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    Carolyn Worby

    TitleProject Scientist
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0721
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Lafora Epilepsy - Basic mechanisms to therapy
      NIH P01NS097197Jul 1, 2016 - Jun 30, 2021
      Role: Co-Investigator
      Fic-mediated Adenylylation
      NIH/NIGMS R01GM090328May 15, 2004 - Jul 31, 2014
      Role: Principal Investigator
      NIH/NINDS R29NS028496Apr 1, 1990 - Mar 31, 1996
      Role: Principal Investigator
      Novel Secreted Kinases
      NIH/NIDDK R01DK018024Jun 1, 1979 - Jul 31, 2019
      Role: Principal Investigator
      Novel Protein Phosphatases
      NIH/NIDDK R01DK018849May 1, 1976 - Jun 30, 2021
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sanyal A, Chen AJ, Nakayasu ES, Lazar CS, Zbornik EA, Worby C, Koller A, Mattoo S. A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. J Biol Chem. 2015 Mar 27; 290(13):8482-99. PMID: 25601083; PMCID: PMC4375499.
      2. Worby C, Dixon JE. Unpacking the unfolded protein response. Cell. 2014 Sep 11; 158(6):1221-1224. PMID: 25215479.
        View in: PubMed
      3. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-1044. PMID: 25171405; PMCID: PMC4149754.
      4. Worby C, Dixon JE. PTEN. Annu Rev Biochem. 2014; 83:641-69. PMID: 24905788.
        View in: PubMed
      5. Sherwood AR, Paasch BC, Worby C, Gentry MS. A malachite green-based assay to assess glucan phosphatase activity. Anal Biochem. 2013 Apr 01; 435(1):54-6. PMID: 23201267; PMCID: PMC3577954.
      6. Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby C, Kinch LN, Xiao J, Grishin NV, Dixon JE. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science. 2012 Jun 01; 336(6085):1150-3. PMID: 22582013; PMCID: PMC3754843.
      7. Lo KL, Kimball RA, Lehmann J, Gershwin LJ, Worby C, Corbeil LB. Antibody responses of calves to Histophilus somni recombinant IbpA subunits. Comp Immunol Microbiol Infect Dis. 2012 Sep; 35(5):453-9. PMID: 22554920.
        View in: PubMed
      8. DePaoli-Roach AA, Segvich DM, Meyer CM, Rahimi Y, Worby C, Gentry MS, Roach PJ. Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity. Hum Mol Genet. 2012 Apr 01; 21(7):1604-10. PMID: 22186021; PMCID: PMC3298283.
      9. Romá-Mateo C, Solaz-Fuster Mdel C, Gimeno-Alcañiz JV, Dukhande VV, Donderis J, Worby C, Marina A, Criado O, Koller A, Rodriguez De Cordoba S, Gentry MS, Sanz P. Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase. Biochem J. 2011 Oct 15; 439(2):265-75. PMID: 21728993; PMCID: PMC3299407.
      10. Mattoo S, Durrant E, Chen MJ, Xiao J, Lazar CS, Manning G, Dixon JE, Worby C. Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. J Biol Chem. 2011 Sep 16; 286(37):32834-42. PMID: 21795713; PMCID: PMC3173180.
      11. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby C, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. PMID: 21641550; PMCID: PMC3119201.
      12. Geertsema RS, Zekarias B, La Franco Scheuch L, Worby C, Russo R, Gershwin LJ, Herdman DS, Lo K, Corbeil LB. IbpA DR2 subunit immunization protects calves against Histophilus somni pneumonia. Vaccine. 2011 Jun 24; 29(29-30):4805-12. PMID: 21557979.
        View in: PubMed
      13. Worby C, Dixon JE. Glycogen synthase: an old enzyme with a new trick. Cell Metab. 2011 Mar 02; 13(3):233-4. PMID: 21356510.
        View in: PubMed
      14. Xiao J, Worby C, Mattoo S, Sankaran B, Dixon JE. Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol. 2010 Aug; 17(8):1004-10. PMID: 20622875; PMCID: PMC2920259.
      15. Zekarias B, Mattoo S, Worby C, Lehmann J, Rosenbusch RF, Corbeil LB. Histophilus somni IbpA DR2/Fic in virulence and immunoprotection at the natural host alveolar epithelial barrier. Infect Immun. 2010 May; 78(5):1850-8. PMID: 20176790; PMCID: PMC2863524.
      16. Gentry MS, Dixon JE, Worby C. Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci. 2009 Dec; 34(12):628-39. PMID: 19818631; PMCID: PMC2805077.
      17. Worby C, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE. The fic domain: regulation of cell signaling by adenylylation. Mol Cell. 2009 Apr 10; 34(1):93-103. PMID: 19362538; PMCID: PMC2820730.
      18. Geertsema RS, Worby C, Kruger RP, Tagawa Y, Russo R, Herdman DS, Lo K, Kimball RA, Dixon J, Corbeil LB. Protection of mice against H. somni septicemia by vaccination with recombinant immunoglobulin binding protein subunits. Vaccine. 2008 Aug 18; 26(35):4506-12. PMID: 18590787; PMCID: PMC2659705.
      19. Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby C, Dixon JE, McCormack T, Sasaki T, Okamura Y. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):7970-5. PMID: 18524949; PMCID: PMC2430346.
      20. Worby C, Gentry MS, Dixon JE. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). J Biol Chem. 2008 Feb 15; 283(7):4069-76. PMID: 18070875; PMCID: PMC2251628.
