Alexander Skupin

Title(s)ASSOC PROJ SCIENTIST (WOS), Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts. Genome Med. 2024 Apr 02; 16(1):51. Yabo YA, Moreno-Sanchez PM, Pires-Afonso Y, Kaoma T, Nosirov B, Scafidi A, Ermini L, Lipsa A, Oudin A, Kyriakis D, Grzyb K, Poovathingal SK, Poli A, Muller A, Toth R, Klink B, Berchem G, Berthold C, Hertel F, Mittelbronn M, Heiland DH, Skupin A, Nazarov PV, Niclou SP, Michelucci A, Golebiewska A. PMID: 38566128; PMCID: PMC10988817.
      View in: PubMed   Mentions:    Fields:    
    2. Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations. Cell Death Discov. 2024 Mar 07; 10(1):119. Ali M, Garcia P, Lunkes LP, Sciortino A, Thomas M, Heurtaux T, Grzyb K, Halder R, Coowar D, Skupin A, Buée L, Blum D, Buttini M, Glaab E. PMID: 38453894; PMCID: PMC10920792.
      View in: PubMed   Mentions:
    3. Calcium oscillations optimize the energetic efficiency of mitochondrial metabolism. iScience. 2024 Mar 15; 27(3):109078. Voorsluijs V, Avanzini F, Falasco G, Esposito M, Skupin A. PMID: 38375217; PMCID: PMC10875125.
      View in: PubMed   Mentions:
    4. Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts. bioRxiv. 2023 Dec 12. Yabo YA, Moreno-Sanchez PM, Pires-Afonso Y, Kaoma T, Nosirov B, Scafidi A, Ermini L, Lipsa A, Oudin A, Kyriakis D, Grzyb K, Poovathingal SK, Poli A, Muller A, Toth R, Klink B, Berchem G, Berthold C, Hertel F, Mittelbronn M, Heiland DH, Skupin A, Nazarov PV, Niclou SP, Michelucci A, Golebiewska A. PMID: 36945572; PMCID: PMC10028830.
      View in: PubMed   Mentions:
    5. Early-to-mid stage idiopathic Parkinson's disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females. Nat Commun. 2023 Nov 20; 14(1):7461. Capelle CM, Ciré S, Hedin F, Hansen M, Pavelka L, Grzyb K, Kyriakis D, Hunewald O, Konstantinou M, Revets D, Tslaf V, Marques TM, Gomes CPC, Baron A, Domingues O, Gomez M, Zeng N, Betsou F, May P, Skupin A, Cosma A, Balling R, Krüger R, Ollert M, Hefeng FQ. PMID: 37985656; PMCID: PMC10662447.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Mechanistic multiscale modelling of energy metabolism in human astrocytes reveals the impact of morphology changes in Alzheimer's Disease. PLoS Comput Biol. 2023 09; 19(9):e1011464. Farina S, Voorsluijs V, Fixemer S, Bouvier DS, Claus S, Ellisman MH, Bordas SPA, Skupin A. PMID: 37729344; PMCID: PMC10545114.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Formate promotes invasion and metastasis in reliance on lipid metabolism. Cell Rep. 2023 09 26; 42(9):113034. Delbrouck C, Kiweler N, Chen O, Pozdeev VI, Haase L, Neises L, Oudin A, Fouquier d'Hérouël A, Shen R, Schlicker L, Halder R, Lesur A, Schuster A, Lorenz NI, Jaeger C, Feucherolles M, Frache G, Szpakowska M, Chevigne A, Ronellenfitsch MW, Moussay E, Piraud M, Skupin A, Schulze A, Niclou SP, Letellier E, Meiser J. PMID: 37651228.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Seizure-induced increase in microglial cell population in the developing zebrafish brain. Epilepsy Res. 2023 09; 195:107203. Martins TG, Soliman R, Cordero-Maldonado ML, Donato C, Ameli C, Mombaerts L, Skupin A, Peri F, Crawford AD. PMID: 37572541.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response. Cell Rep. 2023 07 25; 42(7):112696. Randic T, Magni S, Philippidou D, Margue C, Grzyb K, Preis JR, Wroblewska JP, Nazarov PV, Mittelbronn M, Frauenknecht KBM, Skupin A, Kreis S. PMID: 37379213.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Systematic analysis and optimization of early warning signals for critical transitions using distribution data. iScience. 2023 Jul 21; 26(7):107156. Proverbio D, Skupin A, Gonçalves J. PMID: 37456849; PMCID: PMC10338236.
