Francisco Villarreal

Title(s)Recall Faculty, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Excess O-GlcNAc modification of proteins and myocardial fibrosis
    NIH I01BX003230Jan 1, 2018 - Dec 31, 2021
    Role: Principal Investigator
    Epicatechin Treatment for Sarcopenia
    NIH R56AG052593Sep 30, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Epicatechin treatment for sarcopenia
    NIH R21AG047326Sep 15, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Epicatechin and derivatives to preserve muscle structure function in diabetes
    NIH R01DK098717Mar 10, 2014 - Dec 31, 2018
    Role: Principal Investigator
    Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin
    NIH R01AT008310Sep 1, 2013 - Aug 31, 2016
    Role: Principal Investigator
    Targeting cellular bioenergetics for the prevention and treatment of diabetes
    NIH R24DK092154Aug 1, 2011 - Jul 31, 2013
    Role: Principal Investigator
    Effects of Cocoa Flavonols on Myocardial Infarction Size and Post-Injury Injury
    NIH R21AT004277Sep 30, 2008 - Jul 31, 2011
    Role: Principal Investigator
    26th Annual Meeting of the North Am. Section of the ISHR
    NIH R13HL078318Jul 1, 2004 - Jun 30, 2005
    Role: Principal Investigator
    San Diego IRACDA Scholars Program
    NIH K12GM068524Aug 1, 2003 - Jun 30, 2026
    Role: Principal Investigator
    Adenosine Mediated Modulation of Cardiac Fibrosis
    NIH R01HL067922Jul 15, 2002 - Jun 30, 2008
    Role: Principal Investigator
    HEART FIBROBLAST AND COLLAGEN TYPE III REGULATION
    NIH K14HL003160Jul 1, 1994 - Jun 30, 2000
    Role: Principal Investigator
    Molecular biology and mechanics of the cardiac interstitium
    NIH R01HL043617Jul 1, 1989 - Mar 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Restorative effects of (+)-epicatechin in a rodent model of aging induced muscle atrophy: underlying mechanisms. Food Funct. 2024 Apr 02; 15(7):3669-3679. Ramirez-Sanchez I, Navarrete-Yañez V, Ramirez L, Galera L, Mendez-Bolaina E, Najera V, Ceballos G, Villarreal F. PMID: 38487922.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Improving Cardiovascular Risk in Postmenopausal Women with an (-)-Epicatechin-Based Nutraceutical: A Randomly Assigned, Double-Blind vs. Placebo, Proof-of-Concept Trial. J Clin Med. 2023 Dec 29; 13(1). Nájera N, Ortíz-Flores M, Pérez-Durán J, Reyes-Muñoz E, Romo-Yañez J, Ortiz-Luna G, Villarreal F, Meaney E, Ceballos G, Montoya-Estrada A. PMID: 38202201; PMCID: PMC10779966.
      View in: PubMed   Mentions:
    3. Effects of aging and type 2 diabetes on cardiac structure and function: Underlying mechanisms. Exp Gerontol. 2023 03; 173:112108. Nguyen JP, Ramirez-Sanchez I, Garate-Carrillo A, Navarrete-Yañez V, Carballo-Castañeda RA, Ceballos G, Moreno-Ulloa A, Villarreal F. PMID: 36708752.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Correlation of Biomarkers of Endothelial Injury and Inflammation to Outcome in Hospitalized COVID-19 Patients. J Clin Med. 2022 Dec 15; 11(24). Munguía L, Nájera N, Martínez FJ, Díaz-Chiguer D, Jiménez-Ponce F, Ortiz-Flores M, Villarreal F, Ceballos G. PMID: 36556051.
      View in: PubMed   Mentions: 5  
    5. (-)-Epicatechin Is a Biased Ligand of Apelin Receptor. Int J Mol Sci. 2022 Aug 11; 23(16). Portilla-Martínez A, Ortiz-Flores MÁ, Meaney E, Villarreal F, Nájera N, Ceballos G. PMID: 36012227; PMCID: PMC9409145.
      View in: PubMed   Mentions: 1     Fields:    
    6. (-)-Epicatechin Ameliorates Cardiac Fibrosis in a Female Rat Model of Pre-Heart Failure with Preserved Ejection Fraction. J Med Food. 2022 Aug; 25(8):836-844. Bustamante-Pozo M, Ramirez-Sanchez I, Garate-Carrillo A, Ito B, Navarrete V, Haro M, Garcia R, Carson N, Ceballos G, Villarreal F. PMID: 35917528; PMCID: PMC9419952.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Multi-omics study identifies novel signatures of DNA/RNA, amino acid, peptide, and lipid metabolism by simulated diabetes on coronary endothelial cells. Sci Rep. 2022 07 14; 12(1):12027. Moreno-Ulloa A, Delgado-De la Herrán HC, Álvarez-Delgado C, Mendoza-Porras O, Carballo-Castañeda RA, Donis-Maturano L, Villarreal F. PMID: 35835939; PMCID: PMC9283518.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Beneficial Effects of Flavonoids on Skeletal Muscle Health: A Systematic Review and Meta-Analysis. J Med Food. 2022 May; 25(5):465-486. Munguía L, Ortiz M, González C, Portilla A, Meaney E, Villarreal F, Nájera N, Ceballos G. PMID: 35394826.
