Loading...

Carolyn Worby

Title(s)PROJ SCIENTIST-FY NON REP, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0721
La Jolla CA 92093
Phone8/8-22--4007
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Lafora Epilepsy - Basic mechanisms to therapy
    NIH P01NS097197Jul 1, 2016 - Jun 30, 2021
    Role: Co-Investigator
    Fic-mediated Adenylylation
    NIH/NIGMS R01GM090328May 15, 2004 - Jul 31, 2014
    Role: Principal Investigator
    Regulation and Function of the Secretory Phosphoproteome
    NIH/NIDDK R01DK018849Oct 1, 1991 - Sep 30, 1991
    Role: Principal Investigator
    REGULATION OF NEUROPEPTIDE Y GENE EXPRESSION
    NIH/NINDS R29NS028496Apr 1, 1990 - Mar 31, 1996
    Role: Principal Investigator
    Novel Secreted Kinases
    NIH/NIDDK R01DK018024Jun 1, 1979 - May 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic. Epilepsy Behav. 2020 02; 103(Pt A):106839. Gentry MS, Afawi Z, Armstrong DD, Delgado-Escueta A, Goldberg YP, Grossman TR, Guinovart JJ, Harris F, Hurley TD, Michelucci R, Minassian BA, Sanz P, Worby CA, Serratosa JM. PMID: 31932179.
      View in: PubMed   Mentions: 1     Fields:    
    2. Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans. J Cell Biol. 2019 11 04; 218(11):3795-3811. Gerson-Gurwitz A, Worby CA, Lee KY, Khaliullin R, Bouffard J, Cheerambathur D, Oegema K, Cram EJ, Dixon JE, Desai A. PMID: 31541016.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Reversible phosphorylation: a birthday tribute to Herb Tabor. J Biol Chem. 2019 02 01; 294(5):1638-1642. Worby CA, Dixon JE. PMID: 30710011.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. J Biol Chem. 2015 Mar 27; 290(13):8482-99. Sanyal A, Chen AJ, Nakayasu ES, Lazar CS, Zbornik EA, Worby CA, Koller A, Mattoo S. PMID: 25601083.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    5. Unpacking the unfolded protein response. Cell. 2014 Sep 11; 158(6):1221-1224. Worby CA, Dixon JE. PMID: 25215479.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-1044. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. PMID: 25171405.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    7. PTEN. Annu Rev Biochem. 2014; 83:641-69. Worby CA, Dixon JE. PMID: 24905788.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    8. Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica. J Biol Chem. 2013 Feb 15; 288(7):5176-85. Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon JE, Zhang J. PMID: 23293031.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. A malachite green-based assay to assess glucan phosphatase activity. Anal Biochem. 2013 Apr 01; 435(1):54-6. Sherwood AR, Paasch BC, Worby CA, Gentry MS. PMID: 23201267.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science. 2012 Jun 01; 336(6085):1150-3. Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE. PMID: 22582013.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    11. Antibody responses of calves to Histophilus somni recombinant IbpA subunits. Comp Immunol Microbiol Infect Dis. 2012 Sep; 35(5):453-9. Lo KL, Kimball RA, Lehmann J, Gershwin LJ, Worby C, Corbeil LB. PMID: 22554920.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity. Hum Mol Genet. 2012 Apr 01; 21(7):1604-10. DePaoli-Roach AA, Segvich DM, Meyer CM, Rahimi Y, Worby CA, Gentry MS, Roach PJ. PMID: 22186021.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase. Biochem J. 2011 Oct 15; 439(2):265-75. Romá-Mateo C, Solaz-Fuster Mdel C, Gimeno-Alcañiz JV, Dukhande VV, Donderis J, Worby CA, Marina A, Criado O, Koller A, Rodriguez De Cordoba S, Gentry MS, Sanz P. PMID: 21728993.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. J Biol Chem. 2011 Sep 16; 286(37):32834-42. Mattoo S, Durrant E, Chen MJ, Xiao J, Lazar CS, Manning G, Dixon JE, Worby CA. PMID: 21795713.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    15. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. PMID: 21641550.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    16. Glycogen synthase: an old enzyme with a new trick. Cell Metab. 2011 Mar 02; 13(3):233-4. Worby CA, Dixon JE. PMID: 21356510.