      View in: PubMed   Mentions:
    11. Buffering variability in cell regulation motifs close to criticality. Phys Rev E. 2022 Sep; 106(3):L032402. Proverbio D, Montanari AN, Skupin A, Gonçalves J. PMID: 36266798.
      View in: PubMed   Mentions: 1     Fields:    
    12. Single-Cell Transcriptional Profiling and Gene Regulatory Network Modeling in Tg2576 Mice Reveal Gender-Dependent Molecular Features Preceding Alzheimer-Like Pathologies. Mol Neurobiol. 2024 Feb; 61(2):541-566. Ali M, Huarte OU, Heurtaux T, Garcia P, Rodriguez BP, Grzyb K, Halder R, Skupin A, Buttini M, Glaab E. PMID: 35980567; PMCID: PMC10861719.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    13. Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency. Mol Oncol. 2022 09; 16(17):3167-3191. Pires-Afonso Y, Muller A, Grzyb K, Oudin A, Yabo YA, Sousa C, Scafidi A, Poli A, Cosma A, Halder R, Coowar D, Golebiewska A, Skupin A, Niclou SP, Michelucci A. PMID: 35838338; PMCID: PMC9441003.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    14. Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients. Cell Rep Med. 2022 04 19; 3(4):100600. Capelle CM, Ciré S, Domingues O, Ernens I, Hedin F, Fischer A, Snoeck CJ, Ammerlaan W, Konstantinou M, Grzyb K, Skupin A, Carty CL, Hilger C, Gilson G, Celebic A, Wilmes P, Del Sol A, Kaplan IM, Betsou F, Abdelrahman T, Cosma A, Vaillant M, Fagherazzi G, Ollert M, Hefeng FQ. PMID: 35480624; PMCID: PMC8960124.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Generation of two human induced pluripotent stem cell lines from fibroblasts of Parkinson's disease patients carrying the ILE368ASN mutation in PINK1 (LCSBi002) and the R275W mutation in Parkin (LCSBI004). Stem Cell Res. 2022 05; 61:102765. Novak G, Finkbeiner S, Skibinski G, Bernini M, Donato C, Skupin A. PMID: 35378365.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol Commun. 2022 03 16; 10(1):36. Fixemer S, Ameli C, Hammer G, Salamanca L, Uriarte Huarte O, Schwartz C, Gérardy JJ, Mechawar N, Skupin A, Mittelbronn M, Bouvier DS. PMID: 35296366; PMCID: PMC8925098.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Stress hormone signalling inhibits Th1 polarization in a CD4 T-cell-intrinsic manner via mTORC1 and the circadian gene PER1. Immunology. 2022 04; 165(4):428-444. Capelle CM, Chen A, Zeng N, Baron A, Grzyb K, Arns T, Skupin A, Ollert M, Hefeng FQ. PMID: 35143696; PMCID: PMC9426625.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Model-based assessment of COVID-19 epidemic dynamics by wastewater analysis. Sci Total Environ. 2022 Jun 25; 827:154235. Proverbio D, Kemp F, Magni S, Ogorzaly L, Cauchie HM, Gonçalves J, Skupin A, Aalto A. PMID: 35245552; PMCID: PMC8886713.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsPHPublic Health
    19. Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression. Am J Hum Genet. 2022 02 03; 109(2):311-327. Zagare A, Barmpa K, Smajic S, Smits LM, Grzyb K, Grünewald A, Skupin A, Nickels SL, Schwamborn JC. PMID: 35077669; PMCID: PMC8874228.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    20. Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease. Commun Biol. 2022 01 13; 5(1):49. Novak G, Kyriakis D, Grzyb K, Bernini M, Rodius S, Dittmar G, Finkbeiner S, Skupin A. PMID: 35027645; PMCID: PMC8758783.
      View in: PubMed   Mentions: 4  Translation:HumansCells
    21. The benefits, costs and feasibility of a low incidence COVID-19 strategy. Lancet Reg Health Eur. 2022 Feb; 13:100294. Czypionka T, Iftekhar EN, Prainsack B, Priesemann V, Bauer S, Calero Valdez A, Cuschieri S, Glaab E, Grill E, Krutzinna J, Lionis C, Machado H, Martins C, Pavlakis GN, Perc M, Petelos E, Pickersgill M, Skupin A, Schernhammer E, Szczurek E, Tsiodras S, Willeit P, Wilmes P. PMID: 35005678; PMCID: PMC8720492.
      View in: PubMed   Mentions: 9  
    22. Generation of two human induced pluripotent stem cell lines (iPSCs) with mutations of the α-synuclein (SNCA) gene associated with Parkinson's disease; the A53T mutation (LCSBi003) and a triplication of the SNCA gene (LCSBi007). Stem Cell Res. 2021 Dec; 57:102600. Novak G, Finkbeiner S, Skibinski G, Skupin A. PMID: 34826737; PMCID: PMC9124237.
      View in: PubMed   Mentions:    Fields:    
    23. Morphological principles of neuronal mitochondria. J Comp Neurol. 2022 04; 530(6):886-902. Mendelsohn R, Garcia GC, Bartol TM, Lee CT, Khandelwal P, Liu E, Spencer DJ, Husar A, Bushong EA, Phan S, Perkins G, Ellisman MH, Skupin A, Sejnowski TJ, Rangamani P. PMID: 34608995; PMCID: PMC8831469.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    24. The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. Cell Rep. 2021 10 19; 37(3):109864. Walter J, Bolognin S, Poovathingal SK, Magni S, Gérard D, Antony PMA, Nickels SL, Salamanca L, Berger E, Smits LM, Grzyb K, Perfeito R, Hoel F, Qing X, Ohnmacht J, Bertacchi M, Jarazo J, Ignac T, Monzel AS, Gonzalez-Cano L, Krüger R, Sauter T, Studer M, de Almeida LP, Tronstad KJ, Sinkkonen L, Skupin A, Schwamborn JC. PMID: 34686322.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. Generation of two human induced pluripotent stem cell lines from fibroblasts of unrelated Parkinson's patients carrying the G2019S mutation in the LRRK2 gene (LCSBi005, LCSBi006). Stem Cell Res. 2021 Dec; 57:102569. Novak G, Finkbeiner S, Skibinski G, Skupin A. PMID: 34736041.
      View in: PubMed   Mentions: 1     Fields:    
    26. Single-nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell-type-specific gene regulatory variation. Epigenetics Chromatin. 2021 09 09; 14(1):43. Gui Y, Grzyb K, Thomas MH, Ohnmacht J, Garcia P, Buttini M, Skupin A, Sauter T, Sinkkonen L. PMID: 34503558; PMCID: PMC8427957.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    27. Modelling COVID-19 dynamics and potential for herd immunity by vaccination in Austria, Luxembourg and Sweden. J Theor Biol. 2021 12 07; 530:110874. Kemp F, Proverbio D, Aalto A, Mombaerts L, Fouquier d'Hérouël A, Husch A, Ley C, Gonçalves J, Skupin A, Magni S. PMID: 34425136; PMCID: PMC8378986.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsPHPublic Health
    28. COVID-19 crisis management in Luxembourg: Insights from an epidemionomic approach. Econ Hum Biol. 2021 12; 43:101051. Burzynski M, Machado J, Aalto A, Beine M, Goncalves J, Haas T, Kemp F, Magni S, Mombaerts L, Picard P, Proverbio D, Skupin A, Docquier F. PMID: 34411841; PMCID: PMC8628655.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    29. Dynamical SPQEIR model assesses the effectiveness of non-pharmaceutical interventions against COVID-19 epidemic outbreaks. PLoS One. 2021; 16(5):e0252019. Proverbio D, Kemp F, Magni S, Husch A, Aalto A, Mombaerts L, Skupin A, Gonçalves J, Ameijeiras-Alonso J, Ley C. PMID: 34019589; PMCID: PMC8139462.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    30. The Contribution of Microglia to Neuroinflammation in Parkinson's Disease. Int J Mol Sci. 2021 Apr 28; 22(9). Badanjak K, Fixemer S, Smajic S, Skupin A, Grünewald A. PMID: 33925154; PMCID: PMC8125756.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    31. Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway. Front Immunol. 2021; 12:639613. Uriarte Huarte O, Kyriakis D, Heurtaux T, Pires-Afonso Y, Grzyb K, Halder R, Buttini M, Skupin A, Mittelbronn M, Michelucci A. PMID: 33854507; PMCID: PMC8039119.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    32. SARS-CoV-2 transmission risk from asymptomatic carriers: Results from a mass screening programme in Luxembourg. Lancet Reg Health Eur. 2021 May; 4:100056. Wilmes P, Zimmer J, Schulz J, Glod F, Veiber L, Mombaerts L, Rodrigues B, Aalto A, Pastore J, Snoeck CJ, Ollert M, Fagherazzi G, Mossong J, Goncalves J, Skupin A, Nehrbass U. PMID: 33997830; PMCID: PMC7912359.
      View in: PubMed   Mentions: 45  
    33. l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain. Front Genet. 2020; 11:612343. Soliman R, Cordero-Maldonado ML, Martins TG, Moein M, Conrotte JF, Warmack RA, Skupin A, Crawford AD, Clarke SG, Linster CL. PMID: 33552132; PMCID: PMC7859441.
      View in: PubMed   Mentions: 2  
    34. Roles of bacteriophages, plasmids and CRISPR immunity in microbial community dynamics revealed using time-series integrated meta-omics. Nat Microbiol. 2021 01; 6(1):123-135. Martínez Arbas S, Narayanasamy S, Herold M, Lebrun LA, Hoopmann MR, Li S, Lam TJ, Kunath BJ, Hicks ND, Liu CM, Price LB, Laczny CC, Gillece JD, Schupp JM, Keim PS, Moritz RL, Faust K, Tang H, Ye Y, Skupin A, May P, Muller EEL, Wilmes P. PMID: 33139880; PMCID: PMC7752763.
      View in: PubMed   Mentions: 21     Fields:    Translation:CellsPHPublic Health
    35. ROS networks: designs, aging, Parkinson's disease and precision therapies. NPJ Syst Biol Appl. 2020 10 26; 6(1):34. N Kolodkin A, Sharma RP, Colangelo AM, Ignatenko A, Martorana F, Jennen D, Briedé JJ, Brady N, Barberis M, Mondeel TDGA, Papa M, Kumar V, Peters B, Skupin A, Alberghina L, Balling R, Westerhoff HV. PMID: 33106503; PMCID: PMC7589522.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    36. Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathol. 2020 12; 140(6):919-949. Golebiewska A, Hau AC, Oudin A, Stieber D, Yabo YA, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov PV, Azuaje F, De Falco A, Flies B, Richart L, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Malta TM, Noushmehr H, Kwon YJ, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R, Niclou SP. PMID: 33009951; PMCID: PMC7666297.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    37. Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Cell Tissue Res. 2020 Dec; 382(3):463-476. Smits LM, Magni S, Kinugawa K, Grzyb K, Luginbühl J, Sabate-Soler S, Bolognin S, Shin JW, Mori E, Skupin A, Schwamborn JC. PMID: 32737576; PMCID: PMC7683480.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    38. New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome. Epilepsia. 2020 03; 61(3):549-560. Tiraboschi E, Martina S, van der Ent W, Grzyb K, Gawel K, Cordero-Maldonado ML, Poovathingal SK, Heintz S, Satheesh SV, Brattespe J, Xu J, Suster M, Skupin A, Esguerra CV. PMID: 32096222.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    39. A Statistical View on Calcium Oscillations. Adv Exp Med Biol. 2020; 1131:799-826. Powell J, Falcke M, Skupin A, Bellamy TC, Kypraios T, Thul R. PMID: 31646535.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies. BMC Mol Cell Biol. 2019 Dec 19; 20(1):59. Intosalmi J, Scott AC, Hays M, Flann N, Yli-Harja O, Lähdesmäki H, Dudley AM, Skupin A. PMID: 31856706; PMCID: PMC6923950.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    41. Mitochondrial morphology provides a mechanism for energy buffering at synapses. Sci Rep. 2019 12 04; 9(1):18306. Garcia GC, Bartol TM, Phan S, Bushong EA, Perkins G, Sejnowski TJ, Ellisman MH, Skupin A. PMID: 31797946; PMCID: PMC6893035.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    42. Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease. Antioxid Redox Signal. 2019 12 01; 31(16):1213-1234. Grossmann D, Berenguer-Escuder C, Bellet ME, Scheibner D, Bohler J, Massart F, Rapaport D, Skupin A, Fouquier d'Hérouël A, Sharma M, Ghelfi J, Rakovic A, Lichtner P, Antony P, Glaab E, May P, Dimmer KS, Fitzgerald JC, Grünewald A, Krüger R. PMID: 31303019; PMCID: PMC6798875.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    43. Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment. Nat Commun. 2019 04 16; 10(1):1787. Dirkse A, Golebiewska A, Buder T, Nazarov PV, Muller A, Poovathingal S, Brons NHC, Leite S, Sauvageot N, Sarkisjan D, Seyfrid M, Fritah S, Stieber D, Michelucci A, Hertel F, Herold-Mende C, Azuaje F, Skupin A, Bjerkvig R, Deutsch A, Voss-Böhme A, Niclou SP. PMID: 30992437; PMCID: PMC6467886.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansAnimalsCells
    44. MIC-MAC: An automated pipeline for high-throughput characterization and classification of three-dimensional microglia morphologies in mouse and human postmortem brain samples. Glia. 2019 08; 67(8):1496-1509. Salamanca L, Mechawar N, Murai KK, Balling R, Bouvier DS, Skupin A. PMID: 30983036; PMCID: PMC6617786.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    45. Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality. Stem Cell Reports. 2019 05 14; 12(5):878-889. Walter J, Bolognin S, Antony PMA, Nickels SL, Poovathingal SK, Salamanca L, Magni S, Perfeito R, Hoel F, Qing X, Jarazo J, Arias-Fuenzalida J, Ignac T, Monzel AS, Gonzalez-Cano L, Pereira de Almeida L, Skupin A, Tronstad KJ, Schwamborn JC. PMID: 30982740; PMCID: PMC6522948.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    46. Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures. EMBO Rep. 2018 11; 19(11). Sousa C, Golebiewska A, Poovathingal SK, Kaoma T, Pires-Afonso Y, Martina S, Coowar D, Azuaje F, Skupin A, Balling R, Biber K, Niclou SP, Michelucci A. PMID: 30206190; PMCID: PMC6216255.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    47. CaSiAn: a Calcium Signaling Analyzer tool. Bioinformatics. 2018 09 01; 34(17):3052-3054. Moein M, Grzyb K, Gonçalves Martins T, Komoto S, Peri F, Crawford AD, Fouquier d'Herouel A, Skupin A. PMID: 29668830; PMCID: PMC6129310.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    48. Data-driven dynamical model indicates that the heat shock response in Chlamydomonas reinhardtii is tailored to handle natural temperature variation. J R Soc Interface. 2018 05; 15(142). Magni S, Succurro A, Skupin A, Ebenhöh O. PMID: 29720454; PMCID: PMC6000179.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    49. Loss of inter-cellular cooperation by complete epithelial-mesenchymal transition supports favorable outcomes in basal breast cancer patients. Oncotarget. 2018 Apr 13; 9(28):20018-20033. Grosse-Wilde A, Kuestner RE, Skelton SM, MacIntosh E, d'Hérouël AF, Ertaylan G, Del Sol A, Skupin A, Huang S. PMID: 29732000; PMCID: PMC5929443.
      View in: PubMed   Mentions: 11     Fields:    
    50. On the phase space structure of IP3 induced Ca2+ signalling and concepts for predictive modeling. Chaos. 2018 Apr; 28(4):045115. Falcke M, Moein M, Tilunaite A, Thul R, Skupin A. PMID: 31906671.
      View in: PubMed   Mentions: 2     Fields:    
    51. Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1-/- zebrafish. Eur J Neurosci. 2017 02; 45(4):528-535. Soman S, Keatinge M, Moein M, Da Costa M, Mortiboys H, Skupin A, Sugunan S, Bazala M, Kuznicki J, Bandmann O. PMID: 27859782; PMCID: PMC5324670.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    52. Cell Fate Decision as High-Dimensional Critical State Transition. PLoS Biol. 2016 Dec; 14(12):e2000640. Mojtahedi M, Skupin A, Zhou J, Castaño IG, Leong-Quong RY, Chang H, Trachana K, Giuliani A, Huang S. PMID: 28027308; PMCID: PMC5189937.
      View in: PubMed   Mentions: 142     Fields:    Translation:Animals
    53. Analysis of mitochondrial metabolism in situ: Combining stable isotope labeling with selective permeabilization. Metab Eng. 2017 09; 43(Pt B):147-155. Nonnenmacher Y, Palorini R, d'Herouël AF, Krämer L, Neumann-Schaal M, Chiaradonna F, Skupin A, Wegner A, Hiller K. PMID: 27988388.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    54. Neurological Diseases from a Systems Medicine Point of View. Methods Mol Biol. 2016; 1386:221-50. Ostaszewski M, Skupin A, Balling R. PMID: 26677186.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    55. Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression. J Biol Chem. 2016 Feb 19; 291(8):3932-46. Meiser J, Krämer L, Sapcariu SC, Battello N, Ghelfi J, D'Herouel AF, Skupin A, Hiller K. PMID: 26679997; PMCID: PMC4759172.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    56. Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity. Neural Plast. 2015; 2015:683490. Komin N, Moein M, Ellisman MH, Skupin A. PMID: 26347125; PMCID: PMC4539483.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    57. Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival. PLoS One. 2015; 10(5):e0126522. Grosse-Wilde A, Fouquier d'Hérouël A, McIntosh E, Ertaylan G, Skupin A, Kuestner RE, del Sol A, Walters KA, Huang S. PMID: 26020648; PMCID: PMC4447403.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    58. Protocols and programs for high-throughput growth and aging phenotyping in yeast. PLoS One. 2015; 10(3):e0119807. Jung PP, Christian N, Kay DP, Skupin A, Linster CL. PMID: 25822370; PMCID: PMC4379057.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    59. Critical transitions in chronic disease: transferring concepts from ecology to systems medicine. Curr Opin Biotechnol. 2015 Aug; 34:48-55. Trefois C, Antony PM, Goncalves J, Skupin A, Balling R. PMID: 25498477.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    60. Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes. Sci Signal. 2014 Jun 24; 7(331):ra59. Thurley K, Tovey SC, Moenke G, Prince VL, Meena A, Thomas AP, Skupin A, Taylor CW, Falcke M. PMID: 24962706; PMCID: PMC4092318.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    61. Unidirectional P-body transport during the yeast cell cycle. PLoS One. 2014; 9(6):e99428. Garmendia-Torres C, Skupin A, Michael SA, Ruusuvuori P, Kuwada NJ, Falconnet D, Cary GA, Hansen C, Wiggins PA, Dudley AM. PMID: 24918601; PMCID: PMC4053424.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    62. Discovering pair-wise genetic interactions: an information theory-based approach. PLoS One. 2014; 9(3):e92310. Ignac TM, Skupin A, Sakhanenko NA, Galas DJ. PMID: 24670935; PMCID: PMC3966778.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    63. Describing the complexity of systems: multivariable "set complexity" and the information basis of systems biology. J Comput Biol. 2014 Feb; 21(2):118-40. Galas DJ, Sakhanenko NA, Skupin A, Ignac T. PMID: 24377753; PMCID: PMC3904535.
      View in: PubMed   Mentions: 15     Fields:    
    64. Mesoscopic behavior from microscopic Markov dynamics and its application to calcium release channels. J Theor Biol. 2014 Feb 21; 343:102-12. Christian N, Skupin A, Morante S, Jansen K, Rossi G, Ebenhöh O. PMID: 24270093.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    65. Aneuploidy underlies a multicellular phenotypic switch. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12367-72. Tan Z, Hays M, Cromie GA, Jeffery EW, Scott AC, Ahyong V, Sirr A, Skupin A, Dudley AM. PMID: 23812752; PMCID: PMC3725063.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    66. Calcium signaling: from single channels to pathways. Adv Exp Med Biol. 2012; 740:531-51. Skupin A, Thurley K. PMID: 22453959.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    67. Carbohydrate-active enzymes exemplify entropic principles in metabolism. Mol Syst Biol. 2011 Oct 25; 7:542. Kartal O, Mahlow S, Skupin A, Ebenhöh O. PMID: 22027553; PMCID: PMC3261701.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    68. Fundamental properties of Ca2+ signals. Biochim Biophys Acta. 2012 Aug; 1820(8):1185-94. Thurley K, Skupin A, Thul R, Falcke M. PMID: 22040723.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    69. Modeling the complex dynamics of enzyme-pathway coevolution. Chaos. 2010 Dec; 20(4):045115. Schütte M, Skupin A, Segrè D, Ebenhöh O. PMID: 21198127.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    70. Calcium signals driven by single channel noise. PLoS Comput Biol. 2010 Aug 05; 6(8). Skupin A, Kettenmann H, Falcke M. PMID: 20700497; PMCID: PMC2917103.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    71. From puffs to global Ca2+ signals: how molecular properties shape global signals. Chaos. 2009 Sep; 19(3):037111. Skupin A, Falcke M. PMID: 19792036.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    72. Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+. Nature. 2009 Apr 02; 458(7238):655-9. Skupin A, Falcke M, Taylor CW. PMID: 19348050; PMCID: PMC2702691.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    73. The role of IP3R clustering in Ca2+ signalinG. Genome Inform. 2008; 20:15-24. Skupin A, Falcke M. PMID: 19425119.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    74. How does intracellular Ca2+ oscillate: by chance or by the clock? Biophys J. 2008 Mar 15; 94(6):2404-11. Skupin A, Kettenmann H, Winkler U, Wartenberg M, Sauer H, Tovey SC, Taylor CW, Falcke M. PMID: 18065468; PMCID: PMC2257893.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    75. Temperature and nitric oxide control spontaneous calcium transients in astrocytes. Cell Calcium. 2008 Mar; 43(3):285-95. Schipke CG, Heidemann A, Skupin A, Peters O, Falcke M, Kettenmann H. PMID: 17698190.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    76. Statistical properties and information content of calcium oscillations. Genome Inform. 2007; 18:44-53. Skupin A, Falcke M. PMID: 18546473.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
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