      View in: PubMed   Mentions: 4     Fields:    
    9. Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data. J Basic Clin Physiol Pharmacol. 2022 Nov 01; 33(6):703-714. Hidalgo I, Ortiz-Flores M, Villarreal F, Fonseca-Coronado S, Ceballos G, Meaney E, Nájera N. PMID: 35119232.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Anticancer potential of (-)-epicatechin in a triple-negative mammary gland model. J Pharm Pharmacol. 2021 Dec 07; 73(12):1675-1682. Almaguer G, Ortiz-Vilchis P, Cordero P, Martinez-Vega R, Perez-Durán J, Meaney E, Villarreal F, Ceballos G, Nájera N. PMID: 34473289; PMCID: PMC8651247.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Restorative potential of (-)-epicatechin in a rat model of Gulf War illness muscle atrophy and fatigue. Sci Rep. 2021 11 08; 11(1):21861. Ramirez-Sanchez I, Navarrete-Yañez V, Garate-Carrillo A, Lara-Hernandez M, Espinosa-Raya J, Moreno-Ulloa A, Gomez-Diaz B, Cedeño-Garcidueñas AL, Ceballos G, Villarreal F. PMID: 34750405; PMCID: PMC8575952.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    12. Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction. JACC Basic Transl Sci. 2021 Aug; 6(8):676-689. García RA, Lupisella JA, Ito BR, Hsu MY, Fernando G, Carson NL, Allocco JJ, Ryan CS, Zhang R, Wang Z, Heroux M, Carrier M, St-Onge S, Bouvier M, Dudhgaonkar S, Nagar J, Bustamante-Pozo MM, Garate-Carrillo A, Chen J, Ma X, Search DJ, Dierks EA, Kick EK, Wexler RR, Gordon DA, Ostrowski J, Wurtz NR, Villarreal F. PMID: 34466754; PMCID: PMC8385569.
      View in: PubMed   Mentions: 17  
    13. Antifibrotic Effects of (-)-Epicatechin on High Glucose Stimulated Cardiac Fibroblasts. J Med Food. 2021 Nov; 24(11):1177-1185. Garate-Carrillo A, Ramirez-Sanchez I, Nguyen J, Gonzalez J, Ceballos G, Villarreal F. PMID: 34227843.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Stimulatory effects of (-)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept. Food Funct. 2021 Apr 26; 12(8):3504-3515. Navarrete-Yañez V, Garate-Carrillo A, Ayala M, Rodriguez-Castañeda A, Mendoza-Lorenzo P, Ceballos G, Ordoñez-Razo R, Dugar S, Schreiner G, Villarreal F, Ramirez-Sanchez I. PMID: 33900336.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. (-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy. Muscle Nerve. 2021 02; 63(2):239-249. McDonald CM, Ramirez-Sanchez I, Oskarsson B, Joyce N, Aguilar C, Nicorici A, Dayan J, Goude E, Abresch RT, Villarreal F, Ceballos G, Perkins G, Dugar S, Schreiner G, Henricson EK. PMID: 33125736; PMCID: PMC7898288.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    16. Effects of (-)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice. Food Funct. 2020 Dec 01; 11(12):10351-10361. Navarrete-Yañez V, Garate-Carrillo A, Rodriguez A, Mendoza-Lorenzo P, Ceballos G, Calzada-Mendoza C, Hogan MC, Villarreal F, Ramirez-Sanchez I. PMID: 33201160; PMCID: PMC7746633.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    17. (-)-Epicatechin reduces muscle waste after complete spinal cord transection in a murine model: role of ubiquitin-proteasome system. Mol Biol Rep. 2020 Nov; 47(11):8975-8985. Gonzalez-Ruiz C, Cordero-Anguiano P, Morales-Guadarrama A, Mondragón-Lozano R, Sánchez-Torres S, Salgado-Ceballos H, Villarreal F, Meaney E, Ceballos G, Nájera N. PMID: 33151476.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. PXR is a target of (-)-epicatechin in skeletal muscle. Heliyon. 2020 Oct; 6(10):e05357. Ortiz-Flores M, Portilla-Martínez A, Cabrera-Pérez F, Nájera N, Meaney E, Villarreal F, Pérez-Durán J, Ceballos G. PMID: 33163657; PMCID: PMC7610271.
      View in: PubMed   Mentions: 8  
    19. In Pursuit of Understanding the Role of Estrogens in Regulating Cardiac Structure and Function. JACC Basic Transl Sci. 2020 Sep; 5(9):913-915. Villarreal F. PMID: 33016955; PMCID: PMC7524778.
      View in: PubMed   Mentions: 1  
    20. Development of muscle atrophy and loss of function in a Gulf-War illness model: underlying mechanisms. Sci Rep. 2020 09 03; 10(1):14526. Ramirez-Sanchez I, Navarrete-Yañez V, Garate-Carrillo A, Loredo M, Lira-Romero E, Estrada-Mena J, Campeau A, Gonzalez D, Carrillo-Terrazas M, Moreno-Ulloa A, Ceballos G, Villarreal F. PMID: 32884027; PMCID: PMC7471336.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. Arginase inhibition by (-)-Epicatechin reverses endothelial cell aging. Eur J Pharmacol. 2020 Oct 15; 885:173442. Garate-Carrillo A, Navarrete-Yañez V, Ortiz-Vilchis P, Guevara G, Castillo C, Mendoza-Lorenzo P, Ceballos G, Ortiz-Flores M, Najera N, Bustamante-Pozo MM, Rubio-Gayosso I, Villarreal F, Ramirez-Sanchez I. PMID: 32795514; PMCID: PMC7418791.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    22. Flavonoids from dark chocolate and (-)-epicatechin ameliorate high-fat diet-induced decreases in mobility and muscle damage in aging mice. Food Biosci. 2020 Oct; 37. Munguia L, Ramirez-Sanchez I, Meaney E, Villarreal F, Ceballos G, Najera N. PMID: 32953444; PMCID: PMC7497789.
      View in: PubMed   Mentions: 6  
    23. Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure. J Med Chem. 2020 09 10; 63(17):9003-9019. Asahina Y, Wurtz NR, Arakawa K, Carson N, Fujii K, Fukuchi K, Garcia R, Hsu MY, Ishiyama J, Ito B, Kick E, Lupisella J, Matsushima S, Ohata K, Ostrowski J, Saito Y, Tsuda K, Villarreal F, Yamada H, Yamaoka T, Wexler R, Gordon D, Kohno Y. PMID: 32407089.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    24. Effects of Cacao By-Products and a Modest Weight Loss Intervention on the Concentration of Serum Triglycerides in Overweight Subjects: Proof of Concept. J Med Food. 2020 Jul; 23(7):745-749. León-Flores P, Nájera N, Pérez E, Pardo B, Jimenez F, Diaz-Chiguer D, Villarreal F, Hidalgo I, Ceballos G, Meaney E. PMID: 32286894; PMCID: PMC7370978.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    25. The role of inflammation in driving left ventricular remodeling in a pre-HFpEF model. Exp Biol Med (Maywood). 2020 04; 245(8):748-757. Loredo-Mendoza ML, Ramirez-Sanchez I, Bustamante-Pozo MM, Ayala M, Navarrete V, Garate-Carrillo A, Ito BR, Ceballos G, Omens J, Villarreal F. PMID: 32183553; PMCID: PMC7221483.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Sex related differences in the pathogenesis of organ fibrosis. Transl Res. 2020 08; 222:41-55. Garate-Carrillo A, Gonzalez J, Ceballos G, Ramirez-Sanchez I, Villarreal F. PMID: 32289256; PMCID: PMC7721117.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    27. Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial. Circ Res. 2020 02 28; 126(5):589-599. McDermott MM, Criqui MH, Domanchuk K, Ferrucci L, Guralnik JM, Kibbe MR, Kosmac K, Kramer CM, Leeuwenburgh C, Li L, Lloyd-Jones D, Peterson CA, Polonsky TS, Stein JH, Sufit R, Van Horn L, Villarreal F, Zhang D, Zhao L, Tian L. PMID: 32078436; PMCID: PMC7141749.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    28. Effects of (-)-epicatechin on the time course of the expression of perilipins in a diet-induced model of nonalcoholic steatohepatitis. J Nutr Biochem. 2020 03; 77:108296. Hidalgo I, Nájera N, Meaney E, Pérez-Durán J, Valdespino-Vazquez Y, Villarreal F, Ceballos G. PMID: 32007822.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    29. Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment. JACC Basic Transl Sci. 2019 Dec; 4(8):905-920. García RA, Ito BR, Lupisella JA, Carson NA, Hsu MY, Fernando G, Heroux M, Bouvier M, Dierks E, Kick EK, Gordon DA, Chen J, Mintier G, Carrier M, St-Onge S, Shah H, Towne J, Bucardo MS, Ma X, Ryan CS, Wurtz NR, Ostrowski J, Villarreal FJ. PMID: 31909300; PMCID: PMC6939031.
      View in: PubMed   Mentions: 15  
    30. 11-β-hydroxysterols as possible endogenous stimulators of mitochondrial biogenesis as inferred from epicatechin molecular mimicry. Pharmacol Res. 2020 01; 151:104540. Dugar S, Villarreal F, Hollinger FH, Mahajan D, Ramirez-Sanchez I, Moreno-Ulloa A, Ceballos G, Schreiner G. PMID: 31722227.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. High Flavonoid Cocoa Supplement Ameliorates Plasma Oxidative Stress and Inflammation Levels While Improving Mobility and Quality of Life in Older Subjects: A Double-Blind Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2019 09 15; 74(10):1620-1627. Munguia L, Rubio-Gayosso I, Ramirez-Sanchez I, Ortiz A, Hidalgo I, Gonzalez C, Meaney E, Villarreal F, Najera N, Ceballos G. PMID: 31056655; PMCID: PMC6748722.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    32. Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. Am J Physiol Regul Integr Comp Physiol. 2019 07 01; 317(1):R160-R168. Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A. PMID: 31091156; PMCID: PMC6692752.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    33. Obesity and Cardiovascular Risk Improvement Using Cacao By-Products in a Diet-Induced Obesity Murine Model. J Med Food. 2019 Jun; 22(6):567-577. Hidalgo I, Ortiz A, Sanchez-Pardo M, Garduño-Siciliano L, Hernández-Ortega M, Villarreal F, Meaney E, Najera N, Ceballos GM. PMID: 31021307.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    34. Effect of (-)-epicatechin on the modulation of progression markers of chronic renal damage in a 5/6 nephrectomy experimental model. Heliyon. 2019 Apr; 5(4):e01512. Montes-Rivera J, Arellano-Mendoza M, Nájera N, Del Valle-Mondragón L, Villarreal F, Rubio-Gayosso I, Perez-Duran J, Meaney E, Ceballos G. PMID: 31025018; PMCID: PMC6475891.
      View in: PubMed   Mentions: 1  
    35. Structural and energetic basis for novel epicatechin derivatives acting as GPER agonists through the MMGBSA method. J Steroid Biochem Mol Biol. 2019 05; 189:176-186. Bello M, Méndez-Luna D, Sarmiento V, Correa Basurto J, Najera N, Villarreal F, Ceballos G. PMID: 30851383.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    36. Unmasking of oestrogen-dependent changes in left ventricular structure and function in aged female rats: a potential model for pre-heart failure with preserved ejection fraction. J Physiol. 2019 04; 597(7):1805-1817. Bustamante M, Garate-Carrillo A, R Ito B, Garcia R, Carson N, Ceballos G, Ramirez-Sanchez I, Omens J, Villarreal F. PMID: 30681142; PMCID: PMC6442018.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    37. Correction to: Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance. Diabetologia. 2018 12; 61(12):2674. Formentini L, Ryan AJ, Gálvez-Santisteban M, Carter L, Taub P, Lapek JD, Gonzalez DJ, Villarreal F, Ciaraldi TP, Cuezva JM, Henry RR. PMID: 30324489.
      View in: PubMed   Mentions:    Fields:    
    38. (-)-Epicatechin induced reversal of endothelial cell aging and improved vascular function: underlying mechanisms. Food Funct. 2018 Sep 19; 9(9):4802-4813. Ramirez-Sanchez I, Mansour C, Navarrete-Yañez V, Ayala-Hernandez M, Guevara G, Castillo C, Loredo M, Bustamante M, Ceballos G, Villarreal FJ. PMID: 30129961; PMCID: PMC6490961.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Synthesis of novel (-)-epicatechin derivatives as potential endothelial GPER agonists: Evaluation of biological effects. Bioorg Med Chem Lett. 2018 02 15; 28(4):658-663. Sarmiento V, Ramirez-Sanchez I, Moreno-Ulloa A, Romero-Perez D, Chávez D, Ortiz M, Najera N, Correa-Basurto J, Villarreal F, Ceballos G. PMID: 29395974; PMCID: PMC5817025.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    40. A pilot study on clinical pharmacokinetics and preclinical pharmacodynamics of (+)-epicatechin on cardiometabolic endpoints. Food Funct. 2018 Jan 24; 9(1):307-319. Moreno-Ulloa A, Nájera-García N, Hernández M, Ramírez-Sánchez I, Taub PR, Su Y, Beltrán-Partida E, Ceballos G, Dugar S, Schreiner G, Best BM, Ciaraldi TP, Henry RR, Villarreal F. PMID: 29171848; PMCID: PMC5783763.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    41. (-)-Epicatechin stimulates mitochondrial biogenesis and cell growth in C2C12 myotubes via the G-protein coupled estrogen receptor. Eur J Pharmacol. 2018 Mar 05; 822:95-107. Moreno-Ulloa A, Miranda-Cervantes A, Licea-Navarro A, Mansour C, Beltrán-Partida E, Donis-Maturano L, Delgado De la Herrán HC, Villarreal F, Álvarez-Delgado C. PMID: 29355558; PMCID: PMC5809192.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    42. The cardioprotective effects of (-)-Epicatechin are mediated through arginase activity inhibition in a murine model of ischemia/reperfusion. Eur J Pharmacol. 2018 Jan 05; 818:335-342. Ortiz-Vilchis P, Ortiz-Flores M, Pacheco M, Ramirez-Sanchez I, Moreno-Ulloa A, Vega L, Ortiz A, Villarreal F, Rubio-Gayosso I, Najera N, Meaney E, Ceballos G. PMID: 29126791.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    43. Effects of (-)-epicatechin on frontal cortex DAPC and dysbindin of the mdx mice. Neurosci Lett. 2017 Sep 29; 658:142-149. Estrada-Mena FJ, Rodriguez A, Mendoza-Lorenzo P, Neri-Gomez T, Manjarrez-Gutierrez G, Perez-Ortiz AC, Ordonez-Razo R, Ceballos G, Villarreal F, Ramirez-Sanchez I. PMID: 28855126.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    44. Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance. Diabetologia. 2017 10; 60(10):2052-2065. Formentini L, Ryan AJ, Gálvez-Santisteban M, Carter L, Taub P, Lapek JD, Gonzalez DJ, Villarreal F, Ciaraldi TP, Cuezva JM, Henry RR. PMID: 28770317; PMCID: PMC6572787.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    45. Browning effects of (-)-epicatechin on adipocytes and white adipose tissue. Eur J Pharmacol. 2017 Sep 15; 811:48-59. Varela CE, Rodriguez A, Romero-Valdovinos M, Mendoza-Lorenzo P, Mansour C, Ceballos G, Villarreal F, Ramirez-Sanchez I. PMID: 28576408.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    46. Improved in vitro angiogenic behavior on anodized titanium dioxide nanotubes. J Nanobiotechnology. 2017 Jan 31; 15(1):10. Beltrán-Partida E, Valdéz-Salas B, Moreno-Ulloa A, Escamilla A, Curiel MA, Rosales-Ibáñez R, Villarreal F, Bastidas DM, Bastidas JM. PMID: 28143540; PMCID: PMC5282661.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    47. A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects. Int J Cardiol. 2016 Nov 15; 223:500-506. Gutiérrez-Salmeán G, Meaney E, Lanaspa MA, Cicerchi C, Johnson RJ, Dugar S, Taub P, Ramírez-Sánchez I, Villarreal F, Schreiner G, Ceballos G. PMID: 27552564.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    48. Beneficial effects of dark chocolate on exercise capacity in sedentary subjects: underlying mechanisms. A double blind, randomized, placebo controlled trial. Food Funct. 2016 Sep 14; 7(9):3686-93. Taub PR, Ramirez-Sanchez I, Patel M, Higginbotham E, Moreno-Ulloa A, Román-Pintos LM, Phillips P, Perkins G, Ceballos G, Villarreal F. PMID: 27491778; PMCID: PMC5025384.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    49. (-)-Epicatechin-induced recovery of mitochondria from simulated diabetes: Potential role of endothelial nitric oxide synthase. Diab Vasc Dis Res. 2016 05; 13(3):201-10. Ramírez-Sánchez I, Rodríguez A, Moreno-Ulloa A, Ceballos G, Villarreal F. PMID: 26993496; PMCID: PMC5107246.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    50. Effects of a natural extract of Aronia Melanocarpa berry on endothelial cell nitric oxide production. J Food Biochem. 2016 Aug; 40(4):404-410. Varela CE, Fromentin E, Roller M, Villarreal F, Ramirez-Sanchez I. PMID: 27616799; PMCID: PMC5015692.
      View in: PubMed   Mentions: 3     Fields:    
    51. The effects of (-)-epicatechin on endothelial cells involve the G protein-coupled estrogen receptor (GPER). Pharmacol Res. 2015 Oct; 100:309-20. Moreno-Ulloa A, Mendez-Luna D, Beltran-Partida E, Castillo C, Guevara G, Ramirez-Sanchez I, Correa-Basurto J, Ceballos G, Villarreal F. PMID: 26303816; PMCID: PMC4555879.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    52. Improved Osteoblast and Chondrocyte Adhesion and Viability by Surface-Modified Ti6Al4V Alloy with Anodized TiO₂ Nanotubes Using a Super-Oxidative Solution. Materials (Basel). 2015 Mar 02; 8(3):867-883. Beltrán-Partida E, Moreno-Ulloa A, Valdez-Salas B, Velasquillo C, Carrillo M, Escamilla A, Valdez E, Villarreal F. PMID: 28787976; PMCID: PMC5455429.
      View in: PubMed   Mentions: 11  
    53. Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers. Food Funct. 2015 Mar; 6(3):824-33. Barnett CF, Moreno-Ulloa A, Shiva S, Ramirez-Sanchez I, Taub PR, Su Y, Ceballos G, Dugar S, Schreiner G, Villarreal F. PMID: 25598082; PMCID: PMC4357542.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsCTClinical Trials
    54. (-)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic δ-sarcoglycan null mouse striated muscle. FEBS J. 2014 Dec; 281(24):5567-80. Ramirez-Sanchez I, De los Santos S, Gonzalez-Basurto S, Canto P, Mendoza-Lorenzo P, Palma-Flores C, Ceballos-Reyes G, Villarreal F, Zentella-Dehesa A, Coral-Vazquez R. PMID: 25284161; PMCID: PMC4262719.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    55. Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduces infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling. Eur J Pharmacol. 2014 Dec 05; 744:76-82. Ortiz-Vilchis P, Yamazaki KG, Rubio-Gayosso I, Ramirez-Sanchez I, Calzada C, Romero-Perez D, Ortiz A, Meaney E, Taub P, Villarreal F, Ceballos G. PMID: 25281837; PMCID: PMC5109834.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    56. Myocardial matrix metalloproteinase-2: inside out and upside down. J Mol Cell Cardiol. 2014 Dec; 77:64-72. DeCoux A, Lindsey ML, Villarreal F, Garcia RA, Schulz R. PMID: 25261607; PMCID: PMC4312173.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    57. Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (-)-Epicatechin in Senile Mice. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1370-8. Moreno-Ulloa A, Nogueira L, Rodriguez A, Barboza J, Hogan MC, Ceballos G, Villarreal F, Ramirez-Sanchez I. PMID: 25143004; PMCID: PMC4715241.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    58. Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol. 2014 Aug 01; 175(2):297-306. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN. PMID: 24908200; PMCID: PMC4506135.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    59. Targeting matrix metalloproteinases in heart disease: lessons from endogenous inhibitors. Biochem Pharmacol. 2014 Jul 01; 90(1):7-15. Spinale FG, Villarreal F. PMID: 24780447; PMCID: PMC4060262.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    60. Cell membrane mediated (-)-epicatechin effects on upstream endothelial cell signaling: evidence for a surface receptor. Bioorg Med Chem Lett. 2014 Jun 15; 24(12):2749-52. Moreno-Ulloa A, Romero-Perez D, Villarreal F, Ceballos G, Ramirez-Sanchez I. PMID: 24794111; PMCID: PMC4157920.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    61. Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects. Food Funct. 2014 Mar; 5(3):521-7. Gutiérrez-Salmeán G, Ortiz-Vilchis P, Vacaseydel CM, Rubio-Gayosso I, Meaney E, Villarreal F, Ramírez-Sánchez I, Ceballos G. PMID: 24458104; PMCID: PMC3947792.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCellsCTClinical Trials
    62. Dynamic changes in myocardial matrix and relevance to disease: translational perspectives. Circ Res. 2014 Feb 28; 114(5):916-27. Li AH, Liu PP, Villarreal FJ, Garcia RA. PMID: 24577970.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    63. Role for high-glucose-induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C794-804. Aguilar H, Fricovsky E, Ihm S, Schimke M, Maya-Ramos L, Aroonsakool N, Ceballos G, Dillmann W, Villarreal F, Ramirez-Sanchez I. PMID: 24553187; PMCID: PMC4010805.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    64. Effects of (-)-epicatechin on a diet-induced rat model of cardiometabolic risk factors. Eur J Pharmacol. 2014 Apr 05; 728:24-30. Gutiérrez-Salmeán G, Ortiz-Vilchis P, Vacaseydel CM, Garduño-Siciliano L, Chamorro-Cevallos G, Meaney E, Villafaña S, Villarreal F, Ceballos G, Ramírez-Sánchez I. PMID: 24491839.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    65. Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem. 2014 Jan; 25(1):91-4. Gutierrez-Salmean G, Ciaraldi TP, Nogueira L, Barboza J, Taub PR, Hogan MC, Henry RR, Meaney E, Villarreal F, Ceballos G, Ramirez-Sanchez I. PMID: 24314870; PMCID: PMC3857584.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    66. Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa. Clin Sci (Lond). 2013 Oct; 125(8):383-9. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Gonzalez-Basurto S, Coral-Vazquez R, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. PMID: 23642227.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    67. (-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. Int J Cardiol. 2013 Oct 09; 168(4):3982-3990. Ramirez-Sanchez I, Taub PR, Ciaraldi TP, Nogueira L, Coe T, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. PMID: 23870648; PMCID: PMC3805662.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCTClinical Trials
    68. Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins. Bioorg Med Chem Lett. 2013 Aug 01; 23(15):4441-6. Moreno-Ulloa A, Cid A, Rubio-Gayosso I, Ceballos G, Villarreal F, Ramirez-Sanchez I. PMID: 23791569; PMCID: PMC3741049.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    69. Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise. J Cardiovasc Pharmacol. 2012 Nov; 60(5):429-38. Ramirez-Sanchez I, Nogueira L, Moreno A, Murphy A, Taub P, Perkins G, Ceballos GM, Hogan M, Malek M, Villarreal F. PMID: 22833114; PMCID: PMC3496054.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    70. Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes. J Inflamm (Lond). 2012 Oct 01; 9(1):35. Frankwich K, Tibble C, Torres-Gonzalez M, Bonner M, Lefkowitz R, Tyndall M, Schmid-Schönbein GW, Villarreal F, Heller M, Herbst K. PMID: 23025537; PMCID: PMC3507843.
      View in: PubMed   Mentions: 13  
    71. Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy. Am J Physiol Renal Physiol. 2012 Nov 01; 303(9):F1264-74. Tanabe K, Tamura Y, Lanaspa MA, Miyazaki M, Suzuki N, Sato W, Maeshima Y, Schreiner GF, Villarreal FJ, Johnson RJ, Nakagawa T. PMID: 22933302; PMCID: PMC5243204.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    72. Excess protein O-GlcNAcylation and the progression of diabetic cardiomyopathy. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 01; 303(7):R689-99. Fricovsky ES, Suarez J, Ihm SH, Scott BT, Suarez-Ramirez JA, Banerjee I, Torres-Gonzalez M, Wang H, Ellrott I, Maya-Ramos L, Villarreal F, Dillmann WH. PMID: 22874425; PMCID: PMC3469670.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    73. (-)-Epicatechin-induced calcium independent eNOS activation: roles of HSP90 and AKT. Mol Cell Biochem. 2012 Nov; 370(1-2):141-50. Ramirez-Sanchez I, Aguilar H, Ceballos G, Villarreal F. PMID: 22865466; PMCID: PMC3812804.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    74. Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing. Am J Physiol Heart Circ Physiol. 2012 Apr 01; 302(7):H1387-93. Yamazaki KG, Ihm SH, Thomas RL, Roth D, Villarreal F. PMID: 22268115; PMCID: PMC3330786.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    75. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012 Feb; 5(1):43-7. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. PMID: 22376256; PMCID: PMC5439909.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    76. The beneficial vascular effects of cacao flavanols: having your cake and eating it too. J Appl Physiol (1985). 2011 Dec; 111(6):1544-5. Ceballos G, Villarreal F. PMID: 21998263.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    77. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15; 589(Pt 18):4615-31. Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan MC, Malek MH. PMID: 21788351; PMCID: PMC3208228.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    78. Ventricular pacing-induced loss of contractile function and development of epicardial inflammation. Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1282-90. Yamazaki KG, Villarreal FJ. PMID: 21297025; PMCID: PMC3075045.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    79. (-)-Epicatechin induces calcium and translocation independent eNOS activation in arterial endothelial cells. Am J Physiol Cell Physiol. 2011 Apr; 300(4):C880-7. Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. PMID: 21209365; PMCID: PMC3074631.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    80. Fluorescent detection of (-)-epicatechin in microsamples from cacao seeds and cocoa products: Comparison with Folin-Ciocalteu method. J Food Compost Anal. 2010 Dec 01; 23(8):790-793. Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. PMID: 21297935; PMCID: PMC3032538.
      View in: PubMed   Mentions: 4  
    81. Protein quality control in heart disease: using established drugs to target novel mechanisms. J Am Coll Cardiol. 2010 Oct 19; 56(17):1427-9. Villarreal F, Lew WY. PMID: 20947001; PMCID: PMC2995305.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    82. Tetracycline compounds with non-antimicrobial organ protective properties: possible mechanisms of action. Pharmacol Res. 2011 Feb; 63(2):102-7. Griffin MO, Ceballos G, Villarreal FJ. PMID: 20951211; PMCID: PMC3031662.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    83. Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C539-48. Griffin MO, Fricovsky E, Ceballos G, Villarreal F. PMID: 20592239; PMCID: PMC2944325.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimals
    84. Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion. J Am Coll Cardiol. 2010 Jun 22; 55(25):2869-76. Yamazaki KG, Taub PR, Barraza-Hidalgo M, Rivas MM, Zambon AC, Ceballos G, Villarreal FJ. PMID: 20579545; PMCID: PMC2915587.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    85. (-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension. 2010 Jun; 55(6):1398-405. Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. PMID: 20404222; PMCID: PMC2874202.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    86. Diagnostic approaches for diabetic cardiomyopathy and myocardial fibrosis. J Mol Cell Cardiol. 2010 Mar; 48(3):524-9. Maya L, Villarreal FJ. PMID: 19595694; PMCID: PMC2824060.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    87. Effects of novel semiselective matrix metalloproteinase inhibitors on ex vivo cardiac structure-function. J Cardiovasc Pharmacol. 2009 Jun; 53(6):452-61. Romero-Perez D, Agrawal A, Jacobsen J, Yan Y, Thomas R, Cohen S, Villarreal F. PMID: 19365278; PMCID: PMC2835692.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    88. Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K. Am J Physiol Cell Physiol. 2009 May; 296(5):C1178-84. Villarreal F, Epperson SA, Ramirez-Sanchez I, Yamazaki KG, Brunton LL. PMID: 19279233; PMCID: PMC2681376.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    89. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2009 May; 296(5):C1171-7. Epperson SA, Brunton LL, Ramirez-Sanchez I, Villarreal F. PMID: 19244482; PMCID: PMC2681375.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    90. Cardiac uptake of minocycline and mechanisms for in vivo cardioprotection. J Am Coll Cardiol. 2008 Sep 23; 52(13):1086-94. Romero-Perez D, Fricovsky E, Yamasaki KG, Griffin M, Barraza-Hidalgo M, Dillmann W, Villarreal F. PMID: 18848143; PMCID: PMC2572824.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    91. Short- and long-term effects of (-)-epicatechin on myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H761-7. Yamazaki KG, Romero-Perez D, Barraza-Hidalgo M, Cruz M, Rivas M, Cortez-Gomez B, Ceballos G, Villarreal F. PMID: 18567705; PMCID: PMC2519218.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    92. Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H610-8. Ashikaga H, Coppola BA, Yamazaki KG, Villarreal FJ, Omens JH, Covell JW. PMID: 18515651; PMCID: PMC2519196.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    93. Zinc-binding groups modulate selective inhibition of MMPs. ChemMedChem. 2008 May; 3(5):812-20. Agrawal A, Romero-Perez D, Jacobsen JA, Villarreal FJ, Cohen SM. PMID: 18181119; PMCID: PMC2836234.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    94. Fluorescent method for detection of cleaved collagens using O-phthaldialdehyde (OPA). J Biochem Biophys Methods. 2008 Apr 24; 70(6):878-82. Go K, Horikawa Y, Garcia R, Villarreal FJ. PMID: 17573117; PMCID: PMC2836792.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    95. Effects of timed administration of doxycycline or methylprednisolone on post-myocardial infarction inflammation and left ventricular remodeling in the rat heart. Mol Cell Biochem. 2007 Jun; 300(1-2):159-69. Garcia RA, Go KV, Villarreal FJ. PMID: 17149544.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    96. The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J Am Coll Cardiol. 2006 Feb 21; 47(4):693-700. Asbun J, Villarreal FJ. PMID: 16487830.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    97. Heterocyclic zinc-binding groups for use in next-generation matrix metalloproteinase inhibitors: potency, toxicity, and reactivity. J Biol Inorg Chem. 2006 Mar; 11(2):131-8. Puerta DT, Griffin MO, Lewis JA, Romero-Perez D, Garcia R, Villarreal FJ, Cohen SM. PMID: 16391944.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    98. Differential MMP-2 activity of ligament cells under mechanical stretch injury: an in vitro study on human ACL and MCL fibroblasts. J Orthop Res. 2005 Jul; 23(4):949-57. Zhou D, Lee HS, Villarreal F, Teng A, Lu E, Reynolds S, Qin C, Smith J, Sung KL. PMID: 16023011.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    99. Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibition. Mol Cell Biochem. 2005 Feb; 270(1-2):1-11. Griffin MO, Jinno M, Miles LA, Villarreal FJ. PMID: 15792348.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    100. Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol Pharmacol. 2005 Apr; 67(4):1128-36. García RA, Pantazatos DP, Gessner CR, Go KV, Woods VL, Villarreal FJ. PMID: 15665254.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    101. Abnormal cardiac wall motion and early matrix metalloproteinase activity. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1080-7. García RA, Brown KL, Pavelec RS, Go KV, Covell JW, Villarreal FJ. PMID: 15486029.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    102. Peroxisome proliferator-activated receptors ligands, oxidative stress, and cardiac fibroblast extracellular matrix turnover. Hypertension. 2004 Nov; 44(5):621-2. Villarreal FJ, Asbun J. PMID: 15381678.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    103. Profibrotic influence of high glucose concentration on cardiac fibroblast functions: effects of losartan and vitamin E. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H227-34. Asbun J, Manso AM, Villarreal FJ. PMID: 15345478.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    104. Functional effects of enhancing or silencing adenosine A2b receptors in cardiac fibroblasts. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2478-86. Chen Y, Epperson S, Makhsudova L, Ito B, Suarez J, Dillmann W, Villarreal F. PMID: 15284071.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    105. Early degradation and serum appearance of type I collagen fragments after myocardial infarction. J Mol Cell Cardiol. 2004 Apr; 36(4):597-601. Villarreal F, Omens J, Dillmann W, Risteli J, Nguyen J, Covell J. PMID: 15081319.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    106. Hydrogen/deuterium exchange mass spectrometry for investigating protein-ligand interactions. Assay Drug Dev Technol. 2004 Feb; 2(1):81-91. Garcia RA, Pantazatos D, Villarreal FJ. PMID: 15090213.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    107. Early short-term treatment with doxycycline modulates postinfarction left ventricular remodeling. Circulation. 2003 Sep 23; 108(12):1487-92. Villarreal FJ, Griffin M, Omens J, Dillmann W, Nguyen J, Covell J. PMID: 12952845.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    108. Modulation of cardiac remodeling by adenosine: in vitro and in vivo effects. Mol Cell Biochem. 2003 Sep; 251(1-2):17-26. Villarreal F, Zimmermann S, Makhsudova L, Montag AC, Erion MD, Bullough DA, Ito BR. PMID: 14575299.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
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