      View in: PubMed   Mentions:    Fields:    
    17. Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol. 2010 Aug; 17(8):1004-10. Xiao J, Worby CA, Mattoo S, Sankaran B, Dixon JE. PMID: 20622875.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    18. Histophilus somni IbpA DR2/Fic in virulence and immunoprotection at the natural host alveolar epithelial barrier. Infect Immun. 2010 May; 78(5):1850-8. Zekarias B, Mattoo S, Worby C, Lehmann J, Rosenbusch RF, Corbeil LB. PMID: 20176790.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    19. Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci. 2009 Dec; 34(12):628-39. Gentry MS, Dixon JE, Worby CA. PMID: 19818631.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    20. The fic domain: regulation of cell signaling by adenylylation. Mol Cell. 2009 Apr 10; 34(1):93-103. Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE. PMID: 19362538.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    21. Protection of mice against H. somni septicemia by vaccination with recombinant immunoglobulin binding protein subunits. Vaccine. 2008 Aug 18; 26(35):4506-12. Geertsema RS, Worby C, Kruger RP, Tagawa Y, Russo R, Herdman DS, Lo K, Kimball RA, Dixon J, Corbeil LB. PMID: 18590787.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):7970-5. Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, Okamura Y. PMID: 18524949.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    23. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). J Biol Chem. 2008 Feb 15; 283(7):4069-76. Worby CA, Gentry MS, Dixon JE. PMID: 18070875.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    24. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 01; 21(19):2399-409. Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel AR. PMID: 17908927.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    25. The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol. 2007 Jul 30; 178(3):477-88. Gentry MS, Dowen RH, Worby CA, Mattoo S, Ecker JR, Dixon JE. PMID: 17646401.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    26. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem. 2006 Oct 13; 281(41):30412-8. Worby CA, Gentry MS, Dixon JE. PMID: 16901901.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    27. Microbiology. Bacteria seize control by acetylating host proteins. Science. 2006 May 26; 312(5777):1150-1. Worby CA, Dixon JE. PMID: 16731519.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    28. Phosphoinositide phosphatases: emerging roles as voltage sensors? Mol Interv. 2005 Oct; 5(5):274-7. Worby CA, Dixon JE. PMID: 16249522.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    29. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell. 2005 Jul 22; 19(2):197-207. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE. PMID: 16039589.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    30. Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8501-6. Gentry MS, Worby CA, Dixon JE. PMID: 15930137.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    31. A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem. 2004 Sep 10; 279(37):38590-6. Pagliarini DJ, Worby CA, Dixon JE. PMID: 15247229.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    32. RNA interference in cultured Drosophila cells. Curr Protoc Mol Biol. 2004 Feb; Chapter 26:Unit 26.5. Worby CA, Dixon JE. PMID: 18265350.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    33. Sorting out the cellular functions of sorting nexins. Nat Rev Mol Cell Biol. 2002 Dec; 3(12):919-31. Worby CA, Dixon JE. PMID: 12461558.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    34. Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Biochem J. 2002 Aug 15; 366(Pt 1):73-7. Muda M, Worby CA, Simonson-Leff N, Clemens JC, Dixon JE. PMID: 12014990.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    35. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002 Mar 15; 277(11):9422-8. Worby CA, Simonson-Leff N, Clemens JC, Huddler D, Muda M, Dixon JE. PMID: 11773052.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    Carolyn's Networks
    Concepts (262)
    Derived automatically from this person's publications.
    _
    Co-Authors (7)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _