35):4506-12. PMID: 18590787; PMCID: PMC2659705.
    20. Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, Okamura Y. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):7970-5. PMID: 18524949; PMCID: PMC2430346.
    21. Worby CA, Gentry MS, Dixon JE. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). J Biol Chem. 2008 Feb 15; 283(7):4069-76. PMID: 18070875; PMCID: PMC2251628.
    22. Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel AR. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 01; 21(19):2399-409. PMID: 17908927; PMCID: PMC1993871.
    23. Gentry MS, Dowen RH, Worby CA, Mattoo S, Ecker JR, Dixon JE. The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol. 2007 Jul 30; 178(3):477-88. PMID: 17646401; PMCID: PMC2064834.
    24. Worby CA, Gentry MS, Dixon JE. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem. 2006 Oct 13; 281(41):30412-8. PMID: 16901901; PMCID: PMC2774450.
    25. Worby CA, Dixon JE. Microbiology. Bacteria seize control by acetylating host proteins. Science. 2006 May 26; 312(5777):1150-1. PMID: 16731519.
      View in: PubMed
    26. Worby CA, Dixon JE. Phosphoinositide phosphatases: emerging roles as voltage sensors? Mol Interv. 2005 Oct; 5(5):274-7. PMID: 16249522.
      View in: PubMed
    27. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell. 2005 Jul 22; 19(2):197-207. PMID: 16039589.
      View in: PubMed
    28. Gentry MS, Worby CA, Dixon JE. Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8501-6. PMID: 15930137; PMCID: PMC1150849.
    29. Pagliarini DJ, Worby CA, Dixon JE. A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem. 2004 Sep 10; 279(37):38590-6. PMID: 15247229.
      View in: PubMed
    30. Worby CA, Dixon JE. RNA interference in cultured Drosophila cells. Curr Protoc Mol Biol. 2004 Feb; Chapter 26:Unit 26.5. PMID: 18265350.
      View in: PubMed
    31. Worby CA, Dixon JE. Sorting out the cellular functions of sorting nexins. Nat Rev Mol Cell Biol. 2002 Dec; 3(12):919-31. PMID: 12461558.
      View in: PubMed
    32. Muda M, Worby CA, Simonson-Leff N, Clemens JC, Dixon JE. Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Biochem J. 2002 Aug 15; 366(Pt 1):73-7. PMID: 12014990; PMCID: PMC1222762.
    33. Worby CA, Simonson-Leff N, Clemens JC, Huddler D, Muda M, Dixon JE. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002 Mar 15; 277(11):9422-8. PMID: 11773052.
      View in: PubMed
    34. Worby CA, Simonson-Leff N, Clemens JC, Kruger RP, Muda M, Dixon JE. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. J Biol Chem. 2001 Nov 09; 276(45):41782-9. PMID: 11546816.
      View in: PubMed
    35. Worby CA, Simonson-Leff N, Dixon JE. RNA interference of gene expression (RNAi) in cultured Drosophila cells. Sci STKE. 2001 Aug 14; 2001(95):pl1. PMID: 11752672.
      View in: PubMed
    36. Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000 Jun 09; 101(6):671-84. PMID: 10892653.
      View in: PubMed
    37. Clemens JC, Worby CA, Simonson-Leff N, Muda M, Maehama T, Hemmings BA, Dixon JE. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6499-503. PMID: 10823906; PMCID: PMC18635.
    38. Worby CA. Cloning neuropeptide tyrosine cDNA. Methods Mol Biol. 2000; 153:3-11. PMID: 10957980.
      View in: PubMed
    39. Worby CA, Vega QC, Chao HH, Seasholtz AF, Thompson RC, Dixon JE. Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J Biol Chem. 1998 Feb 06; 273(6):3502-8. PMID: 9452475.
      View in: PubMed
    40. Vega QC, Worby CA, Lechner MS, Dixon JE, Dressler GR. Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10657-61. PMID: 8855235; PMCID: PMC38210.
    41. Worby CA, Vega QC, Zhao Y, Chao HH, Seasholtz AF, Dixon JE. Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. J Biol Chem. 1996 Sep 27; 271(39):23619-22. PMID: 8798576.
      View in: PubMed
    42. Liu X, Vega QC, Decker RA, Pandey A, Worby CA, Dixon JE. Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities. J Biol Chem. 1996 Mar 08; 271(10):5309-12. PMID: 8621380.
      View in: PubMed