      21. Cheng A, Zhang M, Gentry MS, Worby C, Dixon JE, Saltiel AR. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 01; 21(19):2399-409. PMID: 17908927; PMCID: PMC1993871.
      22. Gentry MS, Dowen RH, Worby C, Mattoo S, Ecker JR, Dixon JE. The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol. 2007 Jul 30; 178(3):477-88. PMID: 17646401; PMCID: PMC2064834.
      23. Worby C, Gentry MS, Dixon JE. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem. 2006 Oct 13; 281(41):30412-8. PMID: 16901901; PMCID: PMC2774450.
      24. Worby C, Dixon JE. Microbiology. Bacteria seize control by acetylating host proteins. Science. 2006 May 26; 312(5777):1150-1. PMID: 16731519.
        View in: PubMed
      25. Worby C, Dixon JE. Phosphoinositide phosphatases: emerging roles as voltage sensors? Mol Interv. 2005 Oct; 5(5):274-7. PMID: 16249522.
        View in: PubMed
      26. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby C, Casey PJ, Dixon JE. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell. 2005 Jul 22; 19(2):197-207. PMID: 16039589.
        View in: PubMed
      27. Gentry MS, Worby C, Dixon JE. Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8501-6. PMID: 15930137; PMCID: PMC1150849.
      28. Pagliarini DJ, Worby C, Dixon JE. A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem. 2004 Sep 10; 279(37):38590-6. PMID: 15247229.
        View in: PubMed
      29. Worby C, Dixon JE. RNA interference in cultured Drosophila cells. Curr Protoc Mol Biol. 2004 Feb; Chapter 26:Unit 26.5. PMID: 18265350.
        View in: PubMed
      30. Worby C, Dixon JE. Sorting out the cellular functions of sorting nexins. Nat Rev Mol Cell Biol. 2002 Dec; 3(12):919-31. PMID: 12461558.
        View in: PubMed
      31. Muda M, Worby C, Simonson-Leff N, Clemens JC, Dixon JE. Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Biochem J. 2002 Aug 15; 366(Pt 1):73-7. PMID: 12014990; PMCID: PMC1222762.
      32. Worby C, Simonson-Leff N, Clemens JC, Huddler D, Muda M, Dixon JE. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002 Mar 15; 277(11):9422-8. PMID: 11773052.
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      33. Worby C, Simonson-Leff N, Clemens JC, Kruger RP, Muda M, Dixon JE. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. J Biol Chem. 2001 Nov 09; 276(45):41782-9. PMID: 11546816.
        View in: PubMed
      34. Worby C, Simonson-Leff N, Dixon JE. RNA interference of gene expression (RNAi) in cultured Drosophila cells. Sci STKE. 2001 Aug 14; 2001(95):pl1. PMID: 11752672.
        View in: PubMed
      35. Worby C, Margolis B. Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5. Sci STKE. 2000 Dec 19; 2000(63):pe2. PMID: 11752629.
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      36. Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds. J Mol Biol. 2000 Aug 11; 301(2):433-50. PMID: 10926519.
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      37. Schmucker D, Clemens JC, Shu H, Worby C, Xiao J, Muda M, Dixon JE, Zipursky SL. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000 Jun 09; 101(6):671-84. PMID: 10892653.
        View in: PubMed
      38. Clemens JC, Worby C, Simonson-Leff N, Muda M, Maehama T, Hemmings BA, Dixon JE. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6499-503. PMID: 10823906; PMCID: PMC18635.
      39. Worby C. Cloning neuropeptide tyrosine cDNA. Methods Mol Biol. 2000; 153:3-11. PMID: 10957980.
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      40. Lee TT, Worby C, Bao ZQ, Dixon JE, Colman RF. His68 and His141 are critical contributors to the intersubunit catalytic site of adenylosuccinate lyase of Bacillus subtilis. Biochemistry. 1999 Jan 05; 38(1):22-32. PMID: 9890879.
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      41. Barnea A, Aguila-Mansilla N, Bigio EH, Worby C, Roberts J. Evidence for regulated expression of neuropeptide Y gene by rat and human cultured astrocytes. Regul Pept. 1998 Sep 25; 75-76:293-300. PMID: 9802422.
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      42. Lee TT, Worby C, Bao ZQ, Dixon JE, Colman RF. Implication of His68 in the substrate site of Bacillus subtilis adenylosuccinate lyase by mutagenesis and affinity labeling with 2-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-monophosphate. Biochemistry. 1998 Jun 09; 37(23):8481-9. PMID: 9622500.
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      43. Worby C, Vega QC, Chao HH, Seasholtz AF, Thompson RC, Dixon JE. Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J Biol Chem. 1998 Feb 06; 273(6):3502-8. PMID: 9452475.
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      44. Lee TT, Worby C, Dixon JE, Colman RF. Identification of His141 in the active site of Bacillus subtilis adenylosuccinate lyase by affinity labeling with 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate. J Biol Chem. 1997 Jan 03; 272(1):458-65. PMID: 8995283.
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      45. Vega QC, Worby C, Lechner MS, Dixon JE, Dressler GR. Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10657-61. PMID: 8855235; PMCID: PMC38210.
      46. Worby C, Vega QC, Zhao Y, Chao HH, Seasholtz AF, Dixon JE. Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. J Biol Chem. 1996 Sep 27; 271(39):23619-22. PMID: 8798576.
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      47. Liu X, Vega QC, Decker RA, Pandey A, Worby C, Dixon JE. Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities. J Biol Chem. 1996 Mar 08; 271(10):5309-12. PMID: 8621380